Gene Symbol: CMTM6
Description: CKLF like MARVEL transmembrane domain containing 6
Alias: CKLFSF6, PRO2219, CKLF-like MARVEL transmembrane domain-containing protein 6, chemokine-like factor super family 6, chemokine-like factor superfamily 6, chemokine-like factor superfamily member 6
Domschke G, Linden F, Pawig L, Hafner A, Akhavanpoor M, Reymann J, et al
. Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation. Sci Rep. 2018;8:10516 pubmed publisher
..Silencing of four novel genes (APOC1, CMTM6, FABP4, WBP5) reduced macrophage LDL-uptake...
Guan X, Zhang C, Zhao J, Sun G, Song Q, Jia W. CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas. EBioMedicine. 2018;35:233-243 pubmed publisher
b>CMTM6, a previously uncharacterized protein, was identified as a critical regulator of PD-L1, which is reported as an immune checkpoint inhibitor, to modulate the T cell activities both in vitro and in vivo of other tumors...
Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al
. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
..The characteristics of CKLFSF2-7 are intermediate between CKLFSF1 and CKLFSF8. This indicates that CKLFSF represents a novel gene family between the SCY and the TM4SF gene families. ..
Mezzadra R, Sun C, Jae L, Gomez Eerland R, de Vries E, Wu W, et al
. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017;549:106-110 pubmed publisher
..Here we identify, using a haploid genetic screen, CMTM6, a type-3 transmembrane protein of previously unknown function, as a regulator of the PD-L1 protein...
Burr M, Sparbier C, Chan Y, Williamson J, Woods K, Beavis P, et al
. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature. 2017;549:101-105 pubmed publisher
..Here we identify the uncharacterized protein CMTM6 as a critical regulator of PD-L1 in a broad range of cancer cells, by using a genome-wide CRISPR-Cas9 screen...
Griffin G. A recycling program that keeps PD-L1 out of the cancer cell's junkyard. Sci Immunol. 2017;2: pubmed publisher
b>CMTM6 limits antitumor immunity by ensuring efficient recycling of endocytosed PD-L1 protein.