CLCA4

Summary

Gene Symbol: CLCA4
Description: chloride channel accessory 4
Alias: CaCC, CaCC2, caCC-2, calcium-activated chloride channel family member 4, calcium-activated chloride channel protein 2, calcium-activated chloride channel regulator 4, chloride channel regulator 4, chloride channel, calcium activated, family member 4, hCLCA4, hCaCC-2
Species: human

Top Publications

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
  2. doi Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats
    Vinod D Ramteke
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, U P, 243 122, India
    Pharmacol Biochem Behav 91:417-22. 2009
  3. pmc Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
    Kuai Yu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1722-35. 2010
  4. ncbi TMEM16 proteins: the long awaited calcium-activated chloride channels?
    C A Flores
    Centro de Estudios Cientificos CECS, Valdivia, Chile
    Braz J Med Biol Res 42:993-1001. 2009
  5. doi House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia
    Hyung Ju Cho
    Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
    J Cell Biochem 109:1254-63. 2010
  6. pmc A high-throughput data mining of single nucleotide polymorphisms in Coffea species expressed sequence tags suggests differential homeologous gene expression in the allotetraploid Coffea arabica
    Ramon Oliveira Vidal
    Laboratório de Genômica e Expressão, Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, CEP 13083 970, Campinas SP, Brazil
    Plant Physiol 154:1053-66. 2010
  7. ncbi Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    Ricardo de la Fuente
    1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
    Mol Pharmacol 73:758-68. 2008
  8. ncbi Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine
    I Hatip-Al-Khatib
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, P O Box 33, 20027, Denizli, Turkey
    Brain Res 902:108-18. 2001
  9. doi Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline
    John W Funder
    Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
    J Clin Endocrinol Metab 93:3266-81. 2008
  10. ncbi Dynamic sorption of ionizable organic compounds (IOCs) and xylene from water using geomaterial-modified montmorillonite
    M Houari
    Departement of Chemical Engineering, University of Blida, P O Box 270 09000 Blida, Algeria
    J Hazard Mater 147:738-45. 2007

Detail Information

Publications115 found, 100 shown here

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection...
  2. doi Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats
    Vinod D Ramteke
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, U P, 243 122, India
    Pharmacol Biochem Behav 91:417-22. 2009
    ..injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel opener and NPPB, a CaCC blocker. The effect of ivermectin (5, 10, 20 mg/kg i.p. or 50, 100 and 200 microg/rat by i.c.v...
  3. pmc Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
    Kuai Yu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1722-35. 2010
    ..Here we investigated the role of a candidate CaCC protein, bestrophin-2 (Best2), using Best2-/- mice...
  4. ncbi TMEM16 proteins: the long awaited calcium-activated chloride channels?
    C A Flores
    Centro de Estudios Cientificos CECS, Valdivia, Chile
    Braz J Med Biol Res 42:993-1001. 2009
    ..by three independent groups, using different strategies, of TMEM16A as the molecular counterpart of the CaCC is discussed. TMEM16A is part of a family that has 10 other members in mice...
  5. doi House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia
    Hyung Ju Cho
    Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
    J Cell Biochem 109:1254-63. 2010
    ..both a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and a Ca(2+)-activated Cl(-) channel (CaCC) inhibitor. HDM extract also stimulated fluid secretion from porcine airway mucosa...
  6. pmc A high-throughput data mining of single nucleotide polymorphisms in Coffea species expressed sequence tags suggests differential homeologous gene expression in the allotetraploid Coffea arabica
    Ramon Oliveira Vidal
    Laboratório de Genômica e Expressão, Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, CEP 13083 970, Campinas SP, Brazil
    Plant Physiol 154:1053-66. 2010
    ..The assignment of the C. arabica haplotypes to the C. canephora (CaCc) or C...
  7. ncbi Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    Ricardo de la Fuente
    1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
    Mol Pharmacol 73:758-68. 2008
    ..Potent, selective CaCC inhibitors have not been available...
  8. ncbi Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine
    I Hatip-Al-Khatib
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, P O Box 33, 20027, Denizli, Turkey
    Brain Res 902:108-18. 2001
    ..585+/-0.01 fmol/microl), low 5-HT (0.334+/-0.032 fmol/microl) and high DOPAC/DA ratio (265.11+/-20.73) in intact cACC. 6-OHDA alone (8 microg/2 microl) depleted DA (-66%), DOPAC (-65%), and NE (-62%)...
  9. doi Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline
    John W Funder
    Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
    J Clin Endocrinol Metab 93:3266-81. 2008
    ..Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism...
  10. ncbi Dynamic sorption of ionizable organic compounds (IOCs) and xylene from water using geomaterial-modified montmorillonite
    M Houari
    Departement of Chemical Engineering, University of Blida, P O Box 270 09000 Blida, Algeria
    J Hazard Mater 147:738-45. 2007
    ..and fixed-bed column studies were undertaken to evaluate the performance of clay-active coal-coated cement (CACC) in removing phenols from aqueous solution...
  11. pmc In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction
    E C Strauss
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Mol Cell Biol 12:2135-42. 1992
    ..on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon ..
  12. pmc Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
    Wan Namkung
    Department of Medicine, University of California, San Francisco, CA 94143 0521, USA
    FASEB J 24:4178-86. 2010
    TMEM16A was found recently to be a calcium-activated Cl(-) channel (CaCC)...
  13. ncbi Structure of the L-histidine decarboxylase gene
    K Yatsunami
    Japan Tobacco Inc, Pharmaceutical Basic Research Laboratories, Yokohama
    J Biol Chem 269:1554-9. 1994
    ..We found a TATA-like sequence, a GC box, four CACC boxes, four GATA consensus sequences, and six leader-binding protein-1 binding motifs in the promoter region of the ..
  14. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009
    ..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
  15. ncbi myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
    M A Carew
    Inositide Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:26906-13. 2000
    Does inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P(4)) inhibit apical Ca(2+)-activated Cl(-) conductance (CaCC)? We studied this question using human CFPAC-1 pancreatoma cells grown in polarized monolayers...
  16. ncbi Chloride transport in NCL-SG3 sweat gland cells: channels involved
    Z Servetnyk
    Department of Medical Cell Biology, Uppsala University, Box 571, SE 751 23 Uppsala, Sweden
    Exp Mol Pathol 83:47-53. 2007
    ..Ca(2+)-activated chloride conductance is confirmed and the putative Ca(2+)-activated chloride channel (CaCC) is further characterized in term of its pharmacological sensitivity...
  17. ncbi Identification of novel, cardiac-restricted transcription factors binding to a CACC-box within the human cardiac troponin I promoter
    K A Dellow
    Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Cardiovasc Res 50:24-33. 2001
    ..In analysing the putative binding elements within the proximal promoter, a CACC-box sequence overlapping a consensus Sp1 element has been identified...
  18. ncbi Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study
    I Hatip-Al-khati
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Jpn J Pharmacol 87:277-87. 2001
    ..and extracellular amines concentration by 6-hydroxydopamine (6-OHDA)-induced lesion of core nucleus accumbens (cACC) of rats...
  19. ncbi The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression
    C M Li
    Department of Human Genetics, Mount Sinai School of Medicine, New York 10029, USA
    Genomics 62:223-31. 1999
    ..several sequences matching transcription factor binding sites, including nine SP-1 sites, one AP-1 site, and three CACC boxes...
  20. ncbi The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesis
    D Treichel
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 101:175-9. 2001
    ..characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the promoter of many genes...
  21. pmc Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27708, USA
    J Biol Chem 284:14875-80. 2009
    ..CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC...
  22. pmc Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
    Sung Jin Hwang
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 587:4887-904. 2009
    ..Several conductances, such as Ca(2+)-activated Cl() channels (CaCC) and non-selective cation channels (NSCC) have been suggested to be involved in slow wave depolarization...
  23. ncbi Pain dynamics observed by functional magnetic resonance imaging: differential regression analysis technique
    Zang Hee Cho
    Department of Radiological Sciences, University of California, Irvine, California 92697, USA
    J Magn Reson Imaging 18:273-83. 2003
    ..To observe the dynamic responses of the cortical areas related to the pain processing by using the differential regression analysis (DRA) technique in functional magnetic resonance imaging (fMRI) and investigation of pain mechanisms...
  24. pmc Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells
    Victor G Romanenko
    Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 285:12990-3001. 2010
    Activation of an apical Ca(2+)-dependent Cl(-) channel (CaCC) is the rate-limiting step for fluid secretion in many exocrine tissues...
  25. doi Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway
    Lihua Liang
    Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 296:C131-41. 2009
    ..developed a screening assay and screened a library for compounds that could enhance cytoplasmic Ca2+, activate the CaCC, and increase Cl(-) secretion...
  26. ncbi Effect of NYD-SP27 down-regulation on ATP-induced Ca2+-dependent pancreatic duct anion secretion in cystic fibrosis cells
    Jin Xia Zhu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Rm 410, Basic Medical Science Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cell Biol Int 31:521-5. 2007
    ..The inhibitor of adenylate cyclase, MDL12330A (20 microM), and Ca(2+)-dependent Cl(-) channel (CaCC) blocker, DIDS (100 microM) also significantly reduced the basal current in AT-CF...
  27. ncbi Environmental factors promoting the effective use of a computer-assisted clinical case for second-year osteopathic medical students
    R W Baer
    Department of Physiology, Kirksville College of Osteopathic Medicine, USA
    J Am Osteopath Assoc 98:380-5. 1998
    Computer-aided clinical cases (CACC) have the potential to complement and/or supplement other types of problem-based learning exercises in modern medical curricula...
  28. doi Cloning and characterization of a calcium-activated chloride channel in rat uterus
    Junfang Song
    Institute of Genetics and Developmental Biology and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Biol Reprod 80:788-94. 2009
    ..in regulation of uterine contractility, we cloned a novel calcium-activated chloride channel gene, named rat Clca4, from pregnant rat uterus...
  29. pmc Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
    N S Nanda Kumar
    Depts of Biochemistry and Microbiology, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Gastrointest Liver Physiol 299:G707-14. 2010
    ..acid, whereas it was only partially inhibited by CFTR [CFTR(inh)-172, glibenclamide]- and CaCC (niflumic acid)-specific Cl(-) channel blockers...
  30. ncbi Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene
    J F Medina
    Department of Medicine, University Clinic and Medical School, University of Navarra, Pamplona, Spain
    Genomics 39:74-85. 1997
    ..These features, as well as the presence of several consensus elements such as GATA, LBP-1, E-box, CACC box, and T-antigen motif, indicate that the human AE2 promoter resembles the erythroid promoter of the human AE1 ..
  31. doi Biomarkers of human gastrointestinal tract regions
    Elena Maria Comelli
    Department of Nutrition and Health, Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Mamm Genome 20:516-27. 2009
    ..These include CLCA4 and SLC26A2, both implicated in ion transport...
  32. pmc EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2
    Michael R Tallack
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia
    J Biol Chem 284:20966-74. 2009
    ..We found and validated novel intronic enhancers in both the E2f2 and E2f4 genes, which contain conserved CACC, GATA, and E-BOX elements. The E2f2 enhancer was occupied by EKLF in vivo...
  33. ncbi Expression and biological significance of Ca2+-activated ion channels in human keratinocytes
    H Koegel
    Department of Physiology, University of Munich, D 80336 Munich, Germany
    FASEB J 15:145-154. 2001
    ..data, RT-PCR showed that HaCaT keratinocytes express two types of Ca2+-activated Cl- channels, CaCC2 and CaCC3 (CLCA2), as well as the Ca2+-activated K+ channel hSK4...
  34. pmc A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter
    Chang Yun Gui
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:7009-14. 2003
    ..In contrast, promoter hyperacetylation requires the promoter GATA-1, and CACC-factor activator motifs, as well as the TATA box...
  35. ncbi SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population
    William T Wright
    Centre for Clinical and Population Science, Queen s University, Belfast BT9 7AB, UK
    Atherosclerosis 185:353-60. 2006
    ..102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26)...
  36. ncbi Construction of pDESTR, a GATEWAY vector for gene disruption in filamentous fungi
    Ayumi Abe
    Laboratory of Applied Microbiology, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, 060 8589, Japan
    Curr Microbiol 52:210-5. 2006
    ..After the amplification with a 5'CACC-tagged primer and an ordinary primer, the DNA fragment will be inserted into pENTR/D-TOPO vector and then ..
  37. doi TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability
    Ta To Tran
    Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    J Cell Physiol 229:181-90. 2014
    ..TMEM16E did not exhibit cell surface calcium-dependent chloride channel (CaCC) activity, which was originally identified in TMEM16A and TMEM16B, due to their intracellular vesicle distribution...
  38. pmc Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels
    Hiroyuki Terashima
    Departments of Anesthesiology, Physiology and Biophysics, and Biochemistry, Weill Cornell Medical College, Cornell University, New York, NY 10065
    Proc Natl Acad Sci U S A 110:19354-9. 2013
    ..Well-characterized CaCC blockers inhibit Cl(-) transport with Kis comparable to those measured for native and heterologously expressed ..
  39. ncbi Specificity of mammalian Y-box binding protein p50 in interaction with ss and ds DNA analyzed with generic oligonucleotide microchip
    O A Zasedateleva
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, 119991 Moscow, Russian Federation
    J Mol Biol 324:73-87. 2002
    ..The binding of p50 to the generic microchip was shown to be the most specific to ss GGGG motif and then to ss CACC and CATC motifs...
  40. pmc Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle
    George Gallos
    Dept of Anesthesiology, 622 W 168th St P and S Box 46, Columbia Univ College of Physicians and Surgeons, New York, NY 10032
    Am J Physiol Lung Cell Mol Physiol 305:L625-34. 2013
    ..Although calcium-activated chloride channel (CaCC) flux has been described in many cell types, including human airway smooth muscle (HASM), the true molecular ..
  41. ncbi Role of Ca2+-activated Cl- channels in the mechanism of apoptosis induced by cyclosporin A in a human hepatoma cell line
    Jung Ae Kim
    College of Pharmacy, Yeungnam University, Gyongsan 712 749, South Korea
    Biochem Biophys Res Commun 309:291-7. 2003
    ..Treatment with these CaCC inhibitors (NA, FA, NPPB, and DIDS) markedly prevented the CsA-induced apoptosis...
  42. ncbi Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium
    Hazel Atherton
    Novartis Respiratory Research Centre, Wimblehurst Road, Horsham, West Sussex, UK
    Naunyn Schmiedebergs Arch Pharmacol 367:214-7. 2003
    ..short circuit current (ISC) and the appearance of an enhanced calcium-activated chloride conductance (CaCC)...
  43. pmc Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist
    Wan Namkung
    College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406 840, Korea
    Mol Pharmacol 84:384-92. 2013
    ..synthetic small molecules revealed an amino-carbonitrile-pyrazole, C(act)-A1, that activated CFTR but not CaCC Cl⁻ conductance...
  44. pmc A simple method for the preparation of crude gintonin from ginseng root, stem, and leaf
    Mi Kyung Pyo
    International Ginseng and Herb Research Institute, Guemsan 312 804, Korea
    J Ginseng Res 35:209-18. 2011
    ..the effects of crude gintonin from ginseng root, stem, and leaf on endogenous Ca(2+)-activated Cl- channel (CaCC) activity of Xenopus oocytes through mobilization of [Ca(2+)]i...
  45. doi Ca2+-activated Cl- channels
    Loretta Ferrera
    Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy
    Compr Physiol 1:2155-74. 2011
    ..In epithelial cells, CaCC activity mediates the secretion of Cl(-) and of other anions, such as bicarbonate and thiocyanate...
  46. doi Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation
    Juraj Rievaj
    Pulmonary Research Group, Department of Medicine, University of Alberta, 550 Heritage Medical Research Center, Edmonton, Alberta, Canada
    Pflugers Arch 463:497-509. 2012
    ..inhibitor indomethacin and largely blocked (>80%) by niflumic acid, a calcium-activated chloride channels' (CaCC) blocker. Allergic mice also showed an enhanced response to ATP and thapsigargin...
  47. doi The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels
    Paolo Scudieri
    Laboratory of Molecular Genetics, Istituto Giannina Gaslini, 16147 Genova, Italy
    Exp Physiol 97:177-83. 2012
    ..A close paralogue of TMEM16A, TMEM16B (anoctamin-2), is also associated with CaCC activity, although with different properties...
  48. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...
  49. pmc Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity
    Hui Sun
    Division of Pulmonary and Critical Care Medicine, 5501, Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 590:3507-21. 2012
    ..The Ca(2+)-activated Cl(-) channel (CaCC), recently identified as TMEM16A, plays important roles in pulmonary vascular function...
  50. doi δ-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channels
    Daniela da Fonseca Pacheco
    Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais School of Biological Sciences and Health, University Center Newton Paiva, Belo Horizonte, Brazil
    J Pharm Pharmacol 64:1084-9. 2012
    ..The aim of this study was to determine whether Ca(2+)-activated Cl(-) channels (CaCCs) are involved in central antinociception induced by the activation of µ-, δ- and κ-opioid receptors...
  51. pmc Best1 is a gene regulated by nerve injury and required for Ca2+-activated Cl- current expression in axotomized sensory neurons
    Mathieu Boudes
    INSERM, Montpellier, France
    J Neurosci 29:10063-71. 2009
    We investigated the molecular determinants of Ca(2+)-activated chloride current (CaCC) expressed in adult sensory neurons after a nerve injury...
  52. pmc Functional roles of bestrophins in ocular epithelia
    Alan D Marmorstein
    Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85711, USA
    Prog Retin Eye Res 28:206-26. 2009
    ..Thus, the purported CaCC function of the bestrophins and how loss of this function relates to clinical disease needs to be reassessed...
  53. pmc Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
    Wan Namkung
    Department of Medicine and Physiology, University of California, San Francisco, California 94143 0521, USA
    FASEB J 25:4048-62. 2011
    TMEM16A (ANO1) is a calcium-activated chloride channel (CaCC) expressed in secretory epithelia, smooth muscle, and other tissues...
  54. doi Complex adaptive chronic care - typologies of patient journey: a case study
    Carmel M Martin
    National Digital Research Centre, Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland
    J Eval Clin Pract 17:520-4. 2011
    Complex adaptive chronic care (CACC) is a framework based upon complex adaptive systems' theory developed to address different stages in the patient journey in chronic illness...
  55. pmc Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate
    Zachary M Sellers
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    J Physiol 588:2417-29. 2010
    ..mice requires the activation of Ca(2+)/calmodulin-dependent kinase II (CaMKII) and Ca(2+)-activated Cl(-) channels (CaCC) because simultaneous addition of myristoylated-autocamtide-2-related inhibitory peptide or niflumic acid and CFTR(..
  56. doi A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene
    Tasuku Saito
    Division of Pediatrics, University of Tokyo Hospital, Tokyo, Japan
    Bone 49:913-6. 2011
    ..exon 21 of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene responsible for ARHR2 (IVS21+1_3(GTA>CACC))...
  57. pmc ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification
    Aaron B Stephan
    Department of Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 106:11776-81. 2009
    ..However, the molecular identity of the olfactory calcium-activated chloride channel (CaCC) is unknown...
  58. doi Anoctamins
    Karl Kunzelmann
    Institut fur Physiologie, Universitat Regensburg, Universitätsstraße 31, Regensburg, Germany
    Pflugers Arch 462:195-208. 2011
    Endogenous Ca(2+)-activated Cl(-) channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC...
  59. pmc ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
    C Ayoub
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS UDS U 964 INSERM, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, Graffenstaden, France
    Br J Cancer 103:715-26. 2010
    Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC).
  60. doi Direct or indirect regulation of calcium-activated chloride channel by calcium
    Yafei Chen
    School of Sciences, Hebei University of Technology, Tianjin 300130, China
    J Membr Biol 240:121-9. 2011
    ..transmembrane 16A (TMEM16A) was demonstrated by three independent research groups to be a strong candidate for the CaCC molecular basis...
  61. doi Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models
    Josephine Braun
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Cyst Fibros 9:351-64. 2010
    ..the hypothesis that other factors modulate the phenotype including "alternative" calcium-activated anion currents (CaCC)...
  62. pmc CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype
    Horst Fischer
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Am J Physiol Lung Cell Mol Physiol 299:L585-94. 2010
    ..importance of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCC) in Cl secretion by mucous and serous cells of human airway glands...
  63. doi CFTR and TMEM16A are separate but functionally related Cl- channels
    Jiraporn Ousingsawat
    Institut fur Physiologie, Universitat Regensburg, Universitätsstraße 31, Regensburg, Germany
    Cell Physiol Biochem 28:715-24. 2011
    ..relationship of the cystic fibrosis transmembrane conductance regulator (CFTR) and Ca(2+) activated Cl(-) channels (CaCC)...
  64. pmc TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells
    Boris Manoury
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Physiol 588:2305-14. 2010
    ..in primary cultures of rat PASMCs, with small interfering RNAs, was accompanied by almost total loss of whole-cell CaCC currents...
  65. pmc TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells
    Wan Namkung
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 286:2365-74. 2011
    TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We developed pharmacological tools to investigate the contribution of TMEM16A to CaCC conductance in human airway and intestinal epithelial cells...
  66. pmc Inward-rectifier chloride currents in Reissner's membrane epithelial cells
    Kyunghee X Kim
    Cellular Biophysics Laboratory, Kansas State University, Dept of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506 5802, USA
    Biochem Biophys Res Commun 394:434-8. 2010
    ..Channel transcripts expressed include ClC-2, Slc26a7 and ClC-Ka, but not Cftr, ClC-1, ClCa1, ClCa2, ClCa3, ClCa4, Slc26a9, ClC-Kb, Best1, Best2, Best3 or the beta-subunit of ClC-K, barttin...
  67. doi Neural substrates of implicit cueing effect on prospective memory
    Teruo Hashimoto
    Riken BSI Symbolic Cognitive Development, Wako, Saitama, Japan
    Neuroimage 54:645-52. 2011
    ..We found increased caudal anterior cingulate cortex (cACC) activity during the ongoing task with both implicit target and action cues, suggesting that alertness or ..
  68. doi Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia
    Igor Oliynyk
    Orebro University, Orebro University Hospital, Sweden
    APMIS 118:982-90. 2010
    ..It has been proposed that duramycin may stimulate chloride secretion through Ca²(+) -activated Cl⁻ channels (CaCC)...
  69. pmc Studies on expression and function of the TMEM16A calcium-activated chloride channel
    Fen Huang
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:21413-8. 2009
    Calcium-activated chloride channels (CaCC) with similar hallmark features are present in many cell types and mediate important physiological functions including epithelial secretion, sensory signal transduction, and smooth muscle ..
  70. pmc New horizons in the treatment of cystic fibrosis
    A W Cuthbert
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Br J Pharmacol 163:173-83. 2011
    ..to CF can be considered is to recruit alternative chloride channels, such as calcium-activated chloride channel (CaCC), to act as surrogates for CFTR...
  71. pmc Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease
    Charles G Danko
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA
    BMC Med Genomics 2:31. 2009
    ..motif discovery tools revealed that genes in the contractile module were found to contain a TATA-box followed by a CACC-box, and are depleted in other GC-rich motifs; whereas genes in the translation module contain a pyrimidine-rich ..
  72. ncbi Structure and expression of a smooth muscle cell-specific gene, SM22 alpha
    J Solway
    Department of Medicine, University of Chicago, Illinois 60637, USA
    J Biol Chem 270:13460-9. 1995
    ..DNA sequence analyses revealed that the 441-base pair promoter contains two CArG/SRF boxes, a CACC box, and one potential MEF-2 binding site, cis-acting elements which are each important regulators of striated ..
  73. ncbi Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene
    C Rahuel
    INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Immunogenetics 50:271-7. 1999
    ..As in the human, the mouse Lu gene is organized in 15 exons. The proximal promoter showed consensus CACC-binding sites whereas the distal promoter exhibits a GATA-1-binding site and multiple E boxes...
  74. ncbi Use of a computer-assisted clinical case (CACC) SOAP note exercise to assess students' application of osteopathic principles and practice
    N R Chamberlain
    Department of Microbiology Immunology, Kirksville College of Osteopathic Medicine, MO 63501, USA
    J Am Osteopath Assoc 100:437-40. 2000
    ..students' application of osteopathic principles and practice, a Web-based computer-assisted clinical case (CACC) was designed, for which students were required to submit a SOAP (Subjective, Objective, Assessment, Plan) note...
  75. pmc Molecular characterisation of pancreatic zymogen granule ion channel and regulator proteins involved in exocytosis
    F Thevenod
    Department of Physiology, Universitat des Saarlandes, Homburg Saar, Germany
    J Korean Med Sci 15:S51-2. 2000
    ..is blocked by micromolar H2-DIDS or DTT, reminiscent of a family of epithelial Ca(2+)-activated Cl -channels (CaCC)...
  76. ncbi Electrophysiological characteristics of the Ca2+-activated Cl- channel family of anion transport proteins
    C M Fuller
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    Clin Exp Pharmacol Physiol 27:906-10. 2000
    1. A protein isolated from the bovine tracheal epithelium behaves as a Ca2+-activated Cl- channel (CaCC) when incorporated into planar lipid bilayers. 2...
  77. ncbi Ca(2+)-activated Cl(-) channels: a newly emerging anion transport family
    C M Fuller
    Department of Physiology and Biophysics, University of Alabama at Birmingham, MCLM 830, 1918 University Boulevard, Birmingham, AL 35294, USA
    Pflugers Arch 443:S107-10. 2001
    ..to a protein previously isolated from bovine tracheal epithelium that acts as a Ca(2+)-sensitive Cl(-) channel (CaCC) when heterologously expressed or when reconstituted into planar lipid bilayers...
  78. pmc Regulation of murine airway surface liquid volume by CFTR and Ca2+-activated Cl- conductances
    Robert Tarran
    Cystic Fibsosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Gen Physiol 120:407-18. 2002
    ..roles in airway hydration: (1) CFTR, which is cAMP regulated and (2) the Ca(2+)-activated Cl(-) conductance (CaCC) whose molecular identity is uncertain...
  79. ncbi Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia
    Marcus Mall
    Department of Pediatrics and Adolescent Medicine, Albert Ludwigs University, Freiburg, Germany
    Pediatr Res 53:608-18. 2003
    Human airway epithelia express Ca2+-activated Cl- channels (CaCC) that are activated by extracellular nucleotides (ATP and UTP). CaCC is preserved and seems to be up-regulated in the airways of cystic fibrosis (CF) patients...
  80. ncbi Activation of myelin genes during transdifferentiation from melanoma to glial cell phenotype
    Shalom G Slutsky
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:8960-8. 2003
    ..In addition, however, we show that a C/G-rich CACC box in the Po promoter is required for activation by IL6RIL6, as well as by ectopic Sox10, and identify a Kruppel-..
  81. pmc A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
    S Philipsen
    Department of Cell Biology, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands and
    Nucleic Acids Res 27:2991-3000. 1999
    One of the most common regulatory elements is the GC box and the related GT/CACC box, which are widely distributed in promoters, enhancers and locus control regions of housekeeping as well as tissue-specific genes...
  82. ncbi CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
    ..within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies...
  83. ncbi Localization and characterization of the mouse alpha-globin locus control region
    M F Kielman
    Department of Human Genetics, Leiden University, The Netherlands
    Genomics 21:431-3. 1994
    ..However, three of four CACC boxes and one GATA-1 binding site, identified in the human alpha-LCR, are not conserved in the mouse...
  84. ncbi Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene
    M Watanabe
    The Third Department of Internal Medicine, University of Tokyo, Japan
    Circ Res 78:978-89. 1996
    ..Double-stranded oligonucleotides containing either the CACC box or the Sp1 consensus sequence efficiently competed with the CCTCCC elements for binding the nuclear extracts...
  85. ncbi Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes
    P Hermand
    INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Blood 87:2962-7. 1996
    ..The 5'UT region (nucleotides -289 to +9) includes potential binding sites for various transcription factors (Ets, CACC, SP1, GATA-1, AP2) and exhibited a significant transcriptional activity after transfection in the erythroleukemic ..
  86. ncbi Kinetic and pharmacological properties of the calcium-activated chloride-current in macrovascular endothelial cells
    B Nilius
    Laboratorium voor Fysiologie, KU Leuven, Belgium
    Cell Calcium 22:53-63. 1997
    ..RT-PCR experiments did not provide any evidence that the endothelial Ca(2+)-activated Cl- channel might be identical with a recently cloned Ca(2+)-sensitive Cl- channel (CaCC).
  87. pmc Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region
    R Tewari
    Sars International Centre for Molecular Marine Biology, Bergen High Technology Centre, Thormohlensgt 55, N 5020 Bergen, Norway
    EMBO J 17:2334-41. 1998
    ..Thus, EKLF is thought to be a stage-specific factor acting through the CACC box in the beta-gene promoter, even though it is already present in embryonic red cells...
  88. ncbi Characterization of a murine gene homologous to the bovine CaCC chloride channel
    L Romio
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genoa 16148, Italy
    Gene 228:181-8. 1999
    The bovine CaCC protein is a putative Ca2+-dependent Cl- channel of airway epithelial cells. Therefore, CaCC proteins could contribute to transepithelial Cl- transport and accordingly modify the phenotype of cystic fibrosis (CF) patients...
  89. ncbi RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter
    L G Tillotson
    Division of Digestive Diseases and Nutrition, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:8123-8. 1999
    ..Previous studies have shown that a CACC cis-regulatory element is important for transcriptional activation in pancreatic insulinoma cells...
  90. ncbi The CACC box and myocyte enhancer factor-2 sites within the myosin light chain 2 slow promoter cooperate in regulating nerve-specific transcription in skeletal muscle
    K Esser
    School of Kinesiology, University of Illinois at Chicago, Illinois 60608, USA
    J Biol Chem 274:12095-102. 1999
    ..Three sites within the proximal promoter (myocyte enhancer factor-2 (MEF2), E-box, and CACC box) were individually mutated, and the effect on luciferase expression was determined...
  91. ncbi Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF
    Peying Fong
    Department of Physiology, The Johns Hopkins University School of Medicine, Rm 202C Physiology, 725 North Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 285:C433-45. 2003
    Pancreatic duct cells express a Ca2+-activated Cl- conductance (CaCC), upregulation of which may be beneficial to patients with cystic fibrosis...
  92. ncbi Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation
    Cornelis F M Sier
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cancer 109:900-8. 2004
    ..Complement assisted cellular cytotoxicity (CACC) was not detectable, although the iC3b ligand and CR3 receptor were present on respectively target and effector ..
  93. ncbi Perioperative stress response to carotid endarterectomy: the impact of anesthetic modality
    Massimiliano M Marrocco-Trischitta
    Department of Vascular Surgery, San Raffaele Hospital IRCCS, Vita Salute University, Viale Cassiodoro 12, 20145 Milan, Italy
    J Vasc Surg 39:1295-304. 2004
    ..Our aim was to determine the degree of surgical trauma caused by CEA and to define differences related to the use of locoregional or general anesthesia...
  94. ncbi Erythroid Kruppel-like factor regulates the G1 cyclin dependent kinase inhibitor p18INK4c
    Michael R Tallack
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, 4072, Australia
    J Mol Biol 369:313-21. 2007
    ..factor (EKLF, KLF1) is an essential erythroid cell specific C(2)H(2) zinc finger transcription factor that binds CACC box elements in promoters and distant regulatory elements to activate transcription...
  95. ncbi [BTEB/KLF9 and its transcriptional regulation]
    Ling Kang
    Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Yi Chuan 29:515-22. 2007
    ..BTEB regulates transcription through its carboxyl-terminal C2H2 zinc finger motif binding to GC or GT/CACC box, a sort of cis-acting elements, which is wildly distributed in promoters, enhancers and control regions of many ..
  96. ncbi Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells
    Sandrine Dulong
    Laboratoire de Physiologie Cellulaire et Moleculaire, Universite de Nice Sophia Antipolis, Nice, France
    Cell Physiol Biochem 20:483-94. 2007
    ..A pharmacological characterization of those two I(sc) components showed the involvement of CaCC and CFTR channel activity in I(fast) and I(late) respectively...
  97. doi Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline
    Kathryn A Martin
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1105-20. 2008
    ..Our objective was to develop clinical practice guidelines for the evaluation and treatment of hirsutism in premenopausal women...
  98. pmc Endogenous ATP release inhibits electrogenic Na(+) absorption and stimulates Cl (-) secretion in MDCK cells
    Yi Xie
    Department of Physiology and Biophysics, and Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA
    Purinergic Signal 4:125-37. 2008
    ..CFTR) and a 4, 4'-diisothiocyano-2, 2'-disulfonic acid stilbene (DIDS)-sensitive Ca(2+)-activated Cl(-) channel (CaCC)...
  99. doi Comparative functional analysis of the cow and mouse myostatin genes reveals novel regulatory elements in their upstream promoter regions
    David L Allen
    Department of Integrative Physiology, University of Colorado, Boulder, Campus Box 354, Boulder, CO 80309, USA
    Comp Biochem Physiol B Biochem Mol Biol 150:432-9. 2008
    ..Mutagenesis of the TATA, CACC, and AT1 sequences of the mouse to those of the cow significantly decreased activity of the mouse myostatin ..
  100. doi EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src
    Claudette Jeulin
    Laboratoire de Cytophysiologie et Toxicologie Cellulaire, Case Courrier 7073, 3ème étage, T53 54, Universite Paris 7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
    Am J Physiol Lung Cell Mol Physiol 295:L489-96. 2008
    ..line) an endogenous calcium- and voltage-dependent, outwardly rectifying small-conductance chloride channel (CACC), and we examined the effects of EGF on CACC activity...
  101. doi Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells
    Caroline Norez
    Institut de Physiologie et Biologie Cellulaires Université de Poitiers CNRS, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    Eur J Pharmacol 592:33-40. 2008
    ..EC50=831 nM) a DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid) sensitive and Ca2+ dependent Cl- channel (CaCC). Guanabenz activated a linear Cl- channel with unitary single-channel conductance of 8 pS...

Research Grants76

  1. REGULATION OF CHLORIDE ION CONDUCTANCE IN PANCREAS DUCT
    Calvin Cotton; Fiscal Year: 2002
    ..The rationale for this approach rests upon the observation that Ca2+-activated C1-conductance (CACC) is preserved in human CF airway epithelia and that organ-specific disease severity in the CF knockout mouse is ..
  2. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..the transcription factor Sox-2; an octamer binding motif, which binds the transcription factor Oct-3; and a GT/CACC box, which binds the transcription factors Spi and Sp3...
  3. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    Ruth Salo; Fiscal Year: 2009
    ..examined: 1) dorsolateral prefrontal cortex (DLPFC); 2) Rostral; and 3) Caudal anterior cingulate cortex (rACC and cACC); as well as 4) a control region the primary visual cortex (PVC)...
  4. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2010
    ..be examined: 1) dorsolateral prefrontal cortex (DLPFC);2) Rostral;and 3) Caudal anterior cingulate cortex (rACC and cACC);as well as 4) a control region the primary visual cortex (PVC)...
  5. NEURAL AND MECHANICAL REGULATION OF SLOW MYOSIN
    Karyn Esser; Fiscal Year: 2004
    ..Further analyses have identified that the CACC and MEF2 sites within this 270 bp region cooperate in regulating transcription in response to slow innervation...
  6. Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study
    Ruth Salo; Fiscal Year: 2007
    ..via MRS within Dorsolateral Prefrontal White Matter [WM], Rostral and Caudal Anterior Cingulate Cortex [rACC and cACC] as well as a control region the mesial occipital cortex...
  7. RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATER
    James Schafer; Fiscal Year: 2002
    ..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
  8. Depth-resolved imaging of myocardial excitation
    Arkady M Pertsov; Fiscal Year: 2010
    ..The new technology will help to understand the mechanisms of initiation of such sources, which is the key to developing effective anti-arrhythmic therapies and prevention of sudden cardiac death. ..
  9. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
    ..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..
  10. BESTROPHIN AND RETINAL DISEASE
    Alan D Marmorstein; Fiscal Year: 2011
    ..This led to the hypothesis that Best1 is a Ca2+ activated Cl- channel (CaCC) that generates the LP, and that BVMD results from loss of Best1 CaCC activity...
  11. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
    ..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..
  12. Matrix Metalloproteinases, Exercise, and Muscle Damage
    David Allen; Fiscal Year: 2007
    ..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
  13. The Human PFC Response to Drug Cues: Outcome Representation vs. Cognitive Contro
    Stefan Ursu; Fiscal Year: 2007
    ....
  14. BESTROPHIN AND RETINAL DISEASE
    Alan Marmorstein; Fiscal Year: 2007
    ..In the third specific aim we will use a novel human RPE culture system to perform studies in Ussing chambers to assess the cellular consequences of bestrophin dysfunction. ..
  15. REGULATION OF CALCIUM-ACTIVATED CHLORIDE CHANNELS
    H Hartzell; Fiscal Year: 2007
    ..This aim will establish the role of CaC channels and bestrophins in kidney physiology and disease. ..
  16. TRAINING IN MOLECULAR AND CELL BIOLOGY OF CANCER
    BENDICHT PAULI; Fiscal Year: 2007
    ..Specialized support facilities are provided by the Cornell Biotechnology Program, computer facilities, center for research animal resources (including mouse transgenic facilities), and library system. ..
  17. 3D Imaging of electrical activity in myocardial tissue
    Arkady Pertsov; Fiscal Year: 2007
    ..Successful completion of this project will break ground for a new technology, the 3D imaging of electrical activation in the heart. ..
  18. ORGAN-SPECIFIC VASCULAR ARREST OF MALIGNANT CELLS
    BENDICHT PAULI; Fiscal Year: 1990
    ..The uncovering of these mechanisms may allow us to eventually design and develop new approaches for interfering with this process and specifically targeting agents to organ sites at predictable risk for metastatic involvement...
  19. BESTROPHIN AND RETINAL DISEASE
    Alan Marmorstein; Fiscal Year: 2003
    ..abstract_text> ..
  20. Chloride Signaling
    H Hartzell; Fiscal Year: 2003
    ..in the roles of chloride in membrane trafficking, neuroscientists interested in the signaling of chloride channels, transport physiologists involved in ion homeostasis, and geneticists interested in channelopathies ..
  21. ORGAN-SPECIFIC VASCULAR ARREST OF MALIGNANT CELLS
    BENDICHT PAULI; Fiscal Year: 1993
    ..The ultimate goal of these studies is to exploit our understanding of the molecular mechanisms of tumor cell/endothelial cell interactions for the development of new anti-metastatic treatment strategies...
  22. ORGAN SPECIFIC VASCULAR ARREST OF MALIGNANT CELLS
    BENDICHT PAULI; Fiscal Year: 1999
    ..g., anti-Lu-ECAM-1 monoclonal or polyclonal antibodies;synthetic peptides [or carbohydrates] directed against the binding domains; Lu- ECAM-1 anti-sense oligonucleotides). ..
  23. ORGAN-SPECIFIC VASCULAR ARREST OF MALIGNANT CELLS
    BENDICHT PAULI; Fiscal Year: 2002
    ..Understanding the molecular principles that govern extravasation will ultimately allow us to develop strategies in anti-metastatic therapies. ..