Genomes and Genes
Gene Symbol: CLEC4M
Description: C-type lectin domain family 4 member M
Alias: CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, CD299 antigen, DC-SIGN-related protein, dendritic cell-specific ICAM-3-grabbing non-integrin 2, liver/lymph node-specific ICAM-3 grabbing non-integrin, mannose binding C-type lectin DC-SIGNR
Publications146 found, 100 shown here
- Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmissionRonaldo Celerino da Silva
Department of Genetics, Federal University of Pernambuco, Cidade Universitaria, Recife, PE, Brazil
Hum Immunol 72:305-11. 2011..This review aims to explore the involvement of the DC-SIGN and L-SIGN receptors in HIV-1 transmission from mother to child...
- Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infectionVarsha Srivastava
Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
J Biol Chem 284:25532-41. 2009..tb. These results indicate that TLR2 and DC-SIGNR1 differentially regulate SOCS1 expression during M. tb infection. This in turn regulates M. tb survival by governing key cytokine expression...
- HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)Nancy P Y Chung
HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
J Biol Chem 285:2100-12. 2010..These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity...
- Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120B M Curtis
Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121
Proc Natl Acad Sci U S A 89:8356-60. 1992..Collectively, these data demonstrate that the gp120-binding protein is a membrane-associated mannose-binding lectin. Proteins of this type may play an important role in the CD4-independent association of HIV with cells...
- Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)L Gattegno
Laboratoire de Biologie Cellulaire, Faculté de Médecine Paris Nord, Bobigny, France
AIDS Res Hum Retroviruses 8:27-37. 1992..These findings obtained with plant lectins may be of relevance in vivo, inasmuch as endogenous mannosyl-binding proteins, which are known to function as opsonins, have been reported to inhibit in vitro infection by HIV-1...
- DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13E J Soilleux
Immunology, Department of Pathology, Cambridge University, United Kingdom
J Immunol 165:2937-42. 2000..The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization...
- DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in transS Pohlmann
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 806 Abramson, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 98:2670-5. 2001....
- A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infectionA A Bashirova
Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
J Exp Med 193:671-8. 2001..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
- A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligandsD A Mitchell
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Biol Chem 276:28939-45. 2001..Binding to clustered oligosaccharides may also explain the interaction of these receptors with the gp120 envelope protein of human immunodeficiency virus-1, which contributes to virus infection...
- C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in transCarmen P Alvarez
Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
J Virol 76:6841-4. 2002..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
- Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunityElizabeth J Soilleux
Medical Research Council Cancer Centre Unit, Hutchison MRC Research Centre, Cambridge, UK
Hum Pathol 33:652-9. 2002..Finally, we demonstrate that DC-SIGN and DC-SIGNR can be coexpressed on lymph node sinus endothelial cells, which may lead to modulation of the function of both molecules...
- DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2Pierre Yves Lozach
Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
J Biol Chem 278:20358-66. 2003..High affinity interaction of viral glycoproteins with oligomeric lectins might represent a strategy by which HCV targets to and concentrates in the liver and infects dendritic cells...
- Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNRYuan Guo
Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
Nat Struct Mol Biol 11:591-8. 2004..Thus, whereas DC-SIGN has dual ligand-binding properties and functions both in adhesion and in endocytosis of pathogens, DC-SIGNR binds a restricted set of ligands and has only the properties of an adhesion receptor...
- Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNRHadar Feinberg
Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 280:1327-35. 2005....
- Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptorGreg A Snyder
Laboratory of Immunogenetics, Structural Immunology Section, NIAID, NIH, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
J Virol 79:4589-98. 2005..Our work contradicts the function of DC-SIGN as a Trojan horse to facilitate HIV-1 infection; rather, it supports the function of DC-SIGN/R (a designation referring to both DC-SIGN and DC-SIGNR) as an antigen-capturing receptor...
- Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoformsHuanliang Liu
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
Eur J Hum Genet 13:707-15. 2005The repeat region of DC-SIGNR (CD209L) is polymorphic on the genomic level, and, in a separate study, we observed a correlation between the DC-SIGNR genotype and HIV-1 susceptibility during sexual contact...
- Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infectionVera S F Chan
Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
Nat Genet 38:38-46. 2006..L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem ..
- Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibilityHuanliang Liu
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
J Infect Dis 193:698-702. 2006..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...
- [Analysis of DC-SIGN and DC-SIGNR genetic polymorphism in Chinese Han population]Hui Wang
Department of AIDS Clinical Research, Shenzhen Donghu Hospital, Shenzhen, Guangdong 518020, P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:466-9. 2006..To understand the genetic polymorphism of DC-SIGN's and DC-SIGNR's neck regions in normal Chinese Han population, and to obtain the genetic data of the two loci in Chinese Han population...
- DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibilityGeneviève Boily-Larouche
Laboratoire d Immunogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Hum Immunol 68:523-30. 2007....
- The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infectionNuanjun Wichukchinda
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
AIDS Res Hum Retroviruses 23:686-92. 2007..50 (0.27,0.90)]. These associations suggest that DC-SIGNR may affect susceptibility to HIV infection by a mechanism that is different in females and males. Further studies are warranted to investigate the mechanisms of their function...
- Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individualsAnurag Rathore
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebarelli Road, Lucknow 226014, India
J Clin Immunol 28:50-7. 2008..009). A unique genotype 8/5 heterozygous was also found in HIV-1 seropositive individual, which is not reported elsewhere...
- DC-SIGN and L-SIGN: the SIGNs for infectionUi Soon Khoo
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, University Pathology Building, Hong Kong, SAR, China
J Mol Med (Berl) 86:861-74. 2008..DC-SIGN or CD209) and liver/lymph node-specific ICAM-3 grabbing non-integrin (L-SIGN also known as DC-SIGNR, CD209L or CLEC4M) directly recognize a wide range of micro-organisms of major impact on public health...
- Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian IndiansOmkar Chaudhary
Department of Biochemistry, Room No 3002, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
J Clin Virol 43:196-201. 2008..of SDF1-3'A by PCR-restriction fragment length polymorphism (RFLP) and repeat region polymorphisms in DC-SIGN and DC SIGNR by PCR in healthy HIV seronegative individuals, high risk STD patients seronegative for HIV, and HIV-1 ..
- Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1Geneviève Boily-Larouche
Laboratoire d Immunogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Canada
PLoS ONE 4:e7211. 2009..the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and ..
- Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNRHadar Feinberg
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Mol Biol 394:613-20. 2009..nonintegrin; CD209) and DC-SIGNR (DC-SIGN-related receptor, also known as L-SIGN and variously designated CD209L and CD299) are projected from the membrane surface by extended neck domains containing multiple repeats of a ..
- The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmissionLijun Xu
Clinical Center of HIV AIDS, Fuzhou Infectious Disease Hospital, Fujian Medical University, No 315, Xihong Rd, Fuzhou City 350025, China
J Clin Immunol 30:402-7. 2010..Determine if different DC-SIGNR genotypes/alleles correlated with HIV susceptibility in the context of the HIV mode of infection, CD4+ T cell counts and blood HIV RNA loads...
- Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulinZhuqing Zhang
Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian 116044, China
Biochem Cell Biol 91:214-20. 2013..These results suggest that DC-SIGNR is a biological molecule that may be potentially useful in NHL clinical settings. ..
- Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcriptsS Mummidi
South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas 78229 4404, USA
J Biol Chem 276:33196-212. 2001..e. the immunological synapse...
- Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophilsKlaas P J M van Gisbergen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
FEBS Lett 579:6159-68. 2005..This indicates that glycosylation-driven binding of both Mac-1 and CEACAM1 to DC-SIGN is essential for interactions of neutrophils with DCs and enables neutrophils to modulate T cell responses through interactions with DCs...
- The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infectionJ Nattermann
Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
J Viral Hepat 13:42-6. 2006..05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy...
- Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bankM Yokoyama-Kobayashi
Kato Cytoprotein Network Project, ERATO, JST, 4 4 1 Nishi ohnuma, Sagamihara, Kanagawa 229 0012, Japan
Gene 228:161-7. 1999..This fibrin sheet method was successfully applied to select five novel cDNA clones encoding putative type II membrane proteins from a human full-length cDNA bank...
- Autonomous tetramerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNRQuan D Yu
Division of Molecular Biosciences, Department of Life Sciences, Imperial College, London SW7 2AZ, UK
J Mol Biol 387:1075-80. 2009..binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ..
- The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoniSandra Meyer
Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
Glycobiology 17:1104-19. 2007....
- Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNRStephen A Parent
Department of Immunology and Rheumatology, Merck Research Laboratories, PO Box 2000, RY 80Y 225, Rahway, NJ 07065, USA
Gene 293:33-46. 2002..In situ hybridization and immunocytochemistry experiments demonstrate that, like human DC-SIGN, the murine messenger RNAs are expressed in subsets of dendritic cells in the spleen and skin...
- Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivoTeunis B H Geijtenbeek
Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
Blood 100:2908-16. 2002..Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues...
- Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph nodeWanli Liu
Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese Human Genome Center at Beijing, 27 Taiping Road, Beijing 100850, People s Republic of China
J Biol Chem 279:18748-58. 2004..Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor...
- Identification of a porcine DC-SIGN-related C-type lectin, porcine CLEC4G (LSECtin), and its order of intron removal during splicing: comparative genomic analyses of the cluster of genes CD23/CLEC4G/DC-SIGN among mammalian speciesY W Huang
Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
Dev Comp Immunol 33:747-60. 2009..The L-SIGN homologues do not exist in non-primates mammals. The evolutionary processes of the gene cluster, from marsupials to primates, were proposed based upon their genomic structures and phylogenetic relationships...
- High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitusRebecca Ilyas
Clinical Sciences Research Institute, University of Warwick, UK
Immunobiology 216:126-31. 2011..Mechanisms involve competitive inhibition of carbohydrate binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins...
- Evolutionary trajectories of primate genes involved in HIV pathogenesisMillan Ortiz
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
Mol Biol Evol 26:2865-75. 2009..of residues under positive selection in 13 proteins: AKT1, APOBEC3G, APOBEC3H, CD4, DEFB1, GML, IL4, IL8RA, L-SIGN/CLEC4M, PTPRC/CD45, Tetherin/BST2, TLR7, and TRIM5alpha. A number of those residues are relevant for HIV-1 biology...
- SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epitheliumAmy C Sims
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Virus Res 133:33-44. 2008..Efficient SARS-CoV infection of ciliated cell-types in HAE provides a useful in vitro model of human lung origin to study characteristics of SARS-CoV replication and pathogenesis...
- DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived virusesWilliam B Klimstra
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
J Virol 77:12022-32. 2003....
- The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNRAndrea Marzi
Institute for Clinical and Molecular Virology and Nikolaus Fiebiger Center, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
J Virol 80:6305-17. 2006..In summary, we identified the level of GP incorporation into virions and signal peptide-controlled glycosylation of GP as determinants of attachment factor engagement...
- Glycans modulate immune responses in helminth infections and allergyIrma van Die
Glycoimmunology Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Chem Immunol Allergy 90:91-112. 2006..The host protects itself against too much damage by down-regulating helminth-induced Th2 immune responses, and may thus simultaneously be protected against excessive Th2 cell-mediated allergic responses...
- DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cellsGraham Simmons
Department of Molecular Histopathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom
Virology 305:115-23. 2003....
- The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L regionLuis B Barreiro
Centre National de la Recherche Scientifique FRE 2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, 25, 75724 Paris Cedex 15, France
Am J Hum Genet 77:869-86. 2005..Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they directly recognize a plethora of pathogens, including bacteria, viruses,..
- The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)Carl W Davis
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 281:37183-94. 2006Mammalian cell-derived West Nile virus preferentially infects cells expressing the C-type lectin CD209L (dendritic cellspecific ICAM-3 grabbing nonintegrin-related protein; liver- and lymph node-specific ICAM-3 grabbing nonintegrin) but ..
- Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteinsHadar Feinberg
Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 282:4202-9. 2007....
- Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaquesBrian Jameson
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Virol 76:1866-75. 2002..Finally, we identified a MAb that blocked simian immunodeficiency virus interactions with rhesus macaque DC-SIGN. This and other specific MAbs may be used to assess the relevance of DC-SIGN in virus transmission in vivo...
- Branched oligosaccharide structures on HBV prevent interaction with both DC-SIGN and L-SIGNM L Op den Brouw
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
J Viral Hepat 15:675-83. 2008..On the basis of these findings, it is tempting to speculate that HBV exploits mannose trimming as a way to escape recognition by DC-SIGN and thereby subvert a possible immune activation response...
- The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primatesM Ortiz
Institute of Microbiology, University of Lausanne, Lausanne, Switzerland
Genes Immun 9:483-92. 2008The CD209 gene family that encodes C-type lectins in primates includes CD209 (DC-SIGN), CD209L (L-SIGN) and CD209L2...
- Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmissionLi Wu
HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
J Virol 76:5905-14. 2002..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
- L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virusJason P Gardner
Progenics Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Proc Natl Acad Sci U S A 100:4498-503. 2003..Thus, L-SIGN represents a liver-specific receptor for HCV, and L-SIGN and DC-SIGN may play important roles in HCV infection and immunity...
- West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infectionCarl W Davis
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Virol 80:1290-301. 2006..We believe this is the first report of a pathogen interacting more efficiently with DC-SIGNR than with DC-SIGN. Our results should lead to the discovery of new mechanisms by which these well-studied lectins discriminate among ligands...
- Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibilityLuis B Barreiro
CNRS FRE2849, Unit of Human Evolutionary Genetics, Institut Pasteur, Paris, France
Hum Immunol 68:106-12. 2007....
- Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanionsJoeri Auwerx
Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
Antiviral Res 83:61-70. 2009..The excess value of CBAs and polyanions to prevent HIV-1 capture and transmission by DC-SIGN and L-SIGN-expressing cells to susceptible T-lymphocytes could be of interest for the development of new drug leads targeting HIV entry/fusion...
- DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirusAndrea Marzi
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
J Virol 78:12090-5. 2004..SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo...
- Pathogenesis of severe acute respiratory syndromeYu Lung Lau
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Room 117 New Clinical Building, Queen Mary Hospital, Pokfulam Road, Hong Kong
Curr Opin Immunol 17:404-10. 2005..Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus...
- Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteinsAlex S Powlesland
Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK
J Biol Chem 281:20440-9. 2006..The results presented demonstrate that the mouse homologs of DC-SIGN have a diverse set of ligand-binding and intracellular trafficking properties, some of which are distinct from the properties of any of the human receptors...
- The Immunobiology of SARS*Jun Chen
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
Annu Rev Immunol 25:443-72. 2007..Angiotensin-converting enzyme 2 is the functional receptor for SARS-CoV; DC-SIGN and CD209L (L-SIGN) can enhance viral entry...
- The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteinsPierre Yves Lozach
Laboratoire de Pathogénie Virale Moléculaire, Institut Pasteur, Paris, France
Methods Mol Biol 379:51-68. 2007..We will also describe techniques to investigate the molecular mechanisms by which DC-SIGN or L-SIGN spread viral infections...
- A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lungYongxiong Chen
Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
J Exp Med 204:2529-36. 2007..enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L)...
- An intercellular adhesion molecule-3 (ICAM-3) -grabbing nonintegrin (DC-SIGN) efficiently blocks HIV viral buddingQiuwei Wang
UCLA School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
FASEB J 22:1055-64. 2008....
- Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cellsZania Stamataki
Hepatitis C Virus Research Group, Division of Immunity and Infection, Institute for Cancer Studies, UK
Blood 113:585-93. 2009..HCV promoted the adhesion of primary B cells to Huh-7 hepatomas, providing a mechanism for B-cell retention in the infected liver. In summary, B cells may provide a vehicle for HCV to persist and transmit to the liver...
- Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infectionFranck Halary
Laboratoire d Immunologie, CNRS UMR 5540, Universite Bordeaux 2, France
Immunity 17:653-64. 2002..These results provide new insights into the molecular interactions contributing to cell infection by CMV and extend DC-SIGN implication in virus propagation...
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cellsBoonrat Tassaneetrithep
Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
J Exp Med 197:823-9. 2003..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
- DC-SIGN: binding receptor for HCV?Zhi Hua Feng
The Center of Diagnosis and Treatment for Infectious Diseases of PLA, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
World J Gastroenterol 10:925-9. 2004....
- DC-SIGN: binding receptors for hepatitis C virusQuan Chu Wang
PLA Center for Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
Chin Med J (Engl) 117:1395-400. 2004..To review the recent developments in and research into binding receptors of hepatitis C virus (HCV) and especially the role of dendritic cell-specific adhesion receptor (DC-SIGN) in HCV...
- Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cellsJean Francois Arrighi
Department of Dermatology and Venereology, University Hospital of Geneva, 4 752, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
J Virol 78:10848-55. 2004..The present system should have broad applications for studying the function of DC-SIGN in the pathogenesis of HIV as well as other pathogens also recognized by this receptor...
- Virus attachment and entry offer numerous targets for antiviral therapyRalf Altmeyer
HKU Pasteur Research Centre, Dexter HC Man Building, 8, Sassoon Road, Hong Kong
Curr Pharm Des 10:3701-12. 2004....
- Recent advances in our understanding of receptor binding, viral fusion and cell entry of hepatitis C virus: new targets for the design of antiviral agentsPantelis Poumbourios
Viral Fusion Laboratory, Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Australia
Antivir Chem Chemother 18:169-89. 2007..In addition, key questions on the role that these receptors play in viral entry are raised and potential avenues for the discovery of new antiviral agents are highlighted...
- Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGNMuhammad Mukhtar
The Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Virology 297:78-88. 2002..These data will assist in further understanding lentiviral entry into the CNS...
- DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?Elizabeth J Soilleux
Medical Research Council Cancer Cell Unit, Hutchison M R C Research Centre, Hills Road, Cambridge CB2 2XY, U K
Clin Sci (Lond) 104:437-46. 2003..Finally, the role of DC-SIGN in pathology, particularly in infective and neoplastic processes, is discussed, followed by speculation about likely future developments in this field...
- HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver diseaseG Cole
J Clin Pathol 57:79-80. 2004..This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism...
- C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particlesPierre Yves Lozach
Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
J Biol Chem 279:32035-45. 2004..Our results support the hypothesis that C-type lectins such as the liver sinusoidal endothelial cell-expressed L-SIGN could act as a capture receptor for HCV in the liver and transmit infectious virions to neighboring hepatocytes...
- Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytesEsther Caparros
Centro de Investigaciones Biologicas CSIC, Calle Ramiro de Maeztu 9, 28040 Madrid, Spain
Immunobiology 210:185-93. 2005..A deeper knowledge of the parasite-C-type lectin interaction may be helpful for the design of new DC-based therapeutic vaccines against Leishmania infections...
- Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogensThomas Gramberg
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, 91054 Erlangen, Germany
Virology 347:354-63. 2006....
- The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cellsAngeles Dominguez-Soto
Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
Blood 109:5337-45. 2007..In addition, our results suggest that LSECtin participates in antigen uptake and internalization, and might be a suitable target molecule in vaccination strategies...
- Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infectionNelson Leung Sang Tang
Nat Genet 39:691-2; author reply 694-6. 2007
- Analysis of the interaction of Ebola virus glycoprotein with DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) and its homologue DC-SIGNRAndrea Marzi
Institute of Virology, Nikolaus Fiebiger Center for Molecular Medicine, Erlangen, Germany
J Infect Dis 196:S237-46. 2007..However, it its unclear whether DC-SIGN promotes only EBOV attachment (attachment factor function, nonessential) or actively facilitates EBOV entry (receptor function, essential)...
- HIV-1 infected Germans have more variations on neck region of DC-specific intercellular adhesion molecule-3-grabbing nonintegrin than HIV-1 infected ChineseX Li-Jun
Institute of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang Province, China
Eur J Med Res 13:59-62. 2008..Comparison of those variations between Chinese and Germans reveals strong ethnic discrepancies, and no significant evidence indicates those variations have resistance to susceptibility to HIV-1 infection...
- The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1Angeles Dominguez-Soto
Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
Hepatology 49:287-96. 2009..Moreover, knockdown of PU.1 through the use of small interfering RNA led to a decrease in LSECtin mRNA levels in THP-1 and monocyte-derived dendritic cells, thus confirming the involvement of PU.1 in the myeloid expression of the lectin...
- Gene-gene interaction between tuberculosis candidate genes in a South African populationErika de Wit
Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
Mamm Genome 22:100-10. 2011..Methods for studying gene-gene interactions are based on a multilocus and multigene approach, consistent with the nature of complex-trait diseases, and may provide the paradigm for future genetic studies of TB...
- Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificitiesReiko T Lee
Department of Biology, T he Johns Hopkins University, Baltimore, MD, USA
Glycobiology 21:512-20. 2011..BDCA-2, dectin-2, Langerin, MCL and mannose receptor did not bind Le(x) at all...
- S-layer proteins of Lactobacillus acidophilus inhibits JUNV infectionMaría Guadalupe Martínez
Departamento de Quimica Biologica, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria Pabellón II 4 piso, C1428EGA Buenos Aires, Argentina
Biochem Biophys Res Commun 422:590-5. 2012..type cells or in 3T3 cells expressing liver/lymph node-specific ICAM-3 grabbing nonintegrin (L-SIGN or DC-SIGNR or CD209L)...
- The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysisHui Li
Department of Genetics and Developmental Biology, Southeast University School of Medicine, Nanjing, China
PLoS ONE 7:e42972. 2012..Studies of the association between the variable number tandem repeat (VNTR) polymorphism of the DC-SIGNR gene and HIV-1 susceptibility have produced controversial results...
- Comprehensive and comparative transcription analyses of the complement pathway in rainbow troutJudith M Köbis
Leibniz Institut für Nutztierbiologie FBN, Institut für Genombiologie, Dummerstorf, Germany
Fish Shellfish Immunol 42:98-107. 2015..the genes encoding complement factor D (CFD), CD93 molecule (CD93), and C-type lectin domain family 4, member M (CLEC4M) from rainbow trout (Oncorhynchus mykiss)...
- Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGNLeah Gillespie
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
Sci Rep 6:19428. 2016..The C-type lectin receptors (CLRs) DC-SIGN (CD209) and L-SIGN (CD209L) enhance IAV infection however it is not known if they act as attachment factors, passing virions to other unknown ..
- Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 TransmissionLina Pednekar
Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK
Front Immunol 7:600. 2016..Our results highlight the consequences of multiple innate immune pattern recognition molecules forming a complex that can modify their functions in a way, which may be advantageous for the pathogen...
- Isolation and characterization of the human DC-SIGN and DC-SIGNR promotersHongbing Liu
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Gene 313:149-59. 2003..Thus, despite its highly restricted pattern of expression, the DC-SIGN promoter has features common to promoters that are active in other cell types...
- Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1Estella A Koppel
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Immunobiology 209:117-27. 2004..Moreover, the identification of SIGNR1 as a receptor for ManLAM will enable in vivo studies to investigate the role of DC-SIGN in M. tuberculosis pathogenesis...
- LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirusThomas Gramberg
Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
Virology 340:224-36. 2005..In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes...
- Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasisJ H Martens
Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
J Pathol 208:574-89. 2006....
- DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotypeLuis B Barreiro
J Infect Dis 194:1184-5; author reply 1185-7. 2006
- Hepatitis C virus entry: role of host and viral factorsBaila Samreen
National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
Infect Genet Evol 12:1699-709. 2012..In the current review we try to summarize the current knowledge about mechanism and interaction of cellular and viral factors involved in HCV cell entry and its implication as therapeutic target to inhibit HCV infection...
- Impact of viral attachment factor expression on antibody-mediated neutralization of flavivirusesChristopher J Obara
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA
Virology 437:20-7. 2013..Altogether, our studies suggest that cellular attachment factor expression is not a significant contributor to the potency of neutralizing antibodies to flaviviruses...
- The origin and evolution of variable number tandem repeat of CLEC4M gene in the global human populationHui Li
Department of Genetics and Developmental Biology, Southeast University School of Medicine and The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, China
PLoS ONE 7:e30268. 2012b>CLEC4M is a C-type lectin gene serving as cell adhesion receptor and pathogen recognition receptor. It recognizes several pathogens of important public health concern...
- Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGNC G Park
Laboratory of Cellular Physiology and Immunology, Box 176, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Int Immunol 13:1283-90. 2001..This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC...
- Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGNF Baribaud
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 75:10281-9. 2001....
- CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINSWILLIAM WEIS; Fiscal Year: 2006..In order to understand the specificity of DC-SIGN and DCSIGNR towards high-mannose oligosaccharides and glycoproteins, structures of complexes between these proteins and high-..
- Modulation of DC-SIGN and DC-SIGNR by KSHVRobert E Means; Fiscal Year: 2012..abstract_text> ..
- Effect of DC-SIGNR Polymorphisms on HIV-1 InfectionTuofu Zhu; Fiscal Year: 2003..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
- Identifying determinants of Hepatitis C Virus (HCV) tropismTatjana Dragic; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Role of DC-SIGN in HIV infectionSunil Ahuja; Fiscal Year: 2003..Our studies also place us in a unique position to pursue strategies to block DC-HIV interactions thought to be necessary for HIV transmission. ..
- Interactions Between HIV and SIV with DC-SIGN & DC-SIGNRROBERT DOMS; Fiscal Year: 2005....
- DC-SIGN and DC-SIGNR Genetic Variations and HIV Transmission in IndiaHuanliang Liu; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..