CKI epsilon


Gene Symbol: CKI epsilon
Description: casein kinase 1 epsilon
Alias: CKIe, CKIepsilon, HCKIE, casein kinase I isoform epsilon
Species: human
Products:     CKI epsilon

Top Publications

  1. Carroll J, Liu X, Brodsky A, Li W, Meyer C, Szary A, et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005;122:33-43 pubmed
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells. ..
  2. Knippschild U, Milne D, Campbell L, DeMaggio A, Christenson E, Hoekstra M, et al. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene. 1997;15:1727-36 pubmed
    ..These data suggest that p53 is phosphorylated by CK1delta and CK1epsilon and additionally that there may be a regulatory feedback loop involving p53 and CK1delta. ..
  3. Swiatek W, Tsai I, Klimowski L, Pepler A, Barnette J, Yost H, et al. Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem. 2004;279:13011-7 pubmed
    The Wnt/beta-catenin signaling pathway is important in both development and cancer. Casein kinase Iepsilon (CKIepsilon) is a positive regulator of the canonical Wnt pathway...
  4. Takano A, Uchiyama M, Kajimura N, Mishima K, Inoue Y, Kamei Y, et al. A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders. Neuropsychopharmacology. 2004;29:1901-9 pubmed
    ..Another potential candidate for rhythm disorder susceptibility is casein kinase I epsilon (CKIepsilon), which phosphorylates clock proteins and plays a pivotal role in the circadian clock...
  5. Xu Y, Toh K, Jones C, Shin J, Fu Y, Ptacek L. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. 2007;128:59-70 pubmed
    ..Altering CKIdelta dosage modulates the S662 phenotype demonstrating that CKIdelta can regulate period through PER2 in vivo. Modeling a naturally occurring human variant in mice has yielded novel insights into PER2 regulation. ..
  6. Bryja V, Schulte G, Rawal N, Grahn A, Arenas E. Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci. 2007;120:586-95 pubmed
  7. Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh Hain J, et al. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med. 2012;4:952-63 pubmed publisher
  8. Rivers A, Gietzen K, Vielhaber E, Virshup D. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. J Biol Chem. 1998;273:15980-4 pubmed
    Casein kinase I delta (CKIdelta) and casein kinase I epsilon (CKIepsilon) have been implicated in the response to DNA damage, but the understanding of how these kinases are regulated remains incomplete...
  9. Toh K, Jones C, He Y, Eide E, Hinz W, Virshup D, et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science. 2001;291:1040-3 pubmed
    ..Affected individuals have a serine to glycine mutation within the casein kinase Iepsilon (CKIepsilon) binding region of hPER2, which causes hypophosphorylation by CKIepsilon in vitro...

More Information

Publications102 found, 100 shown here

  1. Kishida M, Hino Si -, Michiue T, Yamamoto H, Kishida S, Fukui A, et al. Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J Biol Chem. 2001;276:33147-55 pubmed
    Although casein kinase Iepsilon (CKIepsilon) has been shown to regulate the Wnt signaling pathway positively, its mode of action is not clear...
  2. Gao Z, Seeling J, Hill V, Yochum A, Virshup D. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A. 2002;99:1182-7 pubmed
    ..Here we show that both CKI delta and CKI epsilon interacted directly with Dvl-1, and that CKI phosphorylated multiple components of the Wnt-regulated beta-..
  3. Amit S, Hatzubai A, Birman Y, Andersen J, Ben Shushan E, Mann M, et al. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 2002;16:1066-76 pubmed
    ..Wnt3A signaling and Dvl overexpression suppress S45 phosphorylation, thereby precluding the initiation of the cascade. Thus, a single, CKI-dependent phosphorylation event serves as a molecular switch for the Wnt pathway. ..
  4. Shirogane T, Jin J, Ang X, Harper J. SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem. 2005;280:26863-72 pubmed
  5. Yang W, Stockwell B. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol. 2008;9:R92 pubmed publisher
    ..These data support the hypothesis that circadian clock genes can control the cell cycle and cell survival signaling, and emphasize a central role of CK1epsilon and PERIOD2 in linking these systems. ..
  6. Kim S, Dunn I, Firestein R, Gupta P, Wardwell L, Repich K, et al. CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS ONE. 2010;5:e8979 pubmed publisher
  7. Foldynova Trantirkova S, Sekyrova P, Tmejová K, Brumovská E, Bernatik O, Blankenfeldt W, et al. Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration. Breast Cancer Res. 2010;12:R30 pubmed publisher
  8. Fish K, Cegielska A, Getman M, Landes G, Virshup D. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. J Biol Chem. 1995;270:14875-83 pubmed
    ..Human CKI epsilon is a novel CKI isoform with properties that overlap those of previously described CKI isoforms.
  9. Cegielska A, Gietzen K, Rivers A, Virshup D. Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis. J Biol Chem. 1998;273:1357-64 pubmed
    Casein kinase I epsilon (CKI epsilon) is a member of the CKI gene family, members of which are involved in the control of SV40 DNA replication, DNA repair, and cell metabolism...
  10. Eide E, Vielhaber E, Hinz W, Virshup D. The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. J Biol Chem. 2002;277:17248-54 pubmed
    The serine/threonine protein kinase casein kinase I epsilon (CKIepsilon) is a key regulator of metazoan circadian rhythm. Genetic and biochemical data suggest that CKIepsilon binds to and phosphorylates the PERIOD proteins...
  11. Nievergelt C, Kripke D, Barrett T, Burg E, Remick R, Sadovnick A, et al. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:234-41 pubmed
    ..However, the trends for ARNTL and PER3 are suggestive of their involvement in bipolar disorder and warrant further study in a larger sample. ..
  12. Luo W, Peterson A, Garcia B, Coombs G, Kofahl B, Heinrich R, et al. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J. 2007;26:1511-21 pubmed
    ..Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling. ..
  13. Shi J, Wittke Thompson J, Badner J, Hattori E, Potash J, Willour V, et al. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1047-55 pubmed publisher
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder. ..
  14. Sakanaka C, Leong P, Xu L, Harrison S, Williams L. Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A. 1999;96:12548-52 pubmed
    ..Using expression cloning to identify novel components of the Wnt pathway, we isolated casein kinase Iepsilon (CKIepsilon)...
  15. Eide E, Woolf M, Kang H, Woolf P, Hurst W, Camacho F, et al. Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol. 2005;25:2795-807 pubmed
    ..b>CKIepsilon (casein kinase Iepsilon) has been postulated to prime PER2 for degradation...
  16. Li V, Ng S, Boersema P, Low T, Karthaus W, Gerlach J, et al. Wnt signaling through inhibition of ?-catenin degradation in an intact Axin1 complex. Cell. 2012;149:1245-56 pubmed publisher
    ..Subsequently, newly synthesized ?-catenin can accumulate in a free cytosolic form and engage nuclear TCF transcription factors. ..
  17. McKenzie J, Riento K, Ridley A. Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett. 2006;580:2388-94 pubmed
    ..We have identified casein kinase I epsilon (CKI epsilon) as a binding partner for the C-terminal cytoplasmic domain of occludin by yeast two-hybrid screening...
  18. Li C, Ao J, Fu J, Lee D, Xu J, Lonard D, et al. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011;30:4350-64 pubmed publisher
    ..Furthermore, we demonstrate that restoration of SPOP expression inhibited SRC-3-mediated oncogenic signaling and tumorigenesis, thus positioning SPOP as a tumor suppressor. ..
  19. Li J, Ma H, Huang Y, Wu L, Li J, Zhao X, et al. No association of a casein kinase 1ε (CK1ε) gene polymorphism with personality traits in healthy Chinese-Han subjects. J Mol Neurosci. 2012;47:437-41 pubmed publisher
    ..However, this difference did not remain statistically significant after Bonferroni correction. Thus, our results did not provide evidence for the association between CK1ε gene and personality traits in healthy Chinese-Han subjects. ..
  20. Varghese R, Liang Y, Guan T, Franck C, Kelly D, Sheng Z. Survival kinase genes present prognostic significance in glioblastoma. Oncotarget. 2016;7:20140-51 pubmed publisher
    ..Importantly, 17 SKGs together presented a novel GBM prognostic signature. SKGs identified herein are associated with recurrence rate and present prognostic significance in GBM, thereby becoming attractive therapeutic targets. ..
  21. Yin H, Laguna K, Li G, Kuret J. Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. Biochemistry. 2006;45:5297-308 pubmed
    ..These data suggest that the acidic domain of dysbindin and its paralogs in humans may function to recruit casein kinase-1 isoforms to protein complexes involved in multiple biological functions. ..
  22. Huisman S, Ahmadi A, Ijzermans J, Verhoef C, van der Horst G, de Bruin R. Disruption of clock gene expression in human colorectal liver metastases. Tumour Biol. 2016;37:13973-13981 pubmed
    ..Our data demonstrate that the core clock is disrupted in CRLM and CRC tissue from the same patient. This disruption may be linked to altered cell-cycle dynamics and carcinogenesis. ..
  23. Pinacho R, Villalmanzo N, Meana J, Ferrer I, Berengueras A, Haro J, et al. Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia. Schizophr Res. 2016;177:88-97 pubmed publisher
    ..roles on cell signaling, neuronal development and synapse functioning for further validation: casein kinase I isoform epsilon (CSNK1E), fatty acid-binding protein 4 (FABP4), neurofilament triplet H protein (NEFH), and retinal ..
  24. Takano A, Shimizu K, Kani S, Buijs R, Okada M, Nagai K. Cloning and characterization of rat casein kinase 1epsilon. FEBS Lett. 2000;477:106-12 pubmed
  25. Meng Q, Logunova L, Maywood E, Gallego M, Lebiecki J, Brown T, et al. Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron. 2008;58:78-88 pubmed publisher
  26. Casagolda D, Del Valle Pérez B, Valls G, Lugilde E, Vinyoles M, Casado Vela J, et al. A p120-catenin-CK1epsilon complex regulates Wnt signaling. J Cell Sci. 2010;123:2621-31 pubmed publisher
    ..Therefore, these results demonstrate a novel and crucial function of p120-catenin in Wnt signaling and unveil additional points of regulation by this factor of ?-catenin transcriptional activity different of ?-catenin stability. ..
  27. Wang Q, Li Y, Zhang Z, Fang Y, Li X, Sun Y, et al. Bioinformatics analysis of gene expression profiles of osteoarthritis. Acta Histochem. 2015;117:40-6 pubmed publisher
    ..The MAPK signaling and Wnt signaling pathways were closely associated with OA. The DEGs, such as PTTG1, MAP2K6, PPP3CC and CSNK1E, may be the potential targets for OA diagnosis and treatment. ..
  28. Krach F, Batra R, Wheeler E, Vu A, Wang R, Hutt K, et al. Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. Acta Neuropathol. 2018;136:405-423 pubmed publisher
    ..Our framework of transcriptome-pathology correlations identifies candidate genes with relevance to novel mechanisms of neurodegeneration. ..
  29. Varghese R, Young S, Pham L, Liang Y, Pridham K, Guo S, et al. Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival. Sci Rep. 2018;8:13621 pubmed publisher
    ..Together, our results demonstrate that CK1? regulates the survival of glioblastoma cells and glioblastoma stem cells through ?-catenin signaling, underscoring the importance of targeting CK1? as an effective treatment for glioblastoma. ..
  30. Kloss B, Price J, Saez L, Blau J, Rothenfluh A, Wesley C, et al. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell. 1998;94:97-107 pubmed
    ..DBT is capable of binding to PER in vitro and in Drosophila cells, suggesting that a physical association of PER and DBT regulates PER phosphorylation and accumulation in vivo. ..
  31. Isojima Y, Nakajima M, Ukai H, Fujishima H, Yamada R, Masumoto K, et al. CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock. Proc Natl Acad Sci U S A. 2009;106:15744-9 pubmed publisher
    ..Most compounds inhibited casein kinase Iepsilon (CKIepsilon) or CKIdelta phosphorylation of the PER2 protein...
  32. Palmieri O, Mazzoccoli G, Bossa F, Maglietta R, Palumbo O, Ancona N, et al. Systematic analysis of circadian genes using genome-wide cDNA microarrays in the inflammatory bowel disease transcriptome. Chronobiol Int. 2015;32:903-16 pubmed publisher
    ..The deregulated genes evidenced by transcriptome analysis in the major IBDs may play a crucial role in the pathophysiological mechanisms and may suggest novel therapeutic approaches. ..
  33. Jayakumar A, Tong X, Shamaladevi N, Barcelona S, Gaidosh G, Agarwal A, et al. Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies. J Neurochem. 2017;140:645-661 pubmed publisher
    ..Read the Editorial Highlight for this article on page 531. ..
  34. Kc R, Li X, VOIGT R, Ellman M, Summa K, Vitaterna M, et al. Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint. J Cell Physiol. 2015;230:2174-2183 pubmed publisher
    ..Our results, for the first time, provide compelling in vivo evidence that environmental disruption of circadian rhythms is a risk factor for the development of OA-like pathological changes in the mouse knee joint. ..
  35. Desagher S, Osen Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, et al. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell. 2001;8:601-11 pubmed
    ..Moreover, a mutant of Bid that cannot be phosphorylated was found to be more toxic than wild-type Bid. Together, these data indicate that phosphorylation of Bid represents a new mechanism whereby cells control apoptosis. ..
  36. Schwarz Romond T, Asbrand C, Bakkers J, Kuhl M, Schaeffer H, Huelsken J, et al. The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 2002;16:2073-84 pubmed
    ..protein Diversin that interacts with two components of the canonical Wnt pathway, Casein kinase Iepsilon (CKIepsilon) and Axin/Conductin...
  37. Rubinfeld B, Tice D, Polakis P. Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J Biol Chem. 2001;276:39037-45 pubmed
    ..beta-catenin regulatory motifs of APC interfered with both axin-dependent phosphorylation and phosphorylation by CKIepsilon and impaired the ability of APC to regulate beta-catenin...
  38. Grozav A, Chikamori K, Kozuki T, Grabowski D, Bukowski R, Willard B, et al. Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity. Nucleic Acids Res. 2009;37:382-92 pubmed publisher
    ..of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein kinase (CK) Idelta and/or CKIepsilon, but not by CKII...
  39. Tiong K, Chang K, Yeh K, Liu T, Wu J, Hsieh P, et al. CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. Neoplasia. 2014;16:441-50 pubmed publisher
    ..Thus the integrated approach is useful in finding novel SL pairs for cancer therapeutics, and it is readily accessible and applicable to other cancers. ..
  40. Lee C, Weaver D, Reppert S. Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004;24:584-94 pubmed
    ..circadian clock function results in part from lack of direct and stable interaction with casein kinase Iepsilon (CKIepsilon)...
  41. Matsunaga S, Ikeda M, Kishi T, Fukuo Y, Aleksic B, Yoshimura R, et al. An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders. Neurosci Lett. 2012;529:66-9 pubmed publisher
    ..21) and BD (P=0.53). These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population. ..
  42. Mansour H, Talkowski M, Wood J, Chowdari K, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701-10 pubmed publisher
    ..5. Additional analyses using adequately powered samples are warranted to further evaluate these results. ..
  43. Singh S, Gupta D. A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis. J Theor Biol. 2015;371:59-68 pubmed publisher
    ..Further, this paper as a first effort to concurrently study all the three isoforms of CK1 provides structural basis for development of common anticancer therapeutics against three isoforms of CK1. ..
  44. Young E, Bryant C, Lee S, Peng X, Cook B, Nair H, et al. Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test. Genes Brain Behav. 2016;15:604-15 pubmed publisher
    ..Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation. ..
  45. Hino S, Michiue T, Asashima M, Kikuchi A. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. J Biol Chem. 2003;278:14066-73 pubmed
    We demonstrate that Dvl-1, casein kinase I epsilon (CKI epsilon), and Frat-1 activate the Wnt signaling pathway cooperatively...
  46. Huang Y, Li J, Wu L, Jin Q, Zhao X, Li J, et al. Association between a casein kinase 1 ? gene polymorphism and schizophrenia in a Chinese Han population. J Mol Neurosci. 2012;47:470-4 pubmed publisher
    ..0032; OR?=?1.532; 95% CI, 1.153-2.037), suggesting that a genetic variant in the Csnk1? gene significantly enhances the probability of schizophrenia in the Chinese Han population. ..
  47. Xu F, Wang Y, Chang J, Du S, Diao L, Jiang N, et al. Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/?-catenin signalling pathway by directly binding casein kinase 1?. Biochem J. 2014;458:159-69 pubmed publisher
    ..Therefore the results of the present study revealed that, in addition to the phosphorylated YAP/TAZ, the Hippo pathway can suppress the Wnt/?-catenin pathway directly through MST1/2. ..
  48. Militi S, Maywood E, Sandate C, Chesham J, Barnard A, Parsons M, et al. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking. Proc Natl Acad Sci U S A. 2016;113:2756-61 pubmed publisher
    ..These periods are unprecedented in mice. Thus, Per2(Edo) reveals a direct causal link between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping. ..
  49. Chu L, Zhu Y, Yu K, Zheng T, Yu H, Zhang Y, et al. Variants in circadian genes and prostate cancer risk: a population-based study in China. Prostate Cancer Prostatic Dis. 2008;11:342-8 pubmed
    ..5, 95% CI, 0.3-1.0) as compared to the GG genotype. Our findings, although in need of confirmation, suggest that variations in circadian genes may alter prostate cancer risk and some biological processes may modify this effect. ..
  50. Castro R, Barbosa A, Pedrazzoli M, Tufik S. Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. Behav Brain Res. 2008;193:156-7 pubmed publisher
    ..Therefore, it is necessary to account for adaptative influences in genetic background, analyzing different groups with different photoperiods, to validate the effects of this and other polymorphisms on sleep and circadian disorders. ..
  51. Gutiérrez Monreal M, Villela L, Baltazar S, Perfecto Avalos Y, Cardineau G, Scott S. A PER3 polymorphism is associated with better overall survival in diffuse large B-cell lymphoma in Mexican population. Cancer Biomark. 2015;15:699-705 pubmed publisher
    ..001) also showed differences in overall survival. No clinical differences were observed in mutated vs. non-mutated patients. This work suggests a role of PER3 rs10462020 in predicting a prognosis in DLBCL overall survival of patients. ..
  52. Morgenstern Y, Das Adhikari U, Ayyash M, Elyada E, Tóth B, Moor A, et al. Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance. EMBO J. 2017;36:3046-3061 pubmed publisher
    ..Our study underscores a unique regulation mode of the Wnt pathway in ISCs, possibly providing new means of stem cell enrichment for regenerative medicine. ..
  53. Mocellin S, Tropea S, Benna C, Rossi C. Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies. BMC Med. 2018;16:20 pubmed publisher
    ..Our findings, based on the largest series ever utilized for ARTP-based gene and pathway analysis, support the hypothesis that circadian pathway genetic variation is involved in cancer predisposition. ..
  54. Liu C, Zha Z, Zhou X, Zhang H, Huang W, Zhao D, et al. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010;285:37159-69 pubmed publisher
    ..The phosphodegron-mediated TAZ degradation plays an important role in negatively regulating TAZ biological functions. ..
  55. Xu P, Fischer Posovszky P, Bischof J, Radermacher P, Wabitsch M, Henne Bruns D, et al. Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin. Mol Cell Endocrinol. 2015;406:87-101 pubmed publisher
    ..In summary, our data indicate that site-specific phosphorylation of adiponectin, especially at sites targeted by CK1δ in vitro, provides an additional regulatory mechanism for modulating adiponectin complex formation and function. ..
  56. Hämmerlein A, Weiske J, Huber O. A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex. Cell Mol Life Sci. 2005;62:606-18 pubmed
  57. Okamura A, Iwata N, Nagata A, Tamekane A, Shimoyama M, Gomyo H, et al. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. Blood. 2004;103:2997-3004 pubmed
    Two closely related casein kinase I (CKI) isoforms, CKIdelta and CKIepsilon, are ubiquitously expressed in many human tissues, but their specific biologic function remains to be clarified...
  58. Wang X, Goode E, Fredericksen Z, Vierkant R, Pankratz V, Liu Mares W, et al. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2101-8 pubmed publisher
  59. Lavebratt C, Sjöholm L, Partonen T, Schalling M, Forsell Y. PER2 variantion is associated with depression vulnerability. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:570-581 pubmed publisher
    ..In conclusion, genetic variation in PER2 is associated with depression vulnerability a Swedish population-based sample. More studies are needed to determine if this is the case also for NPAS2, ARNTL, and RORA. ..
  60. Shimizu K, Fukushima H, Ogura K, Lien E, Nihira N, Zhang J, et al. The SCF?-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017;10: pubmed publisher
    ..Together, these data reveal a critical physiological function of ?-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 stability. ..
  61. Kotaka T, Ujike H, Morita Y, Kishimoto M, Okahisa Y, Inada T, et al. Association study between casein kinase 1 epsilon gene and methamphetamine dependence. Ann N Y Acad Sci. 2008;1139:43-8 pubmed publisher
    Casein kinase 1 epsilon (CKIepsilon) is a component of the DARPP-32 in second-messenger pathway...
  62. Piao S, Lee S, Xu Y, Gwak J, Oh S, Park B, et al. CK1? targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation. Cell Cycle. 2011;10:531-7 pubmed
    ..Taken together, our results indicate that CK1? regulates the cellular levels of Cdc25A in parallel with Chk1-dependent Cdc25A degradation, contributing to the precise control of cell division. ..
  63. Kategaya L, Hilliard A, Zhang L, Asara J, Ptacek L, Fu Y. Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock. PLoS ONE. 2012;7:e31987 pubmed publisher
    ..Thus, isolating CK1 protein complexes led to the identification of PHB2 as an inhibitor of circadian transcription. Furthermore, we show that CK1? and CK1? differentially regulate the expression of PHB2. ..
  64. Levran O, Londono D, O Hara K, Nielsen D, Peles E, Rotrosen J, et al. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes Brain Behav. 2008;7:720-9 pubmed publisher
    ..0005). None of these associations remained significant after adjustment for multiple testing. This study suggests the involvement of several genes and variants in heroin addiction, which is worthy of future study. ..
  65. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010;18:147-59 pubmed publisher
    ..Our results provide insight into the signaling pathways controlling Mdm2 destruction and further suggest that compromised regulation of Mdm2 results in attenuated p53 activity, thereby facilitating tumor progression. ..
  66. Cajanek L, Ganji R, Henriques Oliveira C, Theofilopoulos S, Konik P, Bryja V, et al. Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol. 2013;33:59-70 pubmed publisher
    ..In summary, our data identify Tiam1 as a novel regulator of DA neuron development and as a Dvl-associated and Rac1-specific GEF acting in the Wnt/Dvl/Rac1 pathway. ..
  67. Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, et al. CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci. 2014;127:1242-53 pubmed publisher
    ..Together, these data demonstrate that CK1? and CK1? play a decisive role in triggering late steps of pre-40S maturation that are required for acquisition of functionality of 40S ribosomal subunits in protein translation. ..
  68. Magliozzi R, Kim J, Low T, Heck A, Guardavaccaro D. Degradation of Tiam1 by casein kinase 1 and the SCF?TrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. J Biol Chem. 2014;289:27400-9 pubmed publisher
    ..We propose that the SCF(?TrCP)-mediated degradation of Tiam1 controls the duration of the mTOR-S6K signaling pathway in response to mitogenic stimuli. ..
  69. López Guerra J, Verdugo Sivianes E, Otero Albiol D, Vieites B, Ortiz Gordillo M, De León J, et al. High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer. Oncotarget. 2015;6:30343-56 pubmed publisher
  70. Gietzen K, Virshup D. Identification of inhibitory autophosphorylation sites in casein kinase I epsilon. J Biol Chem. 1999;274:32063-70 pubmed
    Casein kinase I epsilon (CKIepsilon) is a widely expressed protein kinase implicated in the regulation of diverse cellular processes including DNA replication and repair, nuclear trafficking, and circadian rhythm...
  71. Sillibourne J, Milne D, Takahashi M, Ono Y, Meek D. Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450. J Mol Biol. 2002;322:785-97 pubmed
  72. Ha N, Tonozuka T, Stamos J, Choi H, Weis W. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell. 2004;15:511-21 pubmed
    ..Phosphorylated APC and axin bind to the same surface of, and compete directly for, beta-catenin. The structural and biochemical data suggest a novel model for how APC functions in beta-catenin degradation. ..
  73. Kannanayakal T, Tao H, Vandre D, Kuret J. Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions. Acta Neuropathol. 2006;111:413-21 pubmed
    ..They also suggest a nexus between the phosphorylation and ubiquitination modifications found in both lesions. ..
  74. Partch C, Shields K, Thompson C, Selby C, Sancar A. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5. Proc Natl Acad Sci U S A. 2006;103:10467-10472 pubmed publisher
    ..Here we show that protein phosphatase (PP) 5 regulates the kinase activity of CKIepsilon. We demonstrate that cryptochrome regulates clock protein phosphorylation by modulating the effect of PP5 on ..
  75. Sekine T, Yamaguchi T, Hamano K, Young M, Shimoda M, Saez L. Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock. J Biol Rhythms. 2008;23:3-15 pubmed publisher
    ..Thus, caution should be used in interpreting assays that measure activity of mammalian casein kinase mutants in Drosophila, or that employ vertebrate CKI in studies of dPER phosphorylations. ..
  76. Modak C, Bryant P. Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines. Biochem Biophys Res Commun. 2008;368:801-7 pubmed publisher
    ..Here we show that, expression of Casein Kinase I epsilon (CKIepsilon) causes up-regulation of the Akt pathway despite normal protein expression of the pathway inhibitor phosphate ..
  77. Chu L, Zhu Y, Yu K, Zheng T, Chokkalingam A, Stanczyk F, et al. Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I. Cancer Epidemiol Biomarkers Prev. 2008;17:3268-73 pubmed publisher
    ..Our findings, although in need of confirmation, suggest that variations in circadian genes are associated with serum hormone levels, providing biological support for the role of circadian genes in hormone-related cancers. ..
  79. Goldberg L, Kirkpatrick S, Yazdani N, Luttik K, Lacki O, Babbs R, et al. Casein kinase 1-epsilon deletion increases mu opioid receptor-dependent behaviors and binge eating1. Genes Brain Behav. 2017;16:725-738 pubmed publisher
    ..To summarize, Csnk1e deletion increased mu opioid receptor-dependent behaviors, supporting previous studies indicating an endogenous negative regulatory role of Csnk1e in opioid behavior. ..
  80. Vielhaber E, Eide E, Rivers A, Gao Z, Virshup D. Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol. 2000;20:4888-99 pubmed
    ..The Drosophila double-time gene product, a casein kinase I epsilon (CKIepsilon) homolog, has been reported to interact with dPER and regulate circadian cycle length...
  81. Zhang Y, Qiu W, Chan S, Han J, He X, Lin S. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. J Biol Chem. 2002;277:17706-12 pubmed
    ..In the present study, we show that the Wnt activator CKIepsilon, but not CKIIalpha, Frat1, LRP5, or LRP6, inhibited Axin-mediated JNK activation...
  82. Okamura A, Iwata N, Tamekane A, Yakushijin K, Nishikawa S, Hamaguchi M, et al. Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells. Life Sci. 2006;78:1624-9 pubmed
    ..Introduction of wild-type (WT)-CKIepsilon into interleukin-3 (IL-3)-dependent 32D cells increased the sensitivity to genotoxic stresses, such as gamma-..
  83. Gallego M, Eide E, Woolf M, Virshup D, Forger D. An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proc Natl Acad Sci U S A. 2006;103:10618-23 pubmed
    ..A widely studied mutation in casein kinase I (CKI), the CKIepsilon(tau) mutant, has been shown to cause a loss of kinase function in vitro, but it has been difficult to reconcile ..
  84. Zhu Y, Stevens R, Hoffman A, FitzGerald L, Kwon E, Ostrander E, et al. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res. 2009;69:9315-22 pubmed publisher
  85. Utge S, Soronen P, Loukola A, Kronholm E, Ollila H, Pirkola S, et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE. 2010;5:e9259 pubmed publisher
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation. ..
  86. Del Valle Pérez B, Casagolda D, Lugilde E, Valls G, Codina M, Dave N, et al. Wnt controls the transcriptional activity of Kaiso through CK1?-dependent phosphorylation of p120-catenin. J Cell Sci. 2011;124:2298-309 pubmed publisher
  87. Lee K, Johmura Y, Yu L, Park J, Gao Y, Bang J, et al. Identification of a novel Wnt5a-CK1?-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 2012;31:3104-17 pubmed publisher
    ..This study may provide new insights into the mechanism underlying ciliary disassembly processes and various cilia-related disorders. ..
  88. Wang Y, Zhu Y, Wang W, Wu F, Cui H, Xun X, et al. A population-based association study of casein kinase 1 epsilon loci with heroin dependence in Han Chinese. J Mol Neurosci. 2014;53:143-9 pubmed publisher
    ..These findings point to a role for Csnk1? polymorphisms in heroin dependence among the Han Chinese population and may be informative for future genetic or neurobiological studies on heroin dependence. ..
  89. Kaneko N, Hwang J, Gertner M, Pontarelli F, Zukin R. Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death. J Neurosci. 2014;34:6030-9 pubmed publisher
    ..These findings point to CK1 as a potential therapeutic target for the amelioration of hippocampal injury and cognitive deficits associated with global ischemia. ..
  90. Levran O, Peles E, Randesi M, Correa Da Rosa J, Ott J, Rotrosen J, et al. Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants. Pharmacogenomics. 2014;15:2001-9 pubmed publisher
    ..It may be a target for drug addiction treatment. Original submitted 8 August 2014; Revision submitted 8 October 2014. ..
  91. Zhou Y, He C, Yan D, Liu F, Liu H, Chen J, et al. The kinase CK1É› controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3. Nat Immunol. 2016;17:397-405 pubmed publisher
    ..Our findings establish CK1É› as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1É›-mediated phosphorylation of TRAF3. ..
  92. Keesler G, Camacho F, Guo Y, Virshup D, Mondadori C, Yao Z. Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. Neuroreport. 2000;11:951-5 pubmed
    ..hPER I protein could also be co-immunoprecipitated with transfected hCKI epsilon as well as endogenous hCKI epsilon, indicating physical association between hPER I and hCKI epsilon proteins in vivo. ..