COX5A

Summary

Gene Symbol: COX5A
Description: cytochrome c oxidase subunit 5A
Alias: COX, COX-VA, cytochrome c oxidase subunit 5A, mitochondrial, cytochrome c oxidase polypeptide Va, cytochrome c oxidase polypeptide, mitochondrial, cytochrome c oxidase subunit Va, mitochondrial cytochrome c oxidase subunit Va
Species: human
Products:     COX5A

Top Publications

  1. Chen Z, Pervaiz S. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 2010;17:408-20 pubmed publisher
    ..In this study, we show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells...
  2. Rizzuto R, Nakase H, Zeviani M, DiMauro S, Schon E. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. Gene. 1988;69:245-56 pubmed
    ..clone specifying the nuclear-encoded subunit Va of the human mitochondrial respiratory enzyme cytochrome c oxidase (COX; EC 1.9.3.1.)...
  3. Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H, Zeman J. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. Biochem J. 2010;428:363-74 pubmed publisher
    ..CcO subunits in the assembly and function of the human complex, we used stable RNA interference of COX4, COX5A and COX6A1, as well as expression of epitope-tagged Cox6a, Cox7a and Cox7b, in HEK (human embryonic kidney)-293 ..
  4. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
    ..decreased the expression levels of IL (interleukin)-1β, IL-6, HMGB-1 (high -mobility group box 1), and COX-2 (cyclooxygenase-2) by activating FXR and FOXO3a (forkhead box O3) against inflammation...
  5. Rueda E, Johnson J, Giddabasappa A, Swaroop A, Brooks M, Sigel I, et al. The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. Mol Vis. 2016;22:847-85 pubmed
    ..Quantitative cytochrome oxidase (COX) and lactate dehydrogenase (LDH) activity was determined histochemically...
  6. Gao P, Yang B, Yu H, Meng R, Si J. Carvedilol alleviates the biliary cirrhosis through inhibiting the endoplasmic reticulum stress. Eur Rev Med Pharmacol Sci. 2017;21:5813-5820 pubmed publisher
    ..mRNA expression levels of pro-inflammatory factors, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), transforming growth factor ?-1 (TGF-?1), ?-SMA and collagen-1 were detected via reverse transcription-..
  7. Zhao X, Sun P, Li G, Yi R, Qian Y, Park K. Polyphenols in Kuding tea help prevent HCl/ethanol-induced gastric injury in mice. Food Funct. 2018;9:1713-1725 pubmed publisher
    ..nuclear factor ?-light-chain-enhancer of activated B cells (NF-?B), inducible NOS (iNOS), and cyclooxygenase-2 (COX-2) was weaker in the HKTP group than in the control group...
  8. Udina M, Navines R, Egmond E, Oriolo G, Langohr K, Gimenez D, et al. Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..A survival analysis was performed, and the Cox proportional hazards model was used for the multivariate analysis. The cumulative incidence of depression was 0...
  9. Liu Q, Zhang C, Li Q, Zhu Y, Zhang D, Zhao W, et al. [Analysis of prognosis and associated risk factors in pediatric idiopathic pulmonary arterial hypertension]. Zhonghua Er Ke Za Zhi. 2018;56:23-28 pubmed publisher
    ..Kaplan-Meier survival curve was used to assess the survival,and the COX risk regression model was used to analyze the prognostic risk factors...

More Information

Publications152 found, 100 shown here

  1. Yang X, Yuan L, Xiong C, Yin C, Ruan J. Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative. J Ethnopharmacol. 2014;157:105-13 pubmed publisher
    ..In addition, the relative inflammatory factors, cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 8 (IL-8) ..
  2. Xu B, Kong X, Xu R, Song Y, Liu L, Zhou Z, et al. Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. Medicine (Baltimore). 2017;96:e5862 pubmed publisher
    ..Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox proportional-hazard regression models, adjusting for age, sex, baseline folate, vitamin B12, blood pressure, body ..
  3. Lin C, Lee H, Lee M, Pan S, Ke C, Chiu A, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
    ..levels of TFAM; mtDNA-encoded NADH dehydrogenase subunit 1 (ND1), ND6 and cytochrome c oxidase subunit 2 (COX-2); nuclear DNA (nDNA)-encoded succinate dehydrogenase subunit A (SDHA); v-akt murine thymoma viral oncogene ..
  4. Wang X, Cheng Y, Xue H, Yue Y, Zhang W, Li X. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia. 2015;105:16-25 pubmed publisher
    ..Moreover, compared with the I/R group, fargesin increased COX release and the activities of some endogenous antioxidative enzymes including superoxide dismutase (SOD), catalase (..
  5. GÄ…dek Michalska A, Tadeusz J, Rachwalska P, Bugajski J. Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems. Pharmacol Rep. 2013;65:1655-62 pubmed
    ..In the central nervous system (CNS), prostaglandins (PG) generated by the cyclooxygenase (COX) enzyme are involved in the regulation of HPA axis activity...
  6. Kaur T, Borse V, Sheth S, Sheehan K, Ghosh S, Tupal S, et al. Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. J Neurosci. 2016;36:3962-77 pubmed publisher
    ..the expression of STAT1 target genes, such as TNF-?, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced cisplatin-mediated apoptosis...
  7. Hippisley Cox J, Coupland C. Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study. BMJ. 2017;358:j4208 pubmed publisher
    ..50 million patients in the validation cohort.Methods Cox proportional hazards models in the derivation cohort were used to derive separate risk equations in men and women ..
  8. Suo H, Zhao X, Qian Y, Sun P, Zhu K, Li J, et al. Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects. Nutrients. 2016;8:155 pubmed publisher
    ..endothelial nitric oxide synthase), Mn-SOD, Cu/Zn-SOD, CAT (catalase) mRNA or protein expressions and reduced the COX-2, NF-κB (nuclear factor kappaB), and iNOS (inducible nitric oxide synthase) expressions in gastric tissues ..
  9. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..The activities of superoxide dismutase (SOD), glutathoinine peroxidase (GPx) and cytochrome c oxidase (COX) and the ATP level were significantly reduced after CdCl2 exposure...
  10. Lin C, Liu L, Ou L, Pan S, Lin C, Wei Y. Role of mitochondrial function in the invasiveness of human colon cancer cells. Oncol Rep. 2018;39:316-330 pubmed publisher
    ..and mitochondrial DNA (mtDNA)-encoded NADH dehydrogenase subunit 6 (ND6) and cytochrome c oxidase subunit II (COX-II) and nuclear DNA-encoded NADH ubiquinone oxidoreductase subunit A9 (NDUFA9), iron-sulfur protein subunit B of ..
  11. Kandemir F, Yildirim S, Kucukler S, Caglayan C, Mahamadu A, Dortbudak M. Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney. Biomed Pharmacother. 2018;105:981-991 pubmed publisher
    ..prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2)...
  12. Bellaver B, Souza D, Souza D, Quincozes Santos A. Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain. Mol Neurobiol. 2017;54:2969-2985 pubmed publisher
    ..cytokine levels, such as TNF-?, IL-1?, IL-6, IL-18, and messenger RNA (mRNA) levels of cyclo-oxygenase 2 (COX-2)...
  13. Hwang J, Kumar V, Kang S, Jung H, Park Y. Effects of Flower Buds Extract of Tussilago farfara on Focal Cerebral Ischemia in Rats and Inflammatory Response in BV2 Microglia. Chin J Integr Med. 2018;: pubmed publisher
    ..Nitric oxide (NO) production was measured in culture medium by Griess assay. The expressions of iNOS, COX-2 and pro-inflammatory cytokines mRNA were analyzed by reverse transcription-polymerase chain reaction...
  14. Czekaj R, Majka J, Ptak Belowska A, Szlachcic A, Targosz A, Magierowska K, et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol. 2016;67:261-75 pubmed
    ..of mRNA for tumor necrosis factor-? (TNF-?), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in gastric mucosa was evaluated by reverse transcription polymerase chain reaction (RT-PCR)...
  15. Huang Y, Zhou J, Qu C, Dou Y, Huang Q, Lin Z, et al. Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-?B activation on dextran sulfate sodium-induced ulcerative colitis in mice. J Ethnopharmacol. 2017;198:389-398 pubmed publisher
    ..The mRNA expression of MPO, iNOS and COX-2 in colon tissues was detected by qRT-PCR...
  16. Martinez C, Piagette J, Escobar A, Martin A, Palacios R, Peçanha F, et al. Aluminum exposure at human dietary levels promotes vascular dysfunction and increases blood pressure in rats: A concerted action of NAD(P)H oxidase and COX-2. Toxicology. 2017;390:10-21 pubmed publisher
    ..channels blocker TEA, the NAD(P)H oxidase inhibitor apocynin, superoxide dismutase (SOD), the non-selective COX inhibitor indomethacin and the selective COX-2 inhibitor NS 398 were analyzed...
  17. Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
    ..IL-6, tumor necrosis factor (TNF)-?, HMGB1, high mobility group box 1 protein (HMGB1), cyclooxygenase-2 (COX-2), the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-TNF receptor?associated factor 6..
  18. Brzozowska I, Strzalka M, Drozdowicz D, Konturek S, Brzozowski T. Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. Curr Pharm Des. 2014;20:4807-15 pubmed
    ..in healing rate of gastric ulcers may involve the gastroprotective factors derived from the activation of PG/COX and NO/NOS systems as well as gastrin which also was shown to exhibit protective and trophic effects in the upper ..
  19. Taranu I, Gras M, Pistol G, Motiu M, Marin D, Lefter N, et al. ω-3 PUFA rich camelina oil by-products improve the systemic metabolism and spleen cell functions in fattening pigs. PLoS ONE. 2014;9:e110186 pubmed publisher
    ..tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interleukin (IL-8) and cyclooxigenase 2 (COX-2) in comparison with T1 diet. By contrast, T2 diet increased (P<0...
  20. Urrunaga N, Magder L, Weir M, Rockey D, Mindikoglu A. Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List. Dig Dis Sci. 2016;61:309-16 pubmed publisher
    ..were determined and the association between renal dysfunction and waiting list mortality was assessed using Cox proportional hazard regression analysis...
  21. Siddiqui F, Naqvi S, Abidi L, Faizi S, Lubna -, Avesi L, et al. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. J Ethnopharmacol. 2016;182:221-34 pubmed publisher
    ..Opuntiol (aglycone) emerged as a dual inhibitor of cyclooxygenase (COX) and lipooxygenase (LOX) pathways. It also suppressed ROS and cytokine levels...
  22. Nandi A, Wadhwani N, Joshi S. Altered metabolic homeostasis between vitamin D and long chain polyunsaturated fatty acids in preeclampsia. Med Hypotheses. 2017;100:31-36 pubmed publisher
    ..ROS) production which in turn leads to increased expression of phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2)...
  23. Wang S, Jing H, Yang H, Liu Z, Guo H, Chai L, et al. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson's disease. J Ethnopharmacol. 2015;164:247-55 pubmed publisher
    ..expression of some anti-inflammatory M2 microglia markers, including IL-10, IL-1 receptor antagonist (IL-1Ra) and Cox-2. But it could significantly inhibit LPS-induced granulocyte colony-stimulating factor (G-CSF) expression...
  24. Kalil R, Carpenter M, Ivanova A, Gravens Mueller L, John A, Weir M, et al. Impact of Hyperuricemia on Long-term Outcomes of Kidney Transplantation: Analysis of the FAVORIT Study. Am J Kidney Dis. 2017;70:762-769 pubmed publisher
    ..b>Cox proportional hazards models were fit to examine the association of uric acid concentration with study end points ..
  25. Bruder Nascimento T, Kennard S, Antonova G, Mintz J, Bence K, Belin de Chantemèle E. Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms. Clin Sci (Lond). 2016;130:881-93 pubmed publisher
    ..dismutases (SODs)] whereas it increased ROS-generating enzymes [NADPH oxidases (NOXs)] and cyclooxygenase-2 (COX-1) expression, in aorta...
  26. Gupta S, Malik A, Arukha A. Ovarian and oocyte targets for development of female contraceptives. Expert Opin Ther Targets. 2015;19:1433-46 pubmed publisher
    ..ovulation and endometrium receptivity targeting phosphodiesterase 3, angiopoietins, gonadotropin-releasing hormone, COX-2, progesterone/estrogen receptor and follicle-stimulating hormone receptor are presented...
  27. Cohen T, Asheld W, Germano J, Islam S, Patel D. A Comparative Study of Defibrillator Leads at a Large-Volume Implanting Hospital: Results From the Pacemaker and Implantable Defibrillator Leads Survival Study ("PAIDLESS"). J Invasive Cardiol. 2015;27:292-300 pubmed
    ..lead design elements were compared using methods that include Kaplan Meier analysis, univariate and multivariable Cox regression models...
  28. Peng H, Wu X, Zhao L, Feng Y. Dynamic analysis of phospholipid metabolism of mouse macrophages treated with common non-steroidal anti-inflammatory drugs. Mol Cell Biochem. 2016;411:161-71 pubmed publisher
    ..The analysis results show that in anti-inflammatory effects, non-steroidal anti-inflammatory drugs can inhibit COX, induce the cellular fatty acid desaturation and the changes of phospholipid components, stimulate free fatty acids,..
  29. Erqou S, Echouffo Tcheugui J, Kip K, Aiyer A, Reis S. Association of cumulative social risk with mortality and adverse cardiovascular disease outcomes. BMC Cardiovasc Disord. 2017;17:110 pubmed publisher
    ..Hazard ratios (HRs) were computed using Cox-regression models, adjusted for CVD risk factors. Over a median follow-up period of 8...
  30. Kono K, Nishida Y, Yabe H, Moriyama Y, Mori T, Shiraki R, et al. Development and validation of a Fall Risk Assessment Index for dialysis patients. Clin Exp Nephrol. 2018;22:167-172 pubmed publisher
    ..The Cox proportional hazards analysis evaluated the impact of falls...
  31. Nagy B, Tóth L, Molnár P, Méhes G, Thurzó L, Póka R, et al. Nuclear β-catenin positivity as a predictive marker of long-term survival in advanced epithelial ovarian cancer. Pathol Res Pract. 2017;213:915-921 pubmed publisher
    ..Statistical evaluation of the data included Kaplan-Meier analysis, the log-rank test and Cox proportional hazards model...
  32. Schroeder J, Hamada S, Gründlinger N, Rubeau T, Altiok E, Ulbrich K, et al. Myocardial deformation by strain echocardiography identifies patients with acute coronary syndrome and non-diagnostic ECG presenting in a chest pain unit: a prospective study of diagnostic accuracy. Clin Res Cardiol. 2016;105:248-56 pubmed publisher
    ..The incremental value of LVEF, WMSI, and strain parameters to relevant clinical variables was determined in nested Cox models. Baseline clinical data associated with relevant CAD were age [hazard ratio (HR) 1.31, p = 0...
  33. Watts J. Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids. J Clin Med. 2016;5: pubmed publisher
    ..Recent findings with importance to human health include the identification of a conserved Cox-independent prostaglandin synthesis pathway, critical functions for cytochrome P450 derivatives of polyunsaturated ..
  34. Laurin L, Gasim A, Poulton C, Hogan S, Jennette J, Falk R, et al. Treatment with Glucocorticoids or Calcineurin Inhibitors in Primary FSGS. Clin J Am Soc Nephrol. 2016;11:386-94 pubmed publisher
    ..Factors associated with initiation of therapy were identified using logistic regression. Time-dependent Cox models were performed to compare time to ESRD between different therapies...
  35. Retamozo S, Gheitasi H, Quartuccio L, Kostov B, Corazza L, Bove A, et al. Cryoglobulinaemic vasculitis at diagnosis predicts mortality in primary Sjögren syndrome: analysis of 515 patients. Rheumatology (Oxford). 2016;55:1443-51 pubmed publisher
    ..criteria and serum cryoglobulins at diagnosis were assessed as predictors of death and lymphoma using Cox proportional-hazards regression analysis adjusted for age and gender...
  36. Liu B, Yan S, Qu L, Zhu J. Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. Cancer Cell Int. 2017;17:1 pubmed publisher
    b>COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma...
  37. Yao H, Wang B, Wu Y, Huang Q. High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer. Med Sci Monit. 2017;23:1286-1294 pubmed
    ..000). The Cox model analysis demonstrated that expression of AGGF1 was an independent biomarker for prediction of patients' ..
  38. Bonilla Palomas J, Gámez López A, Moreno Conde M, López Ibáñez M, Castellano García P, Ráez Ruiz C, et al. [Impact of malnutrition on long-term mortality in outpatients with chronic heart failure]. Nutr Hosp. 2017;34:1382-1389 pubmed publisher
    ..Their possible independent association with mortality was analyzed by Cox multivariate analysis. The mean age was 74.6 ± 10.1 years, 41...
  39. Costanzo S, De Curtis A, Di Castelnuovo A, Persichillo M, Bonaccio M, Pounis G, et al. Serum vitamin D deficiency and risk of hospitalization for heart failure: Prospective results from the Moli-sani study. Nutr Metab Cardiovasc Dis. 2018;28:298-307 pubmed publisher
    ..Hazard ratios (HRs) were calculated using Cox-proportional hazard models. The prevalence of normal, insufficient or deficient levels of Vitamin D was 12.2%, 79...
  40. Dierssen Sotos T, Gomez Acebo I, de Pedro M, Perez Gomez B, Servitja S, Moreno V, et al. Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study. BMC Cancer. 2016;16:660 pubmed publisher
    ..The COX-2 selectivity showed an inverse association with breast cancer (i.e...
  41. Tembhekar A, Wright C, Daly M. Cardiac Dose and Survival After Stereotactic Body Radiotherapy for Early-stage Non-Small-cell Lung Cancer. Clin Lung Cancer. 2017;18:293-298 pubmed publisher
    ..The DVH parameters were assessed as predictors of OS using Cox regression analysis. We identified 102 patients with 118 treated tumors. At a median follow-up period of 27...
  42. Thomas X, De Botton S, Chevret S, Caillot D, Raffoux E, Lemasle E, et al. Randomized Phase II Study of Clofarabine-Based Consolidation for Younger Adults With Acute Myeloid Leukemia in First Remission. J Clin Oncol. 2017;35:1223-1230 pubmed publisher
    ..Overall, 110 patients (55 in each arm) received SCT in first remission. On the basis of a multivariable Cox-adjusted treatment × SCT interaction, the HR of CLARA over HDAC before or in absence of SCT was 0.65 (95% CI, 0...
  43. Xu X, Wang J, Yang R, Dong Z, Zhang D. Genetic or pharmacologic inhibition of EGFR ameliorates sepsis-induced AKI. Oncotarget. 2017;8:91577-91592 pubmed publisher
    ..selective EGFR inhibitor, abrogated LPS-induced phosphorylation of EGFR, ERK1/2, and STAT3 as well as expression of COX, eNOS, and proinflammatory cytokines in HK-2 cells...
  44. Wallman J, Kapetanovic M, Petersson I, Geborek P, Kristensen L. Comparison of non-radiographic axial spondyloarthritis and ankylosing spondylitis patients--baseline characteristics, treatment adherence, and development of clinical variables during three years of anti-TNF therapy in clinical practice. Arthritis Res Ther. 2015;17:378 pubmed publisher
    ..Anti-TNF adherence was compared by Log rank test and Cox regression...
  45. Hsu P, Pan W, Yip B, Chen R, Cheng H, Chuang S. C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort. J Am Med Dir Assoc. 2017;18:277.e7-277.e11 pubmed publisher
    ..Baseline characteristics and CRP levels were determined. A Cox proportional hazard model and Fine and Grays model were adjusted for stroke and competing risk of death to estimate ..
  46. Inoue K, Suna S, Iwakura K, Oka T, Masuda M, Furukawa Y, et al. Outcomes for Atrial Fibrillation Patients with Silent Left Atrial Thrombi Detected by Transesophageal Echocardiography. Am J Cardiol. 2017;120:940-946 pubmed publisher
    ..Multivariate Cox regression analysis showed the composite end point of death, stroke, systemic embolism, and major bleeding was ..
  47. Tang T, Wu L, Yang L, Jiang J, Hao Q, Dong B, et al. A sarcopenia screening test predicts mortality in hospitalized older adults. Sci Rep. 2018;8:2923 pubmed publisher
    ..Survival status was assessed at 12, 24, and 36 months after the baseline investigation. Cox proportional-hazard models were applied to calculate the hazard ratio for mortality associated with sarcopenia...
  48. Trestini I, Carbognin L, Sperduti I, Bonaiuto C, Auriemma A, Melisi D, et al. Prognostic impact of early nutritional support in patients affected by locally advanced and metastatic pancreatic ductal adenocarcinoma undergoing chemotherapy. Eur J Clin Nutr. 2018;72:772-779 pubmed publisher
    ..Clinical-pathological and nutritional data were correlated with overall survival (OS) using a Cox model...
  49. Giurdanella G, Anfuso C, Olivieri M, Lupo G, Caporarello N, Eandi C, et al. Aflibercept, bevacizumab and ranibizumab prevent glucose-induced damage in human retinal pericytes in vitro, through a PLA2/COX-2/VEGF-A pathway. Biochem Pharmacol. 2015;96:278-87 pubmed publisher
    ..endothelial cells, via VEGF induction, which may be counteracted by anti-VEGFs and (ii) activation of PLA2/COX-2 pathway by high glucose might be upstream and/or downstream of VEGF in perycites, as previously observed in ..
  50. Fretts A, Mozaffarian D, Siscovick D, King I, McKnight B, Psaty B, et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. J Nutr. 2016;146:298-305 pubmed publisher
    ..stearic acid (18:0), arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) were assessed using Cox proportional hazards models. During 45,450 person-years of follow-up, 3134 deaths occurred...
  51. Pazik J, Lewandowski Z, Oldak M, Oziębło D, Perkowska Ptasinska A, Sadowska A, et al. Association of MYH9 rs3752462 and rs5756168 Polymorphisms With Transplanted Kidney Artery Stenosis. Transplant Proc. 2016;48:1561-5 pubmed publisher
    ..Statistical analysis was performed with the use of Kaplan-Meier estimates, log-rank tests, and proportional hazard Cox models. Recipients carrying TT in rs5756168 experienced diminished risk of TRAS (hazard ratio [HR], 0.31; P < ...
  52. Deng Y, Chen G, Zhu W, Rui H, Hong H, Chen J. [Expression and Prognostic Significance of H3K27 Trimethylation Protein in DLBCL]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1379-1385 pubmed publisher
    ..Survival rates were analyzed by the Kaplan-Meier method, and prognostic factor were analyzed by the Cox proportional hazards model, the relation of different expression levels with clinical feature and prognosis of ..
  53. Chan S, Rowbottom L, McDonald R, Zhang L, Bjarnason G, Tsao M, et al. Could time of whole brain radiotherapy delivery impact overall survival in patients with multiple brain metastases?. Ann Palliat Med. 2016;5:267-279 pubmed publisher
    ..Kaplan-Meier curves were created for OS. Univariate and multivariate Cox proportional hazard (PH) model were used to find predictive factors of OS in all patients, females and males...
  54. Notaras A, Demetriou E, Galvin J, Ben Menachem E. A cross-sectional study of preoperative medication adherence and early postoperative recovery. J Clin Anesth. 2016;35:129-135 pubmed publisher
    ..test; continuous parametric data were compared using a time to survival analysis via Kaplan-Meier estimates and Cox proportional hazard regressions to account for possible confounders...
  55. Ozden C, Aktas B, Bulut S, Erbay G, Tagci S, Gokkaya C, et al. Effect of age on biochemical recurrence after radical prostatectomy. Kaohsiung J Med Sci. 2017;33:91-95 pubmed publisher
    ..Factors associated with BCR in multivariate Cox regression analysis were ECE, seminal vesicle invasion, positive surgical margin, and RRP specimens' Gleason score ..
  56. Bitto A, Giuliani D, Pallio G, Irrera N, Vandini E, Canalini F, et al. Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice. Inflamm Res. 2017;66:389-398 pubmed publisher
    ..We investigated the possible neuroprotective role of flavocoxid, a dual inhibitor of cyclooxygenases-1/2 (COX-1/2) and 5-Lipoxygenase (5-LOX), in triple-transgenic (3xTg-AD) mice...
  57. Magvanjav O, McDonough C, Gong Y, McClure L, Talbert R, Horenstein R, et al. Pharmacogenetic Associations of β1-Adrenergic Receptor Polymorphisms With Cardiovascular Outcomes in the SPS3 Trial (Secondary Prevention of Small Subcortical Strokes). Stroke. 2017;48:1337-1343 pubmed publisher
    ..MACE included stroke, myocardial infarction, and all-cause death. Kaplan-Meier and multivariable Cox regression analyses were used...
  58. Al Kawaz M, Omran S, Parikh N, Elkind M, Soliman E, Kamel H. Comparative Risks of Ischemic Stroke in Atrial Flutter versus Atrial Fibrillation. J Stroke Cerebrovasc Dis. 2018;27:839-844 pubmed publisher
    ..b>Cox proportional hazards analysis was used to compare the associations of flutter and fibrillation with ischemic stroke ..
  59. Piotrowski W, Waśkiewicz A, Cicha Mikołajczyk A. Global cardiovascular mortality risk in the adult Polish population: prospective assessment of the cohorts studied in multicentre national WOBASZ and WOBASZ Senior studies. Kardiol Pol. 2016;74:262-73 pubmed publisher
    ..Statistical methods included descriptive statistics, Kaplan-Meier curves, Cox proportional hazard models, and the SCORE risk algorithm...
  60. Scarpelli R, Sasso O, Piomelli D. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem. 2016;11:1242-51 pubmed publisher
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit the cyclooxygenase (COX)-mediated production of pain- and inflammation-inducing prostanoids, are a common first-line treatment for this ..
  61. Gao N, Zhai Q, Li Y, Huang K, Bian D, Wang X, et al. Clinical Implications of TβRII Expression in Breast Cancer. PLoS ONE. 2015;10:e0141412 pubmed publisher
    ..006, P = 0.016, P = 0.022, and P = 0.033, respectively). Cox regression analysis revealed that high TβRII expression was related to poor 5-year DFS, and it was an ..
  62. Peschken C, Hitchon C, Garland A, Bernstein C, Chen H, Fransoo R, et al. A Population-based Study of Intensive Care Unit Admissions in Rheumatoid Arthritis. J Rheumatol. 2016;43:26-33 pubmed publisher
    ..mortality after ICU admission were compared between populations using age- and sex-standardized rates, rate ratios, Cox proportional hazards models, and logistic regression models...
  63. Qu J, Xi J, Zhang Y, ZHANG C, Song L, Song Y, et al. Association of the MicroRNA-146a SNP rs2910164 with Ischemic Stroke Incidence and Prognosis in a Chinese Population. Int J Mol Sci. 2016;17: pubmed publisher
    ..31-3.46; p = 0.002). The independent association of rs2910164 with stroke prognosis was evaluated using Cox regression models...
  64. Gao H, Yang J, Chen Z, Zhang X, Yan H, Guo W, et al. Plasma dynamic monitoring of soluble c-Met level for EGFR-TKI treatment in advanced non-small cell lung cancer. Oncotarget. 2016;7:39535-39543 pubmed publisher
    ..2 vs. 14.0 months; P = 0.003) after EGFR-TKI treatment. Multivariate Cox proportional hazards model analyses demonstrated that the soluble c-Met level was an independent prognostic factor ..
  65. Gerbing R, Alonzo T, Sung L, Gamis A, Meshinchi S, Plon S, et al. Shorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children's Oncology Group. J Clin Oncol. 2016;: pubmed
    ..001) and fifth chemotherapy courses (P = .002). Cox regression adjusting for age at diagnosis confirmed that TC remained independently predictive of time to recovery ..
  66. Qiu H, Sun S, Tsang H, Wong C, Lee R, Schooling C, et al. Fine particulate matter exposure and incidence of stroke: A cohort study in Hong Kong. Neurology. 2017;88:1709-1717 pubmed publisher
    ..Baseline residential PM2.5 exposure was used as a proxy for long-term exposure. We used Cox proportional hazards to evaluate the risk of incident stroke associated with PM2...
  67. Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, et al. Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-?B/COX-2 signaling pathway by targeting IKK?. Am J Cancer Res. 2017;7:1270-1284 pubmed
    ..Furthermore, our results fully demonstrate that DHE significantly suppressed COX-2 expression by inhibiting the phosphorylation of IKK? via targeting the ATP-binding site, thereby abrogating NF-?B ..
  68. Zahran M, Eldemerdash Y, Taha D, Sheir K, Shaaban A, Ali el Dein B. Chronic urinary retention after radical cystectomy and orthotopic neobladder in women: Risk factors and relation to time. Urol Oncol. 2017;35:671.e11-671.e16 pubmed publisher
    ..for the cumulative incidence of CUR using Kaplan-Meier curve and for the possible risk factors using log rank and Cox regression analysis. A total of 234 women with mean age ± SD of 52...
  69. Liu X, Mangla R, Tian W, Qiu X, Li D, Walter K, et al. The preliminary radiogenomics association between MR perfusion imaging parameters and genomic biomarkers, and their predictive performance of overall survival in patients with glioblastoma. J Neurooncol. 2017;135:553-560 pubmed publisher
    ..29 and 1.063 respectively) by Cox regression analysis...
  70. Vargo J, Gill B, Balasubramani G, Beriwal S. Treatment Selection and Survival Outcomes in Early-Stage Diffuse Large B-Cell Lymphoma: Do We Still Need Consolidative Radiotherapy?. J Clin Oncol. 2015;33:3710-7 pubmed publisher
    ..Propensity-adjusted Cox proportional hazard ratios for survival were used to account for indication bias...
  71. Schneider J, Sick B, Luft A, Wegener S. Ultrasound and Clinical Predictors of Recurrent Ischemia in Symptomatic Internal Carotid Artery Occlusion. Stroke. 2015;46:3274-6 pubmed publisher
    ..Predictors for recurrent ipsilateral ischemia were investigated by Cox regression analysis...
  72. Devereux R, Bang C, Roman M, Palmieri V, Boman K, Gerdts E, et al. Left Ventricular Wall Stress-Mass-Heart Rate Product and Cardiovascular Events in Treated Hypertensive Patients: LIFE Study. Hypertension. 2015;66:945-53 pubmed publisher
    ..The triple product was included as time-varying covariate in Cox models assessing predictors of the LIFE primary composite end point (cardiovascular death, MI, or stroke), its ..
  73. Lee B, Toh S, Ryan S, Simpson J, Clezy K, Bossa L, et al. Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial. BMC Urol. 2016;16:18 pubmed publisher
    ..The primary outcome will be analysed using survival analysis of factorial groups, with Cox regression modelling to test the effect of each treatment while allowing for the other, assuming no interaction ..
  74. Toledo Alvarado H, Cecchinato A, Bittante G. Fertility traits of Holstein, Brown Swiss, Simmental, and Alpine Grey cows are differently affected by herd productivity and milk yield of individual cows. J Dairy Sci. 2017;100:8220-8231 pubmed publisher
    ..calving to first service, interval from first service to conception, and number of days open were analyzed using a Cox's proportional hazards model...
  75. Kim J, Kim M, Ju Y, Hwang S, Ha M, Kim B, et al. Reanalysis of Epidemiological Investigation of Cancer Risk among People Residing near Nuclear Power Plants in South Korea. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..i>Methods: In addition to replicating the original Cox proportional hazards models, nested case-control analysis was carried out for all subjects and for four different ..
  76. Winn A, Shah G, Cohen J, Lin P, Parsons S. The real world effectiveness of hematopoietic transplant among elderly individuals with multiple myeloma. J Natl Cancer Inst. 2015;107: pubmed publisher
    ..Survival was measured by Cox proportional hazard models. All statistical tests were two-sided...
  77. Wu I, Chen H, Bordnick P, Essien E, Johnson M, Peters R, et al. Comparison of Suicide Attempts/Behaviors Following Smoking Cessation Treatments Among Schizophrenic Smokers. Arch Psychiatr Nurs. 2017;31:62-67 pubmed publisher
    ..Patients' suicide behaviors or attempts were identified through ICD-9 codes and E-codes. Cox proportional hazards model was applied to examine the association between smoking cessation medication and suicidal/..
  78. Slattery P, Frölich S, Goren I, Nusing R. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. Am J Physiol Renal Physiol. 2017;312:F1044-F1055 pubmed publisher
    Deficiency of cyclooxygenase-2 (COX-2) activity in the early postnatal period causes impairment of kidney development leading to kidney insufficiency...
  79. Hofer M, Hoferova Z, Dusek L, Soucek K, Gruzdev A. Hematological profile of untreated or ionizing radiation-exposed cyclooxygenase-2-deficient mice. Physiol Res. 2017;66:673-676 pubmed
    We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice...
  80. Ali M, Hirshman B, Wilson B, Carroll K, Proudfoot J, Goetsch S, et al. Survival Patterns of 5750 Stereotactic Radiosurgery-Treated Patients with Brain Metastasis as a Function of the Number of Lesions. World Neurosurg. 2017;107:944-951.e1 pubmed publisher
    ..Survival analyses were performed with Kaplan-Meier analysis as well as univariate and multivariate Cox proportional hazards models...
  81. Yang C, Gu L, Shah S, Yerokun B, D Amico T, Hartwig M, et al. Long-term outcomes of surgical resection for stage IV non-small-cell lung cancer: A national analysis. Lung Cancer. 2018;115:75-83 pubmed publisher
    ..NSCLC patients treated with surgery in the National Cancer Date Base (2004-2013) were evaluated using multivariable Cox proportional hazards analyses...
  82. Hörder H, Johansson L, Guo X, Grimby G, Kern S, Östling S, et al. Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women. Neurology. 2018;90:e1298-e1305 pubmed publisher
    ..b>Cox regressions were performed with adjustment for socioeconomic, lifestyle, and medical confounders...
  83. Meyer P, de Oliveira P, Silva F, da Costa A, Pereira C, Casenave S, et al. Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue. Lasers Med Sci. 2017;32:1727-1736 pubmed publisher
    ..In addition, FGF2, CD105, and COX-2 expression was assessed by immunohistochemical staining...
  84. Solbak N, Xu J, Vena J, Csizmadi I, Whelan H, Robson P. Diet quality is associated with reduced incidence of cancer and self-reported chronic disease: Observations from Alberta's Tomorrow Project. Prev Med. 2017;101:178-187 pubmed publisher
    ..Participants were divided into HEI-2005-Canada score quartiles. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for cancer ..
  85. Li G, Xia M, Abais J, Boini K, Li P, Ritter J. Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes. J Pharmacol Exp Ther. 2016;358:61-70 pubmed publisher
    ..These effects of AEA were inhibited by the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CEL)...
  86. Lu J, Shao R, Jin S, Hu L, Tu Y, Guo J. Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression. Brain Res Bull. 2017;128:106-112 pubmed publisher
    ..NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) were determined in the rat hippocampus and prefrontal cortex...
  87. Fusar Poli P, Palombini E, Davies C, Oliver D, Bonoldi I, Ramella Cravaro V, et al. Why transition risk to psychosis is not declining at the OASIS ultra high risk service: The hidden role of stable pretest risk enrichment. Schizophr Res. 2018;192:385-390 pubmed publisher
    ..of psychosis were stratified and compared across three time periods (2001-2005, 2006-2010, 2011-2015) with Cox analysis and modulating factors were investigated...
  88. Sohilait M, Pranowo H, Haryadi W. Molecular docking analysis of curcumin analogues with COX-2. Bioinformation. 2017;13:356-359 pubmed publisher
    Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully...
  89. Mohd Aluwi M, Rullah K, Yamin B, Leong S, Abdul Bahari M, Lim S, et al. Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorg Med Chem Lett. 2016;26:2531-2538 pubmed publisher
    ..Further experiment showed that compounds 8b, 8c, 15a and 15b did not target the activity of downstream inflammatory COX-2 mediator...
  90. Iaboni A, Rawson K, Burkett C, Lenze E, Flint A. Potentially Inappropriate Medications and the Time to Full Functional Recovery After Hip Fracture. Drugs Aging. 2017;34:723-728 pubmed publisher
    ..b>Cox proportional hazards models examined the time to 95% recovery of function ('full recovery'), adjusting for ..
  91. Park E, Lee M, Seo C, Jeon W, Shin H. Yongdamsagan-tang, a traditional herbal formula, inhibits cell growth through the suppression of proliferation and inflammation in benign prostatic hyperplasia epithelial-1 cells. J Ethnopharmacol. 2017;209:230-235 pubmed publisher
    ..Furthermore, YSTE treatment in BPH-1 cells suppressed prostaglandin E2 production and cyclooxygenase-2 (COX-2) protein levels...
  92. Gul I, Yucel O, Zararsiz A, Demirpence O, Yucel H, Zorlu A, et al. Prognostic role of soluble suppression of tumorigenicity-2 on cardiovascular mortality in outpatients with heart failure. Anatol J Cardiol. 2017;18:200-205 pubmed publisher
    ..In multiple Cox regression analysis, sST2 level of >30 ng/mL (HR=6.756, p=0.002, 95% CI=1.983-23.018), hemoglobin level (HR=0...