COMT

Summary

Gene Symbol: COMT
Description: catechol-O-methyltransferase
Alias: HEL-S-98n, catechol O-methyltransferase, catechol-O-methyltransferase isoform, epididymis secretory sperm binding protein Li 98n, testicular tissue protein Li 42
Species: human
Products:     COMT

Top Publications

  1. Bialecka M, Kurzawski M, Klodowska Duda G, Opala G, Tan E, Drozdzik M. The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Pharmacogenet Genomics. 2008;18:815-21 pubmed publisher
    Differences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to levodopa or Parkinson's disease (PD) susceptibility...
  2. Roffman J, Gollub R, Calhoun V, Wassink T, Weiss A, Ho B, et al. MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Proc Natl Acad Sci U S A. 2008;105:17573-8 pubmed publisher
    ..The catechol-O-methyltransferase (COMT) 158Val --> Met polymorphism (rs4680), which affects the availability of prefrontal dopamine signaling, ..
  3. George S, Wallace M, Wright T, Moser M, Greenfield W, Sack B, et al. Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings. Pain. 2008;136:53-61 pubmed
    ..investigated whether psychological variables specific to fear-avoidance models and catechol-O-methyltransferase (COMT) genotype influenced pain ratings for a cohort of patients receiving operative treatment of shoulder pain...
  4. Nedic G, Nikolac M, Sviglin K, Muck Seler D, Borovecki F, Pivac N. Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence. Int J Neuropsychopharmacol. 2011;14:377-88 pubmed publisher
    ..The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine...
  5. Amstadter A, Nugent N, Koenen K, Ruggiero K, Acierno R, Galea S, et al. Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry. 2009;72:360-9 pubmed publisher
    ..and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and ..
  6. Loggia M, Jensen K, Gollub R, Wasan A, Edwards R, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS ONE. 2011;6:e27764 pubmed publisher
    ..Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several ..
  7. Nedic G, Nikolac M, Borovecki F, Hajnsek S, Muck Seler D, Pivac N. Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neurosci Lett. 2010;473:216-9 pubmed publisher
    ..The association of a functional common polymorphism in the catechol-o-methyltransferase gene (COMT Val158Met) with smoking behavior has been extensively studied, but with divergent findings...
  8. Gennatas E, Cholfin J, Zhou J, Crawford R, Sasaki D, Karydas A, et al. COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology. 2012;78:1663-9 pubmed publisher
    We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...
  9. Hall K, Nelson C, Davis R, Buring J, Kirsch I, Mittleman M, et al. Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014;34:2160-7 pubmed publisher
    Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways...
  10. Qin X, Peng Q, Qin A, Chen Z, Lin L, Deng Y, et al. Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. Diagn Pathol. 2012;7:136 pubmed publisher
    Catechol-O-methyltransferase (COMT) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (BC) risk...

Detail Information

Publications98

  1. Bialecka M, Kurzawski M, Klodowska Duda G, Opala G, Tan E, Drozdzik M. The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Pharmacogenet Genomics. 2008;18:815-21 pubmed publisher
    Differences in catechol-O-methyltransferase (COMT) activity and genotype may determine individual variations in the therapeutic response to levodopa or Parkinson's disease (PD) susceptibility...
  2. Roffman J, Gollub R, Calhoun V, Wassink T, Weiss A, Ho B, et al. MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Proc Natl Acad Sci U S A. 2008;105:17573-8 pubmed publisher
    ..The catechol-O-methyltransferase (COMT) 158Val --> Met polymorphism (rs4680), which affects the availability of prefrontal dopamine signaling, ..
  3. George S, Wallace M, Wright T, Moser M, Greenfield W, Sack B, et al. Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings. Pain. 2008;136:53-61 pubmed
    ..investigated whether psychological variables specific to fear-avoidance models and catechol-O-methyltransferase (COMT) genotype influenced pain ratings for a cohort of patients receiving operative treatment of shoulder pain...
  4. Nedic G, Nikolac M, Sviglin K, Muck Seler D, Borovecki F, Pivac N. Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence. Int J Neuropsychopharmacol. 2011;14:377-88 pubmed publisher
    ..The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine...
  5. Amstadter A, Nugent N, Koenen K, Ruggiero K, Acierno R, Galea S, et al. Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry. 2009;72:360-9 pubmed publisher
    ..and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and ..
  6. Loggia M, Jensen K, Gollub R, Wasan A, Edwards R, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS ONE. 2011;6:e27764 pubmed publisher
    ..Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several ..
  7. Nedic G, Nikolac M, Borovecki F, Hajnsek S, Muck Seler D, Pivac N. Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neurosci Lett. 2010;473:216-9 pubmed publisher
    ..The association of a functional common polymorphism in the catechol-o-methyltransferase gene (COMT Val158Met) with smoking behavior has been extensively studied, but with divergent findings...
  8. Gennatas E, Cholfin J, Zhou J, Crawford R, Sasaki D, Karydas A, et al. COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology. 2012;78:1663-9 pubmed publisher
    We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...
  9. Hall K, Nelson C, Davis R, Buring J, Kirsch I, Mittleman M, et al. Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014;34:2160-7 pubmed publisher
    Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways...
  10. Qin X, Peng Q, Qin A, Chen Z, Lin L, Deng Y, et al. Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. Diagn Pathol. 2012;7:136 pubmed publisher
    Catechol-O-methyltransferase (COMT) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (BC) risk...
  11. Soeiro de Souza M, Stanford M, Bio D, Machado Vieira R, Moreno R. Association of the COMT Met¹?? allele with trait impulsivity in healthy young adults. Mol Med Rep. 2013;7:1067-72 pubmed publisher
    ..Catechol-O-methyltransferase (COMT) is a key enzyme in the catabolism of DA within the prefrontal cortex (PFC) and has been suggested to play a role ..
  12. Hall K, Lembo A, Kirsch I, Ziogas D, Douaiher J, Jensen K, et al. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS ONE. 2012;7:e48135 pubmed publisher
    ..Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such ..
  13. Hatzimanolis A, Vitoratou S, Mandelli L, Vaiopoulos C, Nearchou F, Stefanis C, et al. Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability. J Affect Disord. 2013;148:316-22 pubmed publisher
    Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders...
  14. Kang J, Kim S, Song Y, Namkoong K, An S. Genetic influence of COMT and BDNF gene polymorphisms on resilience in healthy college students. Neuropsychobiology. 2013;68:174-80 pubmed publisher
    ..We investigated the genetic influence of the catechol-O-methyltransferase (COMT) Val158Met and the brain-derived neurotrophic factor (BDNF) Val66Met for individual differences in resilience in ..
  15. Alemany S, Arias B, Fatjó Vilas M, Villa H, Moya J, Ibáñez M, et al. Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatr Scand. 2014;129:54-62 pubmed publisher
    To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.
  16. Kontis D, Theochari E, Fryssira H, Kleisas S, Sofocleous C, Andreopoulou A, et al. COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study. Neurosci Lett. 2013;537:17-22 pubmed publisher
    The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in ..
  17. Belfer I, Segall S, Lariviere W, Smith S, Dai F, Slade G, et al. Pain modality- and sex-specific effects of COMT genetic functional variants. Pain. 2013;154:1368-76 pubmed publisher
    The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception...
  18. Landau R, Liu S, Blouin J, Carvalho B. The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia. Anesth Analg. 2013;116:386-91 pubmed publisher
    ..472G/A, p.158Val/Met) of the catechol-O-methyltransferase (COMT) gene in women requesting labor analgesia. Labor analgesia was initiated with IV fentanyl 1.5 ?g/kg...
  19. Moreno Galván M, Herrera González N, Robles Pérez V, Velasco Rodríguez J, Tapia Conyer R, Sarti E. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers. 2010;25:157-63 pubmed
    ..Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis...
  20. Mitaki S, Isomura M, Maniwa K, Yamasaki M, Nagai A, Nabika T, et al. Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene. Neurosci Lett. 2013;549:87-91 pubmed publisher
    ..A significant association was found between an SNP in the catechol-O-methyltransferase (COMT) gene (rs4680) encoding the low-activity Met allele and apathy...
  21. Verdejo Garcia A, Fagundo A, Cuenca A, Rodríguez J, Cuyàs E, Langohr K, et al. COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users. Neuropsychopharmacology. 2013;38:1598-606 pubmed publisher
    ..of ?9-tetrahydrocannabinol (THC) exposure and to executive functions in animals: the catechol-O-methyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism...
  22. Goldberg X, Fatjó Vilas M, Alemany S, Nenadic I, Gasto C, Fañanás L. Gene-environment interaction on cognition: a twin study of childhood maltreatment and COMT variability. J Psychiatr Res. 2013;47:989-94 pubmed publisher
    The functional variant Val(158)Met in the coding sequence of COMT gene is involved in the modulation of dopamine availability in the prefrontal cortex in both clinical and general population samples...
  23. Vinkers C, van Gastel W, Schubart C, van Eijk K, Luykx J, van Winkel R, et al. The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹??Met polymorphism. Schizophr Res. 2013;150:303-11 pubmed publisher
    ..In this context, an extensively studied psychosis vulnerability gene is catechol-methyl-transferase (COMT)...
  24. Xiao L, Tong M, Jin Y, Huang W, Li Z. The l58Val/Met polymorphism of catechol-O-methyl transferase gene and prostate cancer risk: a meta-analysis. Mol Biol Rep. 2013;40:1835-41 pubmed publisher
    The association between COMT Val158Met polymorphism and prostate cancer has been evaluated. However, the results of these studies on the association remain conflicting...
  25. Wendt L, Albring A, Benson S, Engler H, Engler A, Hinney A, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS ONE. 2014;9:e107665 pubmed publisher
    ..We focused on the genetic polymorphisms in the catechol-O-methyltransferase (COMT) gene (Val158Met) and analyzed drug specific and general side effects before and after immunosuppressive medication ..
  26. Tunbridge E, Farrell S, Harrison P, Mackay C. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. Neuroimage. 2013;68:49-54 pubmed publisher
    Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance...
  27. Ahlers S, Elens L, van Gulik L, van Schaik R, van Dongen E, Bruins P, et al. The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery. Br J Clin Pharmacol. 2013;75:1506-15 pubmed publisher
    The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli...
  28. Wardle M, de Wit H, Penton Voak I, Lewis G, Munafo M. Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology. 2013;38:1253-63 pubmed publisher
    The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important regulator of dopamine in the prefrontal cortex, an area critical to working memory...
  29. Malloy Diniz L, Lage G, Campos S, de Paula J, de Souza Costa D, Romano Silva M, et al. Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. PLoS ONE. 2013;8:e73509 pubmed publisher
    ..by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met)...
  30. van Amelsvoort T, Zinkstok J, Figee M, Daly E, Morris R, Owen M, et al. Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome. Psychol Med. 2008;38:89-100 pubmed
    ..One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity...
  31. Chen J, Song J, Yuan P, Tian Q, Ji Y, Ren Patterson R, et al. Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J Biol Chem. 2011;286:34752-60 pubmed publisher
    Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens...
  32. Voisey J, Swagell C, Hughes I, Lawford B, Young R, Morris C. HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association. Eur Psychiatry. 2012;27:372-6 pubmed publisher
    Catechol-O-methyl transferase (COMT) encodes an enzyme involved in the metabolism of dopamine and maps to a commonly deleted region that increases schizophrenia risk...
  33. Perroud N, Jaussent I, Guillaume S, Bellivier F, Baud P, Jollant F, et al. COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. Genes Brain Behav. 2010;9:193-202 pubmed publisher
    ..The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gene Val158Met significantly modulated the association between sexual abuse and anger-trait level (P = 0.001)...
  34. Montag C, Buckholtz J, Hartmann P, Merz M, Burk C, Hennig J, et al. COMT genetic variation affects fear processing: psychophysiological evidence. Behav Neurosci. 2008;122:901-9 pubmed publisher
    ..A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural ..
  35. Störmer V, Passow S, Biesenack J, Li S. Dopaminergic and cholinergic modulations of visual-spatial attention and working memory: insights from molecular genetic research and implications for adult cognitive development. Dev Psychol. 2012;48:875-89 pubmed publisher
    ..We report novel data showing an effect of dopamine COMT gene on spatial updating processes in older but not in younger adults, indicating potential magnification of ..
  36. Lim W, Chen Y, Chuah K, Eng P, Leong S, Lim E, et al. Female reproductive factors, gene polymorphisms in the estrogen metabolism pathway, and risk of lung cancer in Chinese women. Am J Epidemiol. 2012;175:492-503 pubmed publisher
    ..and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ER? rs1256049, ER? rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61...
  37. Benedetti F, Barbini B, Bernasconi A, Fulgosi M, Dallaspezia S, Gavinelli C, et al. Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord. 2010;121:68-72 pubmed publisher
    Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity...
  38. Gu Z, Feng X, Dong X, Chan P. Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. Neurosci Lett. 2010;482:31-4 pubmed publisher
    ..Genotypes were determined for SLC6A3 VNTR, COMT Val108/158Met and MAO-B intron13 A/G polymorphisms by PCR-RFLP, DHPLC and sequencing...
  39. McLean S, Diatchenko L, Lee Y, Swor R, Domeier R, Jones J, et al. Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. J Pain. 2011;12:101-7 pubmed publisher
    Genetic variations in the catechol-O-methyltransferase (COMT) gene have been associated with experimental pain and risk of chronic pain development, but no studies have examined genetic predictors of neck pain intensity and other patient ..
  40. Yamano E, Isowa T, Nakano Y, Matsuda F, Hashimoto Tamaoki T, Ohira H, et al. Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population. Compr Psychiatry. 2008;49:503-7 pubmed publisher
    ..with the Temperament and Character Inventory, and 5 polymorphisms in genes of norepinephrine pathways, ADRB1, COMT, PNMT, SLC18A1, and SLC6A2, in 85 Japanese female nursing students...
  41. Wu R, Cheng C, Chen K, Lu S, Shan D, Ho Y, et al. The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology. 2001;56:375-82 pubmed
    Reports suggest that catechol-O-methyltransferase (COMT(L/L)) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD...
  42. Modugno F, Zmuda J, Potter D, Cai C, Ziv E, Cummings S, et al. Estrogen metabolizing polymorphisms and breast cancer risk among older white women. Breast Cancer Res Treat. 2005;93:261-70 pubmed
    ..white women from the Study of Osteoporotic Fractures (SOF) were genotyped for the catechol-O-methyltransferase (COMT) Val108Met polymorphism and the CYP1A1*2C locus...
  43. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine. Eur Psychiatry. 2010;25:476-8 pubmed publisher
    The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity...
  44. Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A. Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth Analg. 2011;112:448-53 pubmed publisher
    ..More studies are needed to characterize the combined effects of multiple genes and demographic as well as clinical variables in predicting the correct morphine dosage and corresponding opioid-related side effects. ..
  45. Holtzer R, Ozelius L, Xue X, Wang T, Lipton R, Verghese J. Differential effects of COMT on gait and executive control in aging. Neurobiol Aging. 2010;31:523-31 pubmed publisher
    ..Because polymorphisms in catechol-O-methyltransferase (COMT) influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity...
  46. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. J Affect Disord. 2010;125:341-4 pubmed publisher
    Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission...
  47. Michaelovsky E, Frisch A, Leor S, Stein D, Danziger Y, Carel C, et al. Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios. Am J Med Genet B Neuropsychiatr Genet. 2005;139B:45-50 pubmed
    ..Previously, we found an association between AN and the 158Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene in a family-based study of 51 Israeli AN trios...
  48. Colilla S, Lerman C, Shields P, Jepson C, Rukstalis M, Berlin J, et al. Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women. Pharmacogenet Genomics. 2005;15:393-8 pubmed
    The Val108/158Met polymorphism in the gene that encodes COMT, a dopamine metabolizing enzyme, results in a three- to four-fold reduction in COMT activity...
  49. Alexander N, Osinsky R, Mueller E, Schmitz A, Guenthert S, Kuepper Y, et al. Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery. Behav Brain Res. 2011;216:53-8 pubmed publisher
    ..investigate combined effects of functional allelic variations that affect dopamine availability in both cortical (COMT Val¹??Met polymorphism) and subcortical (DAT1 VNTR) brain regions on HPA-axis reactivity to psychosocial stress...
  50. Montag C, Hartmann P, Merz M, Burk C, Reuter M. D2 receptor density and prepulse inhibition in humans: negative findings from a molecular genetic approach. Behav Brain Res. 2008;187:428-32 pubmed
    ..a sample of N=800 subjects according to their genotypes we tested the association between the DRD2 Taq Ia and the COMT Val158Met polymorphisms, and the magnitude of the eye-blink reflex in an acoustic PPI paradigm...
  51. Hong C, Thompson H, Jiang C, Hammond G, Tritchler D, Yaffe M, et al. Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer. Cancer Epidemiol Biomarkers Prev. 2003;12:838-47 pubmed
    ..without breast cancer, we examined the relationship of a functional polymorphism in catechol-O-methyltransferase (COMT; VAL-->MET) to mammographic density and other risk factors for breast cancer...
  52. Swart M, Bruggeman R, Larøi F, Alizadeh B, Kema I, Kortekaas R, et al. COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems. Neuroimage. 2011;55:338-44 pubmed publisher
    Genetic variation in the catechol-O-methyltransferase (COMT) Val158Met polymorphism has been shown to influence performance on cognitive and emotional tasks...
  53. Pereira P, Romano Silva M, Bicalho M, de Moraes E, Malloy Diniz L, Pimenta G, et al. Catechol-O-methyltransferase genetic variant associated with the risk of Alzheimer's disease in a Brazilian population. Dement Geriatr Cogn Disord. 2012;34:90-5 pubmed
    The aim of the present study was to examine the association between polymorphism in the catechol-O-methyltransferase(COMT) gene and Alzheimer's disease (AD) in a Brazilian population...
  54. Gaudet M, Bensen J, Schroeder J, Olshan A, Terry M, Eng S, et al. Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat. 2006;99:235-40 pubmed
    The gene encoding catechol-O-methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide polymorphisms (SNPs) that influence enzyme activity...
  55. Urata T, Takahashi N, Hakamata Y, Iijima Y, Kuwahara N, Ozaki N, et al. Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis. Neurosci Lett. 2007;414:209-12 pubmed
    ..The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA ..
  56. Barnett J, Jones P, Robbins T, Muller U. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry. 2007;12:502-9 pubmed
    The catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is hypothesized to affect executive function in patient and control populations...
  57. Savitz J, van der Merwe L, Newman T, Stein D, Ramesar R. Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits. Behav Genet. 2010;40:415-23 pubmed publisher
    ..Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed...
  58. Demetrovics Z, Varga G, Szekely A, Vereczkei A, Csorba J, Balazs H, et al. Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. Compr Psychiatry. 2010;51:510-5 pubmed publisher
    ..Catechol-O-methyltransferase (COMT) plays a vital role in dopamine inactivation, and the Val(158)Met single nucleotide polymorphism (rs4680) in its ..
  59. Horowitz R, Kotler M, Shufman E, Aharoni S, Kremer I, Cohen H, et al. Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study. Am J Med Genet. 2000;96:599-603 pubmed
    ..1997: Am J Med Genet 74:439-442] showed an association between the high activity catechol O-methyltransferase (COMT) polymorphism and polysubstance abuse in a group of North American subjects...
  60. Meyer Lindenberg A, Nichols T, Callicott J, Ding J, Kolachana B, Buckholtz J, et al. Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry. 2006;11:867-77, 797 pubmed
    Catechol-O-methyltransferase (COMT) has been shown to be critical for prefrontal dopamine flux, prefrontal cortex-dependent cognition and activation...
  61. Blasi G, Mattay V, Bertolino A, Elvevåg B, Callicott J, Das S, et al. Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci. 2005;25:5038-45 pubmed
    ..ratio and that dopaminergic tone in the frontal cortex is critically dependent on catechol-O-methyltransferase (COMT)...
  62. Baker K, Baldeweg T, Sivagnanasundaram S, Scambler P, Skuse D. COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol Psychiatry. 2005;58:23-31 pubmed
    ..Presence of the COMT(108/158)Met allele on the single intact chromosome 22 was associated with more marked MMN amplitude reduction and ..
  63. Cheng T, Chen S, Huang C, Fu Y, Yu J, Cheng C, et al. Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility. Int J Cancer. 2005;113:345-53 pubmed
    ..3 genes involved in CE detoxification by conjugation reactions involving methylation (catechol-O-methyltransferase, COMT), sulfation (sulfotransferase 1A1, SULT1A1), or glucuronidation (UDP-glucuronosyltransferase 1A1, UGT1A1), one (..
  64. Barnett J, Heron J, Goldman D, Jones P, Xu K. Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry. 2009;166:909-16 pubmed publisher
    ..A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks...
  65. Akisik E, Dalay N. Functional polymorphism of thymidylate synthase, but not of the COMT and IL-1B genes, is associated with breast cancer. J Clin Lab Anal. 2007;21:97-102 pubmed
    ..No significant difference in either the genotype distribution or the allelic frequencies of the IL-1B and COMT gene polymorphisms was observed between the patient and control groups...
  66. Drabant E, Hariri A, Meyer Lindenberg A, Munoz K, Mattay V, Kolachana B, et al. Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry. 2006;63:1396-406 pubmed
    Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with ..
  67. Okochi T, Ikeda M, Kishi T, Kawashima K, Kinoshita Y, Kitajima T, et al. Meta-analysis of association between genetic variants in COMT and schizophrenia: an update. Schizophr Res. 2009;110:140-8 pubmed publisher
    ..Val108/158Met (rs4680), and haplotypes rs737865-rs4680-rs165599 in the Catechol-O-methyltransferase gene (COMT) have been extensively examined for association to schizophrenia; however, results of replication studies have been ..
  68. Opgen Rhein C, Neuhaus A, Urbanek C, Hahn E, Sander T, Dettling M. Executive attention in schizophrenic males and the impact of COMT Val108/158Met genotype on performance on the attention network test. Schizophr Bull. 2008;34:1231-9 pubmed publisher
    ..genes of schizophrenia, including the functional single-nucleotide polymorphism catechol-o-methyltransferase (COMT) Val108/158Met, with task-dependent, specific effects of Met allele load on cognitive function...
  69. Drury S, Theall K, Smyke A, Keats B, Egger H, Nelson C, et al. Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation. Child Abuse Negl. 2010;34:387-95 pubmed publisher
    To examine the impact of the catechol-O-methyltransferase (COMT) val(158)met allele on depressive symptoms in young children exposed to early severe social deprivation as a result of being raised in institutions...
  70. Winterer G, Musso F, Vucurevic G, Stoeter P, Konrad A, Seker B, et al. COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. Neuroimage. 2006;32:1722-32 pubmed
    Prefrontal dopamine (DA) is catabolized by the COMT (catechol-O-methyltransferase) enzyme...
  71. Cerasa A, Gioia M, Labate A, Liguori M, Lanza P, Quattrone A. Impact of catechol-O-methyltransferase Val(108/158) Met genotype on hippocampal and prefrontal gray matter volume. Neuroreport. 2008;19:405-8 pubmed publisher
    A variation in catechol-O-methyltransferase (COMT) gene (Val(108/158)Met) affects the physiological response of hippocampal-prefrontal circuits, predicts variation in human memory and is associated with increased risk for psychiatric ..
  72. Cote M, Yoo W, Wenzlaff A, Prysak G, Santer S, Claeys G, et al. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis. 2009;30:626-35 pubmed publisher
    ..examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, GSTT1 and GSTP1 Ile105Val...
  73. Reuter M, Montag C, Peters K, Kocher A, Kiefer M. The modulatory influence of the functional COMT Val158Met polymorphism on lexical decisions and semantic priming. Front Hum Neurosci. 2009;3:20 pubmed publisher
    ..Evidence comes from molecular genetics relating the functional COMT Val158Met polymorphism to working memory and set shifting...
  74. Bertocci B, Miggiano V, Da Prada M, Dembic Z, Lahm H, Malherbe P. Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form. Proc Natl Acad Sci U S A. 1991;88:1416-20 pubmed
    ..sequence contains two tryptic peptide sequences (T-22, T-33) found in porcine liver catechol-O-methyltransferase (COMT)...
  75. Foroud T, Wetherill L, Dick D, Hesselbrock V, Nurnberger J, Kramer J, et al. Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. Alcohol Clin Exp Res. 2007;31:1773-9 pubmed
    To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and ..
  76. Golimbet V, Alfimova M, Gritsenko I, Ebstein R. Relationship between dopamine system genes and extraversion and novelty seeking. Neurosci Behav Physiol. 2007;37:601-6 pubmed
    ..The aim of the present work was to seek associations between polymorphisms in the catechol-O-methyltransferase (COMT) and D4 dopamine receptor (DRD4) genes and personality traits in the Russian population...
  77. Goldberg T, Egan M, Gscheidle T, Coppola R, Weickert T, Kolachana B, et al. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry. 2003;60:889-96 pubmed
    ..Participants were genotyped for catechol-O-methyltransferase (COMT) at the Val158Met locus, which has been shown to affect executive cognition and frontal lobe function, likely ..
  78. Thompson J, Sonuga Barke E, Morgan A, Cornforth C, Turic D, Ferguson L, et al. The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. Dev Med Child Neurol. 2012;54:148-54 pubmed publisher
    The functional polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene was analysed to determine its association with maternal stress and childhood total difficulties...
  79. Rissling I, Frauscher B, Kronenberg F, Tafti M, Stiasny Kolster K, Robyr A, et al. Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Sleep. 2006;29:108-11 pubmed
    ..study by our group suggested an association between daytime sleepiness and the catechol-O-methyltransferase (COMT) val158met polymorphism (rs4680) in patients with Parkinson disease (PD)...
  80. Jabbi M, Kema I, van der Pompe G, Te Meerman G, Ormel J, den Boer J. Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response. Psychiatr Genet. 2007;17:183-93 pubmed
  81. Hosak L, Libiger J, Cizek J, Beránek M, Cermakova E. The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results. Neuro Endocrinol Lett. 2006;27:799-802 pubmed
    ..Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation...
  82. Kereszturi E, Tarnok Z, Bognar E, Lakatos K, Farkas L, Gadoros J, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1431-5 pubmed publisher
    ..pharmacogenetic analyses showed significant role of the high activity Val-allele of cathecol-O-methyltransferase (COMT) Val158Met polymorphism in our ADHD population...