COPS2

Summary

Gene Symbol: COPS2
Description: COP9 signalosome subunit 2
Alias: ALIEN, CSN2, SGN2, TRIP15, COP9 signalosome complex subunit 2, COP9 constitutive photomorphogenic homolog subunit 2, JAB1-containing signalosome subunit 2, TR-interacting protein 15, TRIP-15, alien homolog, signalosome subunit 2, thyroid receptor-interacting protein 15
Species: human
Products:     COPS2

Top Publications

  1. Altincicek B, Tenbaum S, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J Biol Chem. 2000;275:7662-7 pubmed
    ..We have previously characterized a novel corepressor, termed Alien, which interacts with TR and the ecdysone receptor but not with the retinoic acid receptors RAR or RXR...
  2. Seeger M, Kraft R, Ferrell K, Bech Otschir D, Dumdey R, Schade R, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998;12:469-78 pubmed
    ..It consists of at least eight different subunits including JAB1, the Jun activation-domain binding protein 1, and Trip15, the thyroid hormone receptor-interacting protein 15...
  3. Naumann M, Bech Otschir D, Huang X, Ferrell K, Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999;274:35297-300 pubmed
    ..The overexpression of signalosome subunit 2 (Sgn2), a subunit of the COP9 signalosome, leads to de novo assembly of the complex with a partial ..
  4. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell. 2003;113:357-67 pubmed
    ..Knockdown of CSN with RNA interference leads to defects in NER. These results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of NER. ..
  5. Papaioannou M, Melle C, Baniahmad A. The coregulator Alien. Nucl Recept Signal. 2007;5:e008 pubmed publisher
    b>Alien has characteristics of a corepressor for selected members of the nuclear hormone receptor (NHR) superfamily and also for transcription factors involved in cell cycle regulation and DNA repair...
  6. Lee J, Choi H, Gyuris J, Brent R, Moore D. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol. 1995;9:243-54 pubmed
  7. Yang X, Menon S, Lykke Andersen K, Tsuge T, Di Xiao -, Wang X, et al. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol. 2002;12:667-72 pubmed
    ..b>CSN2 integrates into the CSN complex via its C-terminal region and its N-terminal half region is necessary for direct ..
  8. Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech Otschir D, et al. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 2003;22:1302-12 pubmed
    ..CK2 binds to DeltaCSN3(111-403) and CSN7, whereas PKD interacts with full-length CSN3. CK2 phosphorylates CSN2 and CSN7, and PKD modifies CSN7. Both CK2 and PKD phosphorylate c-Jun as well as p53...
  9. Moehren U, Papaioannou M, Reeb C, Hong W, Baniahmad A. Alien interacts with the human androgen receptor and inhibits prostate cancer cell growth. Mol Endocrinol. 2007;21:1039-48 pubmed
    ..Here, we have characterized Alien with characteristics of a corepressor as a novel interacting factor for the antagonist bound hAR...

More Information

Publications101 found, 100 shown here

  1. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, et al. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol. 1999;19:3383-94 pubmed
    ..Here, we describe the characteristics of Alien, a novel corepressor. Alien interacts with TR only in the absence of hormone...
  2. Kapelari B, Bech Otschir D, Hegerl R, Schade R, Dumdey R, Dubiel W. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J Mol Biol. 2000;300:1169-78 pubmed
    ..The modification of COP9 signalosome subunit 2 might be essential for c-Jun phosphorylation...
  3. Wolf D, Zhou C, Wee S. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?. Nat Cell Biol. 2003;5:1029-33 pubmed
    ..This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes. ..
  4. Tenbaum S, Papaioannou M, Reeb C, Goeman F, Escher N, Kob R, et al. Alien inhibits E2F1 gene expression and cell proliferation. Biochim Biophys Acta. 2007;1773:1447-54 pubmed
    Recently, using a proteomic approach we have identified the corepressor Alien as a novel interacting factor of the cell cycle regulator E2F1...
  5. Emberley E, Mosadeghi R, Deshaies R. Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem. 2012;287:29679-89 pubmed publisher
    ..Upon consumption of substrate and subsequent deneddylation, CSN can remain stably bound to the CRL and hold it in low state of reduced activity. ..
  6. Polly P, Herdick M, Moehren U, Baniahmad A, Heinzel T, Carlberg C. VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership. FASEB J. 2000;14:1455-63 pubmed
    ..interaction of the VDR with the nuclear receptor corepressor (NCoR) and a novel corepressor, called Alien, was demonstrated to be comparable but independent of the VDR AF-2 trans-activation domain...
  7. Lyapina S, Cope G, Serino G, Tsuge T, Zhou C, Wolf D, et al. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science. 2001;292:1382-5 pubmed
  8. Moehren U, Dressel U, Reeb C, Väisänen S, Dunlop T, Carlberg C, et al. The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien. Nucleic Acids Res. 2004;32:2995-3004 pubmed
    ..Previously we have shown the interaction of Sin3A with the CoR Alien in vivo and in vitro...
  9. Min K, Kwon M, Park H, Park Y, Yoon S, Yoon J. CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun. 2005;334:867-74 pubmed
    ..Our data suggest that enhancement of CSN-mediated deneddylation by CAND1 may contribute to its function as a positive regulator of SCFs in vivo. ..
  10. Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
    ..This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. ..
  11. Lingaraju G, Bunker R, Cavadini S, Hess D, Hassiepen U, Renatus M, et al. Crystal structure of the human COP9 signalosome. Nature. 2014;512:161-5 pubmed publisher
    ..We find that neddylated CRL binding to CSN is sensed by CSN4, and communicated to CSN5 with the assistance of CSN6, resulting in activation of the deneddylase. ..
  12. Bech Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001;20:1630-9 pubmed
    ..It induces the cyclin-dependent inhibitor p21. In HeLa and MCF-7 cells, inhibition of CSN kinase by curcumin or Deltap53(145-164) results in accumulation of endogenous p53. ..
  13. Choo Y, Boh B, Lou J, Eng J, Leck Y, Anders B, et al. Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity. Mol Biol Cell. 2011;22:4706-15 pubmed publisher
    ..The deneddylating activity of CSN would subsequently promote its own dissociation to allow progression through the CRL activation cycle. ..
  14. Tsuge T, Matsui M, Wei N. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J Mol Biol. 2001;305:1-9 pubmed
    ..We demonstrated that the C-terminal half of CSN1 encompassing the PCI domain is responsible for interaction with CSN2, CSN3, and CSN4 subunits and is required for incorporation of the subunit into the complex...
  15. Huang X, Hetfeld B, Seifert U, Kahne T, Kloetzel P, Naumann M, et al. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005;272:3909-17 pubmed
    ..Flag-CSN2 was permanently expressed in mouse B8 fibroblasts and Flag pull-down experiments revealed the formation of an ..
  16. Eckey M, Hong W, Papaioannou M, Baniahmad A. The nucleosome assembly activity of NAP1 is enhanced by Alien. Mol Cell Biol. 2007;27:3557-68 pubmed
    ..Here, we show that Alien, known to harbor characteristics of a corepressor of nuclear hormone receptors such as of the vitamin D receptor (..
  17. Kob R, Baniahmad A, Escher N, von Eggeling F, Melle C. Detection and identification of transcription factors as interaction partners of alien in vivo. Cell Cycle. 2007;6:993-6 pubmed
    ..For the detection of protein-protein interactions of the corepressor Alien we used a proteomic approach comprising mass spectrometry and immunological techniques...
  18. Dong X, Zhou Z, Wang L, Saremi B, Helmbrecht A, Wang Z, et al. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:5502-5514 pubmed publisher
    ..In addition, LV1.12 upregulated abundance of CSN2 and both the abundance and promoter methylation of CSN1S1. Although LI1...
  19. Zhang M, Zhao S, Wang S, Luo C, Gao H, Zheng N, et al. d-Glucose and amino acid deficiency inhibits casein synthesis through JAK2/STAT5 and AMPK/mTOR signaling pathways in mammary epithelial cells of dairy cows. J Dairy Sci. 2018;101:1737-1746 pubmed publisher
    ..The expression levels of ?-casein and ?-casein (encoded by CSN2 and CSN3) were measured by quantitative real-time PCR and Western blotting...
  20. Laurimaa L, Süld K, Moks E, Valdmann H, Umhang G, Knapp J, et al. First report of the zoonotic tapeworm Echinococcus multilocularis in raccoon dogs in Estonia, and comparisons with other countries in Europe. Vet Parasitol. 2015;212:200-5 pubmed publisher
    The raccoon dog (Nyctereutes procyonoides) is an alien species in Europe and an important vector of zoonotic diseases...
  21. Zhou Y, Zhou Z, Peng J, Loor J. Methionine and valine activate the mammalian target of rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) and intracellular Ca2+ in bovine mammary epithelial cells. J Dairy Sci. 2018;101:11354-11363 pubmed publisher
    ..In addition, small interference RNA silencing of TAS1R1 resulted in lower β-casein (CSN2) abundance...
  22. Hou X, Hu H, Lin Y, Qu B, Gao X, Li Q. The effect of G protein-coupled receptor kinase 2 (GRK2) on lactation and on proliferation of mammary epithelial cells from dairy cows. J Dairy Sci. 2016;99:5828-5836 pubmed publisher
    ..The knockdown of GRK2 in cultured bovine mammary epithelial cells enhanced CSN2 expression and activated signaling molecules related to translation, including protein kinase B, mammalian target ..
  23. Shen Z, Mustapha A, Lin M, Zheng G. Biocontrol of the internalization of Salmonella enterica and Enterohaemorrhagic Escherichia coli in mung bean sprouts with an endophytic Bacillus subtilis. Int J Food Microbiol. 2017;250:37-44 pubmed publisher
    ..1-1.4lg CFU/g of seeds by day 5. Results of this study suggest that the source (native vs. alien) of B...
  24. Wilkins K, Prowse T, Cassey P, Thomas P, Ross J. Pest demography critically determines the viability of synthetic gene drives for population control. Math Biosci. 2018;305:160-169 pubmed publisher
    Synthetic gene drives offer a novel solution for the control of invasive alien species. CRISPR-based gene drives can positively bias their own inheritance, and comprise a DNA sequence that is replicated by homologous recombination...
  25. Negahdaripour M, Nezafat N, Hajighahramani N, Rahmatabadi S, Ghasemi Y. Investigating CRISPR-Cas systems in Clostridium botulinum via bioinformatics tools. Infect Genet Evol. 2017;54:355-373 pubmed publisher
    ..repeats (CRISPR) systems are a type of innate immunity found in some prokaryotes, which protect them against alien genetic elements by targeting foreign nucleic acids. Some other functions are also attributed to these systems...
  26. Yagdiran Y, Tallkvist J, Artursson K, Oskarsson A. Staphylococcus aureus and Lipopolysaccharide Modulate Gene Expressions of Drug Transporters in Mouse Mammary Epithelial Cells Correlation to Inflammatory Biomarkers. PLoS ONE. 2016;11:e0161346 pubmed publisher
    ..coli. The studied transporters were Bcrp, Mdr1, Mrp1, Oatp1a5, Octn1 and Oct1. In addition, Csn2, the gene encoding β-casein, was analyzed...
  27. Mirimin L, Kitchin N, Impson D, Clark P, Richard J, Daniels S, et al. Genetic and Morphological Characterization of Freshwater Shrimps (Caridina africana Kingsley, 1882) Reveals the Presence of Alien Shrimps in the Cape Floristic Region, South Africa. J Hered. 2015;106:711-8 pubmed publisher
    ..Upon removal of sequences containing NUMTs, levels of genetic diversity were low in the alien population (possibly as a consequence of a bottleneck event), while varying levels of genetic diversity and ..
  28. Mogi K, Takakuda A, Tsukamoto C, Ooyama R, Okabe S, Koshida N, et al. Mutual mother-infant recognition in mice: The role of pup ultrasonic vocalizations. Behav Brain Res. 2017;325:138-146 pubmed publisher
    ..However, controversy remains concerning whether mouse pups can distinguish between their own mother and an alien mother, and whether mothers can differentiate their own pups from alien pups...
  29. Duarte Vázquez M, García Ugalde C, Villegas Gutiérrez L, García Almendárez B, Rosado J. Production of Cow's Milk Free from Beta-Casein A1 and Its Application in the Manufacturing of Specialized Foods for Early Infant Nutrition. Foods. 2017;6: pubmed publisher
    ..This work was aimed to produce milk containing BC A2 with no BC A1 (BC A2 milk) using genetically selected CSN2 A2A2 Jersey cows...
  30. Yuan X, Wen B. Seed germination response to high temperature and water stress in three invasive Asteraceae weeds from Xishuangbanna, SW China. PLoS ONE. 2018;13:e0191710 pubmed publisher
    Crassocephalum crepidioides, Conyza canadensis, and Ageratum conyzoides are alien annuals naturalized in China, which produce a large number of viable seeds every year...
  31. Zhang R, Hou F, Feng Y, Zhang W, Zhang M, Chen P. Characterization of a Triticum aestivum-Dasypyrum villosum T2VS·2DL translocation line expressing a longer spike and more kernels traits. Theor Appl Genet. 2015;128:2415-25 pubmed publisher
    ..line has longer spikes, more spikelets and more grains per spike in two season years, which suggested that the alien segment may carry yield-related genes of D. villosum...
  32. dos Santos C, Ferreira Caliman M, Nascimento F. An alien in the group: eusocial male bees sharing nonspecific reproductive aggregations. J Insect Sci. 2015;15: pubmed publisher
    ..b>Alien males did not necessarily visit host aggregations of closely related species...
  33. Vrankovic J. Age-Related Changes in Antioxidant and Glutathione S-Transferase Enzyme Activities in the Asian Clam. Biochemistry (Mosc). 2016;81:224-32 pubmed publisher
    ..since they concern only age/size structure of the population at one locality, so more detailed studies on both the developmental stages and levels of antioxidant enzymes of this new alien species in Serbian rivers are required.
  34. Danilova T, Zhang G, Liu W, Friebe B, Gill B. Homoeologous recombination-based transfer and molecular cytogenetic mapping of a wheat streak mosaic virus and Triticum mosaic virus resistance gene Wsm3 from Thinopyrum intermedium to wheat. Theor Appl Genet. 2017;130:549-556 pubmed publisher
    ..intermedium whole-arm Robertsonian translocation T7BS·7S#3L. Whole-arm alien transfers usually suffer from linkage drag, which prevents their use in cultivar improvement...
  35. Amodeo M, Vázquez M, Zalba S. Generalist dispersers promote germination of an alien fleshy-fruited tree invading natural grasslands. PLoS ONE. 2017;12:e0172423 pubmed publisher
    ..Our results highlight the need to consider the whole seed dispersal process and the value of combining laboratory and field tests. ..
  36. Nentwig W, Pantini P, Vetter R. Distribution and medical aspects of Loxosceles rufescens, one of the most invasive spiders of the world (Araneae: Sicariidae). Toxicon. 2017;132:19-28 pubmed publisher
    ..Easily spread with transported goods, it is meanwhile an alien and invasive species to nearly all other continents and many islands...
  37. Zhu S, Ji Y, Ji J, Bie T, Gao A, He H. Fine Physical Bin Mapping of the Powdery Mildew Resistance Gene Pm21 Based on Chromosomal Structural Variations in Wheat. Int J Mol Sci. 2018;19: pubmed publisher
    ..villosum. In conclusion, this study demonstrated that physical mapping based on chromosomal structural variations is an efficient method for locating alien genes in wheat background.
  38. Patokar C, Sepsi A, Schwarzacher T, Kishii M, Heslop Harrison J. Molecular cytogenetic characterization of novel wheat-Thinopyrum bessarabicum recombinant lines carrying intercalary translocations. Chromosoma. 2016;125:163-72 pubmed publisher
    ..to both reduced linkage drag of the derived lines by minimizing agronomically deleterious genes from the alien species and high stability including transmission of the alien segment...
  39. Stabili L, Licciano M, Longo C, Lezzi M, Giangrande A. The Mediterranean non-indigenous ascidian Polyandrocarpa zorritensis: Microbiological accumulation capability and environmental implications. Mar Pollut Bull. 2015;101:146-152 pubmed publisher
    ..Thus, the potential exploitation of these filter feeders to restore polluted seawater should be taken into consideration in the management of this alien species.
  40. Li Q, Niu Z, Bao Y, Tian Q, Wang H, Kong L, et al. Transcriptome analysis of genes related to resistance against powdery mildew in wheat-Thinopyrum alien addition disomic line germplasm SN6306. Gene. 2016;590:5-17 pubmed publisher
    ..sp. tritici (Bgt), seriously damages wheat production. The wheat-Thinopyrum intermedium alien addition disomic line germplasm SN6306, being one of the important sources of genes for wheat resistance, is ..
  41. Pepori A, Bettini P, Comparini C, Sarrocco S, Bonini A, Frascella A, et al. Geosmithia-Ophiostoma: a New Fungus-Fungus Association. Microb Ecol. 2018;75:632-646 pubmed publisher
    In Europe as in North America, elms are devastated by Dutch elm disease (DED), caused by the alien ascomycete Ophiostoma novo-ulmi...
  42. Röhl O, Graupner N, Persoh D, Kemler M, Mittelbach M, Boenigk J, et al. Flooding Duration Affects the Structure of Terrestrial and Aquatic Microbial Eukaryotic Communities. Microb Ecol. 2018;75:875-887 pubmed publisher
    ..changed abiotic properties of their native habitat, and the native community may change due to the introduction of alien species...
  43. Moustakas A, Voutsela A, Katsanevakis S. Sampling alien species inside and outside protected areas: Does it matter?. Sci Total Environ. 2018;625:194-198 pubmed publisher
    Data of alien species presences are generally more readily available in protected than non-protected areas due to higher sampling efforts inside protected areas...
  44. Skrzypczak E, Babicz M, Pastwa M. Effect of Prolactin Receptor (PRLR) and Beta-Casein (CSN2) Gene Polymorphism on the Chemical Composition of Milk Sows. Folia Biol (Krakow). 2015;63:135-44 pubmed
    ..Analysis of the influence of polymorphism in the PRLR and CSN2 loci revealed that sows of the TT homozygote were characterised by the highest dry matter content...
  45. Brown P, Daigneault A. Cost-Benefit Analysis of Managing the Papuana uninodis (Coleoptera: Scarabaeidae) Taro Beetle in Fiji. J Econ Entomol. 2014;107:1866-77 pubmed publisher
    ..Papuana uninodis Prell, an invasive alien species that is native to the Solomon Islands and Vanuatu, was first reported on Viti Levu (Fiji's largest island) ..
  46. Pappalardo A, D Urso V, Viscuso R, Ferrito V, Giunta M, Cupani S, et al. Morphostructural investigation of the female reproductive system and molecular evidence for Wolbachia in Balclutha brevis Lindberg 1954 (Hemiptera, Cicadellidae). Micron. 2016;81:23-33 pubmed publisher
    ..interesting features, we carried out morphostructural investigations on the female reproductive system of this alien leafhopper...
  47. Gazol A, Zobel M, Cantero J, Davison J, Esler K, Jairus T, et al. Impact of alien pines on local arbuscular mycorrhizal fungal communities-evidence from two continents. FEMS Microbiol Ecol. 2016;92:fiw073 pubmed publisher
    The introduction of alien plants can influence biodiversity and ecosystems. However, its consequences for soil microbial communities remain poorly understood...
  48. Pickles D, King L, de Lacey S. Culturally construed beliefs and perceptions of nursing students and the stigma impacting on people living with AIDS: A qualitative study. Nurse Educ Today. 2017;49:39-44 pubmed publisher
    ..People living with HIV/AIDS were perceived as alien and assumed as homosexuals, drug users, or promiscuous. They were labelled 'bad people'...
  49. Potts S, Imperatriz Fonseca V, Ngo H, Aizen M, Biesmeijer J, Breeze T, et al. Safeguarding pollinators and their values to human well-being. Nature. 2016;540:220-229 pubmed publisher
    ..climate change, pesticides and genetically modified crops, pollinator management and pathogens, and invasive alien species. There are well-documented declines in some wild and managed pollinators in several regions of the world...
  50. Fossataro C, Bruno V, Gindri P, Pia L, Berti A, Garbarini F. Feeling touch on the own hand restores the capacity to visually discriminate it from someone else' hand: Pathological embodiment receding in brain-damaged patients. Cortex. 2018;104:207-219 pubmed publisher
    ..body ownership also affects their capacity of visually discriminating the body-identity details of the own and the alien hand, even when both hands are clearly visible on the table...
  51. Svoboda P, Lindström E, Ahmed Osman O, Langenheder S. Dispersal timing determines the importance of priority effects in bacterial communities. ISME J. 2017;: pubmed publisher
    ..Sterile medium of each origin was initially inoculated with a bacterial community of different ('alien') origin, followed by dispersal of the respective 'home' community at different time points after initial ..
  52. Liu L, Luo Q, Teng W, Li B, Li H, Li Y, et al. Development of Thinopyrum ponticum-specific molecular markers and FISH probes based on SLAF-seq technology. Planta. 2018;247:1099-1108 pubmed publisher
    ..ponticum-specific FISH probes were developed, and these markers and probes could be used for detection of alien chromatin in a wheat background...
  53. Menon S, Tsuge T, Dohmae N, Takio K, Wei N. Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem. 2008;9:1 pubmed publisher
    ..As an established component of transcription and RNA processing complexes, we hypothesis that SAP130 may link CRL mediated ubiquitination to gene expression. ..
  54. Piazza F, Aquiloni L, Peruzza L, Manfrin C, Simi S, Marson L, et al. Managing of Procambarus clarkii by X-ray sterilisation of males: Cytological damage to gonads. Micron. 2015;77:32-40 pubmed publisher
    Procambarus clarkii is an invasive alien species spreading worldwide. It is therefore mandatory to find new methods to manage this species since traditional techniques are not sufficient for this purpose...
  55. Marcantonio M, Metz M, Baldacchino F, Arnoldi D, Montarsi F, Capelli G, et al. First assessment of potential distribution and dispersal capacity of the emerging invasive mosquito Aedes koreicus in Northeast Italy. Parasit Vectors. 2016;9:63 pubmed publisher
    Invasive alien species represent a growing threat for natural systems, economy and human health...
  56. Song L, Lu Y, Zhang J, Pan C, Yang X, Li X, et al. Physical mapping of Agropyron cristatum chromosome 6P using deletion lines in common wheat background. Theor Appl Genet. 2016;129:1023-34 pubmed publisher
    ..81-1.00. This study will provide not only useful tools for characterization and utilization of wheat materials with alien chromosomal segments, but also novel wheat germplasms potentially valuable in wheat breeding and improvement.
  57. Suarez Vega A, Gutiérrez Gil B, Arranz J. Transcriptome expression analysis of candidate milk genes affecting cheese-related traits in 2 sheep breeds. J Dairy Sci. 2016;99:6381-6390 pubmed publisher
    ..Among the highly expressed genes in both breeds were the genes encoding caseins and whey proteins (CSN2, CSN3, CSN1S1, ENSOARG00000005099/PAEP, CSN1S2, LALBA), genes related to lipid metabolism (BTN1A1, XDH, FASN, ADFP, ..
  58. Agladze N, Halaidych O, Tsvelaya V, Bruegmann T, Kilgus C, Sasse P, et al. Synchronization of excitable cardiac cultures of different origin. Biomater Sci. 2017;5:1777-1785 pubmed publisher
    ..The results obtained may be considered as a proof of concept that implanted alien grafted cells are able to create electrical coupling with the host cardiac tissue.
  59. Smolnikova M, Freidin M, Tereshchenko S. The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia. Immunogenetics. 2017;69:409-413 pubmed publisher
    ..We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, ..
  60. Yi C, Wang H, Wei N, Deng X. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002;3:30 pubmed
    ..Therefore, in addition to its well-characterized role in ubiquitination, the RING finger domain may also play a structural role in nuclear import. ..
  61. Zhang J, Liu W, Lu Y, Liu Q, Yang X, Li X, et al. A resource of large-scale molecular markers for monitoring Agropyron cristatum chromatin introgression in wheat background based on transcriptome sequences. Sci Rep. 2017;7:11942 pubmed publisher
    ..Here, we reported a resource of large-scale molecular markers for tracking alien introgressions in wheat based on transcriptome sequences. By aligning A...
  62. Maroyi A. Data on introduced plants in Zimbabwe: Floristic changes and patterns of collection based on historical herbarium records. Data Brief. 2017;15:348-369 pubmed publisher
    ..Intensive collection of herbarium specimens of casual, naturalised and invasive alien plant species occurred between 1950 and 1970...
  63. Bircheneder S, Dresselhaus T. Why cellular communication during plant reproduction is particularly mediated by CRP signalling. J Exp Bot. 2016;67:4849-61 pubmed publisher
    ..parallels in downstream processes of CRP signalling in both reproduction and defence against pathogenic fungi and alien pollen tubes, with special emphasis on the role of ROS and ion channels...
  64. Padmanaba M, Tomlinson K, Hughes A, Corlett R. Alien plant invasions of protected areas in Java, Indonesia. Sci Rep. 2017;7:9334 pubmed publisher
    b>Alien plants are invading protected areas worldwide, but there is little information from tropical Asia. Java has the longest record of human occupation in Asia and today supports 145 m people...
  65. Drezen J, Josse T, Bézier A, Gauthier J, Huguet E, Herniou E. Impact of Lateral Transfers on the Genomes of Lepidoptera. Genes (Basel). 2017;8: pubmed publisher
    ..The actual extent of this phenomenon is underestimated due to frequent sequence filtering of "alien" DNA before genome assembly...
  66. Hutchison J, Cunningham S, Slessor G, Urquhart J, Smith K, Martin D. Context and Perceptual Salience Influence the Formation of Novel Stereotypes via Cumulative Cultural Evolution. Cogn Sci. 2017;: pubmed publisher
    ..We created novel alien targets by combining features from three category dimensions-color, movement, and shape-thereby creating social ..
  67. Sneller B, Roberts G. Why some behaviors spread while others don't: A laboratory simulation of dialect contact. Cognition. 2018;170:298-311 pubmed publisher
    ..study in which groups of four participants played a game that involved instant messaging in an artificial "alien language" with two dialects...
  68. McCall C, Miliani de Marval P, Chastain P, Jackson S, He Y, Kotake Y, et al. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008;28:5621-33 pubmed publisher
    ..Our studies identify a previously unknown function of VprBP in S-phase progression and suggest the possibility that HIV-1 Vpr may divert an ongoing chromosomal replication activity to facilitate viral replication. ..
  69. Enchev R, Schreiber A, Beuron F, Morris E. Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3. Structure. 2010;18:518-27 pubmed publisher
    ..We compare the structure of CSN with its homologous complexes, the 26S proteasome lid and eIF3, and propose a conserved architecture implying similar assembly pathways and/or conserved substrate interaction modes. ..
  70. Stotland A, Pruitt L, Webster P, Wolkowicz R. Purification of the COP9 signalosome complex and binding partners from human T cells. OMICS. 2012;16:312-9 pubmed publisher
    ..This proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu. ..
  71. Füzesi Levi M, Ben Nissan G, Bianchi E, Zhou H, Deery M, Lilley K, et al. Dynamic regulation of the COP9 signalosome in response to DNA damage. Mol Cell Biol. 2014;34:1066-76 pubmed publisher
    ..Taken together, our results suggest that the specific spatiotemporal composition of the CSN is highly controlled, enabling the complex to rapidly adapt and respond to DNA damage. ..
  72. Sharif T, Martell E, Dai C, Kennedy B, Murphy P, Clements D, et al. Autophagic homeostasis is required for the pluripotency of cancer stem cells. Autophagy. 2017;13:264-284 pubmed publisher
    ..Nanog homeobox) and SOX2 (SRY-box 2), and upregulated the differentiation markers TUBB3 (tubulin ? 3 class III), CSN2 (casein ?), SPP1 (secreted phosphoprotein 1), GATA6 (GATA binding protein 6), T (T brachyury transcription factor) ..
  73. Hefty A, Seybold S, Aukema B, Venette R. Cold Tolerance of Pityophthorus juglandis (Coleoptera: Scolytidae) From Northern California. Environ Entomol. 2017;46:967-977 pubmed publisher
    ..We characterized the cold tolerance of the walnut twig beetle, Pityophthorus juglandis Blackman, a domestic alien invasive bark beetle that vectors a phytopathogenic fungus...
  74. Xiang R, Macleod I, Bolormaa S, Goddard M. Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle. Sci Rep. 2017;7:9248 pubmed publisher
    ..PAEP (chr11:103 M+) and GPAT4 (chr27:36 M+) affecting protein, milk and fat yield and the other included CSN2 (chr6:87 M+), MUC1 (chr3:15.6 M), GHR (chr20:31...
  75. He F, Wang Y, Bao Y, Ma Y, Wang X, Li X, et al. Chromosomal constitutions of five wheat - Elytrigia elongata partial amphiploids as revealed by GISH, multicolor GISH and FISH. Comp Cytogenet. 2017;11:525-540 pubmed publisher
    ..10x = 70) amphiploids was employed to investigate the genomic constitution and relationships between wheat and alien chromosomes...
  76. Eckey M, Kraft F, Kob R, Escher N, Asim M, Fischer H, et al. The corepressor activity of Alien is controlled by CREB-binding protein/p300. FEBS J. 2013;280:1861-8 pubmed publisher
    ..ionization MS proteomic analysis and a yeast two-hybrid screen showed independently that the corepressor Alien interacts with the CREB-binding protein (CBP) coactivator...
  77. Rancurel C, Legrand L, Danchin E. Alienness: Rapid Detection of Candidate Horizontal Gene Transfers across the Tree of Life. Genes (Basel). 2017;8: pubmed publisher
    ..Based on the best BLAST E-values of candidate donor and recipient taxa, Alienness calculates an Alien Index (AI) for each query protein...
  78. Zhou W, Wan Y, Guo R, Deng M, Deng K, Wang Z, et al. Generation of beta-lactoglobulin knock-out goats using CRISPR/Cas9. PLoS ONE. 2017;12:e0186056 pubmed publisher
    ..01) decreased as well as other milk protein coding genes, such as CSN1S1, CSN1S2, CSN2, CSN3 and LALBA (p < 0.05). As expected, BLG protein had been abolished in the milk of the BLG knock-out goat...
  79. Novoa A, Shackleton R, Canavan S, Cybèle C, Davies S, Dehnen Schmutz K, et al. A framework for engaging stakeholders on the management of alien species. J Environ Manage. 2018;205:286-297 pubmed publisher
    b>Alien species can have major ecological and socioeconomic impacts in their novel ranges and so effective management actions are needed...
  80. Schulze Makuch D, Airo A, Schirmack J. The Adaptability of Life on Earth and the Diversity of Planetary Habitats. Front Microbiol. 2017;8:2011 pubmed publisher
    ..We use then this knowledge to outline the range of possible habitable environments for alien planets and moons and distinguish between a variety of planetary environment types...
  81. Vanbergen A, Espíndola A, Aizen M. Risks to pollinators and pollination from invasive alien species. Nat Ecol Evol. 2018;2:16-25 pubmed publisher
    Invasive alien species modify pollinator biodiversity and the services they provide that underpin ecosystem function and human well-being...
  82. Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. J Biol Chem. 2003;278:10752-62 pubmed
    ..in retinoic acid-primed neural differentiation of P19 embryonic carcinoma cells through cooperation with Trip15/CSN2, a transcriptional corepressor/component of COP9 signalosome...
  83. Fegers I, Kob R, Eckey M, Schmidt O, Goeman F, Papaioannou M, et al. The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing. J Proteome Res. 2007;6:4182-8 pubmed
    ..The corepressor Alien is involved in gene silencing mediated by selected members of nuclear hormone receptors...
  84. Sanchez M, Govignon Gion A, Croiseau P, Fritz S, Hozé C, Miranda G, et al. Within-breed and multi-breed GWAS on imputed whole-genome sequence variants reveal candidate mutations affecting milk protein composition in dairy cattle. Genet Sel Evol. 2017;49:68 pubmed publisher
    ..enrichment, including those with previously described effects on milk composition (SLC37A1, MGST1, ABCG2, CSN1S1, CSN2, CSN1S2, CSN3, PAEP, DGAT1, AGPAT6) and those with effects reported for the first time here (ALPL, ANKH, PICALM)...
  85. Lee D, Lee J, Min N, Jin J. Buckling Structured Stretchable Pseudocapacitor Yarn. Sci Rep. 2017;7:12005 pubmed publisher
    ..can successfully deposit NP on the soft SEBS surface, which is normally an unfavorable substrate for coating alien materials...
  86. Pearce C, Hayden R, Bunce C, Khanim F. Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy. BMC Cell Biol. 2009;10:31 pubmed publisher
    ..Greater than 95% knockdown of the non-catalytic subunit CSN2 and the deneddylating subunit CSN5 of the CSN was achieved in the human myeloid progenitor cell line K562...
  87. Klápště J, Suontama M, Telfer E, Graham N, Low C, Stovold T, et al. Exploration of genetic architecture through sib-ship reconstruction in advanced breeding population of Eucalyptus nitens. PLoS ONE. 2017;12:e0185137 pubmed publisher
    ..progeny tests but the method can be limited by the lack of parental genotypes and the high proportion of alien pollen from outside the breeding population...
  88. Ferro M, Lamanna J, Ripamonti M, Racchetti G, Arena A, Spadini S, et al. Functional mapping of brain synapses by the enriching activity-marker SynaptoZip. Nat Commun. 2017;8:1229 pubmed publisher
    ..encoded molecule deploying in the vesicular lumen a bait moiety designed to capture upon exocytosis a labeled alien peptide, Synbond...
  89. Nguyen T, Bajwa A, Belgeri A, Navie S, O Donnell C, Adkins S. Impact of an invasive weed, Parthenium hysterophorus, on a pasture community in south east Queensland, Australia. Environ Sci Pollut Res Int. 2017;24:27188-27200 pubmed publisher
    Parthenium weed is a highly invasive alien species in more than 40 countries around the world...
  90. Varvin S. Our Relations to Refugees: Between Compassion and Dehumanization. Am J Psychoanal. 2017;77:359-377 pubmed publisher
    ..In an environment of insecurity and collective anxiety, refugees may represent something alien and frightening but also fascinating...
  91. Bellard C, Rysman J, Leroy B, Claud C, Mace G. A global picture of biological invasion threat on islands. Nat Ecol Evol. 2017;1:1862-1869 pubmed publisher
    ..However, the lack of comprehensive information on the impacts of invasive alien species (IAS) is a problem especially on islands, where most of the recorded extinctions associated with IAS have ..
  92. Martín Vivaldi M, Soler J, Martínez García Á, Arco L, Juárez García Pelayo N, Ruiz Rodríguez M, et al. Acquisition of Uropygial Gland Microbiome by Hoopoe Nestlings. Microb Ecol. 2018;76:285-297 pubmed publisher
    ..The second experiment explored the stability of the microbiomes by inoculating glands with secretions from alien nests. The first experiment provoked a reduction in similarity of microbiomes of mother and nestlings...