Gene Symbol: CNBP
Description: CCHC-type zinc finger nucleic acid binding protein
Alias: CNBP1, DM2, PROMM, RNF163, ZCCHC22, ZNF9, cellular nucleic acid-binding protein, erythroid differentiation-related, sterol regulatory element-binding protein, zinc finger protein 273, zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
Species: human
Products:     CNBP

Top Publications

  1. Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, et al. Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2). Biochim Biophys Acta. 2006;1762:329-34 pubmed
    ..mutations: a (CTG)n expansion in 3' UTR region of the DMPK gene (DM1) and a (CCTG)n expansion in intron 1 of the ZNF9 gene (DM2). The most accredited mechanism for DM pathogenesis is an RNA gain-of-function...
  2. Sammons M, Antons A, Bendjennat M, Udd B, Krahe R, Link A. ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2. PLoS ONE. 2010;5:e9301 pubmed publisher
    ..DM2 is caused by an expansion of the tetranucleotide CCTG repeat within the first intron of ZNF9, although the mechanism by which the expanded nucleotide repeat causes the debilitating symptoms of DM2 is unclear...
  3. Rajavashisth T, Taylor A, Andalibi A, Svenson K, Lusis A. Identification of a zinc finger protein that binds to the sterol regulatory element. Science. 1989;245:640-3 pubmed
    ..We have designated the protein "cellular NBP" (CNBP)...
  4. Liquori C, Ricker K, Moseley M, Jacobsen J, Kress W, Naylor S, et al. Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. Science. 2001;293:864-7 pubmed
    ..form of muscular dystrophy in adults, can be caused by a mutation on either chromosome 19q13 (DM1) or 3q21 (DM2/PROMM)...
  5. Margolis J, Schoser B, Moseley M, Day J, Ranum L. DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression. Hum Mol Genet. 2006;15:1808-15 pubmed
    Myotonic dystrophy type 2 (DM2) is caused by a CCTG expansion mutation in intron 1 of the zinc finger protein 9 (ZNF9) gene...
  6. Gerbasi V, Link A. The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation. Mol Cell Proteomics. 2007;6:1049-58 pubmed
    ..The second protein, ZNF9 (myotonic dystrophy type 2 protein), has not been shown previously to bind IRES-like elements...
  7. Raheem O, Olufemi S, Bachinski L, Vihola A, Sirito M, Holmlund Hampf J, et al. Mutant (CCTG)n expansion causes abnormal expression of zinc finger protein 9 (ZNF9) in myotonic dystrophy type 2. Am J Pathol. 2010;177:3025-36 pubmed publisher
    ..that underlies myotonic dystrophy type 2 (DM2) is a (CCTG)n expansion in intron 1 of zinc finger protein 9 (ZNF9). It has been suggested that ZNF9 is of no consequence for disease pathogenesis...
  8. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
  9. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..related to gluconeogenesis [phosphoenolpyruvate carboxykinase (PEPCK); 13%], lipogenesis [sterol regulatory element binding protein 1 (SREBP1), acetyl-coenzyme A carboxylase (ACC), and fatty acid synthase (FASN); 46-90%], ..

More Information

Publications141 found, 100 shown here

  1. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..These data demonstrate that XB exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice. ..
  2. Valenzuela R, Echeverría F, Ortiz M, Rincón Cervera M, Espinosa A, Hernandez Rodas M, et al. Hydroxytyrosol prevents reduction in liver activity of ?-5 and ?-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. Lipids Health Dis. 2017;16:64 pubmed publisher
    ..HT supplementation prevents metabolic alterations in desaturase activities, oxidative stress status, and n-3 LCPUFA content in the liver and extrahepatic tissues of mice fed HFD. ..
  3. Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed publisher
    ..2% (P<0.05) and 60.9% (P<0.05) in mice fed with 5mg/kg and 20mg/kg HLF respectively. Sterol regulatory element binding protein-1c (SREBP-1c) was decreased by 59.3% in the group of 20mg/kg...
  4. Oishi K, Yamamoto S, Itoh N, Nakao R, Yasumoto Y, Tanaka K, et al. Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice. J Nutr. 2015;145:199-206 pubmed publisher
    ..4%, while upregulating the expression of hepatic cholesterol synthetic genes such as sterol regulatory element binding protein 2 (Srebf2) and 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1)...
  5. Veeramani C, Alsaif M, Al Numair K. Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. Biomed Pharmacother. 2017;96:1349-1357 pubmed publisher
    ..Taken together, we conclude that EFLC has a protective effect against HF diet induced hepatic lipid accumulation and oxidative cellular damage through the regulation of lipogenesis and lipolysis genes. ..
  6. Dong R, Yang X, Wang C, Liu K, Liu Z, Ma X, et al. Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. Phytomedicine. 2019;53:134-142 pubmed publisher
    ..Yangonin protects against NAFLD due to its activation of FXR signalling to inhibit hepatic lipogenesis and gluconeogenesis, and to promote lipid metabolism and glycogen synthesis, as well as insulin sensitivity. ..
  7. Nido S, Shituleni S, Mengistu B, Liu Y, Khan A, Gan F, et al. Effects of Selenium-Enriched Probiotics on Lipid Metabolism, Antioxidative Status, Histopathological Lesions, and Related Gene Expression in Mice Fed a High-Fat Diet. Biol Trace Elem Res. 2016;171:399-409 pubmed publisher
    ..Among the group, adding SP has a maximum effect in improving lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in mice fed a HFD. ..
  8. Lai K, Kweon S, Chi F, Hwang E, Kabe Y, Higashiyama R, et al. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017;152:1477-1491 pubmed publisher
    ..In rodent HSCs and TICs, the Wnt effector β-catenin increased sterol regulatory element binding protein 1-dependent transcription of Scd, and β-catenin in return was stabilized by MUFAs generated ..
  9. Lee M, Yang H, Park K, Ma J. Lycopus lucidus Turcz. ex Benth. Attenuates free fatty acid-induced steatosis in HepG2 cells and non-alcoholic fatty liver disease in high-fat diet-induced obese mice. Phytomedicine. 2019;55:14-22 pubmed publisher
    ..These results suggest that LLE may exert protective effects against NAFLD-related obesity and metabolic disease. ..
  10. He L, Hao L, Fu X, Huang M, Li R. Severe hypertriglyceridemia and hypercholesterolemia accelerating renal injury: a novel model of type 1 diabetic hamsters induced by short-term high-fat / high-cholesterol diet and low-dose streptozotocin. BMC Nephrol. 2015;16:51 pubmed publisher
    ..The mRNA levels of sterol regulatory element binding protein-1c, transforming growth factors-β, plasminogen activator inhibitor-1, tumor necrosis factor-Î..
  11. Hong M, Beidler J, Hooshmand S, Figueroa A, Kern M. Watermelon and l-arginine consumption improve serum lipid profile and reduce inflammation and oxidative stress by altering gene expression in rats fed an atherogenic diet. Nutr Res. 2018;58:46-54 pubmed publisher
    ..050). The results support the hypothesis that watermelon and arginine improve cardiovascular disease risk factors including lipid profile, antioxidant capacity, and inflammation by altering relevant gene expression. ..
  12. Wu N, Li R, Li L. SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway. Biochem Biophys Res Commun. 2018;501:343-350 pubmed publisher
    ..These results indicated that SOAT1 deficiency protected against atherosclerosis progression via inhibiting cholesterol transportation in ApoE-/- mice, which was, at least partly, dependent on HO-1 expressions. ..
  13. Shi H, Xu C, Liu M, Wang B, Liu W, Chen D, et al. Resveratrol Improves the Energy Sensing and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK-SIRT1-PGC-1α Network. Front Physiol. 2018;9:1258 pubmed publisher
    ..Furthermore, resveratrol improved glucose and insulin tolerance of fish fed the HC diet after glucose and insulin load. ..
  14. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..carboxylase alpha (ACCα) and malic enzyme (ME) and their related transcription factors sterol regulatory element binding protein 1/2 (SREBP-1 and 2)...
  15. Hwang K, Hwang Y, Kim G, Choe J. Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. BMC Complement Altern Med. 2015;15:347 pubmed publisher
    ..Additionally, AE extract decreased PI3K and Akt activity. Our results suggest that treatment with AE extract ameliorated NAFLD by inhibiting insulin resistance through activation of the Akt/GLUT4 pathway. ..
  16. Lim E, Lim J, Shin J, Seok P, Jung S, Yoo S, et al. D-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet-induced obese mice. Nutr Res. 2015;35:626-36 pubmed publisher
    ..In conclusion, our finding suggests that d-xylose may help prevent or attenuate the progression of obesity-related metabolic disorders by alleviating adipogenesis and dyslipidemia and improving lipid oxidation. ..
  17. Hsu J, Lin H, Hsu C, Chen B, Chen J. Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. Nutrients. 2018;10: pubmed publisher
    ..05). Our present study suggests that AEPL could protect the liver against ethanol-induced oxidative injury and lipid accumulation. ..
  18. Hong M, Hartig N, Kaufman K, Hooshmand S, Figueroa A, Kern M. Watermelon consumption improves inflammation and antioxidant capacity in rats fed an atherogenic diet. Nutr Res. 2015;35:251-8 pubmed publisher
    ..05). These findings indicate that watermelon improves risk factors for CVD in rats through better lipid profiles, lower inflammation, and greater antioxidant capacity by altering gene expression for lipid metabolism. ..
  19. Ren T, Zhu J, Zhu L, Cheng M. The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-?. Nutrients. 2017;9: pubmed publisher
    ..The levels of peroxisome proliferators-activated receptor (PPAR)-?, sterol regulatory element binding protein-1c (SREBP-1c), Patatin-like phospholipase domain-containing protein 3 (PNPLA-3), inflammatory ..
  20. Kim J, Kang E, Park M, Kim J, Kim S, Jeung E, et al. The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environ Toxicol Pharmacol. 2015;40:284-91 pubmed publisher
    ..transcription factors such as C/EBP-α (CAAT enhancer binding protein alpha) and SREBP-1c (sterol regulatory element binding protein-1c) were also reduced in both liver and adipose tissue...
  21. Naowaboot J, Wannasiri S, Pannangpetch P. Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice. J Physiol Biochem. 2016;72:269-80 pubmed publisher
    ..Interestingly, morin reduced expression of hepatic sterol regulatory element binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) and up-regulated ..
  22. Zhao Y, Li L, Ma J, Chen G, Bai J. LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2015;14:386-93 pubmed
    ..05). LXRalpha-RNAi-LV treatment significantly downregulated LXRalpha expression and improve steatotic liver graft function and recipient survival after a fatty liver transplantation in rats. ..
  23. Choi S, Lim J, Kim M, Kim E, Kim Y, Choi B, et al. Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy. Metabolism. 2018;85:348-360 pubmed publisher
    ..The reduction in oxidative stress and apoptosis by AdipoRon provides protection against renal damage, thereby ameliorating endothelial dysfunction in type 2 diabetic nephropathy. ..
  24. Ma K, Ruan X, Powis S, Chen Y, Moorhead J, Varghese Z. Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. Hepatology. 2008;48:770-81 pubmed publisher
    ..This inhibitory effect may cause cholesterol efflux reduction...
  25. Chen H, Tsai T, Tsai Y, Liao J, Yen C, Chen C. Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway. Nutr Diabetes. 2016;6:e237 pubmed publisher
    ..Therefore, kefir peptides may have the potential for clinical application for the prevention or treatment of clinical metabolic syndrome. ..
  26. Liu X, Hakucho A, Liu J, Fujimiya T. Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. World J Gastroenterol. 2014;20:18249-59 pubmed publisher
    ..gene expression level, the expression of lipid metabolism-associated enzyme regulator genes [sterol regulatory element binding protein (Srebp)-1 and peroxisome proliferator-activated receptor (Ppar)-α], the mediators that alter ..
  27. Ding L, Li J, Song B, Xiao X, Huang W, Zhang B, et al. Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway. J Pharmacol Exp Ther. 2014;351:474-83 pubmed publisher
    ..Andrographolide has potential as a leading compound in the prevention or treatment of obesity and insulin resistance. ..
  28. Liu J, Ma K, Zhang Y, Wu Y, Hu Z, Lv L, et al. Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease. Int J Biochem Cell Biol. 2015;61:8-19 pubmed publisher
    ..Our findings demonstrated that increased mTORC1 activity exacerbated the progression of NAFLD by disrupting LDLR expression via transcriptional and posttranscriptional mechanisms. ..
  29. Kim I, Choi J, Lee M, Kwon C, Nam T. Anti-obesity effects of pectinase and cellulase enzyme?treated Ecklonia cava extract in high?fat diet?fed C57BL/6N mice. Int J Mol Med. 2018;41:924-934 pubmed publisher
    ..Thus, EEc supplementation reduces HFD?induced obesity in C57BL/6N mice and has the potential to prevent obesity and subsequent metabolic disorders. ..
  30. Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, et al. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hepatology. 2006;44:602-11 pubmed
    ..Overexpression of the SREBP processing system contributed to the activation of LXRalpha by maintaining high oxysterol levels in tissue...
  31. Tavares C, Rassi C, Fahel M, Wajchenberg B, Rochitte C, Lerario A. Relationship between glycemic control and coronary artery disease severity, prevalence and plaque characteristics by computed tomography coronary angiography in asymptomatic type 2 diabetic patients. Int J Cardiovasc Imaging. 2016;32:1577-85 pubmed publisher
    Evaluate whether glycemic control in type 2 diabetes (DM2) asymptomatic for coronary artery disease (CAD) affects not only the presence and magnitude of CAD but also the characteristics of plaque vulnerability using multidetector row ..
  32. Dudek M, Kołodziejski P, Pruszyńska Oszmałek E, Ziarniak K, Sliwowska J. Effects of Orchidectomy and Testosterone Replacement on Numbers of Kisspeptin-, Neurokinin B-, and Dynorphin A-Immunoreactive Neurones in the Arcuate Nucleus of the Hypothalamus in Obese and Diabetic Rats. J Neuroendocrinol. 2017;29: pubmed publisher
    ..with high-fat diet-induced obesity (DIO) and/or streptozotocin-induced diabetes mellitus type 1 (DM1) and type 2 (DM2) will have alterations in numbers of immunoreactive (-IR) cells: kisspeptin-IR and/or neurokinin B-IR and dynorphin ..
  33. Heo J, Kim J, Dan Y, Kim Y, Kim J, Cho K, et al. Clusterin deficiency induces lipid accumulation and tissue damage in kidney. J Endocrinol. 2018;237:175-191 pubmed publisher
    ..Hence, clusterin may serve as a therapeutic target for lipid-induced chronic kidney disease. ..
  34. Hernández Anzaldo S, Berry E, Brglez V, Leung D, Yun T, Lee J, et al. Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver. J Am Heart Assoc. 2015;4: pubmed publisher
    ..was elevated, leading to hepatic inflammation, immune cell infiltration, dysregulation of the sterol regulatory element binding protein-2 and liver X receptor-α pathways, abnormal transcriptional responses to dietary cholesterol, ..
  35. Cho C, Park D, Lee S. Effect of C-terminal domain truncation of Thermus thermophilus trehalose synthase on its substrate specificity. Enzyme Microb Technol. 2017;96:121-126 pubmed publisher
    ..Compared with the wild-type (WT) enzyme, the two truncated enzymes (DM1 and DM2) showed lower maltose- and trehalose-converting activities and a different transglycosylation reaction mechanism...
  36. Shi H, Zhang C, Xu Z, Xu X, Lv Z, Luo J, et al. Nuclear receptor subfamily 1 group H member 2 (LXRB) is the predominant liver X receptor subtype regulating transcription of 2 major lipogenic genes in goat primary mammary epithelial cells. J Dairy Sci. 2017;100:6743-6752 pubmed publisher
    ..and LXRB in goat primary mammary epithelial cells to distinguish subtype-specific regulation of sterol regulatory element binding protein 1c (SREBP1c) and fatty acid synthase (FASN) mRNA expression and their promoter activity...
  37. Anwar S, Shikalgar N. Prevention of type 2 diabetes mellitus in polycystic ovary syndrome: A review. Diabetes Metab Syndr. 2017;11 Suppl 2:S913-S917 pubmed publisher
    ..sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan...
  38. Smolyannikova V, Alexandrova A. [Expression of epidermal growth factor receptor in patients with insulin resistance and seborrheic keratomas]. Arkh Patol. 2017;79:18-21 pubmed publisher
    ..factor receptor (EGFR) in patients with seborrheic keratomas (SK) and insulin resistance (type 2 diabetes mellitus (DM2)) and in those without concomitant carbohydrate metabolic disturbances. 80 patients with SK were examined...
  39. Laguna Hernández G, Rio Zamorano C, Meneses Ochoa I, Brechú Franco A. Histochemistry and immunolocalisation of glucokinin in antidiabetic plants used in traditional Mexican medicine. Eur J Histochem. 2017;61:2782 pubmed publisher
    ..DM is a chronic degenerative disease of energy metabolism that exists as two types: type 1 (DM1) and type 2 (DM2). DM is considered a public health problem that affects 7% of the Mexican population older than 20 years...
  40. Matsunaga H, Iwashita M, Shinjo T, Yamashita A, Tsuruta M, Nagasaka S, et al. Adipose tissue complement factor B promotes adipocyte maturation. Biochem Biophys Res Commun. 2018;495:740-748 pubmed publisher
    ..CfB plays a crucial role in late-phase of adipocyte differentiation and subsequent lipid droplet formation. ..
  41. Zhao Y, Pan Y, Yang Y, Batey R, Wang J, Li Y. Treatment of rats with Jiangzhi Capsule improves liquid fructose-induced fatty liver: modulation of hepatic expression of SREBP-1c and DGAT-2. J Transl Med. 2015;13:174 pubmed publisher
    ..Mechanistically, Jiangzhi Capsule downregulated fructose-stimulated hepatic overexpression of sterol regulatory element binding protein (SREBP)-1/1c at the mRNA and protein levels...
  42. Liu S, Zhang Y, Gao Y, Zhang L, Chen H, Zhou Q, et al. MiR-378 Plays an Important Role in the Differentiation of Bovine Preadipocytes. Cell Physiol Biochem. 2015;36:1552-62 pubmed
    ..MiR-378 promoted the differentiation of bovine preadipocytes. E2F2 and RANBP10 were the two target genes of miR-378, and might involve in the effects of miR-378 on the bovine preadipocyte differentiation. ..
  43. Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S. Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes. Toxicol Sci. 2017;155:432-443 pubmed publisher
    ..Taken together, we concluded that ligustrazine attenuated alcohol-induced hepatic steatosis via a Nrf2/HIF-1? pathway-dependent mechanism. ..
  44. Guo Q, Zhang C, Wang Y. Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes. Lipids Health Dis. 2017;16:105 pubmed publisher
    ..resulted in decreased protein levels of ER stress makers and lipogenic gene products, including sterol regulatory element binding protein 1, fatty acid synthase, and acetyl-CoA carboxylase 1...
  45. Samardzija D, Pogrmic Majkic K, Fa S, Stanic B, Jasnic J, Andric N. Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. Mol Cell Endocrinol. 2018;461:55-63 pubmed publisher
    ..decreased mRNA expression of ATP binding cassette transporter-A1 (Abca1) and increased level of sterol regulatory element binding protein 1...
  46. Catalli C, Morgante A, Iraci R, Rinaldi F, Botta A, Novelli G. Validation of sensitivity and specificity of tetraplet-primed PCR (TP-PCR) in the molecular diagnosis of myotonic dystrophy type 2 (DM2). J Mol Diagn. 2010;12:601-6 pubmed publisher
    ..OMIM #602688) is a multisystemic hereditary degenerative disease caused by a tetranucleotide CCTG expansion in the ZNF9 gene...
  47. Schreiber R, Hofer P, Taschler U, Voshol P, Rechberger G, Kotzbeck P, et al. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015;112:13850-5 pubmed publisher
    ..intake and altered signaling by peroxisome proliferator-activated receptor-gamma (PPAR-γ) and sterol regulatory element binding protein-1c in WAT accounted for the phenotype...
  48. Prodanović R, Korićanac G, Vujanac I, Djordjević A, Pantelić M, Romić S, et al. Obesity-driven prepartal hepatic lipid accumulation in dairy cows is associated with increased CD36 and SREBP-1 expression. Res Vet Sci. 2016;107:16-19 pubmed publisher
    ..These results suggest that increased expression of hepatic CD36 and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation. ..
  49. di Cagno A, Minganti C, Quaranta F, Pistone E, Fagnani F, Fiorilli G, et al. Effectiveness of a new cervical pillow on pain and sleep quality in recreational athletes with chronic mechanical neck pain: a preliminary comparative study. J Sports Med Phys Fitness. 2017;57:1154-1161 pubmed publisher
    ..05) after the use of the DM2 pillow than the own pillow...
  50. Xiao R, Hao J, Ding Y, Che Y, Zou X, Liang B. Transcriptome Profile Reveals that Pu-Erh Tea Represses the Expression of Vitellogenin Family to Reduce Fat Accumulation in Caenorhabditis elegans. Molecules. 2016;21: pubmed
    ..lowers the fat accumulation primarily through repression of the expression of vit(vitellogenin) family, in addition to our previously reported (sterol regulatory element binding protein) SREBP-SCD (stearoyl-CoA desaturase) axis.
  51. Sanchez Santos R, Corcelles R, Vilallonga Puy R, Delgado Rivilla S, Ferrer J, Foncillas Corvinos J, et al. Prognostic factors of weight loss after sleeve gastrectomy: Multi centre study in Spain and Portugal. Cir Esp. 2017;95:135-142 pubmed publisher
    ..with influence on the weight loss failure in univariate analysis were: BMI>50kg/m2, age>50years, DM2, hypertension, OSA, heart disease, multiple comorbidities, distance to pylorus> 4cm, bougie>40F, treatment ..
  52. Baumgartner S, Mensink R, Haenen G, Bast A, Binder C, Bekers O, et al. The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Sci Rep. 2017;7:15288 pubmed publisher
    ..Twenty subjects with impaired glucose tolerance (IGT) or type 2 diabetes (DM2) consumed for 4 weeks placebo, vitamin E (804?mg/d) or lipoic acid capsules (600?mg/d)...
  53. Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X, et al. Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Biomed Pharmacother. 2017;: pubmed publisher
    ..the phosphorylation of AMP-activated protein kinase (AMPK) and down-regulated the levels of sterol regulatory element binding protein-1 (SREBP-1) and sterol regulatory element binding protein-2 (SREBP-2) in 1,3-DCP-induced HepG2 ..
  54. Lee M, Park K, Ma J. Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. Nutrients. 2017;10: pubmed publisher
    ..Moreover, LJE significantly reduced the expression of sterol regulatory element binding protein 1-c, and its downstream genes, which are associated with lipogenesis, in HepG2 cells...
  55. Schmitz G, Langmann T. Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochim Biophys Acta. 2005;1735:1-19 pubmed
    ..Thus, a highly sophisticated transcriptional network controls the balanced expression of ABCA1...
  56. Wu Q, Liu Q. HBx truncation mutants differentially modulate SREBP-1a and -1c transcription and HBV replication. Virus Res. 2015;210:46-53 pubmed publisher
    ..Our results should help understand the interactions between HBV and the SREBP-1-mediated lipogenic pathway. ..
  57. Burr R, Stewart E, Shao W, Zhao S, Hannibal Bach H, Ejsing C, et al. Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast. J Biol Chem. 2016;291:12171-83 pubmed publisher
    ..Together, these results establish Mga2 as a transcriptional regulator of triacylglycerol and glycerophospholipid homeostasis in S. pombe, analogous to mammalian SREBP-1. ..
  58. Montoya Rosales A, Castro Garcia P, Torres Juarez F, Enciso Moreno J, Rivas Santiago B. Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control. Microb Pathog. 2016;97:148-53 pubmed publisher
    ..Further evaluation for LL-37 needs to be done to determine whether this peptide can be used as a biomarker of tuberculosis progression in DM2 patients.
  59. Kim D, Lee S, Jun H. Impact of T-cell-specific Smad4 deficiency on the development of autoimmune diabetes in NOD mice. Immunol Cell Biol. 2017;95:287-296 pubmed publisher
    ..T cells from Smad4 tKO was significantly elevated compared with WT NOD mice, and activation of sterol regulatory element binding protein-1c (SREBP-1c) in T cells of Smad4 tKO NOD mice was correlated with this proliferative activity...
  60. Kardas P, Lewandowski K, Bromuri S. Type 2 Diabetes Patients Benefit from the COMODITY12 mHealth System: Results of a Randomised Trial. J Med Syst. 2016;40:259 pubmed
    ..This was a prospective parallel-arm randomized controlled trial in outpatients diagnosed with DM2, being treated in the primary care settings in Lodz region, Poland, with 6 weeks period of follow-up...
  61. Zhang D, Tong X, VanDommelen K, Gupta N, Stamper K, Brady G, et al. Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J Clin Invest. 2017;127:2855-2867 pubmed publisher
    ..Our findings also identified a role for ChREBP in regulating SREBP2-dependent cholesterol metabolism. ..
  62. Coenen M, Tieleman A, Schijvenaars M, Leferink M, Ranum L, Scheffer H, et al. Dutch myotonic dystrophy type 2 patients and a North-African DM2 family carry the common European founder haplotype. Eur J Hum Genet. 2011;19:567-70 pubmed publisher
    ..The disease is caused by a repeat expansion in the zinc-finger protein 9 (ZNF9) gene on chromosome 3q21...
  63. Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, et al. HNF4? increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion. Arterioscler Thromb Vasc Biol. 2012;32:1005-14 pubmed publisher
    ..However, the regulatory element is not conserved in humans. Here we investigated the mechanism of sterol-regulated human hepatic ABCA1 gene expression...
  64. Chen J, Li H, An N, Li S, Lu W, Xing H, et al. [Effect of TBLR1-RARα Fusion Gene on Erythroid Differentiation of K562 Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1702-8 pubmed publisher
    ..The expression of TBLR1-RARα fusion gene contribute to ATRA-inducing differentiation of K562 cells into erythroid lineage. ..
  65. Sharawy M, El Awady M, Megahed N, Gameil N. The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. Can J Physiol Pharmacol. 2016;94:488-97 pubmed publisher
    ..Additionally, HMB enhanced ACh-induced relaxation, ameliorated hepatic steatosis, and decreased mRNA expression of GLUT-2. In conclusion, HMB may attenuate insulin resistance and hepatic steatosis through inhibiting GLUT-2 in liver. ..
  66. Stuttmann J, Peine N, García A, Wagner C, Choudhury S, Wang Y, et al. Arabidopsis thaliana DM2h (R8) within the Landsberg RPP1-like Resistance Locus Underlies Three Different Cases of EDS1-Conditioned Autoimmunity. PLoS Genet. 2016;12:e1005990 pubmed publisher
    ..thaliana accession Landsberg erecta (Ler). The DM2 locus is a known hotspot for deleterious epistatic interactions leading to immune-related incompatibilities between ..
  67. Millán Núñez Cortés J, de la Figuera von Wichmann M, Rodríguez de Miguel M, Orera Peña M, Labrador Barba E, Lería Gelabert M. [Management of hypertension and diabetes in Primary Care clinical practice: ATENCION study]. Semergen. 2017;43:196-206 pubmed publisher
    ..therapeutic decisions of Primary Care (PC) physicians when treating hypertension (HT) and diabetes mellitus type 2 (DM2), with the aim of establishing the situation and eventually proposing improvement strategies...
  68. Sim S, Chin S, Tan J, Brown S, Cussons A, Stuckey B. Polycystic ovary syndrome in type 2 diabetes: does it predict a more severe phenotype?. Fertil Steril. 2016;106:1258-1263 pubmed publisher
    To examine the prevalence of a history of polycystic ovary syndrome (PCOS) in women with type 2 diabetes (DM2) and to compare metabolic and reproductive outcomes between women with and without PCOS. Cross-sectional study...
  69. Barami K, Lyon L, Conell C. Type 2 Diabetes Mellitus and Glioblastoma Multiforme-Assessing Risk and Survival: Results of a Large Retrospective Study and Systematic Review of the Literature. World Neurosurg. 2017;106:300-307 pubmed publisher
    Despite studies showing a positive correlation between type 2 diabetes mellitus (DM2), a modifiable risk factor, and various cancer types, the link remains controversial in the setting of glioblastoma multiforme (GBM)...
  70. Qin W, Zhang X, Yang L, Xu L, Zhang Z, Wu J, et al. Microcystin-LR altered mRNA and protein expression of endoplasmic reticulum stress signaling molecules related to hepatic lipid metabolism abnormalities in mice. Environ Toxicol Pharmacol. 2015;40:114-21 pubmed publisher
    ..of downstream factors and genes of ER stress signaling pathways, including the downregulation of sterol regulatory element binding protein 1c (SREBP-1c) and fatty acid synthase (FASn), and upregulation of acetyl-coenzyme A carboxylase ..
  71. Li Y, Li R, Chen W, Chen G. Vitamin A status and its metabolism contribute to the regulation of hepatic genes during the cycle of fasting and refeeding in rats. J Nutr Biochem. 2016;30:33-43 pubmed publisher
    ..We conclude that VA status and its metabolism in the fasting and refeeding cycle contribute to the regulation of hepatic gene expression in rats. ..
  72. Shipp S, Cline M, Gilbert E. Promotion of adipogenesis by neuropeptide Y during the later stages of chicken preadipocyte differentiation. Physiol Rep. 2016;4: pubmed
  73. Perez Campo F, De Castro Orós I, Noriega A, Cofan M, Lamiquiz Moneo I, Cenarro A, et al. Functional analysis of new 3' untranslated regions genetic variants in genes associated with genetic hypercholesterolemias. J Clin Lipidol. 2017;11:532-542 pubmed publisher
    ..Our findings reveal novel regulatory links between certain miRNAs and key genes regulating cholesterol homeostasis. They also highlight the potential of miRNAs as therapeutic targets for the treatment of FH. ..
  74. Takahashi K, Yanai S, Shimokado K, Ishigami A. Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels. Nutrition. 2017;38:1-8 pubmed publisher
    ..Moreover, coffee consumption by the aged population had a positive effect on behavioral energy and lipid metabolism. ..
  75. Santos I, de Bem G, Cordeiro V, da Costa C, de Carvalho L, da Rocha A, et al. Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice. Nutr Res. 2017;43:69-81 pubmed publisher
    ..The regulation of hepatic insulin signaling pathway, lipogenesis, and oxidative stress may contribute to ACH09's protective effect. ..
  76. Lee J, Jeon Y, Lee K, Lee H, Park J, Jang H, et al. RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer. Mol Cell Biol. 2017;37: pubmed publisher
    ..In ccRCC patients, RNF20 downregulation and SREBP1 activation are markers of poor prognosis. Therefore, RNF20 suppresses tumorigenesis in ccRCC by inhibiting the SREBP1c-PTTG1 axis. ..
  77. Gilis Januszewska A, Piwońska Solska B, Lindström J, Wójtowicz E, Tuomilehto J, Schwarz P, et al. Determinants of weight outcomes in type 2 diabetes prevention intervention in primary health care setting (the DE-PLAN project). BMC Public Health. 2018;18:97 pubmed publisher
    ..performed in different settings have proved that lifestyle interventions in the prevention of type 2 diabetes (DM2) can be effective, although the weight reduction results are typically modest compared to randomized control trials...
  78. Li Y, Bolten C, Bhat B, Woodring Dietz J, Li S, Prayaga S, et al. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol. 2002;16:506-14 pubmed
    ..This would lead to increased hLXRalpha levels and transcription of its downstream target genes such as ABCA1, providing a simple yet exquisite mechanism for cells to respond to LXR ligands and cholesterol loading...
  79. Abildayeva K, Jansen P, Hirsch Reinshagen V, Bloks V, Bakker A, Ramaekers F, et al. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem. 2006;281:12799-808 pubmed
    ..In conclusion, evidence is provided that 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway, which may be relevant for chronic and acute neurological diseases...
  80. Wong J, Quinn C, Brown A. SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. Biochem J. 2006;400:485-91 pubmed
    ..In addition, our results indicate a critical role of SREBP-2 as a positive regulator of ABCA1 gene expression by enabling the generation of oxysterol ligands for LXR...
  81. Chang H, Hu H, Lee Y, Wei H, Fan June M, Hsu T, et al. Proteomic analyses and identification of arginine methylated proteins differentially recognized by autosera from anti-Sm positive SLE patients. J Biomed Sci. 2013;20:27 pubmed publisher
    ..proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences...
  82. Hoang M, Jia Y, Mok B, Jun H, Hwang K, Lee S. Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-β. J Nutr Biochem. 2015;26:868-75 pubmed publisher
    ..They also suggest that kaempferol activates LXR-β and suppresses SREBP-1 to enhance symptoms in metabolic syndrome. ..
  83. Tian J, Goldstein J, Brown M. Insulin induction of SREBP-1c in rodent liver requires LXR?-C/EBP? complex. Proc Natl Acad Sci U S A. 2016;113:8182-7 pubmed publisher
    ..The LXR?-C/EBP? complex is bound to the SREBP-1c promoter in the absence or presence of insulin, indicating that insulin acts not by increasing the formation of this complex, but rather by activating it. ..
  84. Bae J, Oh A, Lee H, Ahn Y, Cha J. Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c. Biochem Biophys Res Commun. 2016;478:1060-6 pubmed publisher
    ..Mouse Elovl6 has been shown to be a direct target of sterol regulatory element binding protein-1 (SREBP-1) in response to insulin...
  85. Xue Z, Hennelly S, Doyle B, Gulati A, Novikova I, Sanbonmatsu K, et al. A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage. Mol Cell. 2016;64:37-50 pubmed publisher
    ..We demonstrate a specific interaction between AGIL and cellular nucleic acid binding protein (CNBP/ZNF9), a zinc-finger protein known to bind single-stranded G-rich sequences...
  86. Sekar S, Omran E, Gopalakrishnan V, Howland J, Snutch T, Taghibiglou C. Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg. Epilepsy Res. 2017;136:1-4 pubmed publisher
    Studies in animal models and human tissues show that nuclear translocation of sterol regulatory element binding protein 1 (SREBP1) and glutamate A2 subunit (GluA2) of cell-surface AMPA receptor (AMPAR) trigger neuronal excitotoxicity-..
  87. Jang J, Jung Y, Chae S, Cho S, Yoon M, Yang H, et al. Gangjihwan, a polyherbal composition, inhibits fat accumulation through the modulation of lipogenic transcription factors SREBP1C, PPAR? and C/EBP?. J Ethnopharmacol. 2018;210:10-22 pubmed publisher
    ..DF was found to down-regulate the expressions of the lipogenic transcription factors such as sterol regulatory element binding protein 1C (SREBP1C), peroxisome proliferator activated receptor gamma (PPAR?), and CCAAT/enhancer ..
  88. Yang Y, Yang Q, Yang J, Ma Y, Ding G. Angiotensin II induces cholesterol accumulation and injury in podocytes. Sci Rep. 2017;7:10672 pubmed publisher
  89. Montagnese F, Mondello S, Wenninger S, Kress W, Schoser B. Assessing the influence of age and gender on the phenotype of myotonic dystrophy type 2. J Neurol. 2017;264:2472-2480 pubmed publisher
    This study aims to provide a detailed clinical characterization of a large cohort of myotonic dystrophy type 2 (DM2) patients investigating the influence of age and gender as modifying factors of DM2 phenotype...
  90. Mejia Martinez F, Franco Juarez B, Moreno Arriola E, Hernández Vázquez A, Martinez Avila M, Gómez Manzo S, et al. The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans. Genes (Basel). 2017;8: pubmed publisher
    ..This study also suggests that inhibition of MXL-3 may serve as a potential target for the treatment of chronic metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disease. ..
  91. Yunusova N, Kondakova I, Kolomiets L, Afanas ev S, Chernyshova A, Kudryavtsev I, et al. Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). Asia Pac J Clin Oncol. 2017;: pubmed publisher
  92. Flink I, Morkin E. Organization of the gene encoding cellular nucleic acid-binding protein. Gene. 1995;163:279-82 pubmed
    The human cellular CNBP gene locus has been sequenced and is comprised of 6453 bp from the transcription start point (tsp) to the polyadenylation signal, and an additional 201 bp of 5' and 259 bp of 3' flanking sequences...