connective tissue growth factor

Summary

Gene Symbol: connective tissue growth factor
Description: connective tissue growth factor
Alias: CCN2, HCS24, IGFBP8, NOV2, connective tissue growth factor, CCN family member 2, IBP-8, IGF-binding protein 8, IGFBP-8, hypertrophic chondrocyte-specific protein 24, insulin-like growth factor-binding protein 8
Species: human

Top Publications

  1. Capparelli C, Whitaker Menezes D, Guido C, Balliet R, Pestell T, Howell A, et al. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle. 2012;11:2272-84 pubmed publisher
    ..the activation of the TGF-? signaling, with increased transcription of TGF-? target genes, such as connective tissue growth factor (CTGF)...
  2. Phanish M, Winn S, Dockrell M. Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol. 2010;114:e83-92 pubmed publisher
    b>Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases...
  3. Crean J, Finlay D, Murphy M, Moss C, Godson C, Martin F, et al. The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem. 2002;277:44187-94 pubmed
    b>Connective tissue growth factor (CTGF) is a member of an emerging family of immediate-early gene products that coordinate complex biological processes during differentiation and tissue repair...
  4. Brigstock D. Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis. 2002;5:153-65 pubmed
    b>Connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) are prototypical members of the CCN family which also contains nephroblastoma overexpressed (NOV) and Wnt-induced secreted proteins-1, -2 and -3 (WISP-1, -2, -3)...
  5. Schober J, Chen N, Grzeszkiewicz T, Jovanovic I, Emeson E, Ugarova T, et al. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood. 2002;99:4457-65 pubmed
    Cysteine-rich 61 (Cyr61, CCN1) and connective tissue growth factor (CTGF, CCN2) are growth factor-inducible immediate-early gene products found in blood vessel walls and healing cutaneous wounds...
  6. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J. 2002;16:219-21 pubmed
    ..the chondrocyte cDNA library by a yeast two-hybrid system by using VEGF165 as bait and identified connective tissue growth factor (CTGF) as a candidate...
  7. Qi W, Chen X, Polhill T, Sumual S, Twigg S, Gilbert R, et al. TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. Am J Physiol Renal Physiol. 2006;290:F703-9 pubmed
    ..Evidence suggests that connective tissue growth factor (CTGF) is an important downstream mediator of the profibrotic effects of TGF-beta(1)...
  8. Chang Y, Wu X. The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. J Int Med Res. 2009;37:727-36 pubmed
    ..growth factor beta(1) (TGF-beta(1)) plays an important role in corneal scar formation, mediated by connective tissue growth factor (CTGF)...
  9. Wang B, Carter R, Jaffa M, Nakerakanti S, Lackland D, Lopes Virella M, et al. Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes. J Med Genet. 2010;47:391-7 pubmed publisher
    ..It is hypothesised that mutations within the gene encoding connective tissue growth factor (CTGF/CCN2) will increase the propensity of diabetic subjects to develop nephropathy...

More Information

Publications135 found, 100 shown here

  1. Fitzner B, Brock P, Nechutova H, Glass A, Karopka T, Koczan D, et al. Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. Cell Signal. 2007;19:782-90 pubmed
    ..data indicate that IFN-gamma regulates the expression of two autocrine mediators of PSC activation, connective tissue growth factor and endothelin-1, in a transforming growth factor-beta1-antagonistic manner...
  2. Wang Q, Zhang A, Li R, Liu J, Xie J, Deng A, et al. High glucose promotes the CTGF expression in human mesangial cells via serum and glucocorticoid-induced kinase 1 pathway. J Huazhong Univ Sci Technolog Med Sci. 2008;28:508-12 pubmed publisher
    The role of serum and glucocorticoid-induced kinase 1 (SGK1) pathway in the connective tissue growth factor (CTGF) expression was investigated in cultured human mesangial cells (HMCs) under high glucose...
  3. Wu S, Lu C, Dong L, Chen Z. Signal transduction involved in CTGF-induced production of chemokines in mesangial cells. Growth Factors. 2008;26:192-200 pubmed publisher
    This study investigates the regulatory role of connective tissue growth factor (CTGF) on production of fractalkine, monocyte-chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES) in ..
  4. Kovalenko E, Tacke F, Gressner O, Zimmermann H, Lahme B, Janetzko A, et al. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J Viral Hepat. 2009;16:612-20 pubmed publisher
    ..Taken together, serum CTGF is suitable for determination of hepatic fibrosis and most powerful in patients with chronic HCV infection. ..
  5. Gilbert R, Akdeniz A, Weitz S, Usinger W, Molineaux C, Jones S, et al. Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy. Diabetes Care. 2003;26:2632-6 pubmed
    ..In this cross-sectional study, we sought to examine the urinary excretion of the profibrotic cytokine connective tissue growth factor (CTGF) in type 1 diabetic patients with incipient and overt diabetic nephropathy...
  6. Kita T, Hata Y, Kano K, Miura M, Nakao S, Noda Y, et al. Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor. Diabetes. 2007;56:231-8 pubmed
    The critical association of connective tissue growth factor (CTGF), which is thought to be one of the downstream mediators of transforming growth factor-beta (TGF-beta), with vitreoretinal diseases remains to be clarified...
  7. Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, et al. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. Am J Physiol Renal Physiol. 2010;298:F721-33 pubmed publisher
    ..To study the possible pathogenic role of connective tissue growth factor (CTGF) in the relationship of PF and UFF, dialysate CTGF contents (n = 178) and tissue CTGF ..
  8. Uzumcu M, Homsi M, Ball D, Coskun S, Jaroudi K, Hollanders J, et al. Localization of connective tissue growth factor in human uterine tissues. Mol Hum Reprod. 2000;6:1093-8 pubmed
    b>Connective tissue growth factor (CTGF) is a recently described heparin-binding mitogen for fibroblasts and smooth muscle cells...
  9. Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, et al. Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res. 2006;21:1045-59 pubmed
    ..b>Connective tissue growth factor (CTGF/CCN2) is a mediator of local angiogenesis induced by breast cancer, but its role in osteolytic ..
  10. Sa nguanmoo P, Vejchapipat P, Chongsrisawat V, Chirathaworn C, Honsawek S, Theamboonlers A, et al. Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. J Med Assoc Thai. 2007;90:251-7 pubmed
    b>Connective tissue growth factor (CTGF) has been proposed to play a key role in the pathogenesis of hepatic fibrosis in biliary atresia (BA)...
  11. Yang M, Lin B, Chang C, Chen S, Lin S, Kuo M, et al. Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling. Oncogene. 2012;31:2401-11 pubmed publisher
    b>Connective tissue growth factor (CTGF) is a multi-functional secreted protein, and it has been shown either to promote or suppress tumor progression among different kinds of cancers...
  12. Ohgawara T, Kubota S, Kawaki H, Kondo S, Eguchi T, Kurio N, et al. Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene. FEBS Lett. 2009;583:1006-10 pubmed publisher
    We searched for miRNAs that were down-regulated in chondrocytic cells and predicted to target CCN2/connective tissue growth factor (CCN2/CTGF) that promotes endochondral ossification...
  13. Granel B, Argiro L, Hachulla E, Fajardy I, Weiller P, Durand J, et al. Association between a CTGF gene polymorphism and systemic sclerosis in a French population. J Rheumatol. 2010;37:351-8 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) is believed to be a primary mediator of chronic fibrosis...
  14. Kubota S, Kawata K, Yanagita T, Doi H, Kitoh T, Takigawa M. Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. J Biochem. 2004;136:279-82 pubmed
    ..In the present study, we discovered an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process...
  15. Sala Torra O, Gundacker H, Stirewalt D, Ladne P, Pogosova Agadjanyan E, Slovak M, et al. Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia. Blood. 2007;109:3080-3 pubmed
    ..b>Connective tissue growth factor (CTGF) was the highest overexpressed gene in B-cell ALL compared with the other groups, and displayed ..
  16. Chien W, O Kelly J, Lu D, Leiter A, Sohn J, Yin D, et al. Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol. 2011;38:1741-7 pubmed publisher
    b>Connective tissue growth factor (CTGF/CCN2) belongs to the CCN family of matricellular proteins, comprising Cyr61, CTGF, NovH and WISP1-3...
  17. Barbolina M, Adley B, Kelly D, Shepard J, Fought A, Scholtens D, et al. Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Int J Cancer. 2009;125:816-25 pubmed publisher
    ..cDNA microarray analysis indicated a dramatic downregulation of connective tissue growth factor (CTGF) in EOC cells placed in invasion- mimicking conditions (3D Type I collagen)...
  18. McLennan S, Wang X, Moreno V, Yue D, Twigg S. Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology. 2004;145:5646-55 pubmed
    ..b>Connective tissue growth factor (CTGF) expression is increased in diabetic nephropathy and is a downstream mediator of TGF-beta ..
  19. Kobayashi H, Hayashi N, Hayashi K, Yamataka A, Lane G, Miyano T. Connective tissue growth factor and progressive fibrosis in biliary atresia. Pediatr Surg Int. 2005;21:12-6 pubmed
    b>Connective tissue growth factor (CTGF) is a newly described protein that stimulates transforming growth factor-beta1 (TGF-beta1)...
  20. Chien W, Yin D, Gui D, Mori A, Frank J, Said J, et al. Suppression of cell proliferation and signaling transduction by connective tissue growth factor in non-small cell lung cancer cells. Mol Cancer Res. 2006;4:591-8 pubmed
    b>Connective tissue growth factor (CTGF) is a secreted protein that belongs to CCN family. The proteins in this family are implicated in various biological processes, such as angiogenesis, adhesion, migration, and apoptosis...
  21. Liu L, Han Y, Wu S, Lv Z. Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer. World J Gastroenterol. 2008;14:2110-4 pubmed
    To examine the expression of connective tissue growth factor (CTGF), also known as CCN2, in gastric carcinoma (GC), and the correlation between the expression of CTGF, clinicopathologic features and clinical outcomes of patients with GC...
  22. Nishida T, Kubota S, Fukunaga T, Kondo S, Yosimichi G, Nakanishi T, et al. CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol. 2003;196:265-75 pubmed
    b>Connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) plays important roles in the control of the proliferation and differentiation of chondrocytes in vitro...
  23. Hoshijima M, Hattori T, Inoue M, Araki D, Hanagata H, Miyauchi A, et al. CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. FEBS Lett. 2006;580:1376-82 pubmed
    Searching for CCN family protein 2/connective tissue growth factor (CCN2/CTGF) interactive proteins by yeast-two-hybrid screening, we identified fibronectin 1 gene product as a major binding partner of CCN2/CTGF in the chondrosarcoma-..
  24. Wahab N, Schaefer L, Weston B, Yiannikouris O, Wright A, Babelova A, et al. Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Diabetologia. 2005;48:2650-60 pubmed
    ..THBS1, also known as TSP-1), transforming growth factor beta 1 (TGFB1, also known as TGF-beta1) and connective tissue growth factor (CTGF) at each stage of diabetic nephropathy...
  25. Kennedy L, Liu S, Shi wen X, Chen Y, Eastwood M, Sabetkar M, et al. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res. 2007;313:952-64 pubmed
    b>CCN2 is expressed by mesenchymal cells undergoing active tissue remodeling, and is characteristically overexpressed in connective tissue pathologies such as fibrosis and cancer...
  26. Kwon S, Munroe X, Crawley S, Lee H, Spong S, Bradham D, et al. Expression of connective tissue growth factor in pancreatic cancer cell lines. Int J Oncol. 2007;31:693-703 pubmed
    b>Connective tissue growth factor (CTGF/CCN2) is thought to play a role in normal wound repair and bone remodeling, but also promotes fibrosis in several disease processes including diabetic nephropathy, sclerodoma and pancreatitis...
  27. Deng Y, Chen P, Wang Y, Yin D, Koeffler H, Li B, et al. Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem. 2007;282:36571-81 pubmed
    b>Connective tissue growth factor (CTGF or CCN2), a member of the CCN family, is involved in diverse biological processes such as cell adhesion, proliferation, and angiogenesis...
  28. Zhen Y, Ye Y, Yu X, Mai C, Zhou Y, Chen Y, et al. Reduced CTGF expression promotes cell growth, migration, and invasion in nasopharyngeal carcinoma. PLoS ONE. 2014;8:e64976 pubmed publisher
    ..Our study demonstrates that reduced expression of CTGF promoted cell proliferation, migration, invasion and cell cycle progression through FAK/PI3K/AKT, EMT and MMP pathways in NPC. ..
  29. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, et al. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol. 1999;181:153-9 pubmed
    ..such as transforming growth factor-beta (TGF-beta), basic fibroblast growth factor (bFGF), or connective tissue growth factor (CTGF)...
  30. Kikuchi R, Tsuda H, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, et al. Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. Cancer Res. 2007;67:7095-105 pubmed
    b>Connective tissue growth factor (CTGF) is a secreted protein belonging to the CCN family, members of which are implicated in various biological processes. We identified a homozygous loss of CTGF (6q23...
  31. Duisters R, Tijsen A, Schroen B, Leenders J, Lentink V, van der Made I, et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res. 2009;104:170-8, 6p following 178 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an attractive therapeutic ..
  32. Sugioka K, Yoshida K, Kodama A, Mishima H, Abe K, Munakata H, et al. Connective tissue growth factor cooperates with fibronectin in enhancing attachment and migration of corneal epithelial cells. Tohoku J Exp Med. 2010;222:45-50 pubmed
    ..b>Connective tissue growth factor (CTGF) has been linked to wound healing, and fibronectin (FN) is a major component of the ..
  33. Cheng O, Thuillier R, Sampson E, Schultz G, Ruiz P, Zhang X, et al. Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplant. 2006;6:2292-306 pubmed
    ..These animals also showed an increased expression of connective tissue growth factor (CTGF), both systemically and within the graft...
  34. Suk F, Chen C, Lin S, Cheng C, Yen S, Hung L, et al. 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. Toxicol Lett. 2009;187:22-7 pubmed publisher
    ..cytokines expression, such as transforming growth factor-beta (TGF-beta) and its downstream mediator connective tissue growth factor (CTGF)...
  35. Adler S, Schwartz S, Williams M, Arauz Pacheco C, BOLTON W, Lee T, et al. Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria. Clin J Am Soc Nephrol. 2010;5:1420-8 pubmed publisher
    ..with microalbuminuric diabetic kidney disease (DKD) using FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF). CTGF is critically involved in processes of progressive fibrosis, including DKD...
  36. Zeng Z, Yang L, Ding X, Wang W. Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significance. World J Gastroenterol. 2004;10:3414-8 pubmed
    To investigate the expression of cysteine-rich61 (Cyr61), connective tissue growth factor (CTGF) and nephroblastoma overexpressed gene (Nov) in hepatocellular carcinoma (HCC), and to evaluate the relationship between Cyr61, CTGF and Nov ..
  37. Cicha I, Yilmaz A, Klein M, Raithel D, Brigstock D, Daniel W, et al. Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro. Arterioscler Thromb Vasc Biol. 2005;25:1008-13 pubmed
    Atherosclerotic blood vessels overexpress connective tissue growth factor (CTGF) mRNA, but the role of CTGF in atherosclerosis remains controversial...
  38. McKnight A, Savage D, Patterson C, Brady H, Maxwell A. Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy. J Hum Genet. 2006;51:383-6 pubmed
    b>Connective tissue growth factor (CTGF) has been implicated in the pathogenesis of diabetic nephropathy; however, to date there have been no reports of genomic analysis on this gene...
  39. Tam F, Riser B, Meeran K, Rambow J, Pusey C, Frankel A. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Cytokine. 2009;47:37-42 pubmed publisher
    ..However, measurement of urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers has not previously been reported, and neither have two such molecules in ..
  40. Ponticos M, Holmes A, Shi wen X, Leoni P, Khan K, Rajkumar V, et al. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 2009;60:2142-55 pubmed publisher
    b>Connective tissue growth factor (CTGF; CCN2) is overexpressed in systemic sclerosis (SSc) and has been hypothesized to be a key mediator of the pulmonary fibrosis frequently observed in this disease...
  41. Grotendorst G, Rahmanie H, Duncan M. Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation. FASEB J. 2004;18:469-79 pubmed
    ..We propose a model for this process with regard to wound repair and fibrotic lesion formation that is likely applicable to other instances of CTGF action during embryogenesis. ..
  42. Aikawa T, Gunn J, Spong S, Klaus S, Korc M. Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther. 2006;5:1108-16 pubmed
    b>Connective tissue growth factor (CTGF) plays an important role in fibrosis by modulating cell migration and cell growth but may also modify tumor growth and metastasis...
  43. Chu C, Chang C, Prakash E, Kuo M. Connective tissue growth factor (CTGF) and cancer progression. J Biomed Sci. 2008;15:675-85 pubmed publisher
    b>Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-associated proteins encoded by immediate early genes that play various roles in angiogenesis and tumor growth...
  44. Karger A, Fitzner B, Brock P, Sparmann G, Emmrich J, Liebe S, et al. Molecular insights into connective tissue growth factor action in rat pancreatic stellate cells. Cell Signal. 2008;20:1865-72 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) has been suggested to play a major role in fibrogenesis by enhancing PSC activation after ..
  45. Crean J, Furlong F, Mitchell D, McArdle E, Godson C, Martin F. Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1). FASEB J. 2006;20:1712-4 pubmed
    b>Connective tissue growth factor (CTGF/CCN2) is a 38-kDa secreted protein, a prototypic member of the CCN family, which is up-regulated in many diseases, including atherosclerosis, pulmonary fibrosis, and diabetic nephropathy...
  46. Nishida T, Kondo S, Maeda A, Kubota S, Lyons K, Takigawa M. CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. Bone. 2009;44:24-31 pubmed publisher
    ..We have demonstrated that VEGF regulates the expression of CCN2/connective tissue growth factor (CCN2/CTGF) an essential mediator of cartilage development and angiogenesis, suggesting that CCN2 ..
  47. Nakanishi T, Nishida T, Shimo T, Kobayashi K, Kubo T, Tamatani T, et al. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. Endocrinology. 2000;141:264-73 pubmed
    ..HCS-2/8, by differential display PCR and found that its gene, named hcs24, was identical with that of connective tissue growth factor (CTGF)...
  48. Wahab N, Weston B, Mason R. Modulation of the TGFbeta/Smad signaling pathway in mesangial cells by CTGF/CCN2. Exp Cell Res. 2005;307:305-14 pubmed
    ..b>Connective tissue growth factor (CTGF; CCN2) has also been implicated in this, but the molecular mechanism is unknown...
  49. Lin B, Chang C, Chen R, Jeng Y, Liang J, Lee P, et al. Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clin Cancer Res. 2011;17:3077-88 pubmed publisher
    Here, we aimed to investigate the role of connective tissue growth factor (CTGF) in peritoneal carcinomatosis (PC) associated with colorectal cancer (CRC) and to characterize the underlying mechanism of CTGF mediating adhesion...
  50. Leask A. Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis. Keio J Med. 2004;53:74-7 pubmed
    ..b>Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is overexpressed in SSc fibroblasts...
  51. Secker G, Shortt A, Sampson E, Schwarz Q, Schultz G, Daniels J. TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling. Exp Cell Res. 2008;314:131-42 pubmed
    ..b>Connective tissue growth factor (CTGF) is strongly induced by and acts downstream of TGFbeta causing pathophysiology in tissues by ..
  52. Rimon E, Chen B, Shanks A, Nelson D, Sadovsky Y. Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology. 2008;149:2952-8 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) mediates cell injury and fibrosis in diverse tissues...
  53. Dendooven A, Nguyen T, Brosens L, Li D, Tarnow L, Parving H, et al. The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes. J Negat Results Biomed. 2011;10:4 pubmed publisher
    The -945GC polymorphism (rs6918698) in the connective tissue growth factor gene promoter (CTGF/CCN-2) has been associated with end organ damage in systemic sclerosis...
  54. Jia X, Cheng H, Li H, Zhu Y, Li Y, Feng Z, et al. Inhibition of connective tissue growth factor overexpression decreases growth of hepatocellular carcinoma cells in vitro and in vivo. Chin Med J (Engl). 2011;124:3794-9 pubmed
    We have previously found that connective tissue growth factor (CTGF) is highly expressed in a rat model of liver cancer. Here, we examined expression of CTGF in human hepatocellular carcinoma (HCC) cells and its effect on cell growth...
  55. Romão L, Mendes F, Feitosa N, Faria J, Coelho Aguiar J, de Souza J, et al. Connective tissue growth factor (CTGF/CCN2) is negatively regulated during neuron-glioblastoma interaction. PLoS ONE. 2013;8:e55605 pubmed publisher
    Connective-tissue growth factor (CTGF/CCN2) is a matricellular-secreted protein involved in complex processes such as wound healing, angiogenesis, fibrosis and metastasis, in the regulation of cell proliferation, migration and ..
  56. Chang C, Hsu W, Wang C, Chou C, Kuo M, Lin B, et al. Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells. Cancer Res. 2013;73:4147-57 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) is a multifunctional secreted protein that acts as either an oncoprotein or a tumor suppressor ..
  57. Lai D, Ho K, Hao Y, Yang X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res. 2011;71:2728-38 pubmed publisher
  58. Kidd M, Modlin I, Shapiro M, Camp R, Mane S, Usinger W, et al. CTGF, intestinal stellate cells and carcinoid fibrogenesis. World J Gastroenterol. 2007;13:5208-16 pubmed
    ..The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. ..
  59. Gressner O, Gressner A. Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int. 2008;28:1065-79 pubmed publisher
    b>Connective tissue growth factor (CTGF=CCN2), one of six members of cysteine-rich, secreted, heparin-binding proteins with a modular structure, is recognized as an important player in fibrogenic pathways as deduced from findings in non-..
  60. Tan T, Lai C, Huang C, Yang W, Chen H, Hsu H, et al. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. J Cell Biochem. 2009;107:345-56 pubmed publisher
    ..b>Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human ..
  61. Nakata E, Nakanishi T, Kawai A, Asaumi K, Yamaai T, Asano M, et al. Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing. Bone. 2002;31:441-7 pubmed
    Localization and expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing in mouse ribs were investigated...
  62. Li M, Sanchez T, Pappalardo A, Lynch K, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. 2008;6:1649-56 pubmed publisher
    b>Connective tissue growth factor (CTGF), a member of the CCN family of secreted matricellular proteins, regulates fibrosis, angiogenesis, cell proliferation, apoptosis, tumor growth, and metastasis...
  63. Tong Z, Chen R, Alt D, Kemper S, Perbal B, Brigstock D. Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology. 2009;50:939-47 pubmed publisher
    b>Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibrotic disorders and coexpressed with transforming growth factor beta...
  64. Guo F, Carter D, Leask A. Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGF?-dependent mechanism. PLoS ONE. 2011;6:e19756 pubmed publisher
    ..CCN2/connective tissue growth factor is potently induced in fibroblasts during tissue repair and fibrogenesis...
  65. Zhang C, Meng X, Zhu Z, Yang X, Deng A. Role of connective tissue growth factor in renal tubular epithelial-myofibroblast transdifferentiation and extracellular matrix accumulation in vitro. Life Sci. 2004;75:367-79 pubmed
    b>Connective tissue growth factor (CTGF) has been reported to play an important role in mediating the profibrotic effects of transforming growth factor-beta (TGF-beta) in the pathogenesis of renal fibrosis...
  66. Fonseca C, Lindahl G, Ponticos M, Sestini P, Renzoni E, Holmes A, et al. A polymorphism in the CTGF promoter region associated with systemic sclerosis. N Engl J Med. 2007;357:1210-20 pubmed
    ..The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis. ..
  67. Liu L, Li Z, Feng G, You W, Li J. Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer. Pathol Int. 2007;57:712-8 pubmed
    b>Connective tissue growth factor (CTGF) is believed to be a multifunctional signaling modulator involved in a wide variety of biological or pathological processes including carcinogenesis...
  68. Quan T, Shao Y, He T, Voorhees J, Fisher G. Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol. 2010;130:415-24 pubmed publisher
    Reduced production of type I procollagen is a prominent feature of chronologically aged human skin. Connective tissue growth factor (CTGF/CCN2), a downstream target of the transforming growth factor-beta (TGF-beta)/Smad pathway, is ..
  69. Xie J, Xu L, Wu J, Shen Z, Zhao Q, Du Z, et al. Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol. 2010;176:939-51 pubmed publisher
    ..Taken together, we propose that fascin regulates the proliferation and invasiveness of ESCC cells by modulating the expression of CTGF and CYR61 via TGF-beta pathway. ..
  70. Yin D, Chen W, O Kelly J, Lu D, Ham M, Doan N, et al. Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme. Int J Cancer. 2010;127:2257-67 pubmed publisher
    b>Connective tissue growth factor (CTGF or CCN2) is a secreted protein that belongs to the CCN [cysteine-rich CYR61/CTGF/nephroblastoma-overexpressed gene] family...
  71. Ernst A, Campos B, Meier J, Devens F, Liesenberg F, Wolter M, et al. De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures. Oncogene. 2010;29:3411-22 pubmed publisher
    ..Our results suggest that miR-17-92 and its target CTGF mediate effects of differentiation-promoting treatment on glioblastoma cells through multiple regulatory pathways. ..
  72. Cozzolino M, Biondi M, Banfi E, Riser B, Mehmeti F, Cusi D, et al. CCN2 (CTGF) gene polymorphism is a novel prognostic risk factor for cardiovascular outcomes in hemodialysis patients. Blood Purif. 2010;30:272-6 pubmed publisher
    ..CCN2 (connective tissue growth factor/CTGF) is a profibrotic factor that is secreted by endothelial cells, involved in atherogenesis, ..
  73. Alapati D, Rong M, Chen S, Hehre D, Rodriguez M, Lipson K, et al. Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats. Am J Respir Cell Mol Biol. 2011;45:1169-77 pubmed publisher
    ..b>Connective tissue growth factor (CTGF) is a matricellular protein that plays an important role in tissue development and remodeling...
  74. Abraham D, Shiwen X, Black C, Sa S, Xu Y, Leask A. Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem. 2000;275:15220-5 pubmed
    b>Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders, presumably secondary to the activation and production of transforming growth factor-beta (TGF-beta), a key inducer of fibroblast proliferation ..
  75. Oh S, Song S, Seo E, Kim K, Choi S, Suh Y, et al. The expression of connective tissue growth factor in pregnancies complicated by severe preeclampsia or fetal growth restriction. Placenta. 2009;30:981-7 pubmed publisher
    We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR)...
  76. Van Almen G, Verhesen W, van Leeuwen R, van de Vrie M, Eurlings C, Schellings M, et al. MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell. 2011;10:769-79 pubmed publisher
    ..study, we investigated the aging-associated microRNA cluster 17-92, which targets the ECM proteins connective tissue growth factor (CTGF) and thrombospondin-1 (TSP-1)...
  77. Xie S, Sukkar M, Issa R, Oltmanns U, Nicholson A, Chung K. Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2005;288:L68-76 pubmed
    ..an important role in airway remodeling, and the fibrogenic effect of TGF-beta may be mediated through connective tissue growth factor (CTGF) release...
  78. Zhao Z, Ho L, Wang J, Qin W, Festa E, Mobbs C, et al. Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology. FASEB J. 2005;19:2081-2 pubmed
    ..Using genome-wide array technology, we found that connective tissue growth factor (CTGF), a gene product described previously for its involvement in diabetic fibrosis, is elevated in ..
  79. Nguyen T, Tarnow L, Jorsal A, Oliver N, Roestenberg P, Ito Y, et al. Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy. Diabetes Care. 2008;31:1177-82 pubmed publisher
    We evaluated the predictive value of baseline plasma connective tissue growth factor (CTGF) in a prospective study of patients with type 1 diabetes...
  80. Lee H, Bier A, Cazacu S, Finniss S, Xiang C, Twito H, et al. MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor. PLoS ONE. 2013;8:e54652 pubmed publisher
    ..We identified connective tissue growth factor (CTGF) as a novel target of miR-145 in glioma cells; transfection of the cells with this miRNA ..
  81. Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E, Okada Y. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem. 2002;277:36288-95 pubmed
    ..We have recently demonstrated that VEGF(165), one of the VEGF isoforms, binds connective tissue growth factor (CTGF) and that its angiogenic activity is inhibited in the VEGF(165).CTGF complex form (Inoki, I...
  82. Weston B, Wahab N, Mason R. CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol. 2003;14:601-10 pubmed
    ..TGF-beta induces its downstream mediator connective tissue growth factor (CTGF), which stimulates fibronectin matrix synthesis, a process that requires the presence of ..
  83. Yoshida K, Munakata H. Connective tissue growth factor binds to fibronectin through the type I repeat modules and enhances the affinity of fibronectin to fibrin. Biochim Biophys Acta. 2007;1770:672-80 pubmed
    b>Connective tissue growth factor (CTGF) is a member of the CCN family of the cysteine-rich proteins and involved in wound healing and fibrosis...
  84. Chen P, Wang M, Wu S, Su J, Hong C, Chuang S, et al. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. J Cell Sci. 2007;120:2053-65 pubmed
    b>Connective tissue growth factor (CTGF) expression is elevated in advanced stages of breast cancer, but the regulatory role of CTGF in invasive breast cancer cell phenotypes is unclear...
  85. Shi wen X, Leask A, Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 2008;19:133-44 pubmed publisher
    b>Connective tissue growth factor (CTGF, CCN2) is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis...
  86. Kawaguchi Y, Ota Y, Kawamoto M, Ito I, Tsuchiya N, Sugiura T, et al. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. Ann Rheum Dis. 2009;68:1921-4 pubmed publisher
    To validate the association of a single nucleotide polymorphism (SNP) of the connective tissue growth factor gene (CTGF) with susceptibility to systemic sclerosis (SSc) in the Japanese population...
  87. Bergestuen D, Gravning J, Haugaa K, Sahakyan L, Aakhus S, Thiis Evensen E, et al. Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors. BMC Cancer. 2010;10:6 pubmed publisher
    ..Right ventricular (RV) dysfunction due to mural involvement may also be a manifestation. Connective tissue growth factor (CCN2) is elevated in many fibrotic disorders. Its role in carcinoid heart disease is unknown...
  88. Braig S, Wallner S, Junglas B, Fuchshofer R, Bosserhoff A. CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration. Br J Cancer. 2011;105:231-8 pubmed publisher
    ..has been reported before, whereas the expression of an important modulator of these molecules, connective tissue growth factor (CTGF), has not been investigated in melanomas until now...
  89. Gore Hyer E, Shegogue D, Markiewicz M, Lo S, Hazen Martin D, Greene E, et al. TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol. 2002;283:F707-16 pubmed
    Transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) are ubiquitously expressed in various forms of tissue fibrosis, including fibrotic diseases of the kidney...
  90. Utsugi M, Dobashi K, Ishizuka T, Masubuchi K, Shimizu Y, Nakazawa T, et al. C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2003;28:754-61 pubmed
    Many of the fibrogenic effects of transforming growth factor-beta (TGF-beta) might be mediated by connective tissue growth factor (CTGF)...
  91. Hinton D, Spee C, He S, Weitz S, Usinger W, Labree L, et al. Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2004;27:758-64 pubmed
    To evaluate the expression of connective tissue growth factor (CTGF) and its fragments in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to localize CTGF expression in associated preretinal membranes...
  92. Grotendorst G, Duncan M. Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J. 2005;19:729-38 pubmed
    ..Here, we present data about a structure function analysis of connective tissue growth factor (CTGF), a prototypic member of the CCN family, which has been shown to be a downstream mediator of ..