Gene Symbol: CNOT10
Description: CCR4-NOT transcription complex subunit 10
Alias: CCR4-NOT transcription complex subunit 10
Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007;27:4980-90 pubmed
..Thus, CCR4b may be involved in various cellular events that include cell proliferation. ..
Lau N, Kolkman A, van Schaik F, Mulder K, Pijnappel W, Heck A, et al
. Human Ccr4-Not complexes contain variable deadenylase subunits. Biochem J. 2009;422:443-53 pubmed publisher
..Taken together, human Ccr4-Not complexes are heterogeneous in composition owing to differences in their deadenylase subunits, which may reflect the multi-functionality of these complexes in cellular processes. ..
Miyasaka T, Morita M, Ito K, Suzuki T, Fukuda H, Takeda S, et al
. Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. Cancer Sci. 2008;99:755-61 pubmed publisher
..These results suggest that the antiproliferative activity of Tob is shown post-transcriptionally by controlling the stability of the target mRNAs in addition to its involvement in transcriptional regulation, reported previously. ..
Braun J, Huntzinger E, Fauser M, Izaurralde E. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell. 2011;44:120-33 pubmed publisher
Chekulaeva M, Mathys H, Zipprich J, Attig J, Colic M, Parker R, et al
. miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol. 2011;18:1218-26 pubmed publisher
Fabian M, Cieplak M, Frank F, Morita M, Green J, Srikumar T, et al
. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol. 2011;18:1211-7 pubmed publisher
..Thus, GW182 serves as both a platform that recruits deadenylases and as a deadenylase coactivator that facilitates the removal of the poly(A) tail by CCR4-NOT. ..
Weng N, Snyder J, Yu Lee L, Marcus D. Polymorphism of human immunoglobulin VH4 germ-line genes. Eur J Immunol. 1992;22:1075-82 pubmed
..Immunoglobulin gene polymorphism may make a significant contribution to hereditary variations in the immune response and to the genetic predisposition to autoimmune diseases. ..
Mauxion F, Preve B, Seraphin B. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. RNA Biol. 2013;10:267-76 pubmed publisher
..In addition, we show that CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the association of CNOT10 with the CCR4-NOT complex...
Bawankar P, Loh B, Wohlbold L, Schmidt S, Izaurralde E. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol. 2013;10:228-44 pubmed publisher
..Therefore, the recruitment of a single subunit of the complex to an mRNA target induces the assembly of the complete CCR4-NOT complex, resulting in a similar regulatory outcome. ..