CREB

Summary

Gene Symbol: CREB
Description: cAMP responsive element binding protein 1
Alias: CREB, CREB-1, cyclic AMP-responsive element-binding protein 1, active transcription factor CREB, cAMP-response element-binding protein-1, cyclic adenosine 3',5'-monophosphate response element binding protein, cyclic adenosine 3',5'-monophosphate response element-binding protein CREB, transactivator protein
Species: human
Products:     CREB

Top Publications

  1. Kong W, Bai R, Liu T, Cai C, Liu M, Li X, et al. MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. FEBS J. 2012;279:1252-60 pubmed publisher
    ..These results indicate that miR-182 targets the CREB1 gene and suppresses gastric adenocarcinoma cell growth, suggesting that miR-182 shows tumor-suppressive activity in human gastric cancer. ..
  2. Samten B, Howard S, Weis S, Wu S, Shams H, Townsend J, et al. Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen. J Immunol. 2005;174:6357-63 pubmed
    ..b>CREB binds to the IFN-gamma proximal promoter, and binding is enhanced by phosphorylation of CREB...
  3. Zubenko G, Hughes H, Stiffler J, Brechbiel A, Zubenko W, Maher B, et al. Sequence variations in CREB1 cosegregate with depressive disorders in women. Mol Psychiatry. 2003;8:611-8 pubmed
    ..These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions. ..
  4. Tan X, Wang S, Zhu L, Wu C, Yin B, Zhao J, et al. cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a. Proc Natl Acad Sci U S A. 2012;109:15805-10 pubmed
    ..In this study, we showed that cAMP response element-binding protein (CREB), a proto-oncogenic transcription factor that is overexpressed in gliomas, can promote gliomagenesis by modulating ..
  5. Wiggin G, Soloaga A, Foster J, Murray Tait V, Cohen P, Arthur J. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002;22:2871-81 pubmed
    ..we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts...
  6. Wang D, Guo M, Hu H, Zhao Z, Qiu H, Shao H, et al. Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway. J Biol Chem. 2008;283:16299-308 pubmed publisher
    ..By using Tax, cAMP-responsive element-binding protein (CREB)-1, CREB-2, and their mutants, we further showed that Tax repressed ZNF268 through the CREB/activating ..
  7. Wen A, Sakamoto K, Miller L. The role of the transcription factor CREB in immune function. J Immunol. 2010;185:6413-9 pubmed publisher
    b>CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation...
  8. Zhang X, Odom D, Koo S, Conkright M, Canettieri G, Best J, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102:4459-64 pubmed
    ..cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at Ser-133...
  9. Xie Z, Geiger T, Johnson E, Nyborg J, Druey K. RGS13 acts as a nuclear repressor of CREB. Mol Cell. 2008;31:660-70 pubmed publisher
    Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions...

More Information

Publications81

  1. Piera Velazquez S, Hawkins D, Whitecavage M, Colter D, Stokes D, Jimenez S. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007;313:1069-79 pubmed
    ..report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1...
  2. Shankar D, Cheng J, Kinjo K, Federman N, Moore T, Gill A, et al. The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell. 2005;7:351-62 pubmed
    b>CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer...
  3. Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates J, et al. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 2007;26:2880-9 pubmed
    A number of hormones and growth factors stimulate gene expression by promoting the phosphorylation of CREB (P-CREB), thereby enhancing its association with the histone acetylase paralogs p300 and CBP (CBP/p300)...
  4. de La Fuente C, Gupta M, Klase Z, Strouss K, Cahan P, McCaffery T, et al. Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach. Retrovirology. 2006;3:43 pubmed
    ..Tax transactivates these cellular promoters by interacting with transcription factors such as CREB/ATF, NF-kappaB, and SRF...
  5. Lee J, Kim C, Simon D, Aminova L, Andreyev A, Kushnareva Y, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280:40398-401 pubmed
    Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established...
  6. Ram rez J, Nyborg J. Molecular characterization of HTLV-1 Tax interaction with the KIX domain of CBP/p300. J Mol Biol. 2007;372:958-69 pubmed publisher
    ..Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter...
  7. Trevisan R, Daprai L, Paloschi L, Vajente N, Chieco Bianchi L, Saggioro D. Antiapoptotic effect of human T-cell leukemia virus type 1 tax protein correlates with its creb transcriptional activity. Exp Cell Res. 2006;312:1390-400 pubmed
    ..the action of Tax, in the present study, we investigated the outcome of Tax and two mutants which are inactive in CREB/ATF (M47) or NF-kappaB (M22) pathways, in the control of apoptosis induced by the proapoptotic Bax protein...
  8. Shi Y, Venkataraman S, Dodson G, Mabb A, Leblanc S, Tibbetts R. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004;101:5898-903 pubmed
    ..we describe a signal transduction pathway linking ATM directly to the Ca(2+)/cAMP response element-binding protein, CREB, a transcription factor that regulates cell growth, homeostasis, and survival...
  9. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham J, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A. 2003;100:12147-52 pubmed
    ..A protein, termed transducer of regulated cAMP response element-binding protein (CREB) (TORC1), was identified that activated expression through the variant CRE and consensus CRE sites...
  10. Illario M, Giardino Torchia M, Sankar U, Ribar T, Galgani M, Vitiello L, et al. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood. 2008;111:723-31 pubmed
    ..These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
  11. Sun H, Chung W, Ryu S, Ju Z, Tran H, Kim E, et al. Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila). 2008;1:316-28 pubmed publisher
    ..overexpression in NSCLC cells was abrogated with the knockdown of cyclic AMP-responsive element binding protein (CREB) or nuclear factor kappaB (NF-kappaB)...
  12. Geiger T, Sharma N, Kim Y, Nyborg J. The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. Mol Cell Biol. 2008;28:1383-92 pubmed
    ..Tax function is strictly dependent upon the cellular transcription factor CREB, and together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription...
  13. Screaton R, Conkright M, Katoh Y, Best J, Canettieri G, Jeffries S, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell. 2004;119:61-74 pubmed
    ..pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe a signaling module that mediates the synergistic effects of these pathways on cellular gene ..
  14. Euskirchen G, Royce T, Bertone P, Martone R, Rinn J, Nelson F, et al. CREB binds to multiple loci on human chromosome 22. Mol Cell Biol. 2004;24:3804-14 pubmed
    The cyclic AMP-responsive element-binding protein (CREB) is an important transcription factor that can be activated by hormonal stimulation and regulates neuronal function and development...
  15. Melnikova V, Mourad Zeidan A, Lev D, Bar Eli M. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. J Biol Chem. 2006;281:2911-22 pubmed
    Overexpression of cAMP-response element (CRE)-binding protein (CREB) and activating transcription factor (ATF) 1 contributes to melanoma progression and metastasis at least in part by promoting tumor cell survival and stimulating matrix ..
  16. Spooren A, Kooijman R, Lintermans B, Van Craenenbroeck K, Vermeulen L, Haegeman G, et al. Cooperation of NFkappaB and CREB to induce synergistic IL-6 expression in astrocytes. Cell Signal. 2010;22:871-81 pubmed publisher
    ..Simultaneous induction with isoproterenol and TNF-alpha was moreover associated with combined recruitment of CREB and p65 to the native IL-6 promoter...
  17. Dobroff A, Wang H, Melnikova V, Villares G, Zigler M, Huang L, et al. Silencing cAMP-response element-binding protein (CREB) identifies CYR61 as a tumor suppressor gene in melanoma. J Biol Chem. 2009;284:26194-206 pubmed publisher
    ..progression of melanoma is associated with overexpression and activity of cAMP-response element-binding protein (CREB). However, the mechanism by which CREB contributes to tumor progression and metastasis remains unclear...
  18. Shankar E, Krishnamurthy S, Paranandi R, Basu A. PKCepsilon induces Bcl-2 by activating CREB. Int J Oncol. 2010;36:883-8 pubmed
    ..Knockdown of PKCepsilon decreased phosphorylation of cAMP response element-binding protein (CREB) at Ser133 in MDA-MB-231 cells, and depletion of CREB by siRNA decreased Bcl-2 at both the protein and mRNA levels...
  19. Son J, Lee J, Kim H, Ha H, Lee Z. cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction. Biochem Biophys Res Commun. 2010;398:309-14 pubmed publisher
    cAMP-response-element-binding protein (CREB) signaling has been reported to be associated with cancer development and poor clinical outcome in various types of cancer...
  20. Laneve P, Gioia U, Andriotto A, Moretti F, Bozzoni I, Caffarelli E. A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation. Nucleic Acids Res. 2010;38:6895-905 pubmed publisher
    ..master transcriptional factors RE1-silencing transcription factor (REST) and cAMP-response element binding protein (CREB) on miR-9-2 promoter induces miRNA expression during differentiation...
  21. Comerford K, Leonard M, Karhausen J, Carey R, Colgan S, Taylor C. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A. 2003;100:986-91 pubmed
    ..previously shown to involve phosphorylation-dependent degradation of the cAMP-response element-binding protein (CREB)...
  22. Seo H, Liu D, Bekele B, Kim M, Pisters K, Lippman S, et al. Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer. Cancer Res. 2008;68:6065-73 pubmed publisher
    ..Based on the identification of the transcription factor cyclic AMP response element-binding protein (CREB) as an important regulator of growth of several types of cancers and our recent findings of its importance in ..
  23. Sakamoto K, Frank D. CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res. 2009;15:2583-7 pubmed publisher
    ..One such transcription factor is the cAMP-regulatory element-binding protein (CREB), which can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, ..
  24. Zhang Y, Bharadwaj U, Logsdon C, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010;16:1423-30 pubmed publisher
    ..The activity of cAMP response element-binding protein (CREB) is examined by a promoter activity assay...
  25. Yang C, Li X, Wang Y, Zhao L, Chen W. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 2012;496:8-16 pubmed publisher
    ..in western blot analysis, p300 (encoded by EP300) and its coactivator cAMP response element-binding protein (CREB) level were significantly down-regulated...
  26. Kim Y, Ram rez J, Mick J, Giebler H, Yan J, Nyborg J. Molecular characterization of the Tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in Tax transactivation. J Biol Chem. 2007;282:18750-7 pubmed publisher
    ..elements (CREs), which are recognized by the cellular transcription factor cAMP-response element-binding protein (CREB). Tax binds to GC-rich sequences that immediately flank the CREs...
  27. Ban N, Yamada Y, Someya Y, Ihara Y, Adachi T, Kubota A, et al. Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes. 2000;49:1142-8 pubmed
    ..islets, ATF-2 enhanced glucose-induced insulin promoter activity, whereas cAMP response element-binding protein (CREB) repressed it...
  28. Deak M, Clifton A, Lucocq L, Alessi D. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426-41 pubmed
    ..MSK1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates CREB at Ser133 with a Km value far lower than PKA, MAPKAP-K1(p90Rsk) and MAPKAP-K2...
  29. Xing J, Ginty D, Greenberg M. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996;273:959-63 pubmed
    ..growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription...
  30. Radhakrishnan I, Pérez Alvarado G, Parker D, Dyson H, Montminy M, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997;91:741-52 pubmed
    The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  31. Zhou Q, Gedrich R, Engel D. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. J Virol. 1995;69:4323-30 pubmed
    ..that the mechanism of transcriptional repression by YY1 might involve a direct interaction with members of the ATF/CREB family of transcription factors...
  32. Arias J, Alberts A, Brindle P, Claret F, Smeal T, Karin M, et al. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994;370:226-9 pubmed
    ..of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB at Ser 133...
  33. Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb M. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 1996;15:4629-42 pubmed
    ..regulates gene expression at a cyclic-AMP response element (CRE) by stimulating the transcriptional activity of CREB. The activation of CREB is prevented by a dominant negative mutant of Ras and triggered via the same site (Ser133) ..
  34. Chrivia J, Kwok R, Lamb N, Hagiwara M, Montminy M, Goodman R. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993;365:855-9 pubmed
    ..Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A...
  35. Guo J, Liu Z, Dai H, Zhu Z, Wang H, Yang C, et al. Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression. Int J Neurosci. 2014;124:22-9 pubmed publisher
    Research has increasingly focused on the role of the cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in learning and memory, particularly its role in cognitive disorders and neurodegeneration, such as ..
  36. Beaumont T, Yao B, Shah A, Kapatos G, Loeb J. Layer-specific CREB target gene induction in human neocortical epilepsy. J Neurosci. 2012;32:14389-401 pubmed publisher
    ..The transcriptome that emerged strongly implicates MAPK signaling and CREB-dependent transcription, with 74% of differentially expressed genes containing a cAMP response element (CRE) in ..
  37. Boone D, Sell S, Micci M, Crookshanks J, Parsley M, Uchida T, et al. Traumatic brain injury-induced dysregulation of the circadian clock. PLoS ONE. 2012;7:e46204 pubmed publisher
    ..clock output is mediated by some of the same molecular signaling cascades that regulate memory formation (cAMP/MAPK/CREB), cognitive problems reported by TBI survivors may be related to injury-induced dysregulation of the circadian ..
  38. Chun H, Hao W, Honghai Z, Ning L, Yasong W, Chen D. CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway. Brain Res. 2009;1257:75-88 pubmed publisher
    ..culture following treatment with CCL3L1 plus gp120; (ii) CCL3L1 induces cell survival via phosphorylation of CREB by way of the PKA and CaMKI/CaMKIV cell signaling pathways; (iii) transcription of the cell survival gene bcl-2 is ..
  39. Han A, Currie H, Loos M, Scardoni G, Miller J, Prince N, et al. The impact of cytokine responses in the intra- and extracellular signaling network of a traumatic injury. Cytokine. 2018;106:136-147 pubmed publisher
    ..comprised of cytokines (IL-1α, IL-1ß, IL-2, IL-6, TNF-α, MIP-1α), intracellular proteins (Akt, c-Jun, CREB, ERK1/2, JNK, MEK1, p38, p53, p90RSK), phosphorylated proteins (p-Akt, p-c-Jun, p-CREB, p-ERK1/2, p-GSK-3α/ß, ..
  40. Li Y, Yu M, Zhao B, Wang Y, Zha Y, Li Z, et al. Clonidine preconditioning improved cerebral ischemia-induced learning and memory deficits in rats via ERK1/2-CREB/ NF-?B-NR2B pathway. Eur J Pharmacol. 2018;818:167-173 pubmed publisher
    ..Moreover, protein expression levels of NMDAR2B (NR2B)/ phosphor - NR2B, ERK1/2/phosphor- ERK1/2, CREB/phosphor-CREB and NF-?B/phosphor-NF-?B in the cortex and hippocampus of the rats were assayed by western blotting...
  41. Yi L, Wu Q, Chen N, Song G, Wang C, Zou Q, et al. Valproate Plays a Protective Role against Migraine by Inhibiting Protein Kinase C Signalling in Nitroglycerin-treated Mice. Basic Clin Pharmacol Toxicol. 2017;: pubmed publisher
    ..Together, we demonstrated that VP prevented damage due to migraine by inhibiting PKC signalling in NTG-injected mice, which may provide a basis for investigating the clinical treatment of migraine...
  42. Pandey S, Kyzar E, Zhang H. Epigenetic basis of the dark side of alcohol addiction. Neuropharmacology. 2017;122:74-84 pubmed publisher
    ..response which is associated with the opening of chromatin due to increased histone acetylation, increased CREB binding protein (CBP) levels, and histone deacetylase (HDAC) inhibition...
  43. Sahu S, Ganguly R, Raman P. Leptin augments recruitment of IRF-1 and CREB to thrombospondin-1 gene promoter in vascular smooth muscle cells in vitro. Am J Physiol Cell Physiol. 2016;311:C212-24 pubmed publisher
    ..of transcription factors, interferon regulatory factor-1 (IRF-1) and cAMP response element-binding protein (CREB), to the distal fragment of the THBS1 promoter in response to leptin...
  44. Guan C, Cui Y, Sun G, Yu F, Tang C, Li Y, et al. Role of CREB in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Regul Pept. 2009;153:64-9 pubmed publisher
    ..In the present study, we further investigated the role of cAMP Response Element Binding Protein (CREB) in VIP-promoted protective effects in mechanical-damaged HBECs...
  45. Tomoshige S, Naito M, Hashimoto Y, Ishikawa M. Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules. Org Biomol Chem. 2015;13:9746-50 pubmed publisher
    ..HaloTag-binding degradation inducers can be synthesized easily, and are expected to be useful as biological tools for pan-degradation of HaloTag-fused proteins. ..
  46. Jabaris S, Sumathy H, Girish R, Narayanan S, Sugumar M, Saravana Babu C, et al. Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system. Brain Res. 2015;1622:279-91 pubmed publisher
    ..Our present findings suggested that PDE-4 inhibitors ameliorate hypertension-induced learning impairment via cAMP/CREB signaling that regulates BDNF expression downstream in the rat hippocampus.
  47. Cho K, Cho M, Seo J, Peak J, Kong K, Yoon S, et al. Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease. Aging Cell. 2015;14:878-86 pubmed publisher
    ..cAMP-response element-binding protein (CREB) is a transcription factor involved in the molecular switch that converts short-term to long-term memory...
  48. Lee N, Kwon J, Kim Y, Kim S, Park S, Xu W, et al. Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget. 2015;6:30130-48 pubmed publisher
    ..cyclin D1 and p-Rb while upregulating p21 and p27, and that VRK1 depletion downregulated phosphorylation of CREB, a transcription factor regulating CCND1...
  49. Rashid M, Kim H. N-Docosahexaenoylethanolamine ameliorates ethanol-induced impairment of neural stem cell neurogenic differentiation. Neuropharmacology. 2016;102:174-85 pubmed publisher
    ..to ethanol (25-50 mM) for 4 days dose-dependently decreased the number of Tuj-1 positive neurons and PKA/CREB phosphorylation with a concomitant reduction of cellular cAMP...
  50. Siahposht Khachaki A, Fatahi Z, Yans A, Khodagholi F, Haghparast A. Involvement of AMPA/Kainate Glutamate Receptor in the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference: A Behavioral and Molecular Study. Cell Mol Neurobiol. 2017;37:315-328 pubmed publisher
    ..In addition, several lines of study have indicated that cAMP response element-binding protein (CREB) and c-fos have important role in morphine-induced conditioned place preference (CPP) induced by drugs of abuse, ..
  51. Melgarejo da Rosa M, Yuanxiang P, Brambilla R, Kreutz M, Karpova A. Synaptic GluN2B/CaMKII-? Signaling Induces Synapto-Nuclear Transport of ERK and Jacob. Front Mol Neurosci. 2016;9:66 pubmed publisher
    ..The synapto-nuclear messenger Jacob couples NMDAR-dependent Ca(2+)-signaling to CREB-mediated gene expression...
  52. Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, et al. Ethanol suppresses PGC-1? expression by interfering with the cAMP-CREB pathway in neuronal cells. PLoS ONE. 2014;9:e104247 pubmed publisher
    ..intracellular cAMP levels, and thus depletes phosphorylation of cAMP-response element binding protein (p-CREB), the key transcription factor that regulates transcription of PGC-1? gene...
  53. Sandoval S, Kraus C, Cho E, Cho M, Bies J, Manara E, et al. Sox4 cooperates with CREB in myeloid transformation. Blood. 2012;120:155-65 pubmed publisher
    The cAMP response element-binding protein (CREB) is a nuclear transcription factor that is critical for normal and neoplastic hematopoiesis...
  54. Huang Y, Chang C, Huang T, Hsieh Y, Shih H. Daxx interacts with and modulates the activity of CREB. Cell Cycle. 2012;11:99-108 pubmed publisher
    The phosphorylation of cAMP response element-binding protein (CREB) induced by the cAMP-dependent protein kinase A (PKA) elicits the recruitment of CREB-binding protein (CBP) for activating cAMP responsive gene expression...
  55. Ray R, Jepson C, Wileyto P, Patterson F, Strasser A, Rukstalis M, et al. CREB1 haplotypes and the relative reinforcing value of nicotine. Mol Psychiatry. 2007;12:615-7 pubmed
  56. Kim Y, Cho S, Kim S, Jang H, Seo Y. Effects of Extremely Low Frequency Electromagnetic Fields on Melanogenesis through p-ERK and p-SAPK/JNK Pathways in Human Melanocytes. Int J Mol Sci. 2017;18: pubmed publisher
    ..Phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB) levels were higher than controls in cells exposed to ELF-EMFs at 50-75 Hz...
  57. Mayr B, Guzman E, Montminy M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. J Biol Chem. 2005;280:15103-10 pubmed
    We have examined the dynamics of cAMP-response element-binding protein (CREB) binding to chromatin in live cells using fluorescence recovery after photobleaching (FRAP)...
  58. Sun Y, Byon C, Yang Y, Bradley W, Dell Italia L, Sanders P, et al. Dietary potassium regulates vascular calcification and arterial stiffness. JCI Insight. 2017;2: pubmed publisher
    ..the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification...
  59. Ciani E, Guidi S, Della Valle G, Perini G, Bartesaghi R, Contestabile A. Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation. J Biol Chem. 2002;277:49896-902 pubmed
    The transcription factor cAMP-response element-binding protein (CREB) mediates survival in many cells, including neurons...
  60. Kronke G, Bochkov V, Huber J, Gruber F, Bluml S, Furnkranz A, et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J Biol Chem. 2003;278:51006-14 pubmed
    ..The cAMP-responsive element-binding protein (CREB) was phosphorylated via these pathways in response to OxPAPC treatment and expression of a dominant-negative mutant ..
  61. Pearce A, Sanders L, Brighton P, Rana S, Konje J, Willets J. Reciprocal regulation of ?2-adrenoceptor-activated cAMP response-element binding protein signalling by arrestin2 and arrestin3. Cell Signal. 2017;38:182-191 pubmed publisher
    ..In the myometrium cAMP-driven modulation of cell phenotype is facilitated by CREB activity, however despite the importance of CREB signalling in the promotion of myometrial quiescence during ..
  62. Wang X, Li W, Williams M, Terada N, Alessi D, Proud C. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 2001;20:4370-9 pubmed
    ..In contrast, regulation of eEF2 by stimuli that activate Erk is insensitive to rapamycin, but blocked by inhibitors of MEK/Erk signalling, consistent with the involvement of p90(RSK1). ..
  63. Namkoong S, Lee K, LEE J, Park R, Lee E, Jang I, et al. The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase. Autophagy. 2015;11:756-68 pubmed publisher
    The PKA-CREB signaling pathway is involved in many cellular processes including autophagy...
  64. Lee J, Ryu H, Kim J, Jung T, Park S, Lee Y. Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells. Arch Pharm Res. 2017;40:807-817 pubmed publisher
    ..transcription factor (MITF) in B16F10 cells, while it did not affect cAMP response element binding protein (CREB) phosphorylation. Additionally, gomisin N activated AKT phosphorylation, which inhibits MITF expression...
  65. Sonntag T, Moresco J, Vaughan J, Matsumura S, Yates J, Montminy M. Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. PLoS ONE. 2017;12:e0173013 pubmed publisher
    ..messenger cAMP stimulates cellular gene expression via the PKA-mediated phosphorylation of the transcription factor CREB and through dephosphorylation of the cAMP-responsive transcriptional coactivators (CRTCs)...
  66. Ma J, Wang L, Yang Y, Qiao Z, Fang D, Qiu X, et al. GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population. PLoS ONE. 2017;12:e0170994 pubmed publisher
    ..study we investigated the interaction of variations in the G-protein beta 3 subunit (GNB3) and cAMP response element binding protein 1 (CREB1) genes with negative life events in the pathogenesis of MD...
  67. Shi F, Shang L, Yang L, Jiang Y, Wang X, Hao J, et al. Neuropilin-1 contributes to esophageal squamous cancer progression via promoting P65-dependent cell proliferation. Oncogene. 2017;: pubmed publisher
    ..NRP1 regulates P65 transcription by activating cAMP responsive element binding protein (CREB)...
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