CPT1B

Summary

Gene Symbol: CPT1B
Description: carnitine palmitoyltransferase 1B
Alias: CPT1-M, CPT1M, CPTI, CPTI-M, M-CPT1, MCCPT1, MCPT1, carnitine O-palmitoyltransferase 1, muscle isoform, carnitine O-palmitoyltransferase 1B, carnitine O-palmitoyltransferase I, mitochondrial muscle isoform, carnitine palmitoyltransferase 1B (muscle), carnitine palmitoyltransferase I-like protein
Species: human
Products:     CPT1B

Top Publications

  1. Zhu H, Shi J, de Vries Y, Arvidson D, Cregg J, Woldegiorgis G. Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I. Arch Biochem Biophys. 1997;347:53-61 pubmed
    ..This is the first report of the expression of a heart CPT-I in a system devoid of endogenous CPT activity and the functional characterization of a human heart M-CPT-I in the absence of the liver isoform and CPT-II. ..
  2. Dai J, Zhu H, Woldegiorgis G. Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. Biochem Biophys Res Commun. 2003;301:758-63 pubmed
    Muscle carnitine palmitoyltransferase I (M-CPTI) catalyzes the conversion of long-chain fatty acyl-CoAs to acylcarnitines in the presence of L-carnitine...
  3. Robitaille J, Houde A, Lemieux S, Perusse L, Gaudet D, Vohl M. Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians. J Mol Med (Berl). 2007;85:129-37 pubmed
    ..We identified 14 genetic variations in CPT1A and 26 in CPT1B. Nine variants within CPT1B and one variant within CPT1A were selected for further analyses based on the minor ..
  4. Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, et al. Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat Genet. 2008;40:1324-8 pubmed publisher
    ..rs5770917, a SNP located between CPT1B and CHKB, was associated with narcolepsy in Japanese (rs5770917[C], odds ratio (OR) = 1.79, combined P = 4...
  5. Miljkovic I, Yerges L, Li H, Gordon C, Goodpaster B, Kuller L, et al. Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men. Obesity (Silver Spring). 2009;17:1396-401 pubmed publisher
    ..Muscle carnitine palmitoyltransferase-1B (CPT1B) is a key enzyme in the regulation of skeletal muscle mitochondrial beta-oxidation of long-chain fatty acids, and ..
  6. Frias F, Rocha K, de Mendonça M, Murata G, Araujo H, De Sousa L, et al. Fenofibrate reverses changes induced by high-fat diet on metabolism in mice muscle and visceral adipocytes. J Cell Physiol. 2018;233:3515-3528 pubmed publisher
    ..to glucose and fatty acid metabolism in adipose tissue and soleus muscle, and proteins (phospho-AMPKα2, Pgc1α, Cpt1b), intramuscular lipid staining, and activities of fatty acid oxidation enzymes in skeletal muscle were ..
  7. Liu D, Deng K, Sampath W, Gu Z, Pan M, Zhang Y, et al. Responses of glucosensing system to glucose in Japanese flounder Paralichthys olivaceus fed diets with different carbohydrate content. Comp Biochem Physiol B Biochem Mol Biol. 2019;232:72-78 pubmed publisher
    ..In conclusion, glucosensing systems in Japanese flounder are responsive to dietary carbohydrate levels, especially the suitable dietary carbohydrate level, at which the glucose tolerance capacity of Japanese flounder was improved. ..
  8. Do Koo Y, Lee J, Lee S, Quaresma P, Bhat R, Haynes W, et al. SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle. Metabolism. 2019;: pubmed publisher
    ..of two FAO-associated genes: long-chain acyl-CoA synthetase 1(Acsl1) or carnitine palmitoyl transferase 1b (Cpt1b)...
  9. Yao C, Pang D, Lu C, Xu A, Huang P, Ouyang H, et al. Data Mining and Validation of AMPK Pathway as a Novel Candidate Role Affecting Intramuscular Fat Content in Pigs. Animals (Basel). 2019;9: pubmed publisher
    ..Ten key hub genes of this signaling pathway (AMPK, ADIPOR1, ADIPOR2, LKB1, CAMKKβ, CPT1A, CPT1B, PGC-1α, CD36, and ACC1) were differentially expressed between the Large White and Min pigs...

More Information

Publications110 found, 100 shown here

  1. Lu Z, He X, Ma B, Zhang L, Li J, Jiang Y, et al. The alleviative effects and related mechanisms of taurine supplementation on growth performance and carcass characteristics in broilers exposed to chronic heat stress. Poult Sci. 2019;98:878-886 pubmed publisher
    ..In conclusion, taurine supplementation can improve carcass characteristics of chronic heat-stressed broilers by facilitating lipolysis for energy, enhancing protein synthesis, and suppressing protein degradation of the breast muscles. ..
  2. Leduc Gaudet J, Reynaud O, Chabot F, Mercier J, Andrich D, St Pierre D, et al. The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiol Rep. 2018;6: pubmed publisher
    ..HFD did not alter ROS production and markers of mitochondrial content. The expression of CPT1b was significantly increased in SOL and EDL of HFD rats...
  3. Chriett S, Dąbek A, Wojtala M, Vidal H, Balcerczyk A, Pirola L. Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule. Sci Rep. 2019;9:742 pubmed publisher
    ..Butyrate had an extensive impact on gene transcription in rat myotubes, upregulating PGC1α, CPT1b, mitochondrial sirtuins (SIRT3-5), and the mitochondrial anti-oxidative genes SOD2 and catalase...
  4. Lu Y, Chen Y, Li R, Liu Q, Wang N, Zhang Y, et al. Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid. Biomed Pharmacother. 2018;107:1631-1640 pubmed publisher
    ..by promoting p-eNOS expression and enhancing NO release, decreasing lipid deposition (Oil-red O staining, CPT1b and ACC) and inflammation (IL-1β, TNFα, CD68 and p-JNK), alleviating oxidative and ER stress, and decreasing the ..
  5. Yang Y, Sadri H, Prehn C, Adamski J, Rehage J, Danicke S, et al. Acylcarnitine profiles in serum and muscle of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation. J Dairy Sci. 2019;102:754-767 pubmed publisher
    ..The mRNA abundance of carnitine palmitoyltransferase 1, muscle isoform (CPT1B) increased 2...
  6. Wei L, Yuan Z, Zhao M, Gu C, Han J, Fu L. Inhibition of Cannabinoid Receptor 1 Can Influence the Lipid Metabolism in Mice with Diet-Induced Obesity. Biochemistry (Mosc). 2018;83:1279-1287 pubmed publisher
    ..of CB1 expression in the D-SR group, the expression levels of CPT1A isoform (protein) in the liver and heart and CPT1B isoform (protein) in the SAT, VAT, liver and skeletal muscles were significantly increased (p < 0.05; D-SR vs...
  7. Suarez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, et al. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 2014;7:129-41 pubmed publisher
    ..The enhancement of the fatty-acid β-oxidation factors Cpt1b and Acox1 in eWAT was accompanied by an upregulation of de novo lipogenesis and reduced expression of the ..
  8. Ge X, Pan P, Jing J, Hu X, Chen L, Qiu X, et al. Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells. Reprod Biol Endocrinol. 2018;16:98 pubmed publisher
    ..On the other hand, the expression of CPT1B was not affected by RSG...
  9. Koo Y, Choi J, Kim M, Chae S, Ahn B, Kim M, et al. SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. Diabetes. 2015;64:2420-31 pubmed publisher
    ..to the promoters of the genes involved in fatty acid oxidation (FAO), such as carnitine-palmitoyl transferase-1 (CPT1b) and long-chain acyl-CoA synthetase 1 (ACSL1)...
  10. Wang D, Chen S, Liu M, Liu C. Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver. Chronobiol Int. 2015;32:615-26 pubmed publisher
    ..On P17, genes examined in the heart either showed anti-phase oscillations (Cpt1b, Pparα, Per2) or had greater oscillation amplitudes (Bmal1, Tnf-α, Il-6)...
  11. Creus A, Ferreira M, Oliva M, Lombardo Y. Mechanisms Involved in the Improvement of Lipotoxicity and Impaired Lipid Metabolism by Dietary α-Linolenic Acid Rich Salvia hispanica L (Salba) Seed in the Heart of Dyslipemic Insulin-Resistant Rats. J Clin Med. 2016;5: pubmed publisher
    ..This could reduce the influx of FAs, decreasing the elevated M-CPT1 activity and lipid storage and improving glucose oxidation in cardiac muscles of SRD-fed rats. ..
  12. Martins F, Bargut T, Aguila M, Mandarim de Lacerda C. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann Anat. 2017;210:44-51 pubmed publisher
    ..The findings suggest that the lack of substrate for thermogenesis and the local inflammation negatively regulated thermogenic signaling in the ob/ob mice. ..
  13. Ratner C, Madsen A, Kristensen L, Skov L, Pedersen K, Mortensen O, et al. Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity. Am J Physiol Regul Integr Comp Physiol. 2015;308:R973-82 pubmed publisher
  14. Le Bacquer O, Combe K, Montaurier C, Salles J, Giraudet C, Patrac V, et al. Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..acid transport (FATP, CD36), diacylglycerol/triacylglycerol biosynthesis (GPAT1, AGPAT1, DGAT1), and ?-oxidation (CPT1b, MCAD)...
  15. Yang Y, Jia H, Yu M, Zhou C, Sun L, Zhao Y, et al. Chinese patent medicine Xin-Ke-Shu inhibits Ca2+ overload and dysfunction of fatty acid ?-oxidation in rats with myocardial infarction induced by LAD ligation. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1079:85-94 pubmed publisher
    ..of the four key proteins, long-chain acyl-CoA synthetase 1 (ACSL1), carnitine palmitoyl transferase-1 (CPT1B), calcium/calmodulin-dependent kinase II (CaMKII), and phospholipase A2IIA (PLA2IIA)...
  16. Manor M, Cleveland B, Kenney P, Yao J, Leeds T. Differences in growth, fillet quality, and fatty acid metabolism-related gene expression between juvenile male and female rainbow trout. Fish Physiol Biochem. 2015;41:533-47 pubmed publisher
    ..Male liver also exhibited increased expression of β-oxidation genes cpt1b and ehhadh. These findings are indicative of increased mitochondrial β-oxidation in male liver...
  17. Verma M, Pandey S, Bhat I, Mukesh B, Anand J, Chandra V, et al. Impact of l-carnitine on lipid content and post thaw survivability of buffalo embryos produced in vitro. Cryobiology. 2018;82:99-105 pubmed publisher
    ..05) in treated than control groups. CPT1B, DGAT2 and DGAT1 mRNA expression was up regulated (p < 0...
  18. Legchenko E, Chouvarine P, Borchert P, Fernandez Gonzalez A, Snay E, Meier M, et al. PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. Sci Transl Med. 2018;10: pubmed publisher
    ..Consistently, pre-miR-197 and pre-miR-146b repressed genes that drive FAO (Cpt1b and Fabp4) in primary cardiomyocytes...
  19. Araki M, Nakagawa Y, Oishi A, Han S, Wang Y, Kumagai K, et al. The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..expression of genes involved in thermogenesis and fatty acid oxidation, including Ucp1, Cidea and Cpt1b in inguinal adipose tissue (iWAT) and the mitochondrial marker Elovl3 in brown adipose tissue (BAT)...
  20. Prasad V, Lorenz J, Lasko V, Nieman M, Jiang M, Gao X, et al. Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2014;77:53-63 pubmed publisher
    ..These results reveal a novel and specific role for PMCA4 in the Tm180 hypertrophic phenotype, with the "protective" effects of PMCA4 deficiency encompassing multiple determinants of HCM-related hypertrophy. ..
  21. Duckett S, Volpi Lagreca G, Alende M, Long N. Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep. Diabetes Metab Syndr Obes. 2014;7:553-63 pubmed publisher
    ..However, mRNA expression of glucose transporter type 4 (GLUT4) and carnitine palmitoyltransferase 1b (CPT1B) differed between tissues. In the subcutaneous adipose and liver, C16:1 infusion upregulated (P<0...
  22. Bétry C, Meugnier E, Pflieger M, Grenet G, Hercberg S, Galan P, et al. High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes Metab. 2019;45:152-159 pubmed publisher
    ..At the gene-expression level in skeletal muscle, carnitine palmitoyltransferase 1b (CPT1b) messenger RNA (mRNA) levels were around four times higher in the robust compared with frail counterparts...
  23. Palermo F, Cocci P, Mozzicafreddo M, Arukwe A, Angeletti M, Aretusi G, et al. Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes: revealed by computational modeling (docking) and transcriptional regulation of signaling pathways. Toxicol Res (Camb). 2016;5:471-481 pubmed publisher
    ..Collectively, our data indicate that TMCP can affect fatty acid synthesis/uptake and cholesterol metabolism through LXR? and PPARs, together with interactions between these transcription factors in seabream liver. ..
  24. Hamilton A, Ly J, Robinson J, Corder K, DeMoranville K, Schaeffer P, et al. Conserved transcriptional activity and ligand responsiveness of avian PPARs: Potential role in regulating lipid metabolism in mirgratory birds. Gen Comp Endocrinol. 2018;268:110-120 pubmed publisher
    ..3%), gcPPARγ (91.2%). We tested whether gcPPARs activated fatty acid (FA) utilization genes using Lpl and Cpt1b gene promoter-luciferase reporters in mammalian cell lines...
  25. Yuan H, Niu Y, Liu X, Fu L. Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Acta Physiol (Oxf). 2014;212:283-92 pubmed publisher
    Muscle-type carnitine palmitoyltransferase 1 (CPT1b) plays an important role in skeletal muscle mitochondrial fatty acid β-oxidation...
  26. Kao D, Lowes B, Gilbert E, Minobe W, Epperson L, Meyer L, et al. Therapeutic Molecular Phenotype of β-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy. Circ Cardiovasc Genet. 2015;8:270-83 pubmed publisher
    ..were decreases in NPPA and NPPB and increases in MYH6, ATP2A2, PLN, RYR2, ADRA1A, ADRB1, MYL3, PDFKM, PDHX, and CPT1B. All except PDHX involved increase in adult or decrease in fetal cardiac genes, but 100% were concordant with ..
  27. Krupková M, Liška F, Sedová L, Křenová D, Křen V, Seda O. Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model. Lipids Health Dis. 2014;13:172 pubmed publisher
    ..of metabolic and signalization pathways using differentially expressed genes we have identified a network with major nodes (including Sirt3, Il1b, Cpt1b and Pparg) likely to underlie the observed strain specific response to ATRA.
  28. van der Hoek M, Madsen O, Keijer J, van der Leij F. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:909-918 pubmed publisher
    ..In the CPT1 family several duplications occurred during animal radiation, leading to the isoforms CPT1A, CPT1B and CPT1C...
  29. Maimaitiyiming H, Norman H, Zhou Q, Wang S. CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity. Sci Rep. 2015;5:8846 pubmed publisher
    ..In addition, CD47 deficiency stimulated the expression of UCP1 and carnitine palmitoyltransferase 1b (CPT1b) levels in brown adipose tissue, leading to increased lipid utilization and heat production...
  30. Horiuchi M, Nakakuma M, Arimura E, Ushikai M, Yoshida G. [Experimental Approach to Analysis of the Relationship between Food Environments and Lifestyle-Related Diseases, Including Cardiac Hypertrophy, Fatty Liver, and Fatigue Symptoms]. Nihon Eiseigaku Zasshi. 2015;70:110-4 pubmed publisher
    ..The results will be applied to preventing and treating lifestyle-related diseases associated with fatty acid metabolism abnormality. ..
  31. Petrov P, Palou A, Bonet M, Ribot J. Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes From Retinoblastoma Haploinsufficient Mice. J Cell Physiol. 2016;231:1941-52 pubmed publisher
    ..glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b) but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2)...
  32. Schwarz K, Botigelli R, Del Collado M, Cavallari de Castro F, Fernandes H, Paschoal D, et al. Effects of fetal calf serum on cGMP pathway and oocyte lipid metabolism in vitro. Reprod Fertil Dev. 2017;29:1593-1601 pubmed publisher
    ..related to lipolysis, increasing relative expression of perilipin 2 (PLIN2) and carnitine palmitoyltransferase 1B (CPT1B) in cumulus cells...
  33. Wendel A, Purushotham A, Liu L, Belury M. Conjugated linoleic acid induces uncoupling protein 1 in white adipose tissue of ob/ob mice. Lipids. 2009;44:975-82 pubmed publisher
    ..in epididymal white adipose tissue (eWAT) , but significantly increased carnitine palmitoyltransferase-1b (CPT1b) and PPAR gamma coactivator-1alpha (PGC1alpha) expression...
  34. Bhattacharjee S, Das N, Mandala A, Mukhopadhyay S, Roy S. Fenofibrate Reverses Palmitate Induced Impairment in Glucose Uptake in Skeletal Muscle Cells by Preventing Cytosolic Ceramide Accumulation. Cell Physiol Biochem. 2015;37:1315-28 pubmed publisher
    ..Palmitate upregulated CPT1b expression in L6 myotubes, while CPT2 expression level remained unchanged...
  35. Ashmore T, Roberts L, Morash A, Kotwica A, Finnerty J, West J, et al. Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. BMC Biol. 2015;13:110 pubmed publisher
    ..In C2C12 myotubes, nitrate increased expression of the PPARα targets Cpt1b, Acadl, Hadh and Ucp3, and enhanced oxidative phosphorylation rates with palmitoyl-carnitine; however, these ..
  36. Casals N, Zammit V, Herrero L, Fadó R, Rodríguez Rodríguez R, Serra D. Carnitine palmitoyltransferase 1C: From cognition to cancer. Prog Lipid Res. 2016;61:134-48 pubmed publisher
    ..CPT1A and CPT1B were identified as the gate-keeper enzymes for the entry of long-chain fatty acids (as carnitine esters) into ..
  37. Decara J, Arrabal S, Beiroa D, Rivera P, Vargas A, Serrano A, et al. Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators. Biofactors. 2016;42:600-611 pubmed publisher
    ..expression of elements involved in lipogenesis (ChREBP, Acaca/ACC, Fasn/FAS, Scd1/SCD1, PPAR?/?), ?-oxidation (CPT1b), and thermogenesis (Cox4i1, Ucp1/UCP1) in eWAT and muscle, which suggest an increase in fatty-acid flux and ..
  38. Toledo F, Johannsen D, Covington J, Bajpeyi S, Goodpaster B, Conley K, et al. Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals. Diabetologia. 2018;61:466-475 pubmed publisher
    ..Overfeeding increased mRNA expression of certain genes coding for mitochondrial proteins (CS, OGDH, CPT1B, UCP3, ANT1)...
  39. Haffar T, Bérubé Simard F, Bousette N. Impaired fatty acid oxidation as a cause for lipotoxicity in cardiomyocytes. Biochem Biophys Res Commun. 2015;468:73-8 pubmed publisher
    ..We evaluated carnitine palmitoyltransferase (Cpt1b) expression by western blotting and mitochondrial membrane potential by quantitative and qualitative fluorescence ..
  40. Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, et al. The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-? agonist-induced amelioration of metabolic disorders in obese mice. J Biol Chem. 2017;292:9175-9190 pubmed publisher
    ..enhanced the expression of genes related to brown adipocyte functions, such as Ucp1, Pgc1a, and Cpt1b Fenofibrate increased energy expenditure and attenuated obesity, whole body insulin resistance, and adipocyte ..
  41. Kido K, Ito H, Yamamoto Y, Makita K, Uchida T. Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes. J Anesth. 2018;32:120-131 pubmed publisher
    ..PGC-1alpha and its downstream targets (NDUFS8 and SDHB, which are involved in the respiratory chain reaction; and CPT1B, which regulates beta-oxidation)...
  42. Fang X, Zhao Z, Jiang P, Yu H, Xiao H, Yang R. Identification of the bovine HSL gene expression profiles and its association with fatty acid composition and fat deposition traits. Meat Sci. 2017;131:107-118 pubmed publisher
    ..HSL mRNA was highly expressed in the subcutaneous and visceral fat of cattle. CPT1B/CPT1C and other lipocatabolic genes were upregulated, and lipogenesis-related genes (FASN, LPL and ACOT12) were ..
  43. Petrov P, Ribot J, López Mejía I, Fajas L, Palou A, Bonet M. Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells. J Cell Physiol. 2016;231:708-18 pubmed publisher
    ..for Rb (by 80-90%) had increased expression of genes related to fatty acid uptake and oxidation such as Cd36 and Cpt1b (by 61% and 42%, respectively), increased Mitofusin 2 protein content (∼2...
  44. Fleckenstein Elsen M, Dinnies D, Jelenik T, Roden M, Romacho T, Eckel J. Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes. Mol Nutr Food Res. 2016;60:2065-75 pubmed publisher
    ..In contrast, EPA increased expression of the brown adipocyte-related genes UCP1 and CPT1B, and improved mitochondrial function of adipocytes...
  45. Kim W, Yun S, Yan C, Jeong P, Kim Y, Lee I, et al. Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls. Yonsei Med J. 2016;57:865-71 pubmed publisher
    ..The expression of eight genes involved in the carnitine-acylcarnitine metabolic pathway (CPT1A, CPT1B, CPT1C, CPT2, SLC25A20, and CRAT) or tryptophan metabolism (TPH1 and IDO1) was assessed by RT-PCR in our BCA ..
  46. Zhang Y, Fang X, Dai M, Cao Q, Tan T, He W, et al. Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice. Obesity (Silver Spring). 2016;24:2533-2543 pubmed publisher
    ..CPT-1b represents a potential therapeutic target for the treatment of cardiac dysfunction related to metabolic diseases such as obesity and diabetes. ..
  47. Cesar A, Regitano L, Poleti M, Andrade S, Tizioto P, Oliveira P, et al. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics. 2016;17:961 pubmed
    ..OA DEGs identified important genes, canonical pathways and upstream regulators such as SCD, PLIN5, UCP3, CPT1, CPT1B, oxidative phosphorylation mitochondrial dysfunction, PPARGC1A, and FOXO1...
  48. Aguirre L, Milton Laskibar I, Hijona E, Bujanda L, Rimando A, Portillo M. Effects of pterostilbene in brown adipose tissue from obese rats. J Physiol Biochem. 2016;73:457-464 pubmed publisher
    ..proliferator-activated receptor γ co-activator 1 α (Pgc-1α), carnitine palmitoyl transferase 1b (Cpt1b), peroxisome proliferator-activated receptor α (Pparα), nuclear respiratory factor 1 (Nfr1), and ..
  49. Cheng Q, Zhao B, Huang Z, Su Y, Chen B, Yang S, et al. Epigenome-wide study for the offspring exposed to maternal HBV infection during pregnancy, a pilot study. Gene. 2018;658:76-85 pubmed publisher
    ..we identified 4 significantly differentially methylated CpG sites in the KLHL35 gene and additional CpGs for the CPT1B gene...
  50. McManus B, Korpela R, Speakman J, Cryan J, Cotter P, Nilaweera K. Bovine serum albumin as the dominant form of dietary protein reduces subcutaneous fat mass, plasma leptin and plasma corticosterone in high fat-fed C57/BL6J mice. Br J Nutr. 2015;114:654-62 pubmed publisher
    ..tissue (SAT), the HFD+BSA diet increased the mRNA levels of PPARα (PPARA), carnitine palmitoyltransferase 1b (CPT1b) and uncoupling protein 3 (UCP3), but reduced the mRNA level of leptin when compared with the HFD (P< 0·05)...
  51. Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, et al. Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther. 2018;9:47 pubmed publisher
    ..Seahorse was used to measure the level of oxidative phosphorylation. We found that overexpression of cpt1b enhanced reprogramming efficiency...
  52. Rozenfeld C, Butts I, Tomkiewicz J, Zambonino Infante J, Mazurais D. Abundance of specific mRNA transcripts impacts hatching success in European eel, Anguilla anguilla L. Comp Biochem Physiol A Mol Integr Physiol. 2016;191:59-65 pubmed publisher
    ..5, and 5HPF. However, at 30HPF the hatch group showed significantly higher abundance of cpt1a, cpt1b, β-tubulin, phb2, and pigf5 transcripts than the no hatch group...
  53. Mysore R, Liebisch G, Zhou Y, Olkkonen V, Nidhina Haridas P. Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition. Chem Phys Lipids. 2017;207:246-252 pubmed publisher
    ..Consistently, mRNAs encoding Angptl4 and Leptin, which facilitate lipolysis, as well as Cpt1a, Cpt1b, and Pgc-1? involved in FA oxidation, were elevated...
  54. Chen M, Chang J, Lin Y, Pan K, Ho W, Liu W, et al. Deciphering the gene expression profile of peroxisome proliferator-activated receptor signaling pathway in the left atria of patients with mitral regurgitation. J Transl Med. 2016;14:157 pubmed publisher
    ..The expressions of APOA1, ACADM, FABP3, ETFDH, ECH1, CPT1B, CPT2, SLC27A6, ACAA2, SMARCD3, SORBS1, EHHADH, SLC27A1, PPARGC1B, PPARA and CPT1A were significantly up-regulated,..
  55. Tzanavari T, Varela A, Theocharis S, Ninou E, Kapelouzou A, Cokkinos D, et al. Metformin protects against infection-induced myocardial dysfunction. Metabolism. 2016;65:1447-58 pubmed publisher
    ..LPS caused marked reduction of the cardiac metabolism-related genes tested, including Prkaa2, Cpt1b, Ppargc1a and Ppargc1b; reduction of fatty acid oxidation, as reflected by the regulation of Ppara, Acaca and ..
  56. Alsanea S, Gao M, Liu D. Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. AAPS J. 2017;19:797-805 pubmed publisher
    ..elevated the expression of fatty acid oxidation genes such as carnitine palmitoyltransferase 1a and 1b (Cpt1a and Cpt1b) and reduced expression of monocyte chemoattractant protein-1 (Mcp-1), de novo lipogenesis transcriptional factor ..
  57. Haffar T, Akoumi A, Bousette N. Lipotoxic Palmitate Impairs the Rate of β-Oxidation and Citric Acid Cycle Flux in Rat Neonatal Cardiomyocytes. Cell Physiol Biochem. 2016;40:969-981 pubmed
    ..We measured fatty acid oxidation, acetyl-CoA oxidation, and carnitine palmitoyl transferase (Cpt1b) activity...
  58. Arpón A, Milagro F, Razquin C, Corella D, Estruch R, Fito M, et al. Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids. Nutrients. 2017;10: pubmed publisher
    ..Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism...
  59. Lu Z, He X, Ma B, Zhang L, Li J, Jiang Y, et al. Chronic Heat Stress Impairs Meat Quality of Breast Muscle in Broilers through Affecting Redox Status and Energy Substances Metabolism. J Agric Food Chem. 2017;: pubmed publisher
    ..In conclusion, chronic heat stress impairs meat quality through malfunctioning mitochondria and affecting energy substances aerobic metabolism, resulting in increased glycolysis and intramuscular fat deposition...
  60. Yamazaki N, Shinohara Y, Kajimoto K, Shindo M, Terada H. Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I. J Biol Chem. 2000;275:31739-46 pubmed
    For characterization of the detailed gene structure of human muscle type carnitine palmitoyltransferase I (M-CPTI), we analyzed the 5'-upstream region of the M-CPTI transcripts...
  61. Matsuo T, Yamamoto A, Yamamoto T, Otsuki K, Yamazaki N, Kataoka M, et al. Replacement of C305 in heart/muscle-type isozyme of human carnitine palmitoyltransferase I with aspartic acid and other amino acids. Biochem Genet. 2010;48:193-201 pubmed publisher
    Liver- and heart/muscle-type isozymes of human carnitine palmitoyltransferase I (L- and M-CPTI, respectively) show a certain similarity in their amino acid sequences, and mutation studies on the conserved amino acids between these two ..
  62. Han F, Lin L, Li J, Aran A, Dong S, An P, et al. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med. 2012;13:269-72 pubmed publisher
    ..In contrast, CPT1B/CHKB polymorphisms have only been shown to be associated with narcolepsy in Japanese, with replication in a small ..
  63. Yu G, Lu Y, Gulick T. Expression of novel isoforms of carnitine palmitoyltransferase I (CPT-1) generated by alternative splicing of the CPT-ibeta gene. Biochem J. 1998;334 ( Pt 1):225-31 pubmed
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    ..The kinetic and chemical mechanisms are also discussed in relation to the different inhibitors under study for their potential to control diseases of lipid metabolism. ..
  65. Warfel J, Vandanmagsar B, Dubuisson O, Hodgeson S, Elks C, Ravussin E, et al. Examination of carnitine palmitoyltransferase 1 abundance in white adipose tissue: implications in obesity research. Am J Physiol Regul Integr Comp Physiol. 2017;312:R816-R820 pubmed publisher
    ..Recently, it was reported that decreased CPT1b mRNA in adipose tissue was a contributing factor for obesity in rats...
  66. Britton C, Mackey D, Esser V, Foster D, Burns D, Yarnall D, et al. Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). Genomics. 1997;40:209-11 pubmed
  67. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. DNA Res. 2001;8:1-9 pubmed
    ..For example, the sequence of a clone for KIAA1670 indicated that the CHKL and CPT1B genes were co-transcribed as a contiguous transcript without making both the protein-coding regions fused...
  68. Burgos Ramos E, Canelles S, Rodríguez A, Frago L, Gomez Ambrosi J, Chowen J, et al. The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling. Mol Cell Endocrinol. 2018;470:48-59 pubmed publisher
    ..These results suggest that leptin promotes an increase in muscle size associated with improved insulin signaling favored by lipid profile. ..
  69. Rousso I, Mixon M, Chen B, Kim P. Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci U S A. 2000;97:13523-5 pubmed
    ..Our results strongly support the suggestion that HIV-1 buds from lipid rafts and point to a role for rafts as a viral assembly hub. ..
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    ..We tested the hypothesis that polymorphisms of the genes involved in carnitine transport, OCTN2, CPT1A, CPT1B, and CPT2, might be associated with LVH. Haplotype-based association analysis in an observational study...
  71. Abraham R, Moskvina V, Sims R, Hollingworth P, Morgan A, Georgieva L, et al. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Med Genomics. 2008;1:44 pubmed publisher
    ..We provide evidence for LRAT as a novel candidate gene for LOAD. LRAT plays a prominent role in the Vitamin A cascade, a system that has been previously implicated in LOAD. ..
  72. Virmani A, Pinto L, Bauermann O, Zerelli S, Diedenhofen A, Binienda Z, et al. The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions. Mol Neurobiol. 2015;52:826-36 pubmed publisher
    ..CPT1 has two well-known isoforms, CPT1a and CPT1b. CPT1a is the hepatic isoform and CPT1b is typically muscular; both are normally utilized by the organism for ..
  73. Khan H, Alhomida A. Single nucleotide polymorphism in CPT1B and CPT2 genes and its association with blood carnitine levels in acute myocardial infarction patients. Gene. 2013;523:76-81 pubmed publisher
    ..We sequenced the coding regions of CPT1B and CPT2 genes to identify the single nucleotide polymorphism (SNP) in 23 AMI patients and 23 normal subjects...
  74. Zhang L, Li H, Hu X, Benedek D, Fullerton C, Forsten R, et al. Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD. Transl Psychiatry. 2015;5:e580 pubmed publisher
    ..Carnitine palmitoyltransferase 1B (CPT1B), an enzyme in the fatty acid metabolism and PPAR pathways, was significantly over-expressed in the amygdala (P &..
  75. Yamazaki N, Shinohara Y, Shima A, Yamanaka Y, Terada H. Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta. 1996;1307:157-61 pubmed
    With a cDNA probe encoding rat muscle type carnitine palmitoyltransferase I (CPTI), we isolated cDNA and genomic clones encoding the human homologue and deduced the primary structure of human muscle type CPTI...
  76. Vandanmagsar B, Warfel J, Wicks S, Ghosh S, Salbaum J, Burk D, et al. Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle. Cell Rep. 2016;15:1686-99 pubmed publisher
    ..a mouse model of impaired FAO by deleting carnitine palmitoyltransferase-1b specifically in skeletal muscle (Cpt1b(m-/-)). Cpt1b(m-/-) mice have increased glucose utilization and are resistant to diet-induced obesity...
  77. Lou P, Lucchinetti E, Scott K, Huang Y, Gandhi M, Hersberger M, et al. Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep. 2017;5: pubmed publisher
    ..fatty acid oxidation pathway was increased as a result of increased cellular uptake (CD36), mitochondrial uptake (CPT1B), as well as increased β-hydroxyacyl-CoA dehydrogenase and medium-chain acyl-CoA dehydrogenase ..
  78. Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H. Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I. FEBS Lett. 1997;409:401-6 pubmed
    We isolated a human muscle type of carnitine palmitoyltransferase I (CPTI-M) genomic clone and determined its entire nucleotide sequence...
  79. Landau M, Kenney K, Deuster P, Campbell W. Exertional rhabdomyolysis: a clinical review with a focus on genetic influences. J Clin Neuromuscul Dis. 2012;13:122-36 pubmed publisher
    ..The prognosis for ER is significantly better than that for other etiologies of rhabdomyolysis, but the risk of recurrence after an initial episode is unknown. Guidelines for management are provided. ..
  80. Maples J, Brault J, Witczak C, Park S, Hubal M, Weber T, et al. Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity. Am J Physiol Endocrinol Metab. 2015;309:E345-56 pubmed publisher
    ..to this metabolic inflexibility are not evident, a possible candidate is carnitine palmitoyltransferase-1B (CPT1B), which is a rate-limiting step in FAO...
  81. Baldán A, Relat J, Marrero P, Haro D. Functional interaction between peroxisome proliferator-activated receptors-alpha and Mef-2C on human carnitine palmitoyltransferase 1beta (CPT1beta) gene activation. Nucleic Acids Res. 2004;32:4742-9 pubmed
    ..Also for the synergistic activation of the CPT1beta gene promoter by MEF2C and PPARalpha-RXRalpha, a precise arrangement of its binding sites was essential. ..
  82. Yamazaki N, Matsuo T, Kurata M, Suzuki M, Fujiwaki T, Yamaguchi S, et al. Substitutions of three amino acids in human heart/muscle type carnitine palmitoyltransferase I caused by single nucleotide polymorphisms. Biochem Genet. 2008;46:54-63 pubmed
    Heart/muscle type carnitine palmitoyltransferase I (M-CPTI) catalyzes the rate-limiting step of mitochondrial long-chain fatty acid (LCFA) oxidation in muscle and adipose tissue...
  83. Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, et al. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). PLoS ONE. 2009;4:e5394 pubmed publisher
    SNP rs5770917 located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype were previously identified as susceptibility loci for narcolepsy with cataplexy...
  84. van der Leij F, Takens J, van der Veen A, Terpstra P, Kuipers J. Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta. 1997;1352:123-8 pubmed
    We isolated and sequenced cDNA and genomic DNA fragments of the human CPT1B gene, encoding muscle type camitine palmitoyltransferase I...
  85. Shingu Y, Yokota T, Takada S, Niwano H, Ooka T, Katoh H, et al. Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase. J Cardiol. 2018;71:65-70 pubmed publisher
    ..FABP3 gene expression in the atrium was reduced in patients with POAF. These findings suggest a potential link between altered fatty acid transport in the atrium and increased AF onset after cardiac surgery. ..
  86. Yu G, Lu Y, Gulick T. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate. J Biol Chem. 1998;273:32901-9 pubmed
    ..The constitutive repressor chicken ovalbumin upstream promoter transcription factor competitively binds at the FARE and modulates fatty acid induction of the promoters. ..
  87. van der Leij F, Huijkman N, Boomsma C, Kuipers J, Bartelds B. Genomics of the human carnitine acyltransferase genes. Mol Genet Metab. 2000;71:139-53 pubmed
    ..active forms of related carnitine acyltransferases: CPT1A for liver-type carnitine palmitoyltransferase I, CPT1B for muscle-type carnitine palmitoyltransferase I, CPT2 for carnitine palmitoyltransferase II, CROT for carnitine ..
  88. Gómez Gómez E, Ríos Martínez M, Castro Rodríguez E, Del Toro Equihua M, Ramirez Flores M, Delgado Enciso I, et al. Carnitine palmitoyltransferase 1B 531K allele carriers sustain a higher respiratory quotient after aerobic exercise, but ?3-adrenoceptor 64R allele does not affect lipolysis: a human model. PLoS ONE. 2014;9:e96791 pubmed publisher
    Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism...
  89. Liu H, Zheng G, Treber M, Dai J, Woldegiorgis G. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. J Biol Chem. 2005;280:4524-31 pubmed
    ..To determine the role of the 15 cysteine residues in the heart/skeletal muscle isoform of CPTI (M-CPTI) on catalytic activity and malonyl-CoA sensitivity, we constructed a 6-residue N-terminal, a 9-residue C-..
  90. Chen S, Chao P. Prenatal PPAR? activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood. PLoS ONE. 2017;12:e0187507 pubmed publisher
    ..day 84 (P84), CF-offspring had significantly higher expression of thermogenic genes (Ucp1, Cidea, Ppara Ppargc1a, Cpt1b) and UCP1 protein levels in response to HFD in inguinal fat, but not in retroperitoneal (combined with perirenal) ..
  91. Warfel J, Vandanmagsar B, Wicks S, Zhang J, Noland R, Mynatt R. A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle. PLoS ONE. 2017;12:e0188850 pubmed publisher
    ..The favorable metabolic phenotype of Cpt1bm-/- mice therefore remains consistent regardless of diet; and a combination of a low fat diet and pharmacological inhibition of CPT1b may offer remedies to reduce blood glucose.
  92. Auinger A, Rubin D, Sabandal M, Helwig U, Ruther A, Schreiber S, et al. A common haplotype of carnitine palmitoyltransferase 1b is associated with the metabolic syndrome. Br J Nutr. 2013;109:810-5 pubmed publisher
    ..We performed an analysis including three coding SNP in the muscle isoform of the CPT1b gene (rs3213445, rs2269383 and rs470117) and one coding SNP in the CPT2 gene (rs1799821) to find associations with ..