Gene Symbol: CMTM4
Description: CKLF like MARVEL transmembrane domain containing 4
Alias: CKLFSF4, CKLF-like MARVEL transmembrane domain-containing protein 4, chemokine-like factor super family 4, chemokine-like factor superfamily member 4
Liu F, Liu X, Liu X, Li T, Zhu P, Liu Z, et al
. Integrated analyses of phenotype and quantitative proteome of CMTM4 deficient mice reveal its association with male fertility. Mol Cell Proteomics. 2019;: pubmed publisher
..b>CMTM4 is an evolutionarily conserved member that is highly expressed in the testis...
Chrifi I, Louzao Martinez L, Brandt M, van Dijk C, Bürgisser P, Zhu C, et al
. CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions. Angiogenesis. 2019;22:75-93 pubmed publisher
..Here, we evaluated the angiogenic potential of (CKLF-like MARVEL transmembrane domain 4) CMTM4 and assessed in which molecular pathway CMTM4 is involved during angiogenesis...
Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al
. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
..The characteristics of CKLFSF2-7 are intermediate between CKLFSF1 and CKLFSF8. This indicates that CKLFSF represents a novel gene family between the SCY and the TM4SF gene families. ..
Plate M, Li T, Wang Y, Mo X, Zhang Y, Ma D, et al
. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. Mol Cells. 2010;29:355-61 pubmed publisher
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 ..
Li T, Cheng Y, Wang P, Wang W, Hu F, Mo X, et al
. CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. J Exp Clin Cancer Res. 2015;34:122 pubmed publisher
..b>CMTM4 is a member of this family and is located at chromosome 16q22...
Mezzadra R, Sun C, Jae L, Gomez Eerland R, de Vries E, Wu W, et al
. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017;549:106-110 pubmed publisher
..and genetic complementation experiments, we demonstrate that this function is shared by its closest family member, CMTM4, but not by any of the other CMTM members tested...
Bei C, Zhang Y, Wei R, Zhu X, Wang Z, Zeng W, et al
. Clinical significance of CMTM4 expression in hepatocellular carcinoma. Onco Targets Ther. 2017;10:5439-5443 pubmed publisher
b>CMTM4 is the most conserved member of chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family on chromosome 16q22.1, a locus that harbors a number of tumor-suppressor genes...