COX-2

Summary

Gene Symbol: COX-2
Description: cytochrome c oxidase subunit II
Alias: COII, MTCO2
Species: human
Products:     COX-2

Top Publications

  1. Stiburek L, Vesela K, Hansikova H, Hulkova H, Zeman J. Loss of function of Sco1 and its interaction with cytochrome c oxidase. Am J Physiol Cell Physiol. 2009;296:C1218-26 pubmed publisher
    ....
  2. Quaranta M, Vincentini O, Felli C, Spadaro F, Silano M, Moricoli D, et al. Exogenous HIV-1 Nef upsets the IFN-γ-induced impairment of human intestinal epithelial integrity. PLoS ONE. 2011;6:e23442 pubmed publisher
    ..Our results may improve the understanding of AIDS pathogenesis, supporting the discovery of new therapeutic interventions. ..
  3. Hao W, Miles T, Martin F, Browne G, Förster H, Adaskaveg J. Temporal occurrence and niche preferences of Phytophthora species causing brown rot of citrus in the Central Valley of California. Phytopathology. 2017;: pubmed publisher
    ..In contrast, P. citrophthora, was rarely found in leaf litter, but was commonly detected in the rhizosphere. Thus, leaf litter is a major inoculum source for P. syringae and this species occupies a distinct ecological niche...
  4. Xu H, Lin F, Wang Z, Yang L, Meng J, Ou Z, et al. CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. Cancer Lett. 2018;412:69-80 pubmed publisher
    ..Thus, antagonists of the CXCR2 signaling molecules may be used to treat breast cancer patients particularly with high metastasis and chemoresistance...
  5. Na Phatthalung P, Teles M, Voravuthikunchai S, Tort L, Fierro Castro C. Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss). Fish Physiol Biochem. 2017;: pubmed publisher
    ....
  6. Yu Y, Gong R, Mu Y, Chen Y, Zhu C, Sun Z, et al. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. J Immunol. 2011;187:4844-60 pubmed publisher
    ..These new findings provide insights for our understanding of the mechanism by which inflammatory factors regulate each other in response to HBV infection. ..
  7. Loo T, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, et al. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov. 2017;7:522-538 pubmed publisher
    ..i>Cancer Discov; 7(5); 522-38. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 443. ..
  8. Alves M, Ferrasi A, Lima V, Ferreira M, De Moura Campos Pardini M, Rabenhorst S. Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype. Pathobiology. 2011;78:266-76 pubmed publisher
    ..These data suggest that the inactivation of these genes by methylation occurs by distinct pathways according to the histological subtype and tumor location and depends on the H. pylori genotype. ..
  9. Almeida M, Munoz J, Nunes S, Fonseca Moutinho J. Cyclooxygenase-2 immunoexpression in breast cancer: progesterone receptor influence. Cancer Epidemiol. 2011;35:e81-4 pubmed publisher
    ..These results suggest that progesterone receptor has a protective role in breast cancer by inhibiting chronic inflammatory pathway. ..
  10. Qi W, Tian Z, Lu L, Chen X, Chen X, Zhang W, et al. Editing of Mitochondrial Transcripts nad3 and cox2 by Dek10 Is Essential for Mitochondrial Function and Maize Plant Development. Genetics. 2017;205:1489-1501 pubmed publisher
    ..These results indicate that the E-subgroup PPR protein Dek10 is responsible for multiple editing sites in nad3 and cox2, which are essential for mitochondrial functions and plant development in maize. ..

Detail Information

Publications62

  1. Stiburek L, Vesela K, Hansikova H, Hulkova H, Zeman J. Loss of function of Sco1 and its interaction with cytochrome c oxidase. Am J Physiol Cell Physiol. 2009;296:C1218-26 pubmed publisher
    ....
  2. Quaranta M, Vincentini O, Felli C, Spadaro F, Silano M, Moricoli D, et al. Exogenous HIV-1 Nef upsets the IFN-γ-induced impairment of human intestinal epithelial integrity. PLoS ONE. 2011;6:e23442 pubmed publisher
    ..Our results may improve the understanding of AIDS pathogenesis, supporting the discovery of new therapeutic interventions. ..
  3. Hao W, Miles T, Martin F, Browne G, Förster H, Adaskaveg J. Temporal occurrence and niche preferences of Phytophthora species causing brown rot of citrus in the Central Valley of California. Phytopathology. 2017;: pubmed publisher
    ..In contrast, P. citrophthora, was rarely found in leaf litter, but was commonly detected in the rhizosphere. Thus, leaf litter is a major inoculum source for P. syringae and this species occupies a distinct ecological niche...
  4. Xu H, Lin F, Wang Z, Yang L, Meng J, Ou Z, et al. CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. Cancer Lett. 2018;412:69-80 pubmed publisher
    ..Thus, antagonists of the CXCR2 signaling molecules may be used to treat breast cancer patients particularly with high metastasis and chemoresistance...
  5. Na Phatthalung P, Teles M, Voravuthikunchai S, Tort L, Fierro Castro C. Immunomodulatory effects of Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss). Fish Physiol Biochem. 2017;: pubmed publisher
    ....
  6. Yu Y, Gong R, Mu Y, Chen Y, Zhu C, Sun Z, et al. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. J Immunol. 2011;187:4844-60 pubmed publisher
    ..These new findings provide insights for our understanding of the mechanism by which inflammatory factors regulate each other in response to HBV infection. ..
  7. Loo T, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, et al. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity. Cancer Discov. 2017;7:522-538 pubmed publisher
    ..i>Cancer Discov; 7(5); 522-38. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 443. ..
  8. Alves M, Ferrasi A, Lima V, Ferreira M, De Moura Campos Pardini M, Rabenhorst S. Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype. Pathobiology. 2011;78:266-76 pubmed publisher
    ..These data suggest that the inactivation of these genes by methylation occurs by distinct pathways according to the histological subtype and tumor location and depends on the H. pylori genotype. ..
  9. Almeida M, Munoz J, Nunes S, Fonseca Moutinho J. Cyclooxygenase-2 immunoexpression in breast cancer: progesterone receptor influence. Cancer Epidemiol. 2011;35:e81-4 pubmed publisher
    ..These results suggest that progesterone receptor has a protective role in breast cancer by inhibiting chronic inflammatory pathway. ..
  10. Qi W, Tian Z, Lu L, Chen X, Chen X, Zhang W, et al. Editing of Mitochondrial Transcripts nad3 and cox2 by Dek10 Is Essential for Mitochondrial Function and Maize Plant Development. Genetics. 2017;205:1489-1501 pubmed publisher
    ..These results indicate that the E-subgroup PPR protein Dek10 is responsible for multiple editing sites in nad3 and cox2, which are essential for mitochondrial functions and plant development in maize. ..
  11. Wang Y, Wu M, Yang A, Zhang W, Sun J, Liu T, et al. COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. Med Oncol. 2011;28 Suppl 1:S360-6 pubmed publisher
    ..Our results suggested that COX-2 played essential roles in the proliferation and metastasis of tongue cancer, and COX-2 could serve as a potential chemotherapy target for tongue cancer...
  12. Tripathy M, Mitra D. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications. Apoptosis. 2010;15:28-40 pubmed publisher
    ..This differential regulation in activities of OXPHOS system complexes indicate a complex modulation of host cell energy generating system during HIV infection that ultimately leads to T cell apoptosis. ..
  13. Lamb T, Marais E, Bond J. A second locality for the Namib darkling beetle Onymacris brainei (Tenebrionidae, Coleoptera) and first report on its molecular phylogenetic placement. Zookeys. 2017;:63-72 pubmed publisher
    ..The paraphyly of Onymacris with respect to Physadesmia highlights a need for nomenclatural change, but revision should await acquisition of genetic data for the few species outstanding in both genera...
  14. Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, et al. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 2017;284:37-45 pubmed publisher
    ..We also suggest that the patients with renal injury can take more Shanyao for the therapy and treatment. ..
  15. Chowdhury M, Choi B, Khan I, Lee K, Mesalam A, Song S, et al. Supplementation of lycopene in maturation media improves bovine embryo quality in vitro. Theriogenology. 2017;103:173-184 pubmed publisher
    ..05) higher in the 0.2 μM lycopene-supplemented group than the control. In conclusion, lycopene improves blastocyst quality by overcoming unfavorable conditions in in vitro culture systems. ..
  16. Covarrubias S, Robinson E, Shapleigh B, Vollmers A, Katzman S, Hanley N, et al. CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-κB reporter. J Biol Chem. 2017;292:20911-20920 pubmed publisher
    ....
  17. Harting M, Srivastava A, Zhaorigetu S, Bair H, Prabhakara K, Toledano Furman N, et al. Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation. Stem Cells. 2017;: pubmed publisher
    ..The present study demonstrates that inflammatory stimulation of MSCs renders release of EVs that have enhanced anti-inflammatory properties partially due to COX2/PGE2 pathway alteration. Stem Cells 2017...
  18. Yu J, Nam B, Yoon J, Kim E, Park J, Kim H, et al. Tracing the spatio-temporal dynamics of endangered fin whales (Balaenoptera physalus) within baleen whale (Mysticeti) lineages: a mitogenomic perspective. Genetica. 2017;145:603-612 pubmed publisher
    ..Interestingly, fin whales have 16 species-specific amino acid residues in eight mitochondrial genes: NADH2, COX2, COX3, ATPase6, ATPase8, NADH4, NADH5, and Cytb. ..
  19. Worasilchai N, Permpalung N, Chindamporn A. High-resolution melting analysis: A novel approach for clade differentiation in Pythium insidiosum and pythiosis. Med Mycol. 2017;: pubmed publisher
    ..In conclusion, the qPCR-HRM is a simple one closed tube, inexpensive and user-friendly method to identify P. insidiosum into clade level...
  20. Kato M. The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. Leuk Lymphoma. 1999;33:181-6 pubmed
    ..These two new pathways, p53-EF-1 alpha-microtubule-severing (-distortion of cytoskeleton) and p53-cyclin G1-COXII (-CytC, ATP-caspase-3 activation), may cooperate to induce apoptosis in this cell line. ..
  21. Qin Y, Li M, Feng X, Wang J, Cao L, Shen X, et al. Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke. Free Radic Biol Med. 2017;104:333-345 pubmed publisher
    ..These studies suggest that, beyond anti-oxidative effects, NADPH may also have anti-inflammatory effects and combination of NADPH and NOX inhibitors could produce a greater neuroprotective effect in ischemic stroke. ..
  22. Xu F, Li M, Zhang C, Cui J, Liu J, Li J, et al. Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. Oncotarget. 2017;8:6003-6012 pubmed publisher
    ..51, 95% CI [1.31, 1.72]). Our meta-analysis demonstrates that the presence of high levels of COX-2 is associated with poor prognosis for breast cancer patients and predicts bigger tumor size and lymph node metastasis. ..
  23. Kim J, Vaish V, Feng M, Field K, Chatzistamou I, Shim M. Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice. Aging (Albany NY). 2016;8:2392-2406 pubmed publisher
    ..Our study reveals that the increased COX2 expression has an impact on the aging process and suggests that modulation of COX2 and its downstream signaling may be an approach for intervention of age-related disorders. ..
  24. Cha J, Li S, Cha I. Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. Head Neck. 2011;33:627-37 pubmed publisher
    ..Our results indicate that the cytoplasmic expression of HuR is associated with COX-2 expression in OSCCs and HuR can regulate COX-2 expression in oral cancer cell lines. ..
  25. Sandeep Varma R, Ashok G, Vidyashankar S, Nandakumar K, Patki P. Bresol inhibits phosphodiesterase 4 gene expression and modulates the levels of select mediators of inflammation in human monocytic cells. J Immunotoxicol. 2011;8:315-23 pubmed publisher
    ..The anti-inflammatory effects of bresol might also be a result of the capacity of bresol to modulate the formation of TNFα, NO, and COX-2 in monocytes. ..
  26. Hornig Do H, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rotig A, et al. Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly. EMBO J. 2012;31:1293-307 pubmed publisher
    ..Our data indicate that the mechanism underlying pathogenesis in these patients is the rapid clearance of unstable respiratory complexes by quality control pathways, rather than their impaired assembly. ..
  27. Zhang Z, Zheng F, Yu Z, Hao J, Chen M, Yu W, et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. PLoS ONE. 2017;12:e0186900 pubmed publisher
    ....
  28. Huo X, Gao Y, Ma Q. [Effect of L-arginine on human colon carcinoma cell line LS174 through NO pathway and the mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:70-5 pubmed
    ..The mechanism of L-Arg- induced cell apoptosis may be related to the up-regulation of bax protein and the down-regulation of p53 and bcl-2 proteins. ..
  29. Yang J, Li Y, Hylemon P, Zhang L, Zhou H. Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation. Biomed Pharmacother. 2017;95:1777-1788 pubmed publisher
    ....
  30. Hsu S, Lee J, Lin T, Hsieh Y, Huang H, Lee F, et al. The beneficial effects of curcumin in cirrhotic rats with portal hypertension. Biosci Rep. 2017;: pubmed publisher
    ..Curcumin also attenuated splanchnic hyperdynamic circulation by inducing vasoconstriction through inhibition of eNOS activation and by decreasing mesenteric angiogenesis via VEGF pathway blockade...
  31. Feigenson M, Eliseev R, Jonason J, Mills B, O Keefe R. PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism. J Cell Biochem. 2017;118:4383-4393 pubmed publisher
    ..Loss of EP1 results in inactivation of Hif1α, increased oxygen consumption rate and thus increased osteoblast differentiation. J. Cell. Biochem. 118: 4383-4393, 2017. © 2017 Wiley Periodicals, Inc. ..
  32. Sharma M, Sharma R, McCarthy E, Savin V, Srivastava T. Hyperfiltration-associated biomechanical forces in glomerular injury and response: Potential role for eicosanoids. Prostaglandins Other Lipid Mediat. 2017;132:59-68 pubmed publisher
    ..FFSS-induced COX2-PGE2-EP2 signaling provides an opportunity to identify targets and, for developing novel agents to complement currently available treatment. ..
  33. Hasan D, Hashimoto T, Kung D, MacDonald R, Winn H, Heistad D. Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results. Stroke. 2012;43:1964-7 pubmed publisher
    ..We speculate that the protective effect of aspirin against rupture of cerebral aneurysms may be mediated in part by inhibition of COX-2/mPGES-1. ..
  34. Engen S, Schreurs O, Petersen F, Blix I, Baekkevold E, Schenck K. The regulatory role of the oral commensal Streptococcus mitis on human monocytes. Scand J Immunol. 2017;: pubmed publisher
    ..This article is protected by copyright. All rights reserved...
  35. Le T, Nguyen N, Nguyen K, Doan H, Dung D, Blair D. A complete mitochondrial genome from Echinochasmus japonicus supports the elevation of Echinochasminae Odhner, 1910 to family rank (Trematoda: Platyhelminthes). Infect Genet Evol. 2016;45:369-377 pubmed publisher
    ....
  36. Zhang P, Sun C, Li H, Tang C, Kan H, Yang Z, et al. TRPV4 (Transient Receptor Potential Vanilloid 4) Mediates Endothelium-Dependent Contractions in the Aortas of Hypertensive Mice. Hypertension. 2018;71:134-142 pubmed publisher
    ..This contraction involved increased intracellular Ca2+ concentrations and cPLA2 activity. These results suggested an important role of TRPV4 in endothelium-dependent contraction in mice during hypertension. ..
  37. Leary S, Sasarman F, Nishimura T, Shoubridge E. Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1. Hum Mol Genet. 2009;18:2230-40 pubmed publisher
    ..Based on these data we present a model in which each SCO protein fulfills distinct, stage-specific functions during CO II synthesis and CuA site maturation. ..
  38. Anderson S, Bankier A, Barrell B, de Bruijn M, Coulson A, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457-65 pubmed
    ....
  39. Chowdhury R, Gales D, Valenzuela P, Miller S, Yehualaeshet T, Manne U, et al. Bromoethylindole (BEI-9) redirects NF-κB signaling induced by camptothecin and TNFα to promote cell death in colon cancer cells. Apoptosis. 2017;22:1553-1563 pubmed publisher
    ..Therefore, the combination of BEI-9 with drugs that activate NF-κB needs to be evaluated for clinical applications. ..
  40. Wolff N, Ghio A, Garrick L, Garrick M, Zhao L, Fenton R, et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J. 2014;28:2134-45 pubmed publisher
    ..We suggest that DMT1 not only exports iron from endosomes, but also serves to import the metal into the mitochondria. ..
  41. Lima J, Araújo Santos T, Lázaro Souza M, Carneiro A, Ibraim I, Jesus Santos F, et al. Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2. Sci Rep. 2017;7:14321 pubmed publisher
    ..Finally, we determined that LPG-induced PPAR-γ signaling occurred via TLR1/2. Taken together, these results reinforce the role played by L. infantum-derived LPG in the proinflammatory response seen in Leishmania infection. ..
  42. Yuan P, Zheng X, Li M, Ke Y, Fu Y, Zhang Q, et al. Two Sulfur Glycoside Compounds Isolated from Lepidium apetalum Willd Protect NRK52e Cells against Hypertonic-Induced Adhesion and Inflammation by Suppressing the MAPK Signaling Pathway and RAAS. Molecules. 2017;22: pubmed publisher
    ....
  43. Ooki A, Del Carmen Rodriguez Pena M, Marchionni L, Dinalankara W, Begum A, Hahn N, et al. YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells. Cancer Res. 2018;78:168-181 pubmed publisher
    ..i>Cancer Res; 78(1); 168-81. ©2017 AACR. ..
  44. Goodman J, Bowman E, Chanock S, Alberg A, Harris C. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis. 2004;25:2467-72 pubmed
    ..We have shown for the first time that a haplotype containing ALOX5 G-1752A and G-1699A in a negative regulatory region of the promoter may influence colon cancer risk in Caucasians. ..
  45. Bakry O, El Farargy S, El Kady N, Dawy H. Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris. J Clin Diagn Res. 2017;11:WC01-WC07 pubmed publisher
    ..It controls transcription of genes involved in lipid and fatty acid synthesis. Cyclo-oxygenase 2 (COX2) is a rate limiting enzyme in prostaglandin synthesis. It plays important role in inflammation...
  46. Sun Y, Lin H, Zhu Y, Ma C, Ye J, Luo J. Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin beta 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expression. J Cell Physiol. 2002;192:225-33 pubmed
    ..This is the first report demonstrating that the expression of mitochondria-encoded COXII is HRG-responsive. The levels of ErbB2 expression are decisive for the diverse biological activities of HRG. ..
  47. Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson I, et al. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Br J Cancer. 2008;99:2088-93 pubmed publisher
    ..In conclusion, our results provide little evidence that mitochondrial genetic background plays a role in modifying an individual's risk of developing CRC. ..
  48. Griñan Ferré C, Palomera Ávalos V, Puigoriol Illamola D, Camins A, Porquet D, Plá V, et al. Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. Exp Gerontol. 2016;80:57-69 pubmed publisher
    ..These changes are reflected in the emotional and cognitive behaviour of SAMP8 that differs from that of SAMR1 and that highlighted the importance of earlier oxidative processes in the onset of neurodegeneration...
  49. Mohammadi A, Yaghoobi M, Gholamhoseinian Najar A, Kalantari Khandani B, Sharifi H, Saravani M. HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. Inflammation. 2016;39:1116-23 pubmed publisher
    ..In conclusion, we found that inhibitory effects of 17-AAG on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 and 15-PGDH expression. ..
  50. Bohanes P, Rankin C, Blanke C, Winder T, Ulrich C, Smalley S, et al. Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation. Clin Cancer Res. 2015;21:1583-90 pubmed publisher
    ..004). rs1695 may be prognostic in patients with rectal cancer treated with adjuvant CRT. rs4073 and rs1870377 may exhibit different associations with toxicity, according to the 5-FU schedule. ..
  51. Chintha R, Kaipa P, Sekhar N, Hasan Q. Mitochondria and tumors: a new perspective. Indian J Cancer. 2013;50:206-13 pubmed publisher
    ..We hypothesize that compromised OXPHOS may be a responsive mechanism of the cell to counter cancers, rather than a mechanism of initiating tumorigenesis. ..
  52. Salem S, Aly D, Amr K, Abdel Hamid M. Study of the relation between two common cyclooxygenase 2 gene polymorphisms with risk of developing and subtypes of vitiligo in Egyptian patients. Indian J Dermatol Venereol Leprol. 2017;: pubmed publisher
    ..COX2 gene polymorphism has been previously evaluated in Chinese population. We aimed to study the relation between two common COX2 gene polymorphisms with vitiligo and its subtypes amongEgyptian patients...
  53. Oswald C, Krause Buchholz U, Rödel G. Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase. J Mol Biol. 2009;389:470-9 pubmed publisher
    ..An interdependent assembly scenario for the formation of supercomplexes that rather requires the coordinated synthesis and association of individual complexes, is proposed. ..
  54. Szczeklik W, Sanak M, Szczeklik A. Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. J Allergy Clin Immunol. 2004;114:248-53 pubmed
    ..In asthma, the COX-2 -765C homozygosity is associated with female sex. The CC homozygosity has functional effects resulting in increased capacity of monocytes to produce prostaglandins. ..
  55. Cao Q, Karthikeyan A, Dheen S, Kaur C, Ling E. Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling. PLoS ONE. 2017;12:e0186764 pubmed publisher
    ..It is concluded that the three signalling pathways are functionally interlinked in regulating microglia activation. ..
  56. Dumilag R, Gallardo W, Garcia C, You Y, Chaves A, Agahan L. Phenotypic and mtDNA variation in Philippine Kappaphycus cottonii (Gigartinales, Rhodophyta). Mitochondrial DNA A DNA Mapp Seq Anal. 2017;:1-13 pubmed publisher
    ..Assessing the breadth of the phenotypic and genetic variation in K. cottonii has implications for the conservation and management of the overall Kappaphycus genetic resources, especially in the Philippines...
  57. Jiménez Maldonado A, Ying Z, Byun H, Gomez Pinilla F. Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. Biochim Biophys Acta. 2018;1864:24-33 pubmed publisher
    ..These results advocate that a short period of fructose can influence brain plasticity without a major peripheral metabolic dysfunction. ..
  58. Liu S, Pan G, Liu G, Neves J, Song S, Chen S, et al. Electrospun fibrous membranes featuring sustained release of ibuprofen reduce adhesion and improve neurological function following lumbar laminectomy. J Control Release. 2017;264:1-13 pubmed publisher
    ..Overall, this study provided evidence that precisely engineered IBU-loaded electrospun fibrous membranes may be useful in preventing FBSS and able to potentially impact the outcome of patients undergoing spine surgery. ..
  59. El Badawi Z, Muhammad E, Noaman H. Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. Malays J Pathol. 2012;34:15-23 pubmed
    ..Immunostaining of COX 2 and osteocalcin were studied in 9 osteoblastomas and 30 osteosarcomas...
  60. Salker M, Singh Y, Durairaj R, Yan J, Alauddin M, Zeng N, et al. LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry. J Mol Med (Berl). 2017;: pubmed publisher
    ..These findings suggest that LEFTY2 closes the implantation window, at least in part, by downregulating Orai1, which in turn limits SOCE and antagonizes expression of Ca2+-sensitive receptivity genes...
  61. Corona G, Deiana M, Incani A, Vauzour D, Dessi M, Spencer J. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007;362:606-11 pubmed
    ..9+/-9.3%). Our data suggest that olive oil polyphenols may exert chemopreventative effects in the large intestine by interacting with signalling pathways responsible for colorectal cancer development. ..
  62. Fujii J, Niida S, Yasunaga Y, Yamasaki A, Ochi M. Wear debris stimulates bone-resorbing factor expression in the fibroblasts and osteoblasts. Hip Int. 2011;21:231-7 pubmed
    ....