CREB

Summary

Gene Symbol: CREB
Description: cAMP responsive element binding protein 1
Alias: CREB, CREB-1, cyclic AMP-responsive element-binding protein 1, active transcription factor CREB, cAMP-response element-binding protein-1, cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, transactivator protein
Species: human

Top Publications

  1. doi Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1, NF-Y, NF-κB, and CREB
    Binu K Sasi
    Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India
    J Mol Biol 426:116-35. 2014
  2. doi PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia
    Kankan Wang
    Sino French Research Center for Life Sciences and Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Cancer Cell 17:186-97. 2010
  3. doi Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
  4. ncbi KIX-mediated assembly of the CBP-CREB-HTLV-1 tax coactivator-activator complex
    Andrew C Vendel
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    Biochemistry 42:12481-7. 2003
  5. pmc Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene
    Sarmila Majumder
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 279:14803-11. 2004
  6. doi FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels
    Elitsa Y Dimova
    Department of Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 13:413-24. 2010
  7. pmc HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)
    Zainulabedin M Saiyed
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Neurochem Int 58:656-64. 2011
  8. doi Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca²⁺ oscillation in central nervous system pericytes
    Kuniyuki Nakamura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 32:2670-7. 2012
  9. doi CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1
    V Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Oncogene 29:4341-51. 2010
  10. ncbi Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003

Research Grants

  1. Molecular Endocrinology of Gene Regulation By cAMP
    Sarah Bronson; Fiscal Year: 2005
  2. Tae Wan Kim; Fiscal Year: 2015
  3. RANDAL SCOT TIBBETTS; Fiscal Year: 2016
  4. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
  5. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
  6. Coleen M Atkins; Fiscal Year: 2016
  7. CREB and Memory Allocation in the Basolateral Amygdala
    THOMAS W ROGERSON; Fiscal Year: 2012
  8. THOMAS ARTHUR GREEN; Fiscal Year: 2015
  9. RAJESH K ANEJA; Fiscal Year: 2016
  10. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013

Detail Information

Publications304 found, 100 shown here

  1. doi Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1, NF-Y, NF-κB, and CREB
    Binu K Sasi
    Cardiovascular Genetics Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India
    J Mol Biol 426:116-35. 2014
    ..NF-Y (nuclear transcription factor Y) at -73/-58 bp, NF-κB (nuclear factor kappa B) at -133/-124 bp, and CREB (cAMP response element binding protein) at -483/-476 bp...
  2. doi PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia
    Kankan Wang
    Sino French Research Center for Life Sciences and Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Cancer Cell 17:186-97. 2010
    ..Thus, selective targeting of PU.1-regulated genes by PML/RARalpha is a critical mechanism for the pathogenesis of APL...
  3. doi Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
    ..In these contexts, AEG-1 represents a viable potential target for the therapy of malignant glioma...
  4. ncbi KIX-mediated assembly of the CBP-CREB-HTLV-1 tax coactivator-activator complex
    Andrew C Vendel
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    Biochemistry 42:12481-7. 2003
    The HTLV-1 transcriptional activator Tax is required for viral replication and pathogenesis. In concert with human CREB, Tax recruits the human transcriptional coactivator and histone acetyltransferase p300/CBP to the HTLV-1 promoter...
  5. pmc Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene
    Sarmila Majumder
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 279:14803-11. 2004
    ..a novel cAMP-response element, CRE-II, in the SMN promoter that interacts with the cAMP-response element-binding (CREB) family of proteins...
  6. doi FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels
    Elitsa Y Dimova
    Department of Biochemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 13:413-24. 2010
    ..reporter gene assays revealed that the peroxide and FOXO4-dependent induction was mediated through the HIF-1 and CREB-binding HRE within the PAI-1 promoter...
  7. pmc HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)
    Zainulabedin M Saiyed
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
    Neurochem Int 58:656-64. 2011
    ..Further, HDAC2 overexpression was associated with concomitant downregulation in CREB and CaMKIIa genes that are known to regulate neuronal activity...
  8. doi Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca²⁺ oscillation in central nervous system pericytes
    Kuniyuki Nakamura
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 32:2670-7. 2012
    ..The aims of the present study were to elucidate how NHE1-induced Ca(2+) signaling during acidosis is transformed into cellular responses in CNS pericytes...
  9. doi CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1
    V Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Oncogene 29:4341-51. 2010
    ..Therefore, the repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation...
  10. ncbi Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003
    ..The cAMP-responsive element-binding protein (CREB) was phosphorylated via these pathways in response to OxPAPC treatment and expression of a dominant-negative mutant ..
  11. doi cAMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells
    Mehdi Banan
    Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Clin Exp Pharmacol Physiol 39:510-7. 2012
    ..Similarities between the HU and sodium butyrate (SB) pathways suggest cAMP response element-binding protein (CREB) 1 as a potential candidate...
  12. pmc Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation
    Gianluca Aguiari
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara, 74, 44121 Ferrara, Italy
    J Mol Med (Berl) 90:1267-82. 2012
    ..We now show by microarray analysis, luciferase assay, mutagenesis, and chromatin immunoprecipitation that CREB and AP1 contribute to increased expression of the amphiregulin gene, which codifies for an epidermal growth factor-..
  13. doi Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages
    Ji Hye Yang
    Department of Microbiology, School of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University Seoul, Republic of Korea
    Exp Neurol 236:199-206. 2012
    ..Moreover, NE abolished Aβ1-42-mediated decline of CREB phosphorylation...
  14. pmc Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts
    Kelly A Brant
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Am J Respir Cell Mol Biol 49:105-13. 2013
    ..Moreover, in the presence of HIF1A, cAMP-mediated signaling pathways may be altered to exacerbate inflammatory-like processes in lung tissue, imparting a susceptibility of PM-exposed populations to adverse respiratory health effects. ..
  15. pmc Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy
    Anthony T Trinh
    Department of Human Oncology, Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Biol Chem 288:23765-75. 2013
    The cyclic AMP response element-binding protein (CREB) initiates transcriptional responses to a wide variety of stimuli...
  16. pmc Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH
    Dipanjan Chanda
    National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea
    PLoS ONE 8:e68845. 2013
    ....
  17. pmc NF-κB and CREB are required for angiotensin II type 1 receptor upregulation in neurons
    Karla K V Haack
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 8:e78695. 2013
    ..The cAMP response element binding protein (CREB) is another transcription factor that has also been implicated in AT1R gene transcription...
  18. doi Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1
    Shervin Hadizadeh
    School of Biology, Parker H Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, GA 30332 0230, United States
    Mol Cell Endocrinol 283:104-13. 2008
    ..Both S1P and PGE2 stimulate the recruitment of LRH-1, cAMP response element binding protein (CREB), CCAAT/enhancer binding proteins (C/EBP), and RNA Polymerase II (Pol II) to the LRH-1 promoter, as well as ..
  19. ncbi Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein
    A Shimomura
    Department of Anatomy, Nagoya University School of Medicine, Japan
    J Biol Chem 271:17957-60. 1996
    Activating transcription factor 1 (ATF1) and the cAMP response element-binding protein (CREB) are members of the CREB/ATF family implicated in cAMP- and calcium-induced transcriptional activation...
  20. doi Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells
    Wenchi Che
    Respiratory Research Group, University of Sydney, NSW, Australia
    Biochim Biophys Acta 1823:1658-65. 2012
    ..MKP-1 is a cAMP response element binding (CREB) protein-responsive gene and here, we reveal for the first time that an adenylate cyclase/PKA/CREB-mediated pathway ..
  21. doi Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells
    Kalpana Velmurugan
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado 80045, USA
    J Neurochem 123:919-31. 2012
    ..Diabetes is a risk factor in the pathogenesis of Alzheimer's disease. Our findings suggest that GLP-1-based therapies can decrease the incidence of Alzheimer's disease among aging diabetic population...
  22. pmc Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
    Ruma Mukerjee
    Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:34976-85. 2011
    ..Interestingly, Vpr deregulates the levels of several microRNAs (e.g. miR-34a) and their target genes (e.g. CREB), which could lead to neuronal dysfunctions...
  23. pmc HIV-1 Tat triggers nuclear localization of ZO-1 via Rho signaling and cAMP response element-binding protein activation
    Yu Zhong
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurosci 32:143-50. 2012
    ..signaling and induced phosphorylation and activity of transcription factor cAMP response element-binding protein (CREB), binding sites that have been identified in the proximal region of the ZO-1 promoter...
  24. pmc The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling
    Yeon Ho Choi
    The Airway Mucus Institute, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 286:34199-214. 2011
    ..Proximity ligation assays showed direct interaction between RSK1 and cAMP response element-binding protein (CREB)...
  25. ncbi The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A
    R P Rehfuss
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 266:18431-4. 1991
    ..Of these CRE-binding proteins, only CREB has been shown to be activated by cAMP-dependent protein kinase A (PKA), and as such, CREB represents the only ..
  26. ncbi Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1
    Anja Krones-Herzig
    Department of Molecular Metabolic Control, German Cancer Research Center Heidelberg, Heidelberg 69120, Germany
    J Biol Chem 281:3025-9. 2006
    ..In hepatocytes, endogenous CARM1 physically interacts with cAMP-responsive element binding factor CREB and is recruited to the PEPCK and glucose-6-phosphatase promoters in a cAMP-dependent manner associated with ..
  27. ncbi IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors
    Katrina Gee
    Department of Pathology and Laboratory Medicine, Division of Virology and Molecular Immunology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    J Immunol 178:798-807. 2007
    ..Furthermore, Tat-induced IL-10 expression was regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors...
  28. pmc HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
    J Robert Chang
    Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:41125-34. 2011
    ..Tat also decreases the levels of miR-34a target genes such as CREB protein as shown by real time PCR. The effect of Tat was neutralized in the presence of anti-miR-34a...
  29. doi MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas
    Lin Chen
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China
    IUBMB Life 64:628-35. 2012
    ..These results indicate that miR-181b may function as a tumor suppressor in gastric adenocarcinoma cells through negative regulation of CREB1...
  30. pmc Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism
    Séverine Boulon
    Institut de Genetique Moleculaire, CNRS, UMR 5535, IFR24, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 22:7769-79. 2002
    ..located upstream of the cyclin D1 mRNA start site, integrates mitogenic signals that target the CRE-binding factor CREB, which can recruit the transcriptional coactivator CREB-binding protein (CBP)...
  31. ncbi Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription
    Nienke van der Stoep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    J Immunol 169:5061-71. 2002
    ..We show that activating transcription factor (ATF)/CRE binding protein (CREB) factors bind to the CREs in vitro and in vivo...
  32. ncbi PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation
    Dominique Sawka-Verhelle
    Departments of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 279:17772-84. 2004
    ..evidence that the PE-1/METS gene is a transcriptional target of the cyclic AMP response element-binding protein-1 (CREB-1)...
  33. ncbi Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene
    Lilah Rothem
    Department of Biology, The Technion Israel Institute of Technology, Haifa, 32000, Israel
    Mol Pharmacol 66:1536-43. 2004
    ..Consistent with the autoregulation of CREB-1 gene expression by pCREB-1, prominently decreased CREB-1 mRNA levels were observed in antifolate-resistant cells...
  34. pmc Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 modulate beta-cell chromatin structure
    Su Jin Kim
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 284:12896-904. 2009
    ..its association with the transcription factor, phosphorylated cAMP-response element-binding protein (phospho-CREB) and with cAMP-responsive CREB coactivator 2...
  35. pmc cAMP stringently regulates human cathelicidin antimicrobial peptide expression in the mucosal epithelial cells by activating cAMP-response element-binding protein, AP-1, and inducible cAMP early repressor
    Krishnendu Chakraborty
    Department of Clinical Medicine, National Institute of Cholera and Enteric Diseases, P 33 C I T Road, Scheme XM, Beliaghata, Kolkata 700010, India
    J Biol Chem 284:21810-27. 2009
    ..cAMP-response element-binding protein (CREB) and AP-1 (activator protein-1) bind to the cathelicidin putative promoter in vitro...
  36. pmc The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription
    Y M Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    Oncogene 29:2142-52. 2010
    ..Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter ..
  37. ncbi Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway
    Hwa Young Lee
    Department of Gastroenterology, College of Medicine, Kangnam CHA Hospital, CHA University, Seoul, 650 9, Korea
    Int J Oncol 36:941-53. 2010
    ..that DCA upregulates MUC2 transcription via multiple pathways involving activation of EGFR/PKC/Ras/Raf-1/MEK1/ERK/CREB, PI3/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB while DCA induced MUC2 transcription is inhibited by JNK/c-Jun/AP-1 ..
  38. ncbi Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells
    J Leonard
    Clayton Foundation Laboratories for Peptide Biology, La Jolla, California 92037
    Mol Endocrinol 7:1275-83. 1993
    ....
  39. ncbi Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells
    D Gibellini
    Institute of Microbiology, University of Bologna, Italy
    J Immunol 160:3891-8. 1998
    ..ng/ml) induced a rapid (peak at 30 min) increase in the Ser133 phosphorylation levels of the transcription factor CREB in serum-starved Jurkat cells, as revealed by Western blot and indirect immunofluorescence analyses...
  40. ncbi Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e
    Eun Kyoung Joo
    Department of Biochemistry, Biotechnology Research Institute, Chungbuk National University, Cheongju, Chungbuk, 361 763, Korea
    Stem Cells Dev 13:563-70. 2004
    ..were directly linked to enhanced phosphorylation of p70/85S6K and cAMP responsive element binding protein (CREB), as well as enhanced induction of the Bcl-2 family member Mcl-1...
  41. ncbi Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements
    Pavan Adiseshaiah
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Oncogene 24:4193-205. 2005
    ..Using ChIP assays we show that, in contrast to c-Jun, SRF, Elk1, ATF1 and CREB proteins bind to SRE and ATF sites of the FRA-1 promoter, constitutively...
  42. ncbi Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells
    Katrina Gee
    Department of Pathology, Division of Virology, Research Institute, Children s Hospital of Eastern Ontario, Ottawa K1H 8L1, Canada
    J Biol Chem 281:31647-58. 2006
    ..Furthermore, intracellular Tat activated the CREB-1 transcription factor through Ser(133) phosphorylation that was regulated by ERK MAPK as determined by IL-10 ..
  43. ncbi Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB
    Thorsten Cramer
    Laboratory for Angiogenesis and Tumor Metastasis, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Cell Signal 20:60-72. 2008
    ..Our previous work revealed that gastrin regulates chromogranin A (CgA) transcription through enhanced binding of Sp1, CREB and Egr-1 to a proximal gastrin-responsive promoter element (Gas-RE)...
  44. pmc Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    PLoS ONE 4:e5130. 2009
    ..The question is important because of the clinical significance of fascin expression in human carcinomas...
  45. pmc Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
    Enjing Jin
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 114:5557-66. 2009
    ..sites for E74-like factor 1 (ELF-1; between -49 and -52), cyclic adenosine monophosphate response element binding (CREB; between -74 and -81), and early growth response factor 1/3 (EGR-1/3; between -16 to -25) were shown to play a ..
  46. pmc Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB
    Q Zhou
    Department of Microbiology and Cancer Center, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Virol 69:4323-30. 1995
    ..that the mechanism of transcriptional repression by YY1 might involve a direct interaction with members of the ATF/CREB family of transcription factors...
  47. ncbi Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
    J Arias
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037
    Nature 370:226-9. 1994
    ..of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB at Ser 133...
  48. ncbi Phosphorylated CREB binds specifically to the nuclear protein CBP
    J C Chrivia
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 365:855-9. 1993
    ..Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A...
  49. ncbi Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
    J Xing
    Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA
    Science 273:959-63. 1996
    ..growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription...
  50. pmc FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
    Y Tan
    Cell Signaling Laboratory, New England Biolabs, Beverly, MA 01915, USA
    EMBO J 15:4629-42. 1996
    ..regulates gene expression at a cyclic-AMP response element (CRE) by stimulating the transcriptional activity of CREB. The activation of CREB is prevented by a dominant negative mutant of Ras and triggered via the same site (Ser133) ..
  51. ncbi Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions
    I Radhakrishnan
    Department of Molecular Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 91:741-52. 1997
    The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  52. pmc Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    M Deak
    MRC Protein Phosphorylation Unit, Departments of Biochemistry, Anatomy and Physiology, University of Dundee, Scotland
    EMBO J 17:4426-41. 1998
    ..MSK1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates CREB at Ser133 with a Km value far lower than PKA, MAPKAP-K1(p90Rsk) and MAPKAP-K2...
  53. ncbi Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression
    N Ban
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Diabetes 49:1142-8. 2000
    ..islets, ATF-2 enhanced glucose-induced insulin promoter activity, whereas cAMP response element-binding protein (CREB) repressed it...
  54. pmc MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
    Giselle R Wiggin
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Mol Cell Biol 22:2871-81. 2002
    ..we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts...
  55. pmc Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia
    Katrina M Comerford
    The Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, D4 Ireland
    Proc Natl Acad Sci U S A 100:986-91. 2003
    ..previously shown to involve phosphorylation-dependent degradation of the cAMP-response element-binding protein (CREB)...
  56. ncbi Sequence variations in CREB1 cosegregate with depressive disorders in women
    G S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 8:611-8. 2003
    ..These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions...
  57. pmc Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
    Vadim Iourgenko
    Department of Functional Genomics, Novartis Institute for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:12147-52. 2003
    ..A protein, termed transducer of regulated cAMP response element-binding protein (CREB) (TORC1), was identified that activated expression through the variant CRE and consensus CRE sites...
  58. pmc Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress
    Yuling Shi
    Molecular and Cellular Pharmacology Program, Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:5898-903. 2004
    ..we describe a signal transduction pathway linking ATM directly to the Ca(2+)/cAMP response element-binding protein, CREB, a transcription factor that regulates cell growth, homeostasis, and survival...
  59. pmc CREB binds to multiple loci on human chromosome 22
    Ghia Euskirchen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8005, USA gt
    Mol Cell Biol 24:3804-14. 2004
    The cyclic AMP-responsive element-binding protein (CREB) is an important transcription factor that can be activated by hormonal stimulation and regulates neuronal function and development...
  60. ncbi The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
    Robert A Screaton
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 119:61-74. 2004
    ..pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe a signaling module that mediates the synergistic effects of these pathways on cellular gene ..
  61. pmc Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
    Xinmin Zhang
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:4459-64. 2005
    ..cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at Ser-133...
  62. ncbi The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia
    Deepa B Shankar
    Division of Hematology Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories and Mattel Children s Hospital, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Cancer Cell 7:351-62. 2005
    b>CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer...
  63. ncbi Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen
    Buka Samten
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708, USA
    J Immunol 174:6357-63. 2005
    ..b>CREB binds to the IFN-gamma proximal promoter, and binding is enhanced by phosphorylation of CREB...
  64. pmc Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival
    Junghee Lee
    Neurology Department, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:40398-401. 2005
    Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established...
  65. ncbi Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis
    Vladislava O Melnikova
    Department of Cancer Biology, the University of Texas M D Anderson Cancer Center and the Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    J Biol Chem 281:2911-22. 2006
    Overexpression of cAMP-response element (CRE)-binding protein (CREB) and activating transcription factor (ATF) 1 contributes to melanoma progression and metastasis at least in part by promoting tumor cell survival and stimulating matrix ..
  66. ncbi Antiapoptotic effect of human T-cell leukemia virus type 1 tax protein correlates with its creb transcriptional activity
    Roberta Trevisan
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Italy
    Exp Cell Res 312:1390-400. 2006
    ..the action of Tax, in the present study, we investigated the outcome of Tax and two mutants which are inactive in CREB/ATF (M47) or NF-kappaB (M22) pathways, in the control of apoptosis induced by the proapoptotic Bax protein...
  67. pmc Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach
    Cynthia de La Fuente
    The George Washington University Medical Center, Department of Biochemistry and Molecular Biology, Washington, DC 20037, USA
    Retrovirology 3:43. 2006
    ..Tax transactivates these cellular promoters by interacting with transcription factors such as CREB/ATF, NF-kappaB, and SRF...
  68. pmc Regulation of the human SOX9 promoter by Sp1 and CREB
    Sonsoles Piera-Velazquez
    Department of Medicine, Division of Rheumatology, Thomas Jefferson University, Jefferson Medical College, 233 S 10th Street, Room 509 BLSB, Philadelphia, PA 19107 5541, USA
    Exp Cell Res 313:1069-79. 2007
    ..report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1...
  69. ncbi Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation
    Young Mi Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    J Biol Chem 282:18750-7. 2007
    ..elements (CREs), which are recognized by the cellular transcription factor cAMP-response element-binding protein (CREB). Tax binds to GC-rich sequences that immediately flank the CREs...
  70. pmc Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
    Kim Ravnskjaer
    Peptide Biology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 26:2880-9. 2007
    A number of hormones and growth factors stimulate gene expression by promoting the phosphorylation of CREB (P-CREB), thereby enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300)...
  71. pmc Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300
    Julita A Ramírez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Mol Biol 372:958-69. 2007
    ..Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter...
  72. pmc Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
    ..These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
  73. pmc The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB
    Timothy R Geiger
    Department of Biochemistry and Molecular Biology, Campus Box 1870, Colorado State University, Fort Collins, CO 80523 1870, USA
    Mol Cell Biol 28:1383-92. 2008
    ..Tax function is strictly dependent upon the cellular transcription factor CREB, and together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription...
  74. pmc Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway
    Di Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:16299-308. 2008
    ..By using Tax, cAMP-responsive element-binding protein (CREB)-1, CREB-2, and their mutants, we further showed that Tax repressed ZNF268 through the CREB/activating ..
  75. pmc Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer
    Hye Sook Seo
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 USA
    Cancer Res 68:6065-73. 2008
    ..Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of growth of several types of cancers and our recent findings of its importance in ..
  76. pmc RGS13 acts as a nuclear repressor of CREB
    Zhihui Xie
    Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 31:660-70. 2008
    Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions...
  77. pmc Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis
    Hongxia Sun
    Department of Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:316-28. 2008
    ..overexpression in NSCLC cells was abrogated with the knockdown of cyclic AMP-responsive element binding protein (CREB) or nuclear factor kappaB (NF-kappaB)...
  78. pmc CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy
    Kathleen M Sakamoto
    Division of Hematology Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children s Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Clin Cancer Res 15:2583-7. 2009
    ..One such transcription factor is the cAMP-regulatory element-binding protein (CREB), which can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, ..
  79. pmc Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma
    Andrey S Dobroff
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:26194-206. 2009
    ..progression of melanoma is associated with overexpression and activity of cAMP-response element-binding protein (CREB). However, the mechanism by which CREB contributes to tumor progression and metastasis remains unclear...
  80. doi Cooperation of NFkappaB and CREB to induce synergistic IL-6 expression in astrocytes
    Anneleen Spooren
    Department of Physiology, Ghent University, Belgium
    Cell Signal 22:871-81. 2010
    ..Simultaneous induction with isoproterenol and TNF-alpha was moreover associated with combined recruitment of CREB and p65 to the native IL-6 promoter...
  81. pmc ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB
    Yuqing Zhang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Molecular Surgeon Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 16:1423-30. 2010
    ..We have recently found that ZIP4 is overexpressed in pancreatic cancer. In this study, we investigated the signaling pathway through which ZIP4 regulates pancreatic cancer growth...
  82. doi cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction
    Jieun Son
    Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
    Biochem Biophys Res Commun 398:309-14. 2010
    cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer...
  83. pmc A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation
    Pietro Laneve
    Institute of Molecular Biology and Pathology National Research Council CNR and Institute Pasteur Cenci Bolognetti, Department of Genetics and Molecular Biology, Sapienza University, P le Aldo Moro 5 00185 Rome, Italy
    Nucleic Acids Res 38:6895-905. 2010
    ..master transcriptional factors RE1-silencing transcription factor (REST) and cAMP-response element binding protein (CREB) on miR-9-2 promoter induces miRNA expression during differentiation...
  84. pmc The role of the transcription factor CREB in immune function
    Andy Y Wen
    Division of Pediatric Critical Care, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 185:6413-9. 2010
    b>CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation...
  85. doi Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells
    Chen Yang
    Center for Molecular Medicine, The First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, 76 West Yanta Road, 710061 Xi an, China
    Gene 496:8-16. 2012
    ..in western blot analysis, p300 (encoded by EP300) and its coactivator cAMP response element-binding protein (CREB) level were significantly down-regulated...
  86. doi MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma
    Wei Qing Kong
    Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China
    FEBS J 279:1252-60. 2012
    ..These results indicate that miR-182 targets the CREB1 gene and suppresses gastric adenocarcinoma cell growth, suggesting that miR-182 shows tumor-suppressive activity in human gastric cancer...
  87. pmc cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a
    Xiaochao Tan
    State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Proc Natl Acad Sci U S A 109:15805-10. 2012
    ..In this study, we showed that cAMP response element-binding protein (CREB), a proto-oncogenic transcription factor that is overexpressed in gliomas, can promote gliomagenesis by modulating ..
  88. pmc Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein
    S Dan
    Department of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108, Japan
    J Virol 73:3258-63. 1999
    ..In the trans activation of multiple copies of 21-bp sequence, CREB/ATF protein plays an essential role in forming a complex with Tax...
  89. ncbi Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation
    F Liu
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    J Biol Chem 268:6714-20. 1993
    ..This element is the binding site for activating transcription factor (ATF)/CREB proteins, an extensive transcription factor family...
  90. ncbi Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB
    Jordi Rius
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 24:697-702. 2004
    ..Our aim was to analyze whether NOR-1 is involved in LDL-induced mitogenic effects in VSMC...
  91. pmc Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains
    J Kim
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Nucleic Acids Res 23:2531-7. 1995
    The AP-1 and ATF/CREB families of eukaryotic transcription factors are dimeric DNA-binding proteins that contain the bZIP structural motif...
  92. pmc Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes
    L Folgueira
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 70:223-31. 1996
    ..is concluded from the inability of PKC-zeta(mut) to interfere with the basal or phorbol myristate acetate-inducible CREB- or AP1-dependent transcriptional activity...
  93. ncbi Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3
    S Takahata
    Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan
    Genes Cells 5:739-47. 2000
    ..Yeast and mammalian two-hybrid systems revealed that CBP and p300 interacted with mArnt3 via the CREB binding domain. The In vivo interaction between mArnt3 and CBP was confirmed by the GST pull down assay...
  94. doi The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo
    X L Jin
    Human Reproduction Unit, Sydney Centre for Developmental and Regenerative Medicine, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
    Biol Reprod 82:459-68. 2010
    ..The expression of two members of an important family of transcription factors, cAMP response element-binding protein (CREB) and cAMP-dependent transcription factor ATF1 (ATF1), is essential for normal preimplantation development...
  95. ncbi Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts
    K Yagita
    Department of Anatomy and Brain Science, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan
    FEBS Lett 465:79-82. 2000
    ..initial step of the circadian gene expression, a marked transient induction of Per1 was observed accompanied with CREB phosphorylation...
  96. ncbi Persistent ERK phosphorylation negatively regulates cAMP response element-binding protein (CREB) activity via recruitment of CREB-binding protein to pp90RSK
    Ziqiu Wang
    Liver Cancer Center, Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:11138-44. 2003
    ..might induce cell growth inhibition, we used Cpd 5 as a tool to examine its effects on the activity of CREB (cAMP response element-binding protein) transcription factor in Hep3B human hepatoma cells...
  97. pmc Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, USA
    Environ Health Perspect 118:400-6. 2010
    ..Bisphenol A (BPA), a chemical used as a plasticizer, is a potent endocrine disruptor that, even in low concentrations, disturbs normal development and functions of reproductive organs in different species...
  98. pmc Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart
    Nazira Ozgen
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 283:17009-19. 2008
    Many growth regulatory stimuli promote cAMP response element-binding protein (CREB) Ser(133) phosphorylation, but the physiologically relevant CREB-Ser(133) kinase(s) in the heart remains uncertain...
  99. ncbi Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2
    Keith E Fox
    Research Service, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 281:40341-53. 2006
    ..In addition, activation of the cAMP-response element-binding protein (CREB) is necessary and sufficient to promote adipogenic conversion and prevent apoptosis of mature adipocytes...
  100. ncbi [Effects of predator stress on the expression of cAMP responsive element binding protein in hippocampus: experiment with rats]
    Qing Song Wang
    Department of Neurology, Chengdu Army General Hospital, Chengdu 610083, China
    Zhonghua Yi Xue Za Zhi 87:3367-71. 2007
    ..To explore the neurobiological basis involved in the pathogenesis of the lasting emotionality and cognitive impairment following severe psychological stress...
  101. ncbi Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
    Emmanual Unni
    Department of Medicine, Baylor College of Medicine and VA Medical Center, Houston, Texas, USA
    Cancer Res 64:7156-68. 2004
    ..protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-1/2-ERK-1/2-cAMP-response element binding-protein (CREB)...

Research Grants66

  1. Molecular Endocrinology of Gene Regulation By cAMP
    Sarah Bronson; Fiscal Year: 2005
    ..of the research described here is to understand the mechanisms used by the cAMP response element binding protein, CREB, to regulate gene transcription in the basal state and in response to signals generate by stimulation of cells with ..
  2. Tae Wan Kim; Fiscal Year: 2015
    ..results showed that A[unreadable]-induced suppression of phosphorylation of cAMP response element-binding protein (CREB), a critical transcription factor associated with synaptic plasticity and memory, was absent in primary neurons ..
  3. RANDAL SCOT TIBBETTS; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The overarching goal of this study is to define novel roles for CREB/ATF transcription factors in genome protection...
  4. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ..Depolarizing stimuli that open LTCCs activate the transcription factors cAMP-response element binding protein (CREB) and nuclear factor of activated T-cells (NFAT) through Ca2+-regulated kinase and phosphatases...
  5. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..acts along with other kinases to activate transcription factors such as cAMP response element binding protein (CREB), leading to gene induction and long-term memory storage...
  6. Coleen M Atkins; Fiscal Year: 2016
    ..kinase (ERK) and one of its downstream effectors, the transcription factor cAMP-response element binding protein (CREB), is significantly impaired in the hippocampus from 2 weeks to 3 months after TBI...
  7. CREB and Memory Allocation in the Basolateral Amygdala
    THOMAS W ROGERSON; Fiscal Year: 2012
    ..Results from our laboratory have suggested that the transcription factor CREB (cAMP-response element binding protein) has a role in memory allocation in the basolateral amygdala (BLA);..
  8. THOMAS ARTHUR GREEN; Fiscal Year: 2015
    ..due, at least in part, to decreases in activity of the transcription factor cAMP response-element binding protein (CREB), with the net effect of decreasing neuronal excitability of nucleus accumbens (NAc) medium spiny neurons...
  9. RAJESH K ANEJA; Fiscal Year: 2016
    ..acetyl-transferase (HAT) activity of p300 and a closely related protein, cAMP response element-binding protein (CREB)-binding protein (CBP);3) PARP-1 inhibits LPS-mediated HMGB1 gene transcription...
  10. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..signal activates protein kinase A (PKA), which phosphorylates the nuclear cAMP response element binding protein (CREB)...
  11. Fanyin Meng; Fiscal Year: 2016
    ..and/or inhibition of nuclear factor of activated T cells (NFAT) and cAMP- response-element-binding protein (CREB) signaling, respectively...
  12. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Additional data suggest a role for cAMP response element-binding protein (CREB) in activation of C/EBP expression...
  13. Transcriptional Regulation of PDGF Receptor Alpha
    Jane Reusch; Fiscal Year: 2009
    ..We recently reported that overexpression of the cAMP Response Element Binding Protein (CREB) transcription factor decreases SMC migration and proliferation...
  14. WILLIAM RAMSES BISHAI; Fiscal Year: 2014
    ..signal transduction by induction of protein kinase A (PKA), upregulation of cAMP-response element binding protein (CREB) phosphorylation, and a cascade of additional responses including excess TNF-1 secretion...
  15. Adolescent nicotine exposure and subsequent alcohol use
    Rex M Philpot; Fiscal Year: 2010
    ..cAMP response element binding protein (CREB) and AFosB (a truncated form of FosB) and that these alterations lead to the expression of genes thought to mediate ..
  16. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..During the prior grant period we found that over-expression of CREB (cAMP response element binding protein) dramatically increased fear conditioning...
  17. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..molecules, including calcium/calmodulin- dependent kinase II (CaMKII) and cAMP-response element binding protein (CREB), in response to the traumatic experience and then, weeks later, to a reminder of that experience...
  18. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..Chromatin Immunoprecipitation (ChIP) assays demonstrated that NFkB and cAMP response element binding protein (CREB) was induced by HSV-1 infection and recruited to the Egr-1 promoter upon infection...
  19. Liya Qiao; Fiscal Year: 2016
    ..pathways including Ca2+/calmodulin-dependent protein kinase (CaMK)II, cAMP-response element binding protein (CREB), calcitonin gene-related peptide (CGRP), and cerebellin 1 precursor (Cbln1) in bladder afferent neurons before and ..
  20. Rebecca L Berdeaux; Fiscal Year: 2015
    ..The cAMP response element binding protein CREB and its co-activator CRTC2 regulate hepatic glucose output by transcriptional induction of rate-limiting ..
  21. Xiangshu Xiao; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The goal of the proposed research is to develop small molecule inhibitors of CREB (cAMP-response element binding protein)-mediated gene transcription as potential anticancer agents...
  22. Calcium and Gene Expression in Vascular Smooth Muscle
    Karen M Lounsbury; Fiscal Year: 2010
    ..have shown that different sources of Ca2+ lead to the activation of the Ca2+/cAMP response element binding protein (CREB) resulting in transcription of selective gene targets...
  23. YVONNE MICHELLE ULRICH-LAI; Fiscal Year: 2015
    ..We will test this hypothesis in three specific aims. The first aim will use intra-BLA blockade of CREB/pCREB expression to determine whether this signaling pathway mediates sucrose-induced synaptic reorganization and ..
  24. CELLULAR MECHANISMS OF ASSOCIATIVE LEARNING
    John H Byrne; Fiscal Year: 2012
    ..3) Examine the role of cAMP response element binding protein 1 (CREB1) in long-term changes in the membrane properties of B51. 2...
  25. ELIZABETH GENEVIEVE MIETLICKI-BAASE; Fiscal Year: 2014
    ..Specific Aim I tests the hypothesis that cAMP response element binding protein (CREB), an intracellular mediator of gene expression, is required for the sustained energy balance effects of GLP-1 ..
  26. Alisha D Howard; Fiscal Year: 2014
    ..Tax recruits the cellular proteins cAMP-response element binding protein (CREB) and p300/CREB-binding protein (CBP) to viral CRE sites located in the HTLV-1 LTR (for review see [1])...
  27. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN TED G ABEL; Fiscal Year: 2010
    ..expression by PKA and other kinases via transcription factors such as the cAMP response element binding protein (CREB)...
  28. Russell W Brown; Fiscal Year: 2015
    ..nAChR, and the [unreadable]7 nAChR antagonist MLA will reduce nicotine-induced increased of BDNF and p-CREB protein in neonatal quinpirole rats...
  29. The Role of CREB in Normal Myelopoiesis and Leukemogenesis
    KATHLEEN MIHO SAKAMOTO; Fiscal Year: 2013
    ..aims of my previous R01 grant addressed the overall hypothesis that the cAMP Response Element Binding Protein (CREB) contributes to leukemogenesis. In the initial funding period, we described the overexpression of CREB in AML...
  30. Subbiah Pugazhenthi; Fiscal Year: 2016
    ..Cyclic AMP response element binding protein (CREB), a nuclear transcription factor, enhances cognition, memory formation and neuronal survival...
  31. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..to leptin (direct, through phosphorylation of STAT3, and to [unreadable]-MSH (indirect, through phosphorylation CREB) (1), and since resistance to leptin is mostly located at the level of the ARC, we propose that the direct pathway ..
  32. The role of CREB in stress-induced reinstatement
    Lisa A Briand; Fiscal Year: 2012
    ..Recent work in our lab has demonstrated that cAMP response element binding protein (CREB) is necessary for stress- but not cocaine-induced reinstatement of conditioned place preference using mice with a ..
  33. Role of CREB function in the BNST in fear and anxiety-like behaviors
    Edward Meloni; Fiscal Year: 2007
    ..in this proposal is to examine the role of the transcription factor cAMP response element-binding protein (CREB) in the acquisition and expression of fear and anxiety- like behaviors...
  34. Mechanisms underlying opposing neuronal responses to brief vs. prolonged dopamine
    DEBORAH JEAN BARO; Fiscal Year: 2012
    ..changes in [cAMP] that then alter the phosphorylation state of both Kv4 channels and a transcription factor named CREB. Whereas changes in Kv4 channels are relatively short-lived, modifications in CREB activity are long-lived and ..
  35. CREB-Mediated Survival of Deafferented Auditory Neurons
    Lance Zirpel; Fiscal Year: 2005
    ..role of phosphorylation and activation of the transcription factor calcium/cAMP response element binding protein (CREB) in the subpopulation of cochlear nucleus neurons that survive activity deprivation...
  36. CREB TRANSCRIPTION FACTOR IN LPS TREATED MACROPHAGES
    STEVE WEINSTEIN; Fiscal Year: 1999
    ..genes contain cAMP responsive elements (CRE) in their promoters, the cAMP response element binding protein, CREB, is likely to be important in LPS signaling...
  37. NEUROTROPHIN REGULATION OF CRE-BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2000
    ..Neurotrophins activate the transcription factor CREB (cAMP-response element binding protein) by inducing phosphorylation of CREB on a transcriptional regulatory site, ..
  38. Neurotrophin Signaling and Regulation of Gene Expression
    David D Ginty; Fiscal Year: 2010
    ..We have shown that a retrogradely propagated NGF/TrkA signal in sympathetic neurons supports CREB activity, gene expression and neuronal survival...
  39. Synapse to Nuclear Signaling During Long-Lasting Neuronal Plasticity
    Kelsey C Martin; Fiscal Year: 2013
    ..We focus this continuation proposal on the synapse to nuclear transport of the CREB regulated transcriptional coactivator CRTC1 during activity-dependent plasticity...
  40. Mechanisms regulating PKGI proteolysis and modulation of pulmonary SMC phenotype
    Jesse D Roberts; Fiscal Year: 2013
    ..PKGI nuclear localization and phosphorylation of nuclear proteins and transcription factors, such as CREB and ATF-1, regulate SMC phenotype...
  41. Nuclear pathway of DISC1 in major mental illnesses: biochemistry and cell biology
    Akira Sawa; Fiscal Year: 2012
    ..that DISC1 functions as a scaffold at the nuclear body to recruit components of activator/repressor complex to CREB/ATF transcriptional machinery...
  42. John S Davis; Fiscal Year: 2014
    ..determine whether 2-catenin interaction with LRH-1 recruits additional transcriptional co-activators, such as CBP (CREB-binding protein), during the regulation of StAR expression and progesterone synthesis...
  43. Claude A Piantadosi; Fiscal Year: 2016
    ..AMPK may serve as an activator of three crucial transcription factors- CREB, NRF-1, and NRF- 2 (GABPA) for mitochondrial biogenesis in sepsis, but NO regulation also induces mitochondrial ..
  44. Hamid I Akbarali; Fiscal Year: 2014
    ..In this aim we will measure phosphorylation of the transcription factor CREB, and the downstream activation of cyclic AMP response element (CRE)...
  45. Marc R Montminy; Fiscal Year: 2016
    ..pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
  46. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
  47. Makoto Miyazaki; Fiscal Year: 2016
    ..ATF4 is a member of the cAMP-responsive element-binding protein (CREB) family of basic zipper-containing transcription factors that regulates osteogenesis and also mediates unfolded ..
  48. Robert J Cousins; Fiscal Year: 2016
    ..ZIP8 mediated transport of Zn2+ from lysosomes of activated T cells maintains CREB in its phosphorylated forum enabling enhanced IFNy transcription...
  49. Regulation of energy balance in Drosophila
    John B Thomas; Fiscal Year: 2012
    ..The CREB family of transcription factors participates in a variety of cellular functions including energy homeostasis...
  50. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..We detected IFNR2 acetylation by recruiting tumor suppressor-like transcription cofactor CREB-binding protein (CBP) or its homologous p300. Acetylated IFNR2 can then recruit IRF9...
  51. In vivo Analysis of ATM-Regulated Pathways
    RANDAL SCOT TIBBETTS; Fiscal Year: 2011
    ..pathway linking ATM (ataxia-telangiectasia-mutated) to the cyclic AMP response element-binding protein (CREB) transcription factor;and (ii) identify and functionally characterize novel ATM substrates...
  52. Lahouaria Hadri; Fiscal Year: 2014
    ..The protein phosphatase 1 (PP1), the main regulator of the transcription factor CREB, is strongly involved in the control of cell proliferation via p53 and p21...
  53. Jesse Roman; Fiscal Year: 2016
    ..in lung fibroblasts, we observed induction of the MEK-1/Erk pathway and phosphorylation of the transcription factor CREB. In turn, CREB stimulated the expression of fibronectin, a matrix glycoprotein implicated in lung injury and repair...
  54. Activation of the cyclin D1 promoter by arsenite
    MARK L STEINBERG; Fiscal Year: 2012
    ..Electrophoretic mobility shift assays (EMSA) demonstrated enhanced binding of AP1 and CREB transcription factors to their cognate binding motifs in the cyclin D1 promoter Here we wish to continue the work ..
  55. Nongenomic Androgen Signaling in Sertolli Cells
    William H Walker; Fiscal Year: 2010
    ..causes the phosphorylation and activation of the Src and ERK kinases, the epidermal growth factor receptor and the CREB transcription factor...
  56. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..the vCREs through protein-DNA interactions and protein-protein interactions with the cellular transcription factor CREB. Together, this complex recruits the cellular coactivators CBP/p300, which is a fundamental step in transcriptional ..
  57. Wen Wei Tsai; Fiscal Year: 2014
    ..the gluconeogenic program in part via PKA-mediated phosphorylation and activation of the transcription factor CREB. The CREB coactivator, CRTC2, has been shown to function as an essential interacting partner in CREB-induced ..
  58. Yoshiaki Tsuji; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The CREB (cAMP-response element binding) transcription factor is a stimulus-induced phospho-protein that is involved in numerous cell signaling pathways...
  59. Role of dopamine signaling in the mood-related effects of salvinorin A
    Elena H Chartoff; Fiscal Year: 2013
    ..In the NAc, ERK can activate CREB, a transcription factor associated with aversive states (Carlezon et al., 1998;Pliakas et al., 2001)...
  60. Michael Kahn; Fiscal Year: 2016
    ..that differentially modulate interactions between b-catenin and either of its transcriptional coactivators, p300 or CREB binding protein (CBP), have led us to propose a model to explain dichotomous activities of Wnt/[unreadable]-catenin ..
  61. Coregulatory factor modulation of CREB activity
    ROLAND P KWOK; Fiscal Year: 2010
    ..Our preliminary data show that CBP, the co-activator of the CRE-binding protein CREB, forms a complex with co-repressor histone deacetylases (HDAC)...
  62. John H Byrne; Fiscal Year: 2016
    ..The success of these studies will help the development of a new paradigm for cognitive enhancement that can have broad generality, including improving human health. ..
  63. Molecular and Cellular Characterization of Myeloproliferative Disease
    KATHLEEN MIHO SAKAMOTO; Fiscal Year: 2010
    ..Therefore, it is imperative that we identify alternative approaches to treat MPD. We generated CREB transgenic mice in which the cAMP Response Element Binding protein (CREB) is expressed in the myeloid lineage...