CHRNA3

Summary

Gene Symbol: CHRNA3
Description: cholinergic receptor nicotinic alpha 3 subunit
Alias: LNCR2, NACHRA3, PAOD2, neuronal acetylcholine receptor subunit alpha-3, cholinergic receptor, nicotinic alpha 3, cholinergic receptor, nicotinic, alpha 3 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 3, neuronal nicotinic acetylcholine receptor, alpha3 subunit
Species: human
Products:     CHRNA3

Top Publications

  1. Thorgeirsson T, Gudbjartsson D, Surakka I, Vink J, Amin N, Geller F, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet. 2010;42:448-53 pubmed publisher
    ..Nominal associations with lung cancer were observed at both 8p11 (rs6474412[T], odds ratio (OR) = 1.09, P = 0.04) and 19q13 (rs4105144[C], OR = 1.12, P = 0.0006). ..
  2. Gallego X, Ruiz Medina J, Valverde O, Molas S, Robles N, Sabriá J, et al. Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol. 2012;46:205-15 pubmed publisher
    ..water) preference test. These results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects. ..
  3. Schwartz A, Cote M, Wenzlaff A, Land S, Amos C. Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. J Thorac Oncol. 2009;4:1195-201 pubmed publisher
    ..This region includes nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5...
  4. Kohno T, Kunitoh H, Mimaki S, Shiraishi K, Kuchiba A, Yamamoto S, et al. Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma. J Thorac Oncol. 2011;6:813-7 pubmed publisher
    ..of 377 cases and 325 controls, which had been previously subjected to association studies on GWAS genes, CHRNA3, TERT, and HLA-DQA1...
  5. Pillai S, Kong X, Edwards L, Cho M, Anderson W, Coxson H, et al. Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;182:1498-505 pubmed publisher
    ..between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms ..
  6. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, Matakidou A, et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet. 2008;40:1407-9 pubmed publisher
    ..33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)). ..
  7. Flora A, Schulz R, Benfante R, Battaglioli E, Terzano S, Clementi F, et al. Transcriptional regulation of the human alpha5 nicotinic receptor subunit gene in neuronal and non-neuronal tissues. Eur J Pharmacol. 2000;393:85-95 pubmed
  8. Lambrechts D, Buysschaert I, Zanen P, Coolen J, Lays N, Cuppens H, et al. The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. Am J Respir Crit Care Med. 2010;181:486-93 pubmed publisher
    ..This association was independent of pack-years smoking, suggesting that nAChR is causally involved in alveolar destruction as a potentially shared pathogenic mechanism in lung cancer and COPD. ..
  9. Rana B, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen J, et al. Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. J Pharmacol Exp Ther. 2009;331:419-28 pubmed publisher
    ..Genes encoding these subunits (CHRNA3, CHRNA5, and CHRNB4) are clustered on human chromosome 15q24...

More Information

Publications62

  1. . Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010;42:441-7 pubmed publisher
    ..The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.03, standard error (s.e.) = 0.053, P = 2.8 x 10(-73))...
  2. Saccone N, Schwantes An T, Wang J, Grucza R, Breslau N, Hatsukami D, et al. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav. 2010;9:741-50 pubmed publisher
    Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5-CHRNA3-CHRNB4 gene cluster, harbors variants strongly associated with nicotine dependence, other smoking behaviors, lung cancer and chronic ..
  3. Winterer G, Mittelstrass K, Giegling I, Lamina C, Fehr C, Brenner H, et al. Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1448-58 pubmed publisher
    Recent studies strongly support an association of the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 with nicotine dependence (ND). However, the precise genotype-phenotype relationship is still unknown...
  4. Shiraishi K, Kohno T, Kunitoh H, Watanabe S, Goto K, Nishiwaki Y, et al. Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis. 2009;30:65-70 pubmed publisher
    ..These results strongly indicate that CHRNA SNPs confer lung cancer susceptibility in a small subset of Japanese in a smoking-independent manner. ..
  5. Spitz M, Amos C, Dong Q, Lin J, Wu X. The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst. 2008;100:1552-6 pubmed publisher
    ..Thus, we conclude that the variants are implicated both in smoking behavior and more directly in lung cancer risk. ..
  6. Bierut L, Stitzel J, Wang J, Hinrichs A, Grucza R, Xuei X, et al. Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry. 2008;165:1163-71 pubmed publisher
    ..investigate the role of genetic variation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk of smoking...
  7. Kaur Knudsen D, Nordestgaard B, Bojesen S. CHRNA3 genotype, nicotine dependence, lung function and disease in the general population. Eur Respir J. 2012;40:1538-44 pubmed publisher
    The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and ..
  8. Le Marchand L, Derby K, Murphy S, Hecht S, Hatsukami D, Carmella S, et al. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res. 2008;68:9137-40 pubmed publisher
    A locus at 15q24/15q25.1, which includes the nicotinic acetylcholine receptor A subunits 3 and 5 (CHRNA3 and CHRNA5) genes, has recently been associated with lung cancer risk, self-reported number of cigarettes smoked per day, and a ..
  9. Li M, Yoon D, Lee J, Han B, Niu T, Payne T, et al. Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. PLoS ONE. 2010;5:e12183 pubmed publisher
    Multiple genome-wide and targeted association studies reveal a significant association of variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 with nicotine dependence...
  10. Caporaso N, Gu F, Chatterjee N, Sheng Chih J, Yu K, Yeager M, et al. Genome-wide and candidate gene association study of cigarette smoking behaviors. PLoS ONE. 2009;4:e4653 pubmed publisher
    ..In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been ..
  11. Freathy R, Kazeem G, Morris R, Johnson P, Paternoster L, Ebrahim S, et al. Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. Int J Epidemiol. 2011;40:1617-28 pubmed publisher
    ..Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association ..
  12. Keskitalo K, Broms U, Heliövaara M, Ripatti S, Surakka I, Perola M, et al. Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet. 2009;18:4007-12 pubmed publisher
    A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity...
  13. Gu M, Dong X, Zhang X, Wang X, Qi Y, Yu J, et al. Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis. PLoS ONE. 2012;7:e37970 pubmed publisher
    ..We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two polymorphisms (CHRNA3 gene: rs1051730 and AGPHD1 gene: rs8034191) on 15q25.1...
  14. Cho M, Boutaoui N, Klanderman B, Sylvia J, Ziniti J, Hersh C, et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010;42:200-2 pubmed publisher
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83). ..
  15. Landi M, Chatterjee N, Yu K, Goldin L, Goldstein A, Rotunno M, et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet. 2009;85:679-91 pubmed publisher
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma. ..
  16. Wang Y, Broderick P, Matakidou A, Eisen T, Houlston R. Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk. PLoS ONE. 2011;6:e19085 pubmed publisher
    Genetic variants at the 15q25 CHRNA5-CHRNA3 locus have been shown to influence lung cancer risk however there is controversy as to whether variants have a direct carcinogenic effect on lung cancer risk or impact indirectly through smoking ..
  17. Munafo M, Johnstone E, Walther D, Uhl G, Murphy M, Aveyard P. CHRNA3 rs1051730 genotype and short-term smoking cessation. Nicotine Tob Res. 2011;13:982-8 pubmed publisher
    ..We investigated the potential association of rs1051730 genotype with reduced likelihood of smoking cessation in 2 cohorts of treatment-seeking smokers in primary care in the United Kingdom...
  18. Yang L, Qiu F, Lu X, Huang D, Ma G, Guo Y, et al. Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese. PLoS ONE. 2012;7:e46071 pubmed publisher
    ..Two SNPs (rs6495309 and rs1051730) located in nicotinic acetylcholine receptor alpha 3 (CHRNA3) gene were genotyped in 1511 patients with COPD, 1559 lung cancer cases and 1677 controls in southern and eastern ..
  19. Schlaepfer I, Hoft N, Collins A, Corley R, Hewitt J, Hopfer C, et al. The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry. 2008;63:1039-46 pubmed publisher
    ..01 and p < .001). Variations in A5A3B4 genes might influence behaviors that promote early age of experimentation with drugs. ..
  20. Liu P, Vikis H, Wang D, Lu Y, Wang Y, Schwartz A, et al. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008;100:1326-30 pubmed publisher
    ..1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer...
  21. Hung R, McKay J, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452:633-7 pubmed publisher
    ..region contains several genes, including three that encode nicotinic acetylcholine receptor subunits (CHRNA5, CHRNA3 and CHRNB4)...
  22. Stevens V, Bierut L, Talbot J, Wang J, Sun J, Hinrichs A, et al. Nicotinic receptor gene variants influence susceptibility to heavy smoking. Cancer Epidemiol Biomarkers Prev. 2008;17:3517-25 pubmed publisher
    ..Compared with the most common allele, two separate groups of single nucleotide polymorphisms (SNP) in the CHRNA5-CHRNA3-CHRNB4 gene cluster were associated with heavy smoking with a very high statistical significance...
  23. Girard N, Lou E, Azzoli C, Reddy R, Robson M, Harlan M, et al. Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report. Clin Cancer Res. 2010;16:755-63 pubmed publisher
    ..polymorphisms rs763317 (intron 1) and T790M (exon 20) in the EGFR gene were determined by direct sequencing, and CHRNA3 nicotinic acetylcholine receptor single nucleotide polymorphisms (rs8034191 and rs1051730) were genotyped as part ..
  24. Picciotto M, Kenny P. Molecular mechanisms underlying behaviors related to nicotine addiction. Cold Spring Harb Perspect Med. 2013;3:a012112 pubmed publisher
    ..Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the ?5, ?3, and ?4 nAChR subunits, respectively, has been shown to increase ..
  25. Zhou H, Yang J, Li D, Xiao J, Wang B, Wang L, et al. Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. J Hum Genet. 2012;57:738-46 pubmed publisher
    ..SNPs) in the chromosome 15q25 region that includes iron-responsive element binding protein 2 gene (IREB2) and CHRNA3/5 in non-Asian populations...
  26. Amos C, Wu X, Broderick P, Gorlov I, Gu J, Eisen T, et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 2008;40:616-22 pubmed publisher
    ..1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets...
  27. Thorgeirsson T, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson K, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008;452:638-642 pubmed publisher
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases. ..
  28. Pillai S, Ge D, Zhu G, Kong X, Shianna K, Need A, et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet. 2009;5:e1000421 pubmed publisher
    ..1371/journal.pgen.1000429). The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD. CHRNA3/5 is the same locus that has been implicated in the risk of lung cancer.
  29. Gallego X, Molas S, Amador Arjona A, Marks M, Robles N, Murtra P, et al. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino Acids. 2012;43:897-909 pubmed publisher
  30. Saccone N, Saccone S, Goate A, Grucza R, Hinrichs A, Rice J, et al. In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genet. 2008;9:58 pubmed publisher
    ..We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American ..
  31. Weiss R, Baker T, Cannon D, von Niederhausern A, Dunn D, Matsunami N, et al. A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet. 2008;4:e1000125 pubmed publisher
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies. ..
  32. Improgo M, Scofield M, Tapper A, Gardner P. The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol. 2010;92:212-26 pubmed publisher
    ..Here, we review this body of work, focusing on the clustered nicotinic acetylcholine receptor genes and evaluating their role in nicotine addiction and lung cancer. ..
  33. Broms U, Wedenoja J, Largeau M, Korhonen T, Pitkäniemi J, Keskitalo Vuokko K, et al. Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. Nicotine Tob Res. 2012;14:720-33 pubmed publisher
    ..In this study, we included all 15 tagging single nucleotide polymorphisms (SNPs) within the CHRNA5-CHRNA3-CHRNB4 cluster and tested associations with 30 smoking-related phenotypes.
  34. Wassenaar C, Dong Q, Wei Q, Amos C, Spitz M, Tyndale R. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst. 2011;103:1342-6 pubmed publisher
    Genetic variations in the CYP2A6 nicotine metabolic gene and the CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) nicotinic gene cluster have been independently associated with lung cancer...
  35. Breitling L, Dahmen N, Mittelstrass K, Illig T, Rujescu D, Raum E, et al. Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes. Biol Psychiatry. 2009;65:691-5 pubmed publisher
  36. Lee J, Yoo S, Kang H, Jin G, Bae E, Choi Y, et al. A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population. J Korean Med Sci. 2012;27:1536-40 pubmed publisher
    ..The rs6495309C > T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (CHRNA3) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control ..
  37. Ducci F, Kaakinen M, Pouta A, Hartikainen A, Veijola J, Isohanni M, et al. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Biol Psychiatry. 2011;69:650-60 pubmed publisher
    CHRNA5-CHRNA3-CHRNB4 and TTC12-ANKK1-DRD2 gene-clusters influence smoking behavior. Our aim was to test developmental changes in their effects as well as the interplays between them and with nongenetic factors...
  38. Li M, Xu Q, Lou X, Payne T, Niu T, Ma J. Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:745-56 pubmed publisher
    Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic ..
  39. Liu J, Tozzi F, Waterworth D, Pillai S, Muglia P, Middleton L, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet. 2010;42:436-40 pubmed publisher
    ..45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits...
  40. Amos C, Gorlov I, Dong Q, Wu X, Zhang H, Lu E, et al. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst. 2010;102:1199-205 pubmed publisher
    ..cancer, we genotyped 34 single-nucleotide polymorphisms (SNPs) in this region (including LOC123688, PSMA4, CHRNA5, CHRNA3, and CHRNB4 genes) in 467 African American patients with lung cancer and 388 frequency-matched African American ..
  41. Zhang H, Kranzler H, Poling J, Gelernter J. Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. Neuropsychopharmacology. 2010;35:2211-24 pubmed publisher
    Variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster have been associated with nicotine dependence (ND) and ND-related traits...
  42. Saccone N, Saccone S, Hinrichs A, Stitzel J, Duan W, Pergadia M, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:453-66 pubmed publisher
    ..the multiple tests across this gene family, we found significant association for two distinct loci in the CHRNA5-CHRNA3-CHRNB4 gene cluster, one locus in the CHRNB3-CHRNA6 gene cluster, and a fourth, novel locus in the CHRND-CHRNG ..
  43. Hong L, Hodgkinson C, Yang Y, Sampath H, Ross T, Buchholz B, et al. A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. Proc Natl Acad Sci U S A. 2010;107:13509-14 pubmed publisher
    ..Identifying where and how brain circuits link genes to smoking provides practical neural circuitry targets for new treatment development. ..
  44. Freathy R, Ring S, Shields B, Galobardes B, Knight B, Weedon M, et al. A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet. 2009;18:2922-7 pubmed publisher
    ..association between a common polymorphism (rs1051730) in the nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) and both smoking quantity and nicotine dependence...
  45. Chen X, Chen J, Williamson V, An S, Hettema J, Aggen S, et al. Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:926-33 pubmed publisher
    ..In this study, seven single nucleotide polymorphisms were genotyped in the CHRNA5 and CHRNA3 genes. In both samples, we found that the same alleles of rs16969968 (P = 0.0068 and 0.0028) and rs1051730 (P = 0...
  46. Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, Spitz M, Eisen T, et al. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res. 2009;69:6633-41 pubmed publisher
    ..08 x 10(-6)) and 10q23.31 (rs1926203; P = 1.28 x 10(-6)). These data indicate few common variants account for 1% of the excess familial risk underscoring the necessity of having additional large sample series for gene discovery. ..
  47. Jin G, Bae E, Yang E, Lee E, Lee W, Choi J, et al. A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer. J Thorac Oncol. 2012;7:808-14 pubmed publisher
    ..This study was conducted to determine the impact of a functional polymorphism in the CHRNA3 gene on chromosome 15q25 in the survival of patients with early-stage non-small-cell lung cancer (NSCLC)...
  48. Niu X, Chen Z, Shen S, Liu Y, Zhou D, Zhang J, et al. Association of the CHRNA3 locus with lung cancer risk and prognosis in Chinese Han population. J Thorac Oncol. 2010;5:658-66 pubmed publisher
    ..However, the reported risk SNPs are extremely rare in Asians. This study sought to identify other variants on CHRNA3 associated with lung cancer susceptibility and to explore whether SNPs of CHRNA3 are of prognostic factors in ..
  49. Tyrrell J, Huikari V, Christie J, Cavadino A, Bakker R, Brion M, et al. Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet. 2012;21:5344-58 pubmed publisher
  50. Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H, et al. Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry. 2008;13:368-73 pubmed publisher
    ..In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 x 10(-5))...
  51. Saccone N, Wang J, Breslau N, Johnson E, Hatsukami D, Saccone S, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009;69:6848-56 pubmed publisher
    Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25...
  52. Wang Y, Broderick P, Matakidou A, Eisen T, Houlston R. Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers. Carcinogenesis. 2010;31:234-8 pubmed publisher
    ..33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk...
  53. Kaur Knudsen D, Bojesen S, Tybjærg Hansen A, Nordestgaard B. Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study. J Clin Oncol. 2011;29:2875-82 pubmed publisher
    ..between the nicotinic acetylcholine receptor polymorphism (rs1051730) on chromosome 15q25 marking the gene cluster CHRNA3-CHRNB4-CHRNA5, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases in the general ..