corticosteroid binding globulin

Summary

Gene Symbol: corticosteroid binding globulin
Description: serpin family A member 6
Alias: CBG, corticosteroid-binding globulin, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, serpin A6, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, transcortin
Species: human

Top Publications

  1. Hammond G, Smith C, Goping I, Underhill D, Harley M, Reventos J, et al. Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. Proc Natl Acad Sci U S A. 1987;84:5153-7 pubmed
    We have isolated and sequenced cDNAs for corticosteroid binding globulin (CBG) prepared from human liver and lung mRNAs...
  2. Fernandez Real J, Pugeat M, Grasa M, Broch M, Vendrell J, Brun J, et al. Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study. J Clin Endocrinol Metab. 2002;87:4686-90 pubmed
    ..Corticosteroid-binding globulin (CBG), the main plasma protein transport for cortisol, has been shown to be negatively regulated by insulin and IL-6, at ..
  3. Zhou A, Wei Z, Stanley P, Read R, Stein P, Carrell R. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008;380:244-51 pubmed publisher
    Corticosteroids are transported in the blood by a serpin, corticosteroid-binding globulin (CBG), and their normally equilibrated release can be further triggered by the cleavage of the reactive loop of CBG...
  4. Lin H, Underhill C, Gardill B, Muller Y, Hammond G. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem. 2009;284:884-96 pubmed publisher
    Corticosteroid-binding globulin (CBG) is a non-inhibitory serine proteinase inhibitor (serpin) that transports cortisol and progesterone in blood...
  5. Torpy D, Bachmann A, Grice J, Fitzgerald S, Phillips P, Whitworth J, et al. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J Clin Endocrinol Metab. 2001;86:3692-700 pubmed
    ..As idiopathic fatigue disorders are associated with relatively low plasma cortisol, abnormalities of corticosteroid-binding globulin may be pathogenic. ..
  6. Lewis J, Borowski K, Shand B, George P, Scott R. Plasma sex hormone-binding globulin, corticosteroid-binding globulin, cortisol, and free cortisol levels in outpatients attending a lipid disorders clinic: a cross-sectional study of 1137 subjects. Horm Metab Res. 2010;42:274-9 pubmed publisher
    We measured plasma sex hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), and total cortisol, and calculated free plasma cortisol in 1 137 subjects attending a hospital outpatient lipid disorders clinic to ..
  7. Li Y, Wu L, Lei J, Zhu C, Wang H, Yu X, et al. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci. 2012;55:699-708 pubmed publisher
    Corticosteroid-binding globulin (CBG) is a high-affinity plasma protein that transports glucocorticoids and progesterone...
  8. Underhill D, Hammond G. Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region. Mol Endocrinol. 1989;3:1448-54 pubmed
    The structure of the human corticosteroid binding globulin (CBG) gene has been determined, and restriction endonuclease maps of human placental DNA and cloned genomic DNA indicate that CBG is encoded by a single gene...
  9. Emptoz Bonneton A, Cousin P, Seguchi K, Avvakumov G, Bully C, Hammond G, et al. Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000;85:361-7 pubmed
    Corticosteroid-binding globulin (CBG) is the plasma transport protein that regulates the access of glucocorticoid hormones to target cells...

More Information

Publications103 found, 100 shown here

  1. Fernandez Real J, Pugeat M, Lopez Bermejo A, Bornet H, Ricart W. Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women. Metabolism. 2005;54:584-9 pubmed
    ..As previous studies have demonstrated an inverse relationship between corticosteroid-binding globulin (CBG), body mass index, and insulin resistance, we studied whether CBG could explain cortisol-to-adiponectin ..
  2. Barat P, Duclos M, Gatta B, Roger P, Mormede P, Moisan M. Corticosteroid binding globulin gene polymorphism influences cortisol driven fat distribution in obese women. Obes Res. 2005;13:1485-90 pubmed
    ..We investigated the hypothesis that corticosteroid-binding globulin (CBG) polymorphism could influence obesity, metabolic, or hypothalamo-pituitary adrenal (HPA) axis activity parameters...
  3. Holliday K, Macfarlane G, Nicholl B, Creed F, Thomson W, McBeth J. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. J Psychosom Res. 2010;68:469-74 pubmed publisher
    ..This study finds association of SNPs in HTR2A, SERPINA6, and TPH2 with somatic symptoms implicating them as potentially important in the shared genetic component to functional somatic syndromes, although replication is required. ..
  4. Qi X, Loiseau F, Chan W, Yan Y, Wei Z, Milroy L, et al. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. J Biol Chem. 2011;286:16163-73 pubmed publisher
    The release of hormones from thyroxine-binding globulin (TBG) and corticosteroid-binding globulin (CBG) is regulated by movement of the reactive center loop in and out of the β-sheet A of the molecule...
  5. Lin H, Underhill C, Lei J, Helander Claesson A, Lee H, Gardill B, et al. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab. 2012;97:E678-86 pubmed publisher
    Cortisol is transported by corticosteroid-binding globulin (CBG) in blood. Single nucleotide polymorphisms (SNP) in the human CBG (SERPINA6) gene that disrupt CBG production or steroid binding are considered rare...
  6. Sumer Bayraktar Z, Kolarich D, Campbell M, Ali S, Packer N, Thaysen Andersen M. N-glycans modulate the function of human corticosteroid-binding globulin. Mol Cell Proteomics. 2011;10:M111.009100 pubmed publisher
    Human corticosteroid-binding globulin (CBG), a heavily glycosylated protein containing six N-linked glycosylation sites, transports cortisol and other corticosteroids in blood circulation...
  7. Szkodziak P, Czuczwar P, Woźniak S, Szkodziak F, Paszkowski T. Use of a levonorgestrel-releasing intrauterine device for menorrhagia treatment during adjuvant therapy of adrenocortical carcinoma with mitotane. Ginekol Pol. 2017;88:576-577 pubmed publisher
    ..It has been suggested, that mitotane also affects the peripheral metabolism of steroids, especially of transcortin (CBG). This results in an increase of CBG blood concentration and a reduction of the amount of free hormones.
  8. Gemmel M, Hazlett M, Bögi E, De Lacalle S, Hill L, Kokras N, et al. Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. 2017;84:159-171 pubmed publisher
    ..Perinatal fluoxetine also increased serum corticosteroid binding globulin levels, 5-HT levels in the hippocampus, and pre-synaptic density assessed via synaptophysin in the ..
  9. Bae Y, Reinelt J, Netto J, Uhlig M, Willenberg A, Ceglarek U, et al. Salivary cortisone, as a biomarker for psychosocial stress, is associated with state anxiety and heart rate. Psychoneuroendocrinology. 2019;101:35-41 pubmed publisher
    ..Our results can inform future stress studies of sampling time for different laboratory parameters. ..
  10. Dietrich M, Hliwa P, Adamek M, Steinhagen D, Karol H, Ciereszko A. Acclimation to cold and warm temperatures is associated with differential expression of male carp blood proteins involved in acute phase and stress responses, and lipid metabolism. Fish Shellfish Immunol. 2018;76:305-315 pubmed publisher
    ..to the proteins involved in lipid metabolism (apolipoproteins A and 14?kDa) and stress response (corticosteroid binding globulin)...
  11. Gemmel M, Harmeyer D, Bögi E, Fillet M, Hill L, Hammond G, et al. Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam. Behav Brain Res. 2018;339:222-231 pubmed publisher
    ..Measures of serum corticosterone and corticosteroid-binging globulin (CBG) and the number of immature neurons in the dorsal hippocampus were also assessed in the late postpartum...
  12. Yilmaz Z, Eralp Inan O, Kocaturk M, Baykal A, Hacariz O, Hatipoglu I, et al. Changes in serum proteins after endotoxin administration in healthy and choline-treated calves. BMC Vet Res. 2016;12:210 pubmed publisher
    ..protein (189-fold) and galectin-3-binding protein (10-fold), but transcription factor MafF and corticosteroid binding globulin were down regulated (??5 fold)...
  13. Patel B, Wene D, Fan Z. Qualitative and quantitative measurement of cannabinoids in cannabis using modified HPLC/DAD method. J Pharm Biomed Anal. 2017;146:15-23 pubmed publisher
    ..The change in the mobile phase and the new column ensured a separation between cannabidiol (CBD and cannabigerol (CBG) along with cannabigerol and tetrahydrocannabinolic acid (THCA), which were not well separated by previous ..
  14. Tsonkova V, Sand F, Wolf X, Grunnet L, Kirstine Ringgaard A, Ingvorsen C, et al. The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. Mol Metab. 2018;8:144-157 pubmed publisher
    ..Based on its robust performance during the functionality assessment assays, the EndoC-βH1 cell line was successfully used as a screening platform for identification of novel anti-diabetic drug candidates. ..
  15. Petrosino S, Verde R, Vaia M, Allarà M, Iuvone T, Di Marzo V. Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis. J Pharmacol Exp Ther. 2018;365:652-663 pubmed publisher
    ..This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of ACD. ..
  16. Sivukhina E, Jirikowski G. Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis. Steroids. 2016;111:21-28 pubmed publisher
    ..The role of both systems in the pathogenesis of various chronic ailments in humans has extensively been studied. Their disturbed functioning seems to be linked to various psychiatric, autoimmune and cardiovascular pathologies. ..
  17. Qin Y, Zhong Y, Yang G, Ma T, Jia L, Huang C, et al. Profiling of concanavalin A-binding glycoproteins in human hepatic stellate cells activated with transforming growth factor-β1. Molecules. 2014;19:19845-67 pubmed publisher
    ..approach using lectin-magnetic particle conjugate-based liquid chromatography-tandem mass spectrometry to compare CBG profiles between LX-2 HSCs with and without activation by TGF-β1, with the aim of discovering novel CBGs and ..
  18. Boero G, Pisu M, Biggio F, Muredda L, Carta G, Banni S, et al. Impaired glucocorticoid-mediated HPA axis negative feedback induced by juvenile social isolation in male rats. Neuropharmacology. 2018;133:242-253 pubmed publisher
  19. Boonstra R, Dusek A, Lane J, Boutin S. When the ball is in the female's court: How the scramble-competition mating system of the North American red squirrel has shaped male physiology and testosterone dynamics. Gen Comp Endocrinol. 2017;252:162-172 pubmed publisher
    ..cortisol was higher in non-breeding males, free cortisol was twice as high in breeding males as their corticosteroid binding globulin levels were half as high...
  20. Rahdar H, Golmohammadi R, Mirnejad R, Ataee R, Alishiri G, Kazemian H. Diversity of virulence genes in Brucella melitensis and Brucella abortus detected from patients with rheumatoid arthritis. Microb Pathog. 2018;118:247-250 pubmed publisher
    ..After gel electrophoresis, the PCR products were confirmed by DNA sequencing. The cbg, omp31, manA, virB, and znuA virulence genes typing were performed by multiplex-PCR...
  21. Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, et al. Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study. PLoS ONE. 2012;7:e39603 pubmed publisher
    ..This study identifies 20 novel fibrosis biomarker candidates. The proteins identified may help to assess hepatic fibrosis and eliminate the need for invasive liver biopsies. ..
  22. Citti C, Pacchetti B, Vandelli M, Forni F, Cannazza G. Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA). J Pharm Biomed Anal. 2018;149:532-540 pubmed publisher
    ..tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidivarin (CBDV), present in 13 commercial hemp seed oils...
  23. Kanitz E, Otten W, Tuchscherer M, Gräbner M, Brüssow K, Rehfeldt C, et al. High and low protein∶ carbohydrate dietary ratios during gestation alter maternal-fetal cortisol regulation in pigs. PLoS ONE. 2012;7:e52748 pubmed publisher
  24. Murani E, Ponsuksili S, Jaeger A, Görres A, Tuchscherer A, Wimmers K. A naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus-pituitary-adrenal axis activity early in ontogeny. Open Biol. 2016;6: pubmed publisher
    ..Therefore, GRAla610Val pigs represent a valuable animal model to explore GR-mediated mechanisms of HPA axis regulation and responses to glucocorticoid-based drugs. ..
  25. Magnet F, Windisch W, Storre J. [Monitoring of pCO2 during ventilation]. Med Klin Intensivmed Notfmed. 2016;111:202-7 pubmed publisher
    ..Another method to evaluate pCO2 is capillary blood gas analysis (CBG)...
  26. Edwards P, Palme R, Boonstra R. Seasonal programming, not competition or testosterone, drives stress-axis changes in a partially-semelparous mammal. Horm Behav. 2016;85:96-101 pubmed publisher
    ..We found no evidence that testosterone plays a role in maintaining elevated free cortisol in arctic ground squirrel males. ..
  27. Reimondo G, Puglisi S, Zaggia B, Basile V, Saba L, Perotti P, et al. Effects of mitotane on the hypothalamic-pituitary-adrenal axis in patients with adrenocortical carcinoma. Eur J Endocrinol. 2017;177:361-367 pubmed publisher
    ..We demonstrated a close correlation between cortisol-binding globulin (CBG) and plasma mitotane levels, and a non-significant trend between mitotane dose and either serum or salivary ..
  28. Rosner W, Beers P, Awan T, Khan M. Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay. J Clin Endocrinol Metab. 1976;42:1064-73 pubmed
    ..A filter disk assay was developed both for the measurement of plasma corticosteroid-binding globulin (CBG) and for the cortisol-binding protein in milk...
  29. Mostowska A, Hozyasz K, Wojcicka K, Lianeri M, Jagodzinski P. Polymorphisms of stress-related genes and the risk of nonsyndromic cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol. 2011;91:948-55 pubmed publisher
    ..SLC6A4, TPH2, and SERPINA6 might be novel candidate genes for this common congenital anomaly. ..
  30. Henley D, Brown S, Pennell C, Lye S, Torpy D. Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia. Clin Endocrinol (Oxf). 2016;85:583-9 pubmed publisher
    ..Plasma ACTH, total cortisol, corticosteroid-binding globulin (CBG) and free cortisol calculated by Coolens' equation were measured from the blood samples collected at home before 10:..
  31. Sanz Martin I, Ferrantino L, Vignoletti F, Nunez J, Baldini N, Duvina M, et al. Contour changes after guided bone regeneration of large non-contained mandibular buccal bone defects using deproteinized bovine bone mineral and a porcine-derived collagen membrane: an experimental in vivo investigation. Clin Oral Investig. 2018;22:1273-1283 pubmed publisher
    ..using a bone replacement graft (BRG), resorbable collagen membrane (MBG), or a combination of both procedures (CBG)...
  32. England J, Drouin S, Beaulieu P, St Onge P, Krajinovic M, Laverdiere C, et al. Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors. BMC Cancer. 2017;17:751 pubmed publisher
    ..These biomarkers could be used as early detection strategies to identify susceptible individuals and implement appropriate measures and follow-up to prevent the development of risk factors in this high-risk population. ..
  33. Hammond G. Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action. J Endocrinol. 2016;230:R13-25 pubmed publisher
    ..are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG)...
  34. Scheidweiler K, Newmeyer M, Barnes A, Huestis M. Quantification of cannabinoids and their free and glucuronide metabolites in whole blood by disposable pipette extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2016;1453:34-42 pubmed publisher
    ..Other minor cannabinoids cannabigerol (CBG), Δ9-tetrahydrocannabivarin (THCV), and its metabolite 11-nor-9-carboxy-THCV (THCVCOOH) might also be useful...
  35. Nenke M, Lewis J, Rankin W, Torpy D. Evidence of Reduced CBG Cleavage in Abdominal Obesity: A Potential Factor in Development of the Metabolic Syndrome. Horm Metab Res. 2016;48:523-8 pubmed publisher
    Corticosteroid-binding globulin (CBG) is involved in the regulation of cortisol delivery. Neutrophil elastase-mediated cleavage of high to low affinity CBG (haCBG to laCBG) induces cortisol release at inflammatory sites...
  36. Lu X, Qiao Y, Li Y, Yang B, Chen M, Xing C. Preclinical study of cinobufagin as a promising anti-colorectal cancer agent. Oncotarget. 2017;8:988-998 pubmed publisher
    Here, we assessed the anti-colorectal cancer (CRC) cell activity of cinobufagin (CBG). We found that CBG exerted potent cytotoxic and anti-proliferative activity against CRC lines (HCT-116 and HT-29) and primary human CRC cells...
  37. Brandl H, Moon H, Vila Farré M, Liu S, Henry I, Rink J. PlanMine--a mineable resource of planarian biology and biodiversity. Nucleic Acids Res. 2016;44:D764-73 pubmed publisher
    ..PlanMine (http://planmine.mpi-cbg.de/) aims to accomplish two primary missions: First, to provide an easily accessible platform for sharing, ..
  38. Bodor E, Wu W, Chandran V, Bodor N. Enhanced Activity of Topical Hydrocortisone by Competitive Binding of Corticosteroid-Binding Globulin. J Pharm Sci. 2016;105:2873-2878 pubmed publisher
    ..of prednisolone, Δ(1)-cortienic acid (Δ(1)-CA), is added to HC, as Δ(1)-CA preferentially binds transcortin, liberating more HC to elicit its therapeutic effect...
  39. Wu S, Yi P, Guo X, Zhang L, Xu D, Fu Y, et al. Cinobufagin enhances the protective efficacy of formalin-inactivated Salmonella typhimurium vaccine through Th1 immune response. Microb Pathog. 2016;99:264-270 pubmed publisher
    Cinobufagin (CBG), one active ingredient isolated from Venenum Bufonis, has been demonstrated to have immunoregulatory effect...
  40. Wojcik E, Smalec E. Constitutive heterochromatin in chromosomes of duck hybrids and goose hybrids. Poult Sci. 2017;96:18-26 pubmed
    ..Heterochromatin is located in the centromeric, telomeric, and interstitial parts of chromosomes. We used the CBG ( C: banding using B: arium hydroxide by G: iemsa) staining technique to identify heterochromatin in chromosomes...
  41. Simard M, Underhill C, Hammond G. Functional implications of corticosteroid-binding globulin N-glycosylation. J Mol Endocrinol. 2018;60:71-84 pubmed publisher
    Corticosteroid-binding globulin (CBG) is a plasma carrier of glucocorticoids. Human and rat CBGs have six N-glycosylation sites...
  42. Smeriglio A, Giofrè S, Galati E, Monforte M, Cicero N, D Angelo V, et al. Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. Fitoterapia. 2018;127:101-108 pubmed publisher
    ..chemotypes with high content of cannabidiol (CBD)/cannabidiolic acid (CBDA) and cannabigerol (CBG)/cannabigerolic acid (CBGA), respectively, on human recombinant and pig kidney aldose reductase activity in vitro...
  43. Powell F, Harper S, Callaghan C, Shaw A, Godfrey E, Bradley J, et al. Postoperative CT in pancreas transplantation. Clin Radiol. 2015;70:1220-8 pubmed publisher
    ..6%), a normal scan (17.1%) and fluid collections (16.3%). High capillary blood glucose (CBG) was associated with resultant CT demonstration of graft vascular abnormalities, but otherwise, particular clinical ..
  44. Del Corral P, Schurman R, Kinza S, FitzGerald M, Kordick C, Rusch J, et al. Salivary but not plasma cortisone tracks the plasma cortisol response to exercise: effect of time of day. J Endocrinol Invest. 2016;39:315-22 pubmed publisher
    The cortisol, cortisone, corticosterone, and CBG responses to exercise in the AM and PM have not been described...
  45. Nenke M, Holmes M, Rankin W, Lewis J, Torpy D. Corticosteroid-binding globulin cleavage is paradoxically reduced in alpha-1 antitrypsin deficiency: Implications for cortisol homeostasis. Clin Chim Acta. 2016;452:27-31 pubmed publisher
    ..We hypothesized that AATD may result in increased CBG cleavage in vivo...
  46. Jones G, Khan J, Sainsbury C. Is all hypoglycaemia treated as equal? An observational study of how the type of diabetes and treatment prescribed prior to admission influences quality of treatment of inpatient hypoglycaemia. Acta Diabetol. 2017;54:247-250 pubmed publisher
    ..We aimed to investigate this apparent discrepancy, utilising the time to repeat (TTR) capillary blood glucose (CBG) measurement as a surrogate for engagement with guidelines stating that CBG should be rechecked following ..
  47. DeGuzman P, Cohn W, Camacho F, Edwards B, Sturz V, Schroen A. Impact of Urban Neighborhood Disadvantage on Late Stage Breast Cancer Diagnosis in Virginia. J Urban Health. 2017;94:199-210 pubmed publisher
    ..We used census block group- (CBG) level poverty indicators from five Virginia cities to develop the index...
  48. Alwan D, Chipps E, Yen P, Dungan K. Evaluation of the timing and coordination of prandial insulin administration in the hospital. Diabetes Res Clin Pract. 2017;131:18-32 pubmed publisher
    ..study was to examine the relationship between measures of coordinated insulin delivery and capillary blood glucose (CBG) levels among hospitalized patients and to assess nurse perceptions of insulin administration...
  49. Lewis J, Jones L, Legge M, Elder P. Corticosteroid-binding globulin, cortisol, free cortisol, and sex hormone-binding globulin responses following oral glucose challenge in spinal cord-injured and able-bodied men. Horm Metab Res. 2010;42:882-6 pubmed publisher
    ..There were no significant changes in plasma sex hormone-binding globulin in either group. ..
  50. Nandha Premnath P, Craig S, McInnes C. Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors. J Vis Exp. 2015;:e52441 pubmed publisher
    ..Targeting the protein-protein interaction at the cyclin binding groove (CBG) is an approach which will allow the specific inhibition of cell cycle over transcriptional CDKs...
  51. Hawley J, Owen L, Lockhart S, Monaghan P, Armston A, Chadwick C, et al. Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance. Clin Chem. 2016;62:1220-9 pubmed publisher
    ..in all samples using an LC-MS/MS candidate reference measurement procedure (cRMP); cortisol-binding globulin (CBG) was measured in the nonpregnant and pregnant female cohorts...
  52. Lewis J, Saunders K, Dyer A, Elder P. The half-lives of intact and elastase cleaved human corticosteroid-binding globulin (CBG) are identical in the rabbit. J Steroid Biochem Mol Biol. 2015;149:53-7 pubmed publisher
    Corticosteroid-binding globulin (CBG) is a non-inhibitory member of the serpin superfamily of serine protease inhibitors and carries the majority of cortisol in circulation...
  53. Brierley D, Samuels J, Duncan M, Whalley B, Williams C. Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology (Berl). 2016;233:3603-13 pubmed publisher
    ..One possible candidate is the non-psychoactive phytocannabinoid cannabigerol (CBG), which has affinity for several molecular targets with known involvement in the regulation of feeding behaviour...
  54. Duan R, Zhang J, Liu L, Cui W, Regenstein J. The functional properties and application of gelatin derived from the skin of channel catfish (Ictalurus punctatus). Food Chem. 2018;239:464-469 pubmed publisher
    ..catfish gelatin (CCG) had more high molecular weight components (? and ? chains) than had calf bone gelatin (CBG). The viscosity of CCG was 42mPa.s at 10°C, which was three times more than that of CBG...
  55. Hu C, Lau A, Wang R, Chang T. Comparative analysis of ginsenosides in human glucocorticoid receptor binding, transactivation, and transrepression. Eur J Pharmacol. 2017;815:501-511 pubmed publisher
    ..The number of glycosylated groups was associated with a decrease in receptor binding potency. PPD-type and PPT-type ginsenosides are not modulators of glucocorticoid receptor transactivation or transrepression in LS180 and HepG2 cells. ..
  56. Brotherton J. Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays. Andrologia. 1990;22:197-204 pubmed
    ..Transcortin (corticosteroid binding globulin, CBG), has been found in human seminal plasma and amniotic fluid for the first time...
  57. Kato E, Hsu B, Kuhn R. Comparative structural analyses of corticosteroid binding globulin. J Steroid Biochem. 1988;29:213-20 pubmed
    Some physicochemical characteristics of corticosteroid binding globulin (CBG) in several species have been determined...
  58. Misao R, Hori M, Ichigo S, Fujimoto J, Tamaya T. Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis. Reprod Nutr Dev. 1995;35:155-65 pubmed
    Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells...
  59. Brunner E, Baima J, Vieira T, Vieira J, Abucham J. Hereditary corticosteroid-binding globulin deficiency due to a missense mutation (Asp367Asn, CBG Lyon) in a Brazilian kindred. Clin Endocrinol (Oxf). 2003;58:756-62 pubmed
    Abnormal corticosteroid-binding globulin (CBG) is an extremely rare condition and only three mutations have been described in four families...
  60. Namciu S, Friedman R, Marsden M, Sarausad L, Jasoni C, Fournier R. Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1. Mamm Genome. 2004;15:162-78 pubmed
    ..Several differences between the MAR-Wiz predictions and the results of biochemical tests were observed. The genomic organization of the serpin gene cluster is discussed. ..
  61. Holliday K, Nicholl B, Macfarlane G, Thomson W, Davies K, McBeth J. Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study. Ann Rheum Dis. 2010;69:556-60 pubmed publisher
    ..Genetic variation in HPA axis genes was associated with musculoskeletal pain; however, some of the associations were explained by comorbidities. Replication of these findings is required in independent cohorts. ..
  62. Braun B, Meyer H, Reetz A, Fuhrmann U, Köhrle J. Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity. J Steroid Biochem Mol Biol. 2010;120:30-7 pubmed publisher
    Corticosteroid-binding globulin (CBG, transcortin) belongs to the serpin family of serine protease inhibitors (SERPINA6) and is mainly secreted by the liver...
  63. Verhoog N, Allie Reid F, Vanden Berghe W, Smith C, Haegeman G, Hapgood J, et al. Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ. PLoS ONE. 2014;9:e110702 pubmed publisher
    Corticosteroid-binding globulin (CBG), a negative acute phase protein produced primarily in the liver, is responsible for the transport of glucocorticoids (GCs)...
  64. Swortwood M, Newmeyer M, Andersson M, Abulseoud O, Scheidweiler K, Huestis M. Cannabinoid disposition in oral fluid after controlled smoked, vaporized, and oral cannabis administration. Drug Test Anal. 2017;9:905-915 pubmed publisher
    ..11-OH-THC), 11-nor-9-carboxy-THC (THCCOOH), tetrahydrocannabivarin (THCV), cannabidiol (CBD), and cannabigerol (CBG) were quantified by liquid chromatography-tandem mass spectrometry...
  65. Fratto M, Hart K, Norton N, Barton M, Giguere S, Hurley D. The effect of free and carrier-bound cortisol on equine neutrophil function. Vet Immunol Immunopathol. 2017;183:16-21 pubmed publisher
    ..hormone that increases in bacterial sepsis and circulates predominantly bound to cortisol binding globulin (CBG)...
  66. Vidler J, Rogers C, Yallop D, Devereux S, Wellving E, Stewart O, et al. Outpatient management of steroid-induced hyperglycaemia and steroid-induced diabetes in people with lymphoproliferative disorders treated with intermittent high dose steroids. J Clin Transl Endocrinol. 2017;9:18-20 pubmed publisher
    ..All patients (n = 34) subsequently prescribed HDS checked capillary blood glucose (CBG) pre-breakfast and pre-evening meal...
  67. Loric S, Egloff M, Domingo M, Lacronique J, Degrelle H. Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid. Clin Chim Acta. 1989;186:19-23 pubmed
    The corticosteroid-binding globulin (CBG) is a plasma protein which is present both in liver, where it is mainly synthesized, and in cells of different target tissues for glucocorticoids...
  68. Bardin C, Gunsalus G, Musto N, Cheng C, Reventos J, Smith C, et al. Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors. J Steroid Biochem. 1988;30:131-9 pubmed
    The cDNA nucleotide sequences and the deduced amino acid sequences of human corticosteroid binding globulin (hCBG), human testosterone-estradiol binding globulin (hTeBG), and rat androgen binding protein (rABP) were determined...
  69. Misao R, Nakanishi Y, Fujimoto J, Ichigo S, Hori M, Tamaya T. Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers. Steroids. 1995;60:720-4 pubmed
    Since it has been demonstrated that corticosteroid-binding globulin (CBG) plays a role in intracellar steroidal actions in target cells, the expression of CBG mRNA as the measure of CBG expression was investigated in human endometrial ..
  70. Rollini P, Fournier R. Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1. Mamm Genome. 1997;8:913-6 pubmed
    The genes encoding alpha 1-antitrypsin (alpha 1AT; gene symbol PI) and corticosteroid-binding globulin (CBG) are part of a cluster of structurally related serine protease inhibitor (serpin) genes on human Chromosome (Chr) 14q32.1...
  71. Torpy D, Bachmann A, Gartside M, Grice J, Harris J, Clifton P, et al. Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism. Endocr Res. 2004;30:417-29 pubmed
    ..Recently, severe corticosteroid-binding globulin (CBG) gene mutations have been associated with CFS in isolated kindreds...
  72. Cyr D, Lucas J, Thompson J, Patel K, Clark P, Thompson A, et al. Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. PLoS ONE. 2011;6:e21854 pubmed publisher
    ..treatment response genotype (rs12979860_CC) was significantly associated with lower serum levels of corticosteroid binding globulin (CBG; p?=?9.2×10(-6)), a major transport protein for glucocorticoids and progestins...
  73. Barat P, Corcuff J, Tauber M, Moisan M. Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children. J Physiol Biochem. 2012;68:645-50 pubmed publisher
    ..Overall, this study provides new data showing the influence of glucocorticoid receptor and corticosteroid-binding globulin genes in obesity and/or cortisol action in prepubertal obese children. ..
  74. Shen N, Gong J, Wang Y, Tian J, Qian J, Zou L, et al. Integrative genomic analysis identifies that SERPINA6-rs1998056 regulated by FOXA/ERα is associated with female hepatocellular carcinoma. PLoS ONE. 2014;9:e107246 pubmed publisher
    ..032; Group test: P = 0.060). In summary, our study suggested that SERPINA6-rs1998056 regulated by FOXA/ERα might be associated with female HCC risk. ..
  75. LeWinter M, Taatjes D, Ashikaga T, PALMER B, Bishop N, VanBuren P, et al. Abundance, localization, and functional correlates of the advanced glycation end-product carboxymethyl lysine in human myocardium. Physiol Rep. 2017;5: pubmed publisher
    ..carboxymethyl lysine (CML) in left ventricular (LV) myocardium from patients undergoing coronary bypass grafting (CBG)...
  76. Verbeeten K, Ahmet A. The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency. J Pediatr Endocrinol Metab. 2017;: pubmed publisher
    Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation...
  77. Hammond G, Langley M. Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva. Acta Endocrinol (Copenh). 1986;112:603-8 pubmed
    Sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) were detected by specific immunoassays in mixed-saliva taken from normal men and women...
  78. Avvakumov G, Hammond G. Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites. Biochemistry. 1994;33:5759-65 pubmed
    Human corticosteroid-binding globulin (CBG) comprises 383 amino acids and six consensus sites for attachment of N-acetyllactosamine-type oligosaccharides...
  79. Baltes P, Sanchez R, Pena P, Villegas J, Turley H, Miska W. Evidence for the synthesis and secretion of a CBG-like serpin by human cumulus oophorus and fallopian tubes. Andrologia. 1998;30:249-53 pubmed
    ..of cumulus cells, the results obtained here demonstrate the secretion of a corticosteroid-binding globulin (CBG)-like protein. An AR-inducing effect was shown with the culture medium of human cumulus oophorus...
  80. Miska W, Pena P, Villegas J, Sanchez R. Detection of a CBG-like protein in human Fallopian tube tissue. Andrologia. 2004;36:41-6 pubmed
    ..of human follicular fluid, has been found to be immunologically identical with corticosteroid-binding globulin (CBG), which is well characterized and serves as a transport protein for progesterone and cortisol in the plasma...
  81. Torpy D, Ho J. Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 2007;67:161-7 pubmed
    Corticosteroid-binding globulin (CBG) binds cortisol with high affinity, facilitating transport of cortisol in blood, although tissue-specific CBG-cortisol interactions have long been postulated...
  82. Hanna C, Bretherick K, Liu C, Stephenson M, Robinson W. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. Hum Reprod. 2010;25:2664-71 pubmed publisher
  83. Cizza G, Bernardi L, Smirne N, Maletta R, Tomaino C, Costanzo A, et al. Clinical manifestations of highly prevalent corticosteroid-binding globulin mutations in a village in southern Italy. J Clin Endocrinol Metab. 2011;96:E1684-93 pubmed publisher
    Corticosteroid-binding globulin (CBG) is the binding protein for cortisol...
  84. Gardill B, Vogl M, Lin H, Hammond G, Muller Y. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS ONE. 2012;7:e52759 pubmed publisher
    Corticosteroid-binding globulin (CBG) transports glucocorticoids and progesterone in the blood and thereby modulates the tissue availability of these hormones...
  85. Chung T, Gunganah K, Monson J, Drake W. Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin concentrations. Clin Endocrinol (Oxf). 2016;84:496-500 pubmed publisher
    ..One potential determinant of the bioavailability of replaced HC is a variation in serum cortisol-binding globulin (CBG) concentration, which may, in turn, affect interpretation of cortisol profiles and individual dose selection for ..
  86. Lewis J, Elder P. Monoclonal antibodies to the reactive centre loop (RCL) of human corticosteroid-binding globulin (CBG) can protect against proteolytic cleavage. J Steroid Biochem Mol Biol. 2017;171:247-253 pubmed publisher
    Corticosteroid-binding globulin (CBG) binds most of the cortisol in circulation and is a non-functional member of the family of serine protease inhibitors (serpins) with an exposed elastase sensitive reactive centre loop (RCL)...
  87. Caldwell J, Londe K, Ochs S, Hajdu Z, Rodewald A, Gebhart V, et al. Three steroid-binding globulins, their localization in the brain and nose, and what they might be doing there. Steroids. 2019;142:48-54 pubmed publisher
    Steroid-binding globulins (SBGs) such as sex hormone binding globulin, corticosteroid binding globulin, and vitamin-D binding protein are receiving increasing notice as being actively involved in steroid actions...
  88. Byth B, Billingsley G, Cox D. Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency. Am J Hum Genet. 1994;55:126-33 pubmed
    ..that includes the alpha 1-antichymotrypsin (AACT), protein C inhibitor (PCI), and corticosteroid-binding globulin (CBG) genes and the alpha 1-antitrypsin-like pseudogene (PIL)...
  89. Van Baelen H, Power S, Hammond G. Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93. Steroids. 1993;58:275-7 pubmed
    Genomic DNA was isolated from two related individuals who are homozygous for transcortin Leuven, a corticosteroid-binding globulin variant with decreased cortisol-binding affinity...
  90. Misao R, Nakanishi Y, Fujimoto J, Ichigo S, Tamaya T. Expression of sex hormone-binding globulin and corticosteroid-binding globulin mRNAs in corpus luteum of human subjects. Horm Res. 1997;48:191-5 pubmed
    ..luteum, the expression of intracellular sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) mRNAs as a manifestation of intracellular SHBG and CBG expression was determined...
  91. Garrido N, Krüssel J, Remohi J, Simon C, Pellicer A. Expression and function of 3beta hydroxisteroid dehydrogenase (3beta HSD) type II and corticosteroid binding globulin (CBG) in granulosa cells from ovaries of women with and without endometriosis. J Assist Reprod Genet. 2002;19:24-30 pubmed
    To investigate the secretion of progesterone (P4) and corticosteroid binding globulin (CBG) by granulosa luteal cells (GC) as well as the mRNA levels of CBG and 3beta hydroxisteroid dehydrogenase (3beta HSD), in women with and without ..
  92. Pusch L, Wegmann S, Caldwell J, Jirikowski G. Expression of corticosteroid-binding globulin in human astrocytoma cell line. Cell Mol Neurobiol. 2009;29:583-8 pubmed publisher
    ..Here we studied the expression of corticosteroid-binding globulin (CBG) in the low-grade malignant human astrocytoma cell line 1321N1...