CIAPIN1

Summary

Gene Symbol: CIAPIN1
Description: cytokine induced apoptosis inhibitor 1
Alias: Anamorsin, DRE2, PRO0915, anamorsin, fe-S cluster assembly protein DRE2 homolog
Species: human
Products:     CIAPIN1

Top Publications

  1. Shibayama H, Takai E, Matsumura I, Kouno M, Morii E, Kitamura Y, et al. Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis. J Exp Med. 2004;199:581-92 pubmed
    ..Using an expression cloning method, we identified a novel antiapoptotic molecule named Anamorsin, which does not show any homology to known apoptosis regulatory molecules such as Bcl-2 family, caspase family, ..
  2. Zhang Y, Lyver E, Nakamaru Ogiso E, Yoon H, Amutha B, Lee D, et al. Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis. Mol Cell Biol. 2008;28:5569-82 pubmed publisher
    ..The human Dre2 homolog (implicated in blocking apoptosis and called CIAPIN1 or anamorsin) was able to complement the nonviability of a Deltadre2 deletion strain...
  3. Hao Z, Li X, Qiao T, Du R, Hong L, Fan D. CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells. Cancer Biol Ther. 2006;5:261-6 pubmed
    In a previous study, we observed that cytokine-induced apoptosis inhibitor 1 (CIAPIN1), a newly identified apoptosis inhibitor, was upregulated at the mRNA level in a multidrug-resistant gastric cancer cell line SGC7901/VCR...
  4. Hao Z, Li X, Qiao T, Du R, Zhang G, Fan D. Subcellular localization of CIAPIN1. J Histochem Cytochem. 2006;54:1437-44 pubmed
    Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is a newly identified anti-apoptotic molecule...
  5. Li X, Hong L, Zhao Y, Jin H, Fan R, Du R, et al. A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. Biochem Cell Biol. 2007;85:741-50 pubmed
    We investigated the role of cytokine-induced apoptosis inhibitor 1 (CIAPIN1), a newly identified apoptosis inhibitor, in leukemia cell multidrug resistance (MDR) and its possible underlying mechanisms...
  6. Li X, Hao Z, Fan R, Zou X, Jin H, Pan Y, et al. CIAPIN1 inhibits gastric cancer cell proliferation and cell cycle progression by downregulating CyclinD1 and upregulating P27. Cancer Biol Ther. 2007;6:1539-45 pubmed
    b>CIAPIN1, a newly identified apoptosis-related molecule, was found to be downregulated in human gastric cancer tissues as compared to the matched adjacent nonneoplastic tissues...
  7. Li X, Pan Y, Fan R, Jin H, Han S, Liu J, et al. Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo. Carcinogenesis. 2008;29:1587-93 pubmed publisher
    ..Cytokine-induced antiapoptotic molecule (CIAPIN1), a recently reported antiapoptotic molecule which plays an essential role in mouse definitive hematopoiesis, is ..
  8. Saito Y, Shibayama H, Tanaka H, Tanimura A, Kanakura Y. A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK. Biochem Biophys Res Commun. 2011;405:303-7 pubmed publisher
    b>Anamorsin (AM) plays crucial roles in hematopoiesis and embryogenesis. AM deficient (AM KO) mice die during late gestation; AM KO embryos are anemic and very small compared to wild type (WT) embryos...
  9. He L, Wang H, Jin H, Guo C, Xie H, Yan K, et al. CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. Cancer Lett. 2009;276:88-94 pubmed publisher
    Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer...

More Information

Publications53

  1. Shizusawa T, Shibayama H, Murata S, Saitoh Y, Sugimoto Y, Matsumura I, et al. The expression of anamorsin in diffuse large B cell lymphoma: possible prognostic biomarker for low IPI patients. Leuk Lymphoma. 2008;49:113-21 pubmed publisher
    b>Anamorsin is a cell-death-defying factor, which was originally isolated as a molecule that conferred resistance to apoptosis induced by growth factor starvation...
  2. Yeo H, Shin M, Yeo E, Choi Y, Kim D, Kim D, et al. Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways. Free Radic Biol Med. 2019;135:68-78 pubmed publisher
    Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) protein is widely expressed in the brain and it is known that this protein is involved in cell survival including dopaminergic neuronal cells...
  3. Ferecatu I, Goncalves S, Golinelli Cohen M, Clemancey M, Martelli A, Riquier S, et al. The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1. J Biol Chem. 2014;289:28070-86 pubmed publisher
    ..protein anchored in the mitochondrial outer membrane, strictly depends on ISC machineries and not on the CIA or CIAPIN1. We identify a dedicated ISC/export pathway in which augmenter of liver regeneration, a mitochondrial Mia40-..
  4. Zheng J, Xu T, Chen F, Zhang Y. MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1. Pathol Oncol Res. 2019;: pubmed publisher
    ..bioinformatics and luciferase reporter assays demonstrated that cytokine-induced apoptosis inhibitor 1 (CIAPIN1), an anti-apoptotic molecule was a direct target of miR-195-5p in NSCLC cells...
  5. Lu D, Xiao Z, Wang W, Xu Y, Gao S, Deng L, et al. Down regulation of CIAPIN1 reverses multidrug resistance in human breast cancer cells by inhibiting MDR1. Molecules. 2012;17:7595-611 pubmed publisher
    Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), initially named anamorsin, a newly indentified antiapoptotic molecule is a downstream effector of the receptor tyrosine kinase-Ras signaling pathway...
  6. Zhang Y, Fang J, Ma H. Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1. Biochem Cell Biol. 2018;: pubmed publisher
    ..Importantly, bioinformatic analysis and dual-luciferase reporter assay revealed that CIAPIN1 was a direct functional target of miR-182-5p, and inhibition of miR-182-5p can lead to an increase of CIAPIN1 ..
  7. Buzas D, Nakamura M, Kinoshita T. Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2014;111:13565-70 pubmed publisher
    ..in maternal activation of FWA-GFP in the EDL, and isolated an allele of the yeast Dre2/human antiapoptotic factor CIAPIN1 homolog, encoding an enzyme previously implicated in the cytosolic Fe-S biogenesis pathway (CIA), which we named ..
  8. Lau Y, Santos B, Barbosa M, Pales Espinosa E, Allam B. Regulation of apoptosis-related genes during interactions between oyster hemocytes and the alveolate parasite Perkinsus marinus. Fish Shellfish Immunol. 2018;83:180-189 pubmed publisher
    ..Results indicate the involvement of the mitochondrial pathway (Bcl-2, anamorsin) of apoptosis in C. virginica exposed to P. marinus...
  9. Zhang Y, Yang C, Dancis A, Nakamaru Ogiso E. EPR studies of wild type and mutant Dre2 identify essential [2Fe--2S] and [4Fe--4S] clusters and their cysteine ligands. J Biochem. 2017;161:67-78 pubmed publisher
    Yeast Dre2 (anamorsin or CIAPIN1) is an essential component for cytosolic Fe/S cluster biosynthesis...
  10. Lyu L, Li X, Liu X, Su L, Li X, Fan D. [Expression of cytokine-induced apoptosis inhibitor 1 in gastric cancer tissues and its effects on invasion and migration of SGC-7901 cell]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015;18:941-5 pubmed
    To examine the expression of cytokine-induced apoptosis inhibitor1 (CIAPIN1) in gastric cancer and normal mucosa tissues, and to investigate its effects on migration and invasion of gastric cancer cells...
  11. Li H, Stümpfig M, Zhang C, An X, Stubbe J, Lill R, et al. The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements. J Biol Chem. 2017;292:11445-11451 pubmed publisher
    ..2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for ..
  12. Yamagishi J, Asada M, Hakimi H, Tanaka T, Sugimoto C, Kawazu S. Whole-genome assembly of Babesia ovata and comparative genomics between closely related pathogens. BMC Genomics. 2017;18:832 pubmed publisher
    ..An anamorsin homolog is one of them. The human anamorsin is involved in hematopoiesis and the homolog was present in B...
  13. Huang M, Facca C, Fatmi Z, Baïlle D, Bénakli S, Vernis L. DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo. Sci Rep. 2016;6:29361 pubmed publisher
    ..through up-regulation of two highly conserved genes controlling cytosolic Fe-S biosynthesis and oxidative stress, Dre2 and Tah18...
  14. Tang M, Liang Y, Chan J, Wong S, Chen E, Yao Y, et al. Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE. 2013;8:e59477 pubmed publisher
    ..In contrast, ten proteins (CIAPIN1, FAM50A, SUMO2 HSPB1 NSFL1C, PCBP2, YWHAG, STMN1, TPD52L2 and PDAP1) were found up-regulated...
  15. Yoshikawa Y, Nasuno R, Kawahara N, Nishimura A, Watanabe D, Takagi H. Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast. Nitric Oxide. 2016;57:85-91 pubmed publisher
    ..that the flavoprotein Tah18, which was previously shown to transfer electrons to the iron-sulfur cluster protein Dre2, is involved in NOS-like activity in the yeast Saccharomyces cerevisiae...
  16. Banci L, Ciofi Baffoni S, Gajda K, Muzzioli R, Peruzzini R, Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nat Chem Biol. 2015;11:772-8 pubmed publisher
    ..a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved ..
  17. Banci L, Camponeschi F, Ciofi Baffoni S, Muzzioli R. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. J Am Chem Soc. 2015;137:16133-43 pubmed publisher
    ..of apo BOLA2 with the apo and holo states of GRX3 and studied the role of BOLA2 in the GRX3-dependent anamorsin maturation pathway...
  18. Wang J, Li Q, Wang C, Xiong Q, Lin Y, Sun Q, et al. Knock-down of CIAPIN1 sensitizes K562 chronic myeloid leukemia cells to Imatinib by regulation of cell cycle and apoptosis-associated members via NF-κB and ERK5 signaling pathway. Biochem Pharmacol. 2016;99:132-45 pubmed publisher
    b>CIAPIN1 (cytokine-induced apoptosis inhibitor 1) was recently identified as an essential downstream effector of the Ras signaling pathway...
  19. Li B, Li Q, Lin Y, Jin W, Pang T. [Expression of CIAPIN1 gene in BMMNC of patients with leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:570-3 pubmed
    This study was aimed to investigate the expression level of CIAPIN1 mRNA in leukemia patients and explore its significance in leukemias...
  20. Banci L, Bertini I, Ciofi Baffoni S, Boscaro F, Chatzi A, Mikolajczyk M, et al. Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery. Chem Biol. 2011;18:794-804 pubmed publisher
    Human anamorsin was implicated in cytosolic iron-sulfur (Fe/S) protein biogenesis...
  21. Banci L, Ciofi Baffoni S, Mikolajczyk M, Winkelmann J, Bill E, Pandelia M. Human anamorsin binds [2Fe-2S] clusters with unique electronic properties. J Biol Inorg Chem. 2013;18:883-93 pubmed publisher
    The eukaryotic anamorsin protein family, which has recently been proposed to be part of an electron transfer chain functioning in the early steps of cytosolic iron-sulfur (Fe/S) protein biogenesis, is characterized by a largely ..
  22. Wang X, Gao S, Guo X, Sun W, Yan Z, Wang W, et al. CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo. Braz J Med Biol Res. 2014;47:273-8 pubmed
    Overexpression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) contributes to multidrug resistance (MDR) in breast cancer...
  23. Yang Z, Wang W, Zhang Q. CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Curr Neurovasc Res. 2013;10:4-10 pubmed
    ..Cytokine induced apoptosis inhibitor (CIAPIN1) is a novel antiapoptotic molecule and plays a vitally important role in malignant phenotypes of cancers...
  24. Wang J, Xu H, Zhang H, Wang Q, Wang C, Zhang H, et al. CIAPIN1 targets Na+/H+ exchanger 1 to mediate K562 chronic myeloid leukemia cells' differentiation via ERK1/2 signaling pathway. Leuk Res. 2014;38:1117-25 pubmed publisher
    b>CIAPIN1 (cytokine-induced antiapoptotic inhibitor 1) was recently identified as an essential downstream effector of the Ras signaling pathway. However, its potential role in regulating myeloid differentiation remains unclear...
  25. Hao Z, Li X, Qiao T, Fan D. Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity. Int J Biol Macromol. 2008;42:27-32 pubmed
    b>CIAPIN1 is a newly identified anti-apoptosis molecule which plays an important role in definitive haematopoiesis in mouse fetal liver and confers multidrug resistance in gastric cancer cells...
  26. Nymoen D, Holth A, Hetland Falkenthal T, Trope C, Davidson B. CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma. Mol Cancer. 2015;14:44 pubmed publisher
    ..effusions (n = 150) were analyzed for mRNA expression of AKR1C1, ABCA4, ABCA13, ABCB10, BIRC6, CASP9, CIAPIN1, FAS, MGMT, MUTYH, POLH, SRC, TBRKB and XPA using quantitative real-time PCR...
  27. Yu S, Yeo H, Choi S, Kim S. Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways. Int J Biochem Cell Biol. 2016;80:10-18 pubmed publisher
    Cytokine-induced apoptosis inhibitor-1 (CIAPIN-1, formally named anamorsin) is a well-known regulator of apoptosis in many different cell types...
  28. Wang X, Pan J, Li J. Cytokine-induced apoptosis inhibitor 1 inhibits the growth and proliferation of multiple myeloma. Mol Med Rep. 2015;12:2056-62 pubmed publisher
    The present study investigated the differential expression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) in human multiple myeloma (MM) bone marrow tissue and adjacent healthy bone marrow tissue...
  29. Chen X, Li X, Chen J, Zheng P, Huang S, Ouyang X. Overexpression of CIAPIN1 inhibited pancreatic cancer cell proliferation and was associated with good prognosis in pancreatic cancer. Cancer Gene Ther. 2012;19:538-44 pubmed publisher
    Cytokine-induced antiapoptotic molecule (CIAPIN1), a newly identified apoptosis inhibitor, has been found to participate in the process of proliferation and tumorigenicity for several cancers...
  30. Netz D, Genau H, Weiler B, Bill E, Pierik A, Lill R. The conserved protein Dre2 uses essential [2Fe-2S] and [4Fe-4S] clusters for its function in cytosolic iron-sulfur protein assembly. Biochem J. 2016;473:2073-85 pubmed publisher
    ..Maturation is initiated by the electron transfer chain NADPH-diflavin reductase Tah18-Fe-S protein Dre2 that facilitates the de novo assembly of a [4Fe-4S] cluster on the scaffold complex Cfd1-Nbp35...
  31. Wang J, Xu H, Wang Q, Zhang H, Lin Y, Zhang H, et al. CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway. Exp Cell Res. 2015;333:60-72 pubmed publisher
    Cytokine-induced antiapoptotic inhibitor 1 (CIAPIN1) was recently identified as an essential downstream effector of the Ras signaling pathway and has been confirmed to be closely associated with various malignant tumors...
  32. Zheng X, Zhao Y, Wang X, Li Y, Wang R, Jiang Y, et al. Decreased expression of CIAPIN1 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma. Dig Dis Sci. 2010;55:3408-14 pubmed publisher
    b>CIAPIN1, a newly identified antiapoptotic molecule, is a downstream effector of the receptor tyrosine kinase-Ras signaling pathway in the mouse Ba/F3 pro-B cell line...
  33. Shi H, Zhou Y, Liu H, Chen C, Li S, Li N, et al. Expression of CIAPIN1 in human colorectal cancer and its correlation with prognosis. BMC Cancer. 2010;10:477 pubmed publisher
    The cytokine-induced anti-apoptotic molecule (CIAPIN1) had been found to be a differentially-expressed gene involved in a variety of cancers, and it was also considered as a candidate tumour suppressor gene in gastric cancer, renal ..
  34. Vieira D, Emiliani G, Bartolini P, Podda A, Centritto M, Luro F, et al. A L-type lectin gene is involved in the response to hormonal treatment and water deficit in Volkamer lemon. J Plant Physiol. 2017;218:94-99 pubmed publisher
    ..sinensis and the in silico study of the 5'UTR region showed the presence of cis-responsive elements to SA, DRE2 and ABA...
  35. Huang Z, Su G, Hu W, Bi X, Zhang L, Wan G. The study on expression of CIAPIN1 interfering hepatocellular carcinoma cell proliferation and its mechanisms. Eur Rev Med Pharmacol Sci. 2017;21:3054-3060 pubmed
    ..This study was designed to investigate the effect of the cytokine-induced apoptosis inhibitor 1 (CIAPIN1) on hepatocellular carcinoma cell proliferation and invasion...
  36. Vernis L, Facca C, Delagoutte E, Soler N, Chanet R, Guiard B, et al. A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. PLoS ONE. 2009;4:e4376 pubmed publisher
    ..Dre2, an essential Fe/S cluster protein and homologue of human anti-apoptotic Ciapin1, was identified as a molecular partner of Tah18 in the absence of stress...
  37. Yun N, Lee Y, Kim C, Shibayama H, Tanimura A, Hamanaka Y, et al. Anamorsin, a novel caspase-3 substrate in neurodegeneration. J Biol Chem. 2014;289:22183-95 pubmed publisher
    ..substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis...
  38. Banci L, Bertini I, Calderone V, Ciofi Baffoni S, Giachetti A, Jaiswal D, et al. Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis. Proc Natl Acad Sci U S A. 2013;110:7136-41 pubmed publisher
    ..protein assembly machinery, two human key proteins--NADPH-dependent diflavin oxidoreductase 1 (Ndor1) and anamorsin--form a stable complex in vivo that was proposed to provide electrons for assembling cytosolic iron-sulfur ..
  39. Li X, Fan R, Zou X, Hong L, Gao L, Jin H, et al. [Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA]. Mol Biol (Mosk). 2008;42:102-9 pubmed
    The overexpression of a new cytokine-induced apoptosis inhibitor 1 (CIAPIN1) gene has been shown previously to promote a multidrug resistant phenotype in gastric cancer cells through the upregulation of MDR1 and MRP1...
  40. Frey A, Palenchar D, Wildemann J, Philpott C. A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery. J Biol Chem. 2016;291:22344-22356 pubmed publisher
    ..Fe-S coordination by Glrx3·BolA2 did not depend on Ciapin1 or Ciao1, proteins that bind Glrx3 and are involved in cytosolic Fe-S cluster assembly and distribution...
  41. Netz D, Stümpfig M, Dore C, Muhlenhoff U, Pierik A, Lill R. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010;6:758-65 pubmed publisher
    ..The pathway is conserved in eukaryotes, as human Ndor1-Ciapin1 proteins can functionally replace yeast Tah18-Dre2.
  42. Cai X, Wang J, Xin X. CIAPIN1 nuclear accumulation predicts poor clinical outcome in epithelial ovarian cancer. World J Surg Oncol. 2012;10:112 pubmed publisher
    ..The expression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) correlates with the malignant progression of several cancers...
  43. Bastow E, Bych K, Crack J, Le Brun N, Balk J. NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulphur proteins in Arabidopsis thaliana. Plant J. 2017;89:590-600 pubmed publisher
    ..To find protein interaction partners of NBP35, a yeast-two-hybrid screen was carried out that identified NBP35 and DRE2 (Derepressed for Ribosomal protein S14 Expression)...
  44. Song G, Cheng C, Li Y, Shaw N, Xiao Z, Liu Z. Crystal structure of the N-terminal methyltransferase-like domain of anamorsin. Proteins. 2014;82:1066-71 pubmed publisher
    b>Anamorsin is a recently identified molecule that inhibits apoptosis during hematopoiesis. It contains an N-terminal methyltransferase-like domain and a C-terminal Fe-S cluster motif. Not much is known about the function of the protein...