Genomes and Genes
Gene Symbol: COLQ
Description: collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Alias: EAD, AChE Q subunit, acetylcholinesterase collagenic tail peptide, acetylcholinesterase-associated collagen, collagenic tail of endplate acetylcholinesterase, single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Publications141 found, 100 shown here
- Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzymeK Ohno
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 95:9654-9. 1998..ACHET) and heteromeric asymmetric forms composed of 1, 2, or 3 tetrameric ACHET attached to a collagenic tail (ColQ). Asymmetric AChE is concentrated at the endplate (EP), where its collagenic tail anchors it into the basal lamina...
- Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic)C Donger
INSERM U153, Group Hospitalier Pitie Salpetriere, France
Am J Hum Genet 63:967-75. 1998..which is normally concentrated at NMJs, is composed of catalytic tetramers associated with a specific collagen, COLQ. In CMS-Ic patients, these collagen-tailed forms are often absent...
- [Enzyme-linked immunosorbent assay using monoclonal antibodies for direct serotyping of enteric adenoviruses in feces]K Takagi
Department of Microbiology, Ehime Prefectural Institute of Public Health
Kansenshogaku Zasshi 65:552-8. 1991..For identification of enteric adenoviruses (EAd) in stool specimens, enzyme-linked immunosorbent assay (ELISA) test using monoclonal antibodies was developed...
- Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletionShelley Camp
University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:79-86. 2005..system, whereas the splice to exon 6 produces a sequence that binds to the structural subunits PRiMA and ColQ, producing AChE expression in brain and muscle...
- The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoringJean Massoulié
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
Chem Biol Interact 157:3-14. 2005..wide variety of oligomeric forms, ranging from monomers to heteromeric assemblies containing the anchoring proteins ColQ (collagen-tailed forms) and PRiMA (membrane-bound tetramers), which constitute the major functional enzyme species ..
- [Epidemiological studies on enteric adenovirus gastroenteritis in children]Y Yamashita
Ehime Prefectural Institute of Public Health
Kansenshogaku Zasshi 69:377-82. 1995Enteric adenoviruses (EAd), adenovirus (Ad) types 40 and 41, have been established as causative agents of gastroenteritis...
- Early afterdepolarizations and arrhythmogenesis. Experimental and clinical aspectsN El-Sherif
Cardiology Division, State University of New York Health Science Center, Brooklyn 11203
Arch Mal Coeur Vaiss 84:227-34. 1991There is growing evidence that early afterdepolarizations (EADs) and EAD-induced triggered activity play a significant role in the clinical syndrome of long QTU and polymorphic ventricular tachyarrhythmias better known as Torsade de ..
- Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles--the role of calcineurin signalingMiha Trinkaus
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 175:45-9. 2008..The latter is due to the absence of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
- Olfactory responses of Ips duplicatus from inner Mongolia, China to nonhost leaf and bark volatilesQ H Zhang
Department of Crop Science, Swedish University of Agricultural Sciences, Alnarp
J Chem Ecol 27:995-1009. 2001..nonhost angiosperm trees were tested on Ips duplicatus by gas chromatographic-electroantennographic detection (GC-EAD) and by pheromone-baited traps in Sweden and Inner Mongolia, China, respectively...
- Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesteraseEmmanuelle Girard
Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
J Mol Neurosci 30:99-100. 2006..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins ColQ (Krejci et al., 1997) and PRiMA (Perrier et al., 2002)...
- Behavioral and electrophysiological responses of Triatoma brasiliensis males to volatiles produced in the metasternal glands of femalesAna C R Vitta
Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas, Centro de Pesquisas Rene Rachou Fiocruz, 30 190 002, Belo Horizonte, Minas Gerais, Brazil
J Chem Ecol 35:1212-21. 2009..In addition, GC-EAD recordings showed that the antennae of males responded to several of the main components of female MG secretions...
- Electroantennographic and behavioral responses of the sphinx moth Manduca sexta to host plant headspace volatilesAnn M Fraser
ARL Division of Neurobiology, University of Arizona, P O Box 210077, Tucson, Arizona 85721 0077, USA
J Chem Ecol 29:1813-33. 2003Coupled gas chromatography with electroantennographic detection (GC-EAD) using antennae of adult female Manduca sexta was employed to screen for olfactory stimulants present in headspace collections from four species of larval host ..
- Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in miceN Ibnou-Zekri
Department of Pathology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
Proc Natl Acad Sci U S A 94:14654-9. 1997..that (i) the development of SLE was almost completely prevented in BXSB (H-2(b)) mice expressing two copies of the Ead transgene at the homozygous level as well as in BXSB H-2(k) (I-E+) congenic mice as for H-2(d) BXSB mice, and (ii) ..
- Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid--an exploratory studyFrank S Rosenthal
School of Health Sciences, Purdue University, 500 Stadium Mall Drive, West Lafayette, IN 47907, USA
J Aerosol Med 20:83-96. 2007..5/FVC), an aerosol-derived measure of pulmonary airspace size (effective airspace diameter, EAD), and an aerosol-derived measure of nonuniform ventilation (aerosol dispersion, AD)...
- The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibersDavid Fedida
Cardiome Pharma Corporation, University of British Columbia, Vancouver, BC, Canada
J Cardiovasc Electrophysiol 17:S71-S78. 2006..of lidocaine, mexiletine, and RSD1235 may result, at least in part, from their ability to inhibit late I(Na) during action potential repolarization, and inhibition of the inward currents contributing to EAD and arrhythmia formation.
- The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat musclesSpela Glisović
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 187:90-5. 2010..The latter is due to the nearly complete suppression of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
- Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalisS Sicouri
Masonic Medical Research Laboratory, Utica, New York 13504
J Cardiovasc Electrophysiol 4:48-58. 1993..Epicardial, M region, and endocardial tissues and cells show distinct, sometimes opposite, responses to a variety of drugs, including those capable of inducing EADs and DADs...
- Volatile emissions from Aesculus hippocastanum induced by mining of larval stages of Cameraria ohridella influence oviposition by conspecific femalesA Bettina Johne
Institute for Forest Zoology and Forest Conservation, Georg August University, Buesgenweg 3, 37077, Goettingen, Germany
J Chem Ecol 32:2303-19. 2006..Utilizing gas chromatography coupled with parallel detection by mass spectrometry and electroantennography (GC-MS/EAD), more than 30 compounds eliciting responses from antennae of C. ohridella were detected...
- Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular blockPeter Milberg
Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
J Cardiovasc Pharmacol 44:278-86. 2004..01), but not in amiodarone-treated hearts (10%; p = ns). Sotalol led to early afterdepolarizations (EAD) and torsade de pointes (TdP) after lowering of potassium concentration (6 of 13 hearts)...
- Evolution of reproductive strategies in the sexually deceptive orchid Ophrys sphegodes: how does flower-specific variation of odor signals influence reproductive success?M Ayasse
Institute of Zoology, University of Vienna, Austria
Evolution 54:1995-2006. 2000..active in male olfactory receptors based on gas chromatography with electroantennographic detection (GC-EAD)...
- The origin of the molecular diversity and functional anchoring of cholinesterasesJean Massoulié
CNRS UMR 8544, Laboratoire de Neurobiologie, Ecole Normale Superieure, Paris, France
Neurosignals 11:130-43. 2002..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins, ColQ and PRiMA...
- Electrophysiological and behavioral responses of Ips duplicatus to aggregation pheromone in Inner Mongolia, China: amitinol as a potential pheromone componentQing He Zhang
Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, 230 53 Alnarp, Sweden
J Chem Ecol 33:1303-15. 2007..gas chromatography-mass spectrometry (GC-MS), coupled gas chromatography-electroantennographic detection (GC-EAD), and field trapping bioassays in Inner Mongolia, China...
- [Organ changes induced by ergot derivative dopamine agonist drugs: time to change treatment guidelines in Parkinson's disease?]J Roth
Centrum extrapyramidových onemocneni, Neurologická klinika 1 LF UK a VFN, Praha
Cas Lek Cesk 144:123-6. 2005..Not to use EAD as the first-line dopamine agonists. B...
- Identification (GC and GC-MS) of unsaturated acetates in Elasmopalpus lignosellus and their biological activity (GC-EAD and EAG)Gulab N Jham
Departamento de Quimica, Universidade Federal de Vicosa, Vicosa, MG, Brazil
J Sep Sci 28:281-5. 2005..Extract 2 was analyzed by gas chromatography (GC) and gas chromatography-electroannetography (GC-EAD) revealing the presence of (Z)-11-HDA and (Z)-9-TDA. In addition, the same compounds elicited a response with the E...
- Spontaneous, electrically, and cesium chloride induced arrhythmia and afterdepolarizations in the rapidly paced dog heartD L Jones
Departments of Physiology and Medicine, University of Western Ontario, London, Ontario, Canada, N6A 5C1
Pacing Clin Electrophysiol 24:474-85. 2001..induced arrhythmia and the susceptibility of the failing dog heart to arrhythmia and early afterdepolarization (EAD) induced triggered activity elicited by exogenous administration of cesium chloride (CsCl)...
- [The effects of calmodulin kinase II inhibitor on ventricular arrhythmias in rabbits with cardiac hypertrophy]Jun Ke
Department of Cardiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhonghua Xin Xue Guan Bing Za Zhi 35:33-6. 2007..To investigate the effect of KN-93, a calmodulin kinase II inhibitor, on ventricular arrhythmias in rabbits with cardiac hypertrophy...
- General food semiochemicals attract omnivorous German cockroaches, Blattella germanicaNooshin Karimifar
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
J Agric Food Chem 59:1330-7. 2011..Coupled gas chromatographic-electroantennographic detection (GC-EAD) and GC-mass spectrometric (MS) analyses of these attractive extracts, or fractions thereof, and of synthetic ..
- Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixturesJeroen Kool
LACDR Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands
J Biomol Screen 12:396-405. 2007A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to ..
- Electrophysiological and behavioral responses of Ips subelongatus to semiochemicals from its hosts, non-hosts, and conspecifics in ChinaQing He Zhang
Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, SE 230 53, Alnarp, Sweden
J Chem Ecol 33:391-404. 2007..were analyzed using both gas chromatographic-electroantennographic detection (GC-EAD) and gas chromatography/mass spectrometry (GC-MS) techniques, and field trapping bioassays in Inner Mongolia, China...
- Reverse and conventional chemical ecology approaches for the development of oviposition attractants for Culex mosquitoesWalter S Leal
Honorary Maeda Duffey Laboratory, Department of Entomology, University of California Davis, Davis, California, United States of America
PLoS ONE 3:e3045. 2008..both CquiOBP1 as a molecular target in binding assays and gas chromatography-electroantennographic detection (GC-EAD), we identified nonanal, trimethylamine (TMA), and skatole as test compounds...
- Aphrodisiac pheromones from the wings of the small cabbage white and large cabbage white butterflies, Pieris rapae and Pieris brassicaeSelma Yildizhan
Institut fur Organische Chemie, Technische Universitat Braunschweig, Hagenring 30, Braunschweig, Germany
Chembiochem 10:1666-77. 2009..activity of the compounds in the extract was tested by coupled gas chromatographic-electroantennographic (GC-EAD) analysis, which showed that both macrolides and the other major components of the wings can be detected by the ..
- Prioritizing environmental health risks in the UAEHenry H Willis
RAND Corporation, Pittsburgh, PA 15213, USA
Risk Anal 30:1842-56. 2010..in the United Arab Emirates (UAE) to inform a strategic planning process led by the Environment Agency-Abu Dhabi (EAD)...
- Volatile attractants for the common bluebottle, Graphium sarpedon nipponum, from the host, Cinnamomum camphoraJing Li
Department of Agriculture, Faculty of Agriculture, Kochi University, Monobe, Nankoku, Japan
Biosci Biotechnol Biochem 74:1987-90. 2010..The volatiles were analyzed by capillary gas chromatography with electro-antennographic detection (GC-EAD)...
- Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and functionG Feng
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
J Cell Biol 144:1349-60. 1999..AChE) occurs in both asymmetric forms, covalently associated with a collagenous subunit called Q (ColQ), and globular forms that may be either soluble or membrane associated...
- Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross-sectional studyA Zutavern
Dr von Haunersches Kinderspital University Children s Hospital, Munich, Germany
Clin Exp Allergy 35:1301-8. 2005..AD can be differentiated into an allergic extrinsic form (EAD) and a non-allergic intrinsic form (IAD)...
- [Distribution and risk factors of steno-occlusive lesions in patients with ischemic cerebrovascular disease]Dou Li
Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China
Zhonghua Yi Xue Za Zhi 88:1158-62. 2008..To investigate the distribution of atherosclerotic steno-occlusive lesions in Chinese patients with ischemic cerebrovascular disease and the risk factors for occlusive lesions of intracranial and extracranial arteries...
- Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramersHe Li
Eppley Institute and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Biochem J 411:425-32. 2008..in the neuromuscular junctions and the central nervous system is anchored to membranes through interactions with ColQ (AChE-associated collagen tail protein) and PRiMA (proline-rich membrane anchor) proteins containing proline-rich ..
- The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumptionFrancoise Imbert-Bismut
Department of Biochemistry, APHP Groupe Hospitalier Pitié Salpétrière, Paris, France
Eur J Gastroenterol Hepatol 21:18-27. 2009The validity of biomarkers of excessive alcohol drinking (EAD) (30 g/day or more), such as carbohydrate-deficient transferrin (CDT%), is confounded by liver disease severity...
- Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexesSteffen Pahlich
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
J Proteome Res 8:4455-65. 2009..belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD) and a C-terminal RNA-binding domain (RBD), which is extensively methylated at arginine residues...
- Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junctionR L Rotundo
Department of Cell Biology and Anatomy, The University of Miami School of Medicine, 1600 N W 10th Avenue, Miami, FL 33136, USA
Chem Biol Interact 175:26-9. 2008The collagen-tailed form of acetylcholinesterase (ColQ-AChE) is the major if not unique form of the enzyme associated with the neuromuscular junction (NMJ)...
- Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbitsYukiko Fukuda
Cardiopulmonary Division of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
J Am Coll Cardiol 43:1090-100. 2004..We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor...
- Neuropathologic substrate of mild cognitive impairmentWilliam R Markesbery
Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
Arch Neurol 63:38-46. 2006To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD).
- Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2Carl Sims
University of Pittsburgh, School of Medicine, Department of Cell Biology and Physiology, Pittsburgh, PA 15261, USA
Circ Res 102:e86-100. 2008..Therefore, sex, age, and regional differences in I(Ca,L) density and in EAD susceptibility were analyzed in epicardial left ventricular myocytes isolated from the apex and base of prepubertal ..
- Aerosol measurement of airspace diameter correlates with morphometry in normal and papain-exposed air dried lungsF S Rosenthal
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Exp Lung Res 25:425-41. 1999Aerosol measures of effective airspace diameter (EAD) were correlated with morphometric parameters in a series of 8 canine lungs, 5 of which had been exposed to papain in order to cause experimental emphysema...
- Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veinsEugene Patterson
University of Oklahoma Health Sciences Center and the DVA Medical Center, Oklahoma City, Oklahoma, USA
J Am Coll Cardiol 47:1196-206. 2006....
- Spontaneous pulmonary vein firing in man: relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitroEugene Patterson
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
J Cardiovasc Electrophysiol 18:1067-75. 2007..Rapid firing originating within pulmonary veins (PVs) initiates atrial fibrillation (AF). The following studies were performed to evaluate spontaneous PV firing in patients with AF to distinguish focal versus reentrant mechanisms...
- [Effects of BmKIM on sodium current of isolated cardiomyocytes, transmembrane action potential and aconitine induced arrhythmia in vivo in rabbits]Teng Wang
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Zhonghua Xin Xue Guan Bing Za Zhi 37:102-7. 2009....
- Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wallG X Yan
Main Line Health Heart Center, Wynnewood, PA, USA
Circulation 103:2851-6. 2001This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide...
- Odor composition of preferred (buffalo and ox) and nonpreferred (waterbuck) hosts of some Savanna tsetse fliesNicholas K Gikonyo
International Centre of Insect Physiology and Ecology, Nairobi, Kenya
J Chem Ecol 28:969-81. 2002..octadecyl bonded) silica and analyzed with a gas chromatography-linked electroantennographic detector (GC-EAD) and, where possible, identified by using gas chromatography-linked mass spectrometry (GC-MS) and chromatographic ..
- CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during Frederick Y Wu
Molecular Virology Laboratories, Department of Pharmacology and Molecular Sciences, School of dicine, The Johns Hopkins University, Baltimore, Maryland 21231 1000, USA
J Virol 78:4847-65. 2004..Finally, double-label immunofluorescence assays suggested that EAD protein expression was activated even better than ZTA expression in latently infected C/EBPalpha-transfected Akata ..
- [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]Kinji Ohno
Division of Neurogenetics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 29:145-51. 2009..1) Defects in choline acetyltransferase reduce acetylcholine contents at the nerve terminal. (2) Collagen Q (ColQ) anchors acetylcholinesterase at the synaptic basal lamina, and its defects cause endplate acetylcholinesterase ..
- Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT ConditionsAlexander Burashnikov
Masonic Medical Research Laboratory, Utica, NY 13501, USA
Circ Arrhythm Electrophysiol 1:202-8. 2008..The present study examines the effect of hyperthermia on transmural dispersion of action potential duration (TD-APD), early afterdepolarization (EAD) activity, and torsade de pointes (TdP) under long-QT conditions.
- [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]Huai Yu Ding
Heart Center, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China
Sheng Li Xue Bao 58:129-35. 2006..a second plateau response could be induced easily, suggesting a strong tendency of early afterdepolarization (EAD) genesis in PVC. Non-selective cation current (I(NSCC)) was first recorded in both LAC and PVC...
- Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's diseaseM A Lovell
Sanders Brown Center on Aging and Departments of Chemistry, Neurology and Pathology, University of Kentucky, Lexington, KY 40536, USA
Neurotox Res 7:265-71. 2005..levels in the HPG, SMTG and CER of 5 subjects with mild cognitive impairment (MCI), 5 subjects with early AD (EAD) and 4 appropriately age-matched controls. Western blot and dot-blot analysis showed statistically significant (p 0...
- Viral vector-mediated [corrected] expression of human collagen Q in cultured cellsMikako Ito
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Japan
Chem Biol Interact 175:346-8. 2008..Collagen Q (ColQ) makes a triple helical structure and anchors the catalytic subunit of acetylcholinesterase (AChE) to the synaptic ..
- Expression and localization of acetylcholinesterase at the neuromuscular junctionRichard L Rotundo
Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
J Neurocytol 32:743-66. 2003..large protein consists of three catalytic tetramers covalently linked to the three-stranded collagen-like tail (ColQ)...
- Composition and electrophysiological activity of constituents identified in male wing gland secretion of the bumblebee parasite Aphomia sociellaBlanka Kalinová
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, CZ 166 10 Praha 6, Czech Republic
J Nat Prod 72:8-13. 2009..gas chromatography, electroantennography (EAG), gas chromatography with electroantennographic detection (GC-EAD), and NMR...
- Training veterinary personnel for effective identification and diagnosis of exotic animal diseasesCarmel M Kerwick
J Vet Med Educ 35:255-61. 2008The requirements for exotic animal disease (EAD) training were considered at a workshop organized for those with responsibilities for EAD response management in the different states of Australia, with the objective of identifying the ..
- Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 modelXiao Qing Quan
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Cardiovasc Electrophysiol 18:1184-9. 2007..This study examined the effects of antiarrhythmic peptide AAP10, a gap junction enhancer, on TDR and induction of TdP in a rabbit LQT3 model...
- (Z,Z)-4,7-tridecadien-(S)-2-yl acetate: sex pheromone of Douglas-fir cone gall midge, Contarinia oregonensisRegine Gries
Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 Canada
J Chem Ecol 28:2283-97. 2002..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of pheromone extract revealed a single compound (A) that elicited responses from male antennae...
- Populations of the gall midge Dasineura oxycoccana on cranberry and blueberry produce and respond to different sex pheromonesSheila M Fitzpatrick
Agriculture and Agri Food Canada, Pacific Agri Food Research Centre, P O Box 1000, Agassiz, BC, V0M 1A0, Canada
J Chem Ecol 39:37-49. 2013..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of pheromone gland extract from the ovipositor of calling CTW females revealed one component (<10 pg ..
- Prediction of early allograft dysfunction using serum phosphorus level in living donor liver transplantationSang Hyun Hong
Department of Anaesthesiology and Pain Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Transpl Int 26:402-10. 2013..We investigated the predictive role of serum phosphorus for early allograft dysfunction (EAD) after living donor liver transplantation (LDLT)...
- Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbitsGong Xin Liu
Cardiovascular Research Centre, Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Physiol 590:1171-80. 2012Early after-depolarization (EAD), or abnormal depolarization during the plateau phase of action potentials, is a hallmark of long-QT syndrome (LQTS)...
- Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activationJin Bae Kim
The Division of Cardiology, Kyung Hee University College of Medicine, 1 Hoegi dong, Dongdaemun Gu, Seoul, Republic of Korea
Toxicol Appl Pharmacol 259:66-73. 2012..Spontaneous early afterdepolarization (EAD) and ventricular tachycardia (VT) were observed in 8 (67%) and 6 (50%) hearts, respectively, versus no spontaneous ..
- Imaging arrhythmogenic calcium signaling in intact heartsPeng Sheng Chen
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, 1800 N Capitol Ave, E475, Indianapolis, IN 46202, USA
Pediatr Cardiol 33:968-74. 2012..Phase 3 EAD is dependent on heterogeneously prolonged action potential duration (APD)...
- [Congenital myasthenic syndromes]Kinji Ohno
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Rinsho Shinkeigaku 52:1159-61. 2012..Third, collagen Q (ColQ) anchors acetylcholinesterase (AChE) to the synaptic basal lamina and mutations in COLQ lead to endplate AChE ..
- Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT?A Sinha
Polyposis Registry, St Mark s Hospital, Harrow, UK
Br J Radiol 85:e254-61. 2012..We aimed to determine whether MRI provides equivalent or better assessment of desmoid tumours than CT, the current first-line investigation...
- Advances and perspectives in mental health: Is psychiatry being stigmatized?R Montenegro
Corporate Secretary of the World Federation for Mental Health, Former President of the Latin American Psychiatric Association, Former President of the Association of Argentinean Psychiatrists
Psychiatrike 22:283-9. 2011..psychiatrists in conjunction with other scientific and humanistic disciplines is being affected by some factswhich ead to its stigmatization. There are both internal and external risks that are affecting the profession...
- Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screeningJonas M Bengtsson
Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden
J Chem Ecol 35:1063-76. 2009..Webb (Malvaceae) for antennal activity using gas chromatograph-coupled electroantennographic detection (GC-EAD). Compounds active in GC-EAD were identified by combined gas chromatography and mass spectrometry (GC-MS)...
- Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibersAlberto Corrias
Computing Laboratory, University of Oxford, Oxford, UK
Am J Physiol Heart Circ Physiol 300:H1806-13. 2011..Repolarization abnormalities such as action potential (AP) prolongation and early afterdeploarizations (EAD) are often observed in vitro upon pharmacological interventions...
- Conductive indium-tin oxide nanowire and nanotube arrays made by electrochemically assisted deposition in template membranes: switching between wire and tube growth modes by surface chemical modification of the templateNina I Kovtyukhova
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Nanoscale 3:1541-52. 2011..from acidic aqueous solutions of inorganic precursors in a simple one-step electrochemically assisted deposition (EAD) process inside Au-plugged anodic aluminium oxide and polycarbonate membranes...
- Synthetic grape volatiles attract mated Lobesia botrana females in laboratory and field bioassaysGianfranco Anfora
IASMA FEM Research and Innovation Centre, San Michele a A, TN, Italy
J Chem Ecol 35:1054-62. 2009..The six major components of the odor profiles that were GC-EAD-active to female antennae included: limonene, 4,8-dimethyl-1,(E)-3,7-nonatriene, (+/-)-linalool, (E)-caryophyllene, ..
- Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayersDavid S Auerbach
Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48108, USA
J Physiol 589:2363-81. 2011..5 protein expression, peak and persistent INa density, A Pupstroke velocity, AP duration, conduction velocity and EAD incidence, as well as reflection incidence (29.2%, n =48 vs. uninfected, 9.4%, n =64; and Ad-GFP, 4.8%, n =21)...
- Comparative GC-EAD responses of a specialist (Microplitis croceipes) and a generalist (Cotesia marginiventris) parasitoid to cotton volatiles induced by two caterpillar speciesEsther Ngumbi
Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, USA
J Chem Ecol 35:1009-20. 2009..and Spodoptera spp. We compared GC-EAD (coupled gas chromatography electroantennogram detection) responses of both parasitoid species to headspace ..
- Formate analogs as antagonists of the sex pheromone of the honeydew moth, Cryptoblabes gnidiella: electrophysiological, behavioral and field evidenceCarolina Sellanes
Laboratorio de Ecología Química, Facultad de Quimica, Universidad de la Republica, Gral Flores 2124, CP 11800 Montevideo, Uruguay
J Chem Ecol 36:1234-40. 2010..In gas chromatography-electroantennogram detection (GC-EAD) studies, both analogs elicited responses from C. gnidiella male antennae...
- Arrhythmogenesis by single ectopic beats originating in the Purkinje systemMakarand Deo
Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA
Am J Physiol Heart Circ Physiol 299:H1002-11. 2010..of tissue conductivity and excitability, as well as interaction with sinus excitation, in determining whether an EAD-induced ectopic beat will establish reentrant activity...
- Acetylcholinesterase associates differently with its anchoring proteins ColQ and PRiMAHiba Noureddine
Laboratoire de Neurobiologie, Centre National de la Recherche Scientifique, UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, Paris, France
J Biol Chem 283:20722-32. 2008..of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor)...
- [Generics of antiepileptic drugs]M Maeder-Ingvar
Unité d épileptologie, Service de Neurologie, Departement des neurosciences cliniques, CHUV, 01011 Lausanne
Rev Med Suisse 6:907-9. 2010Generic substitution of antiepileptic drugs (EAD) have limited use because epilepsy is a chronic disease, seizure recurrence has an important impact of the quality of life and the potential risk of accidents...
- Identification by GC-EAD of the two-component trail-following pheromone of Prorhinotermes simplex (Isoptera, Rhinotermitidae, Prorhinotermitinae)David Sillam-Dussès
Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Praha, Czech Republic
J Insect Physiol 55:751-7. 2009..simplex, P. canalifrons, P. inopinatus). In addition, EAG and GC-EAD experiments with P...
- Disease control options for emergency animal diseases--necessary yet sensitive elimination of diseaseRichard Rubira
Australian Government Department of Agriculture, Fisheries and Forestry, GPO Box 858, Canberra, ACT 2601, Australia
Vet Ital 43:333-48. 2007In the event of any emergency animal disease (EAD) outbreak, the overall aim should be the swift containment and subsequent elimination of the causal agent, whilst maintaining optimal welfare of the affected animal population and ..
- Scent variation and hybridization cause the displacement of a sexually deceptive orchid speciesJohannes Stökl
Institute for Experimental Ecology, University of Ulm, Albert Einstein Allee 11, 89069 Ulm, Germany
Am J Bot 95:472-81. 2008..lupercalis and O. iricolor on Sardinia using behavioral, electrophysiological (GC-EAD), chemical, morphological, and genetic methods (AFLPs)...
- [Anhidrotic ectodermal dysplasia. Rehabilitation]J Fotso
Service de chirurgie maxillofaciale et de chirurgie buccale, Hopitaux Universitaires de Geneve, 25, Rue Micheli du Crest, Geneva, Switzerland
Rev Stomatol Chir Maxillofac 110:50-4. 2009Anhidrotic ectodermal dysplasia (EAD) is an inherited syndrome with an incidence of one per 100,000 live births and is characterized by hypotrichosis, anhidrosis or hypohidrosis, and oligodontia...
- Domain shuffling and module engineering of Listeria phage endolysins for enhanced lytic activity and binding affinityMathias Schmelcher
Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
Microb Biotechnol 4:651-62. 2011..Chimaeras consisting of individual EAD and CBD modules from PlyPSA and Ply118 endolysins with different binding specificity and catalytic activity showed ..
- Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesteraseDong Liang
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, Paris, France
FEBS J 276:94-108. 2009..This t peptide allows their assembly into tetramers associated with the anchoring proteins ColQ and PRiMA...
- Enhanced repolarization capacity: new potential antiarrhythmic strategy based on HERG channel activationG Szabo
Department of Physiology, University of Debrecen, Nagyerdei Krt 98 H 4012 Debrecen, Hungary
Curr Med Chem 18:3607-21. 2011..either by a pathological factor or due to a pharmacological intervention - threatens with an increased risk of EAD generation and the concomitant sudden cardiac death...
- Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atriumYung Kuo Lin
Division of Cardiovascular Medicine, Taipei Medical University, Wan Fang Hospital, Taiwan
Clin Sci (Lond) 122:121-32. 2012..8±0.1 to 1.3±0.2 and 0.8±0.1 Hz at 30 and 60 min respectively (n=8, P<0.005), and induced EAD (early after depolarization) in three (37.5%) of the PVs and DAD (delayed after depolarization) in one (12...
- Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked GlycosylationVicky P Chen
Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology Hong Kong, China
Front Mol Neurosci 4:36. 2011..of AChE T variant are depending primarily on the association of their anchoring partners, either collagen tail (ColQ) or proline-rich membrane anchor (PRiMA)...
- The ZIIR element of the Epstein-Barr virus BZLF1 promoter plays a central role in establishment and maintenance of viral latencyXianming Yu
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1599, USA
J Virol 85:5081-90. 2011..cells infected with ZIIR mutant (ZIIRmt) virus produced at least 20-fold more viral IE Zta and Rta and early (E) EAD protein than did cells infected with the parental wild-type (WT) virus, leading to viral DNA replication and ..
- Dauricine suppressed CsCl-induced early afterdepolarizations and triggered arrhythmias in rabbit heart in vivoJ S Xia
Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China
Zhongguo Yao Li Xue Bao 20:513-6. 1999To study the effect of dauricine on CsCl-induced early afterdepolarizations (EAD) and ventricular arrhythmias in rabbits.
- Limiting role of protein disulfide isomerase in the expression of collagen-tailed acetylcholinesterase forms in muscleCarlos A Ruiz
Department of Cell Biology and Anatomy and the Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
J Biol Chem 284:31753-63. 2009..We show here that the expression of the synaptic collagen-tailed AChE form (ColQ-AChE) in quail muscle cultures can be regulated by muscle activity post-translationally...
- Congenital myasthenic syndromes in childhood: diagnostic and management challengesM Kinali
The Dubowitz Neuromuscular Centre, Great Ormond Street Hospital and Institute of Child Health, University College, London, UK
J Neuroimmunol 201:6-12. 2008..A repetitive CMAP was detected in only one of seven children with a COLQ mutation and neither of the two children with Slow Channel Syndrome mutations...
- [Long-term effect of the beta 2-sympathomimetic formoterol in young smokers--study of duration and site of effect of bronchodilatation using conventional methods of lung function and monodispersed aerosols]R Siekmeier
, GmbH, , Frankfurt/Main
Pneumologie 48:225-30. 1994..spirometry) and an biophysical aerosol measurement method for determining the effective airways dimensions (EAD)...
- Semiochemicals of the Scarabaeinae. VII: Identification and synthesis of EAD-active constituents of abdominal sex attracting secretion of the male dung beetle, Kheper subaeneusB V Burger
Laboratory for Ecological Chemistry, Department of Chemistry, University of Stellenbosch, Stellenbosch 7600, South Africa
J Chem Ecol 28:2527-39. 2002Using gas chromatography with flame ionization detection (FID) and electroantennographic detection (EAD) in parallel, butanoic acid, skatole, and (E)-2,6-dimethyl-6-octen-2-ol were identified as constituents of the abdominal sex-..
- Two novel mutations in the COLQ gene cause endplate acetylcholinesterase deficiencyKeiko Ishigaki
Institut de Myologie, INSERM U 523, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
Neuromuscul Disord 13:236-44. 2003..To date, all reported cases are due to mutations within the gene encoding ColQ, a specific collagen that anchors acetylcholinesterase in the basal lamina at the neuromuscular junction...
- Sex pheromone of horse-chestnut leafminer Camneraria ohridella and its use in a pheromone-based monitoring systemB Kalinová
Department of Natural Products, Insect Chemistry Group, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10 Prague 6, Czech Republic
J Chem Ecol 29:387-404. 2003Gas chromatography combined with electroantennographic detection (GC-EAD), electroantennography (EAG), and wind-tunnel and field experiments were used to reinvestigate the composition of Cameraria ohridella (Lepidoptera, Gracillariidae, ..
- (R)-acetoin-female sex pheromone of the summer chafer Amphimallon solstitiale (L.)Till Tolasch
Institut fur Organische Chemie, Universitat Hamburg, Martin Luther King Platz 6, D 20146 Hamburg, Germany
J Chem Ecol 29:1045-50. 2003..a well known, widely distributed and rather common European scarab beetle, were analyzed by GC-MS and GC-EAD. Acetoin - (R):(S) > 9:1 - as well as 2,3-butanediol - (2R,3R): (2S,3S):meso = 1:1:9 - were present in extracts of ..
- Antennal responses to floral scents in the butterfly Heliconius melpomeneSusanna Andersson
Max Planck Institute of Chemical Ecology, Bioorganics, Beutenberg Campus, Hans Knoll Strasse 8, D 07745 Jena, Germany
J Chem Ecol 29:2319-30. 2003..and synthetic floral scent mixtures were investigated using gas chromatography-electroantennographic detection (GC-EAD). The natural floral scents included those of two tropical plant species, Lantana camara L...
- Sex pheromone of the persimmon fruit moth, Stathmopoda masinissa: identification and laboratory bioassay of (4E, 6Z)-4,6-hexadecadien-1-ol derivativesHideshi Naka
Laboratory of Applied Entomology, Faculty of Agriculture, Gifu University, Gifu 501 1193, Japan
J Chem Ecol 29:2447-59. 2003..EAG)-active components were detected by gas chromatography coupled to an electroantennographic detector (GC-EAD) analysis of a hexane extract of the pheromone glands of the persimmon fruit moth, Stathmopoda masinissa...
- [Comparative anatomical study of three surgical approaches for treating complex posterior urethral stricture]Xiao Ming Zhang
Department of Urology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China
Di Yi Jun Yi Da Xue Xue Bao 24:94-6. 2004..To evaluate the advantages and disadvantages of 3 surgical approaches via superior intermedial margin of the pubis, inferior medial margin of the pubis, and the perineum, respectively, in the treatment of posterior urethral stricture...
- Amyloid beta(1-42) and phosphorylated tau in CSF as markers for early-onset Alzheimer diseaseN S M Schoonenboom
Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 62:1580-4. 2004To determine the diagnostic value of CSF amyloid beta(1-42) (Abeta42), CSF total tau, and CSF tau phosphorylated at threonine-181 (Ptau-181) in early-onset Alzheimer disease (EAD) vs frontotemporal lobar degeneration (FTLD).
- Congenital myasthenic syndromes: progress over the past decadeAndrew G Engel
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
Muscle Nerve 27:4-25. 2003..A basal lamina CMS is caused by mutations in the collagenic tail subunit (ColQ) of the endplate species of acetylcholinesterase that prevent the tail subunit from associating with catalytic ..
- Antiarrhythmic Mechanisms in the Hearts of Hibernating MammalsLai Hua Xie; Fiscal Year: 2010..Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (DAD), and triggered activity (TA), and has been suggested as a potential ..
- Post-transcriptional regulation of synaptic acetylcholinesterase in muscleCarlos Ruiz; Fiscal Year: 2007Synaptic acetylcholinesterase (ColQ-AChE) is localized at the neuromuscular junctions in skeletal muscle. It is a hetero-oligomeric protein formed from 12 catalytic subunits (AChE) and 3 non-catalytic subunits (ColQ)...
- Congenital Myasthenic Syndromes: Pathogenic MechanismsRICARDO ANIBAL MASELLI; Fiscal Year: 2010..receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
- The role of dynamic changes in repolarization and calcium transients in Long QT rBum Rak Choi; Fiscal Year: 2009..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
- The role of dynamic changes in repolarization and calcium transients in Long QT rBum Rak Choi; Fiscal Year: 2010..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
- MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGSDavid Flockhart; Fiscal Year: 2001..perfused heart using the characteristics of the action potential (AP), QT interval and early after depolarization (EAD) occurrence...
- Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell deathCHARLES PAUZA; Fiscal Year: 2007..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
- Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell deathCHARLES PAUZA; Fiscal Year: 2007..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
- Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell deathCHARLES PAUZA; Fiscal Year: 2009..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
- Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell deathC Pauza; Fiscal Year: 2006
- THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASEDonald Leung; Fiscal Year: 2009..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
- THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASEDonald Leung; Fiscal Year: 2007..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
- Fibrillation and DefibrillationPeng Sheng Chen; Fiscal Year: 2010..Our preliminary studies showed that late phase 3 EAD may also play a role in postshock arrhythmias in failing and ischemic hearts...
- CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONSMark Anderson; Fiscal Year: 2007..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
- ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELSDavid Mooney; Fiscal Year: 2007..The successful completion of these aims will ead to new strategies for the regeneration of functional muscle tissue...
- ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELSDavid J Mooney; Fiscal Year: 2010..The successful completion of these aims will ead to new strategies for the regeneration of functional muscle tissue...
- MODULATION OF CLASS III ANTIARRHYTHMIC DRUG EFFECTSMichael Sanguinetti; Fiscal Year: 2000..drugs; 3) to map the binding site on HERG channels for methanesulfonanilides; 4) to determine the mechanism of EAD suppression by an increase in (Mg2+]e in myocytes exposed to selective class III antiarrhythmic drugs; and 5) to ..
- CARDIOPLEGIA AND CORONARY MICROVASCULAR REACTIVITYFrank Sellke; Fiscal Year: 2009..and CPB, a better understandingi of thei regulationi of the (Mronarymicrovasculature of these patients may ead to improved outcomes after cardiac surgery...
- Fax to Quit: Linking Smokers Visiting Clinics to State QuitlinesMichael Fiore; Fiscal Year: 2007..evaluate two forms of Fax to Quit: Fax to Quit alone (FQ) and Fax to Quit plus Enhanced Academic Detailing (FQ + EAD) with EAD comprising ongoing training/technical assistance and performance feedback...
- ELECTRON MICROSCOPY OF MYOPATHIESAndrew Engel; Fiscal Year: 1993..In the newly discovered mitochondrial encephalomyopathy due to coenzyme Q10 deficiency, the hypothesis will be tested that the disorder is caused by a defect in the mitochondrial biosynthesis of coenzyme Q10...
- CONGENITAL MYASTHENIC SYNDROMESAndrew Engel; Fiscal Year: 2001..Moreover, recognition of spontaneous mutations in the EP nicotinic AChR should spur the search for mutations in neuronal nicotinic AChRs and other ligand-gated channels in various neurologic and psychiatric disorders. ..
- ELECTRON MICROSCOPY OF MYOPATHIESAndrew Engel; Fiscal Year: 1980..In carnitine deficiency cultured muscle cells will be studied for a postulated abnormality of carnitine transport. The biochemical basis of an adult onset polyglucosan storage disease will be investigated...
- ELECTRON MICROSCOPY OF MYOPATHIESAndrew Engel; Fiscal Year: 1990..In dermatomyositis the hypothesis will be tested that the pathologic features of the disease are mediated by a circulating autoantibody...
- REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLYRICHARD ROTUNDO; Fiscal Year: 2005..2) We will study the regulation of assembly of the synaptic ColQ AChE form consisting of three tetramers attached to the collagenic tail and the role of transcriptional and post-..
- TRAUMATIC BRAIN INJURY AND CELLULAR HOMEOSTASISStephen Scheff; Fiscal Year: 2003..These studies will significantly enhance our understanding of the mechanisms following TBI and hopefully lead to therapies resulting in increased recovery. ..
- REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLYRICHARD ROTUNDO; Fiscal Year: 2009..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
- Autonomic Nerve Activity and Paroxysmal Atrial FibrillationPeng Sheng Chen; Fiscal Year: 2009..The results will be used to test the hypothesis simultaneous norepinephrine and acetylcholine stimulation in canine PV in vitro promotes triggered activity through Ca transient triggering mechanisms. ..