Gene Symbol: CNTFR
Description: ciliary neurotrophic factor receptor
Alias: ciliary neurotrophic factor receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha
Species: human
Products:     CNTFR

Top Publications

  1. Lelievre E, Plun Favreau H, Chevalier S, Froger J, Guillet C, Elson G, et al. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J Biol Chem. 2001;276:22476-84 pubmed
    ..Its receptor complex consists of a ligand-binding component, CNTF receptor (CNTFR), associated with two signaling receptor components, gp130 and leukemia inhibitory factor receptor (LIFR)...
  2. Davis S, Aldrich T, Valenzuela D, Wong V, Furth M, Squinto S, et al. The receptor for ciliary neurotrophic factor. Science. 1991;253:59-63 pubmed
    ..In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage. ..
  3. Mao S, Li X, Wang J, Ding X, Zhang C, Li L. miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions. J Neuroinflammation. 2016;13:208 pubmed publisher
    ..miR-17-92 cluster repressed the expression of multiple proteins including GP130, CNTFR, JAK2, and STAT3 in JAK-STAT pathway...
  4. Li C, Cai W, Zhou C, Yin H, Zhang Z, Loor J, et al. RNA-Seq reveals 10 novel promising candidate genes affecting milk protein concentration in the Chinese Holstein population. Sci Rep. 2016;6:26813 pubmed publisher
    ..Integrated interpretation of differential gene expression indicated that SERPINA1, CLU, CNTFR, ERBB2, NEDD4L, ANG, GALE, HSPA8, LPAR6 and CD14 are the most promising candidate genes affecting milk protein ..
  5. Miyamoto Mikami E, Fujita Y, Murakami H, Ito M, Miyachi M, Kawahara T, et al. CNTFR Genotype and Sprint/power Performance: Case-control Association and Functional Studies. Int J Sports Med. 2016;37:411-7 pubmed publisher investigate whether rs41274853 in the 3'-untranslated region of the ciliary neurotrophic factor receptor gene (CNTFR) is associated with elite sprint/power athletic status and assess its functional significance...
  6. Jalvy S, Veschambre P, Fedou S, Rezvani H, Theze N, Thiebaud P. Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor. Dev Biol. 2019;447:200-213 pubmed publisher
    ..ciliary neurotrophic factor (CNTF), cardiotrophin like cytokine factor 1 (CLCF1), LIFR, IL6ST, IL6R, IL11RA and CNTFR. Lif mRNA is zygotically expressed after midblastula transition while lifr and il6st are maternally expressed...
  7. Pasquin S, Sharma M, Gauchat J. Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. Cytokine Growth Factor Rev. 2015;26:507-15 pubmed publisher
    ..side effects of CNTF might be linked to its ability to activate the alternative IL6Rα-LIFRβ-gp130 receptor, CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRα-LIFRβ-gp130 receptor...
  8. Cousinery M, Li R, Vannitamby A, Vikraman J, Southwell B, Hutson J. Neurotrophin signaling in a genitofemoral nerve target organ during testicular descent in mice. J Pediatr Surg. 2016;51:1321-6 pubmed publisher
    ..and fluorescent immunohistochemistry for ciliary neurotrophic factor (CNTF), ciliary neurotrophic factor receptor (CNTFR) and cell nuclei (DAPI)...
  9. Ibeagha Awemu E, Li R, Ammah A, Dudemaine P, Bissonnette N, Benchaar C, et al. Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways. BMC Genomics. 2016;17:104 pubmed publisher
    ..Involvement of SCP2, PDK4, NQO1, F2RL1, DBI, CPT1A, CNTFR, CALB1, ACADVL, SPTLC3, PIK3CG, PIGZ, ADORA2B, TRIB3, HPGD, IGFBP2 and TXN in FA/lipid metabolism in dairy cows is ..

More Information


  1. Agresta A, Fasciani R, Padua L, Petroni S, La Torraca I, Dickmann A, et al. Corneal alterations in Crisponi/CISS1 syndrome: A slit-lamp biomicroscopy and in vivo confocal microscopy corneal report. Ophthalmic Genet. 2017;38:83-87 pubmed publisher
    ..The protein encoded is a soluble cytokine receptor, involved in the ciliary neurotrophic factor receptor (CNTFR) pathway...
  2. Miyamoto Mikami E, Murakami H, Tsuchie H, Takahashi H, Ohiwa N, Miyachi M, et al. Lack of association between genotype score and sprint/power performance in the Japanese population. J Sci Med Sport. 2017;20:98-103 pubmed publisher
    ..0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with ..
  3. Ramli N, Ismail P, Rahmat A. Red pitaya juice supplementation ameliorates energy balance homeostasis by modulating obesity-related genes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats. BMC Complement Altern Med. 2016;16:243 pubmed publisher
    ..weight, developed excess abdominal fat deposition and down-regulated the expression level of IL-1?, IL-1r1, and Cntfr as compared to the control group...
  4. Kuroda H, Sugimoto T, Horii Y, Sawada T. Signaling pathway of ciliary neurotrophic factor in neuroblastoma cell lines. Med Pediatr Oncol. 2001;36:118-21 pubmed
    ..composed of the IL-6 signal transducing molecule gp130, leukemia inhibitory factor receptor (LIFR)-beta, and CNTFR-alpha...
  5. Elson G, Lelievre E, Guillet C, Chevalier S, Plun Favreau H, Froger J, et al. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat Neurosci. 2000;3:867-72 pubmed
    ..Its receptor complex consists of a non-signaling alpha chain, CNTFR, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (LIFR)...
  6. Lu J, Ksendzovsky A, Yang C, Mehta G, Yong R, Weil R, et al. CNTF receptor subunit α as a marker for glioma tumor-initiating cells and tumor grade: laboratory investigation. J Neurosurg. 2012;117:1022-1031 pubmed publisher
    ..analyses were used to confirm findings of upregulated ciliary neurotrophic factor receptor subunit-α (CNTFRα) in undifferentiated tumor-initiating cells and gliomas of increasing tumor grade...
  7. Rousseau F, Gauchat J, McLeod J, Chevalier S, Guillet C, Guilhot F, et al. Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. Proc Natl Acad Sci U S A. 2006;103:10068-73 pubmed
    ..Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha. ..
  8. De Mars G, Windelinckx A, Beunen G, Delecluse C, Lefevre J, Thomis M. Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. J Appl Physiol (1985). 2007;102:1824-31 pubmed
    Genotypic associations between polymorphisms in the ciliary neurotrophic factor (CNTF) and CNTF receptor (CNTFR) genes and muscular strength phenotypes in 154 middle-aged men (45-49 yr) and 138 women (38-44 yr) and 99 older men (60-78 yr)..
  9. Roth S, Metter E, Lee M, Hurley B, Ferrell R. C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women. J Appl Physiol (1985). 2003;95:1425-30 pubmed
    We performed gene screening of the ciliary neurotrophic factor receptor (CNTFR) gene and genotyped three newly identified polymorphisms: C-1703T in the 5' promoter region, T1069A in intron 5, and C174T in exon 9...
  10. Milman T, Hu D, McCormick S, Eagle R, Crawford J, Chin K, et al. Expression of neurotrophin receptors by retinoinvasive uveal melanoma. Melanoma Res. 2012;22:164-8 pubmed publisher
    ..This study failed to demonstrate a direct causation between the expression of neurotrophin receptors and a retinoinvasive uveal melanoma growth pattern. ..
  11. Hu X, Zhao Y, He X, Li J, Wang T, Zhou W, et al. Ciliary neurotrophic factor receptor alpha subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications. Hepatology. 2008;47:1298-308 pubmed publisher
    ..roles in a variety of tissues including neural and non-neural systems, but the function of CNTF and its receptor (CNTFR) in liver remains unclear...
  12. Mercader J, Saus E, Aguera Z, Bayés M, Boni C, Carreras A, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet. 2008;17:1234-44 pubmed publisher
    ..covering 10 neurotrophin signaling genes: NGFB, BDNF, NTRK1, NGFR/p75, NTF4/5, NTRK2, NTF3, NTRK3, CNTF and CNTFR in 371 ED trios of Spanish, French and German origin...
  13. Skiniotis G, Lupardus P, Martick M, Walz T, Garcia K. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol Cell. 2008;31:737-48 pubmed publisher
    ..These studies also enumerate the organizing principles for assembly of the "tall" class of gp130 family cytokine receptor complexes including LIF, IL-27, IL-12, and others. ..
  14. Wagener E, Aurich M, Aparicio Siegmund S, Floss D, Garbers C, Breusing K, et al. The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR). J Biol Chem. 2014;289:18442-50 pubmed publisher
    ..CNTF binds to high or low affinity receptor complexes consisting of CNTFR·gp130·LIFR or IL-6R·gp130·LIFR, respectively...
  15. Liu J, Shi M, Hong Z, Zhang J, Bradner J, Quinn T, et al. Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein. Proteomics. 2010;10:2138-50 pubmed publisher
    ..One was ciliary neurotrophic factor receptor, which appeared to modulate eSNCA-mediated neurotoxicity via mechanisms related to JAK1/STAT3 signaling but independent of eSNCA endocytosis. ..
  16. Li R, Wen R, Banzon T, Maminishkis A, Miller S. CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS ONE. 2011;6:e23148 pubmed publisher
    ..Cultured hfRPE express CNTF, CT1, and OsM and their receptors, including CNTFR?, LIFR?, gp130, and OsMR?, all localized mainly at the apical membrane...
  17. Perret D, Guillet C, Elson G, Froger J, Plun Favreau H, Rousseau F, et al. Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines. J Biol Chem. 2004;279:43961-70 pubmed
    ..This study establishes the molecular details of the interaction of CLC with CLF, CNTFRalpha, and LIFRbeta and helps to define the precise role of each protein in this functional receptor complex. ..
  18. Valenzuela D, Rojas E, Le Beau M, Espinosa R, Brannan C, McClain J, et al. Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. Genomics. 1995;25:157-63 pubmed
    ..However, the CNTF receptor complex also includes a CNTF-specific component known as CNTF receptor alpha (CNTFR alpha). Here we describe the molecular cloning of the human and mouse genes encoding CNTFR...
  19. Hashimoto Y, Kurita M, Aiso S, Nishimoto I, Matsuoka M. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol Biol Cell. 2009;20:2864-73 pubmed publisher
    ..Overexpression of ciliary neurotrophic factor receptor alpha (CNTFR) and/or the IL-27 receptor subunit, WSX-1, but not that of any other tested gp130-related receptor subunit, up-..
  20. He W, Gong K, Zhu G, Smith D, Ip N. Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro. FEBS Lett. 2002;514:214-8 pubmed
    ..The functional receptor complex of CNTF is composed of the CNTF receptor alpha (CNTFR), gp130 and the leukemia inhibitory factor receptor (LIFR)...
  21. Plun Favreau H, Elson G, Chabbert M, Froger J, Delapeyriere O, Lelievre E, et al. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 2001;20:1692-703 pubmed
    ..inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha component (CNTFR). CNTFR-deficient mice show profound neuronal deficits at birth, leading to a lethal phenotype...
  22. Gratacos M, Escaramis G, Bustamante M, Saus E, Aguera Z, Bayés M, et al. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. J Psychiatr Res. 2010;44:834-40 pubmed publisher
    ..model approach to include prior genetic knowledge of the specific and found that variants in CNTF, in its receptor CNTFR, and in NTRK2 were significantly associated with a lower age at onset of the ED...
  23. Man D, He W, Sze K, Gong K, Smith D, Zhu G, et al. Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J Biol Chem. 2003;278:23285-94 pubmed
    ..factor (CNTF), a member of the gp130 family of cytokines, is composed of CNTF, the CNTF receptor alpha (CNTFR), gp130, and the leukemia inhibitory factor receptor (LIFR)...
  24. Tzang R, Hsu C, Liou Y, Hong C, Tsai S. Family-based association study of ciliary neurotrophic factor receptor and norepinephrine transporter genes in attention-deficit hyperactivity disorder. Psychiatr Genet. 2014;24:118-9 pubmed publisher
  25. Donaldson D, Britt D, Jones C, Jackson C, Patterson D. Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. Genomics. 1993;17:782-4 pubmed
    ..CNTF therefore holds promise as a treatment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familial ALS...
  26. Sleeman M, Anderson K, Lambert P, Yancopoulos G, Wiegand S. The ciliary neurotrophic factor and its receptor, CNTFR alpha. Pharm Acta Helv. 2000;74:265-72 pubmed
    ..The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous ..
  27. Robledo O, Auguste P, Coupey L, Praloran V, Chevalier S, Pouplard A, et al. Binding interactions of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors. J Neurochem. 1996;66:1391-9 pubmed
  28. DeChiara T, Vejsada R, Poueymirou W, Acheson A, Suri C, Conover J, et al. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 1995;83:313-22 pubmed
    ..have generated and directly compared mice containing null mutations in the genes encoding CNTF or its receptor (CNTFR alpha). Unlike mice lacking CNTF, mice lacking CNTFR alpha die perinatally and display severe motor neuron deficits...
  29. Böttger E, Grangeiro de Carvalho E, Meese S, Kun J, Esen M. Expression of interleukin-6 family receptors in NK92 cells is regulated by cytokines and not through direct interaction with Plasmodium falciparum-infected erythrocytes. J Interferon Cytokine Res. 2013;33:65-71 pubmed publisher
    ..erythrocytes on the regulation of interleukin (IL)-6 receptor (IL-6R), ciliary neurotrophic factor alpha (CNTFR-?) and glycoprotein (gp)130 in natural killer (NK) cells in the context of malaria, we assessed their gene ..
  30. Dagoneau N, Bellais S, Blanchet P, Sarda P, al Gazali L, Di Rocco M, et al. Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. Am J Hum Genet. 2007;80:966-70 pubmed
    ..heterodimer competes with ciliary neurotrophic factor for binding to the ciliary neurotrophic factor receptor (CNTFR) complex...
  31. Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, et al. Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem. 2003;278:9528-35 pubmed
    ..Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha-receptor (CNTFR), which is not involved in signal transduction, and the beta-receptors gp130 and leukemia inhibitory factor ..
  32. Saggio I, Paonessa G, Gloaguen I, Graziani R, De Serio A, Laufer R. Nonradioactive receptor binding assay for ciliary neurotrophic factor. Anal Biochem. 1994;221:387-91 pubmed
    ..The possibility of assaying cytokines in crude bacterial extracts makes the new technique particularly suitable for rapidly determining the receptor binding potencies of genetically engineered CNTF variants. ..