Gene Symbol: CHRM3
Description: cholinergic receptor muscarinic 3
Alias: EGBRS, HM3, PBS, muscarinic acetylcholine receptor M3, acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Species: human
Products:     CHRM3

Top Publications

  1. Sato K, Fujii T, Watanabe Y, Yamada S, Ando T, Kazuko F, et al. Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci Lett. 1999;266:17-20 pubmed
    ..These results indicate that both neuronal-type Nc and Ms ACh receptors are present on the surface of lymphocytes. ..
  2. Marczinovits I, Kovacs L, Gyorgy A, Toth G, Dorgai L, Molnar J, et al. A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren's syndrome. J Autoimmun. 2005;24:47-54 pubmed
    ..This is the first demonstration of the antigenicity of a novel peptide fragment of the human m3AChR in pSS. The analysed peptide could be of diagnostic relevance. ..
  3. Weber S, Thiele H, Mir S, Toliat M, Sozeri B, Reutter H, et al. Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. Am J Hum Genet. 2011;89:668-74 pubmed publisher
    ..We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44) homozygous frameshift mutation in familial congenital bladder malformation ..
  4. Ndoye A, Buchli R, Greenberg B, Nguyen V, Zia S, Rodriguez J, et al. Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J Invest Dermatol. 1998;111:410-6 pubmed
    ..Hence, a single cytotransmitter, acetylcholine, and muscarinic drugs may exert different biologic effects on keratinocytes at different stages of their maturation. ..
  5. Budd D, McDonald J, Emsley N, Cain K, Tobin A. The C-terminal tail of the M3-muscarinic receptor possesses anti-apoptotic properties. J Biol Chem. 2003;278:19565-73 pubmed
    ..We conclude that the conserved poly-basic region in the C-terminal tail of the M1, M3, and M5 receptors contributes to the ability of these receptors to mediate protection against apoptotic cell death. ..
  6. Tsuboi H, Nakamura Y, Iizuka M, Matsuo N, Matsumoto I, Sumida T. Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor. Mod Rheumatol. 2012;22:264-71 pubmed publisher
  7. Xu Z, Devillier P, Xu G, Qi H, Zhu L, Zhou W, et al. TNF-?-induced CXCL8 production by A549 cells: involvement of the non-neuronal cholinergic system. Pharmacol Res. 2013;68:16-23 pubmed publisher
    ..Our findings suggest that MR antagonists may have anti-inflammatory effects by preventing pro-inflammatory events driven by endogenous, non-neuronal ACh. ..
  8. Kagawa H, Coyan G, Davis K, Kilic A, Hickey G, Kormos R, et al. Severe Dizziness and Syncope After HeartMate 3 Implantation Requiring Pump Exchange. Ann Thorac Surg. 2019;: pubmed publisher
    Implantation of the Heartmate 3 (HM3) left ventricular assist device has continued to increase as the results of European and United States clinical trials become available...
  9. Uwada J, Yazawa T, Islam M, Khan M, Krug S, Fromm M, et al. Activation of muscarinic receptors prevents TNF-?-mediated intestinal epithelial barrier disruption through p38 MAPK. Cell Signal. 2017;35:188-196 pubmed publisher
    ..These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-? signalling and activation of EGFR. ..

More Information

Publications211 found, 100 shown here

  1. Suarez Pierre A, Lui C, Zhou X, Crawford T, Fraser C, Giuliano K, et al. Early Outcomes Following Heart Transplantation in Recipients Bridged with a HeartMate 3 Device. Ann Thorac Surg. 2019;: pubmed publisher
    ..The HeartMate 3 (HM3) is the latest device to obtain FDA-approval as BTT...
  2. Kappel K, Miao Y, McCammon J. Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor. Q Rev Biophys. 2015;48:479-87 pubmed publisher
    ..proposed to simulate processes of ligand binding to a G-protein-coupled receptor (GPCR), in this case the M3 muscarinic receptor, which is a target for treating many human diseases, including cancer, diabetes and obesity...
  3. Zhang M, Wan Y, Jin Y, Xin J, Zhang J, Xiong X, et al. Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression. PLoS ONE. 2014;9:e112350 pubmed publisher
    ..Cigarette smoking may contribute to this imbalance by affecting the polarization and survival of Th/Tregs through the up-regulation of MR3 and MR5. ..
  4. Shi T, Sun J, Wu X, Weng J, Wang P, Qie H, et al. Transcriptome analysis of Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit treated with heat and 1-MCP. Plant Physiol Biochem. 2018;133:40-49 pubmed publisher
    ..Samples of fruit were collected every three days, at 3, 6, 9, 12 and 15 d (CK3, CK6, CK9, CK12 and CK15; and HM3, HM6, HM9, HM12, and HM15, respectively)...
  5. Chung W, Park H, Heo D, Kim K, Lee M, Kim J. WNK4 kinase negatively regulates the surface expression of muscarinic M3 receptor. Cell Signal. 2011;23:566-71 pubmed publisher
    ..Nevertheless, the rate of decrease in surface M?R always exceeded that of total M?R. Taken together, these results suggest that WNK4 kinase negatively regulates the anterograde trafficking of M?R through kinase-independent mechanism. ..
  6. Bi X, He X, Xu M, Zhao M, Yu X, Lu X, et al. Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling. Cell Cycle. 2015;14:2461-72 pubmed publisher
  7. Uriel N, Medvedofsky D, Imamura T, Maly J, Kruse E, Ivák P, et al. Echocardiographic Changes in Patients Implanted With a Fully Magnetically Levitated Left Ventricular Assist Device (Heartmate 3). J Card Fail. 2019;25:36-43 pubmed publisher
    The Heartmate 3 (HM3) is a Conformiteé Européenne mark-approved left ventricular (LV) assist device (LVAD) with fully magnetically levitated rotor and features consisting of a wide range operational speeds, wide flow paths, and ..
  8. Alvarez Curto E, Ward R, Pediani J, Milligan G. Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET. J Biol Chem. 2010;285:23318-30 pubmed publisher
    ..However, conclusions as to the effect of ligands on such complexes may depend on the approach used. ..
  9. Handa R, Evan A, Connors B, Johnson C, Liu Z, Alloosh M, et al. Shock wave lithotripsy targeting of the kidney and pancreas does not increase the severity of metabolic syndrome in a porcine model. J Urol. 2014;192:1257-65 pubmed publisher
    ..the pigs were treated with 2,000 or 4,000 shock waves (24 kV at 120 shock waves per minute) using an unmodified HM3 lithotripter (Dornier MedTech, Kennesaw, Georgia)...
  10. Said A, Hu S, Abutaleb A, Watkins T, Cheng K, Chahdi A, et al. Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J. 2017;474:647-665 pubmed publisher
    b>M3 muscarinic receptor (M3R) expression is increased in colon cancer; M3R activation stimulates colon cancer cell invasion via cross-talk with epidermal growth factor receptors (EGFR), post-EGFR activation of mitogen-activated protein ..
  11. Shi J, Hattori E, Zou H, Badner J, Christian S, Gershon E, et al. No evidence for association between 19 cholinergic genes and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:715-23 pubmed
    ..Thus, it is unlikely that these 19 cholinergic genes play a major role in the pre-disposition to BD in these pedigrees. ..
  12. Schegg V, Vogel M, Didichenko S, Stadler M, Beleznay Z, Gadola S, et al. Evidence that anti-muscarinic antibodies in Sjögren's syndrome recognise both M3R and M1R. Biologicals. 2008;36:213-22 pubmed publisher
    ..Our results also suggest that neither the linear M3R peptide nor M3R transfectants represent suitable tools for discrimination of pathogenic from natural autoantibodies in SS. ..
  13. Agha Hosseini F, Mirzaii Dizgah I, Mohammadpour N. Muscarinic cholinergic receptors (MR3) in saliva of patients with oral lichen planus. Arch Dermatol Res. 2016;308:481-6 pubmed publisher
    ..Salivary M3 muscarinic receptor seems to be low in the patients with OLP and these patients suffer from xerostomia and reduced salivary ..
  14. Mahoney C, Agostinelli L, Brooks J, Lowell B, Scammell T. GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017;37:3995-4006 pubmed publisher
    ..the CeA of orexin knock-out mice crossed with vGAT-Cre mice, resulting in selective expression of the excitatory hM3 receptor or the inhibitory hM4 receptor in GABAergic neurons of the CeA...
  15. Jakubik J, Randáková A, Dolezal V. On homology modeling of the M₂ muscarinic acetylcholine receptor subtype. J Comput Aided Mol Des. 2013;27:525-38 pubmed publisher
    ..The best models were obtained using single template of the closest published structure, the M3 muscarinic receptor (PDB:4DAJ). Adding more (structurally distant) templates led to worse models...
  16. Uriel N, Adatya S, Maly J, Kruse E, Rodgers D, Heatley G, et al. Clinical hemodynamic evaluation of patients implanted with a fully magnetically levitated left ventricular assist device (HeartMate 3). J Heart Lung Transplant. 2017;36:28-35 pubmed publisher
    The HeartMate 3 (HM3) is a Conformiteé Européenne (CE) mark-approved left ventricular assist device (LVAD) with a fully magnetically levitated rotor with features consisting of a wide range of operational speeds, wide flow paths and an ..
  17. Kauschke V, Schneider M, Jauch A, Schumacher M, Kampschulte M, Rohnke M, et al. Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model. Int J Mol Sci. 2018;19: pubmed publisher
    ..Therefore, osteoporotic muscarinic acetylcholine receptor M3 (M3 mAChR) knockout (KO) and corresponding wild type (WT) mice underwent osteotomy in the distal ..
  18. Song S, Mao X, Wang C, Han A, Yan M, Xue X. LGR5/GPR49 is implicated in motor neuron specification in nervous system. Neurosci Lett. 2015;584:135-40 pubmed publisher
    ..Furthermore, knockdown of LGR5 inhibited the expression of neuronal markers MAP2, NeuN, GAP43, SYP and CHRM3, and also reduced the expression of genes that program the identity of motor neurons, including Isl1, Lhx3, PHOX2A,..
  19. Yang T, He W, Cui F, Xia J, Zhou R, Wu Z, et al. MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells. Oncotarget. 2016;7:18085-94 pubmed publisher
    The neurotransmitter acetylcholine (ACh) promotes the growth and metastasis of several cancers via its M3 muscarinic receptor (M3R)...
  20. Roepke T, Yang J, Yasrebi A, Mamounis K, Oruç E, Zama A, et al. Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats. Reprod Toxicol. 2016;62:18-26 pubmed publisher
    ..Vaginal opening, body weights, and ARC gene expression were measured. Chrm3 (muscarinic receptor 3) and Adipor1 (adiponectin receptor 1) were decreased by BPA...
  21. Iverson H, Fox D, Nadler L, Klevit R, Nathanson N. Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. J Biol Chem. 2005;280:24568-75 pubmed
    ..Solution structures show that Glu(276) resides in a type IV beta-turn and the dihydrophobic sequence Phe(280)Val(281) adopts either a type I or IV beta-turn. ..
  22. Steffens M, Leu C, Ruppert A, Zara F, Striano P, Robbiano A, et al. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol Genet. 2012;21:5359-72 pubmed publisher
    ..The associated regions harbor high-ranking candidate genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32...
  23. Cherubini E, Esposito M, Scozzi D, Terzo F, Osman G, Mariotta S, et al. Genetic Polymorphism of CHRM2 in COPD: Clinical Significance and Therapeutic Implications. J Cell Physiol. 2016;231:1745-51 pubmed publisher
    ..COPD and 17 healthy smokers were recruited and screened for ADRb2 (T164I and R175R), for CHRM2 (rs1824024) and for CHRM3 (-513C/A and -492C/T)...
  24. Heck R, Fagundes M, Cichoski A, de Menezes C, Barin J, Lorenzo J, et al. Volatile compounds and sensory profile of burgers with 50% fat replacement by microparticles of chia oil enriched with rosemary. Meat Sci. 2019;148:164-170 pubmed publisher
    ..CO); HM1 (10% PBF + 10% CO microparticles); HM2 (10% PBF + 10% CO microparticles enriched by UAE) and HM3 (10% PBF + 10% CO microparticles enriched by CME)...
  25. Montalto A, Piazza V, Albi F, Gherli R, Contento C, Palermo A, et al. Pump Speed Optimization in Patients Implanted With the HeartMate 3 Device. Transplant Proc. 2019;51:206-209 pubmed publisher
    ..Eighteen patients implanted with a HeartMate 3 (HM3) device underwent ramp tests with right heart catheterization (including central venous pressure [CVP], pulmonary ..
  26. Kamiya K, Sakabe J, Yamaguchi H, Suzuki T, Yatagai T, Aoshima M, et al. Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis. PLoS ONE. 2015;10:e0125082 pubmed publisher
    ..underlying the decreased eccrine sweating in AD patients, we examined the expression of cholinergic receptor M3 (CHRM3), a receptor for acetylcholine-induced sweating, in eccrine sweat glands...
  27. Fedoce A, Ferreira Junior N, Reis D, Corrêa F, Resstel L. M3 muscarinic receptor in the ventral medial prefrontal cortex modulating the expression of contextual fear conditioning in rats. Psychopharmacology (Berl). 2016;233:267-80 pubmed publisher
    ..1-1 nmol) or FG7142 (8 mg/Kg) increased CER expression, an effect inhibited by the low dose of the J10129 fumarate. These results indicated that the blockade of M3 muscarinic receptor in the vMPFC attenuates the CER expression.
  28. Sandiford S, Slepak V. The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7. Biochemistry. 2009;48:2282-9 pubmed publisher
    ..These results identify a novel molecular mechanism that can impart receptor subtype selectivity on signal transduction via Gq-coupled muscarinic receptors. ..
  29. Ao M, Domingue J, Khan N, Javed F, Osmani K, Sarathy J, et al. Lithocholic acid attenuates cAMP-dependent Cl- secretion in human colonic epithelial T84 cells. Am J Physiol Cell Physiol. 2016;310:C1010-23 pubmed publisher
    ..LCA action does not appear to involve known BA receptors, farnesoid X receptor, vitamin D receptor, muscarinic acetylcholine receptor M3, or bile acid-specific transmembrane G protein-coupled receptor 5...
  30. Cheng K, Shang A, Drachenberg C, Zhan M, Raufman J. Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis. Oncotarget. 2017;8:21106-21114 pubmed publisher
    b>M3 muscarinic receptor (M3R) activation promotes colon cancer cell proliferation, migration, and invasion in vitro...
  31. Crespo P, Xu N, Daniotti J, Troppmair J, Rapp U, Gutkind J. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J Biol Chem. 1994;269:21103-9 pubmed
    ..Thus, our findings implicate Raf-1 activation in transformation by G protein-coupled receptors. In addition, our data suggest that activation of p72Raf-1 and ERK2 by G protein-coupled receptors involves PKC-independent pathways. ..
  32. Wang Y, Pearce M, Sliter D, Olzmann J, Christianson J, Kopito R, et al. SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells. Biochim Biophys Acta. 2009;1793:1710-8 pubmed publisher
    ..Overall, these studies show that m3 receptor-expressing HeLa cells are a valuable system for studying IP(3) receptor ERAD, and suggest that the SPFH1/2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors. ..
  33. Kong K, Butcher A, McWilliams P, Jones D, Wess J, Hamdan F, et al. M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A. 2010;107:21181-6 pubmed publisher
  34. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, et al. Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt. Clin Cancer Res. 2015;21:4676-85 pubmed publisher
    ..We found the expression of choline acetyltransferase (ChAT), the secretion of acetylcholine and the expression of CHRM3 in prostate epithelial cells, supporting the presence of autocrine cholinergic signaling in the prostate ..
  35. Matucci R, Nesi M, Martino M, Bellucci C, Manetti D, Ciuti E, et al. Carbachol dimers as homobivalent modulators of muscarinic receptors. Biochem Pharmacol. 2016;108:90-101 pubmed publisher
    ..Functional experiments on guinea-pig ileum and assessment of ERK1/2 phosphorylation on hM1, hM2 and hM3 on CHO cells have shown that the new compounds are endowed with muscarinic antagonistic properties...
  36. McLean L, Smith A, Cheung L, Urban J, Sun R, Grinchuk V, et al. Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines. Am J Physiol Gastrointest Liver Physiol. 2016;311:G130-41 pubmed publisher
    ..Uninfected and Nippostrongylus brasiliensis-infected wild-type and type 3 muscarinic receptor (M3R)-deficient (Chrm3(-/-)) mice were studied to determine the contribution of M3R to mucosal homeostasis as well as host defense ..
  37. Hanke J, Dogan G, Rojas S, Zoch A, Feldmann C, Deniz E, et al. First experiences with HeartMate 3 follow-up and adverse events. J Thorac Cardiovasc Surg. 2017;154:173-178 pubmed publisher
    The novel HeartMate 3 (HM3) left ventricular assist device (LVAD) received its CE mark in October 2015. It is a new compact LVAD featuring fully magnetically levitated pump, artificial pulse, large pump gaps, and a modular driveline...
  38. Leroux A, Beretvas S. Estimation of a Latent Variable Regression Growth Curve Model for Individuals Cross-Classified by Clusters. Multivariate Behav Res. 2018;53:231-246 pubmed publisher
    ..latent variable regression (CCMM-LVR) model is a recent extension to the three-level latent variable regression (HM3-LVR) model which can be utilized for longitudinal data that contains individuals who changed clusters over time (..
  39. Hanke J, Dogan G, Zoch A, Ricklefs M, Wert L, Feldmann C, et al. One-year outcomes with the HeartMate 3 left ventricular assist device. J Thorac Cardiovasc Surg. 2018;156:662-669 pubmed publisher
    The HeartMate 3 (HM3; Abbott Laboratories, Lake Forest, Ill) left ventricular assist device (LVAD) received its Conformité Européenne mark for Europe in October 2015 and is currently under investigation of the Food and Drug ..
  40. Sawada Y, Nakamura M, Bito T, Fukamachi S, Kabashima R, Sugita K, et al. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. J Invest Dermatol. 2010;130:2683-6 pubmed publisher
  41. Qin K, Dong C, Wu G, Lambert N. Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers. Nat Chem Biol. 2011;7:740-7 pubmed publisher
    ..That other G(q)-coupled receptors possess similar polybasic regions and also preassemble with G(q) suggests that these GPCRs may use a common preassembly mechanism to facilitate activation of G(q) heterotrimers. ..
  42. Jiang Y, Lee C, Kuo H. Urothelial Dysfunction, Suburothelial Inflammation and Altered Sensory Protein Expression in Men with Bladder Outlet Obstruction and Various Bladder Dysfunctions: Correlation with Urodynamics. J Urol. 2016;196:831-7 pubmed publisher
    ..Additionally, higher expression of P2X3 and M2 muscarinic receptors, and lower expression of M3 muscarinic receptor were detected in study patients...
  43. Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed publisher
    ..Moreover, we found that M3 cholinergic receptor (CHRM3) was upregulated in a large subset of benign prostatic hyperplasia (BPH) tissues compared with normal tissues...
  44. Klenke S, de Vries G, Schiefer L, Seyffert N, Bachmann H, Peters J, et al. CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective. Br J Anaesth. 2018;121:58-65 pubmed publisher
    ..PONV risk associates with specific M3 muscarinic acetylcholine receptor (CHRM3) rs 2165870 polymorphism...
  45. Budd D, McDonald J, Tobin A. Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha. J Biol Chem. 2000;275:19667-75 pubmed
  46. Song W, Yuan M, Zhao S. Variation of M3 muscarinic receptor expression in different prostate tissues and its significance. Saudi Med J. 2009;30:1010-6 pubmed
    ..0001). The M3 receptor and VEGF showed positive straight-line correlations of gene expressions with the 3 groups (r=0.4999, p=0.0001). The M3 receptor may have a close relationship with prostatic oncogenesis. ..
  47. Greenwood J, Dragunow M. M3 muscarinic receptors promote cell survival through activation of the extracellular regulated kinase (ERK1/2) pathway. Eur J Pharmacol. 2010;640:38-45 pubmed publisher
    ..Understanding such survival signalling pathways is important for both potential interventions in neurodegenerative disease and for targeting neuroblastoma and malignancies of the central nervous system. ..
  48. He J, Qiang L, Ding Y, Wei P, Li Y, Hua H, et al. The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP205-220) antibody in the saliva of patients with primary Sjögren's syndrome. Clin Exp Rheumatol. 2012;30:322-6 pubmed
    ..The presence of the antibody was closely associated with the salivary flow rate. This indicated that it may act as an autoantigen, with a role in the pathogenesis of pSS. ..
  49. Kalantari Dehaghi M, Anhalt G, Camilleri M, Chernyavsky A, Chun S, Felgner P, et al. Pemphigus vulgaris autoantibody profiling by proteomic technique. PLoS ONE. 2013;8:e57587 pubmed publisher
    ..antigens recognized by the majority of test patients' sera were proteins encoded by the DSC1, DSC3, ATP2C1, PKP3, CHRM3, COL21A1, ANXA8L1, CD88 and CHRNE genes...
  50. Kan W, Adjobo Hermans M, Burroughs M, Faibis G, Malik S, Tall G, et al. M3 muscarinic receptor interaction with phospholipase C ?3 determines its signaling efficiency. J Biol Chem. 2014;289:11206-18 pubmed publisher
    ..Here we report evidence for a direct interaction between M3 muscarinic receptor (M3R) and PLC?3...
  51. Sciolino N, Plummer N, Chen Y, Alexander G, Robertson S, Dudek S, et al. Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types. Cell Rep. 2016;15:2563-73 pubmed publisher
    Chemogenetic technologies, including the mutated human Gq-coupled M3 muscarinic receptor (hM3Dq), have greatly facilitated our ability to directly link changes in cellular activity to altered physiology and behavior...
  52. Jeong I, Lim J, Oh D, Kim W, Oh Y. Gene expression profile of human lung in a relatively early stage of COPD with emphysema. Int J Chron Obstruct Pulmon Dis. 2018;13:2643-2655 pubmed publisher
    ..In the COPD without emphysema group, the CHRM3 gene, previously reported to be associated with COPD, and HDAC10 were markedly increased and decreased, ..
  53. Nagaraju K, Cox A, Casciola Rosen L, Rosen A. Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death. Arthritis Rheum. 2001;44:2376-86 pubmed
    ..The data focus attention on the role of cytotoxic lymphocytes in the initiation and propagation of Sjögren's syndrome. ..
  54. Fisher J, Vincent S, Gomeza J, Yamada M, Wess J. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J. 2004;18:711-3 pubmed
  55. Slack B, Blusztajn J. Differential regulation of mTOR-dependent S6 phosphorylation by muscarinic acetylcholine receptor subtypes. J Cell Biochem. 2008;104:1818-31 pubmed publisher
    ..The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner. ..
  56. Ekman M, Rippe C, Sadegh M, Dabestani S, Morgelin M, Uvelius B, et al. Association of muscarinic M? receptors and Kir6.1 with caveolae in human detrusor muscle. Eur J Pharmacol. 2012;683:238-45 pubmed publisher
    ..In conclusion, pharmacological K(ATP) channel inhibition antagonizes the effect of caveolae disruption on muscarinic contractility in the human detrusor, and the K(ATP) channel subunit Kir6.1 co-localizes with M? receptors in caveolae...
  57. Kajiya M, Ichimonji I, Min C, Zhu T, Jin J, Yu Q, et al. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. Mol Pharmacol. 2012;82:115-24 pubmed publisher
    ..This study, for the first time, proposes that CCh-mediated M3R activation can promote not only fluid secretion but also survival of salivary gland cells in the inflammatory context of SjS. ..
  58. Arrighi N, Bodei S, Zani D, Simeone C, Cunico S, Spano P, et al. [Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization]. Urologia. 2012;79:102-8 pubmed publisher
    ..These results could help to better understand the role of antimuscarinic drugs, which are currently used for the treatment of many urological diseases...
  59. Xu Z, Song Y, Yang K, Zhou W, Hou L, Zhu L, et al. M3 mAChR-mediated IL-8 expression through PKC/NF-κB signaling pathways. Inflamm Res. 2014;63:463-73 pubmed publisher
  60. Al Zobaidy M, Martin W. The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus. Eur J Pharmacol. 2014;741:171-7 pubmed publisher
    ..of L-NMMA or ADMA were also examined on relaxation to acetylcholine when its apparent efficacy at the M3 muscarinic receptor was reduced using the irreversible receptor blocking agent, phenoxybenzamine...
  61. Zhang J, Loh K, Lee J, Wang C, Dai Y, Wah Tong Y. Three-stage anaerobic co-digestion of food waste and horse manure. Sci Rep. 2017;7:1269 pubmed publisher
    A novel compact three-stage anaerobic digester (HM3) was developed to combine the advantages of high solids anaerobic digestion (AD) and wet AD for co-digestion of food waste and horse manure...
  62. Barbosa J, Reis S, Nunes M, Ferreira Y, Leite K, Nahas W, et al. The Obstructed Bladder: Expression of Collagen, Matrix Metalloproteinases, Muscarinic Receptors, and Angiogenic and Neurotrophic Factors in Patients With Benign Prostatic Hyperplasia. Urology. 2017;106:167-172 pubmed publisher
    ..TIMPs) TIMP-1, TIMP-2, and reversion-inducing cysteine-rich protein with kazal motifs (RECK); CHRM2 and CHRM3; VEGF and CD105; and NGF and nerve growth factor receptor (NGFr)...
  63. Swayne L, Mezghrani A, Varrault A, Chemin J, Bertrand G, Dalle S, et al. The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep. 2009;10:873-80 pubmed publisher
    ..Taken together, our data show the molecular basis of a muscarinic-activated inward sodium current that is independent of G-protein activation, and provide new insights into the properties of NALCN channels. ..
  64. Wu J, Zhou J, Yao L, Lang Y, Liang Y, Chen L, et al. High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer. Tumour Biol. 2013;34:3939-44 pubmed publisher
    ..High M3 receptor expression correlates with poor survival in NSCLC patients. M3 receptor expression may be related with tumor progression in NSCLC, indicating that M3 receptor may be a novel antineoplastic target in the future. ..
  65. Patten G, Kerr C, Dunne R, Shaw J, Bird A, Regina A, et al. Resistant starch alters colonic contractility and expression of related genes in rats fed a Western diet. Dig Dis Sci. 2015;60:1624-32 pubmed publisher
    ..05). The colonic expression of genes, including cholinergic receptors (Chrm2, Chrm3), serotonin receptors (Htr5a, Htr7), a protease-activated receptor (F2r), a prokineticin receptor (Prokr1), ..
  66. Luukkonen T, Mehrjouy M, Poyhonen M, Anttonen A, Lahermo P, Ellonen P, et al. Breakpoint mapping and haplotype analysis of translocation t(1;12)(q43;q21.1) in two apparently independent families with vascular phenotypes. Mol Genet Genomic Med. 2018;6:56-68 pubmed publisher
    ..The chromosome 1 breakpoint truncates a CHRM3 processed transcript, and is flanked by the 5' end of CHRM3 and the 3' end of RYR2...
  67. Bschleipfer T, Schukowski K, Weidner W, Grando S, Schwantes U, Kummer W, et al. Expression and distribution of cholinergic receptors in the human urothelium. Life Sci. 2007;80:2303-7 pubmed
    ..In view of the multiplicity of pathways to which different cholinergic receptor subtypes are coupled, we propose that this layer-specific distribution serves to stratify cholinergic regulation of human urothelial function. ..
  68. Appel S, Le Hellard S, Bruland O, Brun J, Omdal R, Kristjansdottir G, et al. Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome. Ann Rheum Dis. 2011;70:1327-9 pubmed publisher
    ..Specifically, dysfunction of exocrine pathways involving the muscarinic receptor 3 (CHRM3) has been indicated. To investigate possible genetic divergence in the CHRM3 gene in patients with pSS...
  69. Borroto Escuela D, Romero Fernandez W, García Negredo G, Correia P, Garriga P, Fuxe K, et al. Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation. Cell Physiol Biochem. 2011;28:1009-22 pubmed publisher
    ..Overall, these results indicate that the NPxxY motif of the M(3) muscarinic acetylcholine receptor acts as key conformational switch for receptor signaling and multiprotein complex formation. ..
  70. Bradley S, Wiegman C, Iglesias M, Kong K, Butcher A, Plouffe B, et al. Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction. Proc Natl Acad Sci U S A. 2016;113:4524-9 pubmed publisher
    ..In this way, we present an approach by which to predict the physiological/therapeutic outcome of M3-mAChR-biased ligands with important implications for drug discovery. ..
  71. Yu X, Riemekasten G, Petersen F. Autoantibodies against muscarinic acetylcholine receptor M3 in Sjogren's syndrome and corresponding mouse models. Front Biosci (Landmark Ed). 2018;23:2053-2064 pubmed
    ..Based on these comprehensive data, we propose a hypothetic model for the role of aab against M3R in the pathogenesis of SS. ..
  72. Lips K, Kneffel M, Willscheid F, Mathies F, Kampschulte M, Hartmann S, et al. Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice. Int Immunopharmacol. 2015;29:201-7 pubmed publisher
    ..Bone loss has already been determined in male mice with gene deficiency of muscarinic acetylcholine receptor M3 (M3R-KO)...
  73. Basalay M, Mastitskaya S, Mrochek A, Ackland G, del Arroyo A, Sanchez J, et al. Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning. Cardiovasc Res. 2016;112:669-676 pubmed GLP-1R agonist Exendin-4 was preserved following cervical vagotomy, but was abolished in conditions of M3 muscarinic receptor blockade...
  74. Li S, Villeneuve D, Berninger J, Blackwell B, Cavallin J, Hughes M, et al. An integrated approach for identifying priority contaminant in the Great Lakes Basin - Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern. Sci Total Environ. 2017;579:825-837 pubmed publisher diethylphthalate and naphthalene, and genes and related pathways, such as cholinergic receptor muscarinic 3 (CHRM3), estrogen receptor alpha1 (esr1), chemokine ligand 10 protein (CXCL10), tumor protein p53 (p53), and monoamine ..
  75. Heinzman J, Hoth K, Cho M, Sakornsakolpat P, Regan E, Make B, et al. GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort. J Affect Disord. 2019;243:16-22 pubmed publisher
    ..One of the top SNPs, rs12036147 (p = 1.28 × 10-6), is near CHRM3. Another SNP was near MDGA2 (rs17118176, p = 3.52 × 10-6)...
  76. Harrington A, Peck C, Liu L, Burcher E, Hutson J, Southwell B. Localization of muscarinic receptors M1R, M2R and M3R in the human colon. Neurogastroenterol Motil. 2010;22:999-1008, e262-3 pubmed publisher
    ..The cellular distribution for MRs found in this study agrees with data from functional studies, providing insight into the role MRs have in mediating enteric cholinergic neurotransmission. ..
  77. Peralta E, Ashkenazi A, Winslow J, Smith D, Ramachandran J, Capon D. Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987;6:3923-9 pubmed
    ..the human M1 and M2 muscarinic receptors (mAChR) as well as two previously undiscovered mAChR subtypes, designated HM3 and HM4...
  78. Haga K, Kameyama K, Haga T, Kikkawa U, Shiozaki K, Uchiyama H. Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C. J Biol Chem. 1996;271:2776-82 pubmed
  79. Mehra M, Salerno C, Cleveland J, Pinney S, Yuzefpolskaya M, Milano C, et al. Health Care Resource Use and Cost Implications in the MOMENTUM 3 Long-Term Outcome Study: A Randomized Controlled Trial of a Magnetically Levitated Cardiac Pump in Advanced Heart Failure. Circulation. 2018;: pubmed publisher
    b>Background : MOMENTUM 3 compares the centrifugal HeartMate 3 (HM3) to the axial HeartMate II (HMII) continuous-flow Left Ventricular Assist System (LVAS) in patients with advanced heart failure, irrespective of the intended ..
  80. Mahati E, Li P, Kurata Y, Maharani N, Ikeda N, Sakata S, et al. M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells. Circ J. 2016;80:2443-2452 pubmed
    ..Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2. (Circ J 2016; 80: 2443-2452). ..
  81. Wang C, Chen T, Mei C, Chang C, Liu L, Chiu K, et al. The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City. Biomed Res Int. 2016;2016:4052846 pubmed publisher
    ..b>Muscarinic acetylcholine receptor M3 (CHRM3) was reported as a key receptor in different cancer types...
  82. Darby M, Schnoeller C, Vira A, Culley F, Culley F, Bobat S, et al. The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. PLoS Pathog. 2015;11:e1004636 pubmed publisher
    ..Our data therefore indicate that cholinergic signalling via the M3R is essential for optimal Th1 and Th2 adaptive immunity to infection. ..
  83. Ikarashi R, Akechi H, Kanda Y, Ahmad A, Takeuchi K, Morioka E, et al. Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells. Sci Rep. 2017;7:44175 pubmed publisher
    ..This is consistent with significant M3 muscarinic receptor expression and little photo-sensor (Cry2 and Opn4) expression in these cells...
  84. Chen X, Bai Y, Sun H, Su Z, Guo J, Sun C, et al. Overexpression of M3 Muscarinic Receptor Suppressed Adverse Electrical Remodeling in Hypertrophic Myocardium Via Increasing Repolarizing K+ Currents. Cell Physiol Biochem. 2017;43:915-925 pubmed publisher
    ..1 in ventricular myocytes. M3-mAChR overexpression protected against adverse electrical remodeling in CH by enhancing potassium currents and promoting repolarization. ..
  85. Lugea A, Waldron R, Mareninova O, Shalbueva N, Deng N, Su H, et al. Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis. Am J Pathol. 2017;187:2726-2743 pubmed publisher
    ..Human acini preferentially expressed the muscarinic acetylcholine receptor M3 and maintained physiological responses to CCh for at least 20 hours...
  86. Szekeres P, Koenig J, Edwardson J. The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line. Mol Pharmacol. 1998;53:759-65 pubmed
    ..An important implication of this analysis is that extremely weak partial agonists (which may in practice be indistinguishable from antagonists) may produce significant receptor internalization. ..
  87. Thorsen T, Matt R, Weis W, Kobilka B. Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure. 2014;22:1657-64 pubmed publisher
    ..These variants were tested on the M3 muscarinic receptor (M3). The original M3-T4L fusion protein produced twinned crystals that yielded a 3...
  88. Niwa Y, Kanda G, Yamada R, Shi S, Sunagawa G, Ukai Tadenuma M, et al. Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep. Cell Rep. 2018;24:2231-2247.e7 pubmed publisher
    ..that a similar short-sleep phenotype appears in the knockout of two Gq-type acetylcholine receptors Chrm1 and Chrm3. Strikingly, Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level...
  89. Tovey S, Willars G. Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor. Mol Pharmacol. 2004;66:1453-64 pubmed
    ..Despite little or no effect on responses to maximal receptor activation, RGS4 produced effects on the magnitude, kinetics, and oscillatory behavior of Ca2+ signaling at submaximal levels that were consistent with those of RGS2 and -3. ..
  90. Hur K, Cejas P, Feliu J, Moreno Rubio J, Burgos E, Boland C, et al. Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut. 2014;63:635-46 pubmed publisher
    ..LINE-1 methylation levels were determined by quantitative bisulfite pyrosequencing. MET, RAB3IP and CHRM3 protein expression was determined by western blotting and IHC...
  91. Darby W, Potocnik S, Ramachandran R, Hollenberg M, Woodman O, McIntyre P. Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation. Pharmacol Res. 2018;133:152-159 pubmed publisher
    ..Finally, agonist activation of the M3 muscarinic receptor opened TRPV4 in HEK293 cells...