cocaine and amphetamine regulated transcript


Gene Symbol: cocaine and amphetamine regulated transcript
Description: CART prepropeptide
Alias: CART, cocaine- and amphetamine-regulated transcript protein
Species: human

Top Publications

  1. Fu M, Cheng H, Chen L, Wu B, Cai M, Xie D, et al. [Association of the cocaine and amphetamine-regulated transcript gene with type 2 diabetes mellitus]. Zhonghua Nei Ke Za Zhi. 2002;41:805-8 pubmed
    To investigate whether genetic variation in cocaine and amphetamine-regulated transcript (CART) gene might contribute to the genesis of type 2 diabetes...
  2. Kristensen P, Judge M, Thim L, Ribel U, Christjansen K, Wulff B, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998;393:72-6 pubmed
    ..Here we show that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely ..
  3. Challis B, Yeo G, Farooqi I, Luan J, Aminian S, Halsall D, et al. The CART gene and human obesity: mutational analysis and population genetics. Diabetes. 2000;49:872-5 pubmed
    The cocaine- and amphetamine-regulated transcript (CART) peptide is a recently characterized neuropeptide implicated in the control of appetite. We hypothesized that genetic variation in CART may contribute to human obesity...
  4. del Giudice E, Santoro N, Cirillo G, D Urso L, Di Toro R, Perrone L. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes. 2001;50:2157-60 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) inhibits feeding and induces the expression of c-Fos in hypothalamic areas implicated in appetite regulation...
  5. Yamada K, Yuan X, Otabe S, Koyanagi A, Koyama W, Makita Z. Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity. Int J Obes Relat Metab Disord. 2002;26:132-6 pubmed
    We tested the hypothesis that polymorphisms in the cocaine- and amphetamine-regulated-transcript (CART) gene is associated with the development of obesity. Five-hundred and twenty-eight subjects (325 men and 203 women) aged 49.6+/-11...
  6. Menyhért J, Wittmann G, Lechan R, Keller E, Liposits Z, Fekete C. Cocaine- and amphetamine-regulated transcript (CART) is colocalized with the orexigenic neuropeptide Y and agouti-related protein and absent from the anorexigenic alpha-melanocyte-stimulating hormone neurons in the infundibular nucleus of the human h. Endocrinology. 2007;148:4276-81 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered anorexigenic peptide...
  7. Ludvigsen S, Thim L, Blom A, Wulff B. Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold. Biochemistry. 2001;40:9082-8 pubmed
    b>Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and ..
  8. Mao P, Ardeshiri A, Jacks R, Yang S, Hurn P, Alkayed N. Mitochondrial mechanism of neuroprotection by CART. Eur J Neurosci. 2007;26:624-32 pubmed
    We previously demonstrated that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) is protective against focal cerebral ischemia in vivo and against neuronal cell death in culture induced by oxygen-glucose deprivation (..
  9. Schultz K, Wiehager S, Nilsson K, Nielsen J, Lindquist S, Hjermind L, et al. Reduced CSF CART in dementia with Lewy bodies. Neurosci Lett. 2009;453:104-6 pubmed publisher
    ..b>Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus...

More Information

Publications122 found, 100 shown here

  1. Goebel Stengel M, Wang L. Central and peripheral expression and distribution of NUCB2/nesfatin-1. Curr Pharm Des. 2013;19:6935-40 pubmed
    ..Anatomical data suggest that nesfatin-1 is a unique neuroendocrine peptide that may be involved in regulation of homeostasis. ..
  2. Bigio B, Mathe A, Sousa V, Zelli D, Svenningsson P, McEwen B, et al. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proc Natl Acad Sci U S A. 2016;113:7906-11 pubmed publisher
    ..The approach here serves as a model for identifying markers and underlying mechanisms of predisposition to diseases and treatment responsiveness that may be useful in translation to human behavior and psychopathology. ..
  3. Lima G, Vuolo M, Batista A, Dragano N, Solon C, Maróstica Júnior M. Passiflora edulis peel intake improves insulin sensitivity, increasing incretins and hypothalamic satietogenic neuropeptide in rats on a high-fat diet. Nutrition. 2016;32:863-70 pubmed publisher
    ..The PEPF intake increased the hypothalamic cocaine- and amphetamine-regulated transcript expression (CART) (P < 0.05), counteracted cumulative body weight gain (P < 0.001), decreased adiposity (P < 0...
  4. Tinkov A, Ajsuvakova O, Skalnaya M, Skalny A, Aschner M, Suliburska J, et al. Organotins in obesity and associated metabolic disturbances. J Inorg Biochem. 2018;191:49-59 pubmed publisher parallel with of pro-opiomelanocortin (POMC), Agouti-related protein (AgRP), and cocaine and amphetamine regulated transcript (CART) down-regulation in the arcuate nucleus...
  5. Ma S, Ge Y, Gai X, Xue M, Li N, Kang J, et al. Transgenic n-3 PUFAs enrichment leads to weight loss via modulating neuropeptides in hypothalamus. Neurosci Lett. 2016;611:28-32 pubmed publisher
    ..Neuropeptide Y (NPY), Agouti-related peptides (AgRP), Proopiomelanocortin (POMC), Cocaine and amphetamine regulated transcript (CART), ghrelin and nesfatin-1 in hypothalamus by real-time PCR...
  6. Duan K, Yu W, Lin Z, Tan S, Bai X, Gao T, et al. Endotoxemia-induced muscle wasting is associated with the change of hypothalamic neuropeptides in rats. Neuropeptides. 2014;48:379-86 pubmed publisher
    ..Hypothalamic neuropeptides, proopiomelanocortin (POMC), cocaine- and amphetamine-regulated transcript (CART), agouti-related protein (AgRP) and neuropeptide Y (NPY) presented a dynamic change after LPS injection...
  7. Calarco C, Lee S, Picciotto M. Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice. Neuropharmacology. 2017;123:210-220 pubmed publisher
    ..These data demonstrate that chronic consumption of nicotine moderates the effect of HFD in male mice by changing metabolism rather than food intake, and identify a differential effect on female mice. ..
  8. Schlenker E. Sexual dimorphism of cardiopulmonary regulation in the arcuate nucleus of the hypothalamus. Respir Physiol Neurobiol. 2017;245:37-44 pubmed publisher
    ..Results highlight the significance of the ANH in cardiopulmonary regulation. The paucity of studies in this area that will hopefully spark investigations of sexually dimorphic ANH-modulation of breathing. ..
  9. Kursungoz C, Ak M, Yanik T. Effects of risperidone treatment on the expression of hypothalamic neuropeptide in appetite regulation in Wistar rats. Brain Res. 2015;1596:146-55 pubmed publisher appetite regulation; neuropeptide Y (NPY); alpha melanocyte stimulating hormone (α-MSH); cocaine and amphetamine regulated transcript (CART); agouti-related peptide (AgRP); and leptin in male Wistar rats, which were treated with ..
  10. Zhang J, Zhao X, Wen J, Tan S, Zhao Z. Plasticity in gastrointestinal morphology and enzyme activity in lactating striped hamsters (Cricetulus barabensis). J Exp Biol. 2016;219:1327-36 pubmed publisher
    ..and the anorexigenic neuropeptides pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) did not differ among females raising small, medium and large litters...
  11. Tuziak S, Rise M, Volkoff H. An investigation of appetite-related peptide transcript expression in Atlantic cod (Gadus morhua) brain following a Camelina sativa meal-supplemented feeding trial. Gene. 2014;550:253-63 pubmed publisher
    ..pmch), hypocretin (synonym: orexin, hcrt), neuropeptide Y (npy) and cocaine- and amphetamine-regulated transcript (cart)] was assessed using quantitative real-time PCR in brain regions related to food intake regulation (telencephalon/..
  12. Gasparini S, Resch J, Narayan S, Peltekian L, Iverson G, Karthik S, et al. Aldosterone-sensitive HSD2 neurons in mice. Brain Struct Funct. 2019;224:387-417 pubmed publisher
    ..This projection pattern raises the possibility that a subset of HSD2 neurons promotes the dysphoric, anorexic, and anhedonic symptoms of hyperaldosteronism via AgRP-inhibited relay neurons in PB. ..
  13. Makowska K, Gonkowski S. Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon. Int J Mol Sci. 2019;20: pubmed publisher
    ..This may suggest that the distribution and exact role of this substance in the ENS depend on the sex hormones. ..
  14. Dimitri P, Rosen C. The Central Nervous System and Bone Metabolism: An Evolving Story. Calcif Tissue Int. 2017;100:476-485 pubmed publisher
    ..including neuropeptide Y (NPY), serotonin, endocannabinoids, cocaine- and amphetamine-regulated transcript (CART), adiponectin, melatonin and neuromedin U, controlling osteoblast and osteoclast differentiation, proliferation and ..
  15. Persson Augner D, Lee Y, Tovar S, Dieguez C, Meister B. Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA. Neuroendocrinology. 2014;100:209-20 pubmed publisher
    ..Presence of DLK1 in the majority of orexigenic Arc NPY/AgRP neurons and regulation of DLK1 mRNA by nutritional challenge suggest that DLK1 has a role in hypothalamic regulation of body weight control. © 2014 S. Karger AG, Basel. ..
  16. Gong N, Jönsson E, Björnsson B. Acute anorexigenic action of leptin in rainbow trout is mediated by the hypothalamic Pi3k pathway. J Mol Endocrinol. 2016;56:227-38 pubmed publisher
    ..low dose, Lep stimulates hypothalamic transcription of anorexigenic cocaine- and amphetamine-regulated transcript (Cart) and orexigenic neuropeptide Y...
  17. Wang J, Yi J, Siegel P, Cline M, Gilbert E. Stress-induced suppression of neuropeptide Y-induced hunger in anorexic chicks involves corticotrophin-releasing factor signalling and the paraventricular nucleus of the hypothalamus. J Neuroendocrinol. 2017;29: pubmed publisher
    ..The results of the present study provide insights into the molecular basis of eating disorders and suggest that CRF signalling in the PVN may exacerbate the anorexic phenotype in the presence of environmental stressors. ..
  18. Hsieh Y, Chen P, Yu C, Chen C, Tsai T, Kuo D. Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats. Neurotoxicology. 2015;48:131-41 pubmed publisher associated with the regulation of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus...
  19. Ferrante C, Orlando G, Recinella L, Leone S, Chiavaroli A, Di Nisio C, et al. Central inhibitory effects on feeding induced by the adipo-myokine irisin. Eur J Pharmacol. 2016;791:389-394 pubmed publisher
    ..peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats...
  20. Recinella L, Leone S, Ferrante C, Chiavaroli A, Di Nisio C, Martinotti S, et al. Effects of central fibroblast growth factor 21 (FGF21) in energy balance. J Biol Regul Homeost Agents. 2017;31:603-613 pubmed
    ..peptide (AgRP) and neuropeptide Y (NPY)] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides, in the hypothalamus, and dopamine (DA) and serotonin (5-..
  21. Zhang J, Sun P, Yang F, Kong T, Zhang R. Tributyltin disrupts feeding and energy metabolism in the goldfish (Carassius auratus). Chemosphere. 2016;152:221-8 pubmed publisher
    ..4 ng/L TBT group, which indicated a complex disrupting effect on metabolism of TBT. In short, TBT can alter feeding and energy metabolism in fish, which might promote the obesogenic responses. ..
  22. Garfield A, Patterson C, Skora S, Gribble F, Reimann F, Evans M, et al. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology. 2012;153:4600-7 pubmed
    ..These data provide new insight into the appetitive brainstem circuits engaged by leptin. ..
  23. Leone S, Ferrante C, Recinella L, Chiavaroli A, Mollica A, Tömböly C, et al. Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats. Neuropeptides. 2018;72:38-46 pubmed publisher
    ..AgRP), neuropeptide Y (NPY), pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and fatty acid amide hydrolase (FAAH) gene expression in the hypothalamus was measured by real-time reverse ..
  24. Diane A, Kupreeva M, Borthwick F, Proctor S, Pierce W, Vine D. Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model. J Endocrinol. 2015;226:193-206 pubmed publisher
    ..increased plasma sex-hormone binding globulin, hypothalamic cocaine-and amphetamine-regulated transcript (CART) and Kisspeptin mRNA expression to levels of the Lean-Control group, and this was further associated with ..
  25. Kastin A, Pan W. Involvement of the Blood-Brain Barrier in Metabolic Regulation. CNS Neurol Disord Drug Targets. 2016;15:1118-1128 pubmed
    ..Thus, the BBB plays a dynamic role in modulating the passage of ingestive peptides from blood to brain. ..
  26. Makowska K, Gonkowski S. The Influence of Inflammation and Nerve Damage on the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Neurons in the Enteric Nervous System of the Porcine Descending Colon. Int J Mol Sci. 2018;19: pubmed publisher
    ..The obtained results show that CGRP-positive enteric neurons are varied in terms of neurochemical characterization and take part in adaptive processes in the descending colon during inflammation and after nerve damage. ..
  27. McConn B, Gilbert E, Cline M. Fasting and refeeding induce differential changes in hypothalamic mRNA abundance of appetite-associated factors in 7 day-old Japanese quail, Coturnix japonica. Comp Biochem Physiol A Mol Integr Physiol. 2018;227:60-67 pubmed publisher
    ..NPYR2, and MC3R and less ORXR2, prolactin releasing peptide (PrRP), cocaine- and amphetamine-regulated transcript (CART), and calcitonin (CAL) mRNA than fed quail...
  28. Hu X, Sheikhahmadi A, Li X, Wang Y, Jiao H, Lin H, et al. Effect of Zinc on Appetite Regulatory Peptides in the Hypothalamus of Salmonella-Challenged Broiler Chickens. Biol Trace Elem Res. 2016;172:228-33 pubmed publisher
    ..This study shows that dietary Zn supplementation promoted orexigenic appetite regulatory peptides and reduced the expression of the inflammatory cytokine TNF-α in the hypothalamus of Salmonella-challenged broilers. ..
  29. Lam D, Zhou L, Vegge A, Xiu P, Christensen B, Osundiji M, et al. Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia. Behav Brain Res. 2009;196:139-43 pubmed publisher
    ..was specific to catecholamine neurons, with negligible induction of cocaine- and amphetamine-regulated transcript (CART), cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), or neurotensin neurons...
  30. Palus K, Całka J. Alterations of neurochemical expression of the coeliac-superior mesenteric ganglion complex (CSMG) neurons supplying the prepyloric region of the porcine stomach following partial stomach resection. J Chem Neuroanat. 2016;72:25-33 pubmed publisher
    ..neurons in all pigs were surrounded by a network of cocaine- and amphetamine-regulated transcript peptide (CART)-, calcitonin gene-related peptide (CGRP)-, and substance P (SP)-, vasoactive intestinal peptide (VIP)-, LENK- and ..
  31. Uranga R, Millán C, Barahona M, Recabal A, Salgado M, Martinez F, et al. Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior. Sci Rep. 2017;7:3697 pubmed publisher
    ..particularly, agouti-related protein (AgRP), neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) neurons...
  32. Lian J, De Santis M, He M, Deng C. Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: The role of histaminergic and NPY pathways. Pharmacol Res. 2015;95-96:20-6 pubmed publisher
    ..did not affect hypothalamic proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) mRNA expression...
  33. Secher A, Jelsing J, Baquero A, Hecksher Sørensen J, Cowley M, Dalbøge L, et al. The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest. 2014;124:4473-88 pubmed publisher
    ..internalized in neurons expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART)...
  34. Sundarrajan L, Unniappan S. Small interfering RNA mediated knockdown of irisin suppresses food intake and modulates appetite regulatory peptides in zebrafish. Gen Comp Endocrinol. 2017;252:200-208 pubmed publisher
    ..Knockdown of irisin reduced ghrelin and orexin-A mRNA expression, and increased cocaine and amphetamine regulated transcript mRNA expression in zebrafish brain and gut...
  35. Lau J, Shi Y, Herzog H. Temperature dependence of the control of energy homeostasis requires CART signaling. Neuropeptides. 2016;59:97-109 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) is a key neuropeptide with predominant expression in the hypothalamus central to the regulation of diverse biological processes, including food intake and energy expenditure...
  36. Janiuk I, Kasacka I. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension. Eur J Histochem. 2015;59:2446 pubmed publisher
    ..The cocaine- and amphetamine-regulated transcript (CART) is a known factor in appetite and feeding behaviour...
  37. Jørgensen E, Bernier N, Maule A, Vijayan M. Effect of long-term fasting and a subsequent meal on mRNA abundances of hypothalamic appetite regulators, central and peripheral leptin expression and plasma leptin levels in rainbow trout. Peptides. 2016;86:162-170 pubmed publisher
    ..The increase in belly flap leptin transcript with fasting, which did not decrease upon re-feeding, indicates a tissue-specific role of leptin in long-term regulation of energy homeostasis. ..
  38. Volkoff H, Estevan Sabioni R, Coutinho L, Cyrino J. Appetite regulating factors in pacu (Piaractus mesopotamicus): Tissue distribution and effects of food quantity and quality on gene expression. Comp Biochem Physiol A Mol Integr Physiol. 2017;203:241-254 pubmed publisher
    ..In this study, transcripts for orexin, cocaine and amphetamine regulated transcript (CART), cholecystokinin (CCK) and leptin were isolated in pacu...
  39. Yu C, Chu S, Chen P, Hsieh Y, Kuo D. Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine. Genes Brain Behav. 2017;16:439-448 pubmed publisher food intake and the expression of neuropeptide Y (NPY), the cocaine- and amphetamine-regulated transcript (CART), superoxide dismutase, catalase, ghrelin, acyl ghrelin (AG), ghrelin O-acyltransferase (GOAT) and the ghrelin ..
  40. Li P, Meng J, Jing J, Hao Q, Zhu Z, Yao J, et al. Study on the relationship between expression patterns of cocaine-and amphetamine regulated transcript and hormones secretion in porcine ovarian follicles. Biol Res. 2018;51:6 pubmed publisher
    Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep...
  41. Bakhtazad A, Vousooghi N, Garmabi B, Zarrindast M. CART peptide and opioid addiction: Expression changes in male rat brain. Neuroscience. 2016;325:63-73 pubmed publisher
    Previous studies have shown the prominence of cocaine- and amphetamine-regulated transcript (CART) peptide in rewarding and reinforcing effects of drugs of abuse specially psychostimulants...
  42. Bharne A, Borkar C, Bodakuntla S, Lahiri M, Subhedar N, Kokare D. Pro-cognitive action of CART is mediated via ERK in the hippocampus. Hippocampus. 2016;26:1313-27 pubmed publisher
    Although cocaine- and amphetamine-regulated transcript peptide (CART) is detected in several cortical and subcortical areas, its role in higher functions has been largely ignored...
  43. Donato J, Cavalcante J, Silva R, Teixeira A, Bittencourt J, Elias C. Male and female odors induce Fos expression in chemically defined neuronal population. Physiol Behav. 2010;99:67-77 pubmed publisher
    ..The majority of the PMV neurons expressing NADPHd colocalized cocaine- and amphetamine-regulated transcript (CART)...
  44. Margulska A, Kozłowska E, Wysokiński A. Effect of clozapine dose and concentration on fasting concentration of appetite regulating peptides. Psychiatry Res. 2018;260:473-477 pubmed publisher
    ..whether clozapine serum concentration may affect fasting serum levels of several appetite regulating peptides: CART, PYY(1-36), NPY, AgRP, des-acylated ghrelin, leptin and obestatin...
  45. Landerholm K, Falkmer S, Järhult J, Sundler F, Wierup N. Cocaine- and amphetamine-regulated transcript in neuroendocrine tumors. Neuroendocrinology. 2011;94:228-36 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic regulatory peptide highly expressed in the brain's appetite control centers, but also in peripheral neurons and in endocrine cells in the adrenal medulla, thyroid, ..
  46. Cavalcante J, Cândido P, Sita L, do Nascimento E, Cavalcante J, De Oliveira Costa M, et al. Comparative distribution of cocaine- and amphetamine-regulated transcript (CART) in the hypothalamus of the capuchin monkey (Cebus apella) and the common marmoset (Callithrix jacchus). Brain Res. 2011;1425:47-61 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) is widely distributed in the brain of many species...
  47. Bulc M, Gonkowski S, Całka J. Expression of Cocaine and Amphetamine Regulated Transcript (CART) in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes Mellitus. J Mol Neurosci. 2015;57:376-85 pubmed publisher
    ..effect of streptozotocin-induced diabetes on the cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) enteric nervous structures was investigated within the porcine stomach...
  48. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..the expression of both the hypothalamic orexigenic neuropeptide Y (NPY) and anorexigenic cocaine and amphetamine regulated transcript (CART) in chick brain which may explain the similar feed intake between the two groups...
  49. Long Y, Bordt A, Liu W, Davis E, Lee S, Tseng L, et al. Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART). Peptides. 2016;84:22-35 pubmed publisher
    The goals of this study were to localize the neuropeptide Cocaine- and Amphetamine-Regulated Transcript (CART) in primate retinas and to describe the morphology, neurotransmitter content and synaptic connections of the neurons that ..
  50. Slattery M, Lundgreen A, Hines L, Wolff R, Torres Mejia G, Baumgartner K, et al. Energy homeostasis genes and breast cancer risk: The influence of ancestry, body size, and menopausal status, the breast cancer health disparities study. Cancer Epidemiol. 2015;39:1113-22 pubmed publisher
    ..05), as was cocaine and amphetamine regulated transcript protein (CARTPT) (PARTP=0.014) and ghrelin (GHRL) (PARTP=0.007)...
  51. Suglia A, Chianese R, Migliaccio M, Ambrosino C, Fasano S, Pierantoni R, et al. Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice. Pharmacol Res. 2016;113:376-383 pubmed publisher
    ..This observation suggests that Bisphenol A induces activation of anorexigenic signals via down-regulation of the hypothalamic cannabinoid receptor 1 with negative impact on food intake. ..
  52. Geloneze B, de Lima Júnior J, Velloso L. Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in the Brain-Adipocyte Axis. Drugs. 2017;77:493-503 pubmed publisher
    ..anorexigenic anorectic neuropeptides proopiomelanocortin and cocaine- and amphetamine-regulated transcript (POMC/CART)...
  53. Parcianello R, Mardini V, Ceresér K, Langleben D, Xavier F, Zavaschi M, et al. Increased cocaine and amphetamine-regulated transcript cord blood levels in the newborns exposed to crack cocaine in utero. Psychopharmacology (Berl). 2018;235:215-222 pubmed publisher
    Cocaine and amphetamine-regulated transcript (CART) is an endogenous antioxidant present since the embryonic period...
  54. Borkar C, Bharne A, Nagalakshmi B, Sakharkar A, Subhedar N, Kokare D. Cocaine- and Amphetamine-Regulated Transcript Peptide (CART) Alleviates MK-801-Induced Schizophrenic Dementia-Like Symptoms. Neuroscience. 2018;375:94-107 pubmed publisher
    ..Since cocaine- and amphetamine-regulated transcript peptide (CART) modulates actions of dopamine as well as glutamate, we tested the role of this peptide in MK-801-induced ..
  55. Wan Long Z, Zheng Kun W. Effects of random food deprivation and refeeding on energy metabolism, behavior and hypothalamic neuropeptide expression in Apodemus chevrieri. Comp Biochem Physiol A Mol Integr Physiol. 2016;201:71-78 pubmed publisher
    ..and thermogenesis, leptin levels, pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) expressions decreased in FD compared with controls...
  56. Kumar S, Singh U, Goswami C, Singru P. Transient receptor potential vanilloid 5 (TRPV5), a highly Ca2+ -selective TRP channel in the rat brain: relevance to neuroendocrine regulation. J Neuroendocrinol. 2017;29: pubmed publisher
    ..relevance of TRPV5, we focused on vasopressin, oxytocin and cocaine- and amphetamine-regulated transcript (CART) as representative candidate markers with which TRPV5 may co-exist...
  57. Striberny A, Jørgensen E. Feedback from Arctic charr: Feed flavour stimulation and re-feeding after feed deprivation stimulate genes encoding both orexigenic and anorexigenic neuropeptides. Gen Comp Endocrinol. 2017;246:71-80 pubmed publisher
    ..We suggest that changes in gene expression are more likely to be registered during transition phases, e.g. from fasting to feeding and upon stimulatory inputs such as feed flavour. ..
  58. Zacharko Siembida A, Matysek M, Szalak R, Radlinska A, Obszańska K, Arciszewski M. Distribution and immunohistochemical characteristics of cocaine- and amphetamineregulated transcript-positive nerve elements in the pelvic ganglia of the female pig. Pol J Vet Sci. 2017;20:173-183 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) peptides are widely expressed not only in the brain but also in numerous endocrine/neuroendocrine cells as well as in neurons of the peripheral nervous system...
  59. Najdzion J. Cocaine- and amphetamine-regulated transcript peptide and calcium binding proteins immunoreactivity in the deep layers of the superior colliculus of the guinea pig: Implications for multisensory and visuomotor processing. J Chem Neuroanat. 2018;88:55-69 pubmed publisher
    ..the pattern of distribution and colocalization of cocaine- and amphetamine-regulated transcript peptide (CART) and three calcium-binding proteins (CaBPs) i.e...
  60. Mo C, Cai G, Huang L, Deng Q, Lin D, Cui L, et al. Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary. Mol Cell Endocrinol. 2015;417:166-77 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) peptide(s) is generally viewed as neuropeptide(s) and can control food intake in vertebrates, however, our recent study revealed that CART1 peptide is predominantly expressed in chicken ..
  61. Palus K, Całka J. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach. PLoS ONE. 2015;10:e0143661 pubmed publisher
    ..nitric oxide synthase (nNOS), leu 5-enkephalin (LENK), cocaine- and amphetamine- regulated transcript peptide (CART), calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal peptide (VIP)...
  62. Ansari A, Bose S, Yadav M, Wang J, Song Y, Ko S, et al. CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice. Molecules. 2016;21: pubmed
    ..Our findings reveal that the anti-obesity impact of CST is mediated through modulation of metabolism-related neuropeptides, adipokines, and gut microbial composition. ..
  63. Smith Y, Kieval J, Couceyro P, Kuhar M. CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents. J Comp Neurol. 1999;407:491-511 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) is a novel mRNA whose level of expression was found to be increased in the striatum after acute administration of psychomotor stimulants in rats...
  64. Yamamoto N, Nakayama J, Yamakawa Kobayashi K, Hamaguchi H, Miyazaki R, Arinami T. Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension. Hum Mutat. 2002;19:251-7 pubmed
    ..3 for presence of the Arg allele at codon 528, in comparison with presence of the Lys/Lys genotype (P = 0.004). These findings support involvement of ALAP in the regulation of blood pressure. ..
  65. Keller P, Compan V, Bockaert J, Giacobino J, Charnay Y, Bouras C, et al. Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites. Peptides. 2006;27:1328-34 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) is widely expressed in the brain and various endocrine tissues. CART is implicated in many physiological functions including food intake, drug reward, stress and nociception...
  66. Hsu C, Tzang R, Loh E, Liou Y, Hong C, Tsai S. Family-based association study of cocaine- and amphetamine-regulated transcript (CARTPT) and protein interaction with C-kinase-1 (PICK1) genes in attention-deficit hyperactivity disorder. Psychiatry Res. 2012;198:334-5 pubmed publisher
  67. Khor S, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, et al. Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia. Peerj. 2013;1:e66 pubmed publisher
    ..This is the first GWAS of HLA-DQB1*06:02 negative EHS, and the identification of these three new susceptibility loci should provide additional insights to the pathophysiological pathway of this condition. ..
  68. Wysokiński A, Kłoszewska I. Blood serum levels of CART peptide in patients with schizophrenia on clozapine monotherapy. Psychiatry Res. 2014;220:170-4 pubmed publisher
    b>CART (cocaine- and amphetamine-regulated transcript) is an endogenous inhibitor of food intake...
  69. Jayanthi S, Gonzalez B, McCoy M, Ladenheim B, Bisagno V, Cadet J. Methamphetamine Induces TET1- and TET3-Dependent DNA Hydroxymethylation of Crh and Avp Genes in the Rat Nucleus Accumbens. Mol Neurobiol. 2018;55:5154-5166 pubmed publisher
    ..These results provide molecular evidence for epigenetic controls of METH-induced changes in the expression of neuropeptides. ..
  70. Aja S, Schwartz G, Kuhar M, Moran T. Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1613-9 pubmed
    Intracerebroventricular administration of cocaine- and amphetamine-regulated transcript (CART) peptides reduces food intake and increases c-Fos in brain areas involved in the control of feeding...
  71. Loos R, Rankinen T, Tremblay A, Perusse L, Chagnon Y, Bouchard C. Melanocortin-4 receptor gene and physical activity in the Québec Family Study. Int J Obes (Lond). 2005;29:420-8 pubmed
    ..MC3R), neuropeptide-Y (NPY), neuropeptide-Y Y1 receptor (NPY Y1R), cocaine- and amphetamine-regulated transcript (CART), agouti-related protein (AGRP), and pro-opiomelanocortin (POMC) genes in 669 subjects (age (X+/-s.d...
  72. Lohoff F, Bloch P, Weller A, Nall A, Doyle G, Buono R, et al. Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. Neurosci Lett. 2008;440:280-3 pubmed publisher
  73. Chowdhury N, Souza R, Tiwari A, Brandl E, Sicard M, Meltzer H, et al. Investigation of melanocortin system gene variants in antipsychotic-induced weight gain. World J Biol Psychiatry. 2014;15:251-8 pubmed publisher
    ..populations of neurons expressed in the hypothalamus, including the cocaine- and amphetamine-regulated transcript (CART), the polypeptide pro-opiomelanocortin (POMC) and the agouti-related protein (AGRP), have regulatory roles in ..
  74. Krasnova I, Gerra M, Walther D, Jayanthi S, Ladenheim B, McCoy M, et al. Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats. Sci Rep. 2017;7:8331 pubmed publisher
    ..These observations support a regional role of neuropeptides in the brain after a long withdrawal interval when animals show incubation of methamphetamine craving. ..
  75. Dominguez G, del Giudice E, Kuhar M. CART peptide levels are altered by a mutation associated with obesity at codon 34. Mol Psychiatry. 2004;9:1065-6 pubmed
  76. Vasseur F, Guerardel A, Barat Houari M, Cottel D, Amouyel P, Froguel P, et al. Impact of a CART promoter genetic variation on plasma lipid profile in a general population. Mol Genet Metab. 2007;90:199-204 pubmed
    The cocaine and amphetamine regulated transcript (CART), an anorexigenic peptide responding to leptin, is expressed in various areas of the hypothalamus...
  77. Vasseur F, Caeyseele T, Barat Houari M, Lobbens S, Meirhaeghe A, Meyre D, et al. Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. J Hum Genet. 2010;55:227-31 pubmed publisher
    ..13, 95% CI=2.20-4.46, P<0.0001). Our results suggest that in interaction with BMI, ADIPOQ haplotypes capture genetic variation(s) from neighboring gene(s) that would modulate LDL-C level. ..
  78. Kasacka I, Janiuk I, Lewandowska A, Bekisz A, Lebkowski W. Distribution pattern of CART-containing neurons and cells in the human pancreas. Acta Histochem. 2012;114:695-9 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) has been shown to play a critical role in appetite suppression, cell survival, thermoregulation, glucose sensing, stimulation of hormone secretion, as well as for the regulatory ..
  79. Shcherbina L, Edlund A, Esguerra J, Abels M, Zhou Y, Ottosson Laakso E, et al. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes. Mol Cell Endocrinol. 2017;447:52-60 pubmed publisher
    ..Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties...
  80. Rale A, Shendye N, Bodas D, Subhedar N, Ghose A. CART neuropeptide modulates the extended amygdalar CeA-vBNST circuit to gate expression of innate fear. Psychoneuroendocrinology. 2017;85:69-77 pubmed publisher
    ..In this study, we identify cocaine- and amphetamine-regulated transcript (CART) neuropeptide signaling in the central amygdala (CeA) - ventral bed nucleus of stria terminalis (vBNST) axis as a ..
  81. Lau J, Farzi A, Enriquez R, Shi Y, Herzog H. GPR88 is a critical regulator of feeding and body composition in mice. Sci Rep. 2017;7:9912 pubmed publisher
    ..Together, our results indicate that GPR88 signalling is not only important for reward processes, but also plays a role in the central regulatory circuits for energy homeostasis. ..
  82. Jung S, Hong M, Suh G, Jin S, Lee H, Kim B, et al. Association between polymorphism in intron 1 of cocaine- and amphetamine-regulated transcript gene with alcoholism, but not with bipolar disorder and schizophrenia in Korean population. Neurosci Lett. 2004;365:54-7 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) peptide is a novel neuropeptide involved in feeding, drug reward, and stress...
  83. Stein J, Steiner D, Dey A. Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications. Peptides. 2006;27:1919-25 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) peptides are expressed in several neuroendocrine tissues, including hypothalamus, pituitary, gut, adrenal and pancreas, and are involved in regulating important biological processes ..
  84. Bloem B, Xu L, Morava E, Faludi G, Palkovits M, Roubos E, et al. Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls. Neuropharmacology. 2012;62:297-303 pubmed publisher
    ..In rodents, cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/NUCB2 have not only been implicated in metabolism, but in the pathobiology of anxiety and ..
  85. Mao P, Meshul C, Thuillier P, Goldberg N, Reddy P. CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria. PLoS ONE. 2012;7:e29343 pubmed publisher
    The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART) is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system...
  86. Kasacka I, Piotrowska Z, Car H, Janiuk I, Lebkowski W. Cocaine- and amphetamine-regulated transcript : identification and distribution in human gastrointestinal tract. J Biol Regul Homeost Agents. 2012;26:419-28 pubmed
    Cocaine- and amphetamine-regulated transcript (CART) was identified in the central and peripheral nervous system, including the gastrointestinal tract of rodents and pig...
  87. Chun E, Kim H, Suh C, Kim J, Kim D, Kim J. Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women. Menopause. 2015;22:1256-63 pubmed publisher
    ..Twenty polymorphisms in NMU (neuromedin U; two polymorphisms), NMU2R (NMU receptor 2; six polymorphisms), CART (cocaine- and amphetamine-regulated transcript; three polymorphisms), NPY (neuropeptide Y; four polymorphisms), ..
  88. Butt Z, Hackett J, Volkoff H. Irisin in goldfish (Carassius auratus): Effects of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 expression. Peptides. 2017;90:27-36 pubmed publisher
    ..of irisin on feeding behavior, glucose levels and the mRNA expressions of appetite regulators (cocaine and amphetamine regulated transcript CART, agouti related protein AgRP, orexin), UCPs and lipoprotein lipase LPL and brain factors (..
  89. Makowska K, Obremski K, Zielonka L, Gonkowski S. The Influence of Low Doses of Zearalenone and T-2 Toxin on Calcitonin Gene Related Peptide-Like Immunoreactive (CGRP-LI) Neurons in the ENS of the Porcine Descending Colon. Toxins (Basel). 2017;9: pubmed publisher
    ..The obtained results demonstrate that even low doses of ZEN and T-2 can affect living organisms and cause changes in the neurochemical profile of enteric neurons. ..
  90. Blanco E, Zúñiga J, Andrés M, Alvarez A, Gysling K. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Neuropeptides. 2011;45:273-9 pubmed publisher
    ..Thus, our results show that CRF-BP is efficiently sorted to the regulated secretory pathway in two cellular contexts, suggesting that the extracellular levels of CRF-BP in the central nervous system depends on neuronal activity. ..
  91. Brennan D, O Connor D, Laursen H, McGee S, McCarthy S, Zagozdzon R, et al. The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ER?, and is an independent prognostic factor in node-negative breast cancer. Oncogene. 2012;31:3483-94 pubmed publisher tissue microarray and automated image analysis that the cocaine- and amphetamine-regulated transcript (CART) is expressed in primary and metastatic breast cancer and is an independent poor prognostic factor in estrogen ..
  92. Yilmaz O, Calan M, Kume T, Yesil P, Isik D. Lower cocaine- and amphetamine-regulated transcript levels pose a risk for developing PCOS. Horm Metab Res. 2014;46:702-6 pubmed publisher
    Cocaine- and amphetamine-regulated transcript (CART) is an anorectic neuropeptide abundantly expressed in the central, peripheral, and enteric nervous systems, as well as in several different endocrine cell types...