CPT1C

Summary

Gene Symbol: CPT1C
Description: carnitine palmitoyltransferase 1C
Alias: CATL1, CPT1-B, CPT1P, CPTI-B, CPTIC, SPG73, carnitine O-palmitoyltransferase 1, brain isoform, carnitine O-palmitoyltransferase I, brain isoform, carnitine palmitoyltransferase I related C
Species: human
Products:     CPT1C

Top Publications

  1. Holloway G, Lally J, Nickerson J, Alkhateeb H, Snook L, Heigenhauser G, et al. Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle. J Physiol. 2007;582:393-405 pubmed
  2. Price N, van der Leij F, Jackson V, Corstorphine C, Thomson R, Sorensen A, et al. A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics. 2002;80:433-42 pubmed
    ..Thus this new CPT I related protein may be specialized for the metabolism of a distinct class of fatty acids involved in brain function. ..
  3. Bonnefont J, Djouadi F, Prip Buus C, Gobin S, Munnich A, Bastin J. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med. 2004;25:495-520 pubmed
    ..Prenatal diagnosis may be offered for pregnancies at a 1/4 risk of infantile/severe-type CPT2 deficiency. ..
  4. Wolfgang M, Lane M. The role of hypothalamic malonyl-CoA in energy homeostasis. J Biol Chem. 2006;281:37265-9 pubmed
    ..Recent evidence suggests that the brain-specific carnitine:palmitoyl-CoA transferase-1 (CPT1c) may be a regulated target of malonyl-CoA that relays the "malonyl-CoA signal" in hypothalamic neurons ..
  5. Sierra A, Gratacós E, Carrasco P, Clotet J, Ureña J, Serra D, et al. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem. 2008;283:6878-85 pubmed publisher
    b>CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria...
  6. Rodriguez Rodriguez R, Miralpeix C, Fosch A, Pozo M, Calderon Dominguez M, Perpinyà X, et al. CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity. Mol Metab. 2019;19:75-85 pubmed publisher
    Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis...
  7. Cardoso D, de Albuquerque L, Reimer C, Qanbari S, Erbe M, do Nascimento A, et al. Genome-wide scan reveals population stratification and footprints of recent selection in Nelore cattle. Genet Sel Evol. 2018;50:22 pubmed publisher
    ..genes included several genes with roles that are functionally related to growth metabolism, such as COL14A1, CPT1C, CRH, TBC1D1, and XKR4...
  8. Roa Mansergas X, Fadó R, Atari M, Mir J, Muley H, Serra D, et al. CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Sci Rep. 2018;8:6997 pubmed publisher
    ..Carnitine palmitoyltransferase 1 C (CPT1C) is a pseudoenzyme exclusively expressed in neurons and cancer cells...
  9. van der Hoek M, Madsen O, Keijer J, van der Leij F. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:909-918 pubmed publisher
    ..In the CPT1 family several duplications occurred during animal radiation, leading to the isoforms CPT1A, CPT1B and CPT1C. In addition, we found five CPT1-like genes in Caenorhabditis elegans that strongly group to the CPT1 family...

More Information

Publications41

  1. Wongwairot S, Kueakhai P, Changklungmoa N, Jaikua W, Sansri V, Meemon K, et al. Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica. Parasitol Res. 2015;114:133-40 pubmed publisher
    ..against rFgCatL1H reacted with the native protein in the gut of metacercariae and NEJ and also cross-reacted with CatL1 in 2- and 4-week-old juveniles and adult F. gigantica...
  2. Fadó R, Soto D, Miñano Molina A, Pozo M, Carrasco P, Yefimenko N, et al. Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus. J Biol Chem. 2015;290:25548-60 pubmed publisher
    ..Recent data suggest that one of the constituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform located in the endoplasmic reticulum of neurons...
  3. Chan J, Bittner S, Bittner A, Atwal S, Shen W, Inayathullah M, et al. Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. J Pharmacol Exp Ther. 2018;365:281-290 pubmed publisher
    ..the master regulator of fatty acid oxidation) and mRNA levels of carnitine palmitoyltransferases Cpt1c and Cpt2, key genes involved in fatty acid oxidation, compared with the ALIOS diet...
  4. Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, et al. Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. Cell Rep. 2018;22:706-721 pubmed publisher
    ..Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c)...
  5. Wang Y, Chen Y, Guan L, Zhang H, Huang Y, Johnson C, et al. Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming. Cell Death Differ. 2018;25:733-746 pubmed publisher
    ..Here we show that carnitine palmitoyltransferase 1C (CPT1C), an enzyme that catalyzes carnitinylation of fatty acids for transport into mitochondria for β-oxidation, plays ..
  6. Pozo M, Rodriguez Rodriguez R, Ramirez S, Seoane Collazo P, Lopez M, Serra D, et al. Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice. Endocrinology. 2017;158:2226-2238 pubmed publisher
    ..Based on global knockout (KO) models, CPT1C has demonstrated relevance in hippocampus-dependent spatial learning and in hypothalamic regulation of energy ..
  7. Wu Y, Sarkissyan M, Mcghee E, Lee S, Vadgama J. Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing. Breast Cancer Res Treat. 2015;151:529-39 pubmed publisher
    ..to augmented mitochondrial biogenesis and expression of fatty acid oxidation (FAO) genes including PPARα, MCAD, CPT1C, and ACO...
  8. Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier Pernet K, et al. AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability. Nat Commun. 2017;8:15910 pubmed publisher
    ..Central components of these ER AMPARs are the proteome constituents FRRS1l (C9orf4) and CPT1c that specifically and cooperatively bind to the pore-forming GluA1-4 proteins of AMPARs...
  9. Blumensatt M, Fahlbusch P, Hilgers R, Bekaert M, Herzfeld de Wiza D, Akhyari P, et al. Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial β-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR-208a. Basic Res Cardiol. 2017;112:2 pubmed
    ..shortening, and lowered palmitate-induced mitochondrial respiration and carnitine palmitoyltransferase 1c (CPT1c) expression in cardiomyocytes...
  10. Kueakhai P, Changklungmoa N, Chaichanasak P, Jaikua W, Itagaki T, Sobhon P. Vaccine potential of recombinant pro- and mature cathepsinL1 against fasciolosis gigantica in mice. Acta Trop. 2015;150:71-8 pubmed publisher
    In Fasciola gigantica cathepsin L1 (CatL1) is a family of predominant proteases that is expressed in caecal epithelial cells and secreted into the excretory-secretory products (ES)...
  11. Fang X, Zhao Z, Jiang P, Yu H, Xiao H, Yang R. Identification of the bovine HSL gene expression profiles and its association with fatty acid composition and fat deposition traits. Meat Sci. 2017;131:107-118 pubmed publisher
    ..HSL mRNA was highly expressed in the subcutaneous and visceral fat of cattle. CPT1B/CPT1C and other lipocatabolic genes were upregulated, and lipogenesis-related genes (FASN, LPL and ACOT12) were ..
  12. Kim W, Yun S, Yan C, Jeong P, Kim Y, Lee I, et al. Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls. Yonsei Med J. 2016;57:865-71 pubmed publisher
    ..The expression of eight genes involved in the carnitine-acylcarnitine metabolic pathway (CPT1A, CPT1B, CPT1C, CPT2, SLC25A20, and CRAT) or tryptophan metabolism (TPH1 and IDO1) was assessed by RT-PCR in our BCA cohort (n=..
  13. Yasrebi A, Hsieh A, Mamounis K, Krumm E, Yang J, Magby J, et al. Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol. Mol Cell Endocrinol. 2016;422:42-56 pubmed publisher
    ..In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC...
  14. Shinohara H, Kumazaki M, Minami Y, Ito Y, Sugito N, Kuranaga Y, et al. Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells. Cancer Lett. 2016;371:1-11 pubmed publisher
    ..compensatory fatty-acid oxidation (FAO) activation supported glucose-independent cell survival by up-regulating CPT1C, the rate-limiting FAO enzyme...
  15. Oosterman J, Belsham D. Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons. PLoS ONE. 2016;11:e0146969 pubmed publisher
    ..levels of Per2, Bmal1, Cryptochrome1 (Cry1), agouti-related peptide (AgRP), carnitine palmitoyltransferase 1C (Cpt1c), and O-linked N-acetylglucosamine transferase (Ogt) were measured...
  16. Broyl A, Corthals S, Jongen J, van der Holt B, Kuiper R, de Knegt Y, et al. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010;11:1057-65 pubmed publisher
  17. Schreurs M, Kuipers F, van der Leij F. Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev. 2010;11:380-8 pubmed publisher
    ..Recent developments are discussed, including a recently identified CPT1 isoform, i.e. CPT1C. This protein is highly expressed in the brain and may provide a target for new tools to prevent obesity.
  18. Cirillo A, Di Salle A, Petillo O, Melone M, Grimaldi G, Bellotti A, et al. High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism. Cancer Biol Ther. 2014;15:735-41 pubmed publisher
    ..We measured the mRNA levels of ZFP57, TRIM28, CPT1A, CPT1B, and CPT1C in a cohort of 80 patients divided in two groups: grade II and grade IV...
  19. van der Leij F, Huijkman N, Boomsma C, Kuipers J, Bartelds B. Genomics of the human carnitine acyltransferase genes. Mol Genet Metab. 2000;71:139-53 pubmed
    ..We will highlight the phylogenetics of the human carnitine acyltransferase genes in relation to the fungal genes YAT1 and CAT2, which encode cytosolic and mitochondrial/peroxisomal carnitine acetyltransferases, respectively. ..
  20. Rousso I, Mixon M, Chen B, Kim P. Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci U S A. 2000;97:13523-5 pubmed
    ..Our results strongly support the suggestion that HIV-1 buds from lipid rafts and point to a role for rafts as a viral assembly hub. ..
  21. Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T. Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res. 2006;66:6080-6 pubmed
    ..CGIs in putative promoter regions of 34 genes (ABHD9, BARHL1, CLIC5, CNNM1, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13,..
  22. Lohse I, Reilly P, Zaugg K. The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PLoS ONE. 2011;6:e21486 pubmed publisher
    ..Carnitine Palmitoyltransferase 1 C (CPT1C), the brain-specific member of the CPT 1 family, has previously been shown to be involved in regulating metabolism ..
  23. Borchert T, Hübscher D, Guessoum C, Lam T, Ghadri J, Schellinger I, et al. Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. J Am Coll Cardiol. 2017;70:975-991 pubmed publisher
    ..in catecholamine-treated TTS-iPSC-CMs, and were confirmed by differentially expressed lipid transporters CD36 and CPT1C. Furthermore, we uncovered genetic variants in different key regulators of cardiac function...
  24. Wang R, Cheng Y, Su D, Gong B, He X, Zhou X, et al. Cpt1c regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions. J Cancer. 2017;8:3675-3681 pubmed publisher
    ..In this study, we showed that expression of carnitine palmitoyltransferase 1C (Cpt1c), as a member of the gate-keeper enzymes , which transferring long-chain fatty acids into mitochondria to further ..
  25. Casals N, Zammit V, Herrero L, Fadó R, Rodríguez Rodríguez R, Serra D. Carnitine palmitoyltransferase 1C: From cognition to cancer. Prog Lipid Res. 2016;61:134-48 pubmed publisher
    ..Although CPT1C exhibits high sequence similarity to CPT1A and CPT1B, it is specifically expressed in neurons (a cell-type that ..
  26. Yan X, Zhang G, Bie F, Lv Y, Ma Y, Ma M, et al. Eugenol inhibits oxidative phosphorylation and fatty acid oxidation via downregulation of c-Myc/PGC-1?/ERR? signaling pathway in MCF10A-ras cells. Sci Rep. 2017;7:12920 pubmed publisher
    ..OXPHOS) complexs and the expression of fatty acid oxidation (FAO) proteins including PPAR?, MCAD and CPT1C by downregulating c-Myc/PGC-1?/ERR? pathway and decreasing oxidative stress in MCF10A-ras cells...
  27. Virmani A, Pinto L, Bauermann O, Zerelli S, Diedenhofen A, Binienda Z, et al. The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions. Mol Neurobiol. 2015;52:826-36 pubmed publisher
    ..Recently, a new, third isoform of CPT was described, CPT1c. This is a neuronal isoform and is prevalently localized in brain regions such as hypothalamus, amygdala, and ..
  28. Djouadi F, Aubey F, Schlemmer D, Bastin J. Peroxisome proliferator activated receptor delta (PPARdelta) agonist but not PPARalpha corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells. J Clin Endocrinol Metab. 2005;90:1791-7 pubmed
    ..Furthermore, these data also illustrate a selective control of beta-oxidation enzyme gene expression by PPARdelta, with no contribution of PPARalpha. ..
  29. Roomets E, Kivela T, Tyni T. Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in retina: insights of retinopathy in mitochondrial trifunctional protein defects. Invest Ophthalmol Vis Sci. 2008;49:1660-4 pubmed publisher
  30. Rinaldi C, Schmidt T, Situ A, Johnson J, Lee P, Chen K, et al. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. 2015;72:561-70 pubmed publisher
    ..Mutation in the neuronal isoform of carnitine palmitoyl-transferase (CPT1C) gene. We identified the nucleotide substitution c...
  31. Zaugg K, Yao Y, Reilly P, Kannan K, Kiarash R, Mason J, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011;25:1041-51 pubmed publisher
    ..Here we report that carnitine palmitoyltransferase 1C (CPT1C), a brain-specific metabolic enzyme, may participate in metabolic transformation...
  32. Chen Y, Wang Y, Huang Y, Zeng H, Hu B, Guan L, et al. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017;38:474-483 pubmed publisher
    Carnitine palmitoyltransferase 1C (CPT1C), an enzyme located in the outer mitochondria membrane, has a crucial role in fatty acid transport and oxidation...