Gene Symbol: CLDN3
Description: claudin 3
Alias: C7orf1, CPE-R2, CPETR2, HRVP1, RVP1, claudin-3, CPE-R 2, CPE-receptor 2, Clostridium perfringens enterotoxin receptor 2, ventral prostate.1 protein homolog, ventral prostate.1-like protein
Species: human
Products:     CLDN3

Top Publications

  1. Lameris A, Huybers S, Burke J, Monnens L, Bindels R, Hoenderop J. Involvement of claudin 3 and claudin 4 in idiopathic infantile hypercalcaemia: a novel hypothesis?. Nephrol Dial Transplant. 2010;25:3504-9 pubmed publisher
    ..Two of the genes, named CLDN3 and CLDN4, located within this region are members of the claudin family that has been shown to be involved in ..
  2. Hashimoto K, Oshima T, Tomita T, Kim Y, Matsumoto T, Joh T, et al. Oxidative stress induces gastric epithelial permeability through claudin-3. Biochem Biophys Res Commun. 2008;376:154-7 pubmed publisher
    ..This is the first study to demonstrate that claudin-3 is involved in the barrier function of gastric epithelial cells and that rebamipide abolishes the H2O2-induced decrease in claudin-3 protein. ..
  3. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285-93 pubmed
    ..New insights into the molecular architecture of tight junctions allow us to now discuss the structure and functions of this unique cell-cell adhesion apparatus in molecular terms. ..
  4. Santin A, Bellone S, Siegel E, McKenney J, Thomas M, Roman J, et al. Overexpression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas. Clin Cancer Res. 2007;13:3339-46 pubmed
    ..These proteins may offer promising targets for the use of CPE as a novel type-specific therapy against this biologically aggressive variant of endometrial cancer. ..
  5. Katoh M, Katoh M. CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Mol Med. 2003;11:683-9 pubmed
    ..23 CLDN family genes within the human genome, CLDN1 and CLDN16 genes were clustered on human chromosome 3q28, CLDN3 and CLDN4 on 7q11, CLDN6 and CLDN9 on 16p13.3, CLDN8 and CLDN17 on 21q22.11, CLDN21 and CLDN22 on 4q35.1...
  6. Heinzelmann Schwarz V, Gardiner Garden M, Henshall S, Scurry J, Scolyer R, Davies M, et al. Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clin Cancer Res. 2004;10:4427-36 pubmed
    ..The expression patterns of three integral membrane proteins, discoidin domain receptor 1 (DDR1), claudin 3 (CLDN3), and epithelial cell adhesion molecule, all of which are involved in cell adhesion, were evaluated in a ..
  7. de Oliveira S, de Oliveira I, de Souza W, Morgado Diaz J. Claudins upregulation in human colorectal cancer. FEBS Lett. 2005;579:6179-85 pubmed
    ..Whereas the functional significance of claudin overexpression in colorectal cancer is unclear, these proteins can become potential markers and targets in colorectal cancer. ..
  8. Santin A, Bellone S, Marizzoni M, Palmieri M, Siegel E, McKenney J, et al. Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE). Cancer. 2007;109:1312-22 pubmed
    ..The potential for targeting this pathway in the treatment of USPC was explored...
  9. Shang X, Lin X, Alvarez E, Manorek G, Howell S. Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases. Neoplasia. 2012;14:974-85 pubmed
    ..Claudins are required for the formation and maintenance of TJs. Claudin-3 (CLDN3) and claudin-4 (CLDN4) are highly expressed in the majority of ovarian cancers...

More Information


  1. D Souza T, Agarwal R, Morin P. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem. 2005;280:26233-40 pubmed
    ..In addition, our findings may have general implications for the regulation of TJs in normal epithelial cells. ..
  2. Kleinberg L, Holth A, Trope C, Reich R, Davidson B. Claudin upregulation in ovarian carcinoma effusions is associated with poor survival. Hum Pathol. 2008;39:747-57 pubmed publisher
    ..Claudin-3 and claudin-7 expression in effusions independently predicts poor survival in OC. ..
  3. Zhu Y, Brannstrom M, Janson P, Sundfeldt K. Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Int J Cancer. 2006;118:1884-91 pubmed
    ..We found that a weak or absence of expression of claudin 3 and claudin 4 in surface OSE changed to typical cell-border localisation in OSE of inclusion cysts in the normal ..
  4. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 1999;96:511-6 pubmed
    ..Three of these were reported previously as RVP1, Clostridium perfringens enterotoxin receptor, and TMVCF, but their physiological functions were not determined...
  5. Honda H, Pazin M, D Souza T, Ji H, Morin P. Regulation of the CLDN3 gene in ovarian cancer cells. Cancer Biol Ther. 2007;6:1733-42 pubmed
    ..CLDN gene expression is frequently altered in several human cancers, and in particular, CLDN3 and CLDN4 are commonly overexpressed in ovarian cancer...
  6. Huang Y, Bao Y, Peng W, Goldberg M, Love K, Bumcrot D, et al. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci U S A. 2009;106:3426-30 pubmed publisher
    Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. Previous in vitro studies have indicated that CLDN3 overexpression promotes the migration, invasion, and survival of ovarian cancer cells...
  7. Moldvay J, Jackel M, Páska C, Soltesz I, Schaff Z, Kiss A. Distinct claudin expression profile in histologic subtypes of lung cancer. Lung Cancer. 2007;57:159-67 pubmed
  8. Long H, Crean C, Lee W, Cummings O, Gabig T. Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. Cancer Res. 2001;61:7878-81 pubmed
  9. Choi Y, Kim J, Kwon M, Choi J, Kim T, Bae D, et al. Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. Histol Histopathol. 2007;22:1185-95 pubmed publisher
    Tight junction proteins claudin 3 (CLDN3) and claudin 4 (CLDN4) are frequently altered in several human cancers, including ovarian carcinomas...
  10. Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. 1999;147:891-903 pubmed
    ..We concluded that distinct species of claudins can interact within and between TJ strands, except in some combinations. This mode of assembly of claudins could increase the diversity of the structure and functions of TJ strands. ..
  11. Kwon M, Kim S, Choi Y, Jung H, Balch C, Kim S, et al. Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications. Carcinogenesis. 2010;31:974-83 pubmed publisher
    ..During ovarian tumorigenesis, derepression of CLDN3 and CLDN4 expression correlates with loss of H3K27me3 in addition to trimethylated histone H4 lysine 20 (H4K20me3),..
  12. Gonzalez Mariscal L, Betanzos A, Nava P, Jaramillo B. Tight junction proteins. Prog Biophys Mol Biol. 2003;81:1-44 pubmed
  13. Shang X, Lin X, Manorek G, Howell S. Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. Mol Pharmacol. 2013;83:85-94 pubmed publisher
    Claudin-3 (CLDN3) and claudin-4 (CLDN4) are the major structural molecules that form tight junctions (TJs) between epithelial cells...
  14. Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997;272:26652-8 pubmed
    ..classified into two groups, the Vero cell CPE receptor homologues and rat androgen withdrawal apoptosis protein (RVP1; accession no. M74067) homologues, based on the similarities of primary amino acid sequences...
  15. Liu S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:88-105 pubmed publisher
    ..elevated the mRNA levels of tight junction proteins (Occludin, zonula occludens 1, Claudin b, Claudin c and Claudin 3) (P < 0...
  16. Li L, Feng L, Jiang W, Jiang J, Wu P, Zhao J, et al. Dietary pantothenic acid depressed the gill immune and physical barrier function via NF-κB, TOR, Nrf2, p38MAPK and MLCK signaling pathways in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;47:500-10 pubmed publisher
    ..catalase and glutathione S-transferases activities, and liver-expression antimicrobial peptide 2, hepcidin, Claudin 3, Claudin c and Occludin mRNA levels (P < 0.05)...
  17. Jiang W, Feng L, Qu B, Wu P, Kuang S, Jiang J, et al. Changes in integrity of the gill during histidine deficiency or excess due to depression of cellular anti-oxidative ability, induction of apoptosis, inflammation and impair of cell-cell tight junctions related to Nrf2, TOR and NF-?B signaling in fish. Fish Shellfish Immunol. 2016;56:111-122 pubmed publisher
  18. Feng L, Li W, Liu Y, Jiang W, Kuang S, Wu P, et al. Protective role of phenylalanine on the ROS-induced oxidative damage, apoptosis and tight junction damage via Nrf2, TOR and NF-?B signalling molecules in the gill of fish. Fish Shellfish Immunol. 2017;60:185-196 pubmed publisher
    ..05). Furthermore, the results indicated that Phe deficiency decreased Claudin b, Claudin 3, Occludin and ZO-1 transcription and increased Claudin 15 expression in the fish gills (P < 0.05)...
  19. Feng L, Li S, Jiang W, Liu Y, Jiang J, Wu P, et al. Deficiency of dietary niacin impaired intestinal mucosal immune function via regulating intestinal NF-κB, Nrf2 and MLCK signaling pathways in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;49:177-93 pubmed publisher
    ..05). Additionally, niacin deficiency decreased mRNA levels of CuZnSOD, MnSOD, GPx, CAT, GST, GR, Claudin b, Claudin 3, Claudin c, Occludin, ZO-1, Claudin 15 and NF-E2-related factor 2 (Nrf2) (P < 0...
  20. Shi L, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Immunity decreases, antioxidant system damages and tight junction changes in the intestine of grass carp (Ctenopharyngodon idella) during folic acid deficiency: Regulation of NF-κB, Nrf2 and MLCK mRNA levels. Fish Shellfish Immunol. 2016;51:405-419 pubmed publisher
    ..In conclusion, folic acid deficiency (0.1 mg kg(-1)) impaired fish intestinal immunity, antioxidant capacity and tight junctions. ..
  21. Wen L, Feng L, Jiang W, Liu Y, Wu P, Zhao J, et al. Thiamin deficiency induces impaired fish gill immune responses, tight junction protein expression and antioxidant capacity: Roles of the NF-κB, TOR, p38 MAPK and Nrf2 signaling molecules. Fish Shellfish Immunol. 2016;51:373-383 pubmed publisher
    ..Furthermore, thiamin deficiency resulted in reduced mRNA transcript levels of claudin b, claudin 3, claudin 12, zonula occludens 1 (ZO-1) and occludin and increased mRNA transcript levels of claudin 15a, myosin ..
  22. Jiang W, Deng Y, Zhou X, Liu Y, Jiang J, Kuang S, et al. Towards the modulation of oxidative damage, apoptosis and tight junction protein in response to dietary leucine deficiency: A likely cause of ROS-induced gill structural integrity impairment. Fish Shellfish Immunol. 2017;70:609-620 pubmed publisher
    ..the relative mRNA expression of tight junction protein, including occludin, zonula occludens-1, claudin b, claudin 3 and claudin 12 was up-regulated with leucine diet supplementations...
  23. Zeng Y, Jiang W, Liu Y, Wu P, Zhao J, Jiang J, et al. Dietary alpha-linolenic acid/linoleic acid ratios modulate intestinal immunity, tight junctions, anti-oxidant status and mRNA levels of NF-κB p65, MLCK and Nrf2 in juvenile grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;51:351-364 pubmed publisher
    ..78-72.00 g) were estimated to be 1.13 and 1.12, respectively. ..
  24. Wang B, Feng L, Jiang W, Wu P, Kuang S, Jiang J, et al. Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-κB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine. Aquat Toxicol. 2015;158:125-37 pubmed publisher
    ..05). In contrast, the relative mRNA expression levels of occludin, zonula occludens-1 (ZO-1), claudin b, claudin 3, claudin 12, target of rapamycin (TOR) and inhibitor factor κBα (IκBα) in the gills were decreased ..
  25. Chen Y, Jiang W, Liu Y, Jiang J, Wu P, Zhao J, et al. Exogenous phospholipids supplementation improves growth and modulates immune response and physical barrier referring to NF-κB, TOR, MLCK and Nrf2 signaling factors in the intestine of juvenile grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;47:46-62 pubmed publisher
    ..05), and the mRNA relative expression levels of occludin, zonula occludens 1 (ZO-1), claudin 3, claudin 12, claudin b, claudin c, SOD1, GPx, GR and NF-E2-related factor 2 (Nrf2) and decreased malondialdehyde ..
  26. Pradhan Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, et al. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2017;: pubmed publisher
    ..Mice with dual catenin loss develop progressive intrahepatic cholestasis, and hence provides a unique model to study diseases like PFIC. This article is protected by copyright. All rights reserved...
  27. Zhao J, Feng L, Liu Y, Jiang W, Wu P, Jiang J, et al. Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian). Fish Shellfish Immunol. 2014;41:663-73 pubmed publisher
  28. Shukla P, Gangwar R, Manda B, Meena A, Yadav N, Szabó E, et al. Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine. Am J Physiol Gastrointest Liver Physiol. 2016;310:G705-15 pubmed publisher
    ..These data demonstrate that radiation rapidly disrupts TJ, AJ, and the actin cytoskeleton by an oxidative stress-dependent mechanism that can be prevented by NAC feeding. ..
  29. Lopetuso L, Jia R, Wang X, Jia L, Petito V, Goodman W, et al. Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. Inflamm Bowel Dis. 2017;23:392-403 pubmed publisher
    ..Together, these findings represent a potential mechanistic pathway leading to the exacerbation and perpetuation of chronic gut inflammation in experimental ileitis and possibly, in patients with Crohn's disease. ..
  30. Rodenburg R, Snijder J, van de Waterbeemd M, Schouten A, Granneman J, Heck A, et al. Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry. Nat Commun. 2017;8:1280 pubmed publisher
  31. Masili Oku S, Almeida B, Bacchi C, Filassi J, Baracat E, Carvalho F. Lymphocyte-predominant triple-negative breast carcinomas in premenopausal patients: Lower expression of basal immunohistochemical markers. Breast. 2017;31:34-39 pubmed publisher
    ..There was a trend to higher expression of ALDH1 by stromal intratumoral cells. The expression of all other markers were similar in the two groups. Lymphocyte-predominant TNBC in premenopausal patients are mostly of non-basal phenotype. ..
  32. Tokes A, Kulka J, Paku S, Szik A, Páska C, Novák P, et al. Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res. 2005;7:R296-305 pubmed
    ..Altogether, 56 sections from 52 surgically resected breast specimens were analyzed for CLDN1, CLDN3 and CLDN4 expression by immunohistochemistry. mRNA was also analyzed using real-time PCR in 17 of the 52 cases...
  33. Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, et al. Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis. J Invest Dermatol. 2018;138:1279-1287 pubmed publisher
    ..This critical role in water barrier function was confirmed in Cldn3-/- and Cldn3+/- mice and those with experimentally decreased claudin-3...
  34. Ahmad R, Kumar B, Chen Z, Chen X, Muller D, Lele S, et al. Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling. Oncogene. 2017;36:6592-6604 pubmed publisher
    ..Overall, these novel findings identify claudin-3 as a therapeutic target for inhibiting overactivation of Wnt-signaling to prevent CRC malignancy. ..
  35. Cocco E, Deng Y, Shapiro E, Bortolomai I, Lopez S, Lin K, et al. Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells. Mol Cancer Ther. 2017;16:323-333 pubmed publisher
    ..041). p16 DT-A c-CPE-NP may represent a novel dual-targeting therapeutic approach for the selective delivery of gene therapy to chemotherapy-resistant ovarian cancer cells. Mol Cancer Ther; 16(2); 323-33. ©2016 AACR. ..
  36. Kobayashi K, Tsugami Y, Matsunaga K, Oyama S, Kuki C, Kumura H. Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells. Biochim Biophys Acta. 2016;1863:2006-16 pubmed publisher
    ..process of less permeable TJs, MECs show a selective downregulation of Cldn4 and a localization change of Cldn3. To investigate what induces less permeable TJs through these compositional changes in Cldns, we focused on two ..
  37. Mees S, Mennigen R, Spieker T, Rijcken E, Senninger N, Haier J, et al. Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4, and beta-catenin. Int J Colorectal Dis. 2009;24:361-8 pubmed publisher
    ..TJ proteins claudin-1, claudin-3, claudin-4, and the AJ protein beta-catenin are overexpressed in CAC. This suggests that these proteins may become potential markers and targets in CAC. ..
  38. Nava P, Vidal J. The CpAL system regulates changes of the trans-epithelial resistance of human enterocytes during Clostridium perfringens type C infection. Anaerobe. 2016;39:143-9 pubmed publisher
    ..Finally, immunofluorescence studies demonstrate that C. perfringens type C infection redistribute TJs protein occludin, and Claudin-3, and DMs protein desmoglein-2, but did not affect the AJs protein E-cadherin. ..
  39. Xue Y, Zhang H, Sun X, Zhu M. Metformin Improves Ileal Epithelial Barrier Function in Interleukin-10 Deficient Mice. PLoS ONE. 2016;11:e0168670 pubmed publisher
  40. Barmeyer C, Fromm M, Schulzke J. Active and passive involvement of claudins in the pathophysiology of intestinal inflammatory diseases. Pflugers Arch. 2017;469:15-26 pubmed publisher
  41. Jun K, Lee J, Kim S, Jung J, Choi H, Kim Y, et al. Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models. Oncol Rep. 2015;34:2047-53 pubmed publisher
    ..Metformin treatment may be useful for modulating the metastatic capacity by reducing VEGF expression and blocking epithelial-to-mesenchymal transition. ..
  42. Guo X, Zhu D, Lian R, Han Y, Guo Y, Li Z, et al. Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells. Exp Eye Res. 2016;147:37-49 pubmed publisher
    ..This study will benefit the understanding of hRPE cells and future cell therapy. ..
  43. Li J, Xie F, Xu X, Ma J, Zhou D, Liao Y, et al. [Claudin-3 expression in colorectal carcinoma and its significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:63-67 pubmed
    ..Claudin-3 may serve as a molecular biomarker for early diagnosis and prognostic evaluation. ..
  44. Feng L, Gan L, Jiang W, Wu P, Liu Y, Jiang J, et al. Gill structural integrity changes in fish deficient or excessive in dietary isoleucine: Towards the modulation of tight junction protein, inflammation, apoptosis and antioxidant defense via NF-?B, TOR and Nrf2 signaling pathways. Fish Shellfish Immunol. 2017;63:127-138 pubmed publisher
  45. Salden B, Troost F, Wilms E, Truchado P, Vilchez Vargas R, Pieper D, et al. Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial: Arabinoxylans in gut barrier. Clin Nutr. 2018;37:471-480 pubmed publisher
    ..Further studies are required to assess whether such fermentation profile will translate into improved gut barrier function and immune health. The trial has been registered at with study ID number NCT01877044. ..
  46. Jiao N, Wu Z, Ji Y, Wang B, Dai Z, Wu G. L-Glutamate Enhances Barrier and Antioxidative Functions in Intestinal Porcine Epithelial Cells. J Nutr. 2015;145:2258-64 pubmed publisher
    ..These findings indicate that Glu plays an important role in mucosal barrier function by enhancing cell growth and maintaining membrane integrity in response to oxidative stress. ..
  47. Xu R, Li Q, Zhou J, Zhou X, Perelman J, Kolosov V. The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor. Biosci Rep. 2013;33: pubmed publisher
  48. Rolland W, Krafft P, Lekic T, Klebe D, Legrand J, Weldon A, et al. Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups. J Neurochem. 2017;140:776-786 pubmed publisher
    ..Fingolimod treatment improved functional and morphological outcomes after GMH, in part, by tempering acute post-hemorrhagic blood-brain barrier disruption via the activation of the S1PR1/Akt/Rac1 pathway. ..
  49. Li W, Sun K, Ji Y, Wu Z, Wang W, Dai Z, et al. Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells. J Nutr. 2016;146:964-9 pubmed publisher
    ..Supplementation with glycine may provide an effective nutritional strategy to improve intestinal integrity in piglets. ..
  50. Lin Q, Huang P, Tian X, Shang X, Wu Y, Han P, et al. [Effects of the combination of musk and olibanum on the expressions of tight junction proteins in the prostate epithelial cells of rats]. Zhonghua Nan Ke Xue. 2015;21:1110-5 pubmed
  51. Martínez Peña A, Rivera Baños J, Méndez Carrillo L, Ramírez Solano M, Galindo Bustamante A, Páez Franco J, et al. Perinatal administration of bisphenol A alters the expression of tight junction proteins in the uterus and reduces the implantation rate. Reprod Toxicol. 2017;69:106-120 pubmed publisher
  52. Peter A, Fatykhova D, Kershaw O, Gruber A, Rueckert J, Neudecker J, et al. Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment. Histochem Cell Biol. 2017;147:707-719 pubmed publisher
    ..The thereby observed deterioration of lung alveolar junctional organisation gives a structural explanation for alveolar barrier disruption in severe pneumococcal pneumonia. ..
  53. Ando H, Suzuki M, Kato Nakano M, Kawamoto S, Misaka H, Kimoto N, et al. Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells. Biosci Biotechnol Biochem. 2015;79:1272-9 pubmed publisher
    Human claudin-3 (CLDN3) is a tetraspanin transmembrane protein of tight junction structures and is known to be over-expressed in some malignant tumors...
  54. Gilani S, Howarth G, Nattrass G, Kitessa S, Barekatain R, Forder R, et al. Gene expression and morphological changes in the intestinal mucosa associated with increased permeability induced by short-term fasting in chickens. J Anim Physiol Anim Nutr (Berl). 2017;: pubmed publisher
    ..However, all other TJP genes examined were not statistically different from control. Nevertheless, ileal FABP-6 of all fasted groups was significantly reduced, which could possibly be due to reduced bile acid production during fasting...
  55. Daly M, Atkinson S, Varisco B, Klingbeil L, Hake P, Lahni P, et al. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. FASEB J. 2016;30:3453-3460 pubmed
    ..C., Atkinson, S. J., Varisco, B. M., Klingbeil L., Hake, P., Lahni, P., Piraino, G., Wu, D., Hogan, S. P., Zingarelli, B., Wong, H. R. Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion. ..
  56. Aro K, Rosa L, Bello I, Soini Y, Makitie A, Salo T, et al. Expression pattern of claudins 1 and 3-an auxiliary tool in predicting behavior of mucoepidermoid carcinoma of salivary gland origin. Virchows Arch. 2011;458:341-8 pubmed publisher
    ..We conclude that analysis of staining intensities of CLDN 1 and 3 is useful as an auxiliary diagnostic and prognostic tool in patients with salivary gland MEC. ..
  57. Haines R, Beard R, Chen L, Eitnier R, Wu M. Interleukin-1? Mediates ?-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells. Dig Dis Sci. 2016;61:2252-61 pubmed publisher
    ..Taken together, these data represent the first line of evidence demonstrating nmMLCK regulation of claudin-3 expression in response to IL-1?-treated epithelial cells. ..
  58. Konecny G, Agarwal R, Keeney G, Winterhoff B, Jones M, Mariani A, et al. Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer. Gynecol Oncol. 2008;109:263-9 pubmed publisher
    ..Our aim was to determine the expression pattern and prognostic relevance of claudin-3 and claudin-4 in a large cohort of endometrial cancer patients of diverse histological type and stage...
  59. Adams L, Roth M, Abnet C, Dawsey S, Qiao Y, Wang G, et al. Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma. Cancer Prev Res (Phila). 2008;1:357-61 pubmed publisher
    ..Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively...
  60. Winkler L, Gehring C, Wenzel A, M ller S, Piehl C, Krause G, et al. Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem. 2009;284:18863-72 pubmed publisher
    ..The data can be used for the specific design of CPE-based modulators of tight junctions, to improve drug delivery, and as chemotherapeutics for tumors overexpressing claudins...
  61. Li S, Li J, Zhao Y, Zhang Q, Wang Q. Nutrient sensing signaling integrates nutrient metabolism and intestinal immunity in grass carp, Ctenopharyngodon idellus after prolonged starvation. Fish Shellfish Immunol. 2017;71:50-57 pubmed publisher
  62. Dong Y, Feng L, Jiang W, Liu Y, Wu P, Jiang J, et al. Dietary threonine deficiency depressed the disease resistance, immune and physical barriers in the gills of juvenile grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare. Fish Shellfish Immunol. 2018;72:161-173 pubmed publisher
    ..32 g kg-1 diet (4.73 g 100 g-1 protein), 15.52 g kg-1 diet (4.79 g 100 g-1 protein), 15.46 g kg-1 diet (4.77 g 100 g-1 protein), respectively. ..
  63. Heiskala M, Peterson P, Yang Y. The roles of claudin superfamily proteins in paracellular transport. Traffic. 2001;2:93-8 pubmed
  64. Srivastava S, Liew M, McKeon F, Xian W, Yeoh K, Ho K, et al. Immunohistochemical analysis of metaplastic non-goblet columnar lined oesophagus shows phenotypic similarities to Barrett's oesophagus: a study in an Asian population. Dig Liver Dis. 2014;46:170-5 pubmed publisher
    ..Immunostaining for villin, claudin 3 and MUC4 was performed. Statistical analysis was performed and a p value <0.05 was considered significant...
  65. Ionescu Popescu C, Liliac L, Ceauşu R, Balan R, Grigoraş A, Caruntu I, et al. CLDN3 expression and significance - breast carcinoma versus ovarian carcinoma. Rom J Morphol Embryol. 2013;54:99-106 pubmed
    ..We aimed CLDN3 investigation in both breast and ovarian carcinoma, targeting the identification of its expression differences...
  66. Wang H, Yang X. The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues. Int J Clin Exp Pathol. 2015;8:881-7 pubmed
    ..Our present study reveals that claudin-1, -3, and -4 protein expression altered between human gastric cancers and adjacent non-neoplastic tissues. ..
  67. Kooij G, Kopplin K, Blasig R, Stuiver M, Koning N, Goverse G, et al. Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation. Acta Neuropathol. 2014;128:267-77 pubmed publisher
    ..the onset and severity of the disease and in particular address the role of the tight junction protein claudin-3 (CLDN3) in this process...
  68. Sun C, Yi T, Song X, Li S, Qi X, Chen X, et al. Efficient inhibition of ovarian cancer by short hairpin RNA targeting claudin-3. Oncol Rep. 2011;26:193-200 pubmed publisher
    ..New strategies to overcome the therapeutic dilemma are needed. Claudin-3 (CLDN3) is a recently discovered gene generally overexpressed in human ovarian cancers but not in normal ovarian tissue...
  69. Milatz S, Piontek J, Schulzke J, Blasig I, Fromm M, Günzel D. Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3. Biochem J. 2015;468:449-58 pubmed publisher
    ..The data provide novel insight into the molecular TJ architecture consistent with a model with an antiparallel double-row cis-arrangement of classic claudin protomers within strands. ..
  70. Oleinikova N, Kharlova O, Mal kov P, Danilova N. [The expression of claudins in colonic neoplasms]. Arkh Patol. 2017;79:28-35 pubmed publisher
  71. Szakál D, Gyorffy H, Arato A, Cseh A, Molnar K, Papp M, et al. Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch. 2010;456:245-50 pubmed publisher
    ..Increased expressions of CLDN 2 and 3 suggest structural changes of tight junction in coeliac disease which may be, at least in part, responsible for increased permeability and proliferation observed in coeliac disease. ..
  72. Pan X, Li X, Weng Z, Wang B. Altered expression of claudin-3 and claudin-4 in ectopic endometrium of women with endometriosis. Fertil Steril. 2009;91:1692-9 pubmed publisher
    ..Down-regulated expression of claudin-3 and claudin-4 in ectopic endometrium suggests that claudin-3 and claudin-4 might play a pathogenic role in the formation of endometriosis. ..
  73. Mahajan S, Aalinkeel R, Sykes D, Reynolds J, Bindukumar B, Adal A, et al. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 2008;1203:133-48 pubmed publisher
    ..An understanding of the mechanisms of BBB breakdown that lead to neurotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients. ..
  74. Li X, Zhang Y, Wang X, Jin C, Wang Y, Sun T, et al. Regulation of blood-testis barrier assembly in vivo by germ cells. FASEB J. 2017;: pubmed publisher
    ..of inducing Leydig cell testosterone production, which could enhance the expression of integral membrane protein claudin 3 in Sertoli cells...
  75. Schumann S, Buck V, Classen Linke I, Wennemuth G, Grümmer R. Claudin-3, claudin-7, and claudin-10 show different distribution patterns during decidualization and trophoblast invasion in mouse and human. Histochem Cell Biol. 2015;144:571-85 pubmed publisher
    ..We here localized Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8...
  76. Kitayama Y, Fukui H, Hara K, Eda H, Kodani M, Yang M, et al. Role of regenerating gene I in claudin expression and barrier function in the small intestine. Transl Res. 2016;173:92-100 pubmed publisher
    ..REG I deficiency significantly decreased the expression of claudin 3 in the small-intestinal epithelium...
  77. Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999;147:1351-63 pubmed
    ..In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed. ..
  78. Tan S, Duan H, Xun T, Ci W, Qiu J, Yu F, et al. HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy. Lab Invest. 2014;94:777-87 pubmed publisher
    ..Our study highlights the role of HIV-1 in the pathogenesis of HIV/AIDS-related retinopathy and suggests potential therapeutic targets for this ocular complication. ..
  79. Miyoshi Y, Tanabe S, Suzuki T. Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression. Am J Physiol Gastrointest Liver Physiol. 2016;311:G105-16 pubmed publisher
    ..This study shows that intracellular zinc has an essential role in the maintenance of the intestinal epithelial TJ barrier through regulation of occludin proteolysis and claudin-3 transcription. ..
  80. Worst T, von Hardenberg J, Gross J, Erben P, Schnolzer M, Hausser I, et al. Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. Mol Cell Proteomics. 2017;16:998-1008 pubmed publisher
    ..Among the top candidates, we focused on the tight junction protein claudin 3. Retests under serum-free conditions using immunoblotting and immunogold labeling confirmed the presence of ..
  81. Scheurer S, Rybak J, Rösli C, Neri D, Elia G. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics. 2004;4:1737-60 pubmed
    ..g., CXCR4, claudin 3, CD24, tetranectin, Del-1, procollagen lysyl hydroxylase 1 and 2) which are transcriptionally upregulated in ..
  82. Li J, Tu Y, Jiang L, Xu H, Zhang S. [Expression and significance of Snail and Claudin-3 in non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi. 2012;15:583-90 pubmed publisher
    ..05). Snail and Claudin-3 may play important roles in invasion and metastasis in NSCLC, So might be employed to evaluate the prognosis of NSCLC patients. ..
  83. Szathmari A, Jouvet A, Mottolese C, Champier J, Fevre Montange M. Anatomical, molecular and pathological consideration of the circumventricular organs. Neurochirurgie. 2015;61:90-100 pubmed publisher
    ..Furthermore, an immunohistochemical study of Claudin-3 (CLDN3), a membrane protein involved in forming cellular tight junctions, was performed at the level of the SCO...
  84. Kaarteenaho R, Merikallio H, Lehtonen S, Harju T, Soini Y. Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Respir Res. 2010;11:59 pubmed publisher
    ..All claudins studied are linked to the development of airways, whereas claudin-3, -4, -5 and -7, but not claudin-1, are involved in the development of acinus and the differentiation of alveolar epithelial cells. ..
  85. Jiang L, Yang Y, Fu L, Xu W, Liu D, Liang Q, et al. CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma. Oncotarget. 2014;5:7663-76 pubmed
    ..By using genome-wide methylation profiling analysis, we identified CLDN3 as an epigenetically regulated gene in cancer...
  86. Liang X, Zhang X, Han B, Lei W, Qi Q, Wang T, et al. Progesterone and heparin-binding epidermal growth factor-like growth factor regulate the expression of tight junction protein Claudin-3 during early pregnancy. Fertil Steril. 2013;100:1410-8 pubmed publisher
    ..Claudin-3 expression in uterine luminal epithelium is stimulated by P and suppressed by HB-EGF in mice and humans. ..
  87. de Souza W, Fortunato Miranda N, Robbs B, de Araujo W, de Freitas Junior J, Bastos L, et al. Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling. PLoS ONE. 2013;8:e74994 pubmed publisher
    ..In conclusion, our results show a novel role for claudin-3 overexpression in promoting the malignant potential of colorectal cancer cells, which is potentially regulated by the EGF-activated ERK1/2 and PI3K-Akt pathways. ..
  88. Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, et al. Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. J Biol Chem. 2001;276:28204-11 pubmed
    ..These results suggest that claudin recruits all MT-MMPs and pro-MMP-2 on the cell surface to achieve elevated focal concentrations and, consequently, enhances activation of pro-MMP-2. ..
  89. Bai L, Zhang Z, Zhang H, Li X, Yu Q, Lin H, et al. HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study. BMC Infect Dis. 2008;8:77 pubmed publisher
    ..The effects of HIV-1 Tat on barrier function of the RPE may be mediated by ERK MAPK and NF-kappaB activation, which may represent potential targets for novel therapeutic approaches for the retinopathy induced by HIV infection. ..
  90. Satake S, Semba S, Matsuda Y, Usami Y, Chiba H, Sawada N, et al. Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma. Pathol Int. 2008;58:156-63 pubmed publisher
    ..into TMK-1 (Cdx2-negative) GC cells specifically elevated the expression of claudin-3 and claudin-4 at the mRNA (CLDN3, 3.9-fold; CLDN4, 2.8-fold) and protein levels (claudin-3, 8.6-fold; claudin-4, 9...
  91. Tsugami Y, Matsunaga K, Suzuki T, Takanori N, Kobayashi K. Phytoestrogens weaken the blood-milk barrier in lactating mammary epithelial cells by affecting tight junctions and cell viability. J Agric Food Chem. 2017;: pubmed publisher
    ..Additionally, coumestrol and genistein induced apoptosis in MECs. These results indicate that phytoestrogens weaken the blood-milk barrier by directly affecting TJs and the cellular viability of lactating MECs in different ways...