CKLiK

Summary

Gene Symbol: CKLiK
Description: calcium/calmodulin-dependent protein kinase ID
Alias: CKLiK, CaM-K1, CaMKID, CaM kinase ID, CamKI-like protein kinase, caM kinase I delta, caM-KI delta, caMKI delta, calcium/calmodulin-dependent protein kinase type 1D
Species: human

Top Publications

  1. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  2. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
  3. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
  4. ncbi Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function
    Sandra Verploegen
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 106:1076-83. 2005
  5. pmc RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation
    Steven Haney
    Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, USA
    PLoS ONE 8:e64946. 2013
  6. pmc Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population
    Marco Alberto Gamboa-Meléndez
    Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
    Diabetes 61:3314-21. 2012
  7. doi Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
    Eun Seok Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 88:693-8. 2009
  8. pmc Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study
    Matthias B Schulze
    Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Diabetes Care 32:2116-9. 2009
  9. pmc Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
    Hana Lango Allen
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U K
    Diabetes 59:266-71. 2010
  10. pmc Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    Annemarie M Simonis-Bik
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:293-301. 2010

Scientific Experts

  • Valeriya Lyssenko
  • Xiao Shu
  • Hana Lango Allen
  • Matthias B Schulze
  • Peter Gaines
  • James Meigs
  • S S Hook
  • Harald Staiger
  • H Sakagami
  • Tsuneyuki Oikawa
  • DHARAMBIR SANGHERA
  • Niels Grarup
  • Sonia Caprio
  • Leif Groop
  • Markku Laakso
  • Torben Hansen
  • Eleftheria Zeggini
  • Steven Haney
  • Rajesh Ramakrishnan
  • Marco Alberto Gamboa-Meléndez
  • M Imamura
  • Jie Wen
  • D Schleinitz
  • S Maeda
  • A Kashiwagi
  • Y Nakamura
  • R Kawamori
  • Y Tanaka
  • Dai Zhan Zhou
  • Jianhua Zhao
  • Xianshu Wang
  • Annemarie M Simonis-Bik
  • H Hirose
  • K Kaku
  • Ema C Brito
  • Georgia Salanti
  • X Lin
  • S Omori
  • Trine Welløv Boesgaard
  • Eun Seok Kang
  • Laura J Scott
  • Andrew D Morris
  • Nicholas J Wareham
  • Ines Barroso
  • Thomas Illig
  • Mark I McCarthy
  • Timothy M Frayling
  • Michael Boehnke
  • David Altshuler
  • Kristin Ardlie
  • Benjamin F Voight
  • Andrew T Hattersley
  • Harald Grallert
  • Claudia Langenberg
  • Colin N A Palmer
  • Frank B Hu
  • Oluf Pedersen
  • Felicity Payne
  • Johanna Kuusisto
  • Kristian Hveem
  • Robert B White
  • Anna Bergamaschi
  • Akifumi Kamata
  • Hiroshi Tokumitsu
  • Sandra Verploegen
  • Toshiyuki Yamada
  • Yumi Ishikawa
  • Kurt Eng
  • Juan Zhao
  • Eric Tien
  • Shiwani Tiwari
  • Lin T Guey
  • Hortensia Moreno-Macias
  • Israel Lerman-Garber
  • María Teresa Tusié-Luna
  • Alicia Huerta-Chagoya
  • Andrew P Rice
  • Luz Elizabeth Guillén-Pineda
  • Maria Luisa Ordonez-Sanchez
  • Gustavo Pérez-Ortiz
  • Paola Vázquez-Cárdenas
  • Shweta Choudhry
  • Rosario Rodriguez-Guillén
  • Laura Del Bosque-Plata
  • María Teresa Guerra-García
  • Fernando Escobedo-Aguirre
  • Maribel Rodriguez-Torres
  • Samuel Canizales-Quinteros
  • Laura Riba
  • Adalberto Parra

Detail Information

Publications36

  1. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  2. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  3. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  4. ncbi Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function
    Sandra Verploegen
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 106:1076-83. 2005
    ..Recently, we identified a novel Ca2+/calmodulin-dependent kinase I-like kinase, CKLiK, which exhibits restricted mRNA expression to human granulocytes...
  5. pmc RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation
    Steven Haney
    Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, USA
    PLoS ONE 8:e64946. 2013
    ....
  6. pmc Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population
    Marco Alberto Gamboa-Meléndez
    Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
    Diabetes 61:3314-21. 2012
    ..Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects...
  7. doi Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
    Eun Seok Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 88:693-8. 2009
    ..Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea...
  8. pmc Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study
    Matthias B Schulze
    Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Diabetes Care 32:2116-9. 2009
    ..We investigated whether metabolic biomarkers and single nucleotide polymorphisms (SNPs) improve diabetes prediction beyond age, anthropometry, and lifestyle risk factors...
  9. pmc Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
    Hana Lango Allen
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U K
    Diabetes 59:266-71. 2010
    ..We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis...
  10. pmc Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    Annemarie M Simonis-Bik
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:293-301. 2010
    ..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function...
  11. pmc Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
    Trine Welløv Boesgaard
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 4:e7236. 2009
    ....
  12. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
  13. pmc Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
    Jie Wen
    Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
    PLoS ONE 5:e9153. 2010
    ..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort...
  14. pmc Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Hum Mol Genet 19:2886-97. 2010
    ..Upon further validation, these SNPs together with other genetic and environmental factors may improve breast cancer risk assessment in these populations...
  15. pmc Identification of new genetic risk variants for type 2 diabetes
    Xiao Ou Shu
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS Genet 6:e1001127. 2010
    ..Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS...
  16. doi Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese
    Dai Zhan Zhou
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, PR China
    J Hum Genet 55:810-5. 2010
    ..15(1.10-1.21); P=1.93 × 10(-8)). This large population-based study and meta-analysis further confirmed the modest effects of the JAZF1, TSPAN8/LGR5 and HHEX-IDE loci on type 2 diabetes in Chinese and other East Asians...
  17. pmc Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway
    Rajesh Ramakrishnan
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Physiol 227:609-17. 2012
    ....
  18. doi Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population
    M Imamura
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetologia 54:3071-7. 2011
    ..The aim of the present study was to ascertain the role of these four variants in conferring susceptibility to type 2 diabetes in the Japanese population...
  19. doi Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits
    D Schleinitz
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig 04109, Germany
    Horm Metab Res 42:14-22. 2010
    ..This is compatible with the modest effect size of these "second sweep" variants, which will require large-scale association studies on quantitative traits to clarify their role in the pathophysiology of T2D...
  20. pmc Underlying genetic models of inheritance in established type 2 diabetes associations
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Epidemiol 170:537-45. 2009
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments...
  21. ncbi Ca(2+)/CaM-dependent kinases: from activation to function
    S S Hook
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Annu Rev Pharmacol Toxicol 41:471-505. 2001
    ..Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms...
  22. ncbi Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells
    Yumi Ishikawa
    Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 550:57-63. 2003
    ..This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells...
  23. ncbi Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Exp Cell Res 294:39-50. 2004
    ..Because the gene exhibited about 90% homology with the human calcium-calmodulin-dependent kinase I-like kinase (CKLiK) gene, it was identified as a mouse homologue of human CKLiK...
  24. ncbi Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Eur J Neurosci 22:2697-707. 2005
    ..Our present study provides the first evidence for the possible involvement of CaMKIdelta in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx...
  25. ncbi Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
    Akifumi Kamata
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
    Neurosci Res 57:86-97. 2007
    ....
  26. doi Genome-wide discovery of Pax7 target genes during development
    Robert B White
    School of Exercise Biomedical and Health Science, Edith Cowan University, Joondalup, Western Australia, Australia
    Physiol Genomics 33:41-9. 2008
    ..This analysis gives us greater insight into the direct functional role played by Pax7 during embryonic development...
  27. pmc A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils
    Peter Gaines
    Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Exp Hematol 36:832-44. 2008
    ..we have investigated the role of two members of the calcium/calmodulin-dependent protein kinase (CaMK) signaling cascade, CaMK I-like kinase (CKLiK) and CaMKKalpha, in regulating neutrophil differentiation and functional activation.
  28. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  29. pmc Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3019. 2008
    ..e., obesity, impaired insulin secretion, and insulin resistance...
  30. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  31. doi Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Hum Genet 54:162-8. 2009
    ..on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians...
  32. pmc Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
    Ema C Brito
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetes 58:1411-8. 2009
    ....
  33. pmc CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Mol Oncol 2:327-39. 2008
    ..Our findings identify CAMK1D as a novel amplified oncogene linked to EMT in breast cancer, and as a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors...
  34. doi Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals
    S Omori
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa 230 0045, Japan
    Diabetologia 52:1554-60. 2009
    ..To examine further the roles of these new loci, we performed a replication study for the association of these single-nucleotide polymorphism (SNP) loci with the disease in three independent Japanese populations...
  35. ncbi Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase
    S Verploegen
    Department of Pulmonary Diseases, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
    Blood 96:3215-23. 2000
    ..This has been termed CaMKI-like kinase (CKLiK)...

Research Grants38

  1. Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
    Sonia Caprio; Fiscal Year: 2010
    ..Our long term goal is to generate information on both the genetics as well as the pathophysiology of Type 2 Diabetes in Youth, which ultimately might guide us towards better preventive and treatment avenues. ..
  2. Cohort Study of Cancer inhibitory Factors in Men
    Xiao Ou Shu; Fiscal Year: 2006
    ....
  3. Cohort Study of Cancer-Inhibitory Dietary Factors in Men
    Xiao Ou Shu; Fiscal Year: 2007
    ..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
  4. Breast Cancer Survival: Lifestyle and Genetic Determinants
    Xiao Ou Shu; Fiscal Year: 2009
    ..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
  5. Vanderbilt-Shanghai Chronic Disease Research Training Program
    Xiao Ou Shu; Fiscal Year: 2009
    ..This program will have significant impact on chronic disease research and prevention in China, and possibly extend to other developing countries. ..
  6. Breast Cancer Survival: Lifestyle and Genetic Determinants
    Xiao Ou Shu; Fiscal Year: 2010
    ..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
  7. Soyfood, gene polymorphisms and endometrial cancer risk
    Xiao Ou Shu; Fiscal Year: 2005
    ..Consumption level of soyfood is high and hysterectomy rates are extremely low among Chinese women, providing a unique opportunity to test the hypotheses posed in the application that are difficult to be evaluated in the U.S. population. ..
  8. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    ..The relatively large sample size will provide sufficient statistical power to address the hypotheses being investigated. ..
  9. Cohort Study of Cancer-Inhibitory Dietary Factors in Men
    Xiao Ou Shu; Fiscal Year: 2010
    ..The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men. ..
  10. Soyfood, gene polymorphisms and endometrial cancer risk
    Xiao Ou Shu; Fiscal Year: 2010
    ..abstract_text> ..
  11. Soy Food and Coronary Heart Disease in Women
    Xiao Ou Shu; Fiscal Year: 2007
    ....
  12. Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian
    Dharambir K Sanghera; Fiscal Year: 2010
    ..Identifying the susceptibility loci in a population with high diabetic/cardiovascular risk may be important beyond Indians and will increase our understanding of the disease in other groups. ..
  13. Common Genetic Variation and Diabetes Traits in Framingham
    James B Meigs; Fiscal Year: 2010
    ..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..
  14. Common Genetic Variation and Diabetes Traits in Framingham
    James Meigs; Fiscal Year: 2009
    ..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..
  15. Role of Lamin B Receptor in Neutrophil Maturation and Functional Activation
    Peter Gaines; Fiscal Year: 2007
    ..The results may also offer important insight into the pathogenesis of potentially fatal hematologic disorders. ..
  16. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  17. Epidemiology of Precursors to Type 2 Diabetes
    James Meigs; Fiscal Year: 2007
    ..Expanded knowledge of precursors of type 2 diabetes is critical to identify novel approaches for prevention and control of the widening diabetes epidemic. ..