Gene Symbol: CNAP1
Description: non-SMC condensin I complex subunit D2
Alias: CAP-D2, CNAP1, hCAP-D2, condensin complex subunit 1, XCAP-D2 homolog, chromosome condensation-related SMC-associated protein 1, chromosome-associated protein D2
Species: human
Products:     CNAP1

Top Publications

  1. Ball A, Schmiesing J, Zhou C, Gregson H, Okada Y, Doi T, et al. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Mol Cell Biol. 2002;22:5769-81 pubmed
    b>CNAP1 (hCAP-D2/Eg7) is an essential component of the human condensin complex required for mitotic chromosome condensation...
  2. Schmiesing J, Gregson H, Zhou S, Yokomori K. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Mol Cell Biol. 2000;20:6996-7006 pubmed
    ..identified a 155-kDa protein interacting with hCAP-C-hCAP-E, termed condensation-related SMC-associated protein 1 (CNAP1)...
  3. Heale J, Ball A, Schmiesing J, Kim J, Kong X, Zhou S, et al. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell. 2006;21:837-48 pubmed
    ..Furthermore, depletion of condensin in vivo compromises SSB but not double-strand break (DSB) repair. Our results identify a SSB-specific response of condensin I through PARP-1 and demonstrate a role for condensin in SSB repair. ..
  4. Ono T, Losada A, Hirano M, Myers M, Neuwald A, Hirano T. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 2003;115:109-21 pubmed
    ..We propose that the two condensin complexes make distinct mechanistic contributions to mitotic chromosome architecture in vertebrate cells. ..
  5. Solar P, Sytkowski A. Differentially expressed genes associated with cisplatin resistance in human ovarian adenocarcinoma cell line A2780. Cancer Lett. 2011;309:11-8 pubmed publisher
    ..processes, such as inhibition of apoptosis (ARHGDIB), stress response (HSPCA, TRA1), chromatin condensation (CNAP1, RanBP2), invasiveness of cells (MMP10), alteration of Ca(2+) homeostasis (ASPH, ATP2B1) and others...
  6. Hara K, Kinoshita K, Migita T, Murakami K, Shimizu K, Takeuchi K, et al. Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. EMBO Rep. 2019;: pubmed publisher
  7. Beck E, Llopart A. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Sci Rep. 2015;5:17197 pubmed publisher
  8. Martin C, Murray J, Carroll P, Leitch A, Mackenzie K, Halachev M, et al. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Genes Dev. 2016;30:2158-2172 pubmed
  9. Li W, Hu Y, Oh S, Ma Q, Merkurjev D, Song X, et al. Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation. Mol Cell. 2015;59:188-202 pubmed publisher
    ..Collectively, our results reveal an important, unanticipated transcriptional role of interphase condensins in modulating estrogen-regulated enhancer activation and coding gene transcriptional program. ..

More Information


  1. Zhang P, Liu L, Huang J, Shao L, Wang H, Xiong N, et al. Non-SMC condensin I complex, subunit D2 gene polymorphisms are associated with Parkinson's disease: a Han Chinese study. Genome. 2014;57:253-7 pubmed publisher
    ..044, respectively). This research demonstrates a positive relationship between the NCAPD2 gene and the risk for Parkinson's disease in a Han Chinese population and provides a potential genetic marker for sporadic Parkinson's disease. ..
  2. Simon M. Racial, ethnic, and gender diversity and the resident operative experience. How can the Academic Orthopaedic Society shape the future of orthopaedic surgery?. Clin Orthop Relat Res. 1999;:253-9 pubmed
  3. Kong X, Stephens J, Ball A, Heale J, Newkirk D, Berns M, et al. Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. PLoS ONE. 2011;6:e23548 pubmed publisher
    ..We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I. ..
  4. Lee J, Cheng R, Rogaeva E, Meng Y, Stern Y, Santana V, et al. Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. Neurogenetics. 2008;9:127-38 pubmed publisher
    ..Taken together, these SNPs may be in linkage disequilibrium with a pathogenic variant(s) on or near NCAPD2 and GAPDH. ..
  5. Kimura K, Cuvier O, Hirano T. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 2001;276:5417-20 pubmed
    ..polypeptide (hCAP)-C and hCAP-E) subunits and three non-structural maintenance of chromosomes (hCAP-D2/CNAP1, hCAP-G, and hCAP-H/BRRN) subunits...
  6. Onn I, Aono N, Hirano M, Hirano T. Reconstitution and subunit geometry of human condensin complexes. EMBO J. 2007;26:1024-34 pubmed
    ..Cleavage pattern of SMC2 by limited proteolysis is changed upon its binding to ATP or DNA. Our results shed new light on the architecture and dynamics of this highly elaborate machinery designed for chromosome assembly. ..
  7. Navarro Domínguez B, Ruiz Ruano F, Camacho J, Cabrero J, López León M. Transcription of a B chromosome CAP-G pseudogene does not influence normal Condensin Complex genes in a grasshopper. Sci Rep. 2017;7:17650 pubmed publisher
  8. Wike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5:e11402 pubmed publisher
    ..We propose that H3 T118ph alters the chromatin structure during specific phases of mitosis to promote timely condensin I and cohesin disassociation, which is essential for effective chromosome segregation. ..
  9. Collas P, Le Guellec K, Tasken K. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. J Cell Biol. 1999;147:1167-80 pubmed
    ..We propose that AKAP95 is a multivalent molecule that in addition to anchoring a cAMP/PKA-signaling complex onto chromosomes, plays a role in regulating chromosome structure at mitosis. ..