Genomes and Genes
Gene Symbol: CKLFSF8
Description: CKLF like MARVEL transmembrane domain containing 8
Alias: CKLFSF8, CKLFSF8-V2, CKLF-like MARVEL transmembrane domain-containing protein 8, chemokine-like factor superfamily member 8
- Jiang Y, Zhang H. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. Genet Epidemiol. 2011;35:125-32 pubmed publisher..Our finding underscores the importance of accommodating and controlling for covariate effects in discovering genetic variants associated with complex disorders. ..
- Li D, Jin C, Yin C, Zhang Y, Pang B, Tian L, et al. An alternative splice form of CMTM8 induces apoptosis. Int J Biochem Cell Biol. 2007;39:2107-19 pubmed..CMTM8-v2 did not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXXPhi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization. ..
- Huang Y, Du Y. [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006;22:466-8 pubmedTo investigate the effect of chemokine-like factor superfamily 8 (CKLFSF8) on proliferation and epidermal growth factor receptor (EGFR) expression of tumor cells. Expression of CKLFSF8 mRNA in BGC823 and K562 cells was assayed by RT-PCR...
- Gao D, Hu H, Wang Y, Yu W, Zhou J, Wang X, et al. CMTM8 inhibits the carcinogenesis and progression of bladder cancer. Oncol Rep. 2015;34:2853-63 pubmed..In conclusion, overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer. ..
- Ferreira M, O Donovan M, Meng Y, Jones I, Ruderfer D, Jones L, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40:1056-8 pubmed publisher..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. ..
- Jin C, Ding P, Wang Y, Ma D. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. FEBS Lett. 2005;579:6375-82 pubmedIt is known that chemokine-like factor superfamily 8 (CKLFSF8), a member of the CKLF superfamily, has four putative transmembrane regions and a MARVEL domain...
- Shaffer J, Polk D, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. G3 (Bethesda). 2014;4:307-14 pubmed publisher..Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies. ..