COLQ

Summary

Gene Symbol: COLQ
Description: collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Alias: EAD, AChE Q subunit, acetylcholinesterase collagenic tail peptide, acetylcholinesterase-associated collagen, collagenic tail of endplate acetylcholinesterase, single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Species: human

Top Publications

  1. pmc Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme
    K Ohno
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 95:9654-9. 1998
  2. pmc Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic)
    C Donger
    INSERM U153, Group Hospitalier Pitie Salpetriere, France
    Am J Hum Genet 63:967-75. 1998
  3. ncbi [Enzyme-linked immunosorbent assay using monoclonal antibodies for direct serotyping of enteric adenoviruses in feces]
    K Takagi
    Department of Microbiology, Ehime Prefectural Institute of Public Health
    Kansenshogaku Zasshi 65:552-8. 1991
  4. ncbi Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion
    Shelley Camp
    University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
    Chem Biol Interact 157:79-86. 2005
  5. ncbi The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring
    Jean Massoulié
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Chem Biol Interact 157:3-14. 2005
  6. ncbi [Epidemiological studies on enteric adenovirus gastroenteritis in children]
    Y Yamashita
    Ehime Prefectural Institute of Public Health
    Kansenshogaku Zasshi 69:377-82. 1995
  7. ncbi Early afterdepolarizations and arrhythmogenesis. Experimental and clinical aspects
    N El-Sherif
    Cardiology Division, State University of New York Health Science Center, Brooklyn 11203
    Arch Mal Coeur Vaiss 84:227-34. 1991
  8. ncbi Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles--the role of calcineurin signaling
    Miha Trinkaus
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 175:45-9. 2008
  9. ncbi Olfactory responses of Ips duplicatus from inner Mongolia, China to nonhost leaf and bark volatiles
    Q H Zhang
    Department of Crop Science, Swedish University of Agricultural Sciences, Alnarp
    J Chem Ecol 27:995-1009. 2001
  10. ncbi Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase
    Emmanuelle Girard
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
    J Mol Neurosci 30:99-100. 2006

Detail Information

Publications156 found, 100 shown here

  1. pmc Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme
    K Ohno
    Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 95:9654-9. 1998
    ..ACHET) and heteromeric asymmetric forms composed of 1, 2, or 3 tetrameric ACHET attached to a collagenic tail (ColQ). Asymmetric AChE is concentrated at the endplate (EP), where its collagenic tail anchors it into the basal lamina...
  2. pmc Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic)
    C Donger
    INSERM U153, Group Hospitalier Pitie Salpetriere, France
    Am J Hum Genet 63:967-75. 1998
    ..which is normally concentrated at NMJs, is composed of catalytic tetramers associated with a specific collagen, COLQ. In CMS-Ic patients, these collagen-tailed forms are often absent...
  3. ncbi [Enzyme-linked immunosorbent assay using monoclonal antibodies for direct serotyping of enteric adenoviruses in feces]
    K Takagi
    Department of Microbiology, Ehime Prefectural Institute of Public Health
    Kansenshogaku Zasshi 65:552-8. 1991
    ..For identification of enteric adenoviruses (EAd) in stool specimens, enzyme-linked immunosorbent assay (ELISA) test using monoclonal antibodies was developed...
  4. ncbi Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion
    Shelley Camp
    University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
    Chem Biol Interact 157:79-86. 2005
    ..system, whereas the splice to exon 6 produces a sequence that binds to the structural subunits PRiMA and ColQ, producing AChE expression in brain and muscle...
  5. ncbi The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring
    Jean Massoulié
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Chem Biol Interact 157:3-14. 2005
    ..wide variety of oligomeric forms, ranging from monomers to heteromeric assemblies containing the anchoring proteins ColQ (collagen-tailed forms) and PRiMA (membrane-bound tetramers), which constitute the major functional enzyme species ..
  6. ncbi [Epidemiological studies on enteric adenovirus gastroenteritis in children]
    Y Yamashita
    Ehime Prefectural Institute of Public Health
    Kansenshogaku Zasshi 69:377-82. 1995
    Enteric adenoviruses (EAd), adenovirus (Ad) types 40 and 41, have been established as causative agents of gastroenteritis...
  7. ncbi Early afterdepolarizations and arrhythmogenesis. Experimental and clinical aspects
    N El-Sherif
    Cardiology Division, State University of New York Health Science Center, Brooklyn 11203
    Arch Mal Coeur Vaiss 84:227-34. 1991
    There is growing evidence that early afterdepolarizations (EADs) and EAD-induced triggered activity play a significant role in the clinical syndrome of long QTU and polymorphic ventricular tachyarrhythmias better known as Torsade de ..
  8. ncbi Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles--the role of calcineurin signaling
    Miha Trinkaus
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 175:45-9. 2008
    ..The latter is due to the absence of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
  9. ncbi Olfactory responses of Ips duplicatus from inner Mongolia, China to nonhost leaf and bark volatiles
    Q H Zhang
    Department of Crop Science, Swedish University of Agricultural Sciences, Alnarp
    J Chem Ecol 27:995-1009. 2001
    ..nonhost angiosperm trees were tested on Ips duplicatus by gas chromatographic-electroantennographic detection (GC-EAD) and by pheromone-baited traps in Sweden and Inner Mongolia, China, respectively...
  10. ncbi Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase
    Emmanuelle Girard
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
    J Mol Neurosci 30:99-100. 2006
    ..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins ColQ (Krejci et al., 1997) and PRiMA (Perrier et al., 2002)...
  11. doi Behavioral and electrophysiological responses of Triatoma brasiliensis males to volatiles produced in the metasternal glands of females
    Ana C R Vitta
    Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas, Centro de Pesquisas Rene Rachou Fiocruz, 30 190 002, Belo Horizonte, Minas Gerais, Brazil
    J Chem Ecol 35:1212-21. 2009
    ..In addition, GC-EAD recordings showed that the antennae of males responded to several of the main components of female MG secretions...
  12. pmc Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice
    N Ibnou-Zekri
    Department of Pathology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    Proc Natl Acad Sci U S A 94:14654-9. 1997
    ..that (i) the development of SLE was almost completely prevented in BXSB (H-2(b)) mice expressing two copies of the Ead transgene at the homozygous level as well as in BXSB H-2(k) (I-E+) congenic mice as for H-2(d) BXSB mice, and (ii) ..
  13. ncbi Electroantennographic and behavioral responses of the sphinx moth Manduca sexta to host plant headspace volatiles
    Ann M Fraser
    ARL Division of Neurobiology, University of Arizona, P O Box 210077, Tucson, Arizona 85721 0077, USA
    J Chem Ecol 29:1813-33. 2003
    Coupled gas chromatography with electroantennographic detection (GC-EAD) using antennae of adult female Manduca sexta was employed to screen for olfactory stimulants present in headspace collections from four species of larval host ..
  14. ncbi Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid--an exploratory study
    Frank S Rosenthal
    School of Health Sciences, Purdue University, 500 Stadium Mall Drive, West Lafayette, IN 47907, USA
    J Aerosol Med 20:83-96. 2007
    ..5/FVC), an aerosol-derived measure of pulmonary airspace size (effective airspace diameter, EAD), and an aerosol-derived measure of nonuniform ventilation (aerosol dispersion, AD)...
  15. ncbi The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat muscles
    Spela Glisović
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 187:90-5. 2010
    ..The latter is due to the nearly complete suppression of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
  16. ncbi The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers
    David Fedida
    Cardiome Pharma Corporation, University of British Columbia, Vancouver, BC, Canada
    J Cardiovasc Electrophysiol 17:S71-S78. 2006
    ..of lidocaine, mexiletine, and RSD1235 may result, at least in part, from their ability to inhibit late I(Na) during action potential repolarization, and inhibition of the inward currents contributing to EAD and arrhythmia formation.
  17. ncbi Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis
    S Sicouri
    Masonic Medical Research Laboratory, Utica, New York 13504
    J Cardiovasc Electrophysiol 4:48-58. 1993
    ..Epicardial, M region, and endocardial tissues and cells show distinct, sometimes opposite, responses to a variety of drugs, including those capable of inducing EADs and DADs...
  18. ncbi Volatile emissions from Aesculus hippocastanum induced by mining of larval stages of Cameraria ohridella influence oviposition by conspecific females
    A Bettina Johne
    Institute for Forest Zoology and Forest Conservation, Georg August University, Buesgenweg 3, 37077, Goettingen, Germany
    J Chem Ecol 32:2303-19. 2006
    ..Utilizing gas chromatography coupled with parallel detection by mass spectrometry and electroantennography (GC-MS/EAD), more than 30 compounds eliciting responses from antennae of C. ohridella were detected...
  19. ncbi Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular block
    Peter Milberg
    Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
    J Cardiovasc Pharmacol 44:278-86. 2004
    ..01), but not in amiodarone-treated hearts (10%; p = ns). Sotalol led to early afterdepolarizations (EAD) and torsade de pointes (TdP) after lowering of potassium concentration (6 of 13 hearts)...
  20. ncbi Evolution of reproductive strategies in the sexually deceptive orchid Ophrys sphegodes: how does flower-specific variation of odor signals influence reproductive success?
    M Ayasse
    Institute of Zoology, University of Vienna, Austria
    Evolution 54:1995-2006. 2000
    ..active in male olfactory receptors based on gas chromatography with electroantennographic detection (GC-EAD)...
  21. ncbi Electrophysiological and behavioral responses of Ips duplicatus to aggregation pheromone in Inner Mongolia, China: amitinol as a potential pheromone component
    Qing He Zhang
    Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, 230 53 Alnarp, Sweden
    J Chem Ecol 33:1303-15. 2007
    ..gas chromatography-mass spectrometry (GC-MS), coupled gas chromatography-electroantennographic detection (GC-EAD), and field trapping bioassays in Inner Mongolia, China...
  22. ncbi [Organ changes induced by ergot derivative dopamine agonist drugs: time to change treatment guidelines in Parkinson's disease?]
    J Roth
    Centrum extrapyramidových onemocneni, Neurologická klinika 1 LF UK a VFN, Praha
    Cas Lek Cesk 144:123-6. 2005
    ..Not to use EAD as the first-line dopamine agonists. B...
  23. ncbi Identification (GC and GC-MS) of unsaturated acetates in Elasmopalpus lignosellus and their biological activity (GC-EAD and EAG)
    Gulab N Jham
    Departamento de Quimica, Universidade Federal de Vicosa, Vicosa, MG, Brazil
    J Sep Sci 28:281-5. 2005
    ..Extract 2 was analyzed by gas chromatography (GC) and gas chromatography-electroannetography (GC-EAD) revealing the presence of (Z)-11-HDA and (Z)-9-TDA. In addition, the same compounds elicited a response with the E...
  24. ncbi The origin of the molecular diversity and functional anchoring of cholinesterases
    Jean Massoulié
    CNRS UMR 8544, Laboratoire de Neurobiologie, Ecole Normale Superieure, Paris, France
    Neurosignals 11:130-43. 2002
    ..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins, ColQ and PRiMA...
  25. ncbi [The effects of calmodulin kinase II inhibitor on ventricular arrhythmias in rabbits with cardiac hypertrophy]
    Jun Ke
    Department of Cardiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:33-6. 2007
    ..To investigate the effect of KN-93, a calmodulin kinase II inhibitor, on ventricular arrhythmias in rabbits with cardiac hypertrophy...
  26. ncbi Spontaneous, electrically, and cesium chloride induced arrhythmia and afterdepolarizations in the rapidly paced dog heart
    D L Jones
    Departments of Physiology and Medicine, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Pacing Clin Electrophysiol 24:474-85. 2001
    ..induced arrhythmia and the susceptibility of the failing dog heart to arrhythmia and early afterdepolarization (EAD) induced triggered activity elicited by exogenous administration of cesium chloride (CsCl)...
  27. ncbi Electrophysiological and behavioral responses of Ips subelongatus to semiochemicals from its hosts, non-hosts, and conspecifics in China
    Qing He Zhang
    Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, SE 230 53, Alnarp, Sweden
    J Chem Ecol 33:391-404. 2007
    ..were analyzed using both gas chromatographic-electroantennographic detection (GC-EAD) and gas chromatography/mass spectrometry (GC-MS) techniques, and field trapping bioassays in Inner Mongolia, China...
  28. doi General food semiochemicals attract omnivorous German cockroaches, Blattella germanica
    Nooshin Karimifar
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    J Agric Food Chem 59:1330-7. 2011
    ..Coupled gas chromatographic-electroantennographic detection (GC-EAD) and GC-mass spectrometric (MS) analyses of these attractive extracts, or fractions thereof, and of synthetic ..
  29. ncbi Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures
    Jeroen Kool
    LACDR Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands
    J Biomol Screen 12:396-405. 2007
    A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to ..
  30. pmc Reverse and conventional chemical ecology approaches for the development of oviposition attractants for Culex mosquitoes
    Walter S Leal
    Honorary Maeda Duffey Laboratory, Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 3:e3045. 2008
    ..both CquiOBP1 as a molecular target in binding assays and gas chromatography-electroantennographic detection (GC-EAD), we identified nonanal, trimethylamine (TMA), and skatole as test compounds...
  31. doi Aphrodisiac pheromones from the wings of the small cabbage white and large cabbage white butterflies, Pieris rapae and Pieris brassicae
    Selma Yildizhan
    Institut fur Organische Chemie, Technische Universitat Braunschweig, Hagenring 30, Braunschweig, Germany
    Chembiochem 10:1666-77. 2009
    ..activity of the compounds in the extract was tested by coupled gas chromatographic-electroantennographic (GC-EAD) analysis, which showed that both macrolides and the other major components of the wings can be detected by the ..
  32. doi Prioritizing environmental health risks in the UAE
    Henry H Willis
    RAND Corporation, Pittsburgh, PA 15213, USA
    Risk Anal 30:1842-56. 2010
    ..in the United Arab Emirates (UAE) to inform a strategic planning process led by the Environment Agency-Abu Dhabi (EAD)...
  33. pmc Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function
    G Feng
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Cell Biol 144:1349-60. 1999
    ..AChE) occurs in both asymmetric forms, covalently associated with a collagenous subunit called Q (ColQ), and globular forms that may be either soluble or membrane associated...
  34. ncbi Volatile attractants for the common bluebottle, Graphium sarpedon nipponum, from the host, Cinnamomum camphora
    Jing Li
    Department of Agriculture, Faculty of Agriculture, Kochi University, Monobe, Nankoku, Japan
    Biosci Biotechnol Biochem 74:1987-90. 2010
    ..The volatiles were analyzed by capillary gas chromatography with electro-antennographic detection (GC-EAD)...
  35. doi The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption
    Francoise Imbert-Bismut
    Department of Biochemistry, APHP Groupe Hospitalier Pitié Salpétrière, Paris, France
    Eur J Gastroenterol Hepatol 21:18-27. 2009
    The validity of biomarkers of excessive alcohol drinking (EAD) (30 g/day or more), such as carbohydrate-deficient transferrin (CDT%), is confounded by liver disease severity...
  36. doi Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexes
    Steffen Pahlich
    Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Proteome Res 8:4455-65. 2009
    ..belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD) and a C-terminal RNA-binding domain (RBD), which is extensively methylated at arginine residues...
  37. ncbi Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers
    He Li
    Eppley Institute and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Biochem J 411:425-32. 2008
    ..in the neuromuscular junctions and the central nervous system is anchored to membranes through interactions with ColQ (AChE-associated collagen tail protein) and PRiMA (proline-rich membrane anchor) proteins containing proline-rich ..
  38. ncbi Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits
    Yukiko Fukuda
    Cardiopulmonary Division of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    J Am Coll Cardiol 43:1090-100. 2004
    ..We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor...
  39. pmc Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junction
    R L Rotundo
    Department of Cell Biology and Anatomy, The University of Miami School of Medicine, 1600 N W 10th Avenue, Miami, FL 33136, USA
    Chem Biol Interact 175:26-9. 2008
    The collagen-tailed form of acetylcholinesterase (ColQ-AChE) is the major if not unique form of the enzyme associated with the neuromuscular junction (NMJ)...
  40. ncbi Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross-sectional study
    A Zutavern
    Dr von Haunersches Kinderspital University Children s Hospital, Munich, Germany
    Clin Exp Allergy 35:1301-8. 2005
    ..AD can be differentiated into an allergic extrinsic form (EAD) and a non-allergic intrinsic form (IAD)...
  41. ncbi [Distribution and risk factors of steno-occlusive lesions in patients with ischemic cerebrovascular disease]
    Dou Li
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China
    Zhonghua Yi Xue Za Zhi 88:1158-62. 2008
    ..To investigate the distribution of atherosclerotic steno-occlusive lesions in Chinese patients with ischemic cerebrovascular disease and the risk factors for occlusive lesions of intracranial and extracranial arteries...
  42. ncbi Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins
    Eugene Patterson
    University of Oklahoma Health Sciences Center and the DVA Medical Center, Oklahoma City, Oklahoma, USA
    J Am Coll Cardiol 47:1196-206. 2006
    ....
  43. ncbi Spontaneous pulmonary vein firing in man: relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitro
    Eugene Patterson
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Cardiovasc Electrophysiol 18:1067-75. 2007
    ..Rapid firing originating within pulmonary veins (PVs) initiates atrial fibrillation (AF). The following studies were performed to evaluate spontaneous PV firing in patients with AF to distinguish focal versus reentrant mechanisms...
  44. pmc Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2
    Carl Sims
    University of Pittsburgh, School of Medicine, Department of Cell Biology and Physiology, Pittsburgh, PA 15261, USA
    Circ Res 102:e86-100. 2008
    ..Therefore, sex, age, and regional differences in I(Ca,L) density and in EAD susceptibility were analyzed in epicardial left ventricular myocytes isolated from the apex and base of prepubertal ..
  45. ncbi [Effects of BmKIM on sodium current of isolated cardiomyocytes, transmembrane action potential and aconitine induced arrhythmia in vivo in rabbits]
    Teng Wang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:102-7. 2009
    ....
  46. ncbi Neuropathologic substrate of mild cognitive impairment
    William R Markesbery
    Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Arch Neurol 63:38-46. 2006
    To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD).
  47. ncbi Aerosol measurement of airspace diameter correlates with morphometry in normal and papain-exposed air dried lungs
    F S Rosenthal
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Exp Lung Res 25:425-41. 1999
    Aerosol measures of effective airspace diameter (EAD) were correlated with morphometric parameters in a series of 8 canine lungs, 5 of which had been exposed to papain in order to cause experimental emphysema...
  48. ncbi Odor composition of preferred (buffalo and ox) and nonpreferred (waterbuck) hosts of some Savanna tsetse flies
    Nicholas K Gikonyo
    International Centre of Insect Physiology and Ecology, Nairobi, Kenya
    J Chem Ecol 28:969-81. 2002
    ..octadecyl bonded) silica and analyzed with a gas chromatography-linked electroantennographic detector (GC-EAD) and, where possible, identified by using gas chromatography-linked mass spectrometry (GC-MS) and chromatographic ..
  49. ncbi Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall
    G X Yan
    Main Line Health Heart Center, Wynnewood, PA, USA
    Circulation 103:2851-6. 2001
    This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide...
  50. pmc CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during
    Frederick Y Wu
    Molecular Virology Laboratories, Department of Pharmacology and Molecular Sciences, School of dicine, The Johns Hopkins University, Baltimore, Maryland 21231 1000, USA
    J Virol 78:4847-65. 2004
    ..Finally, double-label immunofluorescence assays suggested that EAD protein expression was activated even better than ZTA expression in latently infected C/EBPalpha-transfected Akata ..
  51. doi Composition and electrophysiological activity of constituents identified in male wing gland secretion of the bumblebee parasite Aphomia sociella
    Blanka Kalinová
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, CZ 166 10 Praha 6, Czech Republic
    J Nat Prod 72:8-13. 2009
    ..gas chromatography, electroantennography (EAG), gas chromatography with electroantennographic detection (GC-EAD), and NMR...
  52. ncbi Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease
    M A Lovell
    Sanders Brown Center on Aging and Departments of Chemistry, Neurology and Pathology, University of Kentucky, Lexington, KY 40536, USA
    Neurotox Res 7:265-71. 2005
    ..levels in the HPG, SMTG and CER of 5 subjects with mild cognitive impairment (MCI), 5 subjects with early AD (EAD) and 4 appropriately age-matched controls. Western blot and dot-blot analysis showed statistically significant (p 0...
  53. ncbi Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 model
    Xiao Qing Quan
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Cardiovasc Electrophysiol 18:1184-9. 2007
    ..This study examined the effects of antiarrhythmic peptide AAP10, a gap junction enhancer, on TDR and induction of TdP in a rabbit LQT3 model...
  54. pmc Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT Conditions
    Alexander Burashnikov
    Masonic Medical Research Laboratory, Utica, NY 13501, USA
    Circ Arrhythm Electrophysiol 1:202-8. 2008
    ..The present study examines the effect of hyperthermia on transmural dispersion of action potential duration (TD-APD), early afterdepolarization (EAD) activity, and torsade de pointes (TdP) under long-QT conditions.
  55. ncbi [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]
    Huai Yu Ding
    Heart Center, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China
    Sheng Li Xue Bao 58:129-35. 2006
    ..a second plateau response could be induced easily, suggesting a strong tendency of early afterdepolarization (EAD) genesis in PVC. Non-selective cation current (I(NSCC)) was first recorded in both LAC and PVC...
  56. ncbi [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]
    Kinji Ohno
    Division of Neurogenetics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:145-51. 2009
    ..1) Defects in choline acetyltransferase reduce acetylcholine contents at the nerve terminal. (2) Collagen Q (ColQ) anchors acetylcholinesterase at the synaptic basal lamina, and its defects cause endplate acetylcholinesterase ..
  57. ncbi Training veterinary personnel for effective identification and diagnosis of exotic animal diseases
    Carmel M Kerwick
    J Vet Med Educ 35:255-61. 2008
    The requirements for exotic animal disease (EAD) training were considered at a workshop organized for those with responsibilities for EAD response management in the different states of Australia, with the objective of identifying the ..
  58. ncbi Expression and localization of acetylcholinesterase at the neuromuscular junction
    Richard L Rotundo
    Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurocytol 32:743-66. 2003
    ..large protein consists of three catalytic tetramers covalently linked to the three-stranded collagen-like tail (ColQ)...
  59. ncbi Viral vector-mediated [corrected] expression of human collagen Q in cultured cells
    Mikako Ito
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Japan
    Chem Biol Interact 175:346-8. 2008
    ..Collagen Q (ColQ) makes a triple helical structure and anchors the catalytic subunit of acetylcholinesterase (AChE) to the synaptic ..
  60. ncbi (Z,Z)-4,7-tridecadien-(S)-2-yl acetate: sex pheromone of Douglas-fir cone gall midge, Contarinia oregonensis
    Regine Gries
    Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 Canada
    J Chem Ecol 28:2283-97. 2002
    ..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of pheromone extract revealed a single compound (A) that elicited responses from male antennae...
  61. ncbi Identification of the sex pheromone of Copitarsia decolora (Lepidoptera: Noctuidae)
    Julio C Rojas
    Departamento de Entomologia Tropical, El Colegio de la Frontera Sur Apdo Postal 36, CP 30700, Tapachula, Chiapas, Mexico
    J Econ Entomol 99:797-802. 2006
    ..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analysis of the female gland extract showed the presence of two EAD-active peaks, which were identified by GC-mass ..
  62. doi Identification of host fruit volatiles from three mayhaw species (Crataegus series Aestivales) attractive to mayhaw-origin Rhagoletis pomonella flies in the southern United States
    Dong H Cha
    Department of Entomology, NYS Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    J Chem Ecol 37:961-73. 2011
    ..Coupled gas chromatography and electroantennographic detection (GC-EAD), gas chromatography with mass spectrometry (GC-MS), and flight tunnel bioassays were used to identify the ..
  63. ncbi Monitoring the endogenous steroid profile disruption in urine and blood upon nandrolone administration: An efficient and innovative strategy to screen for nandrolone abuse in entire male horses
    Z Kaabia
    LUNAM Université, ONIRIS, Laboratoire d Etude des Résidus et Contaminants dans les Aliments LABERCA, Nantes, F 44307, France Laboratoire des Courses Hippiques LCH, Verrières le Buisson, F 91370, France
    Drug Test Anal 6:376-88. 2014
    ..threshold level for nandrolone misuse is based on the urinary concentration ratio of 5α-estrane-3β,17α-diol (EAD) to 5(10)-estrene-3β,17α-diol (EED)...
  64. ncbi Experimental autoimmune diabetes: a new tool to study mechanisms and consequences of insulin-specific autoimmunity
    Tarvo Rajasalu
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Ann N Y Acad Sci 1037:208-15. 2004
    ..Based on these findings we have developed experimental autoimmune diabetes (EAD), a new mouse model characterized by (1) CD4(+)/CD8(+) insulitis, induced by (2) (prepro)insulin DNA vaccination, ..
  65. ncbi Synaptic congenital myasthenic syndrome in three patients due to a novel missense mutation (T441A) of the COLQ gene
    J S Müller
    Friedrich Baur Institute, Department of Neurology, and Gene Center, Ludwig Maximilians University, Munich, Germany
    Neuropediatrics 35:183-9. 2004
    ..endplate acetylcholinesterase (AChE) are caused by mutations in the synapse specific collagenic tail subunit gene (COLQ) of AChE...
  66. doi Acetylcholinesterase and agrin: different functions, similar expression patterns, multiple roles
    Katarina Mis
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Chem Biol Interact 203:297-301. 2013
    ..agrin is undoubtedly neural, the neural origin of AChE, which is anchored to the basal lamina with collagenic tail ColQ, is elusive...
  67. doi Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: a signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction
    Roy C Y Choi
    Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, SAR
    Chem Biol Interact 203:282-6. 2013
    The gene encoding the collagen-tailed subunit (ColQ) of acetylcholinesterase (AChE) contains two distinct promoters that drive the production of two ColQ mRNAs, ColQ-1 and ColQ-1a, in slow- and fast-twitch muscles, respectively...
  68. ncbi Junctional and extrajunctional acetylcholinesterase in skeletal muscle fibers
    Neva Crne-Finderle
    Medical Faculty, Institute of Pathophysiology, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 157:23-7. 2005
    ..molecular form, consisting of three tetrameric catalytic oligomers and three non-catalytic subunits of collagen Q (ColQ), is the functional AChE form in the neuromuscular junction...
  69. ncbi [Eosinophilic airway disorders: important causes of prolonged cough in Japan]
    Atsuko Kamachi
    Department of Respiratory Medicine, Tenshi Hospital
    Nihon Kokyuki Gakkai Zasshi 42:880-6. 2004
    ..Eosinophilic airway disorders (EAD), including atopic cough and cough variant asthma, were clinically diagnosed in 119 patients, on the basis of the ..
  70. ncbi Experimental study of the effect of autonomic nervous system on the transmural dispersion of ventricular repolarization under acute myocardial ischemia in vivo
    Cuntai Zhang
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 22:96-9. 2002
    ..MAPD90 and TDR among three myocardial layers as well as the incidence of the early afterdepolarization (EAD) before autonomic nervous stimulation and during autonomic nervous stimulation were compared...
  71. ncbi [Effects of verapamil on atrial fibrillation spontaneous initiation in the intact canine heart]
    V V Fedorov
    Kardiologiia 43:55-70. 2003
    L-type Ca(2+) current (I(Ca,L)) has been shown to play a crucial role in initiation of early after depolarization (EAD) in cardiomyocytes...
  72. ncbi Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes
    Hester M den Ruijter
    Department of Clinical and Experimental Cardiology, Experimental and Molecular Cardiology Groups, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 41:914-7. 2006
    ..Life-threatening arrhythmias in heart failure are associated with repolarization abnormalities leading to EAD(1) formation. We examined the effects of incorporated fish oil omega3-PUFAs(2) on EAD formation in pig myocytes...
  73. ncbi Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters
    Henry H C Lee
    Department of Biology, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, China
    J Biol Chem 279:27098-107. 2004
    The presence of a collagenous protein (ColQ) characterizes the collagen-tailed forms of acetylcholinesterase and butyrylcholinesterase at vertebrate neuromuscular junctions which is tethered in the synaptic basal lamina...
  74. doi Apple volatiles synergize the response of codling moth to pear ester
    Ashraf M El-Sayed
    The New Zealand Institute for Plant and Food Research Limited, Gerald Street, Lincoln 7608, New Zealand
    J Chem Ecol 39:643-52. 2013
    ..Using gas chromatography-electroantennogram detector (GC/EAD) analysis, six compounds elicited responses from antennae of females...
  75. ncbi Elements of the C-terminal t peptide of acetylcholinesterase that determine amphiphilicity, homomeric and heteromeric associations, secretion and degradation
    Stéphanie Belbeoc'h
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Eur J Biochem 271:1476-87. 2004
    ..of homo-oligomers (monomers, dimers and tetramers) and heteromeric associations with the anchoring proteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD)...
  76. doi Prediction of early allograft dysfunction using serum phosphorus level in living donor liver transplantation
    Sang Hyun Hong
    Department of Anaesthesiology and Pain Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Transpl Int 26:402-10. 2013
    ..We investigated the predictive role of serum phosphorus for early allograft dysfunction (EAD) after living donor liver transplantation (LDLT)...
  77. doi Populations of the gall midge Dasineura oxycoccana on cranberry and blueberry produce and respond to different sex pheromones
    Sheila M Fitzpatrick
    Agriculture and Agri Food Canada, Pacific Agri Food Research Centre, P O Box 1000, Agassiz, BC, V0M 1A0, Canada
    J Chem Ecol 39:37-49. 2013
    ..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of pheromone gland extract from the ovipositor of calling CTW females revealed one component (<10 pg ..
  78. pmc Imaging arrhythmogenic calcium signaling in intact hearts
    Peng Sheng Chen
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, 1800 N Capitol Ave, E475, Indianapolis, IN 46202, USA
    Pediatr Cardiol 33:968-74. 2012
    ..Phase 3 EAD is dependent on heterogeneously prolonged action potential duration (APD)...
  79. pmc Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT?
    A Sinha
    Polyposis Registry, St Mark s Hospital, Harrow, UK
    Br J Radiol 85:e254-61. 2012
    ..We aimed to determine whether MRI provides equivalent or better assessment of desmoid tumours than CT, the current first-line investigation...
  80. pmc Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits
    Gong Xin Liu
    Cardiovascular Research Centre, Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Physiol 590:1171-80. 2012
    Early after-depolarization (EAD), or abnormal depolarization during the plateau phase of action potentials, is a hallmark of long-QT syndrome (LQTS)...
  81. doi Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation
    Jin Bae Kim
    The Division of Cardiology, Kyung Hee University College of Medicine, 1 Hoegi dong, Dongdaemun Gu, Seoul, Republic of Korea
    Toxicol Appl Pharmacol 259:66-73. 2012
    ..Spontaneous early afterdepolarization (EAD) and ventricular tachycardia (VT) were observed in 8 (67%) and 6 (50%) hearts, respectively, versus no spontaneous ..
  82. ncbi [Congenital myasthenic syndromes]
    Kinji Ohno
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
    Rinsho Shinkeigaku 52:1159-61. 2012
    ..Third, collagen Q (ColQ) anchors acetylcholinesterase (AChE) to the synaptic basal lamina and mutations in COLQ lead to endplate AChE ..
  83. ncbi Advances and perspectives in mental health: is psychiatry being stigmatized?
    R Montenegro
    Corporate Secretary of the World Federation for Mental Health, Former President of the Latin American Psychiatric Association, Former President of the Association of Argentinean Psychiatrists
    Psychiatriki 22:283-9. 2011
    ..In order to achieve the best results we should avoid militant attitudes and the ideologization of reality, and be as creative as possible looking for the best way to do so...
  84. doi Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase
    Dong Liang
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, Paris, France
    FEBS J 276:94-108. 2009
    ..This t peptide allows their assembly into tetramers associated with the anchoring proteins ColQ and PRiMA...
  85. ncbi Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain
    K K Li
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China
    J Biol Chem 275:23053-8. 2000
    The Ewing's sarcoma (EWS) oncogene contains an N-terminal transcriptional activation domain (EWS activation domain, EAD) and a C-terminal RNA-binding domain (RBD)...
  86. pmc Arrhythmogenesis by single ectopic beats originating in the Purkinje system
    Makarand Deo
    Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA
    Am J Physiol Heart Circ Physiol 299:H1002-11. 2010
    ..of tissue conductivity and excitability, as well as interaction with sinus excitation, in determining whether an EAD-induced ectopic beat will establish reentrant activity...
  87. doi Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers
    Alberto Corrias
    Computing Laboratory, University of Oxford, Oxford, UK
    Am J Physiol Heart Circ Physiol 300:H1806-13. 2011
    ..Repolarization abnormalities such as action potential (AP) prolongation and early afterdeploarizations (EAD) are often observed in vitro upon pharmacological interventions...
  88. ncbi [Generics of antiepileptic drugs]
    M Maeder-Ingvar
    Unité d épileptologie, Service de Neurologie, Departement des neurosciences cliniques, CHUV, 01011 Lausanne
    Rev Med Suisse 6:907-9. 2010
    Generic substitution of antiepileptic drugs (EAD) have limited use because epilepsy is a chronic disease, seizure recurrence has an important impact of the quality of life and the potential risk of accidents...
  89. doi Conductive indium-tin oxide nanowire and nanotube arrays made by electrochemically assisted deposition in template membranes: switching between wire and tube growth modes by surface chemical modification of the template
    Nina I Kovtyukhova
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nanoscale 3:1541-52. 2011
    ..from acidic aqueous solutions of inorganic precursors in a simple one-step electrochemically assisted deposition (EAD) process inside Au-plugged anodic aluminium oxide and polycarbonate membranes...
  90. ncbi Formate analogs as antagonists of the sex pheromone of the honeydew moth, Cryptoblabes gnidiella: electrophysiological, behavioral and field evidence
    Carolina Sellanes
    Laboratorio de Ecología Química, Facultad de Quimica, Universidad de la Republica, Gral Flores 2124, CP 11800 Montevideo, Uruguay
    J Chem Ecol 36:1234-40. 2010
    ..In gas chromatography-electroantennogram detection (GC-EAD) studies, both analogs elicited responses from C. gnidiella male antennae...
  91. doi Congenital myasthenic syndromes in childhood: diagnostic and management challenges
    M Kinali
    The Dubowitz Neuromuscular Centre, Great Ormond Street Hospital and Institute of Child Health, University College, London, UK
    J Neuroimmunol 201:6-12. 2008
    ..A repetitive CMAP was detected in only one of seven children with a COLQ mutation and neither of the two children with Slow Channel Syndrome mutations...
  92. pmc The ZIIR element of the Epstein-Barr virus BZLF1 promoter plays a central role in establishment and maintenance of viral latency
    Xianming Yu
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706 1599, USA
    J Virol 85:5081-90. 2011
    ..cells infected with ZIIR mutant (ZIIRmt) virus produced at least 20-fold more viral IE Zta and Rta and early (E) EAD protein than did cells infected with the parental wild-type (WT) virus, leading to viral DNA replication and ..
  93. ncbi Disease control options for emergency animal diseases--necessary yet sensitive elimination of disease
    Richard Rubira
    Australian Government Department of Agriculture, Fisheries and Forestry, GPO Box 858, Canberra, ACT 2601, Australia
    Vet Ital 43:333-48. 2007
    In the event of any emergency animal disease (EAD) outbreak, the overall aim should be the swift containment and subsequent elimination of the causal agent, whilst maintaining optimal welfare of the affected animal population and ..
  94. pmc Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers
    David S Auerbach
    Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48108, USA
    J Physiol 589:2363-81. 2011
    ..5 protein expression, peak and persistent INa density, A Pupstroke velocity, AP duration, conduction velocity and EAD incidence, as well as reflection incidence (29.2%, n =48 vs. uninfected, 9.4%, n =64; and Ad-GFP, 4.8%, n =21)...
  95. pmc Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening
    Jonas M Bengtsson
    Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden
    J Chem Ecol 35:1063-76. 2009
    ..Webb (Malvaceae) for antennal activity using gas chromatograph-coupled electroantennographic detection (GC-EAD). Compounds active in GC-EAD were identified by combined gas chromatography and mass spectrometry (GC-MS)...
  96. doi Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium
    Yung Kuo Lin
    Division of Cardiovascular Medicine, Taipei Medical University, Wan Fang Hospital, Taiwan
    Clin Sci (Lond) 122:121-32. 2012
    ..8±0.1 to 1.3±0.2 and 0.8±0.1 Hz at 30 and 60 min respectively (n=8, P<0.005), and induced EAD (early after depolarization) in three (37.5%) of the PVs and DAD (delayed after depolarization) in one (12...
  97. pmc Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation
    Vicky P Chen
    Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology Hong Kong, China
    Front Mol Neurosci 4:36. 2011
    ..of AChE T variant are depending primarily on the association of their anchoring partners, either collagen tail (ColQ) or proline-rich membrane anchor (PRiMA)...
  98. doi Synthetic grape volatiles attract mated Lobesia botrana females in laboratory and field bioassays
    Gianfranco Anfora
    IASMA FEM Research and Innovation Centre, San Michele a A, TN, Italy
    J Chem Ecol 35:1054-62. 2009
    ..The six major components of the odor profiles that were GC-EAD-active to female antennae included: limonene, 4,8-dimethyl-1,(E)-3,7-nonatriene, (+/-)-linalool, (E)-caryophyllene, ..
  99. ncbi Enhanced repolarization capacity: new potential antiarrhythmic strategy based on HERG channel activation
    G Szabo
    Department of Physiology, University of Debrecen, Nagyerdei Krt 98 H 4012 Debrecen, Hungary
    Curr Med Chem 18:3607-21. 2011
    ..either by a pathological factor or due to a pharmacological intervention - threatens with an increased risk of EAD generation and the concomitant sudden cardiac death...
  100. doi Comparative GC-EAD responses of a specialist (Microplitis croceipes) and a generalist (Cotesia marginiventris) parasitoid to cotton volatiles induced by two caterpillar species
    Esther Ngumbi
    Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, USA
    J Chem Ecol 35:1009-20. 2009
    ..and Spodoptera spp. We compared GC-EAD (coupled gas chromatography electroantennogram detection) responses of both parasitoid species to headspace ..
  101. ncbi Identification by GC-EAD of the two-component trail-following pheromone of Prorhinotermes simplex (Isoptera, Rhinotermitidae, Prorhinotermitinae)
    David Sillam-Dussès
    Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Praha, Czech Republic
    J Insect Physiol 55:751-7. 2009
    ..simplex, P. canalifrons, P. inopinatus). In addition, EAG and GC-EAD experiments with P...

Research Grants99

  1. Congenital Myasthenic Syndromes: Pathogenic Mechanisms
    RICARDO ANIBAL MASELLI; Fiscal Year: 2010
    ..receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
  2. Congenital Myasthenic Syndromes: Pathogenic Mechanisms
    RICARDO ANIBAL MASELLI; Fiscal Year: 2013
    ..receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
  3. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2010
    ..Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (DAD), and triggered activity (TA), and has been suggested as a potential ..
  4. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (DAD), and triggered activity (TA), and has been suggested as a potential ..
  5. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (DAD), and triggered activity (TA), and has been suggested as a potential ..
  6. Role of the Bradykinin Pathway in Craniofacial Development
    LAURA ANNE JACOX; Fiscal Year: 2012
    ..The mouth develops from the "extreme anterior domain" (EAD), where the ectoderm and endoderm directly juxtapose...
  7. Role of the Bradykinin Pathway in Craniofacial Development
    LAURA ANNE JACOX; Fiscal Year: 2013
    ..The mouth develops from the "extreme anterior domain" (EAD), where the ectoderm and endoderm directly juxtapose...
  8. Mechanisms of cardiac Ca dysregulation and arrhythmias in ankyrin B deficiency
    Sanda Despa; Fiscal Year: 2013
    ..larger cellular and sarcoplasmic reticulum (SR) Ca load and increased frequency of early afterdepolarizations (EAD) and delayed afterdepolarizations (DAD)...
  9. The role of dynamic changes in repolarization and calcium transients in Long QT r
    Bum Rak Choi; Fiscal Year: 2010
    ..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
  10. The role of dynamic changes in repolarization and calcium transients in Long QT r
    Bum Rak Choi; Fiscal Year: 2013
    ..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
  11. Ca & InsP3 Receptor Signaling in Cardiac Myocytes
    LOTHAR BLATTER; Fiscal Year: 2009
    ..SR Ca overload, Ca waves, Ca alternans, enhanced Ca spark frequency) and changes of membrane potential (early (EAD) and delayed (DAD) afterdepolarizations, spontaneous action potentials (APs) and electrical alternans) in Hyp/HF ..
  12. Post-transcriptional regulation of synaptic acetylcholinesterase in muscle
    Carlos Ruiz; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Synaptic acetylcholinesterase (ColQ-AChE) is localized at the neuromuscular junctions in skeletal muscle...
  13. Fibrillation and Defibrillation
    Peng Sheng Chen; Fiscal Year: 2010
    ..Our preliminary studies showed that late phase 3 EAD may also play a role in postshock arrhythmias in failing and ischemic hearts...
  14. A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the Organ
    Gideon Koren; Fiscal Year: 2013
    ..tissue heterogeneities mediate the R-on-T phenomenon as well as test whether short-long-short sequence increases EAD formations and tissue heterogeneities, thus self propels until the onset of TdP and weather TdP and PVT are ..
  15. ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELS
    David J Mooney; Fiscal Year: 2010
    ..The successful completion of these aims will ead to new strategies for the regeneration of functional muscle tissue...
  16. Modeling of Cardiac Calcium Dynamics;Ryanodine Receptor induced Arrhythmias
    Daisuke Sato; Fiscal Year: 2013
    ..2) how an EAD or DAD from a single cell can cause a group of cells to simultaneously generate EADs or DADs to exceed the critical ..
  17. The role of dynamic changes in repolarization and calcium transients in Long QT r
    Bum Rak Choi; Fiscal Year: 2009
    ..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
  18. ROLE OF PROLONGED REPOLARIZATION IN CARDIAC ARRHYTHMIAS
    Dan Roden; Fiscal Year: 1990
    ..One of the most important findings to date is that ventricular muscle blunts the action potential prolongation and EAD induction by quinidine in Purkinje tissue...
  19. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2000
    ..perfused heart using the characteristics of the action potential (AP), QT interval and early after depolarization (EAD) occurrence...
  20. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 1999
    ..perfused heart using the characteristics of the action potential (AP), QT interval and early after depolarization (EAD) occurrence...
  21. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2001
    ..perfused heart using the characteristics of the action potential (AP), QT interval and early after depolarization (EAD) occurrence...
  22. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    ..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
  23. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    C Pauza; Fiscal Year: 2006
    ..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
  24. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    ..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
  25. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2009
    ..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
  26. Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell death
    CHARLES PAUZA; Fiscal Year: 2007
    ..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
  27. Adolescent Controlled Text Messaging to Improve Asthma Medication Adherence in Pr
    Maria T Britto; Fiscal Year: 2013
    ..Through this research, we will gather data on feasibility, usability and efficacy of the intervention that will ead to a future R01 application to examine the intervention's efficacy in a fully powered randomized trial.
  28. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2006
    ..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
  29. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2007
    ..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
  30. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2005
    ..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
  31. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2007
    ..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
  32. THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASE
    Donald Leung; Fiscal Year: 2009
    ..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
  33. The Role of bacterial toxins in human skin disease.
    Donald Leung; Fiscal Year: 2006
    ..aureus. We hypothesize that increased IL-4/IL-13 in the skin of extrinsic AD (EAD) patients inhibits the capacity of keratinocytes to phagocytosize and kill S. aureus in EAD...
  34. Fibrillation and Defibrillation
    Peng Sheng Chen; Fiscal Year: 2009
    ..Our preliminary studies showed that late phase 3 EAD may also play a role in postshock arrhythmias in failing and ischemic hearts...
  35. EFFECTS OF MORPHINE AND GENOTOXICANTS ON LYMPHOCYTES
    DAVID COUCH; Fiscal Year: 1991
    ..immunodeficiency viruses (HIV) and abuse of narcotic analgesics produce decreased immune responsiveness which could ead to the ensuing health sequela...
  36. H-Tunneling in Methylmalonyl-CoA Mutase
    Ruma Banerjee; Fiscal Year: 2004
    ..values for the ratio of the Arrhenius preexponential factors (AH/AD) and for the difference in activation energies (EaD-EaH) that lie well outside the semiclassical range...
  37. H-Tunneling in Methylmalonyl-CoA Mutase
    Ruma Banerjee; Fiscal Year: 2002
    ..values for the ratio of the Arrhenius preexponential factors (AH/AD) and for the difference in activation energies (EaD-EaH) that lie well outside the semiclassical range...
  38. H-Tunneling in Methylmalonyl-CoA Mutase
    Ruma Banerjee; Fiscal Year: 2003
    ..values for the ratio of the Arrhenius preexponential factors (AH/AD) and for the difference in activation energies (EaD-EaH) that lie well outside the semiclassical range...
  39. CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2005
    ..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
  40. CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2006
    ..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
  41. CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2007
    ..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
  42. CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2004
    ..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
  43. CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONS
    Mark Anderson; Fiscal Year: 2003
    ..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
  44. ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELS
    David Mooney; Fiscal Year: 2009
    ..The successful completion of these aims will ead to new strategies for the regeneration of functional muscle tissue...
  45. ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELS
    David Mooney; Fiscal Year: 2007
    ..The successful completion of these aims will ead to new strategies for the regeneration of functional muscle tissue...
  46. MODULATION OF CLASS III ANTIARRHYTHMIC DRUG EFFECTS
    Michael Sanguinetti; Fiscal Year: 1999
    ..drugs; 3) to map the binding site on HERG channels for methanesulfonanilides; 4) to determine the mechanism of EAD suppression by an increase in (Mg2+]e in myocytes exposed to selective class III antiarrhythmic drugs; and 5) to ..
  47. MODULATION OF CLASS III ANTIARRHYTHMIC DRUG EFFECTS
    Michael Sanguinetti; Fiscal Year: 2000
    ..drugs; 3) to map the binding site on HERG channels for methanesulfonanilides; 4) to determine the mechanism of EAD suppression by an increase in (Mg2+]e in myocytes exposed to selective class III antiarrhythmic drugs; and 5) to ..
  48. EARLY AFTER DEPOLARIZATIONS--MECHANISM/ROLE OF CALCIUM
    Craig January; Fiscal Year: 1990
    ..in voltage clamped and non-voltage clamped Purkinje strands with this model have permitted us to hypothesize that EAD induction 1 requires: 1) Lengthening and flattening of the action potential plateau within a voltage range where, 2)..
  49. EARLY AFTER DEPOLARIZATIONS--MECHANISM/ROLE OF CALCIUM
    Craig January; Fiscal Year: 1993
    ..in voltage clamped and non-voltage clamped Purkinje strands with this model have permitted us to hypothesize that EAD induction 1 requires: 1) Lengthening and flattening of the action potential plateau within a voltage range where, 2)..
  50. CARDIOPLEGIA AND CORONARY MICROVASCULAR REACTIVITY
    Frank Sellke; Fiscal Year: 2009
    ..and CPB, a better understandingi of thei regulationi of the (Mronarymicrovasculature of these patients may ead to improved outcomes after cardiac surgery...
  51. Age-related decline in sleep-dependent memory consolidation
    Rebecca M C Spencer; Fiscal Year: 2010
    ..These results ead to a number of questions which will be examined in the proposed research...
  52. Age-related decline in sleep-dependent memory consolidation
    Rebecca Spencer; Fiscal Year: 2009
    ..These results ead to a number of questions which will be examined in the proposed research...
  53. Fax to Quit: Linking Smokers Visiting Clinics to State Quitlines
    Michael Fiore; Fiscal Year: 2009
    ..evaluate two forms of Fax to Quit: Fax to Quit alone (FQ) and Fax to Quit plus Enhanced Academic Detailing (FQ + EAD) with EAD comprising ongoing training/technical assistance and performance feedback...
  54. Fax to Quit: Linking Smokers Visiting Clinics to State Quitlines
    Michael Fiore; Fiscal Year: 2007
    ..evaluate two forms of Fax to Quit: Fax to Quit alone (FQ) and Fax to Quit plus Enhanced Academic Detailing (FQ + EAD) with EAD comprising ongoing training/technical assistance and performance feedback...
  55. Ca & InsP3 Receptor Signaling in Cardiac Myocytes
    LOTHAR BLATTER; Fiscal Year: 2006
    ..SR Ca overload, Ca waves, Ca alternans, enhanced Ca spark frequency) and changes of membrane potential (early (EAD) and delayed (DAD) afterdepolarizations, spontaneous action potentials (APs) and electrical alternans) in Hyp/HF ..
  56. ELECTRON MICROSCOPY OF MYOPATHIES
    Andrew Engel; Fiscal Year: 1980
    ..In carnitine deficiency cultured muscle cells will be studied for a postulated abnormality of carnitine transport. The biochemical basis of an adult onset polyglucosan storage disease will be investigated...
  57. CONGENITAL MYASTHENIC SYNDROMES
    Andrew Engel; Fiscal Year: 2009
    ..They frequently go undiagnosed or misdiagnosed yet their consequences are often highly disabling. The CMS will be studied by a multifaceted approach that will improve their diagnosis, treatment, and prevention. ..
  58. ELECTRON MICROSCOPY OF MYOPATHIES
    Andrew Engel; Fiscal Year: 1990
    ..In dermatomyositis the hypothesis will be tested that the pathologic features of the disease are mediated by a circulating autoantibody...
  59. ELECTRON MICROSCOPY OF MYOPATHIES
    Andrew Engel; Fiscal Year: 1993
    ..In the newly discovered mitochondrial encephalomyopathy due to coenzyme Q10 deficiency, the hypothesis will be tested that the disorder is caused by a defect in the mitochondrial biosynthesis of coenzyme Q10...
  60. CONGENITAL MYASTHENIC SYNDROMES
    Andrew Engel; Fiscal Year: 2002
    ..abstract_text> ..
  61. CONGENITAL MYASTHENIC SYNDROMES
    Andrew Engel; Fiscal Year: 2001
    ..Moreover, recognition of spontaneous mutations in the EP nicotinic AChR should spur the search for mutations in neuronal nicotinic AChRs and other ligand-gated channels in various neurologic and psychiatric disorders. ..
  62. Occupational Safety and Health Traning Grant
    FRANK ROSENTHAL; Fiscal Year: 2008
    ..S. workplaces. These professionals assess hazards, investigate the causes and contributing factors of these hazards, and design methods of reducing safety and health risks. ..
  63. Multidisciplinary Study of Social Behavior and Emotion in Frontotemporal Dementia
    Mario Mendez; Fiscal Year: 2009
    ..This application combines many specialists to study disturbed social behavior in frontotemporal dementia. The results of the project can clarify how social behavior is altered by mental disorders or brain diseases. ..
  64. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2001
    ..These studies will help better understand how nerves control muscle function at the molecular level, and what happens to muscle when it loses the regulatory influence of the nerves. ..
  65. PREVENTION OF ALZHEIMER'S BY VITAMIN E AND SELENIUM
    William Markesbery; Fiscal Year: 2006
    ..In addition, it will evaluate the effect of antioxidant therapy in a group of 200 elderly longitudinally followed normal controls. ..
  66. DISRUPTION OF ZINC HOMEOSTASIS IN ALZHEIMER'S DISEASE
    Mark Lovell; Fiscal Year: 2000
    ....
  67. Liver Regeneration in the Transplant Setting
    KIM MARIE OLTHOFF; Fiscal Year: 2010
    ..Understanding the mechanistic biology of graft recovery and pathways of liver regeneration will provide important data for designing treatment modalities that will prevent injury and enhance recovery and regeneration. ..
  68. DISRUPTION OF ZINC HOMEOSTASIS IN ALZHEIMER'S DISEASE
    Mark Lovell; Fiscal Year: 2002
    ....
  69. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2005
    ..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
  70. TRAUMATIC BRAIN INJURY AND CELLULAR HOMEOSTASIS
    Stephen Scheff; Fiscal Year: 2003
    ..These studies will significantly enhance our understanding of the mechanisms following TBI and hopefully lead to therapies resulting in increased recovery. ..
  71. DETERMINANTS OF CARDIAC REPOLARIZATION
    Craig January; Fiscal Year: 2002
    ..Elucidating mechanisms in these areas in important in developing new strategies for understanding normal and abnormal arrhythmogenesis and for new strategies for anti-arrhythmic therapies. ..
  72. DETERMINANTS OF CARDIAC REPOLARIZATION
    Craig January; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  73. RESPONSE OF THE AGING NERVOUS SYSTEM TO TRAUMA
    Stephen Scheff; Fiscal Year: 2004
    ..Specific aim #4 will use a 'creatine-supplemented' dietary intervention that enhances cytosolic phosphocreatine and increases the ability of neurons to produce ATP, an intervention to reverse the age-related response to TBI. ..
  74. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2005
    ..2) We will study the regulation of assembly of the synaptic ColQ AChE form consisting of three tetramers attached to the collagenic tail and the role of transcriptional and post-..
  75. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS/ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 1990
    ..And 5) To begin long range studies on the signaling mechanisms involved in regulating gene expression in electrically excitable cells using AChE as as model system...
  76. NERVE SPROUTING AND ELECTRICAL REMODELING
    Peng Sheng Chen; Fiscal Year: 2000
    ..These studies may lead to novel insights into the mechanisms of ventricular arrhythmogenesis after MI and may help develop new methods for arrhythmia control. ..
  77. TRAUMATIC BRAIN INJURY AND CELLULAR HOMEOSTASIS
    Stephen Scheff; Fiscal Year: 2000
    ..These studies will significantly enhance our understanding of the mechanisms following TBI and hopefully lead to therapies resulting in increased recovery. ..
  78. SYNAPTIC CHANGE IN MILD COGNITIVE IMPAIRMENT
    Stephen Scheff; Fiscal Year: 2008
    ..Successful completion of the proposed studies will lead to new insights into the mechanisms underlying MCI and early AD and contribute to the development of effective pharmacologic therapies for AD. ..
  79. REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLY
    RICHARD ROTUNDO; Fiscal Year: 2009
    ..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
  80. Autonomic Nerve Activity and Paroxysmal Atrial Fibrillation
    Peng Sheng Chen; Fiscal Year: 2009
    ..The results will be used to test the hypothesis simultaneous norepinephrine and acetylcholine stimulation in canine PV in vitro promotes triggered activity through Ca transient triggering mechanisms. ..