COP1

Summary

Gene Symbol: COP1
Description: COP1, E3 ubiquitin ligase
Alias: RFWD2, RNF200, E3 ubiquitin-protein ligase COP1, E3 ubiquitin-protein ligase RFWD2, RING finger protein 200, RING-type E3 ubiquitin transferase RFWD2, constitutive photomorphogenesis protein 1 homolog, constitutive photomorphogenic protein 1, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Species: human
Products:     COP1

Top Publications

  1. Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, et al. Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity. J Biol Chem. 2003;278:19682-90 pubmed
    ..Here we report the cloning and characterization of the human orthologue of atCOP1. Human COP1 (huCOP1) distributes both to the cytoplasm and the nucleus of cells and shows a striking degree of sequence ..
  2. Kato S, Ding J, Pisck E, Jhala U, Du K. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008;283:35464-73 pubmed publisher
    b>COP1 is a Ring-Finger E3 ubiquitin ligase that is involved in plant development, mammalian cell survival, growth, and metabolism. Here we report that COP1, whose expression is enhanced by insulin, regulates FoxO1 protein stability...
  3. Vitari A, Leong K, Newton K, Yee C, O Rourke K, Liu J, et al. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011;474:403-6 pubmed publisher
    ..Here we identify the ubiquitin ligase COP1 (also known as RFWD2) as a tumour suppressor that negatively regulates ETV1, ETV4 and ETV5...
  4. Dornan D, Bheddah S, Newton K, Ince W, Frantz G, Dowd P, et al. COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas. Cancer Res. 2004;64:7226-30 pubmed
    ..We recently identified COP1 as a novel and critical negative regulator of p53...
  5. Wertz I, O Rourke K, Zhang Z, Dornan D, Arnott D, Deshaies R, et al. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science. 2004;303:1371-4 pubmed
    ..Ablation of any subunit by RNA interference stabilized c-Jun and increased c-Jun-activated transcription. These findings characterize a c-Jun ubiquitin ligase and define a specific function for hDET1 in mammalian cells. ..
  6. Yi C, Li S, Wang J, Wei N, Deng X. Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells. Int J Biochem Cell Biol. 2006;38:1076-83 pubmed
    Constitutive photomorphogenic 1 (COP1), a protein composed of a RING finger, a coiled-coil domain and seven WD40 repeats, functions as an E3 ubiquitin ligase that targets key transcription factors for ubiquitination and degradation in ..
  7. Wang L, He G, Zhang P, Wang X, Jiang M, Yu L. Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53. Mol Biol Rep. 2011;38:229-36 pubmed publisher
    MDM2, Pirh2 and COP1 are important E3 ubiquitin ligases, which directly interact with p53 and target p53 for proteasome-mediated degradation. MDMX, the MDM2 homologous protein, inhibits p53-mediated transcription activity...
  8. Su C, Zhao R, Zhang F, Qu C, Chen B, Feng Y, et al. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res. 2011;71:884-94 pubmed publisher
    Constitutive photomorphogenic 1 (COP1) is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that remain obscure...
  9. Dornan D, Wertz I, Shimizu H, Arnott D, Frantz G, Dowd P, et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004;429:86-92 pubmed
    b>COP1 (constitutively photomorphogenic 1) is a RING-finger-containing protein that functions to repress plant photomorphogenesis, the light-mediated programme of plant development...

More Information

Publications104 found, 100 shown here

  1. Savio M, Rotondo G, Maglie S, Rossetti G, Bender J, Pardi R. COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of full-length COP1. Oncogene. 2008;27:2401-11 pubmed
    b>COP1 is an evolutionarily conserved RING-finger ubiquitin ligase acting within a Cullin-RING ligase (CRL) complex that promotes polyubiquitination of c-Jun and p53...
  2. Shao J, Teng Y, Padia R, Hong S, Noh H, Xie X, et al. COP1 and GSK3? cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis. Neoplasia. 2013;15:1075-85 pubmed
    ..Among the known c-Jun-targeting E3 ligases, we identified constitutive photomorphogenesis protein 1 (COP1) as an E3 ligase responsible for c-Jun degradation in less invasive breast cancer cells because depletion of COP1 ..
  3. Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O Rourke K, et al. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science. 2006;313:1122-6 pubmed
    ..effecter of this pathway, the tumor suppressor protein p53, is tightly regulated by controlled degradation through COP1 and other E3 ubiquitin ligases, such as MDM2 and Pirh2; however, the signal transduction pathway that regulates the ..
  4. Dentin R, Liu Y, Koo S, Hedrick S, Vargas T, Heredia J, et al. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature. 2007;449:366-9 pubmed
    ..Phosphorylated TORC2 was degraded by the 26S proteasome during re-feeding through an association with COP1, a substrate receptor for an E3 ligase complex that promoted TORC2 ubiquitination at Lys 628...
  5. Li D, Ohshiro K, Reddy S, Pakala S, Lee M, Zhang Y, et al. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A. 2009;106:17493-8 pubmed publisher
    ..protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive photomorphogenesis protein 1 (COP1) for degradation via the ubiquitin-proteasome pathway...
  6. Li Y, Wang D, Zhao B, Wang W, Huang C, Chen Y, et al. High level of COP1 expression is associated with poor prognosis in primary gastric cancer. Int J Biol Sci. 2012;8:1168-77 pubmed publisher
    COP1 (constitutive photomorphogenic 1, also known as RFWD2) is a p53-targeting E3 ubiquitin ligase containing RING-finger, coiled-coil, and WD40-repeat domains...
  7. Wang H, Kang D, Deng X, Wei N. Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. Curr Biol. 1999;9:711-4 pubmed
    Identified in Arabidopsis as a repressor of light-regulated development, the COP1 (constitutively photomorphogenic 1) protein is characterized by a RING-finger motif and a WD40 repeat domain [1]...
  8. Baert J, Monte D, Verreman K, Degerny C, Coutte L, de Launoit Y. The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity. Oncogene. 2010;29:1810-20 pubmed publisher
    ..with the mammalian really interesting new gene (RING) E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1), which mediates ubiquitylation and subsequent proteasome degradation of the p53 and c-Jun transcription factors...
  9. Lee Y, Andersen J, Song H, Judge A, Seo D, Ishikawa T, et al. Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma. Cancer Res. 2010;70:8264-9 pubmed publisher
    ..The ubiquitination modulator COP1 regulates p53 activity by ubiquitination and it is frequently overexpressed in human HCC...
  10. Choi H, Gully C, Su C, Velazquez Torres G, Chou P, Tseng C, et al. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3?. Oncogene. 2011;30:4791-801 pubmed publisher
    ..In this study, we identify mammalian constitutive photomorphogenic 1 (COP1) as a novel E3 ubiquitin ligase for targeting 14-3-3? through proteasomal degradation...
  11. Taniguchi H, Busche T, Patschkowski T, Niehaus K, Pátek M, Kalinowski J, et al. Physiological roles of sigma factor SigD in Corynebacterium glutamicum. BMC Microbiol. 2017;17:158 pubmed publisher
    ..of genes related to corynomycolic acid synthesis (fadD2, pks), genes encoding corynomycolyl transferases (cop1, cmt1, cmt2, cmt3), L, D-transpeptidase (lppS), a subunit of the major cell wall channel (porH), and the envelope ..
  12. Mondal D, Mathur A, Chandra P. Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer. Biochimie. 2016;124:34-52 pubmed publisher
    ..The MEK1 binding domain of TRIB3 enables it to deactivate multiple MAP-kinases. In addition, the COP1 motif of TRIB3 assists ubiquitination and proteasomal degradation of numerous TRIB3 associated proteins...
  13. Liu L, Li Y, She G, Zhang X, Jordan B, Chen Q, et al. Metabolite profiling and transcriptomic analyses reveal an essential role of UVR8-mediated signal transduction pathway in regulating flavonoid biosynthesis in tea plants (Camellia sinensis) in response to shading. BMC Plant Biol. 2018;18:233 pubmed publisher
    ..suggested that a number of photoreceptors and potential genes involved in UV-B signal transductions (UVR8_L, HY5, COP1 and RUP1/2) showed decreasing expression patterns consistent with structural genes (F3'H, FLS, ANS, ANR, LAR, DFR ..
  14. Hayes S, Sharma A, Fraser D, Trevisan M, Cragg Barber C, Tavridou E, et al. UV-B Perceived by the UVR8 Photoreceptor Inhibits Plant Thermomorphogenesis. Curr Biol. 2017;27:120-127 pubmed publisher
    ..Suppression of thermomorphogenesis involves UVR8 and CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1)-mediated repression of PIF4 transcript accumulation, reducing PIF4 abundance...
  15. Elrouby N. Regulation of Plant Cellular and Organismal Development by SUMO. Adv Exp Med Biol. 2017;963:227-247 pubmed publisher
    ..The regulation of COP1 and PhyB functions by sumoylation provides very strong evidence that SUMO is heavily involved in the regulation of ..
  16. Greiner A, Kelterborn S, Evers H, Kreimer G, Sizova I, Hegemann P. Targeting of Photoreceptor Genes in Chlamydomonas reinhardtii via Zinc-Finger Nucleases and CRISPR/Cas9. Plant Cell. 2017;29:2498-2518 pubmed publisher
    ..Using this technique, we disrupted the photoreceptor genes COP1/2, COP3 (encoding channelrhodopsin 1 [ChR1]), COP4 (encoding ChR2), COP5, PHOT, ..
  17. Gao W, Tang H, Cheng Y, Chan C, Chan C, Jin D. Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1. Biochim Biophys Acta Gene Regul Mech. 2018;1861:211-223 pubmed publisher
    ..Finally, SIK1-induced ubiquitination of CRTC1 was mediated by RFWD2 ubiquitin ligase at a site not equivalent to K628 in CRTC2...
  18. Lee S, Huang K. Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia. BMC Med Genomics. 2016;9:68 pubmed publisher
    ..are 10 hypermethylated SDMGs, including GNA13, CAPNS1, GABPB2, GIT2, LEFTY1, NDUFA10, MIOS, MPHOSPH6, PRDM14 and RFWD2. The hypermethylation to differential expression network (HyDEN) were constructed to determine how the ..
  19. Xu D, Marino G, Klingl A, Enderle B, Monte E, Kurth J, et al. Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance. Plant Physiol. 2019;: pubmed publisher
    ..However, pif and csn mutants, as well as cop1, cry1 cry2 and phyA phyB mutants, do not share the pp7l photosynthesis phenotype...
  20. Sheerin D, Hiltbrunner A. Molecular mechanisms and ecological function of far-red light signalling. Plant Cell Environ. 2017;40:2509-2529 pubmed publisher
    ..act on two primary pathways within the nucleus; suppression of the E3 ubiquitin ligase complex CUL4/DDB1COP1/SPA and inactivation of the PHYTOCHROME INTERACTING FACTOR (PIF) family of bHLH transcription factors...
  21. Mao K, Wang L, Li Y, Wu R. Molecular Cloning and Functional Analysis of UV RESISTANCE LOCUS 8 (PeUVR8) from Populus euphratica. PLoS ONE. 2015;10:e0132390 pubmed publisher
    ..chromosome condensation 1 (RCC1) repeats and the region 27 amino acids from the C terminus (C27) that interact with COP1 (CONSTITUTIVELY PHOTOMORPHOGENIC1)...
  22. Menon C, Sheerin D, Hiltbrunner A. SPA proteins: SPAnning the gap between visible light and gene expression. Planta. 2016;244:297-312 pubmed publisher
    ..The SPA protein family acts in complex with the E3 ubiquitin ligase COP1 to target positive regulators of light responses for degradation by the 26S proteasome to suppress photomorphogenic ..
  23. Li J, He Y, Zhou L, Liu Y, Jiang M, Ren L, et al. Transcriptome profiling of genes related to light-induced anthocyanin biosynthesis in eggplant (Solanum melongena L.) before purple color becomes evident. BMC Genomics. 2018;19:201 pubmed publisher
    ..The light signal transduction elements, COP1 and two SPAs, might be responsible for anthocyanin biosynthesis regulation...
  24. Zhao W, Guan C, Feng J, Liang Y, Zhan N, Zuo J, et al. The Arabidopsis CROWDED NUCLEI genes regulate seed germination by modulating degradation of ABI5 protein. J Integr Plant Biol. 2016;58:669-78 pubmed publisher
    ..ABI5 protein localizes in nuclear bodies, along with AFP, COP1, and SIZ1, and was degraded through the 26S proteasome pathway...
  25. Dohmann E, Levesque M, De Veylder L, Reichardt I, Jurgens G, Schmid M, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development. 2008;135:2013-22 pubmed publisher
    ..is also apparent in mutants of the NEDD8 conjugation pathway and in mutants of the E3 ligase subunits CULLIN4, COP1 and DET1, which share phenotypes with csn mutants...
  26. Kim S, Lee D, Lee J, Song H, Kim H, Kim K. Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25. Mol Cell Biol. 2015;35:1754-62 pubmed publisher
    ..2 (VRK2) downregulates TRiC protein levels through the ubiquitin-proteasome system by recruiting the E3 ligase COP1. However, although VRK2 activity was necessary in TRiC downregulation, the phosphorylated substrate was not ..
  27. Eprintsev A, Fedorin D, Cherkasskikh M, Igamberdiev A. Expression of succinate dehydrogenase and fumarase genes in maize leaves is mediated by cryptochrome. J Plant Physiol. 2018;221:81-84 pubmed publisher
    ..The blue light effect was probably mediated by transcription factors COP1 and HY5, with the expression of the latter increased upon blue light treatment...
  28. Zhou T, Meng L, Ma Y, Liu Q, Zhang Y, Yang Z, et al. Overexpression of sweet sorghum cryptochrome 1a confers hypersensitivity to blue light, abscisic acid and salinity in Arabidopsis. Plant Cell Rep. 2018;37:251-264 pubmed publisher
    ..SbCRY1a interacted directly with a putative RING E3 ubiquitin ligase constitutive photomorphogenesis 1 (COP1) from sweet sorghum (SbCOP1) instead of SbSPA1 to suppress SbCOP1-SbHY5 interaction responding to blue light...
  29. Guo X, Yu C, Luo L, Wan H, Zhen N, Xu T, et al. Transcriptome of the floral transition in Rosa chinensis 'Old Blush'. BMC Genomics. 2017;18:199 pubmed publisher
    ..Additionally, FRI, FY, DRM1, ELIP, COP1, CO, and COL16 are involved in the circadian clock and autonomous pathway, respectively, and they play a positively ..
  30. Hill R, Madureira P, Ferreira B, Baptista I, Machado S, Colaço L, et al. TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT. Nat Commun. 2017;8:14687 pubmed publisher
    ..Ectopic or intrinsic high expression of TRIB2 induces drug resistance by promoting phospho-AKT (at Ser473) via its COP1 domain...
  31. Mlynarczyk C, FÃ¥hraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A). Nat Commun. 2014;5:5067 pubmed publisher
    ..This prevents p21 from promoting COP1-mediated 14-3-3σ degradation and leads to G2 arrest...
  32. Moriconi V, Binkert M, Costigliolo C, Sellaro R, Ulm R, Casal J. Perception of Sunflecks by the UV-B Photoreceptor UV RESISTANCE LOCUS8. Plant Physiol. 2018;177:75-81 pubmed publisher
    ..UVR8 was also required for normal nuclear dynamics of CONSTITUTIVELY PHOTOMORPHOGENIC1. We propose that UVR8 plays an important role in the plant perception of and response to sunflecks. ..
  33. Yu Y, Huang R. Integration of Ethylene and Light Signaling Affects Hypocotyl Growth in Arabidopsis. Front Plant Sci. 2017;8:57 pubmed publisher
    ..Moreover, CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) and PHYTOCHROME B (phyB) mediate the light-suppressed ethylene response in different ways...
  34. Hajdu A, Ádám Ã, Sheerin D, Dobos O, Bernula P, Hiltbrunner A, et al. High-level expression and phosphorylation of phytochrome B modulates flowering time in Arabidopsis. Plant J. 2015;83:794-805 pubmed publisher
    ..CO in the evening by attenuating the activity of the CONSTITUTIVE PHOTOMORPHOGENIC 1-SUPPRESSOR OF PHYA-105 1 (COP1-SPA1) ubiquitin ligase complex, which promotes turnover of CO...
  35. Ulm R, Jenkins G. Q&A: How do plants sense and respond to UV-B radiation?. BMC Biol. 2015;13:45 pubmed publisher
    ..absorption by a UVR8 homodimer leads to UVR8 monomerization and interaction with the downstream signaling factor COP1. This then initiates changes in gene expression, which lead to several metabolic and morphological alterations...
  36. Murphy J, Nakatani Y, Jamieson S, Dai W, Lucet I, Mace P. Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase. Structure. 2015;23:2111-21 pubmed publisher
    ..Tribbles pseudokinases govern levels of C/EBPs by recruiting them to the COP1 ubiquitin ligase for ubiquitination...
  37. Du C, Wu H, Leng R. UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget. 2016;7:2823-36 pubmed publisher
    ..In this study, we studied the kinetics of UBE4B, Hdm2, Pirh2, Cop1 and CHIP induction in response to p53 activation...
  38. Shi H, Liu R, Xue C, Shen X, Wei N, Deng X, et al. Seedlings Transduce the Depth and Mechanical Pressure of Covering Soil Using COP1 and Ethylene to Regulate EBF1/EBF2 for Soil Emergence. Curr Biol. 2016;26:139-149 pubmed publisher
    ..Here, we report that constitutive photomorphogenesis 1 (COP1), a central repressor of light signaling, is a key component required for seedlings to sense the depth of soil ..
  39. Zhang Y, Yokoyama S, Herriges J, Zhang Z, Young R, Verheyden J, et al. E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. Proc Natl Acad Sci U S A. 2016;113:7557-62 pubmed publisher
    ..Ring finger and WD domain 2 (RFWD2, also termed COP1) is an E3 ubiquitin ligase that modifies specific target proteins, priming their degradation via ..
  40. Ling J, Li J, Zhu D, Deng X. Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness. Proc Natl Acad Sci U S A. 2017;114:3539-3544 pubmed publisher
    The E3 ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) has been known to mediate key signaling factors for degradation via the ubiquitin/26S proteasome pathway in both plants and animals...
  41. Ka W, Cho S, Chun B, Byun S, Ahn J. The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines. Breast Cancer. 2018;25:529-538 pubmed publisher
    The E3 ubiquitin ligase constitutive photomorphogenic 1 (COP1) mediates cell survival, growth, and development, and interacts with the tumor suppressor protein p53 to induce its ubiquitination and degradation...
  42. Tilbrook K, Dubois M, Crocco C, Yin R, Chappuis R, Allorent G, et al. UV-B Perception and Acclimation in Chlamydomonas reinhardtii. Plant Cell. 2016;28:966-83 pubmed publisher
    ..we identified Chlamydomonas orthologs of UVR8 and the key signaling factor CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)...
  43. Kim S, Kim H, Chung S, Lee J. DHU1 negatively regulates UV-B signaling via its direct interaction with COP1 and RUP1. Biochem Biophys Res Commun. 2017;491:285-290 pubmed publisher
    ..Yeast two hybrid assay results suggested that DHU1 directly interacts with COP1 and RUP1, implying a functional connection with both COP1 and RUP1...
  44. Mariz Ponte N, Mendes R, Sario S, Ferreira de Oliveira J, Melo P, Santos C. Tomato plants use non-enzymatic antioxidant pathways to cope with moderate UV-A/B irradiation: A contribution to the use of UV-A/B in horticulture. J Plant Physiol. 2018;221:32-42 pubmed publisher
    ..UV-B caused moreover an increase in the expression of hy5, of HY5 repressor cop1 and of a repressor of COP1, uvr8...
  45. Mendoza M, Mandani G, Momand J. The MDM2 gene family. Biomol Concepts. 2014;5:9-19 pubmed publisher
    ..Other RING domain E3 ubiquitin ligases that target p53 are COP1, Pirh2, and MSL2...
  46. Chen S, Lory N, Stauber J, Hoecker U. Photoreceptor Specificity in the Light-Induced and COP1-Mediated Rapid Degradation of the Repressor of Photomorphogenesis SPA2 in Arabidopsis. PLoS Genet. 2015;11:e1005516 pubmed publisher
    The Arabidopsis COP1/SPA E3 ubiquitin ligase is a key negative regulator that represses light signaling in darkness by targeting transcription factors involved in the light response for degradation...
  47. Xu X, Paik I, Zhu L, Huq E. Illuminating Progress in Phytochrome-Mediated Light Signaling Pathways. Trends Plant Sci. 2015;20:641-50 pubmed publisher
    ..light, a better view of how phytochromes inhibit another key negative regulator, CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), and an understanding of why plants evolved multiple negative regulators to repress photomorphogenesis in darkness...
  48. Kim J, Song K, Park E, Kim K, Bae G, Choi G. Epidermal Phytochrome B Inhibits Hypocotyl Negative Gravitropism Non-Cell-Autonomously. Plant Cell. 2016;28:2770-2785 pubmed
    ..Since phytochromes induce light responses by inhibiting PIFs and the COP1-SPA ubiquitin E3 ligase complex in the nucleus, we asked whether phyB can cell autonomously inhibit hypocotyl ..
  49. Lin F, Xu D, Jiang Y, Chen H, Fan L, Holm M, et al. Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis. Proc Natl Acad Sci U S A. 2017;114:6617-6622 pubmed publisher
    CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans...
  50. Yu Y, Wang J, Shi H, Gu J, Dong J, Deng X, et al. Salt Stress and Ethylene Antagonistically Regulate Nucleocytoplasmic Partitioning of COP1 to Control Seed Germination. Plant Physiol. 2016;170:2340-50 pubmed publisher
    ..Here, we report that the Arabidopsis (Arabidopsis thaliana) CONSTITUTIVE PHOTOMORPHOGENESIS1 (COP1) counteracts SSG Genetic assays provide evidence that SSG in loss of function of the COP1 mutant was stronger than ..
  51. Lin X, Niu D, Hu Z, Kim D, Jin Y, Cai B, et al. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity. PLoS Genet. 2016;12:e1006016 pubmed publisher
    b>COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown...
  52. Ren C, Zhu X, Zhang P, Gong Q. Arabidopsis COP1-interacting protein 1 is a positive regulator of ABA response. Biochem Biophys Res Commun. 2016;477:847-853 pubmed publisher
    b>COP1-interacting protein 1 (CIP1, At5g41790) was the first reported interacting protein for CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) of Arabidopsis; however its physiological function has remained unknown for two decades...
  53. Heilmann M, Velanis C, Cloix C, Smith B, Christie J, Jenkins G. Dimer/monomer status and in vivo function of salt-bridge mutants of the plant UV-B photoreceptor UVR8. Plant J. 2016;88:71-81 pubmed publisher
    ..causes rapid dissociation of dimeric UVR8 into monomers that interact with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) to initiate signal transduction...
  54. Pham V, Kathare P, Huq E. Phytochromes and Phytochrome Interacting Factors. Plant Physiol. 2018;176:1025-1038 pubmed publisher
    ..and four families of ubiquitin ligases (SCFEBF1/2, CUL3LRB, CUL3BOP, and CUL4COP1-SPA) that regulate PIF abundance both in dark and light conditions...
  55. Tao R, Bai S, Ni J, Yang Q, Zhao Y, Teng Y. The blue light signal transduction pathway is involved in anthocyanin accumulation in 'Red Zaosu' pear. Planta. 2018;248:37-48 pubmed publisher
    ..In summary, our results preliminarily revealed that the conserved blue light signal transduction module CRY-COP1-HY5 contributed to the anthocyanin biosynthesis induced by blue light in red pear...
  56. Pick E, Lau O, Tsuge T, Menon S, Tong Y, Dohmae N, et al. Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. Mol Cell Biol. 2007;27:4708-19 pubmed
    ..Overexpression of DET1 inhibits UV-induced CDT1 degradation in cultured cells. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism. ..
  57. Li J, Wang L, Xiao R, Pan Q, Huang H, Kuang R. High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer. Tumour Biol. 2016;37:8917-22 pubmed publisher
    The present study was to investigate the expression and prognostic value of constitutive photomorphogenic 1 (COP1) in bladder cancer...
  58. Kim J, Song J, Seo H. Post-translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions. FEBS Open Bio. 2017;7:1622-1634 pubmed publisher
    ..ubiquitination was induced by exposure to heat stress in transgenic plants overexpressing the E3 ubiquitin ligase COP1. In addition, AtSIZ1 ubiquitination was strongly enhanced in transgenic plants overexpressing SUMO isopeptidase ..
  59. Swain S, Jiang H, Hsieh H. FAR-RED INSENSITIVE 219/JAR1 Contributes to Shade Avoidance Responses of Arabidopsis Seedlings by Modulating Key Shade Signaling Components. Front Plant Sci. 2017;8:1901 pubmed publisher
    ..Furthermore, the protein level of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) was affected in both fin219 mutants and overexpression lines as compared with the wild type under shade...
  60. Fazekas B, Polyánka H, Bebes A, Tax G, Szabó K, Farkas K, et al. UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes. J Photochem Photobiol B. 2014;140:215-22 pubmed publisher
    ..have previously demonstrated that the human ortholog of the Arabidopsis thaliana constitutive photomorphogenesis 1 (COP1) protein, huCOP1, is expressed in keratinocytes in a UVB-regulated manner and is a negative regulator of p53 as a ..
  61. Fu C, Gong Y, Shi X, Shi H, Wan Y, Wu Q, et al. Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity. Oncol Rep. 2016;35:1493-500 pubmed publisher
    ..The constitutively photomorphogenic 1 (COP1), as an E3 ubiquitin ligase, is involved in many biological processes in mammalian cells, but its role in chronic ..
  62. Carrero Z, Kollareddy M, Chauhan K, Ramakrishnan G, Martinez L. Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation. Oncotarget. 2016;7:12554-67 pubmed publisher
    ..We observed that knockdown of the constitutive photomorphogenesis protein 1 (COP1) and its binding partner De-etiolated 1 (DET1) significantly increased ETS2 stability, and conversely, their ..
  63. Kinyo A, Kiss László Z, Hambalkó S, Bebes A, Kiss M, Szell M, et al. COP1 contributes to UVB-induced signaling in human keratinocytes. J Invest Dermatol. 2010;130:541-5 pubmed publisher
    ..Finally, we show that gene-specific silencing of huCOP1 induces the accumulation of the tumor suppressor p53 protein, which is further increased after UVB irradiation. ..
  64. Kobayashi S, Yoneda Kato N, Itahara N, Yoshida A, Kato J. The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy. BMC Biochem. 2013;14:1 pubmed publisher
    The ubiquitin ligase COP1, COnstitutively Photomorphogenic 1, functions in many biological responses in mammalian cells, but its downstream pathway remains unclear...
  65. Choi H, Phan L, Chou P, Su C, Yeung S, Chen J, et al. COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth. Oncotarget. 2015;6:19721-34 pubmed
    ..Constitutive photomorphogenic 1 (COP1) is a RING-containing E3 ubiquitin ligase involved in regulating important target proteins for cell growth, but its ..
  66. Yi C, Li S, Chen X, Wiemer E, Wang J, Wei N, et al. Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells. Cancer Res. 2005;65:5835-40 pubmed
    Constitutively photomorphogenic 1 (COP1), a RING finger ubiquitin ligase with substrates including c-Jun and p53, was recently found to be overexpressed in a number of breast and ovarian tumor samples...
  67. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher
    ..ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase component, leading to their destruction...
  68. Fazekas B, Carty M, Nemeth I, Kemeny L, Szell M, Adam E. HuCOP1 contributes to the regulation of DNA repair in keratinocytes. Mol Cell Biochem. 2017;427:103-109 pubmed publisher
    ..These protein level changes lead to increased sensitivity toward cisplatin treatment, implicating that huCOP1 plays a positive role in maintaining genome integrity in human keratinocytes. ..
  69. Gangappa S, Kumar S. DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms. Cell Rep. 2017;18:344-351 pubmed publisher
    ..DE-ETIOLATED 1 (DET1) and CONSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1), key regulators of light signaling, have been proposed to control thermosensory growth by transcriptional ..
  70. Xiao J, Yang S, Shen P, Wang Y, Sun H, Ji F, et al. Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer. Biochem Biophys Res Commun. 2017;486:1062-1068 pubmed publisher
    ..of ERK kinase led to the phosphorylation of ETV4 at Ser73 and the ETV4 phosphorylation could block its binding to COP1, thereby stabilized ETV4 via avoiding its ubiquitination degradation...
  71. Kim S, Park D, Lee D, Kim W, Jeong Y, Lee J, et al. Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC. Mol Cell Biol. 2014;34:643-52 pubmed publisher
    ..The VRK2-mediated reduction of TRiC protein levels was subsequent to the recruitment of COP1 E3 ligase...
  72. Shin S, Kim S, Kim H, Jeon S, Sim S, Ryu G, et al. Isolation of three B-box zinc finger proteins that interact with STF1 and COP1 defines a HY5/COP1 interaction network involved in light control of development in soybean. Biochem Biophys Res Commun. 2016;478:1080-6 pubmed publisher
    ..In addition, we identified an interaction between soybean COP1 (GmCOP1) and GmSTO and GmSTH, as well as STF1, which strongly suggests the presence of a similar regulatory circuit ..
  73. Kim J, Song J, Seo H. COP1 regulates plant growth and development in response to light at the post-translational level. J Exp Bot. 2017;68:4737-4748 pubmed publisher
    ..b>COP1, an E3 ubiquitin ligase, regulates light signaling by mediating the ubiquitination and subsequent proteasomal ..
  74. Wan L, Zhang R, Peng Z, Sun J, Zhang W. MicroRNA-103 confers the resistance to long-treatment of Adriamycin to human leukemia cells by regulation of COP1. J Cell Biochem. 2017;: pubmed publisher
    ..Increasing evidences suggested that microRNAs (miRNAs) were associated with cancer chemo-resistance. Here, we aimed to explore the possible mechanism of miR-103 affected resistance to ADR in AML cells...
  75. Gao L, Li Y, Shen Z, Han R. Responses of He-Ne laser on agronomic traits and the crosstalk between UVR8 signaling and phytochrome B signaling pathway in Arabidopsis thaliana subjected to supplementary ultraviolet-B (UV-B) stress. Protoplasma. 2018;255:761-771 pubmed publisher
    ..The expression of UVR8, phytochrome B (PhyB), and their mediated signal responsive genes such as COP1, HY5, and CHS were also significantly upregulated in plants with the laser irradiation compared with other groups ..
  76. Yamada T, Christov K, Shilkaitis A, Bratescu L, Green A, Santini S, et al. p28, a first in class peptide inhibitor of cop1 binding to p53. Br J Cancer. 2013;108:2495-504 pubmed publisher
    ..p28 decreased the level of the E3 ligase COP1 >80%, in p53wt and p53mut cells with no decrease in COP1 in p53dom/neg or p53null cells...
  77. Yoshida A, Kato J, Nakamae I, Yoneda Kato N. COP1 targets C/EBP? for degradation and induces acute myeloid leukemia via Trib1. Blood. 2013;122:1750-60 pubmed publisher
    The ubiquitin ligase constitutively photomorphogenic 1 (COP1) is involved in many biological responses in mammalian cells, but its role in tumorigenesis remains unclear...
  78. Choi H, Guma S, Fang L, Phan L, Ivan C, Baggerly K, et al. Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis. Cell Cycle. 2015;14:2265-73 pubmed publisher
    ..Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase associating with COP9 signalosome to regulate important target proteins for cell growth...
  79. Su C, Zhao R, Velazquez Torres G, Chen J, Gully C, Yeung S, et al. Nuclear export regulation of COP1 by 14-3-3? in response to DNA damage. Mol Cancer. 2010;9:243 pubmed publisher
    Mammalian constitutive photomorphogenic 1 (COP1) is a p53 E3 ubiquitin ligase involved in regulating p53 protein level...
  80. Dallavalle C, Albino D, Civenni G, Merulla J, Ostano P, Mello Grand M, et al. MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. J Clin Invest. 2016;126:4585-4602 pubmed publisher
    ..We found that miR-424 targets the E3 ubiquitin ligase COP1 and identified STAT3 as a key substrate of COP1 in promoting tumorigenic and cancer stem-like properties in ..
  81. Ghosh M, Niyogi S, Bhattacharyya M, Adak M, Nayak D, Chakrabarti S, et al. Ubiquitin Ligase COP1 Controls Hepatic Fat Metabolism by Targeting ATGL for Degradation. Diabetes. 2016;65:3561-3572 pubmed
    ..We show that E3 ubiquitin ligase COP1 (also known as RFWD2) binds to the consensus VP motif of ATGL and targets it for proteasomal degradation by K-48 linked ..
  82. Durzynska I, Xu X, Adelmant G, Ficarro S, Marto J, Sliz P, et al. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017;25:287-294 pubmed publisher
    ..Here, we show that STK40 interacts with Constitutive Photomorphogenic Protein 1 (COP1), relying primarily on a C-terminal sequence analogous to the motif found in Tribbles ..
  83. Ren W, Sun Y, Cheema S, Du K. Interaction of constitutive photomorphogenesis 1 protein with protein-tyrosine phosphatase 1B suppresses protein-tyrosine phosphatase 1B activity and enhances insulin signaling. J Biol Chem. 2013;288:10902-13 pubmed publisher
    Recent studies reveal that COP1 suppresses the expression of gluconeogenetic genes and prohibits hepatic glucose production...
  84. Xu S, Tong M, Huang J, Zhang Y, Qiao Y, Weng W, et al. TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells. FEBS Lett. 2014;588:4334-41 pubmed publisher
    ..TRIB2 associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP), COP1 and Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4/β-Catenin expression, and these effects could ..
  85. Legris M, Nieto C, Sellaro R, Prat S, Casal J. Perception and signalling of light and temperature cues in plants. Plant J. 2017;90:683-697 pubmed publisher
    ..two branches, one involving PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and the other CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) and ELONGATED HYPOCOTYL 5 (HY5)...
  86. Xu X, Kathare P, Pham V, Bu Q, Nguyen A, Huq E. Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlies photomorphogenic development in Arabidopsis. Development. 2017;144:1831-1840 pubmed publisher
    ..PIF1 enhances the poly-ubiquitylation of HFR1 by COP1 in vivo and in vitro In addition, the reciprocal co-degradation of PIF1 and HFR1 is dependent on the ..
  87. Ta L, Xuan C, Xing N, Zhu X. COP1 is downregulated in renal cell carcinoma (RCC) and inhibits the migration of RCC ACHN cells in vitro. Mol Med Rep. 2016;14:1371-8 pubmed publisher
    Constitutive photomorphogenic 1 (COP1) belongs to the COP?de-etiolated (DET)?fusca (FUS) protein family and has been demonstrated to suppress prostate adenocarcinomas and other types of tumor, such as liver and gastric cancer...
  88. Pan Y, Shi H. Stabilizing the Transcription Factors by E3 Ligase COP1. Trends Plant Sci. 2017;22:999-1001 pubmed publisher
    Photomorphogenesis is oppositely regulated by two groups of transcription factors. CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) degrades the positive factors but stabilizes the negative ones to predominantly repress photomorphogenesis...
  89. Yi C, Wang H, Wei N, Deng X. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biol. 2002;3:30 pubmed
    Constitutive photomorphogenic 1 (COP1) has been defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation...
  90. Holtkotte X, Ponnu J, Ahmad M, Hoecker U. The blue light-induced interaction of cryptochrome 1 with COP1 requires SPA proteins during Arabidopsis light signaling. PLoS Genet. 2017;13:e1007044 pubmed publisher
    ..Arabidopsis photoreceptors CRY1 and CRY2 which subsequently initiate light signal transduction by repressing the COP1/SPA E3 ubiquitin ligase...
  91. Lian N, Liu X, Wang X, Zhou Y, Li H, Li J, et al. COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulating Arabidopsis hypocotyl elongation. Proc Natl Acad Sci U S A. 2017;114:12321-12326 pubmed publisher
    CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), a well-known E3 ubiquitin ligase, functions as a central regulator of plant growth and photomorphogenic development in plants, including hypocotyl elongation...
  92. Kim S, Hwang G, Lee S, Zhu J, Paik I, Nguyen T, et al. High Ambient Temperature Represses Anthocyanin Biosynthesis through Degradation of HY5. Front Plant Sci. 2017;8:1787 pubmed publisher
    ..temperatures repress anthocyanin biosynthesis through the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) and the positive regulator of anthocyanin biosynthesis ELONGATED HYPOCOTYL5 (HY5)...