cortactin

Summary

Gene Symbol: cortactin
Description: cortactin
Alias: EMS1, src substrate cortactin, 1110020L01Rik, amplaxin, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate), oncogene EMS1
Species: human
Products:     cortactin

Top Publications

  1. Cantarelli V, Kodama T, Nijstad N, Abolghait S, Iida T, Honda T. Cortactin is essential for F-actin assembly in enteropathogenic Escherichia coli (EPEC)- and enterohaemorrhagic E. coli (EHEC)-induced pedestals and the alpha-helical region is involved in the localization of cortactin to bacterial attachment sites. Cell Microbiol. 2006;8:769-80 pubmed
    ..Using siRNA, we show here that EPEC- and EHEC-induced pedestals are dependent on cortactin, an F-actin-binding protein found in the mammalian cell cortex...
  2. Cantarelli V, Kodama T, Nijstad N, Abolghait S, Nada S, Okada M, et al. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. Cell Microbiol. 2007;9:1782-95 pubmed
    ..effectors into the host cells is required to trigger the recruitment and activation of proteins, such as cortactin, neural Wiskott-Aldrich syndrome protein (N-WASP) and Arp2/3 complex, directly involved in the actin ..
  3. Hou P, Estrada L, Kinley A, Parsons J, Vojtek A, Gorski J. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum Mol Genet. 2003;12:1981-93 pubmed
    ..and begin to elucidate the molecular pathophysiology of FGDY, we demonstrate that Fgd1 directly interacts with cortactin and mouse actin-binding protein 1 (mAbp1), actin-binding proteins that regulate actin polymerization through the ..
  4. Buday L, Downward J. Roles of cortactin in tumor pathogenesis. Biochim Biophys Acta. 2007;1775:263-73 pubmed
    b>Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for the protein kinase Src...
  5. Van Damme H, Brok H, Schuuring Scholtes E, Schuuring E. The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification. J Biol Chem. 1997;272:7374-80 pubmed
    The EMS1 gene, located at the chromosome 11q13 region, is the human homologue of p80/p85 cortactin, a chicken pp60(src) tyrosine kinase substrate...
  6. Tian L, Chen L, McClafferty H, Sailer C, Ruth P, Knaus H, et al. A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J. 2006;20:2588-90 pubmed
    ..motifs target multiple SH3 domain cellular signaling proteins to BK channels, including the SH3 adapter protein cortactin (EMS1)...
  7. García Castillo J, Pedersen K, Angelini P, Bech Serra J, Colome N, Cunningham M, et al. HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation. J Biol Chem. 2009;284:25302-13 pubmed publisher
    ..The difference gel electrophoresis screening identified cortactin, a cytoskeleton-binding protein involved in the regulation of cell migration, as a phosphoprotein probably ..
  8. Katsube T, Takahisa M, Ueda R, Hashimoto N, Kobayashi M, Togashi S. Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse. J Biol Chem. 1998;273:29672-7 pubmed
    b>Cortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli...
  9. Ohoka Y, Takai Y. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Genes Cells. 1998;3:603-12 pubmed
    b>Cortactin is a major phosphotyrosyl protein in pp60v-src-transformed chicken embryo cells. Cortactin binds to actin filament (F-actin) through a unique region which consists of six tandem 37 amino acid repeats, named cortactin repeats...

More Information

Publications65

  1. Schuuring E, Van Damme H, Schuuring Scholtes E, Verhoeven E, Michalides R, Geelen E, et al. Characterization of the EMS1 gene and its product, human Cortactin. Cell Adhes Commun. 1998;6:185-209 pubmed
    ..of the EMS1 sequences with those present in the GenBank databases revealed a high identity with chicken cortactin. Southern and western blot analyses confirm the high sequence conservation during evolution...
  2. Hattan D, Nesti E, Cachero T, Morielli A. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. J Biol Chem. 2002;277:38596-606 pubmed
    ..We report that the potassium channel Kv1.2 associates with the actin-binding protein cortactin and that the binding is modulated by tyrosine phosphorylation...
  3. Clark E, Whigham A, Yarbrough W, Weaver A. Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. Cancer Res. 2007;67:4227-35 pubmed
    ..b>Cortactin is a prominent component and a specific marker of invadopodia...
  4. Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, et al. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006;103:7036-41 pubmed
    ..We also have shown that AMAP1 functions by forming a trimeric protein complex with cortactin and paxillin...
  5. Lynch D, Winata S, Lyons R, Hughes W, Lehrbach G, Wasinger V, et al. A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem. 2003;278:21805-13 pubmed
    ..The cortical actin-associated protein, cortactin, regulates the formation of dynamic actin networks via the actin-related protein (Arp)2/3 complex and hence is a ..
  6. Dudek S, Birukov K, Zhan X, Garcia J. Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem Biophys Res Commun. 2002;298:511-9 pubmed
    ..weight endothelial MLCK isoform (EC MLCK) is stably associated with a complex containing p60(src) and 80kDa cortactin, an actin-binding protein and known p60(src) target...
  7. Weed S, Parsons J. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene. 2001;20:6418-34 pubmed
    ..In this review we discuss the structure and role of the cortical actin binding protein cortactin in Rho GTPase and tyrosine kinase signaling events, with the emphasis on the roles cortactin plays in tyrosine ..
  8. Stuible M, Dubé N, Tremblay M. PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446. J Biol Chem. 2008;283:15740-6 pubmed publisher
    ..Here, we have identified cortactin, a central regulator of actin cytoskeletal dynamics, as a substrate of PTP1B...
  9. Onodera Y, Hashimoto S, Hashimoto A, Morishige M, Mazaki Y, Yamada A, et al. Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. EMBO J. 2005;24:963-73 pubmed
    ..Paxillin and cortactin have been shown to colocalize at invadopodia and play a pivotal role in breast cancer invasion...
  10. Weaver A. Cortactin in tumor invasiveness. Cancer Lett. 2008;265:157-66 pubmed publisher
    b>Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed in cancer...
  11. Kelley L, Hayes K, Ammer A, Martin K, Weed S. Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence. PLoS ONE. 2010;5:e13847 pubmed publisher
    ..The actin-binding protein cortactin is commonly upregulated in multiple cancer types and is associated with increased cell migration...
  12. Martinez Quiles N, Ho H, Kirschner M, Ramesh N, Geha R. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004;24:5269-80 pubmed
    ..by the VCA domain of WASP family members and by the acidic N-terminal and F-actin-binding repeat region of cortactin, which possesses a C-terminal SH3 domain...
  13. Le Clainche C, Pauly B, Zhang C, Engqvist Goldstein A, Cunningham K, Drubin D. A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J. 2007;26:1199-210 pubmed
    ..Here, we show that the C-terminal proline-rich domain of Hip1R binds to the SH3 domain of cortactin, a protein that binds to dynamin, actin filaments and the Arp2/3 complex...
  14. Schuuring E, Verhoeven E, Mooi W, Michalides R. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene. 1992;7:355-61 pubmed
    ..Sequence analysis of the U21C8 cDNA clone revealed no homology to known genes; we call this gene EMS1. The U21B31 cDNA clone corresponded to the 3' end of the PRAD1 proto-oncogene, recently cloned from a parathyroid ..
  15. Xu X, Garcia M, Li T, Khor L, Gajapathy R, Spittle C, et al. Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. Mod Pathol. 2010;23:187-96 pubmed publisher
    b>Cortactin is a multidomain actin-binding protein important for the functions of cytoskeleton by regulating cortical actin dynamics. It is involved in a diverse array of basic cellular functions...
  16. Wang G, Hsieh P, Hsu H, Sun G, Nieh S, Yu C, et al. Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness. World J Urol. 2009;27:557-63 pubmed publisher
    We tested the hypothesis that the expression of cortactin and survivin in renal cell carcinomas (RCCs) correlates with more advanced stages of the disease...
  17. Uruno T, Liu J, Li Y, Smith N, Zhan X. Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation. J Biol Chem. 2003;278:26086-93 pubmed
    The WASP and cortactin families constitute two distinct classes of Arp2/3 modulators in mammalian cells...
  18. Williams M, Markey J, Doczi M, Morielli A. An essential role for cortactin in the modulation of the potassium channel Kv1.2. Proc Natl Acad Sci U S A. 2007;104:17412-7 pubmed
    ..In this article, we show that the actin-binding protein cortactin regulates the potassium channel Kv1...
  19. Uruno T, Liu J, Zhang P, Fan Yx -, Egile C, Li R, et al. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol. 2001;3:259-66 pubmed
    b>Cortactin, a filamentous actin (F-actin)-associated protein and prominent substrate of Src, is implicated in progression of breast tumours through gene amplification at chromosome 11q13. However, the function of cortactin remains obscure...
  20. Jia L, Uekita T, Sakai R. Hyperphosphorylated cortactin in cancer cells plays an inhibitory role in cell motility. Mol Cancer Res. 2008;6:654-62 pubmed publisher
    b>Cortactin is frequently overexpressed in cancer cells, and changes of the levels of its tyrosine phosphorylation have been observed in several cancer cells...
  21. van Rossum A, Moolenaar W, Schuuring E. Cortactin affects cell migration by regulating intercellular adhesion and cell spreading. Exp Cell Res. 2006;312:1658-70 pubmed
    b>Cortactin is an F-actin binding protein that stabilizes F-actin networks and promotes actin polymerization by activating the Arp2/3 complex...
  22. Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng H, Rauvala H. Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J Biol Chem. 1998;273:10702-8 pubmed
    ..Western blotting reveals both c-Src and Fyn in the active fractions. In addition, cortactin, tubulin, and a 30-kDa protein are identified in the kinase-active fractions that bind to the cytosolic moiety ..
  23. Huang C, Liu J, Haudenschild C, Zhan X. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem. 1998;273:25770-6 pubmed
    b>Cortactin, a filamentous actin cross-linking protein and a substrate of Src protein tyrosine kinase, is phosphorylated at tyrosine residues upon stimulation by extracellular signals...
  24. Chuma M, Sakamoto M, Yasuda J, Fujii G, Nakanishi K, Tsuchiya A, et al. Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma. J Hepatol. 2004;41:629-36 pubmed
    ..05). Of these genes, we further investigated cortactin, because this cortical actin-associated protein is a substrate of Src, whose activation has been shown to be ..
  25. Tian L, McClafferty H, Chen L, Shipston M. Reversible tyrosine protein phosphorylation regulates large conductance voltage- and calcium-activated potassium channels via cortactin. J Biol Chem. 2008;283:3067-76 pubmed
    ..rather channel function was controlled by the tyrosine phosphorylation status of the adapter protein cortactin that assembles directly with the BK channel...
  26. Boguslavsky S, Grosheva I, Landau E, Shtutman M, Cohen M, Arnold K, et al. p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A. 2007;104:10882-7 pubmed
    ..Similar alterations in lamellipodial activity were observed in MCF-7 cells treated with siRNA to cortactin, an activator of Arp2/3-dependent actin polymerization...
  27. van Rossum A, de Graaf J, Schuuring Scholtes E, Kluin P, Fan Y, Zhan X, et al. Alternative splicing of the actin binding domain of human cortactin affects cell migration. J Biol Chem. 2003;278:45672-9 pubmed
    b>Cortactin is a filamentous actin (F-actin)-binding protein that regulates cytoskeletal dynamics by activating the Arp2/3 complex; it binds to F-actin by means of six N-terminal "cortactin repeats"...
  28. Clark E, Weaver A. A new role for cortactin in invadopodia: regulation of protease secretion. Eur J Cell Biol. 2008;87:581-90 pubmed publisher
    ..b>Cortactin, a regulator of the Arp2/3 complex, is of particular importance in invadopodia function...
  29. Luo M, Shen X, Zhang Y, Wei F, Xu X, Cai Y, et al. Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 2006;66:11690-9 pubmed
    Gain of chromosome 11q13 is a common event in esophageal squamous cell carcinoma (ESCC). The cortactin gene (CTTN, also EMS1), located at 11q13, plays a pivotal role in coupling membrane dynamics to cortical actin assembly...
  30. Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, et al. GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS ONE. 2011;6:e23359 pubmed publisher
    ..AMAP1 functions by binding to cortactin in cancer invasion and metastasis...
  31. Martin K, Jeffery E, Grigera P, Shabanowitz J, Hunt D, Parsons J. Cortactin phosphorylation sites mapped by mass spectrometry. J Cell Sci. 2006;119:2851-3 pubmed
  32. Hill A, McFarlane S, Mulligan K, Gillespie H, Draffin J, Trimble A, et al. Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells. Oncogene. 2006;25:6079-91 pubmed
    ..importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning breast cancer metastasis...
  33. Lambotin M, Hoffmann I, Laran Chich M, Nassif X, Couraud P, Bourdoulous S. Invasion of endothelial cells by Neisseria meningitidis requires cortactin recruitment by a phosphoinositide-3-kinase/Rac1 signalling pathway triggered by the lipo-oligosaccharide. J Cell Sci. 2005;118:3805-16 pubmed
    ..the activation of the ErbB2 tyrosine-kinase receptor and the Src kinase, leading to tyrosine phosphorylation of cortactin. We report here that N...
  34. Brookes S, Lammie G, Schuuring E, de Boer C, Michalides R, Dickson C, et al. Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. Genes Chromosomes Cancer. 1993;6:222-31 pubmed
    ..These map within the amplified region in UMSCC2 cells and the most telomeric corresponds to the EMS1 gene...
  35. Kempiak S, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy R, et al. A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. J Biol Chem. 2005;280:5836-42 pubmed
    ..Although cortactin has been found to synergize with N-WASP for Arp2/3-dependent actin polymerization in vitro, we find that ..
  36. Crostella L, Lidder S, Williams R, Skouteris G. Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner. Oncogene. 2001;20:3735-45 pubmed
    ..b>Cortactin, a p80/85 F-actin binding protein, was found phosphorylated on tyrosine in response to HGF-SF in A431 human ..
  37. Mizutani K, Miki H, He H, Maruta H, Takenawa T. Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res. 2002;62:669-74 pubmed
    ..of N-WASP in podosomes appears to be attributable to interaction between N-WASP and the SH3 domain of cortactin. Indeed, microinjection of the cortactin SH3 domain suppressed podosome formation...
  38. Kirkbride K, Sung B, Sinha S, Weaver A. Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr. 2011;5:187-98 pubmed
    ..signaling, cytoskeletal and membrane trafficking proteins is the Src kinase substrate and Arp2/3 binding protein cortactin. Due to its frequent overexpression in advanced, invasive cancers and its general role in regulating branched ..
  39. Mader C, Oser M, Magalhaes M, Bravo Cordero J, Condeelis J, Koleske A, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011;71:1730-41 pubmed publisher
    ..Phosphorylation of the invadopodium protein cortactin is a master switch that activates invadopodium maturation and function...
  40. Schuuring E, Verhoeven E, Litvinov S, Michalides R. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites. Mol Cell Biol. 1993;13:2891-98 pubmed
    We have previously identified two genes (EMS1 and PRAD1/cyclin D1) in the chromosome 11q13 region that are frequently coamplified and overexpressed in human breast cancer and in squamous cell carcinomas of the head and neck (E...
  41. Ren G, Helwani F, Verma S, McLachlan R, Weed S, Yap A. Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers. J Biol Chem. 2009;284:18913-22 pubmed publisher
    ..M., and Yap, A. S. (2007) Mol. Biol. Cell 18, 3214-3223). We now identify the actin-regulatory protein, cortactin, as a target of E-cadherin-activated SFK signaling...
  42. Kapus A, Di Ciano C, Sun J, Zhan X, Kim L, Wong T, et al. Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases. J Biol Chem. 2000;275:32289-98 pubmed
    ..previously that shrinkage induces Fyn-dependent tyrosine phosphorylation of the cortical actin-binding protein, cortactin. Because FER kinase was implicated in the direct phosphorylation of cortactin, we investigated the osmotic ..
  43. Folio C, Zalacain M, Zandueta C, Ormazábal C, Sierrasesumaga L, San Julian M, et al. Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. Cancer Biomark. 2011;10:35-41 pubmed publisher
    The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma...
  44. Zhang L, Tian B, Diao L, Xiong Y, Tian S, Zhang B, et al. Dominant expression of 85-kDa form of cortactin in colorectal cancer. J Cancer Res Clin Oncol. 2006;132:113-20 pubmed
    b>Cortactin is commonly expressed in several human cancers, which may alter their invasive or metastatic properties...
  45. Weaver A, Heuser J, Karginov A, Lee W, Parsons J, Cooper J. Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol. 2002;12:1270-8 pubmed
    ..Dynamic actin assembly is required for diverse cellular processes and often involves activation of Arp2/3 complex. Cortactin and N-WASp activate Arp2/3 complex, alone or in concert...
  46. Weed S, Karginov A, Schafer D, Weaver A, Kinley A, Cooper J, et al. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol. 2000;151:29-40 pubmed
    b>Cortactin is an actin-binding protein that is enriched within the lamellipodia of motile cells and in neuronal growth cones...
  47. Campbell D, Sutherland R, Daly R. Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin. Cancer Res. 1999;59:5376-85 pubmed
    The structural characteristics of EMS1 (human cortactin) suggest that it may link signaling events to reorganization of the actin cytoskeleton...
  48. Huang J, Asawa T, Takato T, Sakai R. Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma. J Biol Chem. 2003;278:48367-76 pubmed
    ..Significant tyrosine phosphorylation of cortactin, stable complex formation between activated Fyn and cortactin, and co-localization of cortactin with Fyn at cell ..
  49. Du Y, Weed S, Xiong W, Marshall T, Parsons J. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol Cell Biol. 1998;18:5838-51 pubmed
    b>Cortactin is an actin-binding protein that contains several potential signaling motifs including a Src homology 3 (SH3) domain at the distal C terminus...
  50. Bryce N, Clark E, Leysath J, Currie J, Webb D, Weaver A. Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr Biol. 2005;15:1276-85 pubmed
    ..Cells deficient in cortactin have impaired cell migration and invasion...
  51. Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez Quiles N, Backert S. Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe. 2011;9:520-31 pubmed publisher
    ..regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination...
  52. Zhao G, Huang Z, Kong Y, Wen D, Li Y, Ren L, et al. Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma. World J Surg Oncol. 2013;11:74 pubmed publisher
    b>Cortactin is an important regulator involved in invasion and migration of hepatocellular carcinoma (HCC). The aim of this study was to elucidate the forecasting role of cortactin in resectable HCCs...
  53. Bowden E, Onikoyi E, Slack R, Myoui A, Yoneda T, Yamada K, et al. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res. 2006;312:1240-53 pubmed
    ..We demonstrate that co-localization of cortactin and phosphotyrosine identifies a subset of cortactin puncta termed "invadopodial complexes" that we ..
  54. van Rossum A, Schuuring Scholtes E, van Buuren van Seggelen V, Kluin P, Schuuring E. Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain. BMC Genomics. 2005;6:15 pubmed
    In human carcinomas, overexpression of cortactin correlates with poor prognosis...
  55. Kinley A, Weed S, Weaver A, Karginov A, Bissonette E, Cooper J, et al. Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol. 2003;13:384-93 pubmed
    ..A key regulator of actin polymerization is Arp2/3 complex. Cortactin, an F-actin binding protein that localizes to membrane ruffles, is an activator of Arp2/3 complex...
  56. Wu H, Parsons J. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol. 1993;120:1417-26 pubmed
    Two related cellular proteins, p80 and p85 (cortactin), become phosphorylated on tyrosine in pp60src-transformed cells and in cells stimulated with certain growth factors...