CR1

Summary

Gene Symbol: CR1
Description: complement C3b/C4b receptor 1 (Knops blood group)
Alias: C3BR, C4BR, CD35, complement receptor type 1, C3-binding protein, C3b/C4b receptor, CD35 antigen, Knops blood group antigen, complement component (3b/4b) receptor 1 (Knops blood group)
Species: human
Products:     CR1

Top Publications

  1. Rao N, Ferguson D, Lee S, Telen M. Identification of human erythrocyte blood group antigens on the C3b/C4b receptor. J Immunol. 1991;146:3502-7 pubmed
    ..Screening of red cells lacking certain high titer low avidity Ag demonstrated markedly diminished CR1 expression on McC(d-) and Kn/McC "null" (Kn(a-)McC(a-b-c-d-e-f-] erythrocytes...
  2. Herrera A, Xiang L, Martin S, Lewis J, Wilson J. Analysis of complement receptor type 1 (CR1) expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations. Clin Immunol Immunopathol. 1998;87:176-83 pubmed
    b>CR1 expression on erythrocytes (E) is regulated by an element that is tightly linked in Caucasians to the site of an RFLP of the CR1 gene. Genomic HindIII fragments of 7.4 and 6...
  3. Mrazek F, Kvezereli M, Garr E, Kubistova Z, Kriegova E, Fillerova R, et al. Complement receptor 1 single nucleotide polymorphisms in Czech and Dutch patients with sarcoidosis. Tissue Antigens. 2008;71:77-80 pubmed
    A single nucleotide polymorphism (SNP) C5507G of the complement receptor 1 (CR1) gene has been associated with genetic susceptibility to sarcoidosis in an Italian population...
  4. Tas S, Klickstein L, Barbashov S, Nicholson Weller A. C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion. J Immunol. 1999;163:5056-63 pubmed
    Previously, we showed that soluble C1q bound specifically to CR1 on transfected cells. If the CR1-C1q interaction were to participate in immune complex clearance, then this interaction should support E adhesion...
  5. Wilson J, Murphy E, Wong W, Klickstein L, Weis J, Fearon D. Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes. J Exp Med. 1986;164:50-9 pubmed
    A genetic basis for the regulation of the number of CR1 on E of different normal individuals was investigated by probing Southern blots of their genomic DNA with a 0.75-kb fragment of CR1 cDNA...
  6. Lambert J, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 2009;41:1094-9 pubmed publisher
    ..86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) and the other within CR1, encoding the complement component (3b/4b) receptor 1, on chromosome 1 (rs6656401, OR = 1.21, 95% CI 1.14-1...
  7. Nuutila J, Jalava Karvinen P, Hohenthal U, Kotilainen P, Pelliniemi T, Nikoskelainen J, et al. Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections. Hum Immunol. 2013;74:522-30 pubmed publisher
    ..In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy ..
  8. He J, Xi J, Ren Z, Qin H, Zhang Y, Zeng Y, et al. Complement receptor 1 expression in peripheral blood mononuclear cells and the association with clinicopathological features and prognosis of nasopharyngeal carcinoma. Asian Pac J Cancer Prev. 2012;13:6527-31 pubmed
    Complement receptor 1 (CR1) is induced by Epstein-Barr virus (EBV) and may be a potential biomarker of nasopharyngeal carcinoma (NPC)...
  9. Klickstein L, Wong W, Smith J, Weis J, Wilson J, Fearon D. Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins. J Exp Med. 1987;165:1095-112 pubmed
    10 overlapping CR1 cDNA clones that span 5.5 kb were isolated from a tonsillar library and sequenced in whole or in part. A single long open reading frame beginning at the 5' end of the clones and extending 4...

More Information

Publications78

  1. Wagner C, Ochmann C, Schoels M, Giese T, Stegmaier S, Richter R, et al. The complement receptor 1, CR1 (CD35), mediates inhibitory signals in human T-lymphocytes. Mol Immunol. 2006;43:643-51 pubmed
    ..In the present study we investigated the effect of antibodies to CR1 on T-cell lines and peripheral T-cells of healthy donors, respectively...
  2. Sinha S, Jha G, Anand P, Qidwai T, Pati S, Mohanty S, et al. CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity. Hum Immunol. 2009;70:244-50 pubmed publisher
    Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions...
  3. Mahajan R, Narain K, Mahanta J. Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India. Indian J Med Res. 2011;133:662-4 pubmed
    ..to understand the pathogenesis of anaemia we studied expression level of RBC complement regulatory proteins, CR1 (CD35), CD55 and CD59 with haemoglobin status in a group of malaria cases from Assam, Goa and Chennai, and in healthy ..
  4. Kullo I, Ding K, Shameer K, McCarty C, Jarvik G, Denny J, et al. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. Am J Hum Genet. 2011;89:131-8 pubmed publisher
    ..A nonsynonymous SNP, rs6691117 (Val?IIe), in the complement receptor 1 gene (CR1) was associated with ESR (discovery cohort p = 7 × 10(-12), replication cohort p = 3 × 10(-14), combined cohort p ..
  5. Wong W, Cahill J, Rosen M, Kennedy C, Bonaccio E, Morris M, et al. Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele. J Exp Med. 1989;169:847-63 pubmed
    Structural and quantitative polymorphisms have been described in human CR1. In the former, the S allotype is larger than the F allotype by 40-50 kD, the size of a long homologous repeat (LHR). In the latter, homozygotes for a 7...
  6. Teeranaipong P, Ohashi J, Patarapotikul J, Kimura R, Nuchnoi P, Hananantachai H, et al. A functional single-nucleotide polymorphism in the CR1 promoter region contributes to protection against cerebral malaria. J Infect Dis. 2008;198:1880-91 pubmed publisher
    Although the level of erythrocyte complement receptor type 1 (E-CR1) expression in patients with malaria has been extensively studied, whether the level of expression of E-CR1 is associated with severe malaria remains controversial...
  7. Lapin Z, Höppener C, Gelbard H, Novotny L. Near-field quantification of complement receptor 1 (CR1/CD35) protein clustering in human erythrocytes. J Neuroimmune Pharmacol. 2012;7:539-43 pubmed publisher
    We investigate the distribution of the membrane protein complement receptor 1 (CR1/CD35) in human erythrocyte membrane ghosts using scanning near-field optical microscopy...
  8. Yuan Y, Zhao M, Yu J. [Association between genetic polymorphism of erythrocyte CR1 and the susceptibility of idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2011;34:841-5 pubmed
    To explore the association between the erythrocyte CR1 genomic density polymorphism, A3650G site polymorphism and the susceptibility of idiopathic pulmonary fibrosis (IPF); and to investigate the correlation between the HindIII density ..
  9. Soares S, Abe Sandes K, Nascimento Filho V, Nunes F, Silva W. Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil. Genet Mol Res. 2008;7:1011-9 pubmed
    ..The Lys1590Glu and Arg1601Gly polymorphisms in the complement receptor type 1 (CR1) were analyzed by DNA sequencing...
  10. Cockburn I, Rowe J. Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene. Int J Immunogenet. 2006;33:17-20 pubmed
    Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of ..
  11. Xiang L, Rundles J, Hamilton D, Wilson J. Quantitative alleles of CR1: coding sequence analysis and comparison of haplotypes in two ethnic groups. J Immunol. 1999;163:4939-45 pubmed
    The quantitative expression of complement receptor type 1 (CR1) on erythrocytes is regulated by two CR1 alleles that differ in having genomic HindIII fragments of either 7.4 or 6...
  12. Boiocchi C, Zorzetto M, Sbarsi I, Pirotta A, Schirinzi S, Falcone C, et al. CR1 genotype and haplotype involvement in coronary artery disease: the pivotal role of hypertension and dyslipidemia. Int J Mol Med. 2009;24:181-7 pubmed
    ..Thus, there is evidence supporting the role of complement activation in atherogenesis. Complement receptor 1 (CR1) is a membrane protein found on different cells involved in various activities of the complement system...
  13. Fernandez Arias C, Lopez J, Hernandez Perez J, Bautista Ojeda M, Branch O, Rodriguez A. Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization. J Immunol. 2013;190:3363-72 pubmed publisher
    Complement receptor 1 (CR1) expressed on the surface of phagocytic cells binds complement-bound immune complexes (IC), playing an important role in the clearance of circulating IC...
  14. Klickstein L, Bartow T, Miletic V, Rabson L, Smith J, Fearon D. Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis. J Exp Med. 1988;168:1699-717 pubmed
    Complementary DNA clones encoding the NH2-terminal region of human CR1 have been isolated and sequenced...
  15. Cockburn I, Mackinnon M, O Donnell A, Allen S, Moulds J, Baisor M, et al. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Proc Natl Acad Sci U S A. 2004;101:272-7 pubmed
    ..Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes...
  16. Srivastava A, Mittal B. Complement receptor 1 (A3650G RsaI and intron 27 HindIII) polymorphisms and risk of gallbladder cancer in north Indian population. Scand J Immunol. 2009;70:614-20 pubmed publisher
    Decreased expression due to genetic variations in complement receptor 1 (CR1) on erythrocytes might result in reduced clearance of immune complexes, conferring interindividual variation for gallbladder cancer (GBC) susceptibility...
  17. Zhang Q, Yu J, Zhu Q, Zhang W, Wu Z, Miao D, et al. Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease. Brain Res. 2010;1348:216-21 pubmed publisher
    ..Complement receptor 1 (CR1) is thought to contribute to Abeta clearance...
  18. Carrasquillo M, Belbin O, Hunter T, Ma L, Bisceglio G, Zou F, et al. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol. 2010;67:961-4 pubmed publisher
    To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease. Follow-up case-control association study. The Mayo Clinics at Jacksonville, Florida, and Rochester, Minnesota...
  19. Rout R, Dhangadamajhi G, Mohapatra B, Kar S, Ranjit M. High CR1 level and related polymorphic variants are associated with cerebral malaria in eastern-India. Infect Genet Evol. 2011;11:139-44 pubmed publisher
    The complement receptor 1 (CR1/CD35) protein acts as the major rosetting receptor in Plasmodium falciparum infection and several genetic variants of CR1 gene have been shown to be associated with quantitative expression of erythrocyte CR1 ..
  20. Moulds J, Zimmerman P, Doumbo O, Kassambara L, Sagara I, Diallo D, et al. Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Blood. 2001;97:2879-85 pubmed
    Complement receptor 1 (CR1) has been implicated in rosetting of uninfected red blood cells to Plasmodium falciparum-infected cells, and rosette formation is associated with severe malaria...
  21. Wong W, Farrell S. Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function. J Immunol. 1991;146:656-62 pubmed
    Human CR1 is composed of tandem long homologous repeating (LHR) segments that encode separate binding sites for C3b or C4b...
  22. Rowe J, Moulds J, Newbold C, Miller L. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature. 1997;388:292-5 pubmed
    ..falciparum clone is PfEMP1, encoded by a specific var gene. We also report that complement-receptor 1 (CR1) on erythrocytes plays a role in the formation of rosettes and that erythrocytes with a common African CR1 ..
  23. Liu D, Niu Z. The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35). Immunopharmacol Immunotoxicol. 2009;31:524-35 pubmed publisher
    ..b>Complement receptor type 1 (CR1), the receptor for C3b/C4b complement peptides, has emerged as a molecule of immense interest in ..
  24. Wong W, Wilson J, Fearon D. Genetic regulation of a structural polymorphism of human C3b receptor. J Clin Invest. 1983;72:685-93 pubmed
    Two forms of the human C3b receptor (C3bR), which have relative molecular weights (Mr) of 250,000 and 260,000 and are designated F and S, respectively, have been identified in specific immunoprecipitates from erythrocytes and leukocytes ..
  25. Rowe J, Raza A, Diallo D, Baby M, Poudiougo B, Coulibaly D, et al. Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Genes Immun. 2002;3:497-500 pubmed
    Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined, and in Caucasian populations is linked to high (H) and low (L) expression alleles identified by a HindIII restriction fragment length polymorphism (..
  26. Awandare G, Spadafora C, Moch J, Dutta S, Haynes J, Stoute J. Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes. Mol Biochem Parasitol. 2011;177:57-60 pubmed publisher
    ..However, we recently reported that complement receptor 1 (CR1) is a SA-independent invasion receptor of many laboratory strains of P. falciparum...
  27. Zorzetto M, Bombieri C, Ferrarotti I, Medaglia S, Agostini C, Tinelli C, et al. Complement receptor 1 gene polymorphisms in sarcoidosis. Am J Respir Cell Mol Biol. 2002;27:17-23 pubmed
    ..Erythrocyte (E) complement receptor 1 (CR1) is a membrane protein mediating the transport of immune complexes (ICs) to phagocytes, and at least three ..
  28. Jozsi M, Prechl J, Bajtay Z, Erdei A. Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes. J Immunol. 2002;168:2782-8 pubmed
    ..In the present study, we aimed to elucidate the role of human complement receptor type 1 (CR1), the other C3-receptor on B cells. As ligand, aggregated C3 and aggregated C3(H(2)O), i.e...
  29. Moulds J, Nickells M, Moulds J, Brown M, Atkinson J. The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera. J Exp Med. 1991;173:1159-63 pubmed
    ..incidence blood group antigens were screened by an antiglobulin test with a monoclonal antibody to human complement receptor type 1 (CR1; C3b/C4b receptor; CD35)...
  30. Ahearn J, Fearon D. Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv Immunol. 1989;46:183-219 pubmed
  31. Jun G, Naj A, Beecham G, Wang L, Buros J, Gallins P, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010;67:1473-84 pubmed publisher
    To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes...
  32. Ghiran I, Barbashov S, Klickstein L, Tas S, Jensenius J, Nicholson Weller A. Complement receptor 1/CD35 is a receptor for mannan-binding lectin. J Exp Med. 2000;192:1797-808 pubmed
    ..Complement C1q, which is homologous to MBL, binds to complement receptor 1 (CR1/CD35), and thus we investigated whether CR1 also functions as the MBL receptor...
  33. Vik D, Wong W. Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele. J Immunol. 1993;151:6214-24 pubmed
    The genes for human complement receptor type 1 (CR1) F and S alleles have been cloned and span a region of 133-160 kb on chromosome 1. The F allele was found to comprise 39 exons and the S allele contains an additional 8 exons...
  34. Holers V, Chaplin D, Leykam J, Gruner B, Kumar V, Atkinson J. Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism. Proc Natl Acad Sci U S A. 1987;84:2459-63 pubmed
    The human C3b/C4b receptor (CR1) is a Mr approximately equal to 200,000 single-chain integral membrane glycoprotein of human erythrocytes and leukocytes...
  35. Biffi A, Anderson C, Desikan R, Sabuncu M, Cortellini L, Schmansky N, et al. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol. 2010;67:677-85 pubmed publisher
    ..04) on all analyzed neuroimaging measures. The GWAS-validated variants at the CR1 and PICALM loci and markers at 2 novel loci (BIN1 and CNTN5) showed association with multiple magnetic resonance ..
  36. Weis J, Morton C, Bruns G, Weis J, Klickstein L, Wong W, et al. A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32. J Immunol. 1987;138:312-5 pubmed
  37. Brammer J, Saliba R, Jorgensen J, Ledesma C, Gaballa S, Poon M, et al. Multi-center analysis of the effect of T-cell acute lymphoblastic leukemia subtype and minimal residual disease on allogeneic stem cell transplantation outcomes. Bone Marrow Transplant. 2017;52:20-27 pubmed publisher
    ..Patients transplanted in first complete remission (CR1) had a 3-year OS of 62% versus those transplanted in CR2 or greater (24%) (hazards ratio 1.6, P=0.2)...
  38. Sutti S, Heymann F, Bruzzì S, Peusquens J, Trautwein C, Albano E, et al. CX3CR1 modulates the anti-inflammatory activity of hepatic dendritic cells in response to acute liver injury. Clin Sci (Lond). 2017;: pubmed publisher
    The chemokine fractalkine (CX3CL1) and its receptor CX3CR1 are known to mediate leukocyte chemotaxis, adhesion and survival...
  39. Mengel From J, Christensen K, McGue M, Christiansen L. Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old. Neurobiol Aging. 2011;32:554.e7-11 pubmed publisher
    ..Better performance was found (p = 0.024), explaining 1.4% of the mean variation in cognitive composite score in men. These alleles correspond to the minor alleles initially found more frequent in controls than in cases of AD. ..
  40. Wang J, Yao B, Guo M, Qiao J, Sun Q, Hu K, et al. [Characteristics and Prognosis of 24 Cases of Primary Acute Myeloid Leukemia with Trisomy 8]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:655-61 pubmed publisher
    ..Among 20 cases of non-M3, 12 cases achieved CR1 (60%), 4 cases achieved partial response (PR) (20%), 4 cases did not respond (NR); 5 cases relapsed in follow-up ..
  41. Yoon J, Yhim H, Kwak J, Ahn J, Yang D, Lee J, et al. Minimal residual disease-based effect and long-term outcome of first-line dasatinib combined with chemotherapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia. Ann Oncol. 2016;27:1081-8 pubmed publisher
    ..9%), 15 (30.7%), and 11 (22.4%), respectively. Thirty-nine patients (76.5%) underwent allogeneic SCT in CR1. After a median follow-up of 54 months, the 4-year cumulative incidence of relapse and disease-free survival (DFS) ..
  42. Malik M, Parikh I, Vasquez J, Smith C, Tai L, Bu G, et al. Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener. 2015;10:52 pubmed publisher
    ..We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE...
  43. Richards K, Wasson C, Watherston O, Doble R, Blair G, Wittmann M, et al. The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes. Sci Rep. 2015;5:12922 pubmed publisher
    ..Inhibition of imiquimod induced cytokine production required residues in the CR1 and CR3 regions of E7 and resulted in reduced nuclear translocation and acetylation of the p65 sub-unit of NFκB...
  44. Schmidt C, Wolff M, von Ahsen N, Lange K, Friede T, Zerr I. CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. J Clin Neurosci. 2014;21:1705-8 pubmed publisher
    ..snp in ace, apoe, bin1, clu, cr1, cst3, exoc3l2, gwa14q32...
  45. Chen Y, Li S, Lane A, Connolly C, Del Rio C, Valles B, et al. Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia. Biol Blood Marrow Transplant. 2014;20:2042-8 pubmed publisher
    ..Twenty-two patients were enrolled (status at HSCT: first complete remission [CR1], n = 16; second complete remission [CR2], n = 3; refractory, n = 3)...
  46. Kim S, Shin D, Kim S, Lee M, Kim E. Aberrant DNA methylation-induced gene inactivation is associated with the diagnosis and/or therapy of T-cell leukemias. Leuk Res. 2016;47:116-22 pubmed publisher
    ..We identify nine genes (CLEC4E, CR1, DBC1, EPO, HAL-DOA, IGF2, IL12B, ITGA1, and LMX1B) that are significantly hypermethylated in T-cell leukemias cell ..
  47. Gaballa S, Saliba R, Oran B, Brammer J, Chen J, Rondon G, et al. Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation. Am J Hematol. 2017;92:331-337 pubmed publisher
    ..Disease status at transplant was: first or second complete remission (CR1/CR2, n = 119), high-risk CR (third or subsequent CR, marrow hypoplasia, or incomplete count recovery) ..
  48. Kumar P, Arun V, Lokeswari T. Cloning of BBTV (Banana Bunchy Top Virus) components and screening of BBTV using functionalized gold nanoparticles. 3 Biotech. 2017;7:225 pubmed publisher
    ..detection method (AuNP probe assay) using gold nanoparticles (AuNPs) functionalized with an ssDNA-thiolated probe (CR1). This method is based on the hybridization of the functionalized AuNPs with the target DNA (BBTV)...
  49. Ogembo J, Kannan L, Ghiran I, Nicholson Weller A, Finberg R, Tsokos G, et al. Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor. Cell Rep. 2013;3:371-85 pubmed publisher
    ..On normal resting B cells, CD21 forms two membrane complexes: one with CD19 and another with CD35. Whereas the CD21/CD19 complex is widely retained on immortalized and B cell tumor lines, the related complement-..
  50. Dykman T, Hatch J, Atkinson J. Polymorphism of the human C3b/C4b receptor. Identification of a third allele and analysis of receptor phenotypes in families and patients with systemic lupus erythematosus. J Exp Med. 1984;159:691-703 pubmed
    We have isolated C3bR from surface-labeled erythrocytes of 180 normal individuals and 45 patients with SLE...
  51. Furtado P, Huang C, Ihyembe D, Hammond R, Marsh H, Perkins S. The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands. J Mol Biol. 2008;375:102-18 pubmed
    Human complement receptor type 1 (CR1, CD35) is a type I membrane-bound glycoprotein that belongs to the regulators of complement activity (RCA) family...
  52. Hing S, Day A, Linton S, Ripoche J, Sim R, Reid K, et al. Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes. Ann Hum Genet. 1988;52:117-22 pubmed
    ..Using cDNA probes for Factor H (FH) and C4 binding protein (C4BP) on a panel of somatic cell hybrids, we show that both of these genes map to the long arm of chromosome 1. ..
  53. Haberz P, Arai M, Martinez Yamout M, Dyson H, Wright P. Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP. Protein Sci. 2016;25:2256-2267 pubmed publisher
    ..three homologous binding sites for the NCBD, one in the N-terminal region and two within conserved region 1 (CR1) of E1A...
  54. Hourcade D, Miesner D, Bee C, Zeldes W, Atkinson J. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. J Biol Chem. 1990;265:974-80 pubmed
    Human C3b/C4b receptor or complement receptor type one (CR1) is one of a family of receptor and regulatory glycoproteins that are encoded at a single genetic region (1q32) and are composed largely of a tandemly repeated motif (short ..
  55. Khan R, Maduray K, Moodley J, Naicker T. Activation of CD35 and CD55 in HIV associated normal and pre-eclamptic pregnant women. Eur J Obstet Gynecol Reprod Biol. 2016;204:51-6 pubmed publisher
    ..Therefore, the purpose of this study was to investigate the expression of complement regulatory (Creg) proteins (CD35 and CD55) in HIV associated normal and pre-eclamptic pregnancies...
  56. Eder S, Labopin M, Finke J, Bunjes D, Olivieri A, Santarone S, et al. Safety and efficacy of thiotepa-based conditioning for allogeneic transplantation in AML: a survey from the ALWP of the EBMT. Bone Marrow Transplant. 2017;52:238-244 pubmed publisher
    ..Disease status at the time of transplantation was CR1 in 50%, CR2+ in 23.5% and advanced disease in 26.5%...
  57. Antunez C, Boada M, Lopez Arrieta J, Moreno Rey C, Hernandez I, Marin J, et al. Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease. Alzheimers Dement. 2011;7:e124-9 pubmed publisher
    ..252, P < 2.99E-8) and suggests the existence of between-study heterogeneity (P < .05). We concluded that the complement receptor 1 gene may contribute to AD risk, although its effect size could be smaller than previously estimated. ..
  58. Sassi C, Nalls M, Ridge P, Gibbs J, Ding J, Lupton M, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging. 2016;46:235.e1-9 pubmed publisher
    ..and low-frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly controls of ..
  59. Langeggen H, Berge K, Johnson E, Hetland G. Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro. Inflammation. 2002;26:103-10 pubmed
    ..receptors on human umbilical vein endothelial cells (HUVEC) and found that they express complement receptor 1 (CR1, CD35) and complement receptor 4 (CR4, CD11c/CD18), but not complement receptor 3 (CR3, CD11b/CD18)...
  60. Clements E, Das R, Li L, Lampen Kelley P, Phan M, Keppens V, et al. Critical Behavior and Macroscopic Phase Diagram of the Monoaxial Chiral Helimagnet Cr1/3NbS2. Sci Rep. 2017;7:6545 pubmed publisher
    ..An analysis of the universal behavior of ΔS M(T,H) experimentally demonstrates for the first time the first-order nature of the onset of chiral ordering. ..
  61. Chung S, Kim M, Kim Y, Kim J, You S, Jang E, et al. CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease. J Neurol Sci. 2014;339:91-6 pubmed publisher
    ..We aimed to investigate the association between top hits of genome-wide association studies (GWAS) and specific cognitive domains in AD patients...
  62. Hodgson U, Tukiainen P, Laitinen T. The polymorphism C5507G of complement receptor 1 does not explain idiopathic pulmonary fibrosis among the Finns. Respir Med. 2005;99:265-7 pubmed
    ..We conclude that G5507 is not a susceptibility allele for idiopathic pulmonary fibrosis among Finnish patients. ..
  63. Petty A, Green C, Poole J, Daniels G. Analysis of Knops blood group antigens on CR1 (CD35) by the MAIEA test and by immunoblotting. Transfus Med. 1997;7:55-62 pubmed
    Kna, McCa, Sla and Yka are red cell antigens of relatively high frequency, located on complement receptor 1 (CR1, CD35). Antibodies to these Knops system antigens are not uncommon...
  64. Naitza S, Porcu E, Steri M, Taub D, Mulas A, Xiao X, et al. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 2012;8:e1002480 pubmed publisher
    ..54×10(-08)) loci. Confirmatory evidence was found for IL-6 in the IL-6R gene (rs4129267); for ESR at CR1 (rs12567990) and TMEM57 (rs10903129); for MCP-1 at DARC (rs12075); and for hsCRP at CRP (rs1205), HNF1A (rs225918), ..
  65. Hamilton G, Evans K, MacIntyre D, Deary I, Dominiczak A, Smith B, et al. Alzheimer's disease risk factor complement receptor 1 is associated with depression. Neurosci Lett. 2012;510:6-9 pubmed publisher
    Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease...
  66. Buraczynska M, Ksiazek P, Wacinski P, Zukowski P, Dragan M, Bednarek Skublewska A. Complement receptor 1 gene polymorphism and cardiovascular disease in dialyzed end-stage renal disease patients. Hum Immunol. 2010;71:878-82 pubmed publisher
    ..We investigated whether the polymorphisms in the complement receptor 1 (CR1) gene are associated with CVD in end-stage renal disease (ESRD) patients...
  67. Thathy V, Moulds J, Guyah B, Otieno W, Stoute J. Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya. Malar J. 2005;4:54 pubmed
    ..alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been ..
  68. Brubaker W, Crane A, Johansson J, Yen K, Garfinkel K, Mastroeni D, et al. Peripheral complement interactions with amyloid ? peptide: Erythrocyte clearance mechanisms. Alzheimers Dement. 2017;13:1397-1409 pubmed publisher
    ..peripheral clearance mechanism for pathogens, immune adherence, in which erythrocyte complement receptor 1 (CR1) plays a major role...
  69. Hinglais N, Kazatchkine M, Mandet C, Appay M, Bariety J. Human liver Kupffer cells express CR1, CR3, and CR4 complement receptor antigens. An immunohistochemical study. Lab Invest. 1989;61:509-14 pubmed
    ..b>CR1 and CR3 (alpha- and beta-chains) were found to be the predominant receptor antigens expressed by human KC...