Clathrin Heavy Chain


Gene Symbol: Clathrin Heavy Chain
Description: clathrin heavy chain
Alias: CHC, CHC17, CLH-17, CLTCL2, MRD56, clathrin heavy chain 1, clathrin heavy chain on chromosome 17, clathrin, heavy polypeptide (Hc), clathrin, heavy polypeptide-like 2
Species: human
Products:     Clathrin Heavy Chain

Top Publications

  1. Seet L, Hong W. Endofin recruits clathrin to early endosomes via TOM1. J Cell Sci. 2005;118:575-87 pubmed
    ..reveal the biological consequence of endofin-mediated endosomal recruitment of TOM1, we have identified the clathrin heavy chain as a major interacting protein for TOM1...
  2. Huang F, Khvorova A, Marshall W, Sorkin A. Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem. 2004;279:16657-61 pubmed
    ..The knock-downs of clathrin heavy chain and dynamin produced maximal inhibitory effects on the internalization of both receptors...
  3. Choudhury R, Diao A, Zhang F, Eisenberg E, Saint Pol A, Williams C, et al. Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. Mol Biol Cell. 2005;16:3467-79 pubmed
    ..OCRL1 interacts directly with clathrin heavy chain and promotes clathrin assembly in vitro...
  4. Teo M, Tan L, Lim L, Manser E. The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. J Biol Chem. 2001;276:18392-8 pubmed
    ..The co-localization of ACK1 in vivo with clathrin and AP-2 indicates that it participates in trafficking, underlying an ability to increase receptor-mediated transferrin uptake. ..
  5. Enari M, Ohmori K, Kitabayashi I, Taya Y. Requirement of clathrin heavy chain for p53-mediated transcription. Genes Dev. 2006;20:1087-99 pubmed
    ..Here, we report that clathrin heavy chain (CHC) binds to p53 and contributes to p53-mediated transcription...
  6. Booth D, Hood F, Prior I, Royle S. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 2011;30:906-19 pubmed publisher
    ..Our results suggest that the TACC3/ch-TOG/clathrin complex is an inter-MT bridge that stabilises K-fibres by physical crosslinking and by reducing rates of MT catastrophe. ..
  7. Yamakami M, Yoshimori T, Yokosawa H. Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin. J Biol Chem. 2003;278:52865-72 pubmed
    ..In addition, Tom1 was found to be capable of binding to clathrin heavy chain through a typical clathrin-binding motif...
  8. Royle S, Bright N, Lagnado L. Clathrin is required for the function of the mitotic spindle. Nature. 2005;434:1152-7 pubmed
    ..Clathrin bound to the spindle directly by the amino-terminal domain of clathrin heavy chain. Depletion of clathrin heavy chain using RNA interference prolonged mitosis; kinetochore fibres were ..
  9. Esk C, Chen C, Johannes L, Brodsky F. The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step. J Cell Biol. 2010;188:131-44 pubmed publisher
    b>Clathrin heavy chain 22 (CHC22) is an isoform of the well-characterized CHC17 clathrin heavy chain, a coat component of vesicles that mediate endocytosis and organelle biogenesis...

More Information


  1. Lundmark R, Carlsson S. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. J Biol Chem. 2003;278:46772-81 pubmed
    ..Overexpression in both K562 and HeLa cells of truncated forms of SNX9 interfered with the uptake of transferrin, consistent with a role of SNX9 in endocytosis. ..
  2. Mao Y, Balkin D, Zoncu R, Erdmann K, Tomasini L, Hu F, et al. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J. 2009;28:1831-42 pubmed publisher
    ..We show that the NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain. OCRL, which in contrast to INPP5B visits late stage endocytic clathrin-coated pits, was earlier shown to ..
  3. Bosch B, Grigorov B, Senserrich J, Clotet B, Darlix J, Muriaux D, et al. A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission. Antiviral Res. 2008;80:185-93 pubmed publisher
  4. Radulescu A, Shields D. Clathrin is required for postmitotic Golgi reassembly. FASEB J. 2012;26:129-36 pubmed publisher
    ..Here we identified a novel step in postmitotic Golgi reassembly that requires the clathrin heavy chain (CHC)...
  5. Towler M, Gleeson P, Hoshino S, Rahkila P, Manalo V, Ohkoshi N, et al. Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol Biol Cell. 2004;15:3181-95 pubmed
    The muscle isoform of clathrin heavy chain, CHC22, has 85% sequence identity to the ubiquitously expressed CHC17, yet its expression pattern and function appear to be distinct from those of well-characterized clathrin-coated vesicles...
  6. Katoh Y, Imakagura H, Futatsumori M, Nakayama K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem Biophys Res Commun. 2006;341:143-9 pubmed
    ..These results indicate that, in conjunction with Tollip, Tom1 family proteins play an important role in recruiting clathrin onto endosomes and suggest that they modulate endosomal functions. ..
  7. Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J. 2006;25:3750-61 pubmed
    ..We conclude that rabs play a dual role in regulation of OCRL1, firstly targeting it to the Golgi apparatus and endosomes, and secondly, directly stimulating the 5-phosphatase activity of OCRL1 after membrane recruitment. ..
  8. Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S, et al. A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 2008;27:1852-62 pubmed publisher
    ..Thus, identification of the Myb-Clafi complex reveals a previously unrecognized function of B-Myb that may contribute to its role in chromosome stability, possibly, tumour suppression. ..
  9. Brett T, Traub L, Fremont D. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure. 2002;10:797-809 pubmed
    ..A mechanism of clathrin assembly regulation is suggested by three different AP-2 engagement modes. ..
  10. Hood F, Royle S. Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis. J Cell Sci. 2009;122:2185-90 pubmed publisher
    ..Two clathrin heavy chains (CHCs) are found in humans: the ubiquitous CHC17, and CHC22, a CHC that is enriched in skeletal muscle...
  11. Ravikumar B, Moreau K, Jahreiss L, Puri C, Rubinsztein D. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol. 2010;12:747-57 pubmed publisher
  12. ter Haar E, Musacchio A, Harrison S, Kirchhausen T. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 1998;95:563-73 pubmed
    ..We report the crystal structure at 2.6 A resolution of a 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain. The structure comprises the globular "terminal domain" and the linker that joins it to the end ..
  13. Dell Angelica E, Klumperman J, Stoorvogel W, Bonifacino J. Association of the AP-3 adaptor complex with clathrin. Science. 1998;280:431-4 pubmed
    ..clathrin by interaction of the appendage domain of its beta3 subunit with the amino-terminal domain of the clathrin heavy chain. The beta3 appendage domain contained a conserved consensus motif for clathrin binding...
  14. Gumpert A, Varco J, Baker S, Piehl M, Falk M. Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery. FEBS Lett. 2008;582:2887-92 pubmed publisher
    ..To our knowledge, we are first to report that the endocytic clathrin machinery can internalize double-membrane vesicles into cells. ..
  15. Vassilopoulos S, Esk C, Hoshino S, Funke B, Chen C, Plocik A, et al. A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism. Science. 2009;324:1192-6 pubmed publisher
    ..Thus, CHC22-dependent membrane trafficking constitutes a species-restricted pathway in human muscle and fat with potential implications for type 2 diabetes. ..
  16. Shimizu H, Nagamori I, Yabuta N, Nojima H. GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression. J Cell Sci. 2009;122:3145-52 pubmed publisher
    Cyclin G-associated kinase (GAK) is an association partner of clathrin heavy chain (CHC) and is essential for clathrin-mediated membrane trafficking...
  17. Lin C, Hu C, Shih H. Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. J Cell Biol. 2010;189:1097-105 pubmed publisher
    ..In this study, we identified clathrin heavy chain (CHC) as an adaptor protein to recruit S558-phosphorylated TACC3 onto the spindle during mitosis for MT ..
  18. Kedra D, Peyrard M, Fransson I, Collins J, Dunham I, Roe B, et al. Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11. Hum Mol Genet. 1996;5:625-31 pubmed
    We report cloning and characterization of the second human clathrin heavy chain polypeptide gene (CLH-22) localized to chromosome 22q11. Hence H. sapiens is the first species for which two clathrin heavy chain genes have been reported...
  19. Hinrichsen L, Harborth J, Andrees L, Weber K, Ungewickell E. Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. J Biol Chem. 2003;278:45160-70 pubmed
    ..the contribution of individual endocytic proteins to the assembly of clathrin coated pits, we depleted the clathrin heavy chain and the alpha-adaptin subunit of AP-2 in HeLa-cells using RNA interference...
  20. Chen C, Brodsky F. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J Biol Chem. 2005;280:6109-17 pubmed
    ..We demonstrate Hip1R binding preference for light chains associated with clathrin heavy chain and show that Hip1R stimulation of clathrin assembly in vitro is blocked by mutations in the conserved ..
  21. Mills I, Praefcke G, Vallis Y, Peter B, Olesen L, Gallop J, et al. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J Cell Biol. 2003;160:213-22 pubmed
  22. Raiborg C, Bache K, Mehlum A, Stang E, Stenmark H. Hrs recruits clathrin to early endosomes. EMBO J. 2001;20:5008-21 pubmed
    ..contains a functional clathrin box motif that interacts directly with the terminal beta-propeller domain of clathrin heavy chain. A massive recruitment of clathrin to early endosomes was observed in cells transfected with Hrs, but not ..
  23. Drake M, Downs M, Traub L. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. J Biol Chem. 2000;275:6479-89 pubmed
    ..amphiphysin, and beta-arrestin, facilitates the association of epsin 1 with the terminal domain of the clathrin heavy chain. Unexpectedly, inhibiting the binding of AP-2 to the GST-epsin DPW fusion protein by progressively deleting ..
  24. Yeow Fong L, Lim L, Manser E. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. FEBS Lett. 2005;579:5040-8 pubmed
  25. Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell E. Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Mol Biol Cell. 2002;13:4060-73 pubmed
    ..Our results suggest that Clint might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors. ..
  26. Popoff V, Mardones G, Tenza D, Rojas R, Lamaze C, Bonifacino J, et al. The retromer complex and clathrin define an early endosomal retrograde exit site. J Cell Sci. 2007;120:2022-31 pubmed
    ..Our findings thus establish a role for the retromer complex in retrograde transport of the B-subunit of Shiga toxin, and strongly suggest that clathrin and retromer function in consecutive retrograde sorting steps on early endosomes. ..
  27. He G, Gupta S, Yi M, Michaely P, Hobbs H, Cohen J. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. J Biol Chem. 2002;277:44044-9 pubmed
    ..clathrin was mapped to a canonical clathrin box sequence (LLDLE) in ARH and to the N-terminal domain of the clathrin heavy chain. A highly conserved 20-amino acid sequence in the C-terminal region of ARH bound the beta(2)-adaptin ..
  28. Kalthoff C, Alves J, Urbanke C, Knorr R, Ungewickell E. Unusual structural organization of the endocytic proteins AP180 and epsin 1. J Biol Chem. 2002;277:8209-16 pubmed
  29. Rosenthal J, Chen H, Slepnev V, Pellegrini L, Salcini A, Di Fiore P, et al. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. J Biol Chem. 1999;274:33959-65 pubmed
    ..The epsins define a new protein family implicated in membrane dynamics at the cell surface. ..
  30. Motley A, Bright N, Seaman M, Robinson M. Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol. 2003;162:909-18 pubmed
    We have used RNA interference to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cells...
  31. Akpo E, Sbarigia U, Wan G, Kleintjens J. Determinant Factors of the Direct Medical Costs Associated with Genotype 1 Hepatitis C Infection in Treatment-Experienced Patients. Drugs R D. 2015;15:335-49 pubmed publisher
    ..that predict MRU and related non-drug costs in treatment-experienced patients with chronic hepatitis C (CHC) treated with simeprevir (SMV) or telapravir (TVR) in combination with pegylated interferon and ribavirin (PegIFN/R)..
  32. Sciarra A, Di Tommaso L, Nakano M, Destro A, Torzilli G, Donadon M, et al. Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications. J Hepatol. 2016;64:87-93 pubmed publisher
    ..the vascular profile, ductular reaction/stromal invasion and overexpression of five biomarkers (GPC3, HSP70, GS, CHC, and EZH2), in a series of 100 resected nodules (13 LGDN, 16 HGDN, 42 eHCC and 29 small pHCC)...
  33. Guillem R, Drijfhout F, Martin S. Species-Specific Cuticular Hydrocarbon Stability within European Myrmica Ants. J Chem Ecol. 2016;42:1052-1062 pubmed
    ..We tested this hypothesis by comparing the CHC profiles of workers of twelve species of Myrmica ants from four countries across Europe, from Iberia to the Balkans ..
  34. Hatch B, Marino M, Killerby M, Angier H, Hoopes M, Bailey S, et al. Medicaid's Impact on Chronic Disease Biomarkers: A Cohort Study of Community Health Center Patients. J Gen Intern Med. 2017;32:940-947 pubmed publisher
    ..To assess changes in biomarkers of chronic disease among community health center (CHC) patients who gained Medicaid coverage with the Oregon Medicaid expansion (2008-2011). Prospective cohort...
  35. Peng M, Yin N, Zhang W. Endocytosis of FcalphaR is clathrin and dynamin dependent, but its cytoplasmic domain is not required. Cell Res. 2010;20:223-37 pubmed publisher
    ..of different endocytic pathways, overexpression of dominant-negative mutants of Eps15 and knockdown of clathrin heavy chain (CHC) via RNA interference, we demonstrated that endocytosis of FcalphaR was through a clathrin-mediated ..
  36. dos Santos C, Ferreira Caliman M, Nascimento F. An alien in the group: eusocial male bees sharing nonspecific reproductive aggregations. J Insect Sci. 2015;15: pubmed publisher
    ..We also compared the CHC profiles of males of Neotropical stingless bee species (Plebeia sp. Schwarz, Trigona spinipes (F...
  37. Kwon J, Bae S, Lee Y, Lee J, Kim Y, Hwang J, et al. The virological response in Koreans infected with HCV genotype 1 did not differ between groups treated with a full dose or reduced dose (≥80 % full dose) of peginterferon alfa-2a: a prospective randomized multicenter trial. Hepatol Int. 2013;7:1000-9 pubmed publisher
    A high rate of sustained viral response (SVR) in Koreans with chronic hepatitis C (CHC) is related to a favorable IL28B genotype...
  38. Shorter J, Dembeck L, Everett L, Morozova T, Arya G, Turlapati L, et al. Obp56h Modulates Mating Behavior in Drosophila melanogaster. G3 (Bethesda). 2016;6:3335-3342 pubmed publisher
    ..results from inhibition of Obp56h expression is accompanied by significant alterations in cuticular hydrocarbon (CHC) composition, including reduction in 5-tricosene (5-T), an inhibitory sex pheromone produced by males that ..
  39. Latomanski E, Newton P, Khoo C, Newton H. The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii. PLoS Pathog. 2016;12:e1006101 pubmed publisher
  40. Megahed A, Salem N, Fathy A, Barakat T, Alsayed M, Mabood S, et al. Pegylated interferon ?/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection. World J Pediatr. 2017;13:346-352 pubmed publisher
    The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children, especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ..
  41. Zheng Y, Zhou P, Zhou R, Fan X. The benefit of statins in chronic hepatitis C patients: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29:759-766 pubmed publisher
    ..The potential benefit of statins using in chronic hepatitis C (CHC) patients is not well described...
  42. de Souza M, Vaisberg V, Abreu R, Ferreira A, daSilvaFerreira C, Nasser P, et al. UGT1A1*28 relationship with abnormal total bilirubin levels in chronic hepatitis C patients: Outcomes from a case-control study. Medicine (Baltimore). 2017;96:e6306 pubmed publisher
    ..Our aim was to assess UGT1A1 genotypes' frequency in chronic hepatitis C (CHC) patients and correlate with total bilirubin (TB). This is a case-control study in a large tertiary medical center...
  43. Wang J, Wang H, Wang C, Zhang L, Wang T, Zheng L. A novel process for separation of hazardous poly(vinyl chloride) from mixed plastic wastes by froth flotation. Waste Manag. 2017;69:59-65 pubmed publisher
    A novel method, calcium hypochlorite (CHC) treatment, was proposed for separation of hazardous poly(vinyl chloride) (PVC) plastic from mixed plastic wastes (MPWs) by froth flotation...
  44. Nakamura M, Tanaka N, Kitamura N, Komada M. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Genes Cells. 2006;11:593-606 pubmed
    ..We further show that AMSH and AMSH-LP bind to the terminal domain of clathrin heavy chain via a novel clathrin-binding site conserved between these proteins...
  45. Paul S, Das P, Mahanta M, Sreenivas V, Kedia S, Kalra N, et al. Assessment of liver fibrosis in chronic hepatitis: comparison of shear wave elastography and transient elastography. Abdom Radiol (NY). 2017;42:2864-2873 pubmed publisher
    ..SWE) and transient elastography (TE) in the evaluation of liver fibrosis in chronic hepatitis B (CHB) and C (CHC) patients taking liver biopsy as gold standard. Ethics committee approved this prospective cross-sectional study...
  46. Sitruk Ware R. Hormonal contraception and thrombosis. Fertil Steril. 2016;106:1289-1294 pubmed publisher
    ..To improve the safety of CHC, modifying the estrogen dose and type, selecting newer progestins, and alternative routes of delivery were ..
  47. Jimenez Sousa M, Gómez Moreno A, Pineda Tenor D, Medrano L, Sánchez Ruano J, Fernandez Rodriguez A, et al. CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study. Clin Transl Med. 2017;6:26 pubmed publisher
    ..Our data suggest that CXCL9-11 polymorphisms may play a significant role against the progression of CHC and could help prioritize antiviral therapy.
  48. Wurdack M, Polidori C, Keller A, Feldhaar H, Schmitt T. Release from prey preservation behavior via prey switch allowed diversification of cuticular hydrocarbon profiles in digger wasps. Evolution. 2017;71:2562-2571 pubmed publisher
    The cuticle of insects is covered by a layer of hydrocarbons (CHC), whose original function is the protection from desiccation and pathogens. However, in most insects CHC profiles are species specific...
  49. Yoh K, Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, et al. Predictors Associated with Increase in Skeletal Muscle Mass after Sustained Virological Response in Chronic Hepatitis C Treated with Direct Acting Antivirals. Nutrients. 2017;9: pubmed publisher
    We aimed to examine changes in skeletal muscle mass in chronic hepatitis C (CHC) patients undergoing interferon (IFN)-free direct acting antivirals (DAAs) therapy who achieved sustained virological response (SVR)...
  50. Popov S, Strack B, Sanchez Merino V, Popova E, Rosin H, Gottlinger H. Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag. J Virol. 2011;85:3792-801 pubmed publisher
    ..Taken together, our results indicate that primate lentiviruses from two different subgroups functionally interact with clathrin during assembly. ..
  51. Mabrouk M, Chejara D, Mulla J, Badhe R, Choonara Y, Kumar P, et al. Design of a novel crosslinked HEC-PAA porous hydrogel composite for dissolution rate and solubility enhancement of efavirenz. Int J Pharm. 2015;490:429-37 pubmed publisher
    The purpose of this research was to synthesize, characterize and evaluate a Crosslinked Hydrogel Composite (CHC) as a new carrier for improving the solubility of the anti-HIV drug, efavirenz...
  52. Rosa J, Barbacid M. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Oncogene. 1997;15:1-6 pubmed
    ..We report here the isolation of a clone that encodes the last 654 amino acid residues of the clathrin heavy chain. This interaction involves amino acid residues 1315-1557 of the clathrin heavy chain and the carboxy, but ..
  53. Bernhardt V, Pogoda W, Verhoff M, Toennes S, Amendt J. Estimating the age of the adult stages of the blow flies Lucilia sericata and Calliphora vicina (Diptera: Calliphoridae) by means of the cuticular hydrocarbon n-pentacosane. Sci Justice. 2017;57:361-365 pubmed publisher
    ..We investigated the CHC n-pentacosane (nC25) on the legs of the adult blow flies Lucilia sericata and Calliphora vicina with gas ..
  54. Kim C, Bergelson J. Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7. MBio. 2012;3: pubmed publisher
  55. Liu Z, Wang S, Qi W, Wang X, Sun D, Wang H, et al. The relationship between ITPA rs1127354 polymorphisms and efficacy of antiviral treatment in Northeast Chinese CHC patients. Medicine (Baltimore). 2017;96:e7554 pubmed publisher
    ..IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the SVR to PEG-IFN plus ribavirin combination therapy in Chinese HCV-infected patients. ..
  56. Meyer Zu Hörste M, Ströher E, Berchner Pfannschmidt U, Schmitz Spanke S, Pink M, Gothert J, et al. A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit. J Clin Endocrinol Metab. 2011;96:E1727-36 pubmed publisher
    ..Clathrin heavy-chain (CHC) expression was inhibited with small interfering RNA technology.
  57. Hussain N, Yamabhai M, Ramjaun A, Guy A, Baranes D, O Bryan J, et al. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. J Biol Chem. 1999;274:15671-7 pubmed
    ..These data suggest that the long and short forms of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. ..
  58. Turner C, Brown M, Perrotta J, Riedy M, Nikolopoulos S, McDonald A, et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol. 1999;145:851-63 pubmed
    ..These data implicate paxillin as a mediator of p21 GTPase-regulated actin cytoskeletal reorganization through the recruitment to nascent focal adhesion structures of an active PAK/PIX complex potentially via interactions with p95PKL. ..
  59. Ohmori K, Endo Y, Yoshida Y, Ohata H, Taya Y, Enari M. Monomeric but not trimeric clathrin heavy chain regulates p53-mediated transcription. Oncogene. 2008;27:2215-27 pubmed
    ..Recently, we showed that clathrin heavy chain (CHC), which was originally identified as a cytosolic protein regulating endocytosis, is present in nuclei ..
  60. Dammermann W, Polywka S, Dettmann I, Mindorf S, Komorowski L, Wehmeyer M, et al. Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort. Med Microbiol Immunol. 2017;206:379-382 pubmed publisher
    ..against inosine-5'-monophosphate-dehydrogenase-2 (IMPDH2; "rods and rings" pattern) develop in chronic hepatitis C (CHC) patients under treatment with peg-interferon (IFN) and ribavirin (RBV), an inhibitor of IMPDH2...
  61. Skånland S, Walchli S, Brech A, Sandvig K. SNX4 in complex with clathrin and dynein: implications for endosome movement. PLoS ONE. 2009;4:e5935 pubmed publisher
    ..We discuss the possibility of clathrin serving as a regulator of SNX4-dependent transport. Upon clathrin release, dynein may bind SNX4 and mediate retrograde movement. ..
  62. Ishino Y, Yetman M, Sossi S, Steinecke A, Hayano Y, Taniguchi H. Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells. J Neurosci. 2017;37:9901-9916 pubmed publisher
    ..The chandelier cell (ChC) is a highly stereotyped IN type that innervates axon initial segments of PNs and thus serves as a good model with ..
  63. Laporte S, Oakley R, Zhang J, Holt J, Ferguson S, Caron M, et al. The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A. 1999;96:3712-7 pubmed
    ..AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptors such as those for epidermal growth factor and transferrin...
  64. Wang S, Aldridge M, Canavan M, Cherlin E, Bradley E. Continuous Home Care Reduces Hospice Disenrollment and Hospitalization After Hospice Enrollment. J Pain Symptom Manage. 2016;52:813-821 pubmed publisher
    Among the four levels of hospice care, continuous home care (CHC) is the most expensive care, and infrequently provided in practice...
  65. Polidori C, Giordani I, Wurdack M, Tormos J, Asís J, Schmitt T. Post-mating shift towards longer-chain cuticular hydrocarbons drastically reduces female attractiveness to males in a digger wasp. J Insect Physiol. 2017;100:119-127 pubmed publisher
    ..In several bee species, the cuticular hydrocarbon (CHC) profile exhibited by virgin females elicits male copulation attempts...
  66. Dodge G, Kovalszky I, McBride O, Yi H, Chu M, Saitta B, et al. Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. Genomics. 1991;11:174-8 pubmed
    ..5 kb, which is consistent with the predicted 180 kDa molecular weight of the clathrin heavy chain. Southern analysis of human/rodent somatic cell hybrids localized the human clathrin heavy chain gene (CLTC)..
  67. Gautier J, Lomakina M, Bouslama Oueghlani L, Derivery E, Beilinson H, Faigle W, et al. Clathrin is required for Scar/Wave-mediated lamellipodium formation. J Cell Sci. 2011;124:3414-27 pubmed publisher
    ..This screen identified Clathrin heavy chain (CHC) as a protein that binds to the SWC and whose depletion affects lamellipodium formation...
  68. Angier H, Hoopes M, Marino M, Huguet N, Jacobs E, Heintzman J, et al. Uninsured Primary Care Visit Disparities Under the Affordable Care Act. Ann Fam Med. 2017;15:434-442 pubmed publisher
    ..Thus, we aimed to assess changes in insurance coverage at community health center (CHC) visits after the Patient Protection and Affordable Care Act (ACA) Medicaid expansion by race and ethnicity...
  69. Wu X, Zhao X, Puertollano R, Bonifacino J, Eisenberg E, Greene L. Adaptor and clathrin exchange at the plasma membrane and trans-Golgi network. Mol Biol Cell. 2003;14:516-28 pubmed
    ..We conclude that clathrin-coated pits are dynamic structures with rapid exchange of both clathrin and adaptors and that adaptors are able to exchange independently of clathrin when clathrin exchange is blocked. ..
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    ..The association of Trk receptors with components of cytoplasmic dynein suggests that transport of neurotrophins during vesicular trafficking may occur through a direct interaction of the Trk receptor with the dynein motor machinery. ..
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    ..Together, these findings indicate that Eps15 plays an important role in clathrin-coated vesicle formation not only at the plasma membrane but also at the TGN during the secretory process. ..
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    ..DM) and the risk of hepatitis C virus (HCV)-related liver cirrhosis in Chinese patients with chronic hepatitis C (CHC)...
  73. Legendre Guillemin V, Metzler M, Charbonneau M, Gan L, Chopra V, Philie J, et al. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. J Biol Chem. 2002;277:19897-904 pubmed
    ..and AP2 consensus-binding sites that display high affinity binding to the terminal domain of the clathrin heavy chain and the ear domain of the AP2 alpha subunit, respectively...
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    ..association of interleukin (IL) 10 polymorphisms with sustained virological response (SVR) in chronic hepatitis C (CHC)...
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    ..We conclude that like hKIAA1199, mKiaa1199 is a hyaladherin, leading to HA depolymerization. ..