Gene Symbol: CKLFSF2
Description: CKLF like MARVEL transmembrane domain containing 2
Alias: CKLFSF2, CKLF-like MARVEL transmembrane domain-containing protein 2, chemokine-like factor superfamily 2, chemokine-like factor superfamily member 2
Species: human
Products:     CKLFSF2

Top Publications

  1. Delic S, Thuy A, Schulze M, Proescholdt M, Dietrich P, Bosserhoff A, et al. Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets. Genes Chromosomes Cancer. 2015;54:433-43 pubmed publisher
    ..Using a human phosphokinase protein expression profiling assay, we can provide first insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation. ..
  2. Choi J, Kim Y, Ahn J, Kim M, Bae W, Han S, et al. Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer. Exp Mol Med. 2018;50:6 pubmed publisher
    ..2 × 10-3). In conclusion, DGCs have distinct profiles of somatic mutations and DNA copy numbers according to the status of lymph node metastasis, and this might be helpful in delineating the pathobiology of DGC. ..
  3. Kumar S, Kang H, Park E, Park H, Lee K. The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis. Biochim Biophys Acta Gene Regul Mech. 2018;1861:1063-1075 pubmed publisher
    ..In the course of evolution, CKLFSF2 has evolved as two isoforms, namely CKLFSF2A and CKLFSF2B, in mice...
  4. van Doorn R, Slieker R, Boonk S, Zoutman W, Goeman J, Bagot M, et al. Epigenomic Analysis of Sézary Syndrome Defines Patterns of Aberrant DNA Methylation and Identifies Diagnostic Markers. J Invest Dermatol. 2016;136:1876-1884 pubmed publisher
    ..This study shows that Sz is characterized by widespread yet distinct DNA methylation alterations, which can be used clinically as epigenetic diagnostic markers. ..
  5. Mays A, Feng X, Browne J, Sullivan C. Chemokine and Chemokine Receptor Profiles in Metastatic Salivary Adenoid Cystic Carcinoma. Anticancer Res. 2016;36:4013-8 pubmed
    ..CCRL1, CCL27, CMTM1, CMTM2 and CKLF may play important roles in the development of tumor metastases in SACC. ..
  6. Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
    ..CKLFSF1 links the CKLFSF family with chemokines, and CKLFSF8 links it with TM4SF. The characteristics of CKLFSF2-7 are intermediate between CKLFSF1 and CKLFSF8...
  7. Xu M, Yang S, Gao Y, Shi S, Ma D. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. Int J Biochem Cell Biol. 2005;37:1296-307 pubmed
    The genes for CKLFSF1 (chemokine-like factor super family member 1) and CKLFSF2 (chemokine-like factor super family member 2) are very closely linked, within 312 bp of each other...
  8. Shi S, Rui M, Han W, Wang Y, Qiu X, Ding P, et al. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. Int J Biochem Cell Biol. 2005;37:1633-40 pubmed
    b>CKLFSF2 is a member of the chemokine-like factor superfamily (CKLFSF), a novel gene family containing CKLF and CKLFSF1-8...
  9. Song H, Shi S, Lu X, Gao F, Yan L, Wang Y, et al. Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. Chin Med J (Engl). 2010;123:2440-5 pubmed
    ..Intracellular CMTM2 can negatively regulate HIV-1 transcription, at least in part, by targeting the AP-1 and CREB pathways. Exploring the mechanisms further may lead to new ways to control HIV-1 replication. ..

More Information


  1. Liu G, Xin Z, Chen L, Tian L, Yuan Y, Song W, et al. Expression and localization of CKLFSF2 in human spermatogenesis. Asian J Androl. 2007;9:189-98 pubmed
    To investigate the expression and subcellular localization of chemokine-like factor superfamily 2 (CKLFSF2) in human testis and its potential role in spermatogenesis. A specific polyclonal antibody against CKLFSF2 was raised...
  2. Fang W, Zheng Y, Wu L, Ke Q, Shen H, Yuan Y, et al. Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients. Asian Pac J Cancer Prev. 2012;13:1917-21 pubmed
    ..Our results show the promise of the microarray technology in identification of potential methylation biomarkers for colorectal cancers. ..