COP9

Summary

Gene Symbol: COP9
Description: COP9 signalosome subunit 8
Alias: COP9, CSN8, SGN8, COP9 signalosome complex subunit 8, COP9 constitutive photomorphogenic homolog subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8, hCOP9, signalosome subunit 8
Species: human
Products:     COP9

Top Publications

  1. Yang X, Menon S, Lykke Andersen K, Tsuge T, Di Xiao -, Wang X, et al. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. Curr Biol. 2002;12:667-72 pubmed
    The COP9 signalosome (CSN) is a conserved protein complex with homologies to the lid subcomplex of the 26S proteasome. It promotes cleavage of the Nedd8 conjugate (deneddylation) from the cullin component of SCF ubiquitin ligases...
  2. Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech Otschir D, et al. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 2003;22:1302-12 pubmed
    The COP9 signalosome (CSN) purified from human erythrocytes possesses kinase activity that phosphoryl ates proteins such as c-Jun and p53 with consequence for their ubiquitin (Ub)-dependent degradation...
  3. Schweitzer K, Bozko P, Dubiel W, Naumann M. CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. EMBO J. 2007;26:1532-41 pubmed
    The COP9 signalosome (CSN) is a conserved protein complex that regulates assembly and activity of cullin-RING ubiquitin ligases (CRLs)...
  4. Huang X, Hetfeld B, Seifert U, Kahne T, Kloetzel P, Naumann M, et al. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005;272:3909-17 pubmed
    The COP9 signalosome (CSN) occurs in all eukaryotic cells. It is a regulatory particle of the ubiquitin (Ub)/26S proteasome system...
  5. Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
    The COP9 signalosome (CSN) is an eight-subunit protein complex that is found in all eukaryotes. Accumulating evidence indicates its diverse biological functions that are often linked to ubiquitin-mediated proteolysis...
  6. Chamovitz D, Wei N, Osterlund M, von Arnim A, Staub J, Matsui M, et al. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell. 1996;86:115-21 pubmed
    Arabidopsis COP9 is a component of a large protein complex that is essential for the light control of a developmental switch and whose conformation or size is modulated by light...
  7. Lyapina S, Cope G, Serino G, Tsuge T, Zhou C, Wolf D, et al. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science. 2001;292:1382-5 pubmed
    ..The COP9 signalosome (CSN), a suppressor of plant photomorphogenesis, associated with multiple cullins and promoted cleavage ..
  8. Min K, Kwon M, Park H, Park Y, Yoon S, Yoon J. CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun. 2005;334:867-74 pubmed
    ..We show here that CAND1 and COP9 signalosome (CSN), the major deneddylase of cullins, bind to unneddylated CUL1 in a mutually exclusive way...
  9. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell. 2003;113:357-67 pubmed
    ..Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN), a known regulator of cullin-based ubiquitin ligases...

More Information

Publications133 found, 100 shown here

  1. Lingaraju G, Bunker R, Cavadini S, Hess D, Hassiepen U, Renatus M, et al. Crystal structure of the human COP9 signalosome. Nature. 2014;512:161-5 pubmed publisher
    ..Cullin-RING E3 ubiquitin ligases (CRLs) are regulated by the eight-subunit COP9 signalosome (CSN). CSN inactivates CRLs by removing their covalently attached activator, NEDD8...
  2. Huang X, Langelotz C, Hetfeld Pechoc B, Schwenk W, Dubiel W. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. J Mol Biol. 2009;391:691-702 pubmed publisher
    ..The COP9 signalosome (CSN) regulates the UPS by controlling cullin-RING Ub ligases (CRLs)...
  3. Emberley E, Mosadeghi R, Deshaies R. Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem. 2012;287:29679-89 pubmed publisher
    b>COP9 signalosome (CSN) mediates deconjugation of the ubiquitin-like protein Nedd8 from the cullin subunits of SCF and other cullin-RING ubiquitin ligases (CRLs). This process is essential to maintain the proper activity of CRLs in cells...
  4. Peth A, Boettcher J, Dubiel W. Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability. J Mol Biol. 2007;368:550-63 pubmed
    The COP9 signalosome (CSN) is a regulatory particle of the ubiquitin (Ub) proteasome system (UPS) consisting of eight subunits (CSN1-CSN8)...
  5. Tanaka T, Nakatani T, Kamitani T. Negative regulation of NEDD8 conjugation pathway by novel molecules and agents for anticancer therapy. Curr Pharm Des. 2013;19:4131-9 pubmed
    ..g. COP9 signalosome, CAND1, inactive mutant of Ubc12 and NUB1/NUB1L) and clarifies possible strategies for targeting the ..
  6. Taye B, Yeo D, Lee R, Tan B, Sugrue R, Maurer Stroh S. Inter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strains. Int J Mol Sci. 2017;18: pubmed publisher
    ..g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2))...
  7. Sinha S, Dwivedi T, Yengkhom R, Bheemsetty V, Abe T, Kiyonari H, et al. Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Blood. 2019;: pubmed publisher
    ..and biochemical analyses revealed increased polyubiquitinated protein levels, Akt/STAT5 activation and CSN5 (COP9 signalosome subunit 5)-mediated p53 ubiquitination and degradation in KO HSPCs...
  8. Kolobynina K, Solovyova V, Levay K, Rizvanov A, Slepak V. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation. J Cell Sci. 2016;129:3533-3540 pubmed
    ..interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3)...
  9. Dong L, Zhang X, Xiang W, Ni J, Zhou W, Li H. Post-transcription mediated Snail stabilization is involved in radiation exposure induced invasion and migration of hepatocarcinoma cells. Biomed Pharmacother. 2018;103:767-772 pubmed publisher
    ..Radiation increased the expression of COP9 signalosome 2 (CSN2), which has been reported to block the ubiquitination and degradation of Snail...
  10. Xu W, Liu H, Liu Z, Wang H, Zhang F, Wang H, et al. Histone deacetylase inhibitors upregulate Snail via Smad2/3 phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells. Cancer Lett. 2018;420:1-13 pubmed publisher
    ..Secondly, we showed that HDACIs regulated the stabilization of Snail via upregulating the expression of COP9 signalosome 2 (CSN2), which combined with Snail and exposed its acetylation site, then promoted acetylation of ..
  11. Li Y, Chu Z, Luo J, Zhou Y, Cai Y, Lu Y, et al. The C2H2 zinc finger-protein SlZF3 regulates AsA synthesis and salt tolerance by interacting with CSN5B. Plant Biotechnol J. 2017;: pubmed publisher
    ..Protein-protein interaction assays demonstrated that SlZF3 directly binds CSN5B, a key component of the COP9 signalosome...
  12. Lim S, Li C, Xia W, Cha J, Chan L, Wu Y, et al. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016;30:925-939 pubmed publisher
    ..We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-?B p65, is required for TNF-?-mediated PD-L1 stabilization in cancer cells...
  13. Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere. Molecules. 2019;24: pubmed publisher
    ..of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8)...
  14. Zhao S, Tang H, Yan D, Fan J, Sun H, Wen Y, et al. DDA1 promotes stage IIB-IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling. Oncotarget. 2016;7:19794-812 pubmed publisher
    ..We also demonstrated that DDA1-mediated tumor progression is associated with the activation of the NFκB/COP9 signalosome 2(CSN2)/glycogen synthase kinase3β (GSK3β) pathway...
  15. de Groen F, Timmer L, Menezes R, Diosdado B, Hooijberg E, Meijer G, et al. Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression. PLoS ONE. 2015;10:e0132495 pubmed publisher
    ..levels with mRNA expression data of predicted target genes identified mitochondrial uncoupling protein 2 (UCP2) and COP9 signalosome subunit 2 (COPS2) as candidates with significantly decreased expression in CRCs with 13q gain...
  16. Bayne E, Bijos D, White S, de Lima Alves F, Rappsilber J, Allshire R. A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast. Genome Biol. 2014;15:481 pubmed
    ..proteins,which are required for proper processing of centromeric transcripts by the RNAi pathway, and COP9 signalosome components Csn1 and Csn2, whose role in heterochromatin assembly can be explained at least in part by a ..
  17. Huang R, Gorman K, Vinci C, Dobrovetsky E, Gräslund S, Kay B. Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step. Int J Mol Sci. 2015;16:23587-603 pubmed publisher
    ..nanomolar fibronectin type III (FN3) monobodies to five human proteins: ubiquitin-conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen-activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A ..
  18. Schenstrøm S, Rebula C, Tatham M, Hendus Altenburger R, Jourdain I, Hay R, et al. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Cell Rep. 2018;25:862-870 pubmed publisher
    ..Here in Schizosaccharomyces pombe, we expand its interactome further to include eIF3, the COP9 signalosome, and the mitotic septins...
  19. Gaspar L, Howald C, Popadin K, Maier B, Mauvoisin D, Moriggi E, et al. The genomic landscape of human cellular circadian variation points to a novel role for the signalosome. elife. 2017;6: pubmed publisher
    ..The two most significant alleles regulated expression of COPS7B, a subunit of the COP9 signalosome...
  20. Zhou W, Wang Q, Xu Y, Jiang J, Guo J, Yu H, et al. RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma. Oncotarget. 2017;8:40373-40388 pubmed publisher
    ..NF-κB is activated by RMP, which directly promotes the expression of COP9 signalosome 2 (CSN2) to repress the degradation of Snail...
  21. Samsa W, Zhou X, Zhou G. Signaling pathways regulating cartilage growth plate formation and activity. Semin Cell Dev Biol. 2017;62:3-15 pubmed publisher
    ..Furthermore, we discuss newly uncovered pathways involved in growth plate formation, including mTOR, the circadian clock, and the COP9 signalosome.
  22. Carreira Rosario A, Buszczak M. A competitive cell fate switch. Dev Cell. 2014;31:261-2 pubmed publisher
    ..Pan et al. (2014) now show that competitive protein-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions within the Drosophila ovarian germline stem cell lineage.
  23. Cornelius R, Si J, Cuevas C, Nelson J, Gratreak B, Pardi R, et al. Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway. J Am Soc Nephrol. 2018;29:2627-2640 pubmed publisher
    ..CUL3 mutant (CUL3Δ9) does not bind normally to the COP9 signalosome (CSN), a deneddylase involved in regulating cullin-RING ligases...
  24. Scherer P, Ding Y, Liu Z, Xu J, Mao H, Barrow J, et al. Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc Natl Acad Sci U S A. 2016;113:3503-8 pubmed publisher
    The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains ..
  25. Lee E, Oh W, Song H, Kim W. Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53. BMB Rep. 2017;50:373-378 pubmed
    ..Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases...
  26. Zhu Y, Li F, Shi W, Zhai C, Wang J, Yan X, et al. COP9 signalosome subunit 6 mediates PDGF -induced pulmonary arterial smooth muscle cells proliferation. Exp Cell Res. 2018;371:379-388 pubmed publisher
    Up-regulation of mammalian COP9 signalosome subunit 6 (CSN6) and consequent reduction of SCF ubiquitin ligase substrate receptor ?-transduction repeat-containing protein (?-TrCP) have been shown to be associated with cancer cells ..
  27. Hasima N, Aggarwal B. Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. Curr Med Chem. 2014;21:1583-94 pubmed
    ..Curcumin is also a potent inhibitor of COP9 signalosome and associated kinases, casein kinase 2 and protein kinase D, all linked to the ubiquitin-proteasomal ..
  28. Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
    ..Together, our results suggest that doxycycline may represent a promising therapeutic agent for DLBCL and other non-Hodgkin lymphomas subtypes. ..
  29. Bornstein G, Grossman C. COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex. Cell Div. 2015;10:5 pubmed publisher
    ..extent are regulated by 2 opposing enzymatic processes: neddylation by an enzymatic cascade, and deneddylation by COP9-Signalosome (CSN) complex protein...
  30. Golan A, Wei N, Pick E. Immunodepletion and Immunopurification as Approaches for CSN Research. Methods Mol Biol. 2016;1449:103-16 pubmed publisher
    The COP9 signalosome (CSN) is an evolutionary conserved complex that is found in all eukaryotes, and implicated in regulating the activity of Cullin-RING ubiquitin Ligases (CRLs)...
  31. Wei S, Li X, Gruber M, Feyissa B, Amyot L, Hannoufa A. COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis. BMC Plant Biol. 2018;18:134 pubmed publisher
    ..CSN5a, encoding COP9 signalosome subunit 5a, has also been implicated in trichome and anthocyanin production; however, the regulatory ..
  32. Zhang Q, Jin R, Zhang X, Sheng J, Yu F, Tan R, et al. The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment. Oncotarget. 2016;7:69688-69702 pubmed publisher
    Curcumin has shown promise as a safe and specific anticancer agent. The COP9 signalosome (CSN) component CSN5, a known specific target for curcumin, can control p53 stability by increasing its degradation through ubiquitin system...
  33. Zhu Y, Qiu Z, Zhang X, Qian F, Wang B, Wang L, et al. Jab1 promotes glioma cell proliferation by regulating Siah1/?-catenin pathway. J Neurooncol. 2017;131:31-39 pubmed publisher
    Jab1 (Jun activation domain-binding protein 1), also known as CSN5 (COP9 signalosome subunit 5), is frequently overexpressed in several cancer types...
  34. Birol M, Echalier A. Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins. Curr Protein Pept Sci. 2014;15:504-17 pubmed
    ..in association with other molecules in large protein complexes, where examples comprise; the 26S proteasome and the COP9 (Constitutive photomorphogenesis 9) signalosome complexes, including the MPN subunits, POH1 and Mov34, CSN5 and ..
  35. Liu S, Wan L, Gao L, Kong Y, Li X, Zhang Z. [Expression of CSN Complex in ATRA-induced APL Cell Differentiation and Its Clinical Significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1277-81 pubmed publisher
    To investigate the expression of CSN complex (COP9 signal some subunits) in the patients with acute promyelocytic leukemia (APL) and its significance in the ATRA-induced APL differentiation...
  36. Niikura Y, Kitagawa R, Kitagawa K. CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions. Cell Rep. 2016;15:61-76 pubmed publisher
    ..Consistent with this model is our finding that overexpression of a monoubiquitin-fused CENP-A mutant induces neocentromeres at noncentromeric regions of chromosomes. ..
  37. Zhang F, Yan T, Guo W, Sun K, Wang S, Bao X, et al. Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy. J Exp Clin Cancer Res. 2018;37:135 pubmed publisher
    Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis...
  38. Birol M, Enchev R, Padilla A, Stengel F, Aebersold R, Betzi S, et al. Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. PLoS ONE. 2014;9:e105688 pubmed publisher
    The Cop9 signalosome complex (CSN) regulates the functional cycle of the major E3 ubiquitin ligase family, the cullin RING E3 ubiquitin ligases (CRLs)...
  39. Mao L, Le S, Jin X, Liu G, Chen J, Hu J. CSN5 promotes the invasion and metastasis of pancreatic cancer by stabilization of FOXM1. Exp Cell Res. 2018;: pubmed publisher
    b>COP9 signalosome subunit 5 (CSN5) has been involved in the progression of diverse human cancers. MMP2 plays an important role in the metastasis of cancer cells...
  40. Miller R, Qadota H, Stark T, Mercer K, Wortham T, Anyanful A, et al. CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Mol Biol Cell. 2009;20:3608-16 pubmed publisher
    ..We found that CSN-5, a component of the COP9 signalosome complex, binds to UNC-98 and -96 using the yeast two-hybrid method...
  41. Pan L, Wang S, Lu T, Weng C, Song X, Park J, et al. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014;514:233-6 pubmed publisher
    ..melanogaster ovarian GSCs to demonstrate that the differentiation factor Bam controls the functional switch of the COP9 complex from self-renewal to differentiation via protein competition...
  42. Brockway H, Balukoff N, Dean M, Alleva B, Smolikove S. The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans. PLoS Genet. 2014;10:e1004757 pubmed publisher
    ..The assembly of the SC is likely to be regulated by post-translational modifications. The CSN/COP9 signalosome has been shown to act in many pathways, mainly via the ubiquitin degradation/proteasome pathway...
  43. Chen J, Shin J, Zhao R, Phan L, Wang H, Xue Y, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384 pubmed publisher
    Cullin-RING ubiquitin ligases (CRLs) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitination/degradation is unclear...
  44. Hu Y, Wu Y, Li Q, Zhang W, Jin C. Solution structure of yeast Rpn9: insights into proteasome lid assembly. J Biol Chem. 2015;290:6878-89 pubmed publisher
    ..of the RP contains an Rpn8-Rpn11 heterodimer surrounded by a horseshoe-shaped scaffold formed by six proteasome-COP9/CSN-initiation factor (PCI)-containing subunits...
  45. Ma X, Xu M, Jiang T. Crystal structure of the human CSN6 MPN domain. Biochem Biophys Res Commun. 2014;453:25-30 pubmed publisher
    The mammalian COP9 signalosome is an eight-subunit (CSN1-CSN8) complex that plays essential roles in multiple cellular and physiological processes...
  46. Choi H, Guma S, Fang L, Phan L, Ivan C, Baggerly K, et al. Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis. Cell Cycle. 2015;14:2265-73 pubmed publisher
    The COP9 signalosome subunit 6 (CSN6), which is involved in ubiquitin-mediated protein degradation, is overexpressed in many types of cancer...
  47. Huang Y, Lu Y, Wu J, Chien C, Pi H. The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence. PLoS Genet. 2014;10:e1004760 pubmed publisher
    ..We found that the COP9 signalosome (CSN) suppresses the neural competence of non-innervated bristles at the PWM...
  48. Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández Ávila M, et al. The COP9 signalosome is vital for timely repair of DNA double-strand breaks. Nucleic Acids Res. 2015;43:4517-30 pubmed publisher
    ..The chief mobilizer of the DSB response is the ATM protein kinase. We discovered that the COP9 signalosome (CSN) is a crucial player in the DSB response and an ATM target...
  49. Fang L, Lu W, Choi H, Yeung S, Tung J, Hsiao C, et al. ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. Cancer Cell. 2015;28:183-97 pubmed publisher
    ..We found that CSN6, a subunit of COP9 signalosome, is overexpressed in CRC samples and that CSN6 overexpression is correlated with poor patient survival...
  50. Dubiel D, Ordemann J, Pratschke J, Dubiel W, Naumann M. CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. Int J Biochem Cell Biol. 2015;66:95-100 pubmed publisher
    ..of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1...
  51. Schweitzer K, Pralow A, Naumann M. p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα. J Cell Mol Med. 2016;20:58-70 pubmed publisher
    ..removal of the CRL-activating modification of their cullin subunit with the ubiquitin (Ub)-like modifier NEDD8, the COP9 signalosome (CSN) opposes CRL Ub-ligase activity...
  52. Miller C, Harper A, Trick M, Werner P, Waldron K, Bancroft I. Elucidation of the genetic basis of variation for stem strength characteristics in bread wheat by Associative Transcriptomics. BMC Genomics. 2016;17:500 pubmed publisher
    ..revealed candidates for the causative genes underlying the trait variation, implicating xylan acetylation and the COP9 signalosome as contributing to stem strength and auxin in the control of the observed variation for plant height...
  53. Ba M, Surina J, Singer C, Valencik M. Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway. BMC Pharmacol Toxicol. 2017;18:47 pubmed publisher
    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex...
  54. Wicker C, Izumi T. Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components. BMC Genomics. 2016;17:983 pubmed
    The COP9 signalosome, composed of eight subunits, is implicated in cancer genetics with its deneddylase activity to modulate cellular concentration of oncogenic proteins such as IkB and TGFβ...
  55. MacPherson M, Molina P, Souchelnytskyi S, Wernstedt C, Martin Perez J, Portillo F, et al. Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell. 2010;21:244-53 pubmed publisher
    ..mechanisms independent of GSK3beta have also been reported, including interaction with LOXL2 or regulation of the COP9 signalosome by inflammatory signals...
  56. Mosadeghi R, Reichermeier K, Winkler M, Schreiber A, Reitsma J, Zhang Y, et al. Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. elife. 2016;5: pubmed publisher
    The COP9-Signalosome (CSN) regulates cullin-RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated...
  57. Lu R, Hu X, Zhou J, Sun J, Zhu A, Xu X, et al. COPS5 amplification and overexpression confers tamoxifen-resistance in ER?-positive breast cancer by degradation of NCoR. Nat Commun. 2016;7:12044 pubmed publisher
    ..Amplification and overexpression of COPS5, a catalytic subunit of the COP9 complex, is present in about 9% of the ER?+ primary breast cancer and more frequently (86...
  58. Korczeniewska J, Barnes B. Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability. Mol Cell Biol. 2018;38: pubmed publisher
    ..Here we report that the COP9 signalosome (CSN), a general modulator of diverse cellular and developmental processes, associates constitutively ..
  59. Zheng Y, Wang X, Zhang X, Li W, Liu G, Wang S, et al. COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici. Sci China Life Sci. 2017;60:656-664 pubmed publisher
    The COP9 signalosome (CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development...
  60. Chamovitz D, Deng X. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. Cell. 1995;82:353-4 pubmed
  61. Enchev R, Scott D, da Fonseca P, Schreiber A, Monda J, Schulman B, et al. Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep. 2012;2:616-27 pubmed publisher
    ..E3 ligases are activated by ligation to the ubiquitin-like protein Nedd8, which is reversed by the deneddylating Cop9 signalosome (CSN). However, CSN also promotes SCF substrate turnover through unknown mechanisms...
  62. Shin J, Phan L, Chen J, Lu Z, Lee M. CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. 2015;14:3079-87 pubmed publisher
    ..Understanding the c-Jun regulation is important to develop treatment strategy for cancer. The COP9 signalosome subunit 6 (CSN6) plays a critical role in ubiquitin-mediated protein degradation...
  63. Sang M, Du W, Zhang R, Zheng J, Pei D. Suppression of CSN5 promotes the apoptosis of gastric cancer cells through regulating p53-related apoptotic pathways. Bioorg Med Chem Lett. 2015;25:2897-901 pubmed publisher
    As one of the COP9 signalosome complex, CSN5 (also known as Jab1) has been confirmed overexpression in many human cancers and affected multiple pathways associating with cell proliferation and apoptosis...
  64. Jumpertz S, Hennes T, Asare Y, Schütz A, Bernhagen J. CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. Cell Signal. 2017;34:38-46 pubmed publisher
    The COP9 signalosome (CSN) is a multi-protein complex that is highly conserved in eukaryotes. Due to its regulatory impact on processes such as cell cycle, DNA damage response and apoptosis, the CSN is essential for mammalian cells...
  65. Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, et al. The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochem Biophys Res Commun. 2016;479:708-714 pubmed publisher
    ..First, we found that OXGR1 forms a molecular complex with the COP9 signalosome complex subunit 5 (CSN5)...
  66. Britten R, Jewell J, Davis L, Miller V, Hadley M, Semmes O, et al. Changes in the Hippocampal Proteome Associated with Spatial Memory Impairment after Exposure to Low (20 cGy) Doses of 1 GeV/n 56Fe Radiation. Radiat Res. 2017;187:287-297 pubmed publisher
    ..Thirty percent (37/107) of these "radiation biomarkers" formed a functional interactome of the proteasome and the COP9 signalosome...
  67. Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
    The COP9 signalosome (CSN) is a central component of the activation and remodelling cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin-proteasome system in humans...
  68. Hong Y, Huang X, An L, Ye H, Ma K, Zhang F, et al. Overexpression of COPS3 promotes clear cell renal cell carcinoma progression via regulation of Phospho-AKT(Thr308), Cyclin D1 and Caspase-3. Exp Cell Res. 2018;365:163-170 pubmed publisher
    The third subunit of the COP9 signalosome (COPS3) is associated with cell proliferation and tumorigenesis process in cancer...
  69. Kim K, Yoon J, Yim J, Kim H. Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster. Insect Sci. 2017;24:27-34 pubmed publisher
    NEDD8 conjugation of Cullin has an important role in ubiquitin-mediated protein degradation. The COP9 signalosome, of which CSN5 is the major catalytic subunit, is a major Cullin deneddylase...
  70. Li S, Wang J, Yu Y, Wang F, Dong J, Huang R. D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis. Plant Mol Biol. 2016;92:473-482 pubmed
    ..ascorbic acid (AsA) biosynthesis enzyme, could be degraded through interaction with the photomorphogenic factor COP9 signalosome subunit 5B (CSN5B) in the darkness, demonstrating the posttranscriptional regulation of light signal in ..
  71. Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, et al. Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis. Mol Med Rep. 2016;14:4559-4566 pubmed publisher
    Constitutive photomorphogenesis 9 signalosome (CSN) consists of a total of eight subunits (CSN1-CSN8) in mammalian cells...
  72. Chou C, Chang Y, Korinek M, Chen Y, Yang Y, Leu S, et al. The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases. Int J Mol Sci. 2017;18: pubmed publisher
    ..USP15 cooperates with COP9 signalosome complex (CSN) to maintain the stability of cullin-ring ligase (CRL) adaptor proteins by removing the ..
  73. Pick E, Golan A, Zimbler J, Guo L, Sharaby Y, Tsuge T, et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS ONE. 2012;7:e43980 pubmed publisher
    The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through modulating the cullin ubiquitin E3 ligases in the ubiquitin-proteasome pathway...
  74. Lu T, Wang S, Gao Y, Mao Y, Yang Z, Liu L, et al. COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development. 2015;142:4242-52 pubmed publisher
    ..Here, this study reveals a new role of COP9 in the differentiation niche to modulate autocrine Hedgehog (Hh) signaling, thereby promoting GSC lineage ..
  75. Hou J, Deng Q, Zhou J, Zou J, Zhang Y, Tan P, et al. CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR. Oncogene. 2017;36:1134-1144 pubmed publisher
    CSN6, a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), has received attention as a regulator of the degradation of cancer-related proteins such as p53, c-myc and c-Jun, through the ubiquitin-proteasome ..
  76. Păcurar D, Pacurar M, Lakehal A, Pacurar A, Ranjan A, Bellini C. The Arabidopsis Cop9 signalosome subunit 4 (CNS4) is involved in adventitious root formation. Sci Rep. 2017;7:628 pubmed publisher
    The COP9 signalosome (CSN) is an evolutionary conserved multiprotein complex that regulates many aspects of plant development by controlling the activity of CULLIN-RING E3 ubiquitin ligases (CRLs)...
  77. Franciosini A, Moubayidin L, Du K, Matari N, Boccaccini A, Butera S, et al. The COP9 SIGNALOSOME Is Required for Postembryonic Meristem Maintenance in Arabidopsis thaliana. Mol Plant. 2015;8:1623-34 pubmed publisher
    ..The constitutively photomorphogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs activity by reverting their neddylation status, but its ..
  78. Dubois E, Gerber S, KISSELEV A, Harel Bellan A, Groisman R. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Oncol Rep. 2016;35:3101-5 pubmed publisher
    The COP9/signalosome (CSN) multi-protein complex regulates the activity of cullin-RING ubiquitin ligases (CRLs), including the DDB2 and CSA CRL4 ligases (CRL4DDB2 and CRL4CSA), which are involved in the repair of UV-induced DNA damages...
  79. Tan S, Liu F, Pan X, Zang Y, Jin F, Zu W, et al. CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa. Sci Rep. 2016;6:25485 pubmed publisher
    The COP9 signalosome (CSN) plays an important role in proteasome-mediated degradation by regulating CUL1 rubylation of the SCF ligase and is involved in many crucial biological processes...
  80. Ma Y, Yan M, Huang H, Zhang L, Wang Q, Zhao Y, et al. Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non-Hodgkin lymphoma. Mol Clin Oncol. 2016;5:357-364 pubmed
    ..The incidence of NHL is increasing at an annual rate of 3%. The human Jun activation domain-binding protein 1/COP9 signalosome subunit 5 (Jab1/CSN5) is a negative regulator of the cell cycle inhibitor p27Kip1 and ..
  81. Chung D, Dellaire G. The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair. Biomolecules. 2015;5:2388-416 pubmed publisher
    ..Proteins in the neddylation pathway have also been linked to regulating DDR. Of interest is the COP9 signalosome (CSN), a multi-subunit metalloprotease present in eukaryotes that removes NEDD8 from cullins and ..
  82. Fan Y, Tao X, Pan W, Fang W, Huang Y, Jia M. CSN1201, a subunit of the COP9 signalosome, regulates the virulence in Cryptococcus neoformans infection. Fungal Genet Biol. 2016;: pubmed publisher
    The COP9 signalosome (CSN) is a multisubunit protein complex, and it now has been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Cryptococcus neoformans (C...
  83. Schwechheimer C, Deng X. COP9 signalosome revisited: a novel mediator of protein degradation. Trends Cell Biol. 2001;11:420-6 pubmed
    The COP9 signalosome is an evolutionarily conserved multiprotein complex that was first identified as an essential complex that represses light-regulated development in Arabidopsis...
  84. Azuma Y, Takada M, Maeda M, Kioka N, Ueda K. The COP9 signalosome controls ubiquitinylation of ABCA1. Biochem Biophys Res Commun. 2009;382:145-8 pubmed publisher
    ..In this study, we analyzed the putative interaction between ABCA1 and COP9 signalosome (CSN), a key molecule in controlling protein ubiquitination and deubiquitination...
  85. Kapelari B, Bech Otschir D, Hegerl R, Schade R, Dumdey R, Dubiel W. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J Mol Biol. 2000;300:1169-78 pubmed
    The COP9 signalosome is involved in signal transduction, whereas the 26 S proteasome lid is a regulatory subcomplex of the 26 S proteasome responsible for degradation of ubiquitinated proteins...
  86. Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech Otschir D, et al. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. J Biol Chem. 2000;275:39081-9 pubmed
    ..Trip15 was recently identified as a component of the COP9/signalosome (CSN) complex composed of eight evolutionary conserved subunits and thus termed CSN2...
  87. Yi C, Wang H, Wei N, Deng X. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002;3:30 pubmed
    ..Therefore, in addition to its well-characterized role in ubiquitination, the RING finger domain may also play a structural role in nuclear import. ..
  88. Wolf D, Zhou C, Wee S. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?. Nat Cell Biol. 2003;5:1029-33 pubmed
    The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis...
  89. Niikura Y, Kitagawa R, Ogi H, Abdulle R, Pagala V, Kitagawa K. CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere. Dev Cell. 2015;32:589-603 pubmed publisher
    ..Thus, CENP-A K124R ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex, is essential for CENP-A deposition at the centromere. ..
  90. Naumann M, Bech Otschir D, Huang X, Ferrell K, Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999;274:35297-300 pubmed
    ..we demonstrate a JNK-independent activation of c-Jun in vivo directed by the constitutive photomorphogenesis (COP9) signalosome...
  91. Huang X, Ordemann J, Muller J, Dubiel W. The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis. Biol Open. 2012;1:705-10 pubmed publisher
    ..Here we investigate the impact of the COP9 signalosome (CSN), a regulator of cullin-RING ubiquitin ligases (CRLs), and of C/EBP homologous protein (CHOP) on ..
  92. Galgano D, Onnis A, Pappalardo E, Galvagni F, Acuto O, Baldari C. The T cell IFT20 interactome reveals new players in immune synapse assembly. J Cell Sci. 2017;130:1110-1121 pubmed publisher
    ..including IFT54 (also known as TRAF3IP1), GMAP-210 (also known as TRIP11), Arp2/3 complex subunit-3 (ARPC3), COP9 signalosome subunit-1 (CSN1, also known as GPS1) and ERGIC-53 (also known as LMAN1)...