COPA

Summary

Gene Symbol: COPA
Description: coatomer protein complex subunit alpha
Alias: AILJK, HEP-COP, coatomer subunit alpha, HEPCOP, alpha coat protein, alpha-COP, proxenin, xenin
Species: human
Products:     COPA

Top Publications

  1. Orcl L, Palmer D, Amherdt M, Rothman J. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993;364:732-4 pubmed
    ..COP-coated buds may therefore form essentially by self-assembly from Golgi cisternae after an initial step in which GTP is used to allow ARF binding. ..
  2. Cukierman E, Huber I, Rotman M, Cassel D. The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science. 1995;270:1999-2002 pubmed
    ..Thus, the GAP is likely to be recruited to the Golgi by an ARF1-dependent mechanism. ..
  3. Schekman R, Orci L. Coat proteins and vesicle budding. Science. 1996;271:1526-33 pubmed
    ..Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface...
  4. Pavel J, Harter C, Wieland F. Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. Proc Natl Acad Sci U S A. 1998;95:2140-5 pubmed
    ..Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner. ..
  5. Neubert M, Dahlmann E, Ambrose A, Johnson M. Copper Chaperone CupA and Zinc Control CopY Regulation of the Pneumococcal cop Operon. mSphere. 2017;2: pubmed publisher
    ..This reduced copper state is essential for bacterial copper export via CopA. In view of the fact that innate immune cells use copper to kill pathogenic bacteria, understanding the mechanisms ..
  6. Deus D, Krischek C, Pfeifer Y, Sharifi A, Fiegen U, Reich F, et al. Comparative analysis of the susceptibility to biocides and heavy metals of extended-spectrum ?-lactamase-producing Escherichia coli isolates of human and avian origin, Germany. Diagn Microbiol Infect Dis. 2017;88:88-92 pubmed publisher
    ..The genes emrE, mdfA, sugE(c), cueO, copA, zntA and zitB were commonly present in isolates with elevated MICs, while the genes qacE?1, qacF, qacH, sugE(p), ..
  7. Everson T, Lyons G, Zhang H, Soto Ramírez N, Lockett G, Patil V, et al. DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection. Genome Med. 2015;7:89 pubmed publisher
    ..as candidate loci for future studies; four were within genes with known roles in the immune response (cg04983687 in the body of ZFPM1, cg18219873 in the 5'UTR of PRG2, cg27469152 in the 3'UTR of EPX, and cg09332506 in the body of COPA).
  8. Xie P, Hao X, Herzberg M, Luo Y, Nies D, Wei G. Genomic analyses of metal resistance genes in three plant growth promoting bacteria of legume plants in Northwest mine tailings, China. J Environ Sci (China). 2015;27:179-87 pubmed publisher
    ..Meanwhile, the putative CopA/CueO system is expected to mediate copper resistance in Sinorhizobium meliloti CCNWSX0020 while ZntA transporter, ..
  9. Knafo S, Wyart C. Active mechanosensory feedback during locomotion in the zebrafish spinal cord. Curr Opin Neurobiol. 2018;52:48-53 pubmed publisher
    ..Sensory gating, either through inhibition of sensory interneurons (CoPA) or though the direct inhibition of primary motor neurons by CSF-cNs, mediates postural control...

More Information

Publications139 found, 100 shown here

  1. Kang Y, Lee W, Jang G, Kim B, Yoon Y. Modulating the sensing properties of Escherichia coli-based bioreporters for cadmium and mercury. Appl Microbiol Biotechnol. 2018;102:4863-4872 pubmed publisher
    ..Moreover, the sensitivity toward both Cd(II) and Hg(II) was enhanced when copA, which is known to export copper and silver, was deleted...
  2. Grillo Puertas M, Schurig Briccio L, Rodríguez Montelongo L, Rintoul M, Rapisarda V. Copper tolerance mediated by polyphosphate degradation and low-affinity inorganic phosphate transport system in Escherichia coli. BMC Microbiol. 2014;14:72 pubmed publisher
    ..In exponential phase, CopA and polyP-Pit system would act simultaneously to detoxify the metal or one could be sufficient to safeguard the ..
  3. Lim A, Moussavi Nik S, Ebrahimie E, Lardelli M. Analysis of nicastrin gene phylogeny and expression in zebrafish. Dev Genes Evol. 2015;225:171-8 pubmed publisher
    ..The analysis of synteny conservation revealed local rearrangements of ncstn and another gene, mpz, relative to copa, and pex19...
  4. Montaseri S. Fast prediction of RNA-RNA interaction using heuristic algorithm. Methods Mol Biol. 2015;1269:123-33 pubmed publisher
    ..The proposed algorithm has been performed on some datasets including CopA-CopT, R1inv-R2inv, Tar-Tar*, DIS-DIS, and IncRNA54-RepZ in Escherichia coli bacteria...
  5. Shallev L, Kopel E, Feiglin A, Leichner G, Avni D, Sidi Y, et al. Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis. RNA. 2018;24:828-840 pubmed publisher
    ..the global alteration, we also detect editing changes in functional recoding sites located in the IGFBP7, COPA, and FLNA genes...
  6. Gracioso L, Baltazar M, Avanzi I, Karolski B, Oller Nascimento C, Perpetuo E. Analysis of copper response in Acinetobacter sp. by comparative proteomics. Metallomics. 2019;: pubmed publisher
    ..The proteins were identified to be associated with the glycolytic pathway, membrane transport, biosynthesis and two proteins directly involved in copper homeostasis (CopA and CopB).
  7. Peng X, Xu X, Wang Y, Hawke D, Yu S, Han L, et al. A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Cancer Cell. 2018;33:817-828.e7 pubmed publisher
    ..We validate the presence of editing events at both RNA and protein levels. The edited COPA protein increases proliferation, migration, and invasion of cancer cells in vitro...
  8. Melki I, Crow Y. Novel monogenic diseases causing human autoimmunity. Curr Opin Immunol. 2015;37:1-5 pubmed publisher
    ..Here we discuss a selection of these diseases due to mutations in PRKCD, CTLA4, STAT3, IFIH1, TMEM173 and COPA.
  9. Gourdon P, Liu X, Skjørringe T, Morth J, Møller L, Pedersen B, et al. Crystal structure of a copper-transporting PIB-type ATPase. Nature. 2011;475:59-64 pubmed publisher
    ..Here we present the structure of a PIB-ATPase, a Legionella pneumophila CopA Cu(+)-ATPase, in a copper-free form, as determined by X-ray crystallography at 3.2 Å resolution...
  10. Padilla Benavides T, George Thompson A, McEvoy M, ARGUELLO J. Mechanism of ATPase-mediated Cu+ export and delivery to periplasmic chaperones: the interaction of Escherichia coli CopA and CusF. J Biol Chem. 2014;289:20492-501 pubmed publisher
    ..Cytosolic Cu(+) chaperones (CopZ) interact with a structural platform in Cu(+)-ATPases (CopA) and deliver copper into the ion permeation path...
  11. Hernández González M, Bravo Plaza I, de los Ríos V, Pinar M, Pantazopoulou A, Peñalva M. COPI localizes to the early Golgi in Aspergillus nidulans. Fungal Genet Biol. 2019;123:78-86 pubmed publisher
    ..2007) with the α-COP/CopA subunit of COPI...
  12. Zeng X, Zhang M, Liu Y, Tang W. Manganese(II) oxidation by the multi-copper oxidase CopA from Brevibacillus panacihumi MK-8. Enzyme Microb Technol. 2018;117:79-83 pubmed publisher
    ..In this study, we identified a new manganese(II) oxidase (CopA) from Brevibacillus panacihumi MK-8...
  13. Zarkou A, Lee S, Prosser L, Hwang S, Jeka J. Stochastic resonance stimulation improves balance in children with cerebral palsy: a case control study. J Neuroeng Rehabil. 2018;15:115 pubmed publisher
    ..velocity (COPV) in anteroposterior (A/P) and medial-lateral (M/L) direction, 95% COP confidence ellipse area (COPA), and A/P and M/L root mean square (RMS) measures were computed and compared...
  14. Granja Travez R, Bugg T. Characterization of multicopper oxidase CopA from Pseudomonas putida KT2440 and Pseudomonas fluorescens Pf-5: Involvement in bacterial lignin oxidation. Arch Biochem Biophys. 2018;660:97-107 pubmed publisher
    b>CopA is a protein formed as part of a copper resistance operon in Pseudomonas syringae pv tomato, but CopA has also been identified from gene library screening as a potential lignin-oxidising enzyme...
  15. Wice B, Reeds D, Tran H, Crimmins D, Patterson B, Dunai J, et al. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. 2012;61:1793-800 pubmed publisher
    ..This response is blunted in type 2 diabetes (T2DM). Xenin-25 is a 25-amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS in hyperglycemic mice...
  16. Wice B, Wang S, Crimmins D, Diggs Andrews K, Althage M, Ford E, et al. Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism. J Biol Chem. 2010;285:19842-53 pubmed publisher
    ..Pharmacologic doses of xenin-25, another peptide produced by K cells, restored the GIP-mediated insulin secretory response and reduced ..
  17. Hasib A, Ng M, Khan D, Gault V, Flatt P, Irwin N. A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice. Peptides. 2018;100:202-211 pubmed publisher
    ..receptors including, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established benefits for the treatment of diabetes...
  18. Liu K, Sun M, Ye M, Chao H, Zhao Y, Xia B, et al. Coexistence and association between heavy metals, tetracycline and corresponding resistance genes in vermicomposts originating from different substrates. Environ Pollut. 2019;244:28-37 pubmed publisher
    ..Cu), zinc (Zn), cadmium (Cd), corresponding TC-resistance genes (tetA, tetC, tetW, tetM, tetO, and tetS) and HRGs (copA, pcoA, cusA, czcA, czcB, and czcR) in the three vermicompost samples...
  19. Toulouse C, Metesch K, Pfannstiel J, Steuber J. Metabolic Reprogramming of Vibrio cholerae Impaired in Respiratory NADH Oxidation Is Accompanied by Increased Copper Sensitivity. J Bacteriol. 2018;200: pubmed publisher
    ..Most unexpected, the copper resistance proteins CopA, CopG, and CueR were decreased in the nqr deletion strain...
  20. Fu Y, Bruce K, Wu H, Giedroc D. The S2 Cu(i) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance. Metallomics. 2016;8:61-70 pubmed publisher
    ..encodes an obligatorily membrane-anchored Cu(i) binding protein, CupA, and a P1B-type ATPase efflux transporter, CopA. The soluble, cytoplasmic domain of CupA (sCupA) contains a binuclear Cu(i) cluster consisting of S1 and S2 Cu(i) ..
  21. Hasib A, Ng M, Khan D, Gault V, Flatt P, Irwin N. Characterisation and antidiabetic utility of a novel hybrid peptide, exendin-4/gastrin/xenin-8-Gln. Eur J Pharmacol. 2018;834:126-135 pubmed publisher
    ..hormones such as glucagon-like-peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), gastrin and xenin are known to exert complementary beneficial metabolic effects in diabetes...
  22. Kay K, Hamilton C, Le Brun N. Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol. J Inorg Biochem. 2018;190:24-30 pubmed publisher
    b>CopA is a Cu(I)-exporting transmembrane P1B-type ATPase from Bacillus subtilis...
  23. Hao X, Xie P, Zhu Y, Taghavi S, Wei G, Rensing C. Copper tolerance mechanisms of Mesorhizobium amorphae and its role in aiding phytostabilization by Robinia pseudoacacia in copper contaminated soil. Environ Sci Technol. 2015;49:2328-40 pubmed publisher
    ..in copper resistance were identified through transposon mutagenesis, including genes encoding a P-type ATPase (CopA), hypothetical proteins, and other proteins (a GTP-binding protein and a ribosomal protein)...
  24. McCormick D, Lin Y, Grey F. Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen. MBio. 2018;9: pubmed publisher
    ..Knockdown of the top candidates, ERC1, RAB4B, COPA, and COPB2, caused profound loss of virus production...
  25. Furnholm T, Tisa L. The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia. BMC Genomics. 2014;15:1092 pubmed publisher
    ..Gene duplication and amino acid substitutions that enhanced the metal affinity of CopA and CopCD proteins may be responsible for the copper resistance found in some Frankia strains...
  26. Chihomvu P, Stegmann P, Pillay M. Characterization and structure prediction of partial length protein sequences of pcoA, pcoR and chrB genes from heavy metal resistant bacteria from the Klip River, South Africa. Int J Mol Sci. 2015;16:7352-74 pubmed publisher
    ..Open reading frames (ORFs) related to the genes CopA and CopR were identified in E. coli KR29, PcoA in Lysinibacillus sp...
  27. Singh K, Senadheera D, Lévesque C, Cvitkovitch D. The copYAZ Operon Functions in Copper Efflux, Biofilm Formation, Genetic Transformation, and Stress Tolerance in Streptococcus mutans. J Bacteriol. 2015;197:2545-57 pubmed publisher
    ..Most Gram-positive bacteria utilize the copYABZ operon for copper homeostasis, where copA and copB encode copper-transporting P-type ATPases, whereas copY and copZ regulate the expression of the cop operon...
  28. Bhavya S, Lew P, Mizuno T. Central action of xenin affects the expression of lipid metabolism-related genes and proteins in mouse white adipose tissue. Neuropeptides. 2017;63:67-73 pubmed publisher
    b>Xenin is a gastrointestinal hormone that reduces food intake when administered centrally and it has been hypothesized that central action of xenin participates in the regulation of whole-body metabolism...
  29. Knogler L, Drapeau P. Sensory gating of an embryonic zebrafish interneuron during spontaneous motor behaviors. Front Neural Circuits. 2014;8:121 pubmed publisher
    ..neurons fire in response to mechanical stimuli and excite downstream glutamatergic commissural primary ascending (CoPA) interneurons to produce a flexion response contralateral to the site of stimulus...
  30. Navarro C, von Bernath D, Martínez Bussenius C, Castillo R, Jerez C. Cytoplasmic CopZ-Like Protein and Periplasmic Rusticyanin and AcoP Proteins as Possible Copper Resistance Determinants in Acidithiobacillus ferrooxidans ATCC 23270. Appl Environ Microbiol. 2016;82:1015-1022 pubmed publisher
    ..A. ferrooxidans contains canonical copper resistance determinants present in other bacteria, such as CopA ATPases and RND efflux pumps, but these components do not entirely explain its high metal tolerance...
  31. Bensellam M, Maxwell E, Chan J, Luzuriaga J, West P, Jonas J, et al. Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells. Diabetologia. 2016;59:1492-1502 pubmed publisher
    ..Coatomer protein complex genes (Copa, Cope, Copg [also known as Copg1], Copz1 and Copz2) and ER-to-Golgi protein trafficking were also reduced, whereas ..
  32. Kernberger Fischer I, Krischek C, Strommenger B, Fiegen U, Beyerbach M, Kreienbrock L, et al. Susceptibility of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Various Clonal Lineages from Germany to Eight Biocides. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..i>sepA (n = 22), mco (n = 5), czrC (n = 3), smr (n = 2), copA (n = 1), qacA and/or -B (n = 1), qacG (n = 2), and qacJ (n
  33. Yuan Q, Zhai Y, Mao B, Hu N. Antibiotic resistance genes and intI1 prevalence in a swine wastewater treatment plant and correlation with metal resistance, bacterial community and wastewater parameters. Ecotoxicol Environ Saf. 2018;161:251-259 pubmed publisher
    ..livestock wastewater treatment plant, and analyzed their integrated association with two metal resistance genes (copA and czcA), two pathogens genes (Staphylococcus and Campylobacter), bacterial community and wastewater properties...
  34. Gardner S, Olson J. Interaction of Copper Toxicity and Oxidative Stress in Campylobacter jejuni. J Bacteriol. 2018;200: pubmed publisher
    ..jejuni (termed CopA and CueO) have been shown to be a copper transporter and multicopper oxidase, respectively...
  35. Kang W, Zhang Y, Shi X, He J, Hu H. Short-term copper exposure as a selection pressure for antibiotic resistance and metal resistance in an agricultural soil. Environ Sci Pollut Res Int. 2018;25:29314-29324 pubmed publisher
    ..The two Cu resistance genes (copA and pcoR) were highly enriched in low-level Cu treatment (50 and 100 mg kg-1), and their abundances ..
  36. Takaishi K, Kawahito S, Tomioka S, Eguchi S, Kitahata H. Cuffed oropharyngeal airway for difficult airway management. Anesth Prog. 2014;61:107-10 pubmed publisher
    ..We therefore decided to perform retrograde intubation and selected the cuffed oropharyngeal airway (COPA) for airway management...
  37. Chaplin A, Tan B, Vijgenboom E, Worrall J. Copper trafficking in the CsoR regulon of Streptomyces lividans. Metallomics. 2015;7:145-55 pubmed publisher
    ..transcriptional derepression of genes encoding for copper efflux systems involving CopZ-like copper chaperones and CopA-like P-type ATPases. Whether CsoR obtains copper via a protein-protein mediated trafficking mechanism is unknown...
  38. Hara Y, Obata Y, Horikawa K, Tasaki Y, Suzuki K, Murata T, et al. M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells. PLoS ONE. 2017;12:e0175514 pubmed publisher
    ..Here, we show a strategy for inhibition of the Kit-PI3K-Akt pathway in neoplastic mast cells by M-COPA (2-methylcoprophilinamide), an inhibitor of this secretory pathway...
  39. Koudelka S, Voas M, Almeida R, Baraban M, Soetaert J, Meyer M, et al. Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release. Curr Biol. 2016;26:1447-55 pubmed publisher
    ..We find that the axons of reticulospinal and commissural primary ascending (CoPA) neurons are among the first myelinated in the zebrafish CNS...
  40. Johnson M, Kehl Fie T, Klein R, Kelly J, Burnham C, Mann B, et al. Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance. Infect Immun. 2015;83:1684-94 pubmed publisher
    ..Deletion of either the exporter, encoded by copA, or the chaperone, encoded by cupA, led to hypersensitivity to copper stress...
  41. Drees S, Beyer D, Lenders Lomscher C, Lübben M. Distinct functions of serial metal-binding domains in the Escherichia coli P1 B -ATPase CopA. Mol Microbiol. 2015;97:423-38 pubmed publisher
    ..Within this study, the roles of the two adjacent metal-binding domains (MBDs) of CopA, the copper export ATPase of Escherichia coli were investigated...
  42. Kim E, Lew P, Spirkina A, Mizuno T. Xenin-induced feeding suppression is not mediated through the activation of central extracellular signal-regulated kinase signaling in mice. Behav Brain Res. 2016;312:118-26 pubmed publisher
    b>Xenin is a gut hormone that reduces food intake by partly acting through the hypothalamus via neurotensin receptor 1 (Ntsr1). However, specific signaling pathways that mediate xenin-induced feeding suppression are not fully understood...
  43. Fu Y, Tsui H, Bruce K, Sham L, Higgins K, Lisher J, et al. A new structural paradigm in copper resistance in Streptococcus pneumoniae. Nat Chem Biol. 2013;9:177-83 pubmed publisher
    ..resistance is mediated by the copper-responsive repressor CopY, CupA and the copper-effluxing P(1B)-type ATPase CopA. We show here that CupA is a previously uncharacterized cell membrane-anchored Cu(I) chaperone and that a Cu(I) ..
  44. Teng F, Guo M, Liu F, Wang C, Dong J, Zhang L, et al. Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas. Oncotarget. 2016;7:53571-53582 pubmed publisher
    ..In this study, we performed a meta-Cancer Outlier Profile Analysis (meta-COPA) across six microarray datasets for HCC from the GEO database...
  45. Bharadwaj S, Mitchell R, Qureshi A, Niazi J. Toxicity evaluation of e-juice and its soluble aerosols generated by electronic cigarettes using recombinant bioluminescent bacteria responsive to specific cellular damages. Biosens Bioelectron. 2017;90:53-60 pubmed publisher
    ..controlled by promoters that specifically induced to DNA damage (recA), superoxide radicals (sodA), heavy metals (copA) and membrane damage (oprF)...
  46. Pietri T, Manalo E, Ryan J, Saint Amant L, Washbourne P. Glutamate drives the touch response through a rostral loop in the spinal cord of zebrafish embryos. Dev Neurobiol. 2009;69:780-95 pubmed publisher
    ..This rostral sensory connection is presumably established via CoPA interneurons, as they project to the rostral spinal cord...
  47. Sun S, Purdy A, Walsh G. Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance. BMC Neurosci. 2016;17:83 pubmed
    ..born spinal commissural neuron to navigate the midline and turn rostrally is termed commissural primary ascending (CoPA)...
  48. Scala S, Giuliano P, Ascierto P, Ierano C, Franco R, Napolitano M, et al. Human melanoma metastases express functional CXCR4. Clin Cancer Res. 2006;12:2427-33 pubmed
    ..Metastatic melanoma cell lines expressed cell surface CXCR4; PES 43, Alo 40, and COPA cell lines showed the highest levels of CXCR4 (>90% of positive cells); PES 41, Alo 39, PES 47, POAG, and CIMA ..
  49. Kirker K, Fisher S, James G, McGhee D, Shah C. Efficacy of Polyhexamethylene Biguanide-containing Antimicrobial Foam Dressing Against MRSA Relative to Standard Foam Dressing. Wounds. 2009;21:229-33 pubmed
    ..antimicrobial foam (Kendallâ„¢ AMD, Covidien, Mansfield, MA), which contains PHMB and a standard foam dressing (Copaâ„¢, Covidien, Mansfield, MA), which contains no PHMB (control), were directly inoculated with clinical isolate ..
  50. Gillan D. Metal resistance systems in cultivated bacteria: are they found in complex communities?. Curr Opin Biotechnol. 2016;38:123-30 pubmed publisher
    ..sulfide production (dsr genes), resistance mediated in the periplasm (CopK and multicopper oxidases such as PcoA/CopA), efflux proteins (HME-RND systems, P-type ATPases, and the cation diffusion facilitator CzcD) as well as proteins ..
  51. Raven R. A revision of ant-mimicking spiders of the family Corinnidae (Araneae) in the Western Pacific. Zootaxa. 2015;3958:1-258 pubmed publisher
    ..The Castianeirinae from the Western Pacific including Australia includes Battalus Karsch, 1878, Copa Simon, 1886, Leichhardteus Raven & Baehr, 2013, Nyssus Walckenaer, 1805, Poecilipta Simon, 1897, and eight new ..
  52. Feßler A, Zhao Q, Schoenfelder S, Kadlec K, Brenner Michael G, Wang Y, et al. Complete sequence of a plasmid from a bovine methicillin-resistant Staphylococcus aureus harbouring a novel ica-like gene cluster in addition to antimicrobial and heavy metal resistance genes. Vet Microbiol. 2017;200:95-100 pubmed publisher
    ..In addition, the cadmium resistance operon cadDX as well as the copper resistance genes copA and mco were located on the plasmid and mediated a reduced susceptibility to cadmium and copper...
  53. Worthen Chaudhari L, Monfort S, Bland C, Pan X, Chaudhari A. Characterizing within-subject variability in quantified measures of balance control: A cohort study. Gait Posture. 2018;64:141-146 pubmed publisher
    ..square amplitude of medial-lateral COP during QEC (RMSml); (secondary) WSV95 of COP ellipse area (COPa); (secondary) WSV95 of mean medial-lateral COP velocity (COPvml) during QEC...
  54. Iglesias Gato D, Wikström P, Tyanova S, Lavallee C, Thysell E, Carlsson J, et al. The Proteome of Primary Prostate Cancer. Eur Urol. 2016;69:942-52 pubmed publisher
    ..such as carnitine palmitoyltransferase 2 (CPT2, fatty acid transporter), coatomer protein complex, subunit alpha (COPA, vesicle secretion), and mitogen- and stress-activated protein kinase 1 and 2 (MSK1/2, protein kinase) regulate the ..
  55. Wong H, White R, Visscher P, Charlesworth J, Vázquez Campos X, Burns B. Disentangling the drivers of functional complexity at the metagenomic level in Shark Bay microbial mat microbiomes. ISME J. 2018;12:2619-2639 pubmed publisher
    ..methanogenesis (hdrABC), Wood-Ljungdahl pathways (cooS, coxSML), phosphate transport (pstB), and copper efflux (copA)...
  56. Gaimster H, Summers D. Plasmids in the driving seat: The regulatory RNA Rcd gives plasmid ColE1 control over division and growth of its E. coli host. Plasmid. 2015;78:59-64 pubmed publisher
    ..Non-coding RNAs, such as CopA and Sok from plasmid R1, or RNAI from ColE1, exerted regulation by refolding the secondary structures of their ..
  57. de Almeida Borges V, da Silva J, Barbosa S, Nasciutti L, Cabral L, de Sousa V. Development and pharmacological evaluation of in vitro nanocarriers composed of lamellar silicates containing copaiba oil-resin for treatment of endometriosis. Mater Sci Eng C Mater Biol Appl. 2016;64:310-317 pubmed publisher
    ..The nanocomposites in this study were obtained from the reaction of copaiba oil-resin (COPA) with the polymer polyvinylpyrrolidone (PVP K-30)...
  58. Kociucka B, Jackowiak H, Kamyczek M, Szydlowski M, Szczerbal I. The relationship between adipocyte size and the transcript levels of SNAP23, BSCL2 and COPA genes in pigs. Meat Sci. 2016;121:12-18 pubmed publisher
    ..subcutaneous, visceral and longissimus dorsi muscle) in relation to transcript levels of genes (SNAP23, BSCL2 and COPA), which encode proteins involved in lipid droplet formation...
  59. Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen M. Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1-1 plasmid. BMC Microbiol. 2018;18:27 pubmed publisher
    ..The plasmid carries the repA, tap, copA and bla genes, and genes for ORF1 and ORF2. MiniR1-1 contains eight DnaA-binding sites (DnaA-boxes)...
  60. Young C, Gordon L, Fang Z, Holder R, Reid S. Copper Tolerance and Characterization of a Copper-Responsive Operon, copYAZ, in an M1T1 Clinical Strain of Streptococcus pyogenes. J Bacteriol. 2015;197:2580-92 pubmed publisher
    ..pyogenes protects itself against copper toxicity. We defined a set of putative genes, copY (for a regulator), copA (for a P1-type ATPase), and copZ (for a copper chaperone), whose expression is regulated by copper...
  61. Bredeston L, González Flecha F. The promiscuous phosphomonoestearase activity of Archaeoglobus fulgidus CopA, a thermophilic Cu+ transport ATPase. Biochim Biophys Acta. 2016;1858:1471-8 pubmed publisher
    ..study, we characterize the phosphatase activity of the Cu(+)-transport ATPase from Archaeglobus fulgidus (Af-CopA) and compare it with the principal ATPase activity...
  62. Zhang Q, Wang J, Yu J, Guo Z. Improved electrical conductivity of TPU/carbon black composites by addition of COPA and selective localization of carbon black at the interface of sea-island structured polymer blends. Soft Matter. 2017;13:3431-3439 pubmed publisher
    ..CB) in thermoplastic polyurethane (TPU) decreases by 46% with the incorporation of 20 wt% polyamide copolymer (COPA) through selective localization of CB particles at the interface of sea-island structured TPU/COPA blends...
  63. Soto D, Recalde A, Orell A, Albers S, Paradela A, Navarro C, et al. Global effect of the lack of inorganic polyphosphate in the extremophilic archaeon Sulfolobus solfataricus: A proteomic approach. J Proteomics. 2019;191:143-152 pubmed publisher
    ..The polyP deficient strain showed an increased copper sensitivity and an earlier transcriptional up-regulation of copA gene coding for the P-type copper-exporting ATPase...
  64. Park S, Yoo S, Ha S. Comparison of Ocular Pulse Amplitude-Lowering Effects of Tafluprost and Latanoprost by Dynamic Contour Tonometry. J Ocul Pharmacol Ther. 2015;31:617-22 pubmed publisher
    ..measured by Goldmann applanation tonometry (GAT), OPA was measured by dynamic contour tonometry, and corrected OPA (cOPA) was calculated before and after 1 week, 1-3 months of treatment. Initial IOP and OPA were 17.12 ± 3.75, 2...
  65. Gault M, Effantin G, Rodrigue A. Ni exposure impacts the pool of free Fe and modifies DNA supercoiling via metal-induced oxidative stress in Escherichia coli K-12. Free Radic Biol Med. 2016;97:351-361 pubmed publisher
    ..The content of Cu was not significantly affected upon the addition of Ni to the growth medium, nor were the Cus and CopA Cu-efflux systems important for the survival of bacteria under Ni stress In contrast the addition of Ni slightly ..
  66. Haddad C. Taxonomic notes on the spider genus Messapus Simon, 1898 (Araneae, Corinnidae), with the description of the new genera Copuetta and Wasaka and the first cladistic analysis of Afrotropical Castianeirinae. Zootaxa. 2013;3688:1-79 pubmed publisher
    ..nov., which is redescribed from both sexes and transferred from Copa Simon, 1885. A further eleven new species of Copuetta are described: C. comorica sp. nov., C. erecta sp. nov., C...
  67. Seo D, Ha S. Comparison of Ocular Pulse Amplitude Lowering Effects of Preservative-Free Tafluprost and Preservative-Free Dorzolamide-Timolol Fixed Combination Eyedrops. Biomed Res Int. 2015;2015:435874 pubmed publisher
    ..OPA was measured using dynamic contour tonometry; corrected OPA (cOPA) was calculated at baseline and at 1 week and 1, 3, and 6 months after treatment...
  68. Kociucka B, Flisikowska T, Mróz D, Szczerbal I. Expression of genes involved in lipid droplet formation (BSCL2, SNAP23 and COPA) during porcine in vitro adipogenesis. J Appl Genet. 2016;57:505-510 pubmed
    ..In the present study, expression of three genes involved in lipid droplet formation (SNAP23, BSCL2 and COPA) was evaluated during porcine adipogenesis...
  69. Ohashi Y, Okamura M, Hirosawa A, Tamaki N, Akatsuka A, Wu K, et al. M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers. Cancer Res. 2016;76:3895-903 pubmed publisher
    ..The small-molecule compound M-COPA [2-methylcoprophilinamide (AMF-26)] disrupts the Golgi apparatus by inhibiting the activation of Arf1, resulting in ..
  70. Dorshorst B, Henegar C, Liao X, Sällman Almén M, Rubin C, Ito S, et al. Dominant Red Coat Color in Holstein Cattle Is Associated with a Missense Mutation in the Coatomer Protein Complex, Subunit Alpha (COPA) Gene. PLoS ONE. 2015;10:e0128969 pubmed publisher
    ..Here we show that a missense mutation in the coatomer protein complex, subunit alpha (COPA), a gene with previously no known role in pigmentation synthesis, is completely associated with Dominant Red in ..
  71. Parthsarathy V, Irwin N, Hasib A, Martin C, McClean S, Bhat V, et al. A novel chemically modified analogue of xenin-25 exhibits improved glucose-lowering and insulin-releasing properties. Biochim Biophys Acta. 2016;1860:757-64 pubmed publisher
    b>Xenin-25 is a K-cell derived gut peptide with insulin-releasing activity which is rapidly degraded following release into the circulation...
  72. Hasib A, Ng M, Gault V, Khan D, Parthsarathy V, Flatt P, et al. An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice. Diabetologia. 2017;60:541-552 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) and xenin, regulatory gut hormones secreted from enteroendocrine K cells, exert important effects on metabolism. In addition, xenin potentiates the biological actions of GIP...
  73. Uchida H, Matsumura S, Okada S, Suzuki T, Minami T, Ito S. RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury. FASEB J. 2017;31:1847-1855 pubmed publisher
    ..5-hydroxytryptamine) 2C receptor (5-HT2CR), at the I/V site of coatomer protein complex subunit ? (COPA), and at the R/G site of AMPA receptor subunit GluA2 in the injured DRG...
  74. Ladomersky E, Khan A, Shanbhag V, Cavet J, Chan J, Weisman G, et al. Host and Pathogen Copper-Transporting P-Type ATPases Function Antagonistically during Salmonella Infection. Infect Immun. 2017;85: pubmed publisher
    ..Deletion of the S Typhimurium copper exporters, CopA and GolT, was found to decrease infection in wild-type mice but not in the Atp7aLysMcre ..
  75. Hattori T, Watanabe Takahashi M, Shiina I, Ohashi Y, Dan S, Nishikawa K, et al. M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin. Genes Cells. 2016;21:901-6 pubmed publisher
    ..We report here that 2-methylcoprophilinamide (M-COPA), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), ..
  76. Djoko K, Phan M, Peters K, Walker M, Schembri M, McEwan A. Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proc Natl Acad Sci U S A. 2017;114:6818-6823 pubmed publisher
    ..The Cu tolerance system in Gram-negative bacteria is composed minimally of a Cu sensor (CueR) and a Cu export pump (CopA)...
  77. Gholamrezazadeh M, Shakibaie M, Monirzadeh F, Masoumi S, Hashemizadeh Z. Effect of nano-silver, nano-copper, deconex and benzalkonium chloride on biofilm formation and expression of transcription regulatory quorum sensing gene (rh1R) in drug-resistance Pseudomonas aeruginosa burn isolates. Burns. 2018;44:700-708 pubmed publisher
    ..Polymerase chain reaction (PCR) was used for detection of qacEΔ1, cepA, copA and rhlR genes...
  78. Bachman M, Breen P, Deornellas V, Mu Q, Zhao L, Wu W, et al. Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection. MBio. 2015;6:e00775 pubmed publisher
    ..acids that are essential in mice and humans, the transcriptional elongation factor RfaH, and the copper efflux pump CopA. The majority of fitness genes were conserved among reference strains representative of diverse pathotypes...
  79. Maryanovich A, Kormilets D, Polyanovsky A. Xenin: the oldest after insulin?. Mol Biol Rep. 2018;45:143-150 pubmed publisher
    b>Xenin is a regulatory peptide first isolated from the human gastric mucosa...
  80. Bhavya S, Lew P, Mizuno T. Stimulation of white adipose tissue lipolysis by xenin, a neurotensin-related peptide. Biochem Biophys Res Commun. 2018;498:842-848 pubmed publisher
    b>Xenin is a gastrointestinal hormone that belongs to the neurotensin family...
  81. de Jesus A, Goldbach Mansky R. Newly recognized Mendelian disorders with rheumatic manifestations. Curr Opin Rheumatol. 2015;27:511-9 pubmed publisher
    ..Mutations in ADA2, TRNT1 and COPA, AP1S3, and TNFRSF11A cause complex syndromes; loss-of-function mutations in enzymes and molecules are linked to ..
  82. Bütof L, Wiesemann N, Herzberg M, Altzschner M, Holleitner A, Reith F, et al. Synergistic gold-copper detoxification at the core of gold biomineralisation in Cupriavidus metallidurans. Metallomics. 2018;10:278-286 pubmed publisher
    ..methods we show that inducible resistance to these Cu/Au mixtures is mediated by the periplasmic Cu(i)-oxidase CopA, which functions as an oxygen-consuming Au(i)-oxidase...
  83. Durand A, Azzouzi A, Bourbon M, Steunou A, Liotenberg S, Maeshima A, et al. c-Type Cytochrome Assembly Is a Key Target of Copper Toxicity within the Bacterial Periplasm. MBio. 2015;6:e01007-15 pubmed publisher
    ..Central to these systems, the Cu(+) ATPase CopA plays a major role in copper tolerance and translocates copper from the cytoplasm to the periplasm...
  84. Kaji I, Akiba Y, Kato I, Maruta K, Kuwahara A, Kaunitz J. Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways. J Pharmacol Exp Ther. 2017;361:151-161 pubmed publisher
    b>Xenin-25, a neurotensin (NT)-related anorexigenic gut hormone generated mostly in the duodenal mucosa, is believed to increase the rate of duodenal ion secretion, because xenin-induced diarrhea is not present after Roux-en-Y gastric ..
  85. Fiedler K, Veit M, Stamnes M, Rothman J. Bimodal interaction of coatomer with the p24 family of putative cargo receptors. Science. 1996;273:1396-9 pubmed
    ..The either-or bimodal binding of coatomer to p24 tails suggests models for how coatomer can potentially package retrograde-directed and anterograde-directed cargo into distinct COPI-coated vesicles...
  86. Hansen K, Ronnstrand L, Rorsman C, Hellman U, Heldin C. Association of coatomer proteins with the beta-receptor for platelet-derived growth factor. Biochem Biophys Res Commun. 1997;235:455-60 pubmed
    ..The possible functional importance of the interaction between the PDGF beta-receptor and alpha- and beta'-COP, is discussed. ..
  87. Arslan N, Sayin O, Tokgöz Y. Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents. J Endocrinol Invest. 2014;37:1091-7 pubmed publisher
    b>Xenin is a peptide of the neurotensin/xenopsin/xenin family secreted from gastric cells and other tissues...
  88. Sánchez Sutil M, Marcos Torres F, Pérez J, Ruiz González M, García Bravo E, Martínez Cayuela M, et al. Dissection of the sensor domain of the copper-responsive histidine kinase CorS from Myxococcus xanthus. Environ Microbiol Rep. 2016;8:363-70 pubmed publisher
    ..of this metal it upregulates, among others, the genes encoding the multicopper oxidase CuoA and the P1B -ATPase CopA. Dissection of the periplasmic sensor domain of the histidine kinase CorS by the analysis of a series of in-frame ..
  89. Meydan S, Klepacki D, Karthikeyan S, Margus T, Thomas P, Jones J, et al. Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene. Mol Cell. 2017;65:207-219 pubmed publisher
    ..Although the copper ion transporter CopA has been known in Escherichia coli, no gene for its chaperone had been identified...
  90. Quek H, Chow V. Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex. DNA Cell Biol. 1997;16:275-80 pubmed
    ..Taken together with the cDNA data, the results of this immunological analysis of the putative HEP-COP protein support the suggestion that the latter is the human homolog of alpha-COP. ..
  91. Kano F, Yamauchi S, Yoshida Y, Watanabe Takahashi M, Nishikawa K, Nakamura N, et al. Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER. J Cell Sci. 2009;122:2218-27 pubmed publisher
    ..These results suggested that Yip1A has a role in COPI-independent retrograde transport from the Golgi to the ER and regulates the membrane recruitment of Rab6. ..
  92. Chow V, Quek H. HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. Gene. 1996;169:223-7 pubmed
    ..Considering the close similarities between HEP-COP and yeast alpha-COP, and the ubiquitous expression of HEP-COP implying an essential cellular role, it is likely that HEP-COP is the human homologue of alpha-COP. ..