Gene Symbol: CHRNA10
Description: cholinergic receptor nicotinic alpha 10 subunit
Alias: neuronal acetylcholine receptor subunit alpha-10, NACHR alpha-10, acetylcholine receptor, nicotinic, alpha 10 (neuronal), cholinergic receptor, nicotinic alpha 10, cholinergic receptor, nicotinic, alpha 10 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 10, nicotinic acetylcholine receptor subunit alpha-10
Species: human
Products:     CHRNA10

Top Publications

  1. Kimbrel N, Garrett M, Dennis M, Liu Y, Patanam I, Workgroup V, et al. Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. Psychiatry Res. 2015;229:326-31 pubmed publisher
    ..genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD)...
  2. Pérez Rubio G, Pérez Rodríguez M, Fernandez Lopez J, Ramirez Venegas A, García Colunga J, Avila Moreno F, et al. SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. Pharmacogenomics. 2016;17:1145-1158 pubmed
    ..In the first stage, a genotyping microarray that included 347 SNPs in CHRNA2-CHRNA7/CHRNA10, CHRNB2-CHRNB4 and NRXN1 genes and 37 ancestry-informative markers was used to analyze 707 samples (187 HS, 328 ..
  3. Lustig L, Peng H, Hiel H, Yamamoto T, Fuchs P. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics. 2001;73:272-83 pubmed
    ..characterization of a new member of the human nicotinic acetylcholine receptor (nAChR) subunit family, alpha10 (CHRNA10), from both inner-ear neuroepithelium and lymphoid tissue...
  4. Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, et al. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol Pharmacol. 2002;61:150-9 pubmed
    ..These data suggest that, in vivo, alpha9-containing receptors coassemble with alpha10-subunit. ..
  5. Osman A, Schrader A, Hawkes A, Akil O, Bergeron A, Lustig L, et al. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008;38:153-69 pubmed publisher
    ..Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface. ..
  6. Saccone N, Saccone S, Hinrichs A, Stitzel J, Duan W, Pergadia M, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:453-66 pubmed publisher
  7. Ehringer M, McQueen M, Hoft N, Saccone N, Stitzel J, Wang J, et al. Association of CHRN genes with "dizziness" to tobacco. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:600-609 pubmed publisher
    ..In addition, a novel finding of association between SNPs in the CHRNA10 gene reached experiment-wide empirical significance (P = 0...
  8. Rigbi A, Yakir A, Sarner Kanyas K, Pollak Y, Lerer B. Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions. Pharmacogenomics J. 2011;11:45-52 pubmed publisher
    ..This effect may be modified by a specific genetic make-up. Such individuals may be at increased risk for nicotine addiction and for greater difficulties in smoking cessation. ..
  9. Saccone N, Schwantes An T, Wang J, Grucza R, Breslau N, Hatsukami D, et al. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav. 2010;9:741-50 pubmed publisher
    ..Variants in or near CHRND-CHRNG, CHRNA7 and CHRNA10 show modest association with nicotine dependence risk in the AA sample...

More Information


  1. Peng H, Ferris R, Matthews T, Hiel H, Lopez Albaitero A, Lustig L. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. Life Sci. 2004;76:263-80 pubmed
    ..However, a lack of demonstrated response to applied acetylcholine using standard single-cell recording techniques suggests a physiology different than that seen in hair cells of the inner ear. ..
  2. Azam L, McIntosh J. Molecular basis for the differential sensitivity of rat and human ?9?10 nAChRs to ?-conotoxin RgIA. J Neurochem. 2012;122:1137-44 pubmed publisher
    ..Remarkably, although the ?9 nAChR subunit has previously been reported to provide the principal (+) binding face for binding of RgIA, Thr56 is located in the (-) complementary binding face. ..
  3. Shi J, Hattori E, Zou H, Badner J, Christian S, Gershon E, et al. No evidence for association between 19 cholinergic genes and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:715-23 pubmed
    ..We genotyped 93 single nucleotide polymorphisms (SNPs) in 19 genes (CHAT, CHRM1-5, CHRNA1-7, CHRNA9, CHRNA10, and CHRNB1-4) in two series of samples: the National Institute of Mental Health (NIMH) Genetics Initiative ..
  4. Rigbi A, Kanyas K, Yakir A, Greenbaum L, Pollak Y, Ben Asher E, et al. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. Genes Brain Behav. 2008;7:164-72 pubmed
    ..MFFT, Stroop, CPT Loading Phase, TOL) was associated with variants in CHRNA2, CHRNA4, CHRNA5, CHRNA7, CHRNA9, CHRNA10, CHRNB2 and CHRNB3. Selective attention (Stroop) was associated with CHRNA4, CHRNA5, CHRNA9 and CHRNB2...