CLEC4M

Summary

Gene Symbol: CLEC4M
Description: C-type lectin domain family 4 member M
Alias: CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, CD299 antigen, DC-SIGN-related protein, dendritic cell-specific ICAM-3-grabbing non-integrin 2, liver/lymph node-specific ICAM-3 grabbing non-integrin, mannose binding C-type lectin DC-SIGNR
Species: human

Top Publications

  1. doi Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission
    Ronaldo Celerino da Silva
    Department of Genetics, Federal University of Pernambuco, Cidade Universitaria, Recife, PE, Brazil
    Hum Immunol 72:305-11. 2011
  2. pmc Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection
    Varsha Srivastava
    Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 284:25532-41. 2009
  3. pmc HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
  4. pmc Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120
    B M Curtis
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121
    Proc Natl Acad Sci U S A 89:8356-60. 1992
  5. ncbi Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)
    L Gattegno
    Laboratoire de Biologie Cellulaire, Faculté de Médecine Paris Nord, Bobigny, France
    AIDS Res Hum Retroviruses 8:27-37. 1992
  6. ncbi DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13
    E J Soilleux
    Immunology, Department of Pathology, Cambridge University, United Kingdom
    J Immunol 165:2937-42. 2000
  7. pmc DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
    S Pohlmann
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 806 Abramson, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:2670-5. 2001
  8. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
  9. ncbi A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands
    D A Mitchell
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 276:28939-45. 2001
  10. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. doi Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission
    Ronaldo Celerino da Silva
    Department of Genetics, Federal University of Pernambuco, Cidade Universitaria, Recife, PE, Brazil
    Hum Immunol 72:305-11. 2011
    ..This review aims to explore the involvement of the DC-SIGN and L-SIGN receptors in HIV-1 transmission from mother to child...
  2. pmc Toll-like receptor 2 and DC-SIGNR1 differentially regulate suppressors of cytokine signaling 1 in dendritic cells during Mycobacterium tuberculosis infection
    Varsha Srivastava
    Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 284:25532-41. 2009
    ..tb. These results indicate that TLR2 and DC-SIGNR1 differentially regulate SOCS1 expression during M. tb infection. This in turn regulates M. tb survival by governing key cytokine expression...
  3. pmc HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN)
    Nancy P Y Chung
    HIV Drug Resistance Program, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2100-12. 2010
    ..These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity...
  4. pmc Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120
    B M Curtis
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121
    Proc Natl Acad Sci U S A 89:8356-60. 1992
    ..Collectively, these data demonstrate that the gp120-binding protein is a membrane-associated mannose-binding lectin. Proteins of this type may play an important role in the CD4-independent association of HIV with cells...
  5. ncbi Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1)
    L Gattegno
    Laboratoire de Biologie Cellulaire, Faculté de Médecine Paris Nord, Bobigny, France
    AIDS Res Hum Retroviruses 8:27-37. 1992
    ..These findings obtained with plant lectins may be of relevance in vivo, inasmuch as endogenous mannosyl-binding proteins, which are known to function as opsonins, have been reported to inhibit in vitro infection by HIV-1...
  6. ncbi DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13
    E J Soilleux
    Immunology, Department of Pathology, Cambridge University, United Kingdom
    J Immunol 165:2937-42. 2000
    ..The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization...
  7. pmc DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
    S Pohlmann
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 806 Abramson, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:2670-5. 2001
    ....
  8. pmc A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection
    A A Bashirova
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Frederick, MD 21702, USA
    J Exp Med 193:671-8. 2001
    ..We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1...
  9. ncbi A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands
    D A Mitchell
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 276:28939-45. 2001
    ..Binding to clustered oligosaccharides may also explain the interaction of these receptors with the gp120 envelope protein of human immunodeficiency virus-1, which contributes to virus infection...
  10. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  11. ncbi Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity
    Elizabeth J Soilleux
    Medical Research Council Cancer Centre Unit, Hutchison MRC Research Centre, Cambridge, UK
    Hum Pathol 33:652-9. 2002
    ..Finally, we demonstrate that DC-SIGN and DC-SIGNR can be coexpressed on lymph node sinus endothelial cells, which may lead to modulation of the function of both molecules...
  12. ncbi DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
    J Biol Chem 278:20358-66. 2003
    ..High affinity interaction of viral glycoproteins with oligomeric lectins might represent a strategy by which HCV targets to and concentrates in the liver and infects dendritic cells...
  13. ncbi Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR
    Yuan Guo
    Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 11:591-8. 2004
    ..Thus, whereas DC-SIGN has dual ligand-binding properties and functions both in adhesion and in endocytosis of pathogens, DC-SIGNR binds a restricted set of ligands and has only the properties of an adhesion receptor...
  14. ncbi Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR
    Hadar Feinberg
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:1327-35. 2005
    ....
  15. pmc Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor
    Greg A Snyder
    Laboratory of Immunogenetics, Structural Immunology Section, NIAID, NIH, Twinbrook II, 12441 Parklawn Dr, Rockville, MD 20852, USA
    J Virol 79:4589-98. 2005
    ..Our work contradicts the function of DC-SIGN as a Trojan horse to facilitate HIV-1 infection; rather, it supports the function of DC-SIGN/R (a designation referring to both DC-SIGN and DC-SIGNR) as an antigen-capturing receptor...
  16. ncbi Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Eur J Hum Genet 13:707-15. 2005
    The repeat region of DC-SIGNR (CD209L) is polymorphic on the genomic level, and, in a separate study, we observed a correlation between the DC-SIGNR genotype and HIV-1 susceptibility during sexual contact...
  17. ncbi Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
    Vera S F Chan
    Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China
    Nat Genet 38:38-46. 2006
    ..L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem ..
  18. ncbi Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...
  19. ncbi [Analysis of DC-SIGN and DC-SIGNR genetic polymorphism in Chinese Han population]
    Hui Wang
    Department of AIDS Clinical Research, Shenzhen Donghu Hospital, Shenzhen, Guangdong 518020, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:466-9. 2006
    ..To understand the genetic polymorphism of DC-SIGN's and DC-SIGNR's neck regions in normal Chinese Han population, and to obtain the genetic data of the two loci in Chinese Han population...
  20. ncbi DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility
    Geneviève Boily-Larouche
    Laboratoire d Immunogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hum Immunol 68:523-30. 2007
    ....
  21. ncbi The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection
    Nuanjun Wichukchinda
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    AIDS Res Hum Retroviruses 23:686-92. 2007
    ..50 (0.27,0.90)]. These associations suggest that DC-SIGNR may affect susceptibility to HIV infection by a mechanism that is different in females and males. Further studies are warranted to investigate the mechanisms of their function...
  22. ncbi Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals
    Anurag Rathore
    Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebarelli Road, Lucknow 226014, India
    J Clin Immunol 28:50-7. 2008
    ..009). A unique genotype 8/5 heterozygous was also found in HIV-1 seropositive individual, which is not reported elsewhere...
  23. doi DC-SIGN and L-SIGN: the SIGNs for infection
    Ui Soon Khoo
    Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, University Pathology Building, Hong Kong, SAR, China
    J Mol Med (Berl) 86:861-74. 2008
    ..DC-SIGN or CD209) and liver/lymph node-specific ICAM-3 grabbing non-integrin (L-SIGN also known as DC-SIGNR, CD209L or CLEC4M) directly recognize a wide range of micro-organisms of major impact on public health...
  24. doi Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians
    Omkar Chaudhary
    Department of Biochemistry, Room No 3002, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Clin Virol 43:196-201. 2008
    ..of SDF1-3'A by PCR-restriction fragment length polymorphism (RFLP) and repeat region polymorphisms in DC-SIGN and DC SIGNR by PCR in healthy HIV seronegative individuals, high risk STD patients seronegative for HIV, and HIV-1 ..
  25. pmc Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1
    Geneviève Boily-Larouche
    Laboratoire d Immunogénétique, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    PLoS ONE 4:e7211. 2009
    ..the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and ..
  26. pmc Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR
    Hadar Feinberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Mol Biol 394:613-20. 2009
    ..nonintegrin; CD209) and DC-SIGNR (DC-SIGN-related receptor, also known as L-SIGN and variously designated CD209L and CD299) are projected from the membrane surface by extended neck domains containing multiple repeats of a ..
  27. doi The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmission
    Lijun Xu
    Clinical Center of HIV AIDS, Fuzhou Infectious Disease Hospital, Fujian Medical University, No 315, Xihong Rd, Fuzhou City 350025, China
    J Clin Immunol 30:402-7. 2010
    ..Determine if different DC-SIGNR genotypes/alleles correlated with HIV susceptibility in the context of the HIV mode of infection, CD4+ T cell counts and blood HIV RNA loads...
  28. doi Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulin
    Zhuqing Zhang
    Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian 116044, China
    Biochem Cell Biol 91:214-20. 2013
    ..These results suggest that DC-SIGNR is a biological molecule that may be potentially useful in NHL clinical settings. ..
  29. ncbi Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts
    S Mummidi
    South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas 78229 4404, USA
    J Biol Chem 276:33196-212. 2001
    ..e. the immunological synapse...
  30. ncbi Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    FEBS Lett 579:6159-68. 2005
    ..This indicates that glycosylation-driven binding of both Mac-1 and CEACAM1 to DC-SIGN is essential for interactions of neutrophils with DCs and enables neutrophils to modulate T cell responses through interactions with DCs...
  31. ncbi The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection
    J Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    J Viral Hepat 13:42-6. 2006
    ..05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy...
  32. ncbi Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank
    M Yokoyama-Kobayashi
    Kato Cytoprotein Network Project, ERATO, JST, 4 4 1 Nishi ohnuma, Sagamihara, Kanagawa 229 0012, Japan
    Gene 228:161-7. 1999
    ..This fibrin sheet method was successfully applied to select five novel cDNA clones encoding putative type II membrane proteins from a human full-length cDNA bank...
  33. pmc Autonomous tetramerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR
    Quan D Yu
    Division of Molecular Biosciences, Department of Life Sciences, Imperial College, London SW7 2AZ, UK
    J Mol Biol 387:1075-80. 2009
    ..binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ..
  34. ncbi The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoni
    Sandra Meyer
    Institute of Biochemistry, Medical Faculty, Justus Liebig University Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    Glycobiology 17:1104-19. 2007
    ....
  35. ncbi Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR
    Stephen A Parent
    Department of Immunology and Rheumatology, Merck Research Laboratories, PO Box 2000, RY 80Y 225, Rahway, NJ 07065, USA
    Gene 293:33-46. 2002
    ..In situ hybridization and immunocytochemistry experiments demonstrate that, like human DC-SIGN, the murine messenger RNAs are expressed in subsets of dendritic cells in the spleen and skin...
  36. ncbi Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    Blood 100:2908-16. 2002
    ..Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues...
  37. ncbi Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node
    Wanli Liu
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese Human Genome Center at Beijing, 27 Taiping Road, Beijing 100850, People s Republic of China
    J Biol Chem 279:18748-58. 2004
    ..Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor...
  38. doi Identification of a porcine DC-SIGN-related C-type lectin, porcine CLEC4G (LSECtin), and its order of intron removal during splicing: comparative genomic analyses of the cluster of genes CD23/CLEC4G/DC-SIGN among mammalian species
    Y W Huang
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1410 Price s Fork Road, Blacksburg, VA 24061 0342, USA
    Dev Comp Immunol 33:747-60. 2009
    ..The L-SIGN homologues do not exist in non-primates mammals. The evolutionary processes of the gene cluster, from marsupials to primates, were proposed based upon their genomic structures and phylogenetic relationships...
  39. pmc High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus
    Rebecca Ilyas
    Clinical Sciences Research Institute, University of Warwick, UK
    Immunobiology 216:126-31. 2011
    ..Mechanisms involve competitive inhibition of carbohydrate binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins...
  40. doi Evolutionary trajectories of primate genes involved in HIV pathogenesis
    Millan Ortiz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Mol Biol Evol 26:2865-75. 2009
    ..of residues under positive selection in 13 proteins: AKT1, APOBEC3G, APOBEC3H, CD4, DEFB1, GML, IL4, IL8RA, L-SIGN/CLEC4M, PTPRC/CD45, Tetherin/BST2, TLR7, and TRIM5alpha. A number of those residues are relevant for HIV-1 biology...
  41. pmc SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
    Amy C Sims
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Virus Res 133:33-44. 2008
    ..Efficient SARS-CoV infection of ciliated cell-types in HAE provides a useful in vitro model of human lung origin to study characteristics of SARS-CoV replication and pathogenesis...
  42. pmc DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses
    William B Klimstra
    Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    J Virol 77:12022-32. 2003
    ....
  43. pmc The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR
    Andrea Marzi
    Institute for Clinical and Molecular Virology and Nikolaus Fiebiger Center, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    J Virol 80:6305-17. 2006
    ..In summary, we identified the level of GP incorporation into virions and signal peptide-controlled glycosylation of GP as determinants of attachment factor engagement...
  44. ncbi Glycans modulate immune responses in helminth infections and allergy
    Irma van Die
    Glycoimmunology Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Chem Immunol Allergy 90:91-112. 2006
    ..The host protects itself against too much damage by down-regulating helminth-induced Th2 immune responses, and may thus simultaneously be protected against excessive Th2 cell-mediated allergic responses...
  45. ncbi DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells
    Graham Simmons
    Department of Molecular Histopathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom
    Virology 305:115-23. 2003
    ....
  46. pmc The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region
    Luis B Barreiro
    Centre National de la Recherche Scientifique FRE 2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, 25, 75724 Paris Cedex 15, France
    Am J Hum Genet 77:869-86. 2005
    ..Two closely related innate immunity genes, CD209 and CD209L, are particularly interesting because they directly recognize a plethora of pathogens, including bacteria, viruses,..
  47. ncbi The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin)
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:37183-94. 2006
    Mammalian cell-derived West Nile virus preferentially infects cells expressing the C-type lectin CD209L (dendritic cellspecific ICAM-3 grabbing nonintegrin-related protein; liver- and lymph node-specific ICAM-3 grabbing nonintegrin) but ..
  48. pmc Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins
    Hadar Feinberg
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:4202-9. 2007
    ....
  49. pmc Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques
    Brian Jameson
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 76:1866-75. 2002
    ..Finally, we identified a MAb that blocked simian immunodeficiency virus interactions with rhesus macaque DC-SIGN. This and other specific MAbs may be used to assess the relevance of DC-SIGN in virus transmission in vivo...
  50. doi Branched oligosaccharide structures on HBV prevent interaction with both DC-SIGN and L-SIGN
    M L Op den Brouw
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    J Viral Hepat 15:675-83. 2008
    ..On the basis of these findings, it is tempting to speculate that HBV exploits mannose trimming as a way to escape recognition by DC-SIGN and thereby subvert a possible immune activation response...
  51. pmc The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates
    M Ortiz
    Institute of Microbiology, University of Lausanne, Lausanne, Switzerland
    Genes Immun 9:483-92. 2008
    The CD209 gene family that encodes C-type lectins in primates includes CD209 (DC-SIGN), CD209L (L-SIGN) and CD209L2...
  52. pmc Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission
    Li Wu
    HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:5905-14. 2002
    ..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission...
  53. pmc L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus
    Jason P Gardner
    Progenics Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 100:4498-503. 2003
    ..Thus, L-SIGN represents a liver-specific receptor for HCV, and L-SIGN and DC-SIGN may play important roles in HCV infection and immunity...
  54. pmc West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection
    Carl W Davis
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Virol 80:1290-301. 2006
    ..We believe this is the first report of a pathogen interacting more efficiently with DC-SIGNR than with DC-SIGN. Our results should lead to the discovery of new mechanisms by which these well-studied lectins discriminate among ligands...
  55. ncbi Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility
    Luis B Barreiro
    CNRS FRE2849, Unit of Human Evolutionary Genetics, Institut Pasteur, Paris, France
    Hum Immunol 68:106-12. 2007
    ....
  56. ncbi Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions
    Joeri Auwerx
    Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Antiviral Res 83:61-70. 2009
    ..The excess value of CBAs and polyanions to prevent HIV-1 capture and transmission by DC-SIGN and L-SIGN-expressing cells to susceptible T-lymphocytes could be of interest for the development of new drug leads targeting HIV entry/fusion...
  57. pmc DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus
    Andrea Marzi
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Nikolaus Fiebiger Center, Glückstrasse 6, D 91054 Erlangen, Germany
    J Virol 78:12090-5. 2004
    ..SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo...
  58. ncbi Pathogenesis of severe acute respiratory syndrome
    Yu Lung Lau
    Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Room 117 New Clinical Building, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Curr Opin Immunol 17:404-10. 2005
    ..Angiotensin-converting enzyme 2 (ACE2), the C-type lectin CD209L (also known L-SIGN), and DC-SIGN bind SARS-CoV, but ACE2 appears to be the key functional receptor for the virus...
  59. ncbi Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins
    Alex S Powlesland
    Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK
    J Biol Chem 281:20440-9. 2006
    ..The results presented demonstrate that the mouse homologs of DC-SIGN have a diverse set of ligand-binding and intracellular trafficking properties, some of which are distinct from the properties of any of the human receptors...
  60. ncbi The Immunobiology of SARS*
    Jun Chen
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 25:443-72. 2007
    ..Angiotensin-converting enzyme 2 is the functional receptor for SARS-CoV; DC-SIGN and CD209L (L-SIGN) can enhance viral entry...
  61. ncbi The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins
    Pierre Yves Lozach
    Laboratoire de Pathogénie Virale Moléculaire, Institut Pasteur, Paris, France
    Methods Mol Biol 379:51-68. 2007
    ..We will also describe techniques to investigate the molecular mechanisms by which DC-SIGN or L-SIGN spread viral infections...
  62. pmc A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung
    Yongxiong Chen
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    J Exp Med 204:2529-36. 2007
    ..enzyme 2, and also a binding receptor, liver/lymph node-specific ICAM-3-grabbing non-integrin (CD209L)...
  63. ncbi An intercellular adhesion molecule-3 (ICAM-3) -grabbing nonintegrin (DC-SIGN) efficiently blocks HIV viral budding
    Qiuwei Wang
    UCLA School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    FASEB J 22:1055-64. 2008
    ....
  64. pmc Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells
    Zania Stamataki
    Hepatitis C Virus Research Group, Division of Immunity and Infection, Institute for Cancer Studies, UK
    Blood 113:585-93. 2009
    ..HCV promoted the adhesion of primary B cells to Huh-7 hepatomas, providing a mechanism for B-cell retention in the infected liver. In summary, B cells may provide a vehicle for HCV to persist and transmit to the liver...
  65. ncbi Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection
    Franck Halary
    Laboratoire d Immunologie, CNRS UMR 5540, Universite Bordeaux 2, France
    Immunity 17:653-64. 2002
    ..These results provide new insights into the molecular interactions contributing to cell infection by CMV and extend DC-SIGN implication in virus propagation...
  66. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    ..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
  67. pmc DC-SIGN: binding receptor for HCV?
    Zhi Hua Feng
    The Center of Diagnosis and Treatment for Infectious Diseases of PLA, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    World J Gastroenterol 10:925-9. 2004
    ....
  68. ncbi DC-SIGN: binding receptors for hepatitis C virus
    Quan Chu Wang
    PLA Center for Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Chin Med J (Engl) 117:1395-400. 2004
    ..To review the recent developments in and research into binding receptors of hepatitis C virus (HCV) and especially the role of dendritic cell-specific adhesion receptor (DC-SIGN) in HCV...
  69. pmc Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells
    Jean Francois Arrighi
    Department of Dermatology and Venereology, University Hospital of Geneva, 4 752, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
    J Virol 78:10848-55. 2004
    ..The present system should have broad applications for studying the function of DC-SIGN in the pathogenesis of HIV as well as other pathogens also recognized by this receptor...
  70. ncbi Virus attachment and entry offer numerous targets for antiviral therapy
    Ralf Altmeyer
    HKU Pasteur Research Centre, Dexter HC Man Building, 8, Sassoon Road, Hong Kong
    Curr Pharm Des 10:3701-12. 2004
    ....
  71. ncbi Recent advances in our understanding of receptor binding, viral fusion and cell entry of hepatitis C virus: new targets for the design of antiviral agents
    Pantelis Poumbourios
    Viral Fusion Laboratory, Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Australia
    Antivir Chem Chemother 18:169-89. 2007
    ..In addition, key questions on the role that these receptors play in viral entry are raised and potential avenues for the discovery of new antiviral agents are highlighted...
  72. ncbi Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN
    Muhammad Mukhtar
    The Dorrance H Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Virology 297:78-88. 2002
    ..These data will assist in further understanding lentiviral entry into the CNS...
  73. ncbi DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?
    Elizabeth J Soilleux
    Medical Research Council Cancer Cell Unit, Hutchison M R C Research Centre, Hills Road, Cambridge CB2 2XY, U K
    Clin Sci (Lond) 104:437-46. 2003
    ..Finally, the role of DC-SIGN in pathology, particularly in infective and neoplastic processes, is discussed, followed by speculation about likely future developments in this field...
  74. pmc HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease
    G Cole
    J Clin Pathol 57:79-80. 2004
    ..This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism...
  75. ncbi C-type lectins L-SIGN and DC-SIGN capture and transmit infectious hepatitis C virus pseudotype particles
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
    J Biol Chem 279:32035-45. 2004
    ..Our results support the hypothesis that C-type lectins such as the liver sinusoidal endothelial cell-expressed L-SIGN could act as a capture receptor for HCV in the liver and transmit infectious virions to neighboring hepatocytes...
  76. ncbi Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytes
    Esther Caparros
    Centro de Investigaciones Biologicas CSIC, Calle Ramiro de Maeztu 9, 28040 Madrid, Spain
    Immunobiology 210:185-93. 2005
    ..A deeper knowledge of the parasite-C-type lectin interaction may be helpful for the design of new DC-based therapeutic vaccines against Leishmania infections...
  77. ncbi Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens
    Thomas Gramberg
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, 91054 Erlangen, Germany
    Virology 347:354-63. 2006
    ....
  78. ncbi The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells
    Angeles Dominguez-Soto
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Blood 109:5337-45. 2007
    ..In addition, our results suggest that LSECtin participates in antigen uptake and internalization, and might be a suitable target molecule in vaccination strategies...
  79. ncbi Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
    Nelson Leung Sang Tang
    Nat Genet 39:691-2; author reply 694-6. 2007
  80. ncbi Analysis of the interaction of Ebola virus glycoprotein with DC-SIGN (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) and its homologue DC-SIGNR
    Andrea Marzi
    Institute of Virology, Nikolaus Fiebiger Center for Molecular Medicine, Erlangen, Germany
    J Infect Dis 196:S237-46. 2007
    ..However, it its unclear whether DC-SIGN promotes only EBOV attachment (attachment factor function, nonessential) or actively facilitates EBOV entry (receptor function, essential)...
  81. ncbi HIV-1 infected Germans have more variations on neck region of DC-specific intercellular adhesion molecule-3-grabbing nonintegrin than HIV-1 infected Chinese
    X Li-Jun
    Institute of Infectious Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang Province, China
    Eur J Med Res 13:59-62. 2008
    ..Comparison of those variations between Chinese and Germans reveals strong ethnic discrepancies, and no significant evidence indicates those variations have resistance to susceptibility to HIV-1 infection...
  82. doi The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1
    Angeles Dominguez-Soto
    Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    Hepatology 49:287-96. 2009
    ..Moreover, knockdown of PU.1 through the use of small interfering RNA led to a decrease in LSECtin mRNA levels in THP-1 and monocyte-derived dendritic cells, thus confirming the involvement of PU.1 in the myeloid expression of the lectin...
  83. doi Gene-gene interaction between tuberculosis candidate genes in a South African population
    Erika de Wit
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    Mamm Genome 22:100-10. 2011
    ..Methods for studying gene-gene interactions are based on a multilocus and multigene approach, consistent with the nature of complex-trait diseases, and may provide the paradigm for future genetic studies of TB...
  84. pmc Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities
    Reiko T Lee
    Department of Biology, T he Johns Hopkins University, Baltimore, MD, USA
    Glycobiology 21:512-20. 2011
    ..BDCA-2, dectin-2, Langerin, MCL and mannose receptor did not bind Le(x) at all...
  85. doi S-layer proteins of Lactobacillus acidophilus inhibits JUNV infection
    María Guadalupe Martínez
    Departamento de Quimica Biologica, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria Pabellón II 4 piso, C1428EGA Buenos Aires, Argentina
    Biochem Biophys Res Commun 422:590-5. 2012
    ..type cells or in 3T3 cells expressing liver/lymph node-specific ICAM-3 grabbing nonintegrin (L-SIGN or DC-SIGNR or CD209L)...
  86. pmc The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis
    Hui Li
    Department of Genetics and Developmental Biology, Southeast University School of Medicine, Nanjing, China
    PLoS ONE 7:e42972. 2012
    ..Studies of the association between the variable number tandem repeat (VNTR) polymorphism of the DC-SIGNR gene and HIV-1 susceptibility have produced controversial results...
  87. doi Comprehensive and comparative transcription analyses of the complement pathway in rainbow trout
    Judith M Köbis
    Leibniz Institut für Nutztierbiologie FBN, Institut für Genombiologie, Dummerstorf, Germany
    Fish Shellfish Immunol 42:98-107. 2015
    ..the genes encoding complement factor D (CFD), CD93 molecule (CD93), and C-type lectin domain family 4, member M (CLEC4M) from rainbow trout (Oncorhynchus mykiss)...
  88. pmc Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN
    Leah Gillespie
    Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia
    Sci Rep 6:19428. 2016
    ..The C-type lectin receptors (CLRs) DC-SIGN (CD209) and L-SIGN (CD209L) enhance IAV infection however it is not known if they act as attachment factors, passing virions to other unknown ..
  89. pmc Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission
    Lina Pednekar
    Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK
    Front Immunol 7:600. 2016
    ..Our results highlight the consequences of multiple innate immune pattern recognition molecules forming a complex that can modify their functions in a way, which may be advantageous for the pathogen...
  90. ncbi Isolation and characterization of the human DC-SIGN and DC-SIGNR promoters
    Hongbing Liu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene 313:149-59. 2003
    ..Thus, despite its highly restricted pattern of expression, the DC-SIGN promoter has features common to promoters that are active in other cell types...
  91. ncbi Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 209:117-27. 2004
    ..Moreover, the identification of SIGNR1 as a receptor for ManLAM will enable in vivo studies to investigate the role of DC-SIGN in M. tuberculosis pathogenesis...
  92. ncbi LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus
    Thomas Gramberg
    Institute for Clinical and Molecular Virology, University Erlangen Nurnberg, Germany
    Virology 340:224-36. 2005
    ..In summary, we identified LSECtin as an attachment factor that in conjunction with DC-SIGNR might concentrate viral pathogens in liver and lymph nodes...
  93. ncbi Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
    J H Martens
    Department of Dermatology, University Medical Centre Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    J Pathol 208:574-89. 2006
    ....
  94. ncbi DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype
    Luis B Barreiro
    J Infect Dis 194:1184-5; author reply 1185-7. 2006
  95. doi Hepatitis C virus entry: role of host and viral factors
    Baila Samreen
    National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Infect Genet Evol 12:1699-709. 2012
    ..In the current review we try to summarize the current knowledge about mechanism and interaction of cellular and viral factors involved in HCV cell entry and its implication as therapeutic target to inhibit HCV infection...
  96. pmc Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses
    Christopher J Obara
    Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20852, USA
    Virology 437:20-7. 2013
    ..Altogether, our studies suggest that cellular attachment factor expression is not a significant contributor to the potency of neutralizing antibodies to flaviviruses...
  97. pmc The origin and evolution of variable number tandem repeat of CLEC4M gene in the global human population
    Hui Li
    Department of Genetics and Developmental Biology, Southeast University School of Medicine and The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, China
    PLoS ONE 7:e30268. 2012
    b>CLEC4M is a C-type lectin gene serving as cell adhesion receptor and pathogen recognition receptor. It recognizes several pathogens of important public health concern...
  98. ncbi Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN
    C G Park
    Laboratory of Cellular Physiology and Immunology, Box 176, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Int Immunol 13:1283-90. 2001
    ..This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC...
  99. pmc Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN
    F Baribaud
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 75:10281-9. 2001
    ....

Research Grants7

  1. CELL SURFACE CARBOHYDRATE RECOGNITION BY C-TYPE LECTINS
    WILLIAM WEIS; Fiscal Year: 2006
    ..In order to understand the specificity of DC-SIGN and DCSIGNR towards high-mannose oligosaccharides and glycoproteins, structures of complexes between these proteins and high-..
  2. Modulation of DC-SIGN and DC-SIGNR by KSHV
    Robert E Means; Fiscal Year: 2012
    ..abstract_text> ..
  3. Effect of DC-SIGNR Polymorphisms on HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2003
    ..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
  4. Identifying determinants of Hepatitis C Virus (HCV) tropism
    Tatjana Dragic; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. Role of DC-SIGN in HIV infection
    Sunil Ahuja; Fiscal Year: 2003
    ..Our studies also place us in a unique position to pursue strategies to block DC-HIV interactions thought to be necessary for HIV transmission. ..
  6. Interactions Between HIV and SIV with DC-SIGN & DC-SIGNR
    ROBERT DOMS; Fiscal Year: 2005
    ....
  7. DC-SIGN and DC-SIGNR Genetic Variations and HIV Transmission in India
    Huanliang Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..