chromogranin A

Summary

Gene Symbol: chromogranin A
Description: chromogranin A
Alias: CGA, chromogranin-A, SP-I, betagranin (N-terminal fragment of chromogranin A), catestatin, chromofungin, parathyroid secretory protein 1, pituitary secretory protein I
Species: human
Products:     chromogranin A

Top Publications

  1. Curry W, Shaw C, Johnston C, Thim L, Buchanan K. Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour. FEBS Lett. 1992;301:319-21 pubmed
    The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour...
  2. Strub J, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, et al. Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. J Biol Chem. 1996;271:28533-40 pubmed
    ..Here, we characterize a large natural fragment, corresponding to chromogranin A 79-431, that inhibits growth of both Gram-positive and Gram-negative bacteria...
  3. Jiang Q, Taupenot L, Mahata S, Mahata M, O Connor D, Miles L, et al. Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release. J Biol Chem. 2001;276:25022-9 pubmed
    b>Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for ..
  4. Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Mol Biol Cell. 2002;13:3388-99 pubmed
    b>Chromogranin A (CgA) is transported restrictedly to secretory granules in neuroendocrine cells. In addition to pH- and Ca(2+)-dependent aggregation, CgA is known to bind to a number of vesicle matrix proteins...
  5. Montero Hadjadje M, Vaudry H, Turquier V, Leprince J, Do Rego J, Yon L, et al. Localization and characterization of evolutionarily conserved chromogranin A-derived peptides in the rat and human pituitary and adrenal glands. Cell Tissue Res. 2002;310:223-36 pubmed
    b>Chromogranin A (CgA) is a neuroendocrine protein that undergoes proteolytic cleavage in secretory granules...
  6. Ferrero E, Scabini S, Magni E, Foglieni C, Belloni D, Colombo B, et al. Chromogranin A protects vessels against tumor necrosis factor alpha-induced vascular leakage. FASEB J. 2004;18:554-6 pubmed
    Elevated levels of circulating chromogranin A (CgA), a protein stored in the secretory granules of many neuroendocrine cells and neurons, have been detected in the blood of patients with neuroendocrine tumors or heart failure...
  7. Mahapatra N, O Connor D, Vaingankar S, Hikim A, Mahata M, Ray S, et al. Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005;115:1942-52 pubmed
    The secretory prohormone chromogranin A (CHGA) is overexpressed in essential hypertension, a complex trait with genetic predisposition, while its catecholamine release-inhibitory fragment catestatin is diminished, and low catestatin ..
  8. Biswas N, Vaingankar S, Mahata M, Das M, Gayen J, Taupenot L, et al. Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin. Endocrinology. 2008;149:749-57 pubmed
    The plasma level of chromogranin A (CgA) is elevated in genetic hypertension...
  9. Salem R, Cadman P, Chen Y, Rao F, Wen G, Hamilton B, et al. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008;19:600-14 pubmed publisher
    b>Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells...

More Information

Publications104 found, 100 shown here

  1. Sciarra A, Di Silverio F, Autran A, Salciccia S, Gentilucci A, Alfarone A, et al. Distribution of high chromogranin A serum levels in patients with nonmetastatic and metastatic prostate adenocarcinoma. Urol Int. 2009;82:147-51 pubmed publisher
    We analyzed the incidence of elevated serum levels of chromogranin A (CgA) (as marker of neuroendocrine activity) in nonmetastatic and metastatic prostate cancer populations...
  2. Vaingankar S, Li Y, Biswas N, Gayen J, Choksi S, Rao F, et al. Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses. J Hypertens. 2010;28:817-25 pubmed publisher
    The phenotype of the chromogranin A (Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats display elevated CHGA expression...
  3. Lawrence B, Gustafsson B, Kidd M, Pavel M, Svejda B, Modlin I. The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am. 2011;40:111-34, viii pubmed publisher
    b>Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs)...
  4. Konecki D, Benedum U, Gerdes H, Huttner W. The primary structure of human chromogranin A and pancreastatin. J Biol Chem. 1987;262:17026-30 pubmed
    A full-length clone encoding human chromogranin A has been isolated from a lambda gt10 cDNA library of a human pheochromocytoma...
  5. Wen G, Mahata S, Cadman P, Mahata M, Ghosh S, Mahapatra N, et al. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004;74:197-207 pubmed
    ..b>Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (..
  6. Leibovitch I, Pinthus Y, Sella B, Ramon J. [Plasma chromogranin-A (CgA)--a potential marker for diagnosis, monitoring and management of prostate cancer patients]. Harefuah. 2006;145:25-9, 78 pubmed
    ..Circulating CgA levels were shown to reflect neuroendocrine differentiation and were found to correlate with the stage and the ..
  7. Lillie E, Mahata M, Khandrika S, Rao F, Bundey R, Wen G, et al. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. Circulation. 2007;115:2282-91 pubmed
    ..b>Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature...
  8. Malaguarnera M, Cristaldi E, Cammalleri L, Colonna V, Lipari H, Capici A, et al. Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer. Arch Gerontol Geriatr. 2009;48:213-7 pubmed publisher
    ..This study aimed at evaluating the clinical usefulness of CgA as a neuroendocrine (NE) serum-marker...
  9. Chen Y, Rao F, Rodriguez Flores J, Mahapatra N, Mahata M, Wen G, et al. Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure. Kidney Int. 2008;74:115-25 pubmed publisher
    b>Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons...
  10. Chen Y, Rao F, Rodriguez Flores J, Mahata M, Fung M, Stridsberg M, et al. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008;52:1468-81 pubmed publisher
    We aimed to determine whether the common variation at the chromogranin A (CHGA) locus increases susceptibility to hypertension. CHGA regulates catecholamine storage and release...
  11. Sciola V, Massironi S, Conte D, Caprioli F, Ferrero S, Ciafardini C, et al. Plasma chromogranin a in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:867-71 pubmed publisher
    Circulating chromogranin A (CgA) levels, a marker for neuroendocrine tumors including carcinoids, have recently been found elevated in some patients with inflammatory bowel disease (IBD), although their significance is unclear...
  12. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung M, et al. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009;20:1623-32 pubmed publisher
    b>Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells...
  13. Berruti A, Bollito E, Cracco C, Volante M, Ciccone G, Porpiglia F, et al. The prognostic role of immunohistochemical chromogranin a expression in prostate cancer patients is significantly modified by androgen-deprivation therapy. Prostate. 2010;70:718-26 pubmed publisher
    ..This study was undertaken to assess the prognostic role of tissue chromogranin A (CgA) expression in patients addressed to ADT as opposed to those who did not...
  14. Yao J, Pavel M, Phan A, Kulke M, Hoosen S, St Peter J, et al. Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus. J Clin Endocrinol Metab. 2011;96:3741-9 pubmed publisher
    ..b>Chromogranin A (CgA) and neuron-specific enolase (NSE) are considered general biomarkers of these tumors...
  15. Chou W, Hung Y, Hsu J, Chen J, Lu C, Hwang T, et al. Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients. Neuroendocrinology. 2012;95:344-50 pubmed publisher
    To evaluate the significance of plasma chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) in terms of disease status and treatment responses.
  16. Biondi A, Malaguarnera G, Vacante M, Berretta M, D Agata V, Malaguarnera M, et al. Elevated serum levels of Chromogranin A in hepatocellular carcinoma. BMC Surg. 2012;12 Suppl 1:S7 pubmed publisher
    ..has been observed in some tumor cells within some hepatocellular carcinoma nodules and elevated serum chromogranin A also been reported in patients with hepatocellular carcinoma...
  17. Helle K, Metz Boutigue M, Cerra M, Angelone T. Chromogranins: from discovery to current times. Pflugers Arch. 2018;470:143-154 pubmed publisher
    ..In the mid-1960s, the enzymatically inactive, major core protein, chromogranin A was shown to be exocytotically discharged from the stimulated adrenal gland in parallel with the co-stored ..
  18. Benyamin B, Maihofer A, Schork A, Hamilton B, Rao F, Schmid Schonbein G, et al. Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 2017;26:233-242 pubmed publisher
    ..genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptide derived from chromogranin A (CHGA), and other CHGA- or chromogranin B (CHGB)-related peptides, in 545?US and 1252 Australian subjects...
  19. Pereda D, Pardo M, Morales Y, Domínguez N, Arnau M, Borges R. Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour. Behav Brain Res. 2015;278:98-106 pubmed publisher
    ..We have used three different genetic mutant models of mice lacking chromogranin A, chromogranin B and both all on the same C57BL/6J background, to characterize the physiological roles of these ..
  20. Akila P, Vennila L. Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: An in vivo study. Biomed Pharmacother. 2016;84:208-214 pubmed publisher
    Intent of the present study has been made to appraise the cardioprotective effect of chlorogenic acid (CGA) on isoproterenol (ISO) induced myocardial infarction (MI) in male albino Wistar rats...
  21. Saito T, Tsuta K, Fukumoto K, Matsui H, Konobu T, Torii Y, et al. Combined small cell lung carcinoma and giant cell carcinoma: a case report. Surg Case Rep. 2017;3:52 pubmed publisher
    ..neuroendocrine differentiation, as indicated by positivity for synaptophysin and CD56 and negativity for chromogranin A. While the small cell component was E-cadherin-positive and vimentin-negative, the giant cell component was E-..
  22. Ye H, Li Z, Zheng Y, Chen Y, Zhou Z, Jin J. The attenuation of chlorogenic acid on oxidative stress for renal injury in streptozotocin-induced diabetic nephropathy rats. Arch Pharm Res. 2016;39:989-97 pubmed publisher
    The present study was undertaken to investigate whether chlorogenic acid (CGA) could protect kidney function against oxidative stress in the diabetic nephropathy (DN) rats...
  23. Kobayashi H, Kikuta K, Sekita T, Susa M, Nishimoto K, Sasaki A, et al. Diagnosis of extraskeletal myxoid chondrosarcoma in the thigh using EWSR1-NR4A3 gene fusion: a case report. J Med Case Rep. 2016;10:321 pubmed
    ..Immunohistochemistry revealed that the tumor was positive for S-100 and negative for synaptophysin, chromogranin A, and pan keratin (AE1/AE3). The percentage of Ki-67 was 10 % in the hot spot area...
  24. Chen Y, Rao F, Wen G, Gayen J, Zhang K, Vaingankar S, et al. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010;30:1395-400 pubmed publisher
    b>Chromogranin A (CHGA) plays a fundamental role in the biogenesis of catecholamine secretory granules...
  25. Romano R, Carter J, Folpe A. Aberrant intermediate filament and synaptophysin expression is a frequent event in malignant melanoma: an immunohistochemical study of 73 cases. Mod Pathol. 2015;28:1033-42 pubmed publisher
    ..and AE1/AE3 antibodies), desmin, neurofilament protein, glial fibrillary acidic protein, synaptophysin, and chromogranin A. Not all cases could be tested for all markers...
  26. Kang J, Kim Y, Chang J, Kho H. Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome. Arch Oral Biol. 2017;78:58-64 pubmed publisher
    ..The levels of cortisol, dehydroepiandrosterone (DHEA), 17β-estradiol, progesterone, chromogranin A, and blood contamination were determined from unstimulated whole saliva (UWS) and stimulated whole saliva (SWS)..
  27. Walter T, Tougeron D, Baudin E, Le Malicot K, Lecomte T, Malka D, et al. Poorly differentiated gastro-entero-pancreatic neuroendocrine carcinomas: Are they really heterogeneous? Insights from the FFCD-GTE national cohort. Eur J Cancer. 2017;79:158-165 pubmed publisher
    ..5), metastatic disease (HR = 1.6), NSE>2 upper limit of normal [ULN]; HR = 3.2), CgA>2 ULN (HR = 1.7) and lactate dehydrogenase >2 ULN (HR = 2.1)...
  28. Ohkawara T, Takeda H, Nishihira J. Protective effect of chlorogenic acid on the inflammatory damage of pancreas and lung in mice with l-arginine-induced pancreatitis. Life Sci. 2017;190:91-96 pubmed publisher
    ..Chlorogenic acid (CGA) is one of the polyphenols, and is known to have an anti-inflammatory effect...
  29. Hendy G, Bevan S, Mattei M, Mouland A. Chromogranin A. Clin Invest Med. 1995;18:47-65 pubmed
    b>Chromogranin A (CgA) is the major member of the granin family of acidic secretory glycoproteins that are expressed in all endocrine and neuroendocrine cells. Granins have been proposed to play multiple roles in the secretory process...
  30. Inoue R, Aoki M, Matsumoto Y, Haraoka S, Kazekawa K, Nabeshima K. Prolactin-producing pituitary adenoma with atypical spindle cell morphology: a case report. World J Surg Oncol. 2015;13:229 pubmed publisher
  31. Ward N, Hodgson J, Woodman R, Zimmermann D, Poquet L, Lévèques A, et al. Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. Food Funct. 2016;7:2197-203 pubmed publisher
    Coffee is a rich source of polyphenols, primarily chlorogenic acids (CGA). Certain polyphenols and polyphenol-rich foods and beverages have been shown to improve endothelial function and lower blood pressure (BP)...
  32. Fairweather M, Swanson R, Wang J, Brais L, Dutton T, Kulke M, et al. Management of Neuroendocrine Tumor Liver Metastases: Long-Term Outcomes and Prognostic Factors from a Large Prospective Database. Ann Surg Oncol. 2017;24:2319-2325 pubmed publisher
    ..3, p < 0.001), alkaline phosphatase within normal limit (WNL) (HR 0.4, p < 0.001), and chromogranin A WNL (HR 0.5, p < 0.001) were significant independent prognosticators for OS...
  33. Chen L, Zhang Y, Lin Y, Deng L, Feng S, Chen M, et al. The role of elevated serum procalcitonin in neuroendocrine neoplasms of digestive system. Clin Biochem. 2017;: pubmed publisher
    ..Serum PCT and serum CgA level were measured in 155 patients with NENs from digestive system...
  34. Zhai H, Ma X, Nie W, Li H, Peng C, Li X, et al. Paraganglioma of the Urinary Bladder: A Series of 22 Cases in a Single Center. Clin Genitourin Cancer. 2017;15:e765-e771 pubmed publisher
    ..Most PUB samples were positive for immunohistochemical (IHC) staining markers such as chromogranin A (CgA), Synaptophysin (Syn), CD56, and S-100 protein, while negative for IHC markers such as cytokeratins (CKs) ..
  35. Dai L, Kausar S, Abbas M, Wang T. Complete sequence and characterization of the Ectropis oblique mitochondrial genome and its phylogenetic implications. Int J Biol Macromol. 2018;107:1142-1150 pubmed publisher
    ..180. Twelve out of 13 PCGs initiated with canonical start codon (ATN), while cox1 started with CGA. The A+T rich element of E...
  36. Schrott Fischer A, Bitsche M, Humpel C, Walcher C, Maier H, Jellinger K, et al. Chromogranin peptides in amyotrophic lateral sclerosis. Regul Pept. 2009;152:13-21 pubmed publisher
    ..Eight cases of ALS and seven control cases were studied with semiquantitative immunocytochemistry for chromogranin A, chromogranin B and secretogranin II that are soluble constituents of large dense core vesicles, synaptophysin ..
  37. Khan M, Kirkwood A, Tsigani T, Lowe H, Goldstein R, Hartley J, et al. Early Changes in Circulating Tumor Cells Are Associated with Response and Survival Following Treatment of Metastatic Neuroendocrine Neoplasms. Clin Cancer Res. 2016;22:79-85 pubmed publisher
    ..Blood samples were obtained for evaluation of CTCs using the CellSearch platform and for chromogranin A (CgA) at baseline, three to five (median, 4.3) weeks and 10 to 15 (median 13.7) weeks after commencing therapy...
  38. Bianco M, Gasparri A, Generoso L, Assi E, Colombo B, Scarfo L, et al. Inhibition of chronic lymphocytic leukemia progression by full-length chromogranin A and its N-terminal fragment in mouse models. Oncotarget. 2016;7:41725-41736 pubmed publisher
    ..We observed that circulating chromogranin A (CgA) and its N-terminal fragment (called vasostatin-1, CgA1-76), two neuroendocrine secretory polypeptides ..
  39. Manta R, Nardi E, Pagano N, Ricci C, Sica M, Castellani D, et al. Pre-operative Diagnosis of Pancreatic Neuroendocrine Tumors with Endoscopic Ultrasonography and Computed Tomography in a Large Series. J Gastrointestin Liver Dis. 2016;25:317-21 pubmed publisher
    ..The final histological diagnosis was achieved on a post-surgical specimen. Chromogranin A (CgA) levels were measured. A total of 80 patients (mean age: 58 +/- 14.2 years; males: 42) were enrolled...
  40. Nishizawa Y, Hata T, Takemasa I, Yamasaki M, Akasaka H, Sugimoto K, et al. Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients. Surg Endosc. 2018;32:1434-1440 pubmed publisher
    ..Of these patients, 110 were evaluated using the comprehensive geriatric assessment (CGA) before surgery and were classified into lower or higher risk groups based on their scores...
  41. Gronewold J, Dahlmann C, Jager M, Hermann D. Identification of hospitalized elderly patients at risk for adverse in-hospital outcomes in a university orthopedics and trauma surgery environment. PLoS ONE. 2017;12:e0187801 pubmed publisher
    ..Geriatric risk screening followed by comprehensive geriatric assessment (CGA) and treatment has been requested by geriatric societies and task forces to identify patients at risk...
  42. Kwon M, Kim S, Roh J, Lee S, Kim S, Choi S, et al. An Introduction to a Head and Neck Cancer-Specific Frailty Index and Its Clinical Implications in Elderly Patients: A Prospective Observational Study Focusing on Respiratory and Swallowing Functions. Oncologist. 2016;21:1091-8 pubmed publisher
    ..Pretreatment functional evaluations were performed according to all comprehensive geriatric assessment (CGA) domains...
  43. Herburger K, Ryan L, Popper Z, Holzinger A. Localisation and substrate specificities of transglycanases in charophyte algae relate to development and morphology. J Cell Sci. 2018;131: pubmed publisher
    Cell wall-modifying enzymes have been previously investigated in charophyte green algae (CGA) in cultures of uniform age, giving limited insight into their roles...
  44. Inzani F, Petrone G, Fadda G, Rindi G. Cyto-histology in NET: what is necessary today and what is the future?. Rev Endocr Metab Disord. 2017;18:381-391 pubmed publisher
    ..neuroendocrine signature by immunohistochemistry is mandatory for the diagnosis; a minimum panel comprising chromogranin A and synaptophysin is recommended in the digestive system...
  45. Lv Y, Han X, Zhang C, Fang Y, Pu N, Ji Y, et al. Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs. Endocr Connect. 2018;7:169-178 pubmed publisher
    b>Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied...
  46. Yoto A, Fukui N, Kaneda C, Torita S, Goto K, Nanjo F, et al. Black tea aroma inhibited increase of salivary chromogranin-A after arithmetic tasks. J Physiol Anthropol. 2018;37:3 pubmed publisher
    ..aromas on physical and psychological stress induced by the Uchida-Kraepelin test, based on salivary chromogranin-A (CgA) levels as a stress marker and subjective evaluations (Profile of Mood States)...
  47. Yokom D, Alibhai S, Sattar S, Krzyzanowska M, Puts M. Geriatric oncology screening tools for CGA-based interventions: results from a phase II study of geriatric assessment and management for older adults with cancer. J Geriatr Oncol. 2018;: pubmed publisher
    ..studied for their ability to identify patients who have abnormal domains on a comprehensive geriatric assessment (CGA)...
  48. Murray S, Deaven L, Burton D, O Connor D, Mellon P, Deftos L. The gene for human chromogranin A (CgA) is located on chromosome 14. Biochem Biophys Res Commun. 1987;142:141-6 pubmed
    b>Chromogranin A (CgA) is a protein that is present in most neuroendocrine tissues and is co-secreted with their resident hormones...
  49. Gallo M, Levi R, Ramella R, Brero A, Boero O, Tota B, et al. Endothelium-derived nitric oxide mediates the antiadrenergic effect of human vasostatin-1 in rat ventricular myocardium. Am J Physiol Heart Circ Physiol. 2007;292:H2906-12 pubmed
    Vasostatins (VSs) are vasoactive peptides derived from chromogranin A (CgA), a protein contained in secretory granules of chromaffin and other cells...
  50. Mergler S, Skrzypski M, Sassek M, Pietrzak P, Pucci C, Wiedenmann B, et al. Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells. Cell Signal. 2012;24:233-46 pubmed publisher
    ..Here, we studied the expression and the role of TRPV1 in regulating intracellular Ca(2+) and chromogranin A (CgA) secretion in pancreatic NET BON-1 cell line and in primary NET cells (prNET)...
  51. El Salhy M, Gundersen D, Hatlebakk J, Hausken T. Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. Dig Dis Sci. 2012;57:3154-9 pubmed publisher
    ..In a previous study on IBS, some patients showed extremely high colonic chromogranin A cell density. Further examination of these patients showed that they suffered from LC...
  52. Mokhtar Pour A, Masir N, Isa M. Obstructive jaundice in small cell lung carcinoma. Malays J Pathol. 2015;37:149-52 pubmed
    ..A lung biopsy was done and histopathology reported a TTF- 1-positive, chromogranin A-positive, small cell carcinoma of the lung. On review, the pancreatic tumour was also TTF-1-positive...
  53. Miki M, Ito T, Hijioka M, Lee L, Yasunaga K, Ueda K, et al. Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors. Jpn J Clin Oncol. 2017;47:520-528 pubmed publisher
    Currently, serum chromogranin A is a well-established biomarker for pancreatic neuroendocrine tumors; however, other pancreatic diseases, oral use of a proton pump inhibitor and renal impairment can affect chromogranin A...
  54. Ali N, Rashid S, Nafees S, Hasan S, Shahid A, Majed F, et al. Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chem Biol Interact. 2017;272:80-91 pubmed publisher
    ..Chlorogenic acid (CGA) is one of the most abundant naturally occurring polyphenols in the human diet...
  55. Yildirim S, Bakkal M, Bulut H, Selek S. Quantitative evaluation of dental anxiety indicators in the serum and saliva samples of children treated under general anesthesia. Clin Oral Investig. 2018;22:2373-2380 pubmed publisher
    ..Pre-treatment and post-treatment biochemical parameters, including cortisol, alpha-amylase, and chromogranin A levels, in saliva and serum samples were also evaluated...
  56. Sotomayor P, Godoy A, Smith G, Huss W. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate. 2009;69:401-10 pubmed publisher
    ..The majority of Oct4A expressing cells co-expressed chromogranin A, and a subset of Oct4A expressing cells co-expressed synaptophysin, both markers of neuroendocrine ..
  57. van Asch B, Blibech I, Pereira Castro I, Rei F, da Costa L. The mitochondrial genome of Prays oleae (Insecta: Lepidoptera: Praydidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2108-9 pubmed publisher
    ..g. an >80% A + T content, an apparent CGA start codon for COX1 and an ATAGA(T)n motif in the control region, which also contains several copies of a 163-164â..
  58. Pasquer A, Walter T, Hervieu V, Forestier J, Scoazec J, Lombard Bohas C, et al. Surgical Management of Small Bowel Neuroendocrine Tumors: Specific Requirements and Their Impact on Staging and Prognosis. Ann Surg Oncol. 2015;22 Suppl 3:S742-9 pubmed publisher
    ..In the multivariate analysis, high chromogranin A (CgA) levels and peritoneal carcinomatosis were significantly associated with shorter OS...
  59. Peczkowska M, Cwikla J, Kidd M, Lewczuk A, Kolasińska Ćwikła A, Nieć D, et al. The clinical utility of circulating neuroendocrine gene transcript analysis in well-differentiated paragangliomas and pheochromocytomas. Eur J Endocrinol. 2017;176:143-157 pubmed
    ..e.m.). Amines were measured by HPLC and chromogranin A by ELISA...
  60. Woliński K, Kaznowski J, Klimowicz A, Maciejewski A, Łapińska Cwojdzińska D, Gurgul E, et al. Diagnostic value of selected biochemical markers in the detection of recurrence of medullary thyroid cancer - comparison of calcitonin, procalcitonin, chromogranin A, and carcinoembryonic antigen. Endokrynol Pol. 2017;68:434-437 pubmed publisher
    ..the study was to compare the diagnostic value of four selected markers - calcitonin (Ct), procalcitonin (PCT), chromogranin A (CgA), and carcinoembryonic antigen (CEA)...
  61. Mahata S, Mahata M, Fung M, O Connor D. Reprint of: Catestatin: a multifunctional peptide from chromogranin A. Regul Pept. 2010;165:52-62 pubmed publisher
    In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA]???????: RSMRLSFRARGYGFRGPGLQL; human CHGA???????: SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine ..
  62. Liu L, Ding W, Li R, Ye X, Zhao J, Jiang J, et al. Plasma levels and diagnostic value of catestatin in patients with heart failure. Peptides. 2013;46:20-5 pubmed publisher
    b>Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF...
  63. Wolf M, Riedlinger I, Lehmann R, Häring H, Schleicher E, Peter A. Comparison of the automated KRYPTOR chromogranin A assay with the DAKO ELISA. Clin Lab. 2014;60:2103-6 pubmed
    Currently available assays for the widely used marker for neuroendocrine tumors chromogranin A have a weak comparability, involve manual work, and require batch processing of the samples...
  64. Kaiserova M, Přikrylová Vranová H, Galuszka J, Stejskal D, Menšíková K, Zapletalova J, et al. Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease. Clin Auton Res. 2015;25:339-42 pubmed publisher
    An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD)...
  65. Schmidt H, Boese S, Lampe K, Jordan K, Fiedler E, Müller Werdan U, et al. Trans sectoral care of geriatric cancer patients based on comprehensive geriatric assessment and patient-reported quality of life - Results of a multicenter study to develop and pilot test a patient-centered interdisciplinary care concept for geriatr. J Geriatr Oncol. 2017;8:262-270 pubmed publisher
    ..patients with cancer we developed an interdisciplinary care program based on comprehensive geriatric assessment (CGA) and patient-reported HRQOL comprising tailored supportive measures and telephone-based counseling during 6month ..
  66. Conroy S, Parker S. Acute geriatrics at the front door. Clin Med (Lond). 2017;17:350-353 pubmed publisher
    ..Comprehensive geriatric assessment (CGA) is an evidence-based approach to improving their outcomes, as well as improving service outcomes...
  67. Naveed M, Hejazi V, Abbas M, Kamboh A, Khan G, Shumzaid M, et al. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2018;97:67-74 pubmed publisher
    ..Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-..
  68. Dai L, Zhou X, Kausar S, Abbas M, Wu L, Zhou H. Mitochondrial genome of Diaphania indica(saunders) (Lepidoptera: Pyraloidea) and implications for its phylogeny. Int J Biol Macromol. 2018;108:981-989 pubmed publisher
    ..All of the 12 PCGs initiate with canonical start codon (ATN), except for coxI that initiate with CGA. The A+T rich element of D. indica is 467bp long and contains many features common to Pyraloidea insects...
  69. Kakita K, Tsubouchi H, Adachi M, Takehana S, Shimazu Y, Takeda M. Local subcutaneous injection of chlorogenic acid inhibits the nociceptive trigeminal spinal nucleus caudalis neurons in rats. Neurosci Res. 2018;134:49-55 pubmed publisher
    Acute administration of chlorogenic acid (CGA) in vitro was recently shown to modulate potassium channel conductance and acid-sensing ion channels (ASICs) in the primary sensory neurons; however, in vivo peripheral effects of CGA on the ..
  70. Savilov P. [Influence of partial hepatectomie on ammoniumdetoxications function of liver at chronic tetrachlorcarbon hepatitis]. Patol Fiziol Eksp Ter. 2017;61:61-6 pubmed
    ..Conclusions. The obtained results show that CGA on the background of chronic hepatitis increases the pathological impact of CCl4 on amniocentesis liver function.
  71. Strub J, Sorokine O, Van Dorsselaer A, Aunis D, Metz Boutigue M. Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. J Biol Chem. 1997;272:11928-36 pubmed
    Bovine adrenal medullary chromogranin A, the major soluble component of chromaffin granules, is a phosphorylated glycoprotein...
  72. Rydning A, Lyng O, Adamsen B, Falkmer S, Sandvik A, Grønbech J. Mast cells are involved in the gastric hyperemic response to acid back diffusion via release of histamine. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1061-9 pubmed
    ..Mucosal mast cells (MMC), submucosal connective tissue mast cells (CTMC), and chromogranin A-immunoreactive cells (CgA IR) were assessed morphometrically. After mucosal exposure to 1...
  73. Hu Y, Malone J, Fagan A, Townsend R, Holtzman D. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Mol Cell Proteomics. 2005;4:2000-9 pubmed
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders. ..
  74. Bozdogan O, Atasoy P, Bozdogan N, Erekul S, Batislam E, Yilmaz E, et al. BAG-1 expression in hyperplastic and neoplastic prostate tissue: is there any relationship with BCL-related proteins and androgen receptor status?. Tumori. 2005;91:539-45 pubmed
    ..function and distribution of BAG-1 protein in hyperplastic and neoplastic prostate tissue and establish the relationship between this protein and BCL-related proteins (BCL-2 and BAX), androgen receptor (AR) expression and chromogranin A.
  75. Cindolo L, Franco R, Cantile M, Schiavo G, Liguori G, Chiodini P, et al. NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension?. Eur Urol. 2007;52:1365-73 pubmed
  76. Kos Kudła B, Zemczak A, Foltyn W, Marek B, Strzelczyk J, Telega A, et al. Octreotide suppression test in diagnosing and predicting the outcome of therapy in patients with neuroendocrine tumors. Preliminary report. Endokrynol Pol. 2007;58:123-9 pubmed
    b>Chromogranin A (CgA) is a non-specific marker of neuroendocrine tumors (NET) and is important in monitoring the disease course and NET treatment...
  77. Bilek R, Safarik L, Ciprová V, Vlcek P, Lisa L. Chromogranin A, a member of neuroendocrine secretory proteins as a selective marker for laboratory diagnosis of pheochromocytoma. Physiol Res. 2008;57 Suppl 1:S171-9 pubmed
    The function of chromogranin A (CGA) is reviewed, and the radioimmunometric determination of plasma CGA was evaluated as a marker of pheochromocytoma using a comparison of pheochromocytoma patients immediately before surgery (group P, n=..
  78. Zhang D, Lavaux T, Voegeli A, Lavigne T, Castelain V, Meyer N, et al. Prognostic value of chromogranin A at admission in critically ill patients: a cohort study in a medical intensive care unit. Clin Chem. 2008;54:1497-503 pubmed publisher
    ..The acute response to stress causes the release of catecholamines from the adrenal medulla accompanied by chromogranin A (CGA)...
  79. Takatsuji K, Sugimoto Y, Ishizaki S, Ozaki Y, Matsuyama E, Yamaguchi Y. The effects of examination stress on salivary cortisol, immunoglobulin A, and chromogranin A in nursing students. Biomed Res. 2008;29:221-4 pubmed
    This study aimed to assess the effects of examination stress on salivary cortisol, immunoglobulin A (IgA), and chromogranin A (CgA) in nursing students...
  80. Hoq M, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. J Dermatol Sci. 2011;64:108-18 pubmed publisher
    ..b>Catestatin, a neuroendocrine peptide that affects human autonomic functions, has recently been detected in keratinocytes ..
  81. Rao F, Chiron S, Wei Z, Fung M, Chen Y, Wen G, et al. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012;25:29-40 pubmed publisher
    ..The cardiometabolic syndrome comprised of multiple correlated traits, but its origin is incompletely understood. Chromogranin A (CHGA) is required for formation of the catecholamine secretory pathway in sympathochromaffin cells...
  82. Qi S, Huang M, Teng H, Lu Y, Jiang M, Wang L, et al. Autoantibodies to chromogranin A are potential diagnostic biomarkers for non-small cell lung cancer. Tumour Biol. 2015;36:9979-85 pubmed publisher
    ..To test the immunogenicity of chromogranin A (ChgA) as a B cell autoantigen and to assess the potential applications of ChgA autoantibodies as novel ..
  83. Rajasekaran T, Tan T, Ong W, Koo K, Chan L, Poon D, et al. Comprehensive Geriatric Assessment (CGA) based risk factors for increased caregiver burden among elderly Asian patients with cancer. J Geriatr Oncol. 2016;7:211-8 pubmed publisher
    This study aims to identify Comprehensive Geriatric Assessment (CGA) based risk factors to help predict caregiver burden among elderly patients with cancer...
  84. Stefanello N, Schmatz R, Pereira L, Cardoso A, Passamonti S, Spanevello R, et al. Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of streptozotocin-induced diabetic rats. J Nutr Biochem. 2016;38:145-153 pubmed publisher
    We evaluated the effect of chlorogenic acid (CGA), caffeine (CA) and coffee (CF) on components of the purinergic system from the cerebral cortex and platelets of streptozotocin-induced diabetic rats...
  85. Komo T, Kohashi T, Nakashima A, Ohmori I, Hihara J, Mukaida H, et al. Mixed adenoneuroendocrine carcinoma of the distal bile duct: A case report. Int J Surg Case Rep. 2017;39:203-207 pubmed publisher
    ..The non-adenocarcinoma component stained positive for synaptophysin and chromogranin A. The Ki-67 labeling index was 37%...
  86. Tchaou M, Darre T, Folligan K, Sabi A, Sonhaye L, Boume A, et al. Primary Neuroendocrine Breast Carcinoma in a 13-Year-Old Girl: Ultrasonography and Pathology Findings. Case Rep Radiol. 2017;2017:7915806 pubmed publisher
    ..According to immunohistochemistry performed on paraffin blocks in France, infiltrating ductal carcinoma with a strong neuroendocrine component was confirmed by CD56, CD57, and chromogranin A markers.
  87. Espinosa I, De Leo A, D Angelo E, Rosa Rosa J, Corominas M, González A, et al. Dedifferentiated endometrial carcinomas with neuroendocrine features: a clinicopathologic, immunohistochemical, and molecular genetic study. Hum Pathol. 2018;72:100-106 pubmed publisher
    ..have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, β-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial ..
  88. Modlin I, Kidd M, Filosso P, Roffinella M, Lewczuk A, Cwikla J, et al. Molecular strategies in the management of bronchopulmonary and thymic neuroendocrine neoplasms. J Thorac Dis. 2017;9:S1458-S1473 pubmed publisher
    ..most often secreting ACTH (40% of tumors) but both tumor groups share secretion of common biomarkers including chromogranin A and 5-HIAA. Consistently effective and accurate circulating biomarkers are, however, currently unavailable...
  89. Simon Chazottes D, Wu H, Parmer R, Rozansky D, Szpirer J, Levan G, et al. Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. Genomics. 1993;17:252-5 pubmed
    b>Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension. In the human genome, its locus has previously been positioned on the long arm of Chromosome 14 in the 14q32 region...
  90. Sciarra A. Neuroendocrine differentiation in prostate adenocarcinoma. Eur Urol. 2007;52:1373 pubmed
  91. Mahapatra N, Taupenot L, Courel M, Mahata S, O Connor D. The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry. 2008;47:7167-78 pubmed publisher
    ..Recent studies suggest an important role of chromogranin A (CHGA) in the regulated secretory pathway in neuroendocrine cells, but the mechanism by which CHGA enters the ..
  92. Yang X, Yang Y, Li Z, Cheng C, Yang T, Wang C, et al. Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis. PLoS ONE. 2015;10:e0124884 pubmed publisher
    In previous decades, chromogranin A (CgA) has been demonstrated to be the most promising biomarker for the diagnosis of neuroendocrine tumors (NETs), but its diagnostic value is still controversial...