CNR1

Summary

Gene Symbol: CNR1
Description: cannabinoid receptor 1
Alias: CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1, cannabinoid receptor 1 (brain), central cannabinoid receptor
Species: human
Products:     CNR1

Top Publications

  1. Kempf K, Hector J, Strate T, Schwarzloh B, Rose B, Herder C, et al. Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. Horm Metab Res. 2007;39:596-600 pubmed
    ..Therefore, expression of fatty acid amide hydrolase (FAAH), cannabinoid receptor 1 (Cb1), adiponectin, and tumor necrosis factor (TNF)-alpha was compared in visceral adipose tissue from 10 ..
  2. Hutchison K, Haughey H, Niculescu M, Schacht J, Kaiser A, Stitzel J, et al. The incentive salience of alcohol: translating the effects of genetic variant in CNR1. Arch Gen Psychiatry. 2008;65:841-50 pubmed publisher
    The gene that codes for cannabinoid receptor 1 (CNR1) represents an important target for investigations designed to elucidate individual differences in the etiology of alcohol dependence...
  3. Zuo L, Kranzler H, Luo X, Covault J, Gelernter J. CNR1 variation modulates risk for drug and alcohol dependence. Biol Psychiatry. 2007;62:616-26 pubmed
    Human cannabinoid receptor 1 (CB1), which is encoded by the CNR1 gene, may play a role in the development of substance dependence (SD)...
  4. Horne A, Phillips J, Kane N, Lourenco P, McDonald S, Williams A, et al. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS ONE. 2008;3:e3969 pubmed publisher
    ..In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct...
  5. Sugamura K, Sugiyama S, Fujiwara Y, Matsubara J, Akiyama E, Maeda H, et al. Cannabinoid 1 receptor blockade reduces atherosclerosis with enhances reverse cholesterol transport. J Atheroscler Thromb. 2010;17:141-7 pubmed
    A recent clinical study using coronary intravascular ultrasound showed that rimonabant, a cannabinoid 1 (CB1) receptor antagonist, significantly reduced total atheroma volume, suggesting that CB1 receptor blockade could be beneficial in ..
  6. Ballon N, Leroy S, Roy C, Bourdel M, Charles Nicolas A, Krebs M, et al. (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Pharmacogenomics J. 2006;6:126-30 pubmed
    ..We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population...
  7. Cudaback E, Marrs W, MOELLER T, Stella N. The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas. PLoS ONE. 2010;5:e8702 pubmed publisher
  8. Camilleri M, Kolar G, Vazquez Roque M, Carlson P, Burton D, Zinsmeister A. Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits. Am J Physiol Gastrointest Liver Physiol. 2013;304:G553-60 pubmed publisher
    Genetic variations in metabolism of endocannabinoids and in CNR1 (gene for cannabinoid 1 receptor) are associated with symptom phenotype, colonic transit, and left colon motility in irritable bowel syndrome (IBS)...
  9. Haughey H, Marshall E, SCHACHT J, Louis A, Hutchison K. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction. 2008;103:1678-86 pubmed publisher
    ..were associated with polymorphisms within two genes involved in regulating the endocannabinoid system, cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH)...

More Information

Publications79

  1. Löfgren P, Sjölin E, Wahlen K, Hoffstedt J. Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level. J Clin Endocrinol Metab. 2007;92:1555-9 pubmed
    The cannabinoid receptor 1 gene (CNR1) is implicated in adipocyte function. We investigated human adipose tissue CNR1 mRNA in relation to obesity, clinical and metabolic variables, adipocyte function, and adiponectin (ADIPOQ) levels...
  2. Siegfried Z, Kanyas K, Latzer Y, Karni O, Bloch M, Lerer B, et al. Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes. Am J Med Genet B Neuropsychiatr Genet. 2004;125B:126-30 pubmed
    ..hypothesis whether a polymorphism of the CNR1 gene, which encodes human CB1 receptor, a subclass of the central cannabinoid receptor, contributes to the susceptibility to AN...
  3. Wang D, Wang H, Ning W, Backlund M, Dey S, DuBois R. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res. 2008;68:6468-76 pubmed publisher
    ..Here we show that CB1 expression was silenced in human colorectal cancer due to methylation of the CB1 promoter...
  4. Börner C, Bedini A, Hollt V, Kraus J. Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes. Mol Pharmacol. 2008;73:1013-9 pubmed
    The majority of effects of cannabinoids are mediated by the two receptors CB1 and CB2. In addition to neuronal cells, CB1 receptors are expressed in T lymphocytes, in which they are involved in cannabinoid-induced T helper cell biasing...
  5. Bluher M, Engeli S, Kloting N, Berndt J, Fasshauer M, Batkai S, et al. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. 2006;55:3053-60 pubmed
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes. ..
  6. Sarzani R, Bordicchia M, Marcucci P, Bedetta S, Santini S, Giovagnoli A, et al. Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients. Metabolism. 2009;58:361-7 pubmed publisher
    ..activity of the endocannabinoid system in visceral adipose tissue (VAT) may be mediated by cannabinoid type 1 (CB1) receptor expression...
  7. Catani M, Gasperi V, Catanzaro G, Baldassarri S, Bertoni A, Sinigaglia F, et al. Human platelets express authentic CB? and CB? receptors. Curr Neurovasc Res. 2010;7:311-8 pubmed
    ..It seems remarkable that some of these substances have been already used in humans to treat disease states. ..
  8. Ho B, Wassink T, Ziebell S, Andreasen N. Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res. 2011;128:66-75 pubmed publisher
    ..b>Cannabinoid receptor 1 (CB1/CNR1) is the principal brain receptor mediating marijuana effects...
  9. Wei Y, Wang X, Wang L. Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. Mol Vis. 2009;15:1243-51 pubmed
    ..Here we analyzed the expression of and changes in cannabinoid receptors (CB1 and CB2) and one enzyme responsible for endocannabinoid hydrolysis, fatty acid amide hydrolase (FAAH), in RPE cell ..
  10. Lazary J, Lazary A, Gonda X, Benko A, Molnar E, Hunyady L, et al. Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:1118-27 pubmed publisher
    ..our study was to analyze the interaction of the promoter regions of the serotonin transporter (SLC6A4) and cannabinoid receptor 1 (CNR1) genes on anxiety...
  11. Jaeger J, Mattevi V, Callegari Jacques S, Hutz M. Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population. Dis Markers. 2008;25:67-74 pubmed
    ..Different studies have investigated the relationship between polymorphisms of the cannabinoid receptor 1 (CNR1) gene and obesity with conflicting results...
  12. Marshall A, Lagutina I, Grosveld G. PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis. Cancer Res. 2011;71:7471-80 pubmed publisher
    ..Here, we show that upregulation of the cannabinoid receptor 1 (Cnr1/Cb1) by PAX3-FOXO1 in mouse primary myoblasts and ARMS cell lines, contributes to PAX3-FOXO1 ..
  13. Chakrabarti B, Kent L, Suckling J, Bullmore E, Baron Cohen S. Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. Eur J Neurosci. 2006;23:1944-8 pubmed
    ..The cannabinoid receptor 1 (CNR1) is the best-characterized molecule of the endocannabinoid system, involved in processing rewards...
  14. Teixeira Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, Li L, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med. 2006;12:671-6 pubmed
    ..Here we investigated whether activation of cannabinoid CB1 receptors (encoded by Cnr1) promotes progression of fibrosis...
  15. Domschke K, Dannlowski U, Ohrmann P, Lawford B, Bauer J, Kugel H, et al. Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. Eur Neuropsychopharmacol. 2008;18:751-9 pubmed publisher
    ..Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 ..
  16. Ujike H, Takaki M, Nakata K, Tanaka Y, Takeda T, Kodama M, et al. CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia. Mol Psychiatry. 2002;7:515-8 pubmed
    ..examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-..
  17. Gazzerro P, Caruso M, Notarnicola M, Misciagna G, Guerra V, Laezza C, et al. Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population. Int J Obes (Lond). 2007;31:908-12 pubmed
    Endocannabinoids control food intake via both central and peripheral mechanisms, and cannabinoid type-1 receptor (CB1) modulates lipogenesis in primary adipocyte cell cultures and in animal models of obesity...
  18. Rozenfeld R, Devi L. Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J. 2008;22:2311-22 pubmed publisher
    b>Cannabinoid receptor 1 (CB(1)) is an abundant G protein-coupled receptor, involved in a number of physiological processes. This receptor is localized at the plasma membrane, as well as in intracellular vesicles...
  19. Bermudez Silva F, Suarez J, Baixeras E, Cobo N, Bautista D, Cuesta Munoz A, et al. Presence of functional cannabinoid receptors in human endocrine pancreas. Diabetologia. 2008;51:476-87 pubmed
    ..Human islets of Langerhans expressed CB1 and CB2 (also known as CNR1 and CNR2) mRNA and CB1 and CB2 proteins, and also the machinery involved in synthesis and degradation of 2-AG (the ..
  20. Schleinitz D, Carmienke S, Bottcher Y, Tonjes A, Berndt J, Kloting N, et al. Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity. Pharmacogenomics. 2010;11:693-702 pubmed publisher
    ..Here we investigated the effects of genetic variation in the cannabinoid type 1 receptor gene (CNR1) on its mRNA expression in adipose tissue from visceral and subcutaneous depots and on the development of obesity...
  21. Wu C, Zhu J, Wager Miller J, Wang S, O LEARY D, Monory K, et al. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci. 2010;32:693-706 pubmed publisher
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use. ..
  22. Murdolo G, Kempf K, Hammarstedt A, Herder C, Smith U, Jansson P. Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals. J Endocrinol Invest. 2007;30:RC17-21 pubmed
    ..We suggest that insulin may play a key role in the obesity-linked dysregulation of the adipose ES at the gene level. ..
  23. Galve Roperh I, Rueda D, Gómez del Pulgar T, Velasco G, Guzman M. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol. 2002;62:1385-92 pubmed
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision. ..
  24. Benzinou M, Chevre J, Ward K, Lecoeur C, Dina C, Lobbens S, et al. Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. Hum Mol Genet. 2008;17:1916-21 pubmed publisher
    ..Using a staged-approach, we examined the contribution of the endocannabinoid receptor 1 gene (CNR1) on obesity and body mass index (BMI) in the European population...
  25. Schmidt L, Samochowiec J, Finckh U, Fiszer Piosik E, Horodnicki J, Wendel B, et al. Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Drug Alcohol Depend. 2002;65:221-4 pubmed
    ..a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls...
  26. Zurolo E, Iyer A, Spliet W, van Rijen P, Troost D, Gorter J, et al. CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies. Neuroscience. 2010;170:28-41 pubmed publisher
    ..Using immunocytochemistry, we explored the expression and cellular pattern of CBR 1 and 2 (CB1 and CB2) during prenatal human cortical development, as well as in focal malformations of cortical development ..
  27. Silver H, Niswender K, Keil C, Jiang L, Feng Q, Chiu S, et al. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake. PLoS ONE. 2012;7:e36166 pubmed publisher
    ..We previously showed that a common CNR1 haplotype, H3 (frequency 20%), is protective against the reduction in HDL-C that typically accompanies weight gain...
  28. Hamdani N, Tabeze J, Ramoz N, Ades J, Hamon M, Sarfati Y, et al. The CNR1 gene as a pharmacogenetic factor for antipsychotics rather than a susceptibility gene for schizophrenia. Eur Neuropsychopharmacol. 2008;18:34-40 pubmed
    ..The possible role of a tag SNP (the 1359G/A polymorphism) of the gene encoding the cannabinoid receptor type 1 (CNR1) in schizophrenia and/or therapeutic response to atypical antipsychotics was assessed in a cohort of 133 French ..
  29. Feng Q, Jiang L, Berg R, Antonik M, MacKinney E, Gunnell Santoro J, et al. A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain. PLoS ONE. 2010;5:e15779 pubmed publisher
    We have previously shown that genetic variability in CNR1 is associated with low HDL dyslipidemia in a multigenerational obesity study cohort of Northern European descent (209 families, median ?=?10 individuals per pedigree)...
  30. Müller T, Reichwald K, Wermter A, Brönner G, Nguyen T, Friedel S, et al. No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. Mol Genet Metab. 2007;90:429-34 pubmed
    Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids...
  31. Heitland I, Klumpers F, Oosting R, Evers D, Leon Kenemans J, Baas J. Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1. Transl Psychiatry. 2012;2:e162 pubmed publisher
    ..cannabinoid system has a pivotal role in the successful extinction of fear, most importantly through the cannabinoid receptor 1. However, no human studies have reported a translation of this preclinical evidence yet...
  32. Zhang P, Ishiguro H, Ohtsuki T, Hess J, Carillo F, Walther D, et al. Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Mol Psychiatry. 2004;9:916-31 pubmed
    A number of lines of evidence make the gene that encodes the G-protein-coupled CB1/Cnr1 receptor a strong candidate to harbor variants that might contribute to individual differences in human addiction vulnerability...
  33. Park J, Choi M, Cho Y, Lee I, Kim S, Choi K, et al. Cannabinoid receptor 1 gene polymorphism and irritable bowel syndrome in the Korean population: a hypothesis-generating study. J Clin Gastroenterol. 2011;45:45-9 pubmed publisher
    ..We hypothesized that genetic variants of the cannabinoid receptor 1 gene (CNR1) might be associated with IBS...
  34. Sarfaraz S, Afaq F, Adhami V, Malik A, Mukhtar H. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem. 2006;281:39480-91 pubmed
    ..Based on these data we suggest that cannabinoid receptor agonists should be considered as novel agents for the management of prostate cancer. ..
  35. Gazzerro P, Malfitano A, Proto M, Santoro A, Pisanti S, Caruso M, et al. Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncol Rep. 2010;23:171-5 pubmed
    ..Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings. ..
  36. Nithipatikom K, Gomez Granados A, Tang A, Pfeiffer A, Williams C, Campbell W. Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. Endocrinology. 2012;153:29-41 pubmed publisher
    The cannabinoid receptor type 1 (CB1) is a G protein-coupled receptor that is activated in an autocrine fashion by the endocannabinoids (EC), N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG)...
  37. Porcella A, Maxia C, Gessa G, Pani L. The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. Eur J Neurosci. 2000;12:1123-7 pubmed
    ..polymerase chain reaction to detect the expression of the central and peripheral cannabinoid receptors (CB1 and CB2, respectively) mRNA, and Western blotting to show the presence of the CB1 protein in subregions of the ..
  38. Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle. Diabetologia. 2009;52:664-74 pubmed publisher
    Cannabinoid type 1 receptor (CB1R) antagonists such as rimonabant (Rim) represent a novel approach to treat obesity and related metabolic disorders. Recent data suggest that endocannabinoids are also produced by human adipocytes...
  39. Islam T, Asplund A, Lindvall J, Nygren L, Liden J, Kimby E, et al. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. Leukemia. 2003;17:1880-90 pubmed
    ..Of special interest was the high expression of the cannabinoid receptor 1 (CB1) gene in all MCL cases analysed...
  40. Caruso M, Gazzerro P, Notarnicola M, Cisternino A, Guerra V, Misciagna G, et al. Cannabinoid type 1 receptor gene polymorphism and macronutrient intake. J Nutrigenet Nutrigenomics. 2012;5:305-13 pubmed publisher
    Cannabinoid type 1 receptor (CB1-R) is a key mediator in the control of food intake and is linked to obesity. To evaluate the relationship between CB1-R gene polymorphism and dietary macronutrient intake in elderly subjects...
  41. Trabucco E, Acone G, Marenna A, Pierantoni R, Cacciola G, Chioccarelli T, et al. Endocannabinoid system in first trimester placenta: low FAAH and high CB1 expression characterize spontaneous miscarriage. Placenta. 2009;30:516-22 pubmed publisher
    ..2-AG) were the first endocannabinoids to be characterized, that bind two G protein-coupled receptors, CB1 and CB2...
  42. Leroy S, Griffon N, Bourdel M, Olie J, Poirier M, Krebs M. Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Am J Med Genet. 2001;105:749-52 pubmed
    ..Cannabinoid receptor (CB1) is particularly concentrated in dopamine-modulated areas of the nervous system...
  43. Storr M, Emmerdinger D, Diegelmann J, Pfennig S, Ochsenkuhn T, Goke B, et al. The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. PLoS ONE. 2010;5:e9453 pubmed publisher
    Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p...
  44. Xu X, Liu Y, Huang S, Liu G, Xie C, Zhou J, et al. Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma. Cancer Genet Cytogenet. 2006;171:31-8 pubmed
    b>CB1 and CB2 are multifunctional cannabinoid-specific receptors considered to be involved in inhibition of tumor development...
  45. Sarnataro D, Grimaldi C, Pisanti S, Gazzerro P, Laezza C, Zurzolo C, et al. Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells. FEBS Lett. 2005;579:6343-9 pubmed
    In this report we show, by confocal analysis of indirect immunofluorescence, that the type-1 cannabinoid receptor (CB1R), which belongs to the family of G-protein-coupled receptors, is expressed on the plasma membrane in human breast ..
  46. Chen X, Williamson V, An S, Hettema J, Aggen S, Neale M, et al. Cannabinoid receptor 1 gene association with nicotine dependence. Arch Gen Psychiatry. 2008;65:816-24 pubmed publisher
    The endogenous cannabinoid system has been implicated in drug addiction in animal models. The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain...
  47. Hoehe M, Caenazzo L, Martinez M, Hsieh W, Modi W, Gershon E, et al. Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15. New Biol. 1991;3:880-5 pubmed
    ..We have now determined the genomic location of the human cannabinoid receptor gene (CNR) by a combination of genetic linkage mapping and chromosomal in situ hybridization...
  48. Peeters A, Beckers S, Mertens I, Van Hul W, Van Gaal L. The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men. Endocrine. 2007;31:138-41 pubmed
    ..and lipogenesis via peripheral CB1 receptors, we hypothesized that genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity...
  49. Russo P, Strazzullo P, Cappuccio F, Tregouet D, Lauria F, Loguercio M, et al. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. J Clin Endocrinol Metab. 2007;92:2382-6 pubmed
    ..study was to determine whether single nucleotide polymorphisms of the gene encoding cannabinoid type 1 receptor, CNR1, are associated with body fat mass and distribution in two independent samples of white European adult men...
  50. Börner C, Hollt V, Sebald W, Kraus J. Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids. J Leukoc Biol. 2007;81:336-43 pubmed
    Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2...
  51. Fowler C, Hammarsten P, Bergh A. Tumour Cannabinoid CB(1) receptor and phosphorylated epidermal growth factor receptor expression are additive prognostic markers for prostate cancer. PLoS ONE. 2010;5:e15205 pubmed publisher
    ..These data indicate that a high tumour CB(1) receptor expression at diagnosis augments the deleterious effects of a high pEGFR expression upon disease-specific survival. ..
  52. Juhasz G, Chase D, Pegg E, Downey D, Toth Z, Stones K, et al. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms. Neuropsychopharmacology. 2009;34:2019-27 pubmed publisher
    b>Cannabinoid receptor 1 (CB1) gene (CNR1) knockout mice are prone to develop anhedonic and helpless behavior after chronic mild stress. In humans, the CB1 antagonist rimonabant increases the risk of depressed mood disorders and anxiety...
  53. Bedoya F, Rubio J, Morales Gutierrez C, Abad Barahona A, Lora Pablos D, Meneu J, et al. Single nucleotide change in the cannabinoid receptor-1 (CNR1) gene in colorectal cancer outcome. Oncology. 2009;76:435-41 pubmed publisher
    ..rejected specimens of human colorectal cancers and paired normal tissues were studied to detect mutations in the CNR1 gene by sequencing method...
  54. Gustafsson S, Palmqvist R, Henriksson M, Dahlin A, Edin S, Jacobsson S, et al. High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer. PLoS ONE. 2011;6:e23003 pubmed publisher
    ..A high CB(1)IR is indicative of a poorer prognosis in stage II microsatellite stable tumour patients. ..
  55. Mitjans M, Serretti A, Fabbri C, Gasto C, Catalan R, Fañanás L, et al. Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment. Psychopharmacology (Berl). 2013;227:509-19 pubmed publisher
    ..The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects...
  56. Lu A, Ogdie M, Jarvelin M, Moilanen I, Loo S, McCracken J, et al. Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1488-94 pubmed publisher
    ..The cannabinoid receptor gene (CNR1) is a positional candidate gene due to its location near an identified ADHD linkage peak on chromosome 6, its role ..
  57. Ehlers C, Slutske W, Lind P, Wilhelmsen K. Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians. Twin Res Hum Genet. 2007;10:805-11 pubmed publisher
    ..between the (AAT)n triplet repeat polymorphism as well as 5 single nucleotide polymorphisms (SNPs) in or near the CNR1 receptor gene and impulsivity in Southwest California 'Mission' Indians (SWC)...
  58. Hopfer C, Young S, Purcell S, Crowley T, Stallings M, Corley R, et al. Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:895-901 pubmed
    Cannabis is a major substance of abuse, and the gene encoding for the central cannabinoid receptor (CNR1) is a logical candidate gene for vulnerability toward developing symptoms of cannabis dependence...
  59. Rossi S, Buttari F, Studer V, Motta C, Gravina P, Castelli M, et al. The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis. Mult Scler. 2011;17:281-8 pubmed publisher
    ..To see whether CNR1 gene polymorphism could influence disease progression in relapsing-remitting MS...
  60. Mato S, Del Olmo E, Pazos A. Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain. Eur J Neurosci. 2003;17:1747-54 pubmed
    ..However, the pre- and postnatal pattern of appearance of CB1 cannabinoid receptors in humans has not been analysed in detail...
  61. Czifra G, Varga A, Nyeste K, Marincsák R, Toth B, Kovacs I, et al. Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J Cancer Res Clin Oncol. 2009;135:507-14 pubmed publisher
    Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular ..
  62. De Miguel Yanes J, Manning A, Shrader P, McAteer J, Goel A, Hamsten A, et al. Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. Obesity (Silver Spring). 2011;19:2031-7 pubmed publisher
    ..We analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2D) or coronary heart disease (CHD)...
  63. Baye T, Zhang Y, Smith E, Hillard C, Gunnell J, Myklebust J, et al. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics. 2008;9:1647-56 pubmed publisher
    ..In randomized trials, pharmacological blockade at the level of the cannabinoid receptor 1 (CNR1) receptor not only facilitates weight reduction, but also improves insulin sensitivity and clinical ..
  64. Thors L, Bergh A, Persson E, Hammarsten P, Stattin P, Egevad L, et al. Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4. PLoS ONE. 2010;5:e12275 pubmed publisher
    ..The correlation with CB(1)IR in the tumour tissue may be related to a common local dysregulation by a component of the tumour microenvironment. ..
  65. Lieb W, Manning A, Florez J, Dupuis J, Cupples L, McAteer J, et al. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring). 2009;17:755-60 pubmed publisher
    ..We hypothesize that common genetic variants in the CNR1 (encoding endocannabinoid receptor 1) and FAAH genes (encoding fatty acid amide hydrolase, a key enzyme hydrolyzing ..
  66. Filbey F, SCHACHT J, Myers U, Chavez R, Hutchison K. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology. 2010;35:967-75 pubmed publisher
    As previous work has highlighted the significance of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes with respect to cannabis dependence (CD), this study sought to characterize the neural mechanisms that ..
  67. Ramil E, Sanchez A, González Pérez P, Rodriguez Antiguedad A, Gómez Lozano N, Ortiz P, et al. The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain. Mult Scler. 2010;16:139-46 pubmed publisher
    ..The purpose of this study was to evaluate a possible association of MS with polymorphic markers at the CNR1 gene, encoding the cannabinoid 1 (CB(1)) receptor...
  68. Herman A, Kranzler H, Cubells J, Gelernter J, Covault J. Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:499-503 pubmed
    ..promoter producing a novel 5'-untranslated region of cannabinoid receptor mRNA has recently been described in CNR1, the gene encoding the cannabinoid receptor protein...
  69. Ruiz Llorente L, Sanchez M, Carmena M, Prieto J, Sanchez Chapado M, Izquierdo A, et al. Expression of functionally active cannabinoid receptor CB1 in the human prostate gland. Prostate. 2003;54:95-102 pubmed
    ..The cannabinoid receptor expressed in the prostate negatively regulates adenylyl cyclase activity through a pertussis toxin-sensitive protein. ..
  70. Bordicchia M, Battistoni I, Mancinelli L, Giannini E, Refi G, Minardi D, et al. Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans. Metabolism. 2010;59:734-41 pubmed publisher
    ..We studied perirenal VAT CB1 receptor expression in relation to anthropometry, VAT area and endocannabinoid levels, kidney microvascular damage (..