Gene Symbol: CMTM7
Description: CKLF like MARVEL transmembrane domain containing 7
Alias: CKLFSF7, CKLF-like MARVEL transmembrane domain-containing protein 7, chemokine-like factor super family 7, chemokine-like factor super family member 7 variant 2, chemokine-like factor superfamily 7, chemokine-like factor superfamily member 7
Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al
. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
..The characteristics of CKLFSF2-7 are intermediate between CKLFSF1 and CKLFSF8. This indicates that CKLFSF represents a novel gene family between the SCY and the TM4SF gene families. ..
Jin Y, Qin X, Jia G. SOX10-dependent CMTM7 expression inhibits cell proliferation and tumor growth in gastric carcinoma. Biochem Biophys Res Commun. 2018;507:91-99 pubmed publisher
..b>CMTM7 has also been reported to be down-regulated in some digestive system tumors, but the expression patterns and ..
Liu B, Su Y, Li T, Yuan W, Mo X, Li H, et al
. CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation. Oncotarget. 2015;6:41092-107 pubmed publisher
..Our previous study on CMTM7 is only limited to a brief description of the relationship of overexpressed CMTM7 with EGFR-AKT signaling...
Morrison A, Felix J, Cupples L, Glazer N, Loehr L, Dehghan A, et al
. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet. 2010;3:248-55 pubmed publisher
..significant locus on chromosome 3p22 in an intron of CKLF-like MARVEL transmembrane domain containing 7 (CMTM7, P=3.2x10(-7))...
Liu Q, Su Y, Jiang G, Zhou Z, Liu B, Bu L, et al
. Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer. Chin Med J (Engl). 2013;126:3006-12 pubmed
CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) located at 3p22.3, is a frequent deletion site and a tumor suppressor gene (TSG) locus in many cancer, which suggests CMTM7 may be a potential TSG...
Miyazaki A, Yogosawa S, Murakami A, Kitamura D. Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor. PLoS ONE. 2012;7:e31829 pubmed publisher
..Here we show that CMTM7, a tetra-spanning membrane protein of unknown function, co-localized with clathrin and sIgM at the plasma membrane...
Li H, Li J, Su Y, Fan Y, Guo X, Li L, et al
. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth. Oncogene. 2014;33:3109-18 pubmed publisher
..We studied a novel candidate TSG, CMTM7, located at the 3p22.3 CMTM-gene cluster, for its tumor-suppressive functions and related mechanisms...