Gene Symbol: CHRM1
Description: cholinergic receptor muscarinic 1
Alias: HM1, M1R, muscarinic acetylcholine receptor M1, acetylcholine receptor, muscarinic 1
Species: human
Products:     CHRM1

Top Publications

  1. Mancama D, Arranz M, Landau S, Kerwin R. Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;119B:2-6 pubmed
    ..These results provide evidence in support of altered muscarinic 1 receptor expression in schizophrenia, though further work is needed to corroborate these findings. ..
  2. Peralta E, Ashkenazi A, Winslow J, Smith D, Ramachandran J, Capon D. Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987;6:3923-9 pubmed
    ..Subtype-specific mRNA expression was observed in the heart, pancreas and a neuronal cell line, indicating that the regulation of mAChR gene expression contributes to the differentiation of cholinergic activity. ..
  3. Christopoulos A, Pierce T, Sorman J, El Fakahany E. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor. Mol Pharmacol. 1998;53:1120-30 pubmed
  4. Lucas J, DeYoung J, Sadee W. Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene. AAPS PharmSci. 2001;3:E31 pubmed
    The gene encoding the human muscarinic receptor, type 1 (CHRM1), was genotyped from 245 samples of the Coriell Collection (Coriell Institute for Medical Research, Camden, NJ)...
  5. Dean B, McLeod M, Keriakous D, McKenzie J, Scarr E. Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry. 2002;7:1083-91 pubmed
    ..the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 ..
  6. Scarr E, Cowie T, Kanellakis S, Sundram S, Pantelis C, Dean B. Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Mol Psychiatry. 2009;14:1017-23 pubmed publisher
    ..We have established that the CHRM1 is selectively decreased in the dorsolateral prefrontal cortex of subjects with schizophrenia...
  7. Marquer C, Fruchart Gaillard C, Letellier G, Marcon E, Mourier G, Zinn Justin S, et al. Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor. J Biol Chem. 2011;286:31661-75 pubmed publisher
    The snake toxin MT7 is a potent and specific allosteric modulator of the human M1 muscarinic receptor (hM1)...
  8. Kienitz M, Vladimirova D, Muller C, Pott L, Rinne A. Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors. J Biol Chem. 2016;291:26410-26426 pubmed
  9. Lee A, Yang Q, Bassyouni A, Butler C, Hou X, Jenkinson S, et al. Ligand biological activity predicted by cleaning positive and negative chemical correlations. Proc Natl Acad Sci U S A. 2019;116:3373-3378 pubmed publisher
    ..We prospectively apply our model to the human muscarinic acetylcholine receptor M1, finding four experimentally confirmed agonists that are chemically dissimilar to all known ligands...

More Information

Publications153 found, 100 shown here

  1. Sawyer G, Ehlert F, Shults C. Cysteine pairs in the third intracellular loop of the muscarinic m1 acetylcholine receptor play a role in agonist-induced internalization. J Pharmacol Exp Ther. 2008;324:196-205 pubmed
    ..Collectively, these observations suggest that Cys pairs Cys259/Cys260 and Cys262/Cys263 play an important role in the agonist-induced internalization of hM(1) receptors. ..
  2. Mullaney I, Mitchell F, McCallum J, Buckley N, Milligan G. The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively. FEBS Lett. 1993;324:241-5 pubmed
    ..Following transfection and stable expression of CHO cells with DNA encoding the human muscarinic M1 acetylcholine (HM1) receptor, chronic treatment of the cells with the cholinergic agonist carbachol resulted in down-regulation of ..
  3. Liu H, Hong C, Liu T, Chi C, Tsai S. Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Dement Geriatr Cogn Disord. 2005;19:42-5 pubmed
    ..investigation, we tested the hypothesis that the allelic variant (C267A) of the cholinergic receptor muscarinic 1 (CHRM1) confers susceptibility to AD or is related to its age of onset, in a sample population of 232 AD patients and 169 ..
  4. Gibbons A, Scarr E, Boer S, Money T, Jeon W, Felder C, et al. Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia. Int J Neuropsychopharmacol. 2013;16:37-46 pubmed publisher
    ..Our data have implications for understanding the potential clinical utility of drugs directed at the orthosteric and allosteric sites of muscarinic receptors to treat schizophrenia. ..
  5. Sauter D, Hué S, Petit S, Plantier J, Towers G, Kirchhoff F, et al. HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef. Retrovirology. 2011;8:103 pubmed publisher
    ..O or rare Group N viruses, efficiently antagonize the human orthologue of the restriction factor tetherin (BST-2, HM1.24, CD317) suggesting that primate lentiviruses may have to gain anti-tetherin activity for efficient spread in the ..
  6. Yang J, Cirico T, Katzen F, Peterson T, Kudlicki W. Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs. BMC Biotechnol. 2011;11:57 pubmed publisher
  7. Jiménez Morales S, Jiménez Ruíz J, del Rio Navarro B, Navarro Olivos E, Escamilla Guerrero G, Savan R, et al. CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients. Mol Biol Rep. 2014;41:2109-17 pubmed publisher
    ..To determine whether single nucleotide polymorphisms (SNPs) or haplotypes in CHRM1, CHRM2, or CHRM3 are associated with asthma in Mexican pediatric population...
  8. Niwa Y, Kanda G, Yamada R, Shi S, Sunagawa G, Ukai Tadenuma M, et al. Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep. Cell Rep. 2018;24:2231-2247.e7 pubmed publisher
    ..method reveals that a similar short-sleep phenotype appears in the knockout of two Gq-type acetylcholine receptors Chrm1 and Chrm3...
  9. Sharma N, Shin E, Kim N, Cho E, Jeong J, Jang C, et al. Protective potentials of far-infrared ray against neuropsychotoxic conditions. Neurochem Int. 2019;122:144-148 pubmed publisher
    ..In this mini-review, we have discussed with the protective potentials mediated by FIR against MA-induced psychotoxic burdens. ..
  10. Liao D, Hong C, Chen H, Chen Y, Lee S, Chang C, et al. Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients. Neuropsychobiology. 2003;48:72-6 pubmed
    ..This study investigated the association of type I muscarinic receptor (CHRM1) genetic polymorphisms with the clinical characteristics of chronic schizophrenic inpatients...
  11. Coccini T, Crevani A, Rossi G, Assandri F, Balottin U, Nardo R, et al. Reduced platelet monoamine oxidase type B activity and lymphocyte muscarinic receptor binding in unmedicated children with attention deficit hyperactivity disorder. Biomarkers. 2009;14:513-22 pubmed publisher
  12. Abdul Ridha A, Lopez L, Keov P, Thal D, Mistry S, Sexton P, et al. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. J Biol Chem. 2014;289:6067-79 pubmed publisher
    ..This new insight into the structural basis of binding and function of BQCA can guide the design of new allosteric ligands with tailored pharmacological properties. ..
  13. Heck R, Fagundes M, Cichoski A, de Menezes C, Barin J, Lorenzo J, et al. Volatile compounds and sensory profile of burgers with 50% fat replacement by microparticles of chia oil enriched with rosemary. Meat Sci. 2019;148:164-170 pubmed publisher
    ..5% water +2.5% unencapsulated CO); HM1 (10% PBF + 10% CO microparticles); HM2 (10% PBF + 10% CO microparticles enriched by UAE) and HM3 (10% PBF ..
  14. Ohta K, Goto H, Yumine N, Nishio M. Human parainfluenza virus type 2 V protein inhibits and antagonizes tetherin. J Gen Virol. 2016;97:561-70 pubmed publisher
    Tetherin (BST-2/CD317/HM1.24) is an antiviral membrane protein that prevents the release of enveloped viruses from the cell surface...
  15. Matucci R, Nesi M, Martino M, Bellucci C, Manetti D, Ciuti E, et al. Carbachol dimers as homobivalent modulators of muscarinic receptors. Biochem Pharmacol. 2016;108:90-101 pubmed publisher
    ..The new compounds have been tested on the five cloned muscarinic receptors (hM1-5) expressed in CHO cells by means of equilibrium binding studies, showing an increase in affinity by rising the ..
  16. Ilien B, Franchet C, Bernard P, Morisset S, Weill C, Bourguignon J, et al. Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties. J Neurochem. 2003;85:768-78 pubmed
    ..Finally, this fluorescence-based assay, prone to miniaturization, allows reliable detection of unlabelled competitors. ..
  17. Jones A, Mowry B, McLean D, Mantzioris B, Pender M, Greer J. Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia. J Neuroimmunol. 2014;269:68-75 pubmed publisher
    ..These results support the hypothesis that neurotransmitter receptors or molecules involved in regulation of neurotransmission are targets of autoantibodies in some people with schizophrenia. ..
  18. Dean B, Scarr E. Possible involvement of muscarinic receptors in psychiatric disorders: a focus on schizophrenia and mood disorders. Curr Mol Med. 2015;15:253-64 pubmed
    ..This review will focus on data suggesting changes in levels of CHRM1 and CHRM4 implicate these receptors in the pathophysiology of schizophrenia whereas data suggest a role for CHRM2 ..
  19. Ansari M, Siddiqui S, Agarwal S, Vikramdeo K, Mondal N, Azam A. Metronidazole hydrazone conjugates: Design, synthesis, antiamoebic and molecular docking studies. Bioorg Med Chem Lett. 2015;25:3545-9 pubmed publisher
    Metronidazole hydrazone conjugates (2-13) were synthesized and screened in vitro for antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Six compounds were found to be better inhibitors of E...
  20. Dean B, Scarr E. COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex. Am J Med Genet B Neuropsychiatr Genet. 2016;171:784-9 pubmed publisher
    ..and if genotype at the four COMT SNPs was related to expression of the cortical muscarinic M1 receptor (CHRM1) because the expression of the cortical CHRM1 has been reported to be lower in schizophrenia and is important in ..
  21. Zheng Y, Hao X, Zheng Q, Lin X, Zhang X, Zeng W, et al. Canine Influenza Virus is Mildly Restricted by Canine Tetherin Protein. Viruses. 2018;10: pubmed publisher
    Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells...
  22. Ishiyama A, Lopez I, Wackym P. Molecular characterization of muscarinic receptors in the human vestibular periphery. Implications for pharmacotherapy. Am J Otol. 1997;18:648-54 pubmed
    ..The pharmacologic implications of these data are discussed. ..
  23. Warren N, Piggott M, Lees A, Perry E, Burn D. Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias. J Chem Neuroanat. 2008;35:268-74 pubmed publisher
    ..We conclude from this first systematic study of cortical muscarinic receptors in PSP that functioning cortical muscarinic receptors are preserved. A further, larger trial of cholinergic therapy, such as an M1 agonist, may be warranted. ..
  24. Fichtner S, Hose D, Engelhardt M, Meißner T, Neuber B, Krasniqi F, et al. Association of antigen-specific T-cell responses with antigen expression and immunoparalysis in multiple myeloma. Clin Cancer Res. 2015;21:1712-21 pubmed publisher
    ..We assessed the expression of the multiple myeloma antigen HM1.24 (reported present in all malignant plasma cells) and the CTAs MAGE-A2/A3 and NY-ESO-1 (aberrantly expressed in a ..
  25. Cheng Y, Yu L. Galanin up-regulates the expression of M1 muscarinic acetylcholine receptor via the ERK signaling pathway in primary cultured prefrontal cortical neurons. Neurosci Lett. 2015;590:161-5 pubmed publisher
  26. Yeatman H, Lane J, Choy K, Lambert N, Sexton P, Christopoulos A, et al. Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking. J Biol Chem. 2014;289:15856-66 pubmed publisher
  27. Pierce H, Zhang D, Magnon C, Lucas D, Christin J, Huggins M, et al. Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay. Cell Stem Cell. 2017;20:648-658.e4 pubmed publisher
    ..Here we show that muscarinic receptor type-1 (Chrm1) signaling in the hypothalamus promotes G-CSF-elicited HSC mobilization via hormonal priming of the hypothalamic-..
  28. Marteau J, Samara A, Dedoussis G, Pfister M, Visvikis Siest S. Candidate gene microarray analysis in peripheral blood cells for studying hypertension/obesity. Per Med. 2009;6:269-291 pubmed publisher
    ..These genes were ALOX5, APOA2, SELL, RGS2, CD14, FPR1, CAMP, DEFA3, DEFA4, CBS, CHRM1, ICAM1, NR1H2, SCNN1B and TGFB1...
  29. Park Y, Cho N. EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012;370:191-8 pubmed publisher
    ..Together, these data indicate that EGFR and PKC are involved in mAChR-mediated activation of ERK1/2 and RSK and the subsequent proliferation of SNU-407 colon cancer cells. ..
  30. Damiano S, Petrozziello T, Ucci V, Amente S, Santillo M, Mondola P. Cu-Zn superoxide dismutase activates muscarinic acetylcholine M1 receptor pathway in neuroblastoma cells. Mol Cell Neurosci. 2013;52:31-7 pubmed publisher
    ..Collectively, the results of this study demonstrated that SOD1 could activate a transductional pathway through the involvement of M1 muscarinic receptor. ..
  31. Klausz K, Kellner C, Derer S, Valerius T, Staudinger M, Burger R, et al. The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development. J Immunol Methods. 2015;418:75-83 pubmed publisher
    ..Mouse antibodies directed against CD7 and CD317/HM1.24 that previously had been used for the generation of functional recombinant immunotoxins, also showed activity in ..
  32. Renz B, Tanaka T, Sunagawa M, Takahashi R, Jiang Z, Macchini M, et al. Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness. Cancer Discov. 2018;8:1458-1473 pubmed publisher
    ..These effects were mediated in part through CHRM1, which inhibited downstream MAPK/EGFR and PI3K/AKT pathways in PDAC cells...
  33. Salah Uddin H, Scarr E, Pavey G, Harris K, Hagan J, Dean B, et al. Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype. Neuropsychopharmacology. 2009;34:2156-66 pubmed publisher
    ..Here we have assessed whether the receptor function of the M(1) subtype (CHRM1) is altered in a sub-population of patients with schizophrenia, defined by marked (60-80%) reductions in cortical [..
  34. Michal P, El Fakahany E, Dolezal V. Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors. Neurochem Res. 2015;40:2068-77 pubmed publisher
    ..On the other hand, modifications in agonist-stimulated GTP-?(35)S binding in CHO-M3 membranes indicate that in this case changes in ligand-activated receptor/G-protein interaction may also play a role. ..
  35. Londrigan S, Tate M, Job E, Moffat J, Wakim L, Gonelli C, et al. Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection. PLoS ONE. 2015;10:e0142925 pubmed publisher
    BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 during influenza A virus infection (IAV) is controversial...
  36. Cardozo T, Shmelkov E, Felsovalyi K, Swetnam J, Butler T, Malaspina D, et al. Chemistry-based molecular signature underlying the atypia of clozapine. Transl Psychiatry. 2017;7:e1036 pubmed publisher
    ..Our results implicate dopamine D4 receptors in the pineal gland and muscarinic acetylcholine M1 (CHRM1) and M3 (CHRM3) receptors in the prefrontal cortex (PFC) as significant and unique to clozapine, whereas serotonin ..
  37. Wang J, Bian S, Liu M, Zhang X, Wang S, Bai X, et al. Cloning, identification, and functional analysis of bone marrow stromal cell antigen-2 from sika deer (Cervus nippon). Gene. 2018;661:133-138 pubmed publisher
    BST-2(tetherin/CD317/HM1.24) has been identified as a cellular antiviral factor that inhibits the release of a wide range of enveloped viruses from infected cells...
  38. Silva F, Hummel A, Jenne D, Specks U. Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen. J Autoimmun. 2010;35:299-308 pubmed publisher
    ..coated with recombinant human (H) and murine (M) PR3 and 10 custom-designed chimeric human/mouse rPR3-variants (Hm1-5/Mh1-5) identifying 5 separate non-conserved PR3 surface epitopes...
  39. Urrunaga N, Jadeja R, Rachakonda V, Ahmad D, McLean L, Cheng K, et al. M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury. Free Radic Biol Med. 2015;78:66-81 pubmed publisher
    ..Age-matched wild-type (WT) and M1R-deficient (Chrm1(-/-)) male mice were injected intraperitoneally with 200mg/kg acetaminophen (APAP) and euthanized 0, 2, 4, 16, 24, ..
  40. Bradley S, Molloy C, Bundgaard C, Mogg A, Thompson K, Dwomoh L, et al. Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes. Mol Pharmacol. 2018;93:645-656 pubmed publisher
  41. Maurya M, Uprety B, Avecilla F, Tariq S, Azam A. Palladium(II) complexes of OS donor N-(di(butyl/phenyl)carbamothioyl)benzamide and their antiamoebic activity. Eur J Med Chem. 2015;98:54-60 pubmed publisher
    ..Both the complexes and their respective ligands were screened in vitro for antiamoebic activity against HM1:1MSS strain of Entamoeba histolytica by microdilution method and cell viability in response to drugs was checked by ..
  42. Ding S, Hu J, Yang J, Liu L, Huang W, Gu X, et al. The inactivation of JAK2/STAT3 signaling and desensitization of M1 mAChR in minimal hepatic encephalopathy (MHE) and the protection of naringin against MHE. Cell Physiol Biochem. 2014;34:1933-50 pubmed publisher
    ..Our findings provide not only a novel pathological hallmark in MHE but also a novel target in MHE therapy. ..
  43. Jiang L, Kosenko A, Yu C, Huang L, Li X, Hoshi N. Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channels through a CRMP-2-mediated pathway. J Cell Sci. 2015;128:4235-45 pubmed publisher
    ..Stimulation of m1 muscarinic acetylcholine receptor (also known as CHRM1) increases neuronal excitability by suppressing the M-current generated by the Kv7/KCNQ channel family...
  44. Ohta K, Matsumoto Y, Ito M, Nishio M. Tetherin antagonism by V proteins is a common trait among the genus Rubulavirus. Med Microbiol Immunol. 2017;206:319-326 pubmed publisher
    Tetherin (BST-2/CD317/HM1.24) is an anti-viral factor that restricts the budding of several enveloped viruses. Most of these viruses have evolved to encode tetherin antagonists...
  45. Matejčeková Z, Soltészová F, Acai P, Liptáková D, Valík L. Application of Lactobacillus plantarum in Functional Products Based on Fermented Buckwheat. J Food Sci. 2018;83:1053-1062 pubmed publisher
    ..with lactic acid cocci of the Fresco DVS 1010 culture and the human-derived isolate Lactobacillus plantarum HM1. The effect of single and coculture fermentation was studied at 30 and 37 ± 0...
  46. Randáková A, Dolejší E, Rudajev V, Zimčík P, Doležal V, El Fakahany E, et al. Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms. Pharmacol Res. 2015;97:27-39 pubmed publisher
    ..Our data show that both classical and atypical agonists activate hM1 receptors by the same molecular switch that involves D71 in the second transmembrane helix...
  47. Pedretti A, Mazzolari A, Ricci C, Vistoli G. Enhancing the Reliability of GPCR Models by Accounting for Flexibility of Their Pro-Containing Helices: the Case of the Human mAChR1 Receptor. Mol Inform. 2015;34:216-27 pubmed publisher
  48. Bagde S, Singh V. Assessments of Immunomodulatory and Inflammatory effects against Induction of Entamoeba histolytica (HM1 IMS strain) crude extract Antigen in Complete Freund's Adjuvant Induced Rheumatoid Arthritis Female Wistar Rats. Antiinflamm Antiallergy Agents Med Chem. 2015;14:113-27 pubmed
    ..This study was to evaluate immunomodulatory effects of crude Entamoeba histolytica (HM1 IMS strain) antigen in complete freund's adjuvant female wistar rats by studying the alterations in humoral and ..
  49. Toledano Magaña Y, García Ramos J, Navarro Olivarria M, Flores Alamo M, Manzanera Estrada M, Ortiz Frade L, et al. Potential amoebicidal activity of hydrazone derivatives: synthesis, characterization, electrochemical behavior, theoretical study and evaluation of the biological activity. Molecules. 2015;20:9929-48 pubmed publisher
    ..and electrochemical analysis of each compound, amoebicidal activity was tested in vitro against the HM1:IMSS strain of Entamoeba histolytica...
  50. Tavano B, Galao R, Graham D, Neil S, Aquino V, Fuchs D, et al. Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes. J Immunol. 2013;190:2622-30 pubmed publisher
    ..The bone marrow stromal cell Ag 2 (BST2, aka HM1.24, tetherin, or CD317) is expressed by different cell types upon exposure to IFN-I and is a natural ligand for ..
  51. Aceves Cano A, Gaytán Ochoa R, Ramos Martínez E, Erosa de la Vega G, González Horta C, Talamás Rohana P, et al. Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALB/c Mice. Biomed Res Int. 2015;2015:898467 pubmed publisher
    ..5 × 10(5) trophozoites of E. histolytica strain HM1:IMSS and treated with 10(-4) M of MPL daily until sacrifice at 2, 4, and 7 days postinfection (p.i.)...
  52. Zuchner T, Schliebe N, Schliebs R. Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells. Int J Dev Neurosci. 2006;24:23-7 pubmed
  53. Katsube T, Murayama M, Yamaguchi K, Usuda A, Shimazaki A, Asaka S, et al. Additional Surgery After Non-curative Resection of ESD for Early Gastric Cancer. Anticancer Res. 2015;35:2969-74 pubmed
    ..7% in group A and 14.3% in group B. Risk factors were piecemeal resection, involvement of the horizontal margin (HM1) or unclear involvement of the horizontal margin (HMX) and with ulceration...
  54. Mohd Shah N, Wan Abdul Wahab W, Mohd Nawi S, Mohd Zain Z, Latif B, Suhaimi R. Comparison of the Anaerocult A and the oil blocking methods for the in vitro cultivation of Entamoeba histolytica. Malays J Pathol. 2015;37:271-4 pubmed
    ..histolytica. The trophozoites of E. histolytica HM1: IMSS strains were axenically cultivated in TYI-S-33 medium in culture incubated anaerobically by using Anaerocult ..
  55. Lin A, Zhu B, Zhang W, Dang H, Zhang B, Katz M, et al. Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line. Am J Physiol Cell Physiol. 2008;294:C1454-64 pubmed publisher
  56. Solismaa A, Kampman O, Seppälä N, Viikki M, Mäkelä K, Mononen N, et al. Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment. Hum Psychopharmacol. 2014;29:336-41 pubmed publisher
    ..The aim of this study was to find out if polymorphisms in muscarinic M1 and M3 receptor genes (CHRM1 and CHRM3), adrenoceptor alpha 2A gene (ADRA2A) or clock circadian regulator gene (CLOCK) are associated with CIS...
  57. Tangsucharit P, Takatori S, Zamami Y, Goda M, Pakdeechote P, Kawasaki H, et al. Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries. J Pharmacol Sci. 2016;130:24-32 pubmed publisher
  58. Sánchez García J, Toledano Magaña Y, Flores Alamo M, Martínez Klimova E, Galindo Murillo R, Hernández Ayala L, et al. Polycyclic ferrocenyl(dihydro)thiazepine derivatives: Diastereo-selective synthesis, characterization, electrochemical behavior, theoretical and biological investigation. J Inorg Biochem. 2017;166:141-149 pubmed publisher
    ..Compounds 4a and 4c showed similar capacity to inhibit the proliferation of HM1: IMSS trophozoite cultures than the first choice drug for human amoebiasis treatment, metronidazole...
  59. Weiss S, Keren Raifman T, Oz S, Ben Mocha A, Haase H, Dascal N. Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of G?? and protein kinase C. Channels (Austin). 2012;6:426-37 pubmed publisher
    ..Our results suggest a complex antagonistic interplay between G(q)-activated PKC and G?? in regulation of L-VDCC, in which multiple cytosolic segments of ?(1C) are involved. ..
  60. Brann M, Ellis J, Jørgensen H, Hill Eubanks D, Jones S. Muscarinic acetylcholine receptor subtypes: localization and structure/function. Prog Brain Res. 1993;98:121-7 pubmed
    ..The residues that contribute to ligand binding and G-protein coupling are described, as well as the implied structures of these functional domains. ..
  61. Tanaka S, Kuratsune H, Hidaka Y, Hakariya Y, Tatsumi K, Takano T, et al. Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome. Int J Mol Med. 2003;12:225-30 pubmed
    ..radioligand assay, we examined serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1), mu-opioid receptor (OPRM1), 5-hydroxytryptamine receptor 1A (HTR1A), and dopamine receptor D2 (DRD2) in patients ..
  62. Falsafi S, Roßner S, Ghafari M, Groessl M, Morawski M, Gerner C, et al. Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets. Amino Acids. 2014;46:223-33 pubmed publisher
    ..Thus, the receptor deficits identified may be relevant for the design of experimental therapies. Therefore, specific pharmacological modulation of these receptors is within the pharmaceutical repertoire. ..
  63. Nitsch R, Slack B, Wurtman R, Growdon J. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science. 1992;258:304-7 pubmed
    ..Receptor-activated APP release was blocked by staurosporine, suggesting that protein kinases mediate neurotransmitter receptor-controlled APP processing. ..
  64. Cheng K, Xie G, Khurana S, Heath J, Drachenberg C, Timmons J, et al. Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Mol Cancer. 2014;13:77 pubmed publisher
    ..Here we investigated the effects of Chrm1 gene ablation, alone and in combination with Chrm3 ablation...
  65. Russell M, Winitz S, Johnson G. Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity. Mol Cell Biol. 1994;14:2343-51 pubmed
    ..In contrast to the m2R, stimulation of the acetylcholine muscarinic m1 receptor (m1R) does not activate the Ras/Raf/mitogen-activated protein kinase regulatory pathway in Rat 1a cells but rather ..
  66. Abdul Ridha A, Lane J, Mistry S, López L, Sexton P, Scammells P, et al. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. J Biol Chem. 2014;289:33701-11 pubmed publisher
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    ..We show that DNA binding proteins interact in vitro with single-stranded DNA derived from these regions and suggest that topology of the DNA is important for regulation of M1 expression. ..
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    ..Therefore blocking M1 and for M3 receptors, by using specific receptor antagonists, can prevent that tau toxic effect that could take place in tauopathies. ..
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    Tetherin (BST2, CD317, or HM1.24) is a host cellular restriction factor that prevents the release of enveloped viruses by mechanically linking virions to the plasma membrane...
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    ..We find that Asn 382(6) forms hydrogen bonds with selected antagonists. Tyr381(6) and Ser 109(3) form hydrogen bonds with the ester moiety of acetylcholine, which binds in the gauche conformation. ..
  82. Ilien B, Glasser N, Clamme J, Didier P, Piemont E, Chinnappan R, et al. Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem. 2009;284:19533-43 pubmed publisher
    ..Fast ligand binding to a peripheral receptor site initiates a sequence of conformational changes that allows the ligand to access to inner regions of the protein and drives ligand-receptor complexes toward a high affinity dimeric state. ..
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    ..Heart rate variability (HRV) was measured as an index of ANS activity. SNPs in CHRM1 (rs542269 and rs2075748), CHRM2 (rs324640, rs8191992, rs1824024, and rs7810473), and CHRM3 (rs3738435, rs4620530, ..
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    ..Two critical recombinants identified in two affected cases placed the MEN1 gene in an approximately 2-Mb region around PYGM, flanked by D11S1883 and D11S449. ..
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    ..3, implicating a role for calcium in these responses. These results indicate that all three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho. ..