CPSF4

Summary

Gene Symbol: CPSF4
Description: cleavage and polyadenylation specific factor 4
Alias: CPSF30, NAR, NEB-1, NEB1, cleavage and polyadenylation specificity factor subunit 4, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, cleavage and polyadenylation specific factor 4, 30kDa, cleavage and polyadenylation specificity factor 30 kDa subunit, no arches homolog, no arches-like zinc finger protein
Species: human
Products:     CPSF4

Top Publications

  1. de Vries H, Rüegsegger U, Hubner W, Friedlein A, Langen H, Keller W. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. EMBO J. 2000;19:5895-904 pubmed
    ..hClp1 interacts with CF I(m) and the cleavage and polyadenylation specificity factor CPSF, suggesting that it bridges these two 3' end processing factors within the cleavage complex. ..
  2. McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, et al. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature. 1997;385:357-61 pubmed
  3. Nemeroff M, Barabino S, Li Y, Keller W, Krug R. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell. 1998;1:991-1000 pubmed
    ..Via this novel regulation of pre-mRNA 3' end processing, the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. ..
  4. Barabino S, Hubner W, Jenny A, Minvielle Sebastia L, Keller W. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Genes Dev. 1997;11:1703-16 pubmed
    ..Efficient polyadenylation activity can be restored by the addition of purified polyadenylation factor I (PF I). We demonstrate that Yth1p is a component of PF I that interacts in vivo and in vitro with Fip1p, a known PF I subunit. ..
  5. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J. 2004;23:616-26 pubmed
    ..These results show that hFip1 significantly contributes to CPSF-mediated stimulation of PAP activity. ..
  6. Rozenblatt Rosen O, Nagaike T, FRANCIS J, Kaneko S, Glatt K, Hughes C, et al. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proc Natl Acad Sci U S A. 2009;106:755-60 pubmed publisher
    ..Our results suggest that Cdc73 facilitates association of 3' mRNA processing factors with actively-transcribed chromatin and support the importance of links between tumor suppression and mRNA maturation. ..
  7. Liu M, Xu R, Merrill C, Hong L, Von Lanken C, Hunt A, et al. Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis. PLoS ONE. 2014;9:e115779 pubmed publisher
    ..Moreover, 19 genes that are linked with calmodulin-dependent CPSF30 functions, were identified through genome-wide expression analysis...
  8. Ryl A, Rotter I, Slojewski M, Dolegowska B, Grabowska M, Baranowska Bosiacka I, et al. Hormone concentration, metabolic disorders and immunoexpression of androgen and estrogen-alpha receptors in men with benign prostatic hyperplasia and testosterone deficiency syndrome. Folia Histochem Cytobiol. 2015;53:227-35 pubmed publisher
    ..Quantitative analysis revealed 35.8% AR-positive colum-nar epithelial cells and 24.3% AR-positive stromal cells in prostates of BPH patients with TDS and 30.5% and 23...
  9. Tomljenovic D, Baudoin T, Megla Z, Geber G, Scadding G, Kalogjera L. Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis. Med Hypotheses. 2018;116:114-118 pubmed publisher
    Epidemiological studies show female predominance in the prevalence of non- allergic rhinitis (NAR) and local allergic rhinitis (LAR)...

More Information

Publications129 found, 100 shown here

  1. DeDiego M, Nogales A, Lambert Emo K, Martinez Sobrido L, Topham D. NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses. J Virol. 2016;90:9693-9711 pubmed publisher
    ..of host protein synthesis by decreasing its interaction with cleavage and polyadenylation specificity factor 30 (CPSF30), leading to increased innate immune responses after viral infection...
  2. Nogales A, Martinez Sobrido L, Topham D, DeDiego M. NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses. J Virol. 2017;91: pubmed publisher
    ..because these mutations decreased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF30)...
  3. Nogales A, Chauché C, DeDiego M, Topham D, Parrish C, Murcia P, et al. The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression. J Virol. 2017;91: pubmed publisher
    ..K186E) that resulted in NS1 binding to the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), a cellular protein involved in pre-mRNA processing...
  4. Sánchez A, Guerrero Juarez C, Ramirez J, Newcomb L. Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation. Virol J. 2014;11:155 pubmed publisher
    ..NS1 mutant analysis confirms NS1-RNA binding is not required for the translational enhancement and reveals the NS1-CPSF30 interaction surface is essential...
  5. Borrero de Acuña J, Rohde M, Wissing J, Jänsch L, Schobert M, Molinari G, et al. Protein Network of the Pseudomonas aeruginosa Denitrification Apparatus. J Bacteriol. 2016;198:1401-13 pubmed publisher
    ..the denitrification apparatus of the pathogenic bacterium Pseudomonas aeruginosa During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)â†..
  6. Zhang L, Wang J, Muñoz Moreno R, Kim M, Sakthivel R, Mo W, et al. Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting. J Virol. 2018;92: pubmed publisher
    ..binding domain and is independent of the NS1 interaction with the cleavage and polyadenylation specificity factor CPSF30. NS1 has been previously shown to abrogate RIG-I-mediated antiviral immunity by inhibiting its protein function...
  7. Hufnagel D, Evans M, Greene S, Pinkner J, Hultgren S, Chapman M. The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli. J Bacteriol. 2016;198:3329-3334 pubmed
    ..Constantinidou, J. L. Hobman, and S. D. Minchin, Nucleic Acids Res 32:5874-5893, 2004, https://dx.doi.org/10.1093/nar/gkh908). Glucose inhibits E...
  8. Ashraf S, Radhi M, Gowler P, Burston J, Gandhi R, Thorn G, et al. The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Sci Rep. 2019;9:4696 pubmed publisher
    ..high or low grade inflammation and non-arthritic post-mortem controls were analysed for the polyadenylation factor CPSF4 and inflammatory markers...
  9. Sawers R, Falke D, Fischer M. Oxygen and Nitrate Respiration in Streptomyces coelicolor A3(2). Adv Microb Physiol. 2016;68:1-40 pubmed publisher
    ..remains Streptomyces coelicolor A3(2), and it synthesises three nonredundant respiratory nitrate reductases (Nar)...
  10. Sun Y, De Vos P, Heylen K. Nitrous oxide emission by the non-denitrifying, nitrate ammonifier Bacillus licheniformis. BMC Genomics. 2016;17:68 pubmed publisher
    ..licheniformis demonstrated similar gene inventories, with specific duplications of the nar operon, narK and hmp genes as well as NarG phylogeny supporting the evolutionary separation of previously described ..
  11. Chauche C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza A, Gu Q, et al. Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1. J Virol. 2018;92: pubmed publisher
    ..proteins of early EIVs block general gene expression by binding to cellular polyadenylation-specific factor 30 (CPSF30), NS1 proteins from more evolved EIVs specifically block the induction of IFN-stimulated genes by interfering with ..
  12. Gathara D, Opiyo N, Wagai J, Ntoburi S, Ayieko P, Opondo C, et al. Quality of hospital care for sick newborns and severely malnourished children in Kenya: a two-year descriptive study in 8 hospitals. BMC Health Serv Res. 2011;11:307 pubmed publisher
    ..Introducing a standard newborn admission record (NAR) form was associated with an increase in median assessment (IQR) score to 25/28 (22-27) from 2/28 (1-4) at baseline...
  13. Hsu E, Pennella M, Zemke N, Eng C, Berk A. Adenovirus E1A Activation Domain Regulates H3 Acetylation Affecting Varied Steps in Transcription at Different Viral Promoters. J Virol. 2018;92: pubmed publisher
    ..S. Turnell, R. J. A. Grand, J. S. Mymryk, Nucleic Acids Res 37:1095-1106, 2009, https://doi.org/10.1093/nar/gkn1057), and that the resulting acetylation of H3K18/27 affects varied steps in transcription at different viral ..
  14. Singh U, Wangia Anderson V, Bernstein J. Chronic Rhinitis Is a High-Risk Comorbidity for 30-Day Hospital Readmission of Patients with Asthma and Chronic Obstructive Pulmonary Disease. J Allergy Clin Immunol Pract. 2019;7:279-285.e6 pubmed publisher
    ..Relevant comorbidities, including comorbid allergic rhinitis (AR) or nonallergic rhinitis (NAR), in such patients were identified using ICD-10-CM codes...
  15. Karami K, Mehri Lighvan Z, Farrokhpour H, Dehdashti Jahromi M, Momtazi Borojeni A. Synthesis and spectroscopic characterization study of new palladium complexes containing bioactive O,O-chelated ligands: evaluation of the DNA/protein BSA interaction, in vitro antitumoural activity and molecular docking. J Biomol Struct Dyn. 2017;:1-17 pubmed publisher
    ..Qu)] (2) and [Pd{(C,N)-C6H4CH2NH(Et) (Nar)] (3) (Qu = Quercetin, Nar = Naringin) mononuclear palladium (II) complexes have been synthesized and ..
  16. Vilaseca I, Lehrer Coriat E, Torres M, Aguilar F, Almendros I, Martínez Vidal B, et al. Early effects of continuous positive airway pressure in a rodent model of allergic rhinitis. Sleep Med. 2016;27-28:25-27 pubmed publisher
    ..The allergic (AR) and non-allergic (NAR) rats were then randomized to nasal CPAP at 10 cm H2O for five hours or to sham CPAP...
  17. Lin Y, Sekedat M, Cornell W, Silva G, Okegbe C, Price Whelan A, et al. Phenazines Regulate Nap-Dependent Denitrification in Pseudomonas aeruginosa Biofilms. J Bacteriol. 2018;200: pubmed publisher
    ..growth, with nitrate as the terminal electron acceptor, which depends on the membrane-associated nitrate reductase Nar. We identified the sequences in the promoter regions of the nap and nir operons that are required for ..
  18. Bernstein J, Singh U. Neural Abnormalities in Nonallergic Rhinitis. Curr Allergy Asthma Rep. 2015;15:18 pubmed publisher
    ..Other agents effective in treating nonallergic rhinitis (NAR) such as azelastine have been demonstrated to exhibit TRPV1 channel activity through the modulation of Ca(2+) ..
  19. Zhang Y, Cao P, Lu F, Yan X, Jiang B, Cheng J, et al. Generation of Monoclonal Antibodies Against Natural Products. J Vis Exp. 2019;: pubmed publisher
    ..The final mAbs were further characterized by icELISA and then utilized in an ELISA-based application for the rapid and convenient detection of the example hapten (naringin (NAR)) in natural products.
  20. Clark A, Nogales A, Martinez Sobrido L, Topham D, DeDiego M. Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses. J Virol. 2017;91: pubmed publisher
    ..NS1 to inhibit general host gene expression, mainly by their ability to restore binding to the cellular factor CPSF30. This is the first report describing the ability of the pH1N1 NS1 protein to naturally acquire mutations that ..
  21. Cheng Y, Pedroso A, Porwollik S, McClelland M, Lee M, Kwan T, et al. rpoS-Regulated core genes involved in the competitive fitness of Salmonella enterica Serovar Kentucky in the intestines of chickens. Appl Environ Microbiol. 2015;81:502-14 pubmed publisher
    ..Kentucky. The contributions of four of these operons (mgl, prp, nar, and csg) to Salmonella colonization in chickens were assessed. Deletion of mgl and csg reduced S...
  22. Kleinpeter A, Jureka A, Falahat S, Green T, Petit C. Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds. J Biol Chem. 2018;293:14659-14668 pubmed publisher
    ..pocket known to facilitate binding to the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), suggesting that the two compounds likely attenuate influenza replication by inhibiting the NS1ED-..
  23. Mustafi M, Weisshaar J. Simultaneous Binding of Multiple EF-Tu Copies to Translating Ribosomes in Live Escherichia coli. MBio. 2018;9: pubmed publisher
    ..Smilansky, B. S. Cooperman, and A. N. Kapanidis, Nucleic Acids Res 45:926-937, 2016, https://doi.org/10.1093/nar/gkw787) of tRNA diffusion in E...
  24. Yang S, Zhou L, Lu Z, Ma B, Ji Q, Wang Y. Systematic review with meta-analysis of intraoperative neuromonitoring during thyroidectomy. Int J Surg. 2017;39:104-113 pubmed publisher
    ..Odds ratio (OR) was calculated by random effects model. Overall, 9203 patients and 17,203 nerves at risk (NAR) were included. Incidence of overall, transient, and persistent RLNP in IONM group were, respectively, 3.15%, 1...
  25. Badran H, Hussein A, Salah M, Lotfi W. Identification and Prevalence of Allergic, Nonallergic, and Local Allergic Rhinitis Patients in Western Area, Saudi Arabia. Ann Otol Rhinol Laryngol. 2016;125:634-43 pubmed publisher
    ..test (NPT) for the determination of local allergic rhinitis (LAR) in patients with nonallergic rhinitis (NAR). This multi-center study included 1230 patients with clinical manifestations for ?2 years...
  26. Shao H, Yang Y, Qi A, Hong P, Zhu G, Cao X, et al. Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents. Neurochem Res. 2017;42:360-374 pubmed publisher
    ..6 currents (persistent (INaP) and resurgent (INaR) currents), which were reported to play a critical role in the generation of bursting spikes...
  27. Kramer K, Thye T, Treszl A, Peine S, Koch M, Sterneck M, et al. Polymorphism in NFKBIA gene is associated with recurrent acute rejections in liver transplant recipients. Tissue Antigens. 2014;84:370-7 pubmed publisher
    ..A total of 199 liver transplant recipients was analyzed, 100 without (NAR) and 99 with early acute rejection (AR)...
  28. M Kaibi F, Steyn N, Ochola S, Du Plessis L. Effects of agricultural biodiversity and seasonal rain on dietary adequacy and household food security in rural areas of Kenya. BMC Public Health. 2015;15:422 pubmed publisher
    ..A nutrient adequacy ratio (NAR) was calculated for each nutrient as the percent of the nutrient meeting the recommended nutrient intake (RNI) for ..
  29. Munshi S, Tran T, Vo T, Tabassum S, Sultana N, Nguyen T, et al. Molecular characterization of hepatitis B virus in Bangladesh reveals a highly recombinant population. PLoS ONE. 2017;12:e0188944 pubmed publisher
    ..Genotype, subgenotype, virulence, nucleos(t)ide analogue (NA) resistance (NAr) mutations, and the prevalence of recombinant isolates were determined...
  30. Clerici M, Faini M, Aebersold R, Jinek M. Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex. elife. 2017;6: pubmed publisher
    ..A core CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 is sufficient for AAUAAA motif recognition, yet the molecular interactions underpinning its assembly and ..
  31. Greuter D, Loy A, Horn M, Rattei T. probeBase--an online resource for rRNA-targeted oligonucleotide probes and primers: new features 2016. Nucleic Acids Res. 2016;44:D586-9 pubmed publisher
    ..Here we present a major update of probeBase, which was last featured in the NAR Database Issue 2007...
  32. Tsybikov N, Egorova E, Kuznik B, Fefelova E, Magen E. Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. Allergy Asthma Proc. 2016;37:35-42 pubmed publisher
    ..divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS)...
  33. Soliman M, Eldyasti A. Development of partial nitrification as a first step of nitrite shunt process in a Sequential Batch Reactor (SBR) using Ammonium Oxidizing Bacteria (AOB) controlled by mixing regime. Bioresour Technol. 2016;221:85-95 pubmed publisher
    ..Batch Reactor (SBR) in order to achieve a stable ammonia removal efficiency (ARE) and nitrite accumulation rate (NAR) at a high nitrogen loading rate (NLR). The new controlled SBR system has been successfully running at NLR up to 1...
  34. Hellevik A, Nordsletten L, Johnsen M, Fenstad A, Furnes O, Storheim K, et al. Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register). Osteoarthritis Cartilage. 2017;25:1654-1662 pubmed publisher
    ..and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis...
  35. Boix F, Millán O, San Segundo D, Mancebo E, Rimola A, Fábrega E, et al. High expression of CD38, CD69, CD95 and CD154 biomarkers in cultured peripheral T lymphocytes correlates with an increased risk of acute rejection in liver allograft recipients. Immunobiology. 2016;221:595-603 pubmed publisher
    ..post-transplantation surface antigens levels displayed significant differences between AR and non acute rejection (NAR) groups, and also this differential expression was used to construct a risk predictive model based on a composite ..
  36. Demirtürk M, Gelincik A, Ulusan M, Ertek B, Büyüköztürk S, Çolakoğlu B. The importance of mold sensitivity in nonallergic rhinitis patients. Int Forum Allergy Rhinol. 2016;6:716-21 pubmed publisher
    ..provocation test (NAPT) have been demonstrated in some patients initially diagnosed as nonallergic rhinitis (NAR) or idiopathic rhinitis (IR)...
  37. Kuo R, Li L, Lin S, Li Z, Chen G, Chang C, et al. Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation. J Virol. 2016;90:4696-4705 pubmed publisher
    ..response through various mechanisms, including blocking cellular mRNA maturation by binding the cellular CPSF30 3' end processing factor and/or suppressing the activation of interferon regulatory factor 3 (IRF3)...
  38. Lim J, Pang Q, Alexander R. One year negative appendicectomy rates at a district general hospital: A Retrospective Cohort Study. Int J Surg. 2016;31:1-4 pubmed publisher
    There is no defined 'acceptable' Negative Appendicectomy Rate (NAR) in the UK...
  39. Noguchi T, Nishida Y, Takizawa K, Cui Y, Tsutsumi K, Hamada T, et al. Accurate quantitation for in vitro refolding of single domain antibody fragments expressed as inclusion bodies by referring the concomitant expression of a soluble form in the periplasms of Escherichia coli. J Immunol Methods. 2017;442:1-11 pubmed publisher
    Single domain antibody fragments from two species, a camel VHH (PM1) and a shark VNAR (A6), were derived from inclusion bodies of E...
  40. Liu X, Zhang B, Zhao W, Wang L, Xie D, Huo W, et al. Comparative effects of sulfuric and nitric acid rain on litter decomposition and soil microbial community in subtropical plantation of Yangtze River Delta region. Sci Total Environ. 2017;601-602:669-678 pubmed publisher
    ..The relative composition of acid rain is changing gradually from sulfuric acid rain (SAR) to nitric acid rain (NAR) with the rapidly growing amount of nitrogen deposition...
  41. Axelsen K, Nafei H, Jakobsen S, Gandrup P, Knudsen J. [Case managers experience improved trajectories for cancer patients after implementation of the case manager function]. Ugeskr Laeger. 2015;177:1175-7 pubmed
    ..The responsibility has in general been nar­rowed to department level...
  42. Wu W, An S, Guo J, Guan P, Ren Y, Xia L, et al. [Application of nonlinear autoregressive neural network in predicting incidence tendency of hemorrhagic fever with renal syndrome]. Zhonghua Liu Xing Bing Xue Za Zhi. 2015;36:1394-6 pubmed
    ..Monthly reported case series of HFRS in China from 2004 to 2013 were used to build both ARIMA and NAR neural network models, in order to predict the monthly incidence of HFRS in China in 2014...
  43. Brauckhoff K, Aas T, Biermann M, Husby P. EMG changes during continuous intraoperative neuromonitoring with sustained recurrent laryngeal nerve traction in a porcine model. Langenbecks Arch Surg. 2017;402:675-681 pubmed publisher
    ..In 29 nerves at risk (NAR), BL amplitude and latency values were 1098 ± 418 (586-2255) μV (mean ± SD (..
  44. Zhu Z, Xie Y, Guan W, Gao Y, Xia S, Huang R, et al. Effects of leukotriene D4 and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients. Clin Respir J. 2016;: pubmed publisher
    ..Nasal airway resistance (NAR) increased significantly after both LTD4 and histamine nasal challenge in AR patients (P?<?.05)...
  45. Sattar M, Hadgraft J, Lane M. Preparation, characterization and buccal permeation of naratriptan. Int J Pharm. 2015;493:146-51 pubmed publisher
    Naratriptan (NAR) is currently used for the management of migraine as the hydrochloride salt (NAR.HCl) and is administered as an oral tablet...
  46. Chinzei N, Hiranaka T, Niikura T, Fujishiro T, Hayashi S, Kanzaki N, et al. Accurate and Easy Measurement of Sliding Distance of Intramedullary Nail in Trochanteric Fracture. Clin Orthop Surg. 2015;7:152-7 pubmed publisher
    ..five measurements of the sliding distance of the HFD in each of the flowing four methods: nail axis reference (NAR), modified NAR, inner edge reference, and nail tip reference...
  47. Khalimon A, Farha P, Nikonov G. Imido-hydrido complexes of Mo(IV): catalysis and mechanistic aspects of hydroboration reactions. Dalton Trans. 2015;44:18945-56 pubmed publisher
    ..across the Mo-H bond to give (ArN)Mo(Cl)(N[double bond, length as m-dash]CHR)(PMe3)2; whereas for complex 2 stoichiometric reactions suggest initial addition of HBCat to form the agostic complex Mo(H)2(PMe3)3(η(3)-NAr-HBcat) (16).
  48. Mercanoglu G, Safran N, Ahishali B B, Uzun H, Yalcin A, Mercanoglu F. Nitric oxide mediated effects of nebivolol in myocardial infarction: the source of nitric oxide. Eur Rev Med Pharmacol Sci. 2015;19:4872-89 pubmed
    ..divided into four groups: sham operated (sham-control), MI-induced (MI-control), immediate nebivolol loaded (MI-neb1), orally nebivolol treated (MI-neb2). MI was induced by the ligation of the LAD. Loading dose of nebivolol (0...
  49. Lee K, Yu J, Shim D, Choi H, Jang M, Kim K, et al. Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis. PLoS ONE. 2016;11:e0156979 pubmed publisher
    ..To compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two ..
  50. Liu X, Zhang D, Zhang G, Zhao L, Zhou L, Fu Y, et al. Laryngeal nerve morbidity in 1.273 central node dissections for thyroid cancer. Surg Oncol. 2018;27:A21-A25 pubmed publisher
    ..CND with intraoperative neural monitoring was outlined in 1.273 nerves at risk (NAR). RLN lesions were stratified according to: timing (during thyroidectomy versus CND), segmental vs...
  51. Mamedov A, Bertsova Y, Anashkin V, Mamedov M, Baykov A, Bogachev A. Identification of the key determinant of the transport promiscuity in Na+-translocating rhodopsins. Biochem Biophys Res Commun. 2018;499:600-604 pubmed publisher
    ..A Cys253Ser variant of the strictly specific Dokdonia sp. PRO95 Na+-rhodopsin (NaR) was indeed found to transport both Na+ and H+ in a light-dependent manner when expressed in ..
  52. Kutlug S, Gunbey E, Sogut A, Celiksoy M, Kardas S, Yıldırım U, et al. Evaluation of olfactory function in children with allergic rhinitis and nonallergic rhinitis. Int J Pediatr Otorhinolaryngol. 2016;86:172-6 pubmed publisher
    ..In the presence of rhinitis symptoms without infection or an allergic reaction in the nose, non-allergic rhinitis (NAR) is considered. Adults with these diseases have increased frequency of olfactory dysfunction...
  53. Kumar R, Abraham A. PVP- coated naringenin nanoparticles for biomedical applications - In vivo toxicological evaluations. Chem Biol Interact. 2016;257:110-8 pubmed publisher
    Naringenin (NAR) is one of the naturally occurring flavonoids found in citrus fruits and exerts a wide variety of pharmacological activities...
  54. Yan N, Wen L, Peng R, Li H, Liu H, Peng H, et al. Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy. J Diabetes Res. 2016;2016:8738760 pubmed publisher
    ..area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks...
  55. Manuyakorn W, Klangkalya N, Kamchaisatian W, Benjaponpita S, Sasisakulporn C, Jotikasthira W. Efficacy of Nasal Cellulose Powder in the Symptomatic Treatment of Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial. Allergy Asthma Immunol Res. 2017;9:446-452 pubmed publisher
    ..scores (DSS), daily medication scores (DMS), the peak nasal inspiratory flows (PNIF), nasal airway resistance (NAR), as well as the maximum tolerated dose of NPT and eosinophil counts in nasal scraping, were evaluated...
  56. Orkin B, Poirier J, Kowal Vern A, Chan E, Ohara K, Mendoza B. Effect of protected research time on ABSITE scores during general surgery residency. Am J Surg. 2018;215:322-325 pubmed publisher
    ..RR were compared to N-RR. Additional analysis of At Risk (AR) v Not At Risk residents (NAR) (<or >35th percentile as PGY1-2) was also performed. Cohort - 147 residents (34 RR and 113 N-RR)...
  57. Wasilewska K, Zasiadczyk Ł, Fraser L, Mogielnicka Brzozowska M, Kordan W. The benefits of cooling boar semen in long-term extenders prior to cryopreservation on sperm quality characteristics. Reprod Domest Anim. 2016;51:781-8 pubmed publisher
    ..motion patterns, mitochondrial membrane potential (MMP), plasma membrane integrity (PMI) and normal apical ridge (NAR) acrosome integrity were assessed in the pre-freeze and frozen-thawed semen...
  58. Karatzanis A, Chatzidakis A, Milioni A, Vlaminck S, Kawauchi H, Velegrakis S, et al. Contemporary Use of Corticosteroids in Rhinology. Curr Allergy Asthma Rep. 2017;17:11 pubmed publisher
    ..Allergic rhinitis (AR), non-allergic rhinitis (NAR), acute rhinosinusitis (ARS), chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps, and ..
  59. Kamika I, Tekere M. Impacts of cerium oxide nanoparticles on bacterial community in activated sludge. AMB Express. 2017;7:63 pubmed publisher
    ..This was confirmed by a drastic reduction of activities for enzymes catalysing denitrification (NaR and NiR) and degradation of polyphosphate (ADK and PPK)...
  60. Lewis T, Sillitoe I, Dawson N, Lam S, Clarke T, Lee D, et al. Gene3D: Extensive prediction of globular domains in proteins. Nucleic Acids Res. 2017;: pubmed publisher
    ..Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database...
  61. Eisermann K, Dar J, Dong J, Wang D, Masoodi K, Wang Z. Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor. PLoS ONE. 2015;10:e0128495 pubmed publisher
    ..Additionally, knockdown of PABPC1 inhibited transactivation of the PSA promoter by NAR (AR lacking the LBD) and attenuated proliferation of AR-positive prostate cancer cells...
  62. Hubley R, Finn R, Clements J, Eddy S, Jones T, Bao W, et al. The Dfam database of repetitive DNA families. Nucleic Acids Res. 2016;44:D81-9 pubmed publisher
    ..The initial release of Dfam, featured in the 2013 NAR Database Issue, contained 1143 families of repetitive elements found in humans, and was used to produce more than ..
  63. Arthurs R, Ismail M, Prior C, Oganesyan V, Horton P, Coles S, et al. Enantiopure Ferrocene-Based Planar-Chiral Iridacycles: Stereospecific Control of Iridium-Centred Chirality. Chemistry. 2016;22:3065-72 pubmed publisher
    Reaction of [IrCp*Cl2 ]2 with ferrocenylimines (Fc=NAr, Ar=Ph, p-MeOC6 H4 ) results in ferrocene C-H activation and the diastereoselective synthesis of half-sandwich iridacycles of relative configuration Sp *,RIr *...
  64. Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
    ..In this study, we investigated the potential protective mechanisms of naringin (Nar), a pummelo peel extract, on LPS-induced PC12 cell apoptosis...
  65. Livingstone Z, Hernán Gómez A, Baillie S, Armstrong D, Carrella L, Clegg W, et al. Assessing the reactivity of sodium alkyl-magnesiates towards quinoxaline: single electron transfer (SET) vs. nucleophilic alkylation processes. Dalton Trans. 2016;45:6175-82 pubmed publisher
    ..the reactivity of sodium butyl-magnesiate (1) supported by the bulky chelating silyl(bisamido) ligand {Ph2Si(NAr*)2}(2-) (Ar* = 2,6-iPr2-C6H3) towards Quinoxaline (Qx), the ability of this bimetallic system to effectively ..
  66. Ha E, Na M, Lee S, Baek H, Lee S, Sheen Y, et al. Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children Sensitized to House Dust Mites. Int Arch Allergy Immunol. 2017;: pubmed publisher
    ..This study aimed to determine the prevalence, clinical characteristics, and severity of LAR in children in comparison to classical allergic rhinitis (AR) and nonallergic rhinitis (NAR).
  67. Miler M, Zivanović J, Ajdžanović V, Orescanin Dusić Z, Milenkovic D, Konic Ristic A, et al. Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Exp Gerontol. 2016;84:49-60 pubmed publisher
    This study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats...
  68. Kuczmarski M, Beydoun M, Stave Shupe E, Pohlig R, Zonderman A, Evans M. Use of Dietary Supplements Improved Diet Quality But Not Cardiovascular and Nutritional Biomarkers in Socioeconomically Diverse African American and White Adults. J Nutr Gerontol Geriatr. 2017;36:92-110 pubmed publisher
    ..was assessed by the Mean Adequacy Ratio (MAR) [Maximum score?=?100] derived from the Nutrient Adequacy Ratio (NAR) for 17 micronutrients. The MAR score for nonusers was 73.12, for supplement users based on diet alone was 74...
  69. Liu J, Yuan Y, Li B, Zhang Q, Wu L, Li X, et al. Enhanced nitrogen and phosphorus removal from municipal wastewater in an anaerobic-aerobic-anoxic sequencing batch reactor with sludge fermentation products as carbon source. Bioresour Technol. 2017;244:1158-1165 pubmed publisher
    ..8%, 99.3% and 81.2%, respectively. Nitrite accumulation ratio (NAR) reached 99.1% and sludge reduction rate reached 44.1-52.1%. Specifically, 34...
  70. Di Giammartino D, Li W, Ogami K, Yashinskie J, Hoque M, Tian B, et al. RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Genes Dev. 2014;28:2248-60 pubmed publisher
    ..Our results implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. ..
  71. Hermans T, Voskuilen C, Van Der Heijden M, Schmitz Drager B, Kassouf W, Seiler R, et al. Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future. Urol Oncol. 2018;36:413-422 pubmed publisher
    ..We summarize the evidence for neoadjuvant radiation (NAR), chemo (NAC), and immunotherapy (checkpoint inhibition) prior to RC for MIBC...
  72. Browne L, Smith K, Jagger D. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. Eneuro. 2017;4: pubmed publisher
    ..A subthreshold persistent Na+ current (INaP) and a resurgent Na+ current (INaR) both emerged prior to the onset of hearing and became more prevalent as hearing matured...
  73. Kardi S, Ibrahim N, Darzi G, Rashid N, Villaseñor J. Dye removal of AR27 with enhanced degradation and power generation in a microbial fuel cell using bioanode of treated clinoptilolite-modified graphite felt. Environ Sci Pollut Res Int. 2017;24:19444-19457 pubmed publisher
    ..The anode surfaces provided active sites for the adhesion of the bacterial consortium (NAR-2) and the biodegradation of mono azo dye C.I. Acid Red 27. As a result, bioelectricity was generated in both MFCs...
  74. Rout P, Bhunia P, Dash R. Simultaneous removal of nitrogen and phosphorous from domestic wastewater using Bacillus cereus GS-5 strain exhibiting heterotrophic nitrification, aerobic denitrification and denitrifying phosphorous removal. Bioresour Technol. 2017;244:484-495 pubmed publisher
    ..The successfully expression of hydroxylamine oxidase (hao), nitrate reductase (nar), nitrite reductase (nir) and poly phosphate kinase (ppk) enzyme in the cell free extracts and PCR amplification of ..
  75. Okuda T, Tang P, Yu J, Finlay W, Chan H. Powder aerosol delivery through nasal high-flow system: In vitro feasibility and influence of process conditions. Int J Pharm. 2017;533:187-197 pubmed publisher
    ..dispersion' air flow rates dispersed SD-Man loaded in an Osmohaler® into a human nasal airway replica (NAR) coupled downstream to a Next Generation Impactor (NGI) running at specific 'inspiratory' flow rates...
  76. Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, et al. CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway. Mol Oncol. 2016;10:317-29 pubmed publisher
    ..and immunofluorescence analyses revealed the co-localization and interaction between CBP and CPSF4 (cleavage and polyadenylation specific factor 4) proteins in lung cancer cells...
  77. Enomoto A, Seki S, Tanaka S, Ishihama K, Yamanishi T, Kogo M, et al. Development of resurgent and persistent sodium currents in mesencephalic trigeminal neurons. J Neurosci Res. 2018;96:305-312 pubmed publisher
    ..As previously reported, resurgent and persistent sodium currents (INaR and INaP , respectively) may carry small currents at subthreshold voltages that contribute to ..
  78. Tan Y, Zhang W, Jiang L, Yang J, Yan L. Efficacy and safety of anatomic resection versus nonanatomic resection in patients with hepatocellular carcinoma: A systemic review and meta-analysis. PLoS ONE. 2017;12:e0186930 pubmed publisher
    The surgical decision of performing anatomic resection (AR) or nonanatomic resection (NAR) in patients with hepatocellular carcinoma remains controversial...
  79. Munoz O. Transition to agriculture in South-Eastern Arabia: Insights from oral conditions. Am J Phys Anthropol. 2017;164:702-719 pubmed publisher
    ..4500-3100 BC) to the Early Bronze Age (EBA), conventionally divided into Hafit (ca. 3100-2700 BC) and Umm an-Nar period (ca. 2700-2000 BC)...
  80. Hermans T, Fransen van de Putte E, Horenblas S, Lemmens V, Aben K, Van Der Heijden M, et al. Perioperative treatment and radical cystectomy for bladder cancer--a population based trend analysis of 10,338 patients in the Netherlands. Eur J Cancer. 2016;54:18-26 pubmed publisher
    ..We assessed temporal trends in PT (neoadjuvant chemotherapy [NAC], neoadjuvant radiotherapy [NAR], adjuvant chemotherapy [AC], adjuvant radiotherapy [AR]) and RC in the Netherlands and identified patients' and ..
  81. Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, et al. Cleavage and polyadenylation specific factor 4 targets NF-?B/cyclooxygenase-2 signaling to promote lung cancer growth and progression. Cancer Lett. 2016;381:1-13 pubmed publisher
    ..Here we identified cleavage and polyadenylation specific factor 4 (CPSF4) as a new regulatory factor for COX-2 and demonstrated the role of the CPSF4/COX-2 signaling pathway in the ..
  82. Gelardi M, Landi M, Ciprandi G. Nasal Cytology: a Precision Medicine tool in clinical practice. Clin Exp Allergy. 2017;: pubmed publisher
    ..in defining the different sub-groups of patients suffering from allergic rhinitis (AR) and non-allergic rhinitis (NAR)...
  83. Laishram R, Anderson R. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. EMBO J. 2010;29:4132-45 pubmed publisher
    ..The data support a model where Star-PAP binds to the RNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. ..
  84. Huang X, Lu S. A Meta-analysis comparing the effect of anatomical resection vs. non-anatomical resection on the long-term outcomes for patients undergoing hepatic resection for hepatocellular carcinoma. HPB (Oxford). 2017;19:843-849 pubmed publisher
    ..aimed to compare the outcomes of patients undergoing anatomical resection (AR) versus non-anatomical resection (NAR) for hepatocellular carcinoma (HCC) from the published comparative studies within the literatures...
  85. Malik R, Linos D. Intraoperative Neuromonitoring in Thyroid Surgery: A Systematic Review. World J Surg. 2016;40:2051-8 pubmed publisher
    ..Mean specificity of IONM in identifying functional nerves was 90.24 % among 7366 nerves at risk (NAR)...
  86. Nagae H, Hato W, Kawakita K, Tsurugi H, Mashima K. Arylimido-Bridged Dinuclear Ti(?-NAr)2 Ti Scaffold for Alkyne Insertion into the ortho-C-H Bond of Arylimido Ligands. Chemistry. 2017;23:586-596 pubmed publisher
    Dinuclear titanium dialkyl complexes bridged by two ?-arylimido ligands, [CpTi(CH2 SiMe3 )(?-NAr)]2 (Cp=cyclopentadienyl) activated an ortho-aryl C-H bond of an ?-arylimido ligand to form a four-membered ..
  87. Cavalari F, da Rosa L, Escott G, Dourado T, de Castro A, Kohek M, et al. Epitestosterone- and testosterone-replacement in immature castrated rats changes main testicular developmental characteristics. Mol Cell Endocrinol. 2018;461:112-121 pubmed publisher
    ..since it inhibits the effects produced by testosterone and dihydrotestosterone via the nuclear androgen receptor (nAR)...
  88. Yin J, Liang Y, Wang D, Yan Z, Yin H, Wu D, et al. Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation. Int J Mol Med. 2018;41:649-658 pubmed publisher
    ..Naringenin (NAR), a natural flavonoid widely found in citrus fruits and tomatoes, has been reported to exhibit various ..
  89. Ai H, Zhang L, Chang A, Wei H, Che Y, Liu H. Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus. J Mol Model. 2014;20:2142 pubmed publisher
    Inhibition of CPSF30 function by the effector domain of influenza A virus of non-structural protein 1 (NS1A) protein plays a critical role in the suppression of host key antiviral response...
  90. Kim J, Lee D, Yoon S, Jeong K, Choi B, Shin K. Contribution of petroleum-derived organic carbon to sedimentary organic carbon pool in the eastern Yellow Sea (the northwestern Pacific). Chemosphere. 2017;168:1389-1399 pubmed publisher
    ..study area as shown by the low carbon preference index (CPI25-33, <1) and natural n-alkanes ratio (NAR, <-0.6) values...
  91. Wang L, Zeng X, Wang M, Brennan C, Gong D. Modification of membrane properties and fatty acids biosynthesis-related genes in Escherichia coli and Staphylococcus aureus: Implications for the antibacterial mechanism of naringenin. Biochim Biophys Acta Biomembr. 2018;1860:481-490 pubmed publisher
    ..coli) and Staphylococcus aureus ATCC 6538 (S. aureus), during growth in the presence of naringenin (NAR), one of the natural antibacterial components in citrus plants, was investigated. Compared to E...
  92. Wasilewska K, Fraser L. Boar variability in sperm cryo-tolerance after cooling of semen in different long-term extenders at various temperatures. Anim Reprod Sci. 2017;185:161-173 pubmed publisher
    ..CASA sperm variables, mitochondrial membrane potential (MMP), plasma membrane integrity (PMI), normal apical ridge (NAR) acrosome integrity, and viability (YO-PRO-1-/PI-) of sperm were assessed in the PF and PT ..