Gene Symbol: CHRNA7
Description: cholinergic receptor nicotinic alpha 7 subunit
Alias: CHRNA7-2, NACHRA7, neuronal acetylcholine receptor subunit alpha-7, a7 nicotinic acetylcholine receptor, alpha 7 neuronal nicotinic acetylcholine receptor, alpha-7 nicotinic cholinergic receptor subunit, cholinergic receptor, nicotinic alpha 7, cholinergic receptor, nicotinic, alpha 7 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 7, neuronal acetylcholine receptor protein, alpha-7 chain
Species: human
Products:     CHRNA7

Top Publications

  1. Small D, Maksel D, Kerr M, Ng J, Hou X, Chu C, et al. The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem. 2007;101:1527-38 pubmed
    ..Instead, we speculate that Abeta may exert its effects by altering the packing of lipids within the plasma membrane, which could, in turn, influence the function of a variety of receptors and channels on the cell surface. ..
  2. Mathew S, Law A, Lipska B, Dávila García M, Zamora E, Mitkus S, et al. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Hum Mol Genet. 2007;16:2921-32 pubmed
    ..Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression. ..
  3. Carson R, Craig D, McGuinness B, Johnston J, O Neill F, Passmore A, et al. Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease. J Med Genet. 2008;45:244-8 pubmed
    ..We sought to investigate the role of the alpha7 nicotinic acetylcholine receptor gene (CHRNA7) in influencing risk of AD in a large population...
  4. Arredondo J, Chernyavsky A, Jolkovsky D, Pinkerton K, Grando S. Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke. FASEB J. 2008;22:1356-68 pubmed publisher
  5. Roncarati R, Seredenina T, Jow B, Jow F, Papini S, Kramer A, et al. Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. Assay Drug Dev Technol. 2008;6:181-93 pubmed publisher
    ..This recombinant cell system is useful for characterization of alpha7 nAChRs and to study the mechanism of action of chemical modulators, in particular the detection of PAMs capable of slowing receptor desensitization kinetics. ..
  6. Peng X, Katz M, Gerzanich V, Anand R, Lindstrom J. Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol Pharmacol. 1994;45:546-54 pubmed
  7. Barabash A, Marcos A, Ancín I, Vázquez Alvarez B, De Ugarte C, Gil P, et al. APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease. Neurobiol Aging. 2009;30:1254-64 pubmed
    We have investigated whether the -86 C/T promoter polymorphism in CHRNA7 gene, the signal peptide polymorphism of the alpha1-antichymotripsin (ACT) gene or the APOE genotype are associated with an increased risk of mild cognitive ..
  8. Westman M, Engstrom M, Catrina A, Lampa J. Cell specific synovial expression of nicotinic alpha 7 acetylcholine receptor in rheumatoid arthritis and psoriatic arthritis. Scand J Immunol. 2009;70:136-40 pubmed publisher
    ..These results indicate the importance of alpha7nAChR and cholinergic mechanisms in arthritis pathogenesis and implicate specific cholinergic modulation as a potential anti-inflammatory therapeutic strategy in joint inflammation...
  9. Sinkus M, Lee M, Gault J, Logel J, Short M, Freedman R, et al. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 2009;1291:1-11 pubmed publisher
    ..Among the putative candidate genes in this area are the alpha7 nicotinic acetylcholine receptor gene (CHRNA7) and its partial duplication, CHRFAM7A...

More Information


  1. Al Wadei H, Al Wadei M, Masi T, Schuller H. Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells. Lung Cancer. 2010;69:33-9 pubmed publisher
    ..This selective imbalance in stimulatory and inhibitory signaling may contribute to the development and progression of small airway-derived adenocarcinoma in women who smoke. ..
  2. Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, et al. Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene. Am J Psychiatry. 2006;163:1832-4 pubmed
    ..Chromosome 15q14 harbors the alpha-7 nicotinic receptor subunit gene (CHRNA7) and a hybrid gene of unknown function (CHRFAM7A)...
  3. Arredondo J, Chernyavsky A, Jolkovsky D, Pinkerton K, Grando S. Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB J. 2006;20:2093-101 pubmed
  4. Fan J, Ma J, Li X, Zhang C, Sun W, He G, et al. Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia. Schizophr Res. 2006;84:222-7 pubmed
    The human alpha-7 neuronal nicotinic receptor subunit (CHRNA7) gene, located at chromosome 15q13.2, represents a strong candidate gene for schizophrenia...
  5. Wang X, Liu Y, Wang Q, Tsuruoka M, Ohta K, Wu S, et al. Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues. Cell Tissue Res. 2010;340:347-55 pubmed publisher
    ..Our results may be pertinent to a better understanding of the relationships among smoking, nicotine, and periodontitis. ..
  6. van der Zanden E, Hilbers F, Verseijden C, van den Wijngaard R, Skynner M, Lee K, et al. Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. Neuroimmunomodulation. 2012;19:255-65 pubmed publisher
    ..As previous data suggest that the ?7 nicotinic acetylcholine receptor (CHRNA7) and its duplicated variant CHRFAM7A may specifically participate in the inflammatory response of monocytes, we ..
  7. Sinkus M, Wamboldt M, Barton A, Fingerlin T, Laudenslager M, Leonard S. The ?7 nicotinic acetylcholine receptor and the acute stress response: maternal genotype determines offspring phenotype. Physiol Behav. 2011;104:321-6 pubmed publisher
    ..Therefore, the ?7 nicotinic acetylcholine receptor gene (CHRNA7) may be associated with cortisol stress response...
  8. Ballester L, Capó Vélez C, Garcia Beltran W, Ramos F, Vázquez Rosa E, Ríos R, et al. Up-regulation of the neuronal nicotinic receptor ?7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder. J Biol Chem. 2012;287:3079-86 pubmed publisher
    ..In summary, CXCR4 activation induces up-regulation of ?7-nAChR, causing cell death, suggesting that ?7-nAChR is a previously unrecognized contributor to the neurotoxicity associated with HIV infection. ..
  9. Raux G, Bonnet Brilhault F, Louchart S, Houy E, Gantier R, Levillain D, et al. The -2 bp deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit. Mol Psychiatry. 2002;7:1006-11 pubmed
    ..Two related alpha 7 genes (CHRNA7 and CHRNA7-like gene) resulting from a partial duplication (from exon 5 to exon 10) are present in the human ..
  10. Muller D, Chiesa A, Mandelli L, De Luca V, De Ronchi D, Jain U, et al. Correlation of a set of gene variants, life events and personality features on adult ADHD severity. J Psychiatr Res. 2010;44:598-604 pubmed publisher
    ..Common polymorphisms within a set of nine important candidate genes (SLC6A3, DBH, DRD4, DRD5, HTR2A, CHRNA7, BDNF, PRKG1 and TAAR9) were genotyped for each subject...
  11. Szafranski P, Schaaf C, Person R, Gibson I, Xia Z, Mahadevan S, et al. Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?. Hum Mutat. 2010;31:840-50 pubmed publisher
    ..6-Mb microduplications and 55 smaller 350-680-kb microduplications at 15q13.2-q13.3 involving the CHRNA7 gene that were detected by clinical microarray analysis...
  12. Schraufstatter I, DiScipio R, Khaldoyanidi S. Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells. J Stem Cells. 2009;4:203-15 pubmed publisher
    ..These findings reveal an involvement of the non-neural cholinergic system in regulation of hMSC migration. ..
  13. de Lucas Cerrillo A, Maldifassi M, Arnalich F, Renart J, Atienza G, Serantes R, et al. Function of partially duplicated human ?77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response. J Biol Chem. 2011;286:594-606 pubmed publisher
    The neuronal ?7 nicotinic receptor subunit gene (CHRNA7) is partially duplicated in the human genome forming a hybrid gene (CHRFAM7A) with the novel FAM7A gene...
  14. Houy E, Raux G, Thibaut F, Belmont A, Demily C, Allio G, et al. The promoter -194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit. Mol Psychiatry. 2004;9:320-2 pubmed
    ..shown a significant association between the presence of at least one -2 bp deletion located within exon 6 of the CHRNA7-like gene and the P50 abnormality in the general population...
  15. Schedel A, Thornton S, Schloss P, Kluter H, Bugert P. Human platelets express functional alpha7-nicotinic acetylcholine receptors. Arterioscler Thromb Vasc Biol. 2011;31:928-34 pubmed publisher
  16. Yasui D, Scoles H, Horike S, Meguro Horike M, Dunaway K, Schroeder D, et al. 15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. Hum Mol Genet. 2011;20:4311-23 pubmed publisher
    ..Remarkably, two of these overlapping PWS-IC- and MeCP2-bound sites mapped to sites flanking CHRNA7 (cholinergic receptor nicotinic alpha 7) encoding the cholinergic receptor, nicotinic, alpha 7...
  17. Finlay Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S. Transcriptional repression of the ?7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2? (AP-2?). J Biol Chem. 2011;286:42123-32 pubmed publisher
    The CHRNA7 gene, which encodes the ?7 nicotinic acetylcholine receptor (?7*nAChR), has been implicated as a candidate gene in schizophrenia...
  18. Plummer H, Dhar M, Schuller H. Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir Res. 2005;6:29 pubmed
    ..The alpha7 nicotinic receptor protein is expressed in fewer cell lines, and the tobacco carcinogen NNK increases alpha7 nicotinic receptor protein levels. ..
  19. Broadbent S, Groot Kormelink P, Krashia P, Harkness P, Millar N, Beato M, et al. Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors. Mol Pharmacol. 2006;70:1350-7 pubmed
    ..This raises the possibility of a novel regulatory role for the beta3 subunit on neuronal nicotinic signaling in the central nervous system. ..
  20. Heeschen C, Weis M, Aicher A, Dimmeler S, Cooke J. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest. 2002;110:527-36 pubmed
    ..To our knowledge, this is the first description of a cholinergic angiogenic pathway, and it suggests a novel avenue for therapeutic modulation of angiogenesis. ..
  21. Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya K, et al. Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. Neurosci Res. 2007;57:194-202 pubmed
    Several previous studies have reported a significant linkage between markers in the alpha 7 nicotinic cholinergic receptor subunit (CHRNA7) gene and either schizophrenia or the P50 sensory gating deficit, a schizophrenia endophenotype...
  22. Stergiakouli E, Hamshere M, Holmans P, Langley K, Zaharieva I, Hawi Z, et al. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. Am J Psychiatry. 2012;169:186-94 pubmed
    ..These included cholesterol-related and CNS development pathways. At the level of individual genes, CHRNA7, which encodes a nicotinic receptor subunit previously implicated in neuropsychiatric disorders, was affected by ..
  23. Schuller H, Jull B, Sheppard B, Plummer H. Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. Eur J Pharmacol. 2000;393:265-77 pubmed
    ..Similarly, up-regulation of one or several components of this nicotinic receptor pathway in smokers may be an important factor for the development of small cell lung carcinoma. ..
  24. Masurel Paulet A, Andrieux J, Callier P, Cuisset J, Le Caignec C, Holder M, et al. Delineation of 15q13.3 microdeletions. Clin Genet. 2010;78:149-61 pubmed publisher
    ..with this microdeletion generally present with relatively consistent breakpoints at BP4 and BP5, which include the CHRNA7 gene. About 100 index cases have been reported since the first publication in 2008...
  25. Flomen R, Davies A, Di Forti M, La Cascia C, Mackie Ogilvie C, Murray R, et al. The copy number variant involving part of the alpha7 nicotinic receptor gene contains a polymorphic inversion. Eur J Hum Genet. 2008;16:1364-71 pubmed publisher
    The alpha7 nicotinic acetylcholine receptor gene (CHRNA7) is located at 15q13-q14 in a region that is strongly linked to the P50 sensory gating deficit, an endophenotype of schizophrenia and bipolar disorder...
  26. Gault J, Robinson M, Berger R, Drebing C, Logel J, Hopkins J, et al. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics. 1998;52:173-85 pubmed
    The human alpha7 neuronal nicotinic acetylcholine receptor gene (HGMW-approved symbol CHRNA7) has been characterized from genomic clones...
  27. Riley B, Williamson M, Collier D, Wilkie H, Makoff A. A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. Genomics. 2002;79:197-209 pubmed human 15q13-q14, which contains a strong candidate in the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7) and is partly duplicated, complicating further genetic analysis...
  28. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, et al. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002;59:1085-96 pubmed
    The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has been implicated as a candidate gene for schizophrenia, and for an auditory sensory processing deficit found in the disease, by both genetic linkage at 15q14 ..
  29. Wang H, Yu M, Ochani M, Amella C, Tanovic M, Susarla S, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421:384-8 pubmed
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway. ..
  30. Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J, Umemura S, et al. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Am J Physiol Cell Physiol. 2003;285:C567-74 pubmed
    ..In addition, nAChR alpha 7 may regulate the AC activity via Ca2+ within lipid rafts. ..
  31. Williams M, Burton B, Urrutia A, Shcherbatko A, Chavez Noriega L, Cohen C, et al. Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells. J Biol Chem. 2005;280:1257-63 pubmed
    ..Thus, ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells. ..
  32. Wong H, Yu L, Lam E, Tai E, Wu W, Cho C. Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol Appl Pharmacol. 2007;221:261-7 pubmed
    ..These data reveal the contributory role alpha7-nAChR and beta-adrenoceptors in the tumorigenesis of colon cancer cells and partly elucidate the carcinogenic action of cigarette smoke on colon cancer. ..
  33. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, et al. alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem. 2001;276:13541-6 pubmed
    ..These findings indicate that the alpha7 nicotinic receptor transduces signals to PI3K in a cascade, which ultimately contributes to a neuroprotective effect. This might form the basis of a new treatment for AD. ..
  34. Chernyavsky A, Arredondo J, Galitovskiy V, Qian J, Grando S. Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases. Am J Physiol Cell Physiol. 2010;299:C903-11 pubmed publisher
    ..Thus, there exists a previously not appreciated network of noncanonical auto/paracrine ligands of nAChR of the Ly-6 protein family, which merits further investigations. ..
  35. Wu J, Chruscinski A, de Jesus Perez V, Singh H, Pitsiouni M, Rabinovitch M, et al. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. J Cell Biochem. 2009;108:433-46 pubmed publisher
    ..Other subunits play a modulatory role. These findings may have therapeutic implications for diseases characterized by pathological angiogenesis. ..
  36. Kunii Y, Zhang W, Xu Q, Hyde T, McFadden W, Shin J, et al. CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders. Am J Psychiatry. 2015;172:1122-30 pubmed publisher
    b>CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), is involved in cognition through interneuron modulation of dopamine and glutamate signaling...
  37. Chen W, Huang C, Cheng W, Hung C, Huang M, Tai C, et al. Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil. Tumour Biol. 2015;36:9537-44 pubmed publisher
    ..The results clearly showed that depletion of A7-nAChR suppressed the drug sensitivity of gastric cancer cells to 5-FU treatment. ..
  38. Sakata K, Overacre A. Promoter IV-BDNF deficiency disturbs cholinergic gene expression of CHRNA5, CHRM2, and CHRM5: effects of drug and environmental treatments. J Neurochem. 2017;143:49-64 pubmed publisher
    ..EET also increased levels of CHRNA7, CHT, and ChAT, again only in the KIV frontal cortex...
  39. Shaw J, Oliver E, Lee K, Entrican G, Jabbour H, Critchley H, et al. Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. Am J Pathol. 2010;177:2509-15 pubmed publisher
    ..05), which was negated by cotreatment with nAChR?-7 antagonist. Smoking targets human FTs via nAChR?-7 to increase tubal PROKR1, leading to alterations in the tubal microenvironment that could predispose to EP...
  40. Counts S, He B, Che S, Ikonomovic M, DeKosky S, Ginsberg S, et al. Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease. Arch Neurol. 2007;64:1771-6 pubmed
    ..Alternatively, putative competitive interactions of this receptor with beta-amyloid may provide a pathogenic mechanism for NB dysfunction. Increasing NB alpha7 nAChR expression may serve as a marker for the progression of AD. ..
  41. Arroyo S, Bennett C, Aziz D, Brown S, Hestrin S. Prolonged disynaptic inhibition in the cortex mediated by slow, non-?7 nicotinic excitation of a specific subset of cortical interneurons. J Neurosci. 2012;32:3859-64 pubmed publisher
    ..In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits. ..
  42. Williams N, Franke B, Mick E, Anney R, Freitag C, Gill M, et al. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry. 2012;169:195-204 pubmed
    ..Duplications spanning the CHRNA7 gene at chromosome 15q13.3 were associated with ADHD in single-locus analysis...
  43. Holmes C, Plichta J, Gamelli R, Radek K. Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin. Shock. 2017;47:175-183 pubmed publisher
    ..We established that protein levels, but not gene expression, of the α7 nicotinic acetylcholine receptor (CHRNA7) were significantly reduced in both donor and burn margin skin...
  44. Manchia M, Viggiano E, Tiwari A, Renou J, Jain U, De Luca V, et al. Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores. World J Biol Psychiatry. 2010;11:506-10 pubmed publisher
    ..In this study we hypothesized that the allele 113bp in D15S1360 marker at CHRNA7 and the 2 bp deletion allele at CHRFAM7A are associated with increased smoking in a sample of 90 DSM-IV patients ..
  45. Li D, Zhao T, Xin R, Wang Y, Fei Y, Shen F. Activation of α7 nicotinic acetylcholine receptor protects against oxidant stress damage through reducing vascular peroxidase-1 in a JNK signaling-dependent manner in endothelial cells. Cell Physiol Biochem. 2014;33:468-78 pubmed publisher
    ..These results provide the first evidence that activation of α7nAChR protects against oxidant stress-induced damage by suppressing VPO-1 in a JNK signaling pathway-dependent manner in endothelial cells. ..
  46. Spurny R, Debaveye S, Farinha A, Veys K, Vos A, Gossas T, et al. Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2015;112:E2543-52 pubmed publisher
    ..This work presents a structural framework for different allosteric binding sites in the α7 nAChR and paves the way for future development of novel allosteric modulators with therapeutic potential. ..
  47. Castillo M, Mulet J, Gutierrez L, Ortiz J, Castelán F, Gerber S, et al. Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. J Biol Chem. 2005;280:27062-8 pubmed
    ..Therefore, hRIC-3 can act as a specific regulator of receptor expression at different levels. ..
  48. Liu Y, Hao S, Yang B, Fan Y, Qin X, Chen Y, et al. Wnt/?-catenin signaling plays an essential role in ?7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model. Biochem Pharmacol. 2017;140:115-123 pubmed publisher
    ..These results suggest that endogenous ?7-nAChR mechanisms play a crucial role in a mouse PD model via regulation of Wnt/?-catenin signaling. ..
  49. Bartos M, Price K, Lummis S, Bouzat C. Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. J Biol Chem. 2009;284:21478-87 pubmed publisher
    ..Thus, position 57 at the complementary face is a key determinant of the high selectivity of morantel for alpha7. These results provide new information for further progress in drug design. ..
  50. Bacchelli E, Battaglia A, Cameli C, Lomartire S, Tancredi R, Thomson S, et al. Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility. Am J Med Genet A. 2015;167A:715-23 pubmed publisher
    ..Whether the reciprocal microduplication is pathogenic is less certain. CHRNA7, encoding for the alpha7 subunit of the neuronal nicotinic acetylcholine receptor, is considered the likely ..
  51. Wang W, Chin Sheng H, Kuo L, Wei P, Lien Y, Lin F, et al. NNK enhances cell migration through ?7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer. Ann Surg Oncol. 2012;19 Suppl 3:S580-8 pubmed publisher
    ..NNK enhanced gastric cancer metastasis through alpha7-nAChR and fibronectin-one of the hallmarks of epithelial mesenchymal transition. ..
  52. Nemecz A, Taylor P. Creating an ?7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses. J Biol Chem. 2011;286:42555-65 pubmed publisher
    ..We also present a pentameric humanoid nAChR extracellular domain with the structural determination of the ?7 nAChR glycosylation site. ..
  53. Klemettilä J, Kampman O, Solismaa A, Lyytikäinen L, Seppala N, Viikki M, et al. Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia. Eur Psychiatry. 2017;40:13-19 pubmed publisher
    ..05) serum NPY concentration related SNPs among ?7 nicotinic acetylcholine receptor gene CHRNA7, insulin receptor gene INSR, leptin receptor gene LEPR, glucocorticoid receptor (GR) gene NR3C1, and NPY gene...
  54. Sudhaman S, Muthane U, Behari M, Govindappa S, Juyal R, Thelma B. Evidence of mutations in RIC3 acetylcholine receptor chaperone as a novel cause of autosomal-dominant Parkinson's disease with non-motor phenotypes. J Med Genet. 2016;53:559-66 pubmed publisher
    ..RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit α-7 (CHRNA7)...
  55. Ancín I, Barabash A, Vázquez Álvarez B, Santos J, Sánchez Morla E, Martinez J, et al. Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia. Psychiatr Genet. 2010;20:289-97 pubmed publisher
    ..evidence in both human and animal studies suggests ?7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) as a suitable functional candidate for genetic studies in psychiatric populations...
  56. Li C, Liao H, Chen C. Identification of molecular variants at the promoter region of the human alpha 7 neuronal nicotinic acetylcholine receptor subunit gene but lack of association with schizophrenia. Neurosci Lett. 2004;372:1-5 pubmed
    ..Hence, in this study, we did not find mutations in the human alpha7 neuronal nicotinic receptor subunit gene that are associated with schizophrenia in our population. ..
  57. Braga I, Silva P, Furuya T, Santos L, Pires B, Mazzotti D, et al. Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2015;30:139-44 pubmed publisher
    ..We evaluated apolipoprotein E (APOE) and ?7 nicotinic receptor (CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to ChEIs in a ..
  58. Ramos F, Delgado Vélez M, Ortiz Ã, Báez Pagán C, Quesada O, Lasalde Dominicci J. Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol. 2016;22:327-35 pubmed publisher
    ..Hence, we studied both CHRNA7 and CHRFAM7A regulation patterns in various gp120IIIB in vitro conditions...
  59. Neri M, Bonassi S, Russo P. Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia. Curr Drug Targets. 2012;13:636-43 pubmed
    ..Genetic polymorphisms of CHRNA7 and CHRFAM7A, a fusion gene containing a partial CHRNA7 duplication, have been investigated as possible ..
  60. Sullivan J, Blair L, Alnajar A, Aziz T, Chipitsyna G, Gong Q, et al. Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma. Histol Histopathol. 2011;26:893-904 pubmed publisher
  61. Graham A, Ray M, Perry E, Jaros E, Perry R, Volsen S, et al. Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus. J Chem Neuroanat. 2003;25:97-113 pubmed
    ..Immunoreactivity to all subunits was noted in association with blood vessels. These results indicate the involvement of multiple nAChR subtypes in the modulation of both neuronal and non-neuronal functions in the human hippocampus. ..
  62. Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, et al. Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology. J Neurol Sci. 2004;225:39-49 pubmed
    ..Increased astrocyte alpha7 nAChRs in AD may be associated with inflammatory mechanisms related to degenerative processes specific to this disease. ..
  63. Nie H, Shi S, Lukas R, Zhao W, Sun Y, Yin M. Activation of ?7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-?7 nAChR-hAPP695 cells. Brain Res. 2010;1356:112-20 pubmed publisher
    ..The constructed SH-EP1-?7 nAChR-hAPP695 cell line might be useful for screening specific nAChR agonists against AD. ..
  64. Colville A, Iancu O, Oberbeck D, Darakjian P, Zheng C, Walter N, et al. Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice. Genes Brain Behav. 2017;16:462-471 pubmed publisher
    ..greenyellow) that was significantly enriched in genes associated with receptor signaling activity including Chrna7, Grin2a, Htr2a and Oprd1...
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    ..Response inhibition (MFFT, Stroop, CPT Loading Phase, TOL) was associated with variants in CHRNA2, CHRNA4, CHRNA5, CHRNA7, CHRNA9, CHRNA10, CHRNB2 and CHRNB3...
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