Gene Symbol: CKLFSF8
Description: CKLF like MARVEL transmembrane domain containing 8
Alias: CKLFSF8, CKLFSF8-V2, CKLF-like MARVEL transmembrane domain-containing protein 8, chemokine-like factor superfamily member 8
Species: human
Products:     CKLFSF8

Top Publications

  1. Do C, Lang C, Lin J, Darbary H, Krupska I, Gaba A, et al. Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation. Am J Hum Genet. 2016;98:934-955 pubmed publisher
  2. Lu J, Wu Q, Zhou Y, Zhang K, Pang B, Li L, et al. Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review). Asian Pac J Cancer Prev. 2016;17:2741-4 pubmed
    ..CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system. ..
  3. Jin C, Wang Y, Han W, Zhang Y, He Q, Li D, et al. CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway. J Cell Physiol. 2007;211:112-20 pubmed
    ..These data implicate CMTM8 as a negative regulator of EGF-induced signaling, with potential use as a novel therapeutic gene for EGFR-targeted anticancer gene therapy. ..
  4. Both J, Krijgsman O, Bras J, Schaap G, Baas F, Ylstra B, et al. Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma. PLoS ONE. 2014;9:e115835 pubmed publisher
    ..Further studies are needed to determine whether these proteins also exert the latter functions in osteosarcoma tumorigenesis. ..
  5. Lingappa J, Petrovski S, Kahle E, Fellay J, SHIANNA K, McElrath M, et al. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. PLoS ONE. 2011;6:e28632 pubmed publisher
    ..Alternative strategies, such as large-scale sequencing to identify low frequency variation, should be considered for identifying novel host genetic predictors of HIV-1 acquisition. ..
  6. Zhang S, Pei X, Hu H, Zhang W, Mo X, Song Q, et al. Functional characterization of the tumor suppressor CMTM8 and its association with prognosis in bladder cancer. Tumour Biol. 2016;37:6217-25 pubmed publisher
    ..Altogether, our data suggested that CMTM8 is an important tumor suppressor gene in human bladder cancer and qualified as a useful prognostic indicator for patients with bladder cancer. ..
  7. Zhang W, Qi H, Mo X, Sun Q, Li T, Song Q, et al. CMTM8 is Frequently Downregulated in Multiple Solid Tumors. Appl Immunohistochem Mol Morphol. 2017;25:122-128 pubmed publisher
    ..Our findings strongly supported the potential role of CMTM8 as a novel tumor suppressor and may shape further functional studies on this gene. ..
  8. Zhang W, Mendoza M, Pei X, Ilter D, Mahoney S, Zhang Y, et al. Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem. 2012;287:11850-8 pubmed publisher
    ..Down-regulation of CMTM8 also promoted an EMT-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation. ..
  9. Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
    ..CKLFSF1 has a CC motif and higher sequence similarity with chemokines than with any of the other CKLFSFs. CKLFSF8 shares 39.3% amino acid identity with TM4SF11...

More Information


  1. Jiang Y, Zhang H. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. Genet Epidemiol. 2011;35:125-32 pubmed publisher
    ..Our finding underscores the importance of accommodating and controlling for covariate effects in discovering genetic variants associated with complex disorders. ..
  2. Li D, Jin C, Yin C, Zhang Y, Pang B, Tian L, et al. An alternative splice form of CMTM8 induces apoptosis. Int J Biochem Cell Biol. 2007;39:2107-19 pubmed
    ..CMTM8-v2 did not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXXPhi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization. ..
  3. Huang Y, Du Y. [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006;22:466-8 pubmed
    To investigate the effect of chemokine-like factor superfamily 8 (CKLFSF8) on proliferation and epidermal growth factor receptor (EGFR) expression of tumor cells. Expression of CKLFSF8 mRNA in BGC823 and K562 cells was assayed by RT-PCR...
  4. Ollila H, Soronen P, Silander K, Palo O, Kieseppä T, Kaunisto M, et al. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Mol Psychiatry. 2009;14:351-3 pubmed publisher
  5. Gao D, Hu H, Wang Y, Yu W, Zhou J, Wang X, et al. CMTM8 inhibits the carcinogenesis and progression of bladder cancer. Oncol Rep. 2015;34:2853-63 pubmed
    ..In conclusion, overexpression of CMTM8 in bladder cancer results in reduced malignant cell growth, migration and invasion, which could make it a potential therapeutic target in the treatment of bladder cancer. ..
  6. Ferreira M, O Donovan M, Meng Y, Jones I, Ruderfer D, Jones L, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40:1056-8 pubmed publisher
    ..0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. ..
  7. Jin C, Ding P, Wang Y, Ma D. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. FEBS Lett. 2005;579:6375-82 pubmed
    It is known that chemokine-like factor superfamily 8 (CKLFSF8), a member of the CKLF superfamily, has four putative transmembrane regions and a MARVEL domain...
  8. Shaffer J, Polk D, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. G3 (Bethesda). 2014;4:307-14 pubmed publisher
    ..Though small, efforts such this are needed in order to nominate novel genes and generate new hypotheses for exploration and testing in future studies. ..