CIB1

Summary

Gene Symbol: CIB1
Description: calcium and integrin binding 1
Alias: CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin-binding protein 1, DNA-PK interaction protein, DNA-PKcs-interacting protein, DNA-dependent protein kinase interacting protein, SNK-interacting protein 2-28, calcium and integrin binding 1 (calmyrin), testicular secretory protein Li 9
Species: human
Products:     CIB1

Top Publications

  1. Stabler S, Ostrowski L, Janicki S, Monteiro M. A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein. J Cell Biol. 1999;145:1277-92 pubmed
    ..Functionally, calmyrin and PS2 increase cell death when cotransfected into HeLa cells. These results allude to several provocative possibilities for a dynamic role of calmyrin in signaling, cell death, and AD. ..
  2. Naik U, Patel P, Parise L. Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J Biol Chem. 1997;272:4651-4 pubmed
    ..The open reading frame encodes a novel 191-amino acid polypeptide (termed CIB for calcium- and integrin-binding protein) that appears to be specific for the cytoplasmic domain of alphaIIb, ..
  3. Wu X, Lieber M. Interaction between DNA-dependent protein kinase and a novel protein, KIP. Mutat Res. 1997;385:13-20 pubmed
    ..We discuss the interaction of DNA-PKcs with this novel calcium-binding protein family member in the context of possible kinase-phosphatase regulation of DNA end joining. ..
  4. Yamniuk A, Nguyen L, Hoang T, Vogel H. Metal ion binding properties and conformational states of calcium- and integrin-binding protein. Biochemistry. 2004;43:2558-68 pubmed
    Calcium- and integrin-binding protein (CIB) is a novel member of the helix-loop-helix family of regulatory calcium-binding proteins which likely has a specific function in hemostasis through its interaction with platelet integrin ..
  5. Tsuboi S, Nonoyama S, Ochs H. Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion. EMBO Rep. 2006;7:506-11 pubmed
    ..Here, we show that WASP binds to the calcium- and integrin-binding protein (CIB) in platelets...
  6. Yoon K, Cho J, Lee J, Kang Y, Chae J, Kim Y, et al. CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A. 2009;106:17389-94 pubmed publisher
    b>Calcium and integrin binding protein 1 (CIB1) is a Ca(2+)-binding protein of 22 kDa that was initially identified as a protein that interacts with integrin alpha(IIb)...
  7. Jarman K, Moretti P, Zebol J, Pitson S. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J Biol Chem. 2010;285:483-92 pubmed publisher
    ..Here, we demonstrate a direct role for CIB1 (calcium and integrin-binding protein 1) in this process...
  8. Naik M, Pham N, Beebe K, Dai W, Naik U. Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. Int J Cancer. 2011;128:587-96 pubmed publisher
    ..Here, we show that calcium- and integrin-binding protein 1 (CIB1), a Plk3 interacting protein, is widely expressed in various cancer cell lines...
  9. Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, et al. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J. 1999;18:5528-39 pubmed
    ..Moreover, a conserved C-terminal domain in these kinases is shown to interact specifically with Cib, a Ca(2+)- and integrin-binding protein...

More Information

Publications112 found, 100 shown here

  1. Barry W, Boudignon Proudhon C, Shock D, McFadden A, Weiss J, Sondek J, et al. Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. J Biol Chem. 2002;277:28877-83 pubmed
    ..We previously identified a 22-kDa, EF-hand-containing protein, CIB, which binds to the alpha(IIb) cytoplasmic tail of the platelet integrin, alpha(IIb)beta(3)...
  2. Naik U, Naik M. Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. Blood. 2003;102:1355-62 pubmed
    ..Here we demonstrate that an association between GPIIb/IIIa and calcium- and integrin-binding protein (CIB) is required for the process of platelet spreading...
  3. Gentry H, Singer A, Betts L, Yang C, Ferrara J, Sondek J, et al. Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins. J Biol Chem. 2005;280:8407-15 pubmed
    b>CIB1 (CIB) is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alphaIIbbeta3 integrin and several serine/threonine kinases and potentially modulates their function...
  4. Leisner T, Liu M, Jaffer Z, Chernoff J, Parise L. Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol. 2005;170:465-76 pubmed
    ..In this study, we report a direct and specific interaction of PAK1 with a 22-kD Ca2+-binding protein, CIB1, which results in PAK1 activation both in vitro and in vivo...
  5. Hollenbach A, McPherson C, Lagutina I, Grosveld G. The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3. Biochim Biophys Acta. 2002;1574:321-8 pubmed
    ..These results therefore suggest potential ways in which calcium, through its regulation of the EF-hand calcium-binding protein calmyrin, can alter the DNA-binding activity and subsequent transcriptional activity of Pax3. ..
  6. Zhu J, Stabler S, Ames J, Baskakov I, Monteiro M. Calcium binding sequences in calmyrin regulates interaction with presenilin-2. Exp Cell Res. 2004;300:440-54 pubmed
    ..Our results suggest that calmyrin functions as a calcium sensor and that calcium binding sequences in calmyrin are important for interaction with the PS2 loop. ..
  7. Yuan W, Leisner T, McFadden A, Wang Z, Larson M, Clark S, et al. CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation. J Cell Biol. 2006;172:169-75 pubmed
    ..We report that calcium and integrin binding protein 1 (CIB1), which interacts directly with the alphaIIb tail, is an endogenous inhibitor of ..
  8. Haataja L, Kaartinen V, Groffen J, Heisterkamp N. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. J Biol Chem. 2002;277:8321-8 pubmed
    ..A role for Rac3 in integrin-mediated adhesion and spreading has not been defined. We here report that CIB, a protein that binds to the alpha(IIb)beta(3) fibrinogen receptor, interacts exclusively with activated (V12) Rac3 ..
  9. Naik M, Naik U. Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Blood. 2003;102:3629-36 pubmed
    ..Previously, we have shown that, when bound to glycoprotein IIb (GPIIb), calcium- and integrin-binding protein (CIB) regulates platelet spreading on immobilized fibrinogen (Fg)...
  10. White C, Yang J, Monteiro M, Foskett J. CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel. J Biol Chem. 2006;281:20825-33 pubmed
    ..We have discovered the Ca(2+)-binding protein CIB1 (calmyrin) as a ubiquitously expressed ligand of the InsP(3)R...
  11. Naik M, Naik U. Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling. J Cell Biochem. 2011;112:3289-99 pubmed publisher
    Calcium- and integrin-binding protein 1 (CIB1) has been shown to be involved in cell spreading and migration. The signaling events regulated by CIB1 during cell migration are poorly understood...
  12. Roskoski R. Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. Pharmacol Res. 2019;139:471-488 pubmed publisher
    ..As inhibitors of the cell cycle, it is not surprising that one of their most common toxicities is myelosuppression with decreased neutrophil production. ..
  13. Prasad R, Katiyar S. Bioactive phytochemical proanthocyanidins inhibit growth of head and neck squamous cell carcinoma cells by targeting multiple signaling molecules. PLoS ONE. 2012;7:e46404 pubmed publisher
    ..Cyclin D2) and cyclin-dependent kinases (Cdk), (iii) increased expression of the Cdk inhibitory proteins (Cip1/p21, Kip1/p27), enhanced binding of Cdk inhibitors to Cdks, and downregulation of E2F transcription factor...
  14. Roskoski R. Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs. Pharmacol Res. 2016;107:249-275 pubmed publisher
    ..As inhibitors of the cell cycle, it is not surprising that one of their most common toxicities is myelosuppression with decreased neutrophil production. ..
  15. Starenki D, Hong S, Lloyd R, Park J. Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. Oncogene. 2015;34:4624-34 pubmed publisher
    ..and altered expression of cell cycle regulatory machinery and apoptosis markers, including E2F-1, p21(CIP1), p27(KIP1) and Bcl-2 family proteins...
  16. Li J, Yang Y, Liu Q, Zhou Z, Pan S, He Z, et al. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells. Drug Des Devel Ther. 2015;9:1027-62 pubmed publisher
    ..accompanied by the downregulation of cyclin-dependent kinase 1 and cyclin B1 and upregulation of p21 Waf1/Cip1, p27 Kip1, and p53...
  17. Yu D, Gernapudi R, Drucker C, Sarkar R, Ucuzian A, Monahan T. The myristoylated alanine-rich C kinase substrate differentially regulates kinase interacting with stathmin in vascular smooth muscle and endothelial cells and potentiates intimal hyperplasia formation. J Vasc Surg. 2019;: pubmed publisher
    ..MARCKS knockdown decreases expression of the kinase interacting with stathmin (KIS), increasing p27kip1 expression, arresting VSMC proliferation...
  18. Pacini L, Savini C, Ghittoni R, Saidj D, Lamartine J, Hasan U, et al. Downregulation of Toll-Like Receptor 9 Expression by Beta Human Papillomavirus 38 and Implications for Cell Cycle Control. J Virol. 2015;89:11396-405 pubmed publisher
    ..expression of TLR9 in HPV38 E6/E7 cells resulted in an accumulation of the cell cycle inhibitors p21(WAF1) and p27(Kip1), decreased CDK2-associated kinase activity, and inhibition of cellular proliferation...
  19. Barzegar M, Ma S, Zhang C, Chen X, Gu Y, Shang C, et al. SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling. Br J Cancer. 2017;117:1154-1163 pubmed publisher
    ..and upregulating the expression of cyclin-dependent kinase (CDK) inhibitors (p21Cip1 and p27Kip1), leading to decreased phosphorylation of Rb...
  20. Liu D, Pattabiraman V, Bacanamwo M, Anderson L. Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase transition in vascular smooth muscle cells by CDK2-dependent activation. Am J Physiol Cell Physiol. 2016;311:C179-89 pubmed publisher
    ..Quantitative RT-PCR results revealed modulation of cyclin-dependent kinase inhibitor 1B (p27(kip1)), E2F transcription factor 1 (E2f1), and proliferating cell nuclear antigen (Pcna) expression in Irx5-transduced ..
  21. Pan S, Qin Y, Zhou Z, He Z, Zhang X, Yang T, et al. Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells. Drug Des Devel Ther. 2015;9:1601-26 pubmed publisher
    ..division cycle protein 2 homolog (Cdc2) and cyclin B1 and increase in the expression level of p21 Waf1/Cip1, p27 Kip1, and p53 in SCC25 cells. PLB markedly induced apoptosis and autophagy in SCC25 cells...
  22. He Y, Cai C, Tang D, Sun S, Li H. Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts. Front Cell Neurosci. 2014;8:382 pubmed publisher
    ..TSA or VPA treatment caused a significant decrease in the percentage of S-phase cells and induced p21(Cip1) and p27(Kip1) expression, both of which are likely to explain the decrease in the amount of newly regenerated hair cells in ..
  23. Kumar B, Chandran B. KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses. 2016;8: pubmed
    ..pathways which results in the simultaneous induction of FAK, Src, PI3-K, Rho-GTPase, ROS, Dia-2, PKC ?, c-Cbl, CIB1, Crk, p130Cas and GEF-C3G signal and adaptor molecules that play critical roles in the modulation of membrane and ..
  24. Seltzer J, Ashton C, Scotton T, Pangal D, Carmichael J, Zada G. Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature. Neurosurg Focus. 2015;38:E17 pubmed publisher
    ..genes/proteins found to be underexpressed in ACTH-PAs relative to the normal pituitary gland included CDKN1B/p27(Kip1), CDKN2A/p16, KISS1/kisspeptin, ACTHR/ACTH-R, and miR-493...
  25. Kang J, Kim S, Kim M, Boo H, Kim E, Im G, et al. Effects of dihydrotestosterone on rat dermal papilla cells in vitro. Eur J Pharmacol. 2015;757:74-83 pubmed publisher
    ..revealed that DHT increased cell-cycle arrest in these cells, which was accompanied by an increase in the p27(kip1) level and by decreases in cyclin E, cyclin D1, and cyclin-dependent kinase 2 levels...
  26. Seifert A, Posern G. Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Breast Cancer Res. 2017;19:68 pubmed publisher
    ..These phenotypes correlate with deregulated expression of cell cycle inhibitors p21/Waf1, p27/Kip1 and altered phosphorylation of retinoblastoma protein...
  27. Bermudez T, Souza A. Can emotional content reduce the age gap in visual working memory? Evidence from two tasks. Cogn Emot. 2017;31:1676-1683 pubmed publisher
    ..Young and older adults completed a serial image recognition (SIR) task and a colour-image binding (CIB) task...
  28. Li J, Vervoorts J, Carloni P, Rossetti G, Luscher B. Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant. BMC Bioinformatics. 2017;18:15 pubmed publisher
    ..amino acids beyond the minimal consensus sequence of the well-studied substrate and tumor suppressor p27KIP1 were relevant for catalysis...
  29. Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher
    ..important for integrin activation and delivery of matrix metalloproteinases: through the upstream recruiter CIB1 as well as the downstream effector GIT1...
  30. Tazat K, Harsat M, Goldshmid Shagal A, Ehrlich M, Henis Y. Dual effects of Ral-activated pathways on p27 localization and TGF-? signaling. Mol Biol Cell. 2013;24:1812-24 pubmed publisher
    ..in several ways, one of which is cytoplasmic mislocalization of the cyclin-dependent kinase inhibitor p27(Kip1) (p27)...
  31. Gonçalves G. p27kip1 as a key regulator of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2018;221:1-4 pubmed publisher
    p27kip1 as a key regulator of endometriosis Gonçalves GA p27kip1 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G1 destruction allows progression of the cell across the G1/S boundary...
  32. Yamagishi R, Tsusaka T, Mitsunaga H, Maehata T, Hoshino S. The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. Nucleic Acids Res. 2016;44:2475-90 pubmed publisher
    ..show that QKI-7 specifically promotes polyadenylation and translation of three natural target mRNAs (hnRNPA1, p27(kip1)and β-catenin) in a manner that is dependent on the QKI response element...
  33. Grieve S, Gao Y, Hall C, Hu J, Greer P. Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis. Mol Cell Biol. 2016;36:2078-88 pubmed publisher
    ..D1 and AKT and multidrug resistance protein 2, which correlated with increased expression of antimitogenic p27(KIP1) and proapoptotic BIM proteins. Like other therapeutics, 17AAG can be effluxed by specific ABC transporters...
  34. Miao X, Xu X, Wu Y, Zhu X, Chen X, Li C, et al. Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma. Tumour Biol. 2016;37:1369-78 pubmed publisher
    ..of lymphoma cells to fibronectin (FN) decreased TRIP6 expression, which led to the upregulation of nuclear p27(Kip1) expression by decreasing phosphorylation of p27(Kip1) at T157...
  35. Wang D, Yang S, Chen X, Shen H, Luo L, Zhang X, et al. miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27kip1 pathway. Tumour Biol. 2016;37:15315-15324 pubmed
    ..many cancer types, in this study, we aimed to investigate its efficacy in breast cancer through PTEN/Akt/p27 kip1 pathway...
  36. Gummlich L, Kähne T, Naumann M, Kilic E, Jung K, Dubiel W. New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers. Int Rev Cell Mol Biol. 2016;323:181-229 pubmed publisher
    ..CSN-CRL pathway components in RCC patient samples and four RCC cell lines revealed an interesting deregulated p27(Kip1)-Skp2-CAND1 axis and two p27(Kip1) point mutations in 786-O cells; p27(Kip1)V109G and p27(Kip1)I119T...
  37. Nojima H, Kuboki S, Shinoda K, Shimizu H, Ohtsuka M, Kato A, et al. Activation of peroxisome proliferator-activated receptor-gamma inhibits tumor growth by negatively regulating nuclear factor-?B activation in patients with hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2016;23:574-84 pubmed publisher
    ..PPAR? activation inhibited cell proliferation by inducing cell cycle arrest, through increased expression of p27(kip1) and decreased expression of cyclin D1 and interleukin-8...
  38. Nguyen H, Tilton S, Kemp C, Song M. Nonmonotonic Pathway Gene Expression Analysis Reveals Oncogenic Role of p27/Kip1 at Intermediate Dose. Cancer Inform. 2017;16:1176935117740132 pubmed publisher
    The mechanistic basis by which the level of p27Kip1 expression influences tumor aggressiveness and patient mortality remains unclear...
  39. Taslimi A, Zoltowski B, Miranda J, Pathak G, Hughes R, Tucker C. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol. 2016;12:425-30 pubmed publisher
    ..adapted for use in controlling protein-protein interactions through light-dependent binding to a partner protein, CIB1. While the existing CRY2-CIB dimerization system has been used extensively for optogenetic applications, some ..
  40. Naik M, Naik T, Summer R, Naik U. Binding of CIB1 to the ?IIb tail of ?IIb?3 is required for FAK recruitment and activation in platelets. PLoS ONE. 2017;12:e0176602 pubmed publisher
    ..The involvement of ?IIb in outside-in signaling is poorly understood. We have previously shown that CIB1 specifically interacts with the cytoplasmic domain of ?IIb and is required for ?IIb?3 outside-in signaling...
  41. Liu C, Qi X, Yang Y, Zhang X. Betulinic acid inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition. Biomed Pharmacother. 2016;80:338-342 pubmed publisher
    ..arrested HG-induced cell-cycle progression, reversed HG-inhibited expression of p21(Waf1/Cip1) and p27(Kip1). It also suppressed HG-induced fibronectin (FN) expression in MCs...
  42. Xie W, Qin W, Kang Y, Zhou Z, Qin A. MicroRNA-340 Inhibits Tumor Cell Proliferation and Induces Apoptosis in Endometrial Carcinoma Cell Line RL 95-2. Med Sci Monit. 2016;22:1540-6 pubmed
    ..01). However, suppression of miR-340 had opposite results. Moreover, the protein levels of p27 KIP1, Bax, pro-Caspase 3, and active-Caspase-3 were significantly increased by overexpression of miR-340 but were ..
  43. He B, Xu Z, Chen J, Zheng D, Li A, Zhang L. Upregulated microRNA-143 inhibits cell proliferation in human nasopharyngeal carcinoma. Oncol Lett. 2016;12:5023-5028 pubmed publisher
    ..The expression levels of p21Cip1, p27Kip1, cyclin D1, phosphorylated (p)-retinoblastoma protein (Rb), Rb and cyclin-dependent kinase (CDK) 6 were ..
  44. Grahek M, Ptak A, Kalyuzhny A. High-Sensitivity IHC Detection of Phosphorylated p27/Kip1 in Human Tissues Using Secondary Antibody Conjugated to Polymer-HRP. Methods Mol Biol. 2017;1554:211-218 pubmed publisher
    ..was used to develop rapid and highly sensitive immunostaining protocol for the detection of phosphorylated p27/Kip1 (T157) in human tissues...
  45. Hydbring P, Castell A, Larsson L. MYC Modulation around the CDK2/p27/SKP2 Axis. Genes (Basel). 2017;8: pubmed publisher
    ..Among these are the cyclin E/A/cyclin-dependent kinase 2 (CDK2) complexes, the CDK inhibitor p27KIP1 (p27) and the E3 ubiquitin ligase component S-phase kinase-associated protein 2 (SKP2), which control each ..
  46. Rostama B, Turner J, Seavey G, Norton C, Gridley T, Vary C, et al. DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1. Arterioscler Thromb Vasc Biol. 2015;35:2626-37 pubmed publisher
    ..BMP9/DLL4 required induction of P27(KIP1) for quiescence, although multiple factors are involved...
  47. Liu Y, Wang F, Liu Y, Yao Y, Lv X, Dong B, et al. RNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway. Sci Rep. 2016;6:20642 pubmed publisher
    ..By lowering RNF135 expression, phosphorylated Erk and cell cycle protein CDK4 were down-regulated, while p27(Kip1) and p21(Waf1/Cip1) were up-regulated in U87 and U251 cells in vitro...
  48. Ankri Eliahoo G, Weitz K, Cox T, Tang G. p27(kip1) Knockout enhances collateralization in response to hindlimb ischemia. J Vasc Surg. 2016;63:1351-9 pubmed publisher
    ..The gene p27(Kip1) (p27) affects human response to arterial injury...
  49. Yıldırım Buharalıoğlu G, Bond M, Sala Newby G, Hindmarch C, Newby A. Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-? and Interleukin-4 in Human Macrophages. Front Immunol. 2017;8:92 pubmed publisher
    ..Rendering macrophages quiescent by growth factor starvation or adenovirus-mediated overexpression of p27kip1 inhibited expression of AURKB, ESCO2, SUV39H1, and WHSC1, and mRNA levels were restored by overexpressing the ..
  50. Zhao W, Dai Y, Dai T, Xie T, Su X, Li J, et al. TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a. Biochem Biophys Res Commun. 2017;494:594-601 pubmed publisher
    ..of TRIP6 leaded to the decreased expression of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and increased expression of the cell cycle regulator cyclin D1...
  51. Shi H, Gong H, Cao K, Zou S, Zhu B, Bao H, et al. Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1). J Neurooncol. 2015;124:357-64 pubmed publisher
    ..that Nrdp1 decreased the level of ErbB3, which resulted in decreasing p-AKT thereby reducing cytoplasmic p27(Kip1)...
  52. Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, et al. MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic ?-Cell Proliferation. EBioMedicine. 2017;15:163-172 pubmed publisher
    ..Thus, these identified miRNAs may lead to the development of therapeutic strategies for diabetes. ..
  53. Purba T, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, et al. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. Eur J Cell Biol. 2017;96:632-641 pubmed publisher
    ..CIP/KIP family member proteins (p21CIP1, p27KIP1 and p57KIP2) regulate cell cycle progression/arrest, endoreplication, differentiation and ..
  54. Shen Q, Eun J, Lee K, Kim H, Yang H, Kim S, et al. BANF1, PLOD3, SF3B4 as Early-stage Cancer Decision Markers and Drivers of Hepatocellular Carcinoma. Hepatology. 2017;: pubmed publisher
    ..This contributes to malignant transformation and growth of hepatocyte via transcriptional inactivation of p27Kip1 and simultaneously activation of Slug genes.
  55. Jatzek A, Tejera M, Singh A, Sullivan J, Plisch E, Suresh M. p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. J Immunol. 2012;189:5119-28 pubmed publisher
    ..Our studies ascribe a novel role for the cell cycle regulator p27(Kip1) as a prominent negative regulator of the establishment and long-term maintenance of Th1 CD4 T cell memory...
  56. Khadka P, Lee J, Baek S, Oh S, Chung I. DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres. Biochem J. 2014;463:19-30 pubmed publisher
    ..Thus KIP represents a new pathway for modulating telomerase and telomere function in cancer. ..
  57. Das R, Huang Y, Phillips A, Kriwacki R, Pappu R. Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling. Proc Natl Acad Sci U S A. 2016;113:5616-21 pubmed publisher
    ..of motifs? We answer this question using the polyampholytic C-terminal IDR of the cell cycle inhibitory protein p27(Kip1) (p27). Phosphorylation of Thr-187 (T187) within the p27 IDR controls entry into S phase of the cell division cycle...
  58. Natori T, Fujiyoshi M, Uchida M, Abe N, Kanaki T, Fukumoto Y, et al. Growth arrest of vascular smooth muscle cells in suspension culture using low-acyl gellan gum. In Vitro Cell Dev Biol Anim. 2017;53:191-198 pubmed publisher
    ..suspension with GG, the ratio of phosphorylated retinoblastoma (Rb) protein to Rb protein was decreased and p27Kip1 expression was unchanged in comparison with SMCs cultured on plastic plates...
  59. Perry M, Baker J, Gibeon D, Adcock I, Chung K. Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. Am J Respir Cell Mol Biol. 2014;50:7-17 pubmed publisher
    ..by microRNA-221 and microRNA-222, through modulation of the cyclin-dependent kinase inhibitors, p21(WAF1) and p27(kip1)...
  60. Hsueh Y, Chen H, Wu S, Wang T, Chen J, Ma D. Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol Ther Methods Clin Dev. 2015;2:15014 pubmed publisher
    ..In B4G12 cells, enhanced cyclin D1 expression, reduced p27(KIP1)/p21(CIP1) levels, and the G1/S transition were detected upon transfection with YAP...
  61. Thewes V, Simon R, Hlevnjak M, Schlotter M, Schroeter P, Schmidt K, et al. The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer. Oncogene. 2017;36:4124-4134 pubmed publisher
    ..Mechanistically, BCAT1 indirectly controlled expression of the cell cycle inhibitor p27Kip1 thereby affecting pRB...
  62. Liu J, Zhao Y, Li W, Hou Y, Li T, Zhao Z, et al. Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
    ..we used yeast-two-hybrid screening to identify cytosolic Ca2+ and integrin-binding protein 1 (CIB1), as its interacting partner...
  63. Holtrich U, Wolf G, Yuan J, Bereiter Hahn J, Karn T, Weiler M, et al. Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. Oncogene. 2000;19:4832-9 pubmed
    ..Furthermore, Fnk binds to the Ca2+/integrin-binding protein Cib in two-hybrid-analyses and co-immunoprecipitation in assays...
  64. Sobczak A, Debowska K, Blazejczyk M, Kreutz M, Kuznicki J, Wojda U. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochim Biophys Acta. 2011;1813:1025-37 pubmed publisher
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium. ..
  65. Naik M, Naik U. Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. Int J Biochem Cell Biol. 2011;43:120-9 pubmed publisher
    ..Plk2 and Plk3, two members of this family, are known to interact with calcium- and integrin-binding protein 1 (CIB1). Activity of both Plk2 and Plk3 is inhibited by CIB1 in a calcium-dependent manner...
  66. Giese A, Tang Y, Sinha G, Bowl M, Goldring A, Parker A, et al. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nat Commun. 2017;8:43 pubmed publisher
    ..Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice. ..
  67. Wang X, Peng X, Zhang X, Xu H, Lu C, Liu L, et al. The Emerging Roles of CIB1 in Cancer. Cell Physiol Biochem. 2017;43:1413-1424 pubmed publisher
    Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis...
  68. Quejada J, Park S, Awari D, Shi F, Yamamoto H, Kawano F, et al. Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1. Nucleic Acids Res. 2017;45:e172 pubmed publisher
    ..Arabidopsis photoreceptor Flavin Kelch-repeat F-box 1 (FKF1) and its binding partner GIGANTEA (GI) as well as CRY2/CIB1. By combining the mutagenesis of FKF1 with the optimization of a split FKF1/GI dimerized Gal4-VP16 transcriptional ..
  69. Hallett S, Pastok M, Morgan R, Wittner A, Blundell K, Felletar I, et al. Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System. Cell Rep. 2017;21:1386-1398 pubmed publisher
    ..Overall, our data reveal multiple mechanisms whereby the Hsp90 system may control formation of CDK4- and CDK6-cyclin complexes under different cellular conditions. ..
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    ..of nine proteins were significantly higher than those of healthy controls, with calcium and integrin binding 1 (CIB1) protein showing the greatest significance (p = 0.002)...
  71. Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, et al. Cavin-2 in oral cancer: A potential predictor for tumor progression. Mol Carcinog. 2016;55:1037-47 pubmed publisher
    ..cell-cycle arrest at the G1 phase resulting from up-regulated cyclin-dependent kinase inhibitors (p21(Cip1) and p27(Kip1) ) and down-regulated cyclins (cyclin D1, cyclin E) and cyclin-dependent kinases (CDK2, CDK4, and CDK6)...
  72. Velaithan V, Okuda K, Ng M, Samat N, Leong S, Faudzi S, et al. Zebrafish phenotypic screen identifies novel Notch antagonists. Invest New Drugs. 2017;35:166-179 pubmed publisher
    ..proliferation and induced G0/G1 cell cycle arrest of ORL-150 cells through inducing p27KIP1...
  73. Ogawa M, Saitoh F, Sudou N, Sato F, Fujieda H. Cell type-specific effects of p27KIP1 loss on retinal development. Neural Dev. 2017;12:17 pubmed publisher
    ..p27KIP1 (p27), one of the major CDK inhibitors in the retina, has been shown to control the timing of cell cycle exit ..
  74. Fedele M, Paciello O, De Biase D, Monaco M, Chiappetta G, Vitiello M, et al. HMGA2 cooperates with either p27kip1 deficiency or Cdk4R24C mutation in pituitary tumorigenesis. Cell Cycle. 2017;:1-29 pubmed publisher
    ..Hmga2/T mice, overexpressing the truncated/active form of the Hmga2 gene, either with the knockout mice for p27kip1, or with the knockin mice for the Cdk4R24C mutation, both developing pituitary adenomas...
  75. Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K. Glucose deprivation induces primary cilium formation through mTORC1 inactivation. J Cell Sci. 2018;131: pubmed publisher
    ..In contrast, rapamycin treatment increased the level of the p27KIP1 (also known as CDKN1B) cyclin-dependent kinase inhibitor, and rapamycin-induced ciliogenesis was abrogated in ..
  76. Seki N, Hayashi A, Abe M, Araki R, Fujimori A, Fukumura R, et al. Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization. J Hum Genet. 1998;43:275-7 pubmed
    ..3-q26.1 region on chromosome 15. ..
  77. Henderson M, Russell A, Hird S, Munoz M, Clancy J, Lehrbach G, et al. EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem. 2002;277:26468-78 pubmed
    ..The data presented here demonstrate a role for EDD in PR signaling but also suggest a link to cancer through DNA damage response pathways. ..
  78. Bigaud E, Corrales F. Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease. Mol Cell Proteomics. 2016;15:1498-510 pubmed publisher
    ..play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27(kip1) The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP± mice...
  79. Pathak G, Spiltoir J, Höglund C, Polstein L, Heine Koskinen S, Gersbach C, et al. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res. 2017;45:e167 pubmed publisher
    ..In previous work, we used cryptochrome 2 (CRY2) and CIB1, Arabidopsis proteins that interact upon light illumination, to regulate transcription with light in yeast...
  80. Mi Y, Sun C, Wei B, Sun F, Guo Y, Hu Q, et al. Coatomer subunit beta 2 (COPB2), identified by label-free quantitative proteomics, regulates cell proliferation and apoptosis in human prostate carcinoma cells. Biochem Biophys Res Commun. 2018;495:473-480 pubmed publisher
    ..CDK2, CDK4, and cyclin D1 were downregulated, whereas p21 Waf1/Cip1 and p27 Kip1 were upregulated, affecting the cell cycle signaling pathway...
  81. Sanarico A, Ronchini C, Croce A, Memmi E, Cammarata U, De Antoni A, et al. The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemiaAG Sanarico et al. Leukemia. 2017;: pubmed publisher
    ..Mechanistically, WWP1 inactivation induces the accumulation of its protein substrate p27Kip1, which ultimately contributes to G0/G1 cell cycle arrest of AML blasts...
  82. Bernstein H, Blazejczyk M, Rudka T, Gundelfinger E, Dobrowolny H, Bogerts B, et al. The Alzheimer disease-related calcium-binding protein Calmyrin is present in human forebrain with an altered distribution in Alzheimer's as compared to normal ageing brains. Neuropathol Appl Neurobiol. 2005;31:314-24 pubmed
    The EF-hand calcium binding protein Calmyrin (also called CIB-1) was shown to interact with presenilin-2 (PS-2), suggesting that this interaction might play a role in the pathogenesis of Alzheimer's disease (AD)...
  83. Kumar B, Roy A, Veettil M, Chandran B. Insight into the Roles of E3 Ubiquitin Ligase c-Cbl, ESCRT Machinery, and Host Cell Signaling in Kaposi's Sarcoma-Associated Herpesvirus Entry and Trafficking. J Virol. 2018;92: pubmed publisher
    ..focal adhesion kinase [FAK], Src, phosphatidylinositol 3-kinase [PI3-K], and RhoA-GTPase), adaptors (c-Cbl, CIB1, Crk, p130Cas, and GEF-C3G), actin, and myosin II light chain that lead to virus entry via macropinocytosis...
  84. Becker W. A wake-up call to quiescent cancer cells: potential use of DYRK1B inhibitors in cancer therapy. FEBS J. 2017;: pubmed publisher
    ..Specifically, DYRK1B controls the S phase checkpoint by stabilizing the CDK inhibitor p27Kip1 and inducing the degradation of cyclin D...
  85. Sobczak A, Blazejczyk M, Piszczek G, Zhao G, Kuznicki J, Wojda U. Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form. Acta Biochim Pol. 2005;52:469-76 pubmed
    ..In summary, our data indicate that although calmyrin forms stable covalent dimers in vitro, it most probably functions as a monomer in vivo. ..
  86. Lanctot A, Guo Y, Le Y, Edens B, Nowakowski R, Feng Y. Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017;20:1148-1160 pubmed publisher
    ..Loss of Brap resulted in elevated Skp2, which increased p27Kip1 destruction, leading to G1 phase truncation and premature S phase entry...
  87. Lopez Sanchez E, Francés Muñoz E, Chaques V, Sanchez Benavent M, Menezo J. Optic nerve alterations in P27(Kip1) knockout mice. Eur J Ophthalmol. 2007;17:377-82 pubmed
    ..characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the P27(Kip1) gene, mainly involved in cell cycle arrest, apoptosis control, and retinoblastoma protein phosphorylation.
  88. Zhu S, Wang L, Cao Z, Wang J, Jing M, Xia Z, et al. Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B. Biochem Biophys Res Commun. 2016;471:95-102 pubmed publisher
    ..Our results showed that HCV infection induced expression of CYP4F12 protein, which bound to the HCV replication complex to facilitate viral replication. ..
  89. Kuppers D, Schmitt T, Hwang H, Samraj L, Clurman B, Fero M. The miR-106a~363Xpcl1 miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27Kip1 cell cycle inhibitor. Oncotarget. 2017;8:50680-50691 pubmed publisher
    ..Consistent with this, concurrent p27 Kip1 deletion dramatically accelerated lymphomagenesis, indicating that p27 is rate limiting for tumor ..
  90. Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, et al. G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Exp Cell Res. 2017;360:273-280 pubmed publisher
    ..05). Among these, 9 genes - AKT1, p16INK4, p27KIP1, p19INK4, IGFBP3, MAPK14, PLAU, THBS1, TP73 - were up-regulated, while 8 genes, Cyclin A2, Cyclin ..
  91. Pashkovskiy P, Soshinkova T, Korolkova D, Kartashov A, Zlobin I, Lyubimov V, et al. The effect of light quality on the pro-/antioxidant balance, activity of photosystem II, and expression of light-dependent genes in Eutrema salsugineum callus cells. Photosynth Res. 2018;136:199-214 pubmed publisher
    ..genes (POR B, C) involved in the biosynthesis of chlorophyll, and the key photoreceptor signalling genes (CIB1, CRY2, PhyB, PhyA, and PIF3) were determined...
  92. Michel V, Booth K, Patni P, Cortese M, Azaiez H, Bahloul A, et al. CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO Mol Med. 2017;9:1711-1731 pubmed publisher