CPA1

Summary

Gene Symbol: CPA1
Description: carboxypeptidase A1
Alias: CPA, carboxypeptidase A1, carboxypeptidase A1 (pancreatic), pancreatic carboxypeptidase A
Species: human
Products:     CPA1

Top Publications

  1. Cao C, Su Y, Han D, Gao Y, Zhang M, Chen H, et al. Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways. J Ethnopharmacol. 2017;198:379-388 pubmed publisher
    ..g.). The mice in positive control group were intraperitoneal (i.p.) injected with cyclophosphamide (CPA) at a dose of 20mg/kg (b.w.)...
  2. Salilew Wondim D, Wang Q, Tesfaye D, Schellander K, Hoelker M, Hossain M, et al. Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. J Ovarian Res. 2015;8:24 pubmed publisher
    ..A total of 573 gene transcripts, including CPA1, CDH1, INSL3, AMH, ALDH1B1, INHBA, CYP17A1, RBP4, GAS6, GAS7 and GATA4, were activated while 430 others including ..
  3. Batac M, Denning D. Serious fungal infections in the Philippines. Eur J Clin Microbiol Infect Dis. 2017;36:937-941 pubmed publisher
    ..Chronic pulmonary aspergillosis (CPA), drawn from the number of tuberculosis patients, affects 77,172 people...
  4. Zaki S, Denning D. Serious fungal infections in Egypt. Eur J Clin Microbiol Infect Dis. 2017;36:971-974 pubmed publisher
    ..the survivors of pulmonary tuberculosis (TB) in Egypt in 2012, 319 new cases of chronic pulmonary aspergillosis (CPA) are likely, a prevalence of 1,005 post-TB and a total prevalence estimate of 3,015 CPA patients in all...
  5. Yoon S, Rahman M, Kwon W, Park Y, Pang M. Addition of Cryoprotectant Significantly Alters the Epididymal Sperm Proteome. PLoS ONE. 2016;11:e0152690 pubmed publisher
    ..During cryopreservation, addition of cryoprotective agent (CPA) is crucial for protecting spermatozoa from freezing damage...
  6. Santos E, Rodriguez A, Prieto C, Gil M, Fruhbeck G, Quiroga J, et al. [Factors modulating food intake and energy expenditure prior to liver transplantation]. An Sist Sanit Navar. 2016;39:105-14 pubmed publisher
    ..They were classified according to Child-Pugh(CP) score from low to high liver dysfunction in CPA (n=4),CPB (n=11) and CPC (n=6)...
  7. Gugnani H, Denning D. Estimated Burden of Serious Fungal Infections in Jamaica by Literature Review and Modelling. West Indian Med J. 2015;64:245-9 pubmed publisher
    ..Chronic pulmonary aspergillosis (CPA), allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS) rates were ..
  8. Li L, Bai S, Sheline C. hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn2+ and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins. Diabetes. 2017;66:551-559 pubmed publisher
    ..hZnT8WT) induced nucleoside diphosphate kinase B, and Zn2+ reduction (hZnT8RW) induced carboxypeptidase A1. These data suggest that pancreatic Zn2+ and proinsulin levels covary but are inversely variant ..
  9. Li J, Ren J, Sun W. A comparative systematic review of Yasmin (drospirenone pill) versus standard treatment options for symptoms of polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2017;210:13-21 pubmed publisher
    ..DRSP was superior to cyproterone acetate (CPA) in reducing TC and homeostasis model assessment of insulin resistance (HOMA-IR)...

More Information

Publications149 found, 100 shown here

  1. Gamaletsou M, Denning D. Gastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?. Mycopathologia. 2017;182:1125-1129 pubmed publisher
    ..the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis...
  2. Yang S, Shi M, Cao J, Su J, Zhao L, Lei B, et al. [Establishment of a novel chinese human lung adenocarcinoma cell line CPA-Yang3 and its real bone metastasis clone CPA-Yang3BM in immunodeficient mice]. Zhongguo Fei Ai Za Zhi. 2011;14:79-85 pubmed publisher
    ..The novel cell was named CPA-Yang3...
  3. de Azevedo P, Sylvestre T, Cavalcante R, de Carvalho L, Moris D, de Oliveira M, et al. Evaluation of the Double Agar Gel Immunodiffusion Test and of the Enzyme-Linked Immunosorbent Assay in the Diagnosis and Follow-Up of Patients with Chronic Pulmonary Aspergillosis. PLoS ONE. 2015;10:e0134841 pubmed publisher
    The diagnosis of chronic pulmonary aspergillosis (CPA) depends on the radiologic image and the identification of specific antibodies...
  4. Li Y, Ruan X, Wang H, Li X, Cai G, Du J, et al. Comparing the risk of adverse pregnancy outcomes of Chinese patients with polycystic ovary syndrome with and without antiandrogenic pretreatment. Fertil Steril. 2018;109:720-727 pubmed publisher
    ..could be decreased in patients with polycystic ovary syndrome (PCOS) by ethinylestradiol/cyproterone acetate (EE/CPA) pretreatment. Retrospective study. Medical university...
  5. Das A, Ali N. Combining cationic liposomal delivery with MPL-TDM for cysteine protease cocktail vaccination against Leishmania donovani: evidence for antigen synergy and protection. PLoS Negl Trop Dis. 2014;8:e3091 pubmed publisher
    ..donovani in a hamster model. Recombinant CPs type I (cpb), II (cpa) and III (cpc) of L...
  6. Gugnani H, Denning D. Burden of serious fungal infections in the Dominican Republic. J Infect Public Health. 2016;9:7-12 pubmed publisher
    ..The chronic pulmonary aspergillosis (CPA), allergic bronchopulmonary aspergillosis (ABPA), and severe asthma with fungal sensitization (SAFS) rates were ..
  7. Fan W, Ma X, Ge D, Liu T, Cui Z. Cryoprotectants for the vitrification of corneal endothelial cells. Cryobiology. 2009;58:28-36 pubmed publisher
    ..Fresh bovine CECs were isolated and tested with an optimized vitrification protocol with multi-step CPA loading and removal. Three types of CPAs components, i.e...
  8. Talbot N, Shannon A, Phillips C, Garrett W. Feeder-cell-independent culture of the pig embryonic stem cell-derived exocrine pancreatic cell line, PICM-31. In Vitro Cell Dev Biol Anim. 2018;54:321-330 pubmed publisher
    ..The cells maintained their expression of digestive enzymes, including carboxypeptidase A1 (CPA1), amylase 2A (AMY2A), and phospholipase A2 (PLA2G1B)...
  9. Vyas F, Hargreaves A, Bonner P, Boocock D, Coveney C, Dickenson J. A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: A role in cell survival. Biochem Pharmacol. 2016;107:41-58 pubmed publisher
    ..H9c2 cells were lysed following stimulation with the A1 adenosine receptor agonist N(6)-cyclopentyladenosine (CPA). Transglutaminase activity was determined using an amine incorporating and a protein cross linking assay...
  10. Shahbazi M, Zahedifard F, Taheri T, Taslimi Y, Jamshidi S, Shirian S, et al. Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis. PLoS ONE. 2015;10:e0132794 pubmed publisher
    ..tarentolae expressing the L. donovani A2 antigen along with cysteine proteinase genes (CPA and CPB without its unusual C-terminal extension (CPB-CTE) and evaluated its immunogenicity and protective immunity ..
  11. Song Y, Wang Q, Wang D, Junqiang Li -, Yang J, Li H, et al. Label-Free Quantitative Proteomics Unravels Carboxypeptidases as the Novel Biomarker in Pancreatic Ductal Adenocarcinoma. Transl Oncol. 2018;11:691-699 pubmed publisher
    ..network analysis highlighted the dysregulation of a set of four proteins in the carboxypeptidase family: carboxypeptidase A1 (CPA1), A2 (CPA2), B1 (CPB1), and chymotrypsin C (CTRC)...
  12. Barberini M, Sigaut L, Huang W, Mangano S, Juárez S, Marzol E, et al. Calcium dynamics in tomato pollen tubes using the Yellow Cameleon 3.6 sensor. Plant Reprod. 2018;31:159-169 pubmed publisher
    ..We found that cyclopiazonic acid (CPA), a drug that inhibits plant PIIA-type Ca2+-ATPases, increased [Ca2+]cyt..
  13. Felizola S, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, et al. Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues. Endocr Pathol. 2015;26:119-28 pubmed publisher
    ..adrenals (NA), 6 adrenal glands with idiopathic hyperaldosteronism (IHA), 18 APA, 5 cortisol-producing adenomas (CPA), and 5 nonpathological human cerebellum specimens...
  14. Zitzmann M, Rohayem J, Raidt J, Kliesch S, Kumar N, Sitruk Ware R, et al. Impact of various progestins with or without transdermal testosterone on gonadotropin levels for non-invasive hormonal male contraception: a randomized clinical trial. Andrology. 2017;5:516-526 pubmed publisher
    ..four oral or transdermal progestins on the suppression of gonadotropins in healthy men: oral: cyproterone acetate (CPA), levonorgestrel (LNG), norethisterone acetate (NETA), and transdermal: Nestorone® (NES), all in ..
  15. Han D, Cao C, Su Y, Wang J, Sun J, Chen H, et al. Ginkgo biloba exocarp extracts inhibits angiogenesis and its effects on Wnt/?-catenin-VEGF signaling pathway in Lewis lung cancer. J Ethnopharmacol. 2016;192:406-412 pubmed publisher
    ..1mL/10g (b.w.), positive group were intraperitoneal (i.p.) injection cyclophosphamide (CPA) at a dose of 20mg/kg (b.w.) , the GBEE treatment groups were respectively i.g. GBEE 50, 100, and 200mg/kg (b.w...
  16. Navarro M, McClane B, Uzal F. Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins. Toxins (Basel). 2018;10: pubmed publisher
    ..The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (CPE), and necrotic B-like (NetB) toxins...
  17. Badiane A, Ndiaye D, Denning D. Burden of fungal infections in Senegal. Mycoses. 2015;58 Suppl 5:63-9 pubmed publisher
    ..We estimate 685 incident cases of chronic pulmonary aspergillosis (CPA) following TB and prevalence of 2160 cases. Asthma prevalence in adults varies from 3.2% to 8...
  18. Sacarlal J, Denning D. Estimated Burden of Serious Fungal Infections in Mozambique. J Fungi (Basel). 2018;4: pubmed publisher
    ..used to estimate the burden of allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA). In 2016, the Mozambique population was 26.4 million with 1.8 million people reported to be HIV-infected...
  19. McHugh W, Russell W, Fleszar A, Rodenhouse P, Rietberg S, Sun L, et al. Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016;311:L903-L912 pubmed publisher
    ..N6-cyclopentyladenosine (N6-CPA) increased PP2A activity and inhibited endotoxin-induced cytokine production in a murine alveolar macrophage cell ..
  20. Deep N, Graffeo C, Copeland W, Link M, Atkinson J, Neff B, et al. Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression. Laryngoscope. 2017;127:715-719 pubmed publisher
    ..MVD) for hemifacial spasm who presented with Teflon granulomas (TG) mimicking cerebellopontine angle (CPA) tumors and to perform a systematic review of the English-language literature...
  21. Doloff J, Waxman D. Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts. BMC Cancer. 2015;15:375 pubmed publisher
    ..as were several immunosuppressive factors that may contribute to the observed escape of some tumors from metronomic CPA-induced, immune-based regression...
  22. Chamcha V, Jones A, Quigley B, Scott J, Amara R. Oral Immunization with a Recombinant Lactococcus lactis-Expressing HIV-1 Antigen on Group A Streptococcus Pilus Induces Strong Mucosal Immunity in the Gut. J Immunol. 2015;195:5025-34 pubmed publisher
    ..We expressed the HIV-1 Gag-p24 on the tip of the T3 pilus of Streptococcus pyogenes as a fusion to the Cpa protein (LL-Gag)...
  23. Nieves Cordones M, Al Shiblawi F, Sentenac H. Roles and Transport of Sodium and Potassium in Plants. Met Ions Life Sci. 2016;16:291-324 pubmed publisher
    ..Three families of ion channels (Shaker, TPK/KCO, and TPC) and 3 families of transporters (HAK, HKT, and CPA) have been identified so far as contributing to K(+) and Na(+) transport across the plasmalemma and internal ..
  24. Naaldijk Y, Johnson A, Friedrich Stöckigt A, Stolzing A. Cryopreservation of dermal fibroblasts and keratinocytes in hydroxyethyl starch-based cryoprotectants. BMC Biotechnol. 2016;16:85 pubmed
    ..For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative...
  25. Witt H, Beer S, Rosendahl J, Chen J, Chandak G, Masamune A, et al. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet. 2013;45:1216-20 pubmed publisher
    Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1, encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and controls in a German discovery set and three replication ..
  26. Wang Y, Wang Y, Ma A, Li D, Ye C. Rapid and sensitive detection of Listeria monocytogenes by cross-priming amplification of lmo0733 gene. FEMS Microbiol Lett. 2014;361:43-51 pubmed
    ..This study reports the development of single cross-priming amplification (S-CPA) and double CPA (D-CPA) assays targeting species-specific gene lmo0733 for identifying L. monocytogenes strains...
  27. DeOliveira C, Paiva Caria C, Ferreira Gotardo E, Ribeiro M, Gambero A. Role of A1 and A2A adenosine receptor agonists in adipose tissue inflammation induced by obesity in mice. Eur J Pharmacol. 2017;799:154-159 pubmed publisher
    ..The aim of this study was to evaluate the activity of N6-cyclopentyladenosine (CPA), a potent and selective A1 adenosine receptor agonist; 2-p-(2-carboxyethyl)phenethylamino-5'-N-..
  28. Alimolaei M, Golchin M, Abshenas J, Ezatkhah M, Bafti M. A Recombinant Probiotic, Lactobacillus casei, Expressing the Clostridium perfringens ?-toxoid, as an Orally Vaccine Candidate Against Gas Gangrene and Necrotic Enteritis. Probiotics Antimicrob Proteins. 2018;10:251-257 pubmed publisher
    ..The C-terminal domain of this toxin ( cpa 247-370 ) was synthesized and cloned into pT1NX vector to construct the pT1NX-alpha plasmid...
  29. Liu W, Zhou Y, Fan Y, Jiang N, Cain K, Zeng L. Development of cross-priming amplification coupled with vertical flow visualization for rapid detection of infectious spleen and kidney necrosis virus (ISKNV) in mandarin fish, Siniperca chuatsi. J Virol Methods. 2018;253:38-42 pubmed publisher
    ..cross priming amplification coupled with vertical flow visualization for rapid identification of ISKNV (ISKNV-CPA-VF)...
  30. Zhao Y, Liu P, Zhang N, Chen J, Landegger L, Wu L, et al. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A. 2018;115:E2077-E2084 pubmed publisher
    ..Here, we developed a cerebellopontine angle (CPA) schwannoma model that faithfully recapitulates the tumor-induced hearing loss...
  31. Sekula B, Ciesielska A, Rytczak P, Koziołkiewicz M, Bujacz A. Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties. Biosci Rep. 2016;36: pubmed publisher
    ..the detailed interactions between human serum albumin (HSA) and equine serum albumin (ESA) with a derivative of cPA, 1-O-myristoyl-sn-glycerol-2,3-cyclic phosphorodithioate (Myr-2S-cPA)...
  32. Winata C, Łapiński M, Pryszcz L, Vaz C, Bin Ismail M, Nama S, et al. Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal-to-zygotic transition. Development. 2018;145: pubmed publisher
    ..These maternal mRNAs undergo cytoplasmic polyadenylation (CPA), suggesting translational control of their activation...
  33. Bongomin F, Harris C, Foden P, Kosmidis C, Denning D. Innate and Adaptive Immune Defects in Chronic Pulmonary Aspergillosis. J Fungi (Basel). 2017;3: pubmed publisher
    ..immune response in correlation with underlying conditions in 144 patients with chronic pulmonary aspergillosis (CPA)...
  34. Kong J, Whelan K, Laczkó D, Dang B, Caro Monroig A, Soroush A, et al. Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Mol Carcinog. 2016;55:1526-1541 pubmed publisher
    ..To demonstrate a functional role for autophagy in BE pathogenesis, normal squamous (STR), non-dysplastic BE (CPA), dysplastic BE (CPD), and EAC (OE19) cell lines were exposed to an acid pulse (pH 3...
  35. Takeda K, Imamura Y, Takazono T, Yoshida M, Ide S, Hirano K, et al. The risk factors for developing of chronic pulmonary aspergillosis in nontuberculous mycobacteria patients and clinical characteristics and outcomes in chronic pulmonary aspergillosis patients coinfected with nontuberculous mycobacteria. Med Mycol. 2016;54:120-7 pubmed publisher
    Patients with chronic pulmonary aspergillosis (CPA) have a poor prognosis and CPA occurs in patients with various underlying diseases...
  36. Iaffaldano N, Di Iorio M, Miranda M, Zaniboni L, Manchisi A, Cerolini S. Cryopreserving turkey semen in straws and nitrogen vapour using DMSO or DMA: effects of cryoprotectant concentration, freezing rate and thawing rate on post-thaw semen quality. Br Poult Sci. 2016;57:264-70 pubmed publisher
    ..nitrogen vapour by examining the effects of dimethylacetamide (DMA) or dimethylsulfoxide (DMSO) as cryoprotectant (CPA), CPA concentration, freezing rate and thawing rate on in vitro post-thaw semen quality. 2...
  37. Noguchi M, Moriya F, Koga N, Matsueda S, Sasada T, Yamada A, et al. A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer. Cancer Immunol Immunother. 2016;65:151-60 pubmed publisher
    This study investigated the effect of metronomic cyclophosphamide (CPA) in combination with personalized peptide vaccination (PPV) on regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC), and whether it could improve the ..
  38. Bingham J, Mallette J. Federal Bureau of Prisons clinical pharmacy program improves patient A1C. J Am Pharm Assoc (2003). 2016;56:173-7 pubmed publisher
    ..via pharmacist clinicians working under the auspices of a physician-pharmacist collaborative practice agreement (CPA)...
  39. Chan J, Lau S, Wong S, To K, So S, Leung S, et al. A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis. Emerg Microbes Infect. 2016;5:e37 pubmed publisher
    ..has increased markedly. Although chronic pulmonary aspergillosis (CPA) is considered a 'semi-invasive' or 'intermediate' disease, little data are available for the direct comparison of ..
  40. de Mello F, Garcia J, Godoy L, Depince A, Labbe C, Streit D. The effect of cryoprotectant agents on DNA methylation patterns and progeny development in the spermatozoa of Colossoma macropomum. Gen Comp Endocrinol. 2017;245:94-101 pubmed publisher
    ..DNA methylation pattern alterations affected the viability of progeny (r=0.48); however, these effects can be minimized by choosing the CPA that will compose the freezing solution.
  41. Lowes D, Al shair K, Newton P, Morris J, Harris C, Rautemaa Richardson R, et al. Predictors of mortality in chronic pulmonary aspergillosis. Eur Respir J. 2017;49: pubmed publisher
    Chronic pulmonary aspergillosis (CPA) is a chronic progressive infection that destroys lung tissue in non-immunocompromised patients. Contemporary series suggest 50-85% 5-year mortality, with few prognostic factors identified...
  42. Ewald A, Bosch P, Culverhouse A, Crowley R, Neuenswander B, Prisinzano T, et al. The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and ?-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects. Psychopharmacology (Berl). 2017;234:2499-2514 pubmed publisher
    ..THP Sal B were evaluated for aversive, anxiogenic and depressive-like effects using conditioned place aversion (CPA), elevated plus maze (EPM) and forced swim tests (FSTs), respectively. EOM Sal B (0.1, 0...
  43. Rahman S, Strüssmann C, Suzuki T, Majhi S, Hattori R, Alam M. Effects of ultrasound on permeation of cryoprotectants into Japanese whiting Sillago japonica embryos. Cryobiology. 2017;77:19-24 pubmed publisher
    Cryopreservation of fish embryos requires the swift uptake of considerable amounts of cryoprotectant (CPA) but this process is hampered by the low permeability of the egg chorion...
  44. Tochigi N, Ishiwatari T, Okubo Y, Ando T, Shinozaki M, Aki K, et al. Histological study of chronic pulmonary aspergillosis. Diagn Pathol. 2015;10:153 pubmed publisher
    Chronic pulmonary aspergillosis (CPA) has been accepted the criteria for the diagnosis of pulmonary Aspergillus infection. Whereas, either pathophysiology or signs of CPA remains still controversial...
  45. Searl T, Dynda D, Alanee S, El Zawahry A, McVary K, Silinsky E. A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder. J Pharmacol Exp Ther. 2016;356:116-22 pubmed publisher
    ..by the selective A1 adenosine receptor agonists 2-chloro-N(6)-cyclopentyladenosine, N(6)-cyclopentyladenosine (CPA), and adenosine (rank order of potency: 2-chloro-N(6)-cyclopentyladenosine > CPA > adenosine)...
  46. Bilaj F, Rroji A, Enesi E, Ruka M, Petrela M. Cerebral proliferative angiopathy with tumor-like hemorrhage: A case report and literature review. Neuroradiol J. 2016;29:336-9 pubmed publisher
    Cerebral proliferative angiopathy (CPA) is defined as a rare vascular disorder, characterized by diffuse arterial proliferation and distinctive angiogenetic features...
  47. Kosmidis C, Muldoon E. Challenges in the management of chronic pulmonary aspergillosis. Med Mycol. 2017;55:63-68 pubmed
    The management of chronic pulmonary aspergillosis (CPA) presents multiple challenges...
  48. Vallejos Baier R, Picao Osorio J, Alonso C. Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System. J Mol Biol. 2017;429:3290-3300 pubmed publisher
    ..within the Drosophila nervous system, focusing on the roles played by general cleavage and polyadenylation factors (CPA factors)...
  49. Schneider H, Fischer D, Failing K, Ehling C, Meinecke Tillmann S, Wehrend A, et al. Investigations on a cryopreservation protocol for long-term storage of psittacine spermatozoa using cockatiel semen as an example. Theriogenology. 2018;110:8-17 pubmed publisher
    ..Altogether, 96 incremental diluted semen samples were obtained for investigation. Each cryoprotective agent (CPA) in each final concentration was evaluated regarding sperm motility immediately after dilution and another four ..
  50. Catasus L, Villegas V, Pascual R, Aviles F, Wicker Planquart C, Puigserver A. cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1. Biochem J. 1992;287 ( Pt 1):299-303 pubmed
  51. Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, et al. Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy. J Immunol. 2015;195:726-35 pubmed publisher
    ..Cyclophosphamide (CPA) treatment depleted lymphocytes more efficiently than other cytotoxic agents; however, the percentage of CD4(+)CD25(..
  52. Zarandi M, Cai R, Kovacs M, Popovics P, Szalontay L, Cui T, et al. Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth. Peptides. 2017;89:60-70 pubmed publisher
    ..We incorporated pentafluoro-Phe (Fpa5), instead of Cpa, at position 6 and Tyr(Me) at position 10 and ?-amino acids at N-terminus of some analogs...
  53. Adams S, Tervit H, McGowan L, Smith J, Roberts R, Salinas Flores L, et al. Towards cryopreservation of Greenshell mussel (Perna canaliculus) oocytes. Cryobiology. 2009;58:69-74 pubmed publisher
    ..Fertilization losses occurred at each step whereas D-larval yield approximately halved following CPA addition and was almost zero following cooling to -10 degrees C...
  54. Siegenthaler P, Bain P, Riva F, Fent K. Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17?-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio. Aquat Toxicol. 2017;182:142-162 pubmed publisher
    ..antiandrogenic progestin, chlormadinone acetate (CMA), and the antiandrogenic progestin cyproterone acetate (CPA)...
  55. de Godoy I, de Campos C, Pescador C, Galceran J, Cândido S, Dutra V, et al. Experimental infection in gerbils by Conidiobolus lamprauges. Microb Pathog. 2017;105:251-254 pubmed publisher
    ..The study animals were randomly divided into four groups of four animals: immunosuppressed with cyclophosphamide (CPA) and infected with C. lamprauges (G1), immunocompetent and infected with C...
  56. Yang Y, Zhou X, Zhou N, Shao W, Tao L. Numerical and Experimental Investigation on Water-Me2SO Mixing in Microfluidic Device for Oocyte Cryopreservation. Cryo Letters. 2017;38:37-42 pubmed
    ..Me2SO containing 1mM fluorescence dye FITC were mixed using the microfluidic device to verify the CPA diffusion behavior...
  57. Alonso F, Kassem M, Iwanaga J, Oskouian R, Loukas M, Demerdash A, et al. Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex. Cureus. 2017;9:e1570 pubmed publisher
    Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms...
  58. Maximino C, Meinerz D, Fontana B, Mezzomo N, Stefanello F, de S Prestes A, et al. Extending the analysis of zebrafish behavioral endophenotypes for modeling psychiatric disorders: Fear conditioning to conspecific alarm response. Behav Processes. 2018;149:35-42 pubmed publisher
    ..to conspecific alarm substance (CAS) produces fear conditioning in zebrafish using a conditioned place aversion (CPA) paradigm, as well as the persistence of aversive responses at different time intervals...
  59. Kawamura Y, Miura H, Matsumoto Y, Uchida H, Kudo K, Hata T, et al. A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. BMC Pediatr. 2016;16:172 pubmed
    ..During treatment according to HLH-2004 protocol, sudden cardiopulmonary arrest (CPA) occurred on day 30 of the illness and immediate resuscitation was successful...
  60. Master A, Hamiter M, Cosetti M. Defining the Limits of Endoscopic Access to Internal Auditory Canal. J Int Adv Otol. 2016;12:298-302 pubmed publisher
    ..The dissection proceeded until the cerebellopontine angle (CPA) could be accessed. Following dissection, all the specimens were subjected to computed tomography (CT) imaging...
  61. Niklaus R, Minár J, Häusler J, Schnick W. First-principles and experimental characterization of the electronic properties of CaGaSiN3 and CaAlSiN3: the impact of chemical disorder. Phys Chem Chem Phys. 2017;19:9292-9299 pubmed publisher
    ..experimentally observed substitutional disorder is accounted for by utilizing the Coherent Potential Approximation (CPA)...
  62. Beyer Berjot L, Pucher P, Patel V, Hashimoto D, Ziprin P, Berdah S, et al. Colorectal surgery and enhanced recovery: Impact of a simulation-based care pathway training curriculum. J Visc Surg. 2017;154:313-320 pubmed publisher
    The aim was to determine whether a simulation-based care pathway approach (CPA) curriculum could improve compliance for enhanced recovery programs (ERP), and residents' participation in laparoscopic colorectal surgery (LCS)...
  63. Pallares I, Fernandez D, Comellas Bigler M, Fernandez Recio J, Ventura S, Aviles F, et al. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). Acta Crystallogr D Biol Crystallogr. 2008;D64:784-91 pubmed publisher
    b>Carboxypeptidase A1 has been the subject of extensive research in the last 30 y and is one of the most widely studied zinc metalloenzymes. However, the three-dimensional structure of the human form of the enzyme is not yet available...
  64. Carneiro C, da Costa Santos S, de Souza Lino R, Bara M, Chaibub B, de Melo Reis P, et al. Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil. Toxicol Appl Pharmacol. 2016;310:1-8 pubmed publisher
    ..punicalagin (50mg/kg) showed significant cytotoxic effect by MN test and in the co-treatment with cyclophosphamide (CPA), this cytotoxicity was enhanced...
  65. Gotor Vila A, Teixidó N, Sisquella M, Torres R, Usall J. Biological Characterization of the Biocontrol Agent Bacillus amyloliquefaciens CPA-8: The Effect of Temperature, pH and Water Activity on Growth, Susceptibility to Antibiotics and Detection of Enterotoxic Genes. Curr Microbiol. 2017;74:1089-1099 pubmed publisher
    This work focuses on the biological understanding of the biocontrol agent Bacillus amyloliquefaciens CPA-8 in order to accomplish the characterization required in the registration process for the development of a microorganism-based ..
  66. DeVuono M, Wills K, MacPherson D, Hrelja K, Parker L. Effect of footshock stress on place conditioning produced by ?9-tetrahydrocannabinol and the fatty acid amide hydrolase (FAAH) inhibitor, URB597, in Sprague-Dawley rats. Psychopharmacology (Berl). 2017;234:3229-3240 pubmed publisher
    ..A dose of 1 mg/kg THC, but not 0.1-0.5 mg/kg, produced a conditioned place aversion (CPA) that was not modified by footshock delivered 24 h prior to conditioning trials; however, footshock delivered ..
  67. Chintapalli V, Kato A, Henderson L, Hirata T, Woods D, Overend G, et al. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proc Natl Acad Sci U S A. 2015;112:11720-5 pubmed publisher
    The cation/proton antiporter (CPA) family includes the well-known sodium/proton exchanger (NHE; SLC9A) family of Na(+)/H(+) exchangers, and the more recently discovered and less well understood CPA2s (SLC9B), found widely in living ..
  68. Ye X, Liu X, Deng X, Lin F, Wang S, Zhang D, et al. [The clinical application of retractorless surgical technique in neurosurgical operation]. Zhonghua Yi Xue Za Zhi. 2015;95:1976-9 pubmed
    ..Fifteen patients with cerebellopontine angle (CPA) tumors were treated by retrosigmoid approaches...
  69. Serafim K, Russo P, Fernandes C, Gianlorenço A, Mattioli R. Intra-amygdala microinjections of chlorpheniramine impair memory formation or memory retrieval in anxiety- and fear-mediated models. Brain Res Bull. 2016;125:127-33 pubmed publisher
    H1 receptor histaminergic antagonist, chlorpheniramine (CPA) participates in cognitive performance in various animal models. However, little is known regarding the effects of CPA microinjection into the amygdala on emotional behavior...
  70. Wang D, Yue Y, Wu G, Tian Y, Liu Y, Yu J, et al. Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha-toxin. Toxicon. 2017;130:79-86 pubmed publisher
    ..The equilibrium association constant between scFv and CPA was 2.02 × 1010 (1/M), as analyzed by SPR...
  71. Jomha N, Law G, Abazari A, Rekieh K, Elliott J, McGann L. Permeation of several cryoprotectant agents into porcine articular cartilage. Cryobiology. 2009;58:110-114 pubmed publisher
    ..The cartilage was isolated and the amount of CPA within the matrix was determined. Diffusion coefficients (DMSO=2.4-6.2x10(-6)cm2/s; PG=0.8-2.7x10(-6)cm2/s; EG=1...
  72. Koyama K, Ohshima N, Suzuki J, Kawashima M, Okuda K, Sato R, et al. Evaluation of clinical characteristics and prognosis of chronic pulmonary aspergillosis depending on the underlying lung diseases: Emphysema vs prior tuberculosis. J Infect Chemother. 2015;21:795-801 pubmed publisher
    ..data evaluating the differences of clinical characteristics and prognosis of chronic pulmonary aspergillosis (CPA) depending on underlying pulmonary diseases...
  73. Schmitner N, Kohno K, Meyer D. ptf1a+ , ela3l- cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae. Dis Model Mech. 2017;10:307-321 pubmed publisher
    ..Rather, a rare population of slowly dividing ela3l-negative cells expressing ptf1a and CPA was identified as the origin of the newly forming exocrine cells...
  74. Witkowski B, Gierczak T. cis-Pinonic Acid Oxidation by Hydroxyl Radicals in the Aqueous Phase under Acidic and Basic Conditions: Kinetics and Mechanism. Environ Sci Technol. 2017;51:9765-9773 pubmed publisher
    Aqueous-phase oxidation of cis-pinonic acid (CPA) by hydroxyl radicals (OH) was studied using a relative rate technique under acidic and basic conditions...
  75. Rodrigues J, Camara H, Jurkiewicz A, Godinho R. Increased Gi protein signaling potentiates the negative chronotropic effect of adenosine in the SHR right atrium. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:513-522 pubmed publisher
    ..Our results showed that adenosine, the endogenous agonist of adenosine receptors, and CPA, a selective agonist of A1 receptor, decreased the atrial chronotropism of NWR and SHR in a ..
  76. Jackson K, Jackson A, Carroll F, Damaj M. Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice. Neuropharmacology. 2015;97:270-4 pubmed publisher
    ..withdrawal signs were measured using a spontaneous nicotine withdrawal model and conditioned place aversion (CPA) following pre-treatment with LY2456302, administered orally...
  77. Wang T, Zhao G, Tang H, Jiang Z. DETERMINATION OF CONVECTIVE HEAT TRANSFER COEFFICIENT AT THE OUTER SURFACE OF A CRYOVIAL BEING PLUNGED INTO LIQUID NITROGEN. Cryo Letters. 2015;36:285-8 pubmed
    ..it is difficult to model the heat transfer process or to predict the cooling curve of a cryoprotective agent (CPA) solution due to the uncertainty of its convective heat transfer coefficient (h)...
  78. Yan L, Wang A, Bai R, Shang W, Zhao Y, Wang W, et al. Application of SonoVue combined with three-dimensional color power angiography in the diagnosis and prognosis evaluation of intrauterine adhesion. Eur J Obstet Gynecol Reprod Biol. 2016;198:68-72 pubmed publisher
    To investigate the significance of the related indexes of three-dimensional color power angiography (3D-CPA) combined with SonoVue angiography in the diagnosis and prognosis evaluation of intrauterine adhesion (IUA)...
  79. Chaudhary P, Kumar R, Sagar V, Sarkar S, Singh R, Ghosh S, et al. Assessment of Cpa, Scl1 and Scl2 in clinical group A streptococcus isolates and patients from north India: an evaluation of the host pathogen interaction. Res Microbiol. 2018;169:11-19 pubmed publisher
    ..It uses different adhesins and virulence factors like Cpa (collagen binding protein) and Scl (collagen-like protein) in its pathogenicity...
  80. Uysal F, Ozturk S. DNA Methyltransferases in Mammalian Oocytes. Results Probl Cell Differ. 2017;63:211-222 pubmed publisher
    ..CpG) dinucleotide sites and rarely occurs at cytosine-phosphate-thymine (CpT), cytosine-phosphate-adenine (CpA), or cytosine-phosphate-cytosine sites, known as non-CpG sites...
  81. Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, et al. Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia. Sci Rep. 2017;7:11205 pubmed publisher
    ..the CYP11B1 expression was regulated through DNA methylation in hypercortisolemia with cortisol-producing adenoma (CPA), and to investigate a possible relationship between DNA methylation and somatic mutations identified in CPA...
  82. Li D, Tang S, Liao Q, Chen W, Zhang H. [Literature study on prevention and treatment of community acquired pneumonia by traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2017;42:1418-1422 pubmed publisher
    ..interaction in CAP every period, which resulted from classified analysis of basic studies about Chinese medicine treatment in CPA. This study is aimed to provides an important basis for clarifying the direction of scientific research.
  83. Yin Y, Ren X, Chew A, Li J, Wang Y, Zhuang F, et al. Generation of octave-spanning mid-infrared pulses from cascaded second-order nonlinear processes in a single crystal. Sci Rep. 2017;7:11097 pubmed publisher
    ..expected to have passive stable carrier-envelope phase, which can be used to seed either a chirped pulse amplifier (CPA) or an optical parametric chirped pulse amplifier (OPCPA) for achieving high-energy few-cycle mid-infrared pulses...
  84. Mancini I, Rotilio A, Coati I, Seracchioli R, Martelli V, Meriggiola M. Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review. Gynecol Endocrinol. 2017;:1-4 pubmed publisher
    The administration of cyproterone acetate (CPA) and estradiol is a common regimen used by male-to-female transsexuals (transwoman) to adjust their body to their gender identity...
  85. Piña Batista K, de Eulate Beramendi S, Rico M, Rodrigo V, Batista Batista Y, Alvarez Reyes K. Atypical bilateral cerebellopontine angle medulloblastoma: differential diagnosis, immunohistochemical features and radiological presentation. Contemp Oncol (Pozn). 2017;21:249-253 pubmed publisher
    ..We report a case of multicentric MB involving the bilateral cerebellopontine angle (CPA) and right cerebellar hemisphere...
  86. Mialon M, Swinburn B, Wate J, Tukana I, Sacks G. Analysis of the corporate political activity of major food industry actors in Fiji. Global Health. 2016;12:18 pubmed publisher
    ..The "corporate political activity" (CPA) of the food industry includes six strategies (information and messaging; financial incentives; constituency ..
  87. Cui R, Wang Y, Wang L, Li G, Lan K, Altmeyer R, et al. Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus. Antiviral Res. 2016;132:38-45 pubmed publisher
    ..cell-based assay that measures inhibition of RSV-induced cytopathic effect (CPE) and identified cyclopiazonic acid (CPA), an intracellular calcium ATPase inhibitor as a RSV inhibitor (EC50 values 4...
  88. Masamune A. Genetics of pancreatitis: the 2014 update. Tohoku J Exp Med. 2014;232:69-77 pubmed
    ..In 2013, carboxypeptidase A1 (CPA1) was identified as a novel pancreatitis susceptibility gene...
  89. Vesper A, Lacroix J, C Gaudreault R, Tajmir Rihai H, Bérubé G. Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines. Steroids. 2016;115:98-104 pubmed publisher
    ..On these cell lines, this dimer is about 12, 70 and 47 times more powerful than cyproterone acetate (CPA) the reference antiandrogen...
  90. Yii A, Koh M, Lapperre T, Tan G, Chotirmall S. The emergence of Aspergillus species in chronic respiratory disease. Front Biosci (Schol Ed). 2017;9:127-138 pubmed
    ..prevalent in chronic obstructive pulmonary disease (COPD) predisposes to chronic pulmonary aspergillosis (CPA)...
  91. Li L, Chen Z, Zhang M, Panhwar F, Gao C, Zhao G, et al. Cell membrane permeability coefficients determined by single-step osmotic shift are not applicable for optimization of multi-step addition of cryoprotective agents: As revealed by HepG2 cells. Cryobiology. 2017;79:82-86 pubmed publisher
    ..We found that the permeability yielded via one-step addition of the Me2SO cannot exactly predict the volume change of the cells when the CPA was added in multiple steps.
  92. Huo Y, Li G, Qiu Y, Li W, Zhang Y. Rapid Detection of Prunus Necrotic Ringspot Virus by Reverse Transcription-cross-priming Amplification Coupled with Nucleic Acid Test Strip Cassette. Sci Rep. 2017;7:16175 pubmed publisher
    ..In this study, we developed a diagnostic system RT-CPA-NATSC, wherein reverse transcription-cross-priming amplification (RT-CPA) is coupled with nucleic acid test strip ..