Gene Symbol: CKLFSF1
Description: CKLF like MARVEL transmembrane domain containing 1
Alias: CKLFH, CKLFH1, CKLFSF1, CKLF-like MARVEL transmembrane domain-containing protein 1, chemokine-like factor super family 1, chemokine-like factor superfamily 1, chemokine-like factor superfamily member 1, chemokine-like factor-like protein CKLFH1
Species: human
Products:     CKLFSF1

Top Publications

  1. Fujihara Y, Oji A, Kojima Kita K, Larasati T, Ikawa M. Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018;131: pubmed publisher
    ..We found that co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm fertilizing ability. ..
  2. Mack D, Poulard K, Goddard M, Latournerie V, Snyder J, Grange R, et al. Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs. Mol Ther. 2017;25:839-854 pubmed publisher
    ..These results support the development of gene therapy clinical trials for XLMTM. ..
  3. Lu J, Wu Q, Zhou Y, Zhang K, Pang B, Li L, et al. Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review). Asian Pac J Cancer Prev. 2016;17:2741-4 pubmed
    ..CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system. ..
  4. Mays A, Feng X, Browne J, Sullivan C. Chemokine and Chemokine Receptor Profiles in Metastatic Salivary Adenoid Cystic Carcinoma. Anticancer Res. 2016;36:4013-8 pubmed
    ..CCRL1, CCL27, CMTM1, CMTM2 and CKLF may play important roles in the development of tumor metastases in SACC. ..
  5. Han W, Ding P, Xu M, Wang L, Rui M, Shi S, et al. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003;81:609-17 pubmed
    ..experimental validation identified eight novel genes designated chemokine-like factor superfamily members 1-8 (CKLFSF1-8). CKLFSF1-8 form gene clusters; the sequence identities between CKLF2 and CKLFSF1-8 are from 12.5 to 39.7%...
  6. Wang L, Wu C, Zheng Y, Qiu X, Wang L, Fan H, et al. Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue. Int J Biochem Cell Biol. 2004;36:1492-501 pubmed
    ..with experimental validation, we identified a novel gene designated chemokine-like factor super family member 1 (CKLFSF1). CKLFSF1 maps on chromosome 16q22, and the full-length gene comprises of seven exons and six introns...
  7. Xu M, Yang S, Gao Y, Shi S, Ma D. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. Int J Biochem Cell Biol. 2005;37:1296-307 pubmed
    The genes for CKLFSF1 (chemokine-like factor super family member 1) and CKLFSF2 (chemokine-like factor super family member 2) are very closely linked, within 312 bp of each other...
  8. Wang J, Zhang G, Zhang Y, Luo Y, Song Q, Qiu X, et al. CMTM1_v17 is a novel potential therapeutic target in breast cancer. Oncol Rep. 2014;32:1829-36 pubmed publisher
  9. Delic S, Thuy A, Schulze M, Proescholdt M, Dietrich P, Bosserhoff A, et al. Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets. Genes Chromosomes Cancer. 2015;54:433-43 pubmed publisher
    ..Using a human phosphokinase protein expression profiling assay, we can provide first insights into signalling of these two genes that might be conveyed by growth factor receptor, Src family kinase and WNT activation. ..

More Information


  1. Si J, Zhang P, Tian D, Wang X, Ma Y, Zhang J, et al. CMTM1_v17 is associated with chemotherapy resistance and poor prognosis in non-small cell lung cancer. World J Surg Oncol. 2017;15:34 pubmed publisher
    ..642, P?=?0.002; DFS:HR?=?3.094, P?=?0.002). CMTM1_v17 expression is significantly associated with chemoresistance and poor prognosis of the early stage NSCLC patients who have received NAC. ..