Gene Symbol: CLEC4A
Description: C-type lectin domain family 4 member A
Alias: CD367, CLECSF6, DCIR, DDB27, HDCGC13P, LLIR, C-type lectin domain family 4 member A, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6, C-type lectin DDB27, C-type lectin superfamily member 6, dendritic cell immunoreceptor, lectin-like immunoreceptor
Species: human
Products:     CLEC4A

Top Publications

  1. Graham L, Brown G. The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine. 2009;48:148-55 pubmed publisher
    ..This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse ..
  2. Ronninger M, Eklöw C, Lorentzen J, Klareskog L, Padyukov L. Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor. Genes Immun. 2008;9:412-8 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) deficiency is related to development of autoimmune disorders and DCIR gene polymorphisms are associated with rheumatoid arthritis (RA)...
  3. Lorentzen J, Flornes L, Eklöw C, Bäckdahl L, Ribbhammar U, Guo J, et al. Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis Rheum. 2007;56:2620-32 pubmed
    ..Five corresponding human APLEC genes were identified and targeted. The SNP rs1133104 in the dendritic cell immunoreceptor gene (DCIR), and a haplotype including that marker and 4 other SNPs in DCIR and its vicinity showed an ..
  4. Kim J, Kim H, Bae K, Choi D, Nickel D. T1 mapping for liver function evaluation in gadoxetic acid-enhanced MR imaging: comparison of look-locker inversion recovery and B1 inhomogeneity-corrected variable flip angle method. Eur Radiol. 2019;: pubmed publisher
    To compare look-locker inversion recovery (LLIR) and B1 inhomogeneity-corrected variable flip angle T1 mapping methods for estimation of liver function and prediction of hepatic insufficiency and decompensation on gadoxetic ..
  5. Maruhashi T, Kaifu T, Yabe R, Seno A, Chung S, Fujikado N, et al. DCIR maintains bone homeostasis by regulating IFN-γ production in T cells. J Immunol. 2015;194:5681-91 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor mainly expressed in DCs. Dcir (-/-) mice spontaneously develop autoimmune enthesitis and ankylosis accompanied by fibrocartilage proliferation and ectopic ossification...
  6. García Vallejo J, Bloem K, Knippels L, Garssen J, van Vliet S, van Kooyk Y. The Consequences of Multiple Simultaneous C-Type Lectin-Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN. Front Immunol. 2015;6:87 pubmed publisher
    ..adhesion molecule-3-grabbing non-integrin (DC-SIGN), macrophage galactose-type lectin, and dendritic cell immunoreceptor (DCIR)] on different APCs, as well as their intracellular routing...
  7. Do D, Yang S, Yao X, Hamilton R, Schroeder J, Gao P. N-glycan in cockroach allergen regulates human basophil function. Immun Inflamm Dis. 2017;5:386-399 pubmed publisher
    ..An analysis of CLRs revealed the expression of DC-SIGN and DCIR, but not MRC1 and dectin-1, in human basophils...
  8. Matsumoto J, Lohman B, Morimoto K, Ichinose Y, Hattori T, Taira Y. Damage control interventional radiology (DCIR) in prompt and rapid endovascular strategies in trauma occasions (PRESTO): A new paradigm. Diagn Interv Imaging. 2015;96:687-91 pubmed publisher
    ..Damage control interventional radiology (DCIR) is an aggressive and time-conscious algorithm that prioritizes saving life of the hemorrhaging patient in extremis ..
  9. Mfunyi C, Vaillancourt M, Vitry J, Nsimba Batomene T, Posvandzic A, Lambert A, et al. Exosome release following activation of the dendritic cell immunoreceptor: a potential role in HIV-1 pathogenesis. Virology. 2015;484:103-12 pubmed publisher
    ..HIV-1 binds to dendritic cells via dendritic cell immunoreceptor (DCIR)...

More Information


  1. Zhao X, Shen Y, Hu W, Chen J, Wu T, Sun X, et al. DCIR negatively regulates CpG-ODN-induced IL-1β and IL-6 production. Mol Immunol. 2015;68:641-7 pubmed publisher
    ..As antigen-uptake and signaling receptors, CLR modulate immune responses of APC. The dendritic cell immunoreceptor (DCIR) is a member of CLR and has an immunoreceptor tyrosine based inhibitory motif (ITIM) in ..
  2. Klauber T, Laursen J, Zucker D, Brix S, Jensen S, Andresen T. Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines. Acta Biomater. 2017;53:367-377 pubmed publisher
    ..Toll-like receptor (TLR) agonist delivery system comprising liposomes targeted to the dendritic cell immunoreceptor (DCIR)...
  3. Beck M, Velten M, Rybarczyk Vigouret M, Covassin J, Sordet C, Michel B. Analysis and Breakdown of Overall 1-Year Costs Relative to Inpatient and Outpatient Care Among Rheumatoid Arthritis Patients Treated with Biotherapies Using Health Insurance Claims Database in Alsace. Drugs Real World Outcomes. 2015;2:205-215 pubmed
    ..This observational study was conducted in Alsace using 2012 health claims data from the DCIR (Données de Consommation Inter Régime) and PMSI (Programme de Médicalisation des Systèmes d'Information) ..
  4. Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, et al. C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017;114:E540-E549 pubmed publisher
    ..Here, we report that C-type lectin dendritic cell (DC) immunoreceptor (DCIR), a key component in DC homeostasis, is required to modulate lung inflammation and bacterial burden in TB...
  5. Tokieda S, Komori M, Ishiguro T, Iwakura Y, Takahara K, Inaba K. Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis. BMC Immunol. 2015;16:64 pubmed publisher
    ..A murine C-type lectin receptor, dendritic cell immunoreceptor 1 (Dcir1), is expressed on CD11b(+) myeloid cells, such as macrophages, dendritic cells and ..
  6. Kishimoto A, Watanabe M, Terauchi K, Kojima T, Kameda Y, Yamamoto K, et al. Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells. Biochem Biophys Res Commun. 2015;467:383-8 pubmed publisher
    Dendritic cell inhibitory receptor 1 (DCIR1, also known as DCIR and Clec4a2) and dendritic cell activating receptor 2 (DCAR2, also known as DCAR and Clec4b1) are mouse lectin receptors expressed on antigen presenting cells...
  7. Kameda Y, Hanayama M, Kishimoto A, Kume M, Yamamoto K, Matsumoto N. Dendritic cell inhibitory receptor 4 (DCIR4) is preferentially expressed on inflammatory and patrolling monocytes. Biochem Biophys Res Commun. 2016;480:215-221 pubmed publisher
    Dendritic cell inhibitory receptor 4 (DCIR4, Clec4a1) is a lectin receptor and a member of mouse dendritic cell immunoreceptor family. Due to the lack of antibodies against DCIR4, expression of DCIR4 protein remains unknown...
  8. Weng T, Li C, Li C, Hung Y, Yen M, Chang Y, et al. Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo. Mol Ther Nucleic Acids. 2017;9:419-427 pubmed publisher
    b>Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated...
  9. Wolfkamp S, Verstege M, Vogels E, Meisner S, Verseijden C, Stokkers P, et al. Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. Eur J Gastroenterol Hepatol. 2012;24:965-70 pubmed publisher
    ..Functional SNPs in the genes coding for the candidate CLRs DC-SIGN, LLT1, DCIR and MGL were examined. Genotyping of all SNPs was performed at the Academic Medical Center...
  10. Guo J, Wu X, Too C, Yin F, Lu X, He J, et al. A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA - negative RA in a large Asian cohort. PLoS ONE. 2012;7:e41228 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) has been implicated in development of autoimmune disorders in rodent and DCIR polymorphisms were associated with anti-citrullinated proteins antibodies (ACPA)-negative rheumatoid arthritis (RA) in ..
  11. Meyer Wentrup F, Benitez Ribas D, Tacken P, Punt C, Figdor C, de Vries I, et al. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood. 2008;111:4245-53 pubmed publisher
    ..In this study, we demonstrate that, next to the CLR BDCA-2, human pDCs express DC immunoreceptor (DCIR), a CLR with putative immune-inhibitory function, but not dectin-1, mannose receptor, or DC-specific ICAM-3-..
  12. Ebner S, Sharon N, Ben Tal N. Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins. 2003;53:44-55 pubmed
    ..Our analysis also detected patches of conserved residues with yet unknown function(s). ..
  13. Ahmed Z, Kawamura T, Shimada S, Piguet V. The role of human dendritic cells in HIV-1 infection. J Invest Dermatol. 2015;135:1225-1233 pubmed publisher
    ..This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections. ..
  14. Meyer Wentrup F, Cambi A, Joosten B, Looman M, de Vries I, Figdor C, et al. DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production. J Leukoc Biol. 2009;85:518-25 pubmed publisher
    ..To this end, some CLRs, like dectin-1 and dendritic cell immunoreceptor (DCIR), contain intracellular ITIMs or ITAMs...
  15. Bates E, Fournier N, Garcia E, Valladeau J, Durand I, Pin J, et al. APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol. 1999;163:1973-83 pubmed
    We have identified a novel member of the calcium-dependent (C-type) lectin family. This molecule, designated DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate ..
  16. Liu M, Wu X, Liu X, He J, Su Y, Guo J, et al. Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren's syndrome. Hum Immunol. 2015;76:808-11 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) has previously shown an association with rheumatoid arthritis (RA) in Caucasians and Han Chinese...
  17. Klechevsky E, Flamar A, Cao Y, Blanck J, Liu M, O Bar A, et al. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood. 2010;116:1685-97 pubmed publisher
    ..We found the immunoreceptor tyrosine-based inhibitory motif-containing DC immunoreceptor (DCIR) to mediate potent cross-presentation...
  18. Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, et al. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. 2017;47:704-712 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) is a C-type lectin with an immunoreceptor tyrosine-based inhibitory motif (ITIM)...
  19. Huang X, Yuan Z, Chen G, Zhang M, Zhang W, Yu Y, et al. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. Biochem Biophys Res Commun. 2001;281:131-40 pubmed
    ..membrane protein that contains an ITIM proximal to N terminal and is designated as lectin-like immunoreceptor (LLIR). The gene of LLIR is located in a region of chromosomal 12p13 and shows highest homologous with ASGPR...
  20. Jin W, Li C, Du T, Hu K, Huang X, Hu Q. DC-SIGN plays a stronger role than DCIR in mediating HIV-1 capture and transfer. Virology. 2014;458-459:83-92 pubmed publisher
    The C-type lectin receptors (CLRs) expressed on dendritic cells (DCs), in particular DC-SIGN and DCIR, likely play an important role in HIV-1 early infection...
  21. Bloem K, Vuist I, van den Berk M, Klaver E, van Die I, Knippels L, et al. DCIR interacts with ligands from both endogenous and pathogenic origin. Immunol Lett. 2014;158:33-41 pubmed publisher
    ..The carbohydrate specificity of dendritic cell immunoreceptor (DCIR), another DC-expressed lectin, was still debated, but we have recently confirmed DCIR as mannose/..
  22. Graham J, Authie P, Yu C, Zurawski S, Li X, Marches F, et al. Targeting dendritic cells in humanized mice receiving adoptive T cells via monoclonal antibodies fused to Flu epitopes. Vaccine. 2016;34:4857-4865 pubmed publisher
    ..protein-1 (FluM1) antigen fused to human specific antibodies targeting different DC receptors, including DEC-205, DCIR, Dectin-1, and CD40, elicited human CD8(+) T-cell responses, as defined by the magnitude of specific CD8(+) T-cells ..
  23. Richard M, Thibault N, Veilleux P, Gareau Pagé G, Beaulieu A. Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. Mol Immunol. 2006;43:1716-21 pubmed
    ..b>CLECSF6, also called DCIR, is a transmembrane protein expressed on leukocytes and predominantly on neutrophils that bears ..
  24. Richard M, Veilleux P, Rouleau M, Paquin R, Beaulieu A. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. J Leukoc Biol. 2002;71:871-80 pubmed
    ..of the modulation of the expression of inflammation-related genes in neutrophils, we have found a gene called CLECSF6 (C-type lectin superfamily 6). CLECSF6 expresses two mRNA species at low levels in resting neutrophils...
  25. Jiang A, Jiang J, Guo M, Jin Y, Li Y, Wang J. Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells. J Virol. 2015;89:8050-62 pubmed publisher
    ..cell (DC)-specific intercellular adhesion molecule 3 (ICAM3)-grabbing nonintegrin (DC-SIGN), DC immunoreceptor (DCIR), heparan sulfate proteoglycan (HSPG), and α4β7 integrin and mediated the most efficient capture of HIV-1 on ..
  26. Lambert A, Barabé F, Gilbert C, Tremblay M. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. Blood. 2011;117:6589-99 pubmed publisher
    b>Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor expressed at high levels on dendritic cells (DCs). This surface molecule acts as an attachment factor for HIV-1 on DCs and contributes to trans- and cis-infection pathways...
  27. Lambert A, Gilbert C, Richard M, Beaulieu A, Tremblay M. The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis-infection pathways. Blood. 2008;112:1299-307 pubmed publisher
    ..We demonstrate that a cell surface molecule designated DCIR (for DC immunoreceptor), a member of a recently described family of DC-expressing CLRs, can participate in the ..
  28. Richard M, Thibault N, Veilleux P, Breton R, Beaulieu A. The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents. Biochem Biophys Res Commun. 2003;310:767-73 pubmed
    The recently discovered CLECSF6 protein displays the features of a receptor involved in the down-modulation of leukocyte activation...
  29. Drickamer K. C-type lectin-like domains. Curr Opin Struct Biol. 1999;9:585-90 pubmed
    ..C-type lectin-like domains associate with each other through several different surfaces to form dimers and trimers, from which ligand-binding sites project in a variety of different orientations. ..