CHRM1

Summary

Gene Symbol: CHRM1
Description: cholinergic receptor muscarinic 1
Alias: HM1, M1R, muscarinic acetylcholine receptor M1, acetylcholine receptor, muscarinic 1
Species: human

Top Publications

  1. ncbi On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor
    A Christopoulos
    Division of Neuroscience Research in Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 53:1120-30. 1998
  2. ncbi Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    B Dean
    The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Mol Psychiatry 7:1083-91. 2002
  3. ncbi Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia
    D Mancama
    Section of Clinical Neuropharmacology, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, England, UK
    Am J Med Genet B Neuropsychiatr Genet 119:2-6. 2003
  4. doi Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    E Scarr
    Centre for Neuroscience, The University of Melbourne, Parkville, Vic, Australia
    Mol Psychiatry 14:1017-23. 2009
  5. pmc Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors
    E G Peralta
    Department of Molecular Biology Genentech, Inc South San Francisco, CA 94080
    EMBO J 6:3923-9. 1987
  6. pmc Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene
    J L Lucas
    Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, CA 94143 0446, USA
    AAPS PharmSci 3:E31. 2001
  7. ncbi Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system
    Gregory W Sawyer
    Department of Biochemistry and Microbiology, Center for Health Sciences, Oklahoma State University, 1111 W 17th Street, Tulsa, OK 74107 1898, USA
    J Pharmacol Toxicol Methods 53:219-33. 2006
  8. doi Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor
    Catherine Marquer
    CEA, iBiTec S, Service d Ingenierie Moleculaire des Proteines SIMOPRO, Gif sur Yvette, F 91191, France
    Biol Cell 102:409-20. 2010
  9. ncbi Inhibitory and lytic effects of phenothiazine derivatives and related tricyclic neuroleptic compounds, on Entamoeba histolytica HK9 and HM1 trophozoites
    R N Ondarza
    Center of Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Mor, Mexico, 62508
    Biotechnol Appl Biochem 32:61-7. 2000
  10. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008

Research Grants

  1. Paul S Frenette; Fiscal Year: 2016
  2. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
  3. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
  4. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
  5. The Role of Lipid Rafts in Vpu Function
    EDWARD BRICE STEPHENS; Fiscal Year: 2011
  6. Development of M5 Selective Muscarinic Antagonists
    Guangrong Zheng; Fiscal Year: 2012
  7. Recruitment of BST-2/tetherin to HIV-1 assembly sites
    Akira Ono; Fiscal Year: 2012
  8. HIV-1 Vpu and BST-2/CD317
    John C Guatelli; Fiscal Year: 2013
  9. Functional importance of RGS2/M1 AChR interactions
    KAREN NEITZEL; Fiscal Year: 2006
  10. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009

Detail Information

Publications217 found, 100 shown here

  1. ncbi On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor
    A Christopoulos
    Division of Neuroscience Research in Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Pharmacol 53:1120-30. 1998
    ....
  2. ncbi Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    B Dean
    The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Mol Psychiatry 7:1083-91. 2002
    ..the hypothesis that muscarinic receptors are involved in the pathology of schizophrenia, we measured muscarinic(1) (M1R) and muscarinic(4)(M4R) protein and mRNA as well as [(3)H]pirenzepine binding in Brodmann's areas (BA) 9 and 40 ..
  3. ncbi Reduced expression of the muscarinic 1 receptor cortical subtype in schizophrenia
    D Mancama
    Section of Clinical Neuropharmacology, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, England, UK
    Am J Med Genet B Neuropsychiatr Genet 119:2-6. 2003
    ..These results provide evidence in support of altered muscarinic 1 receptor expression in schizophrenia, though further work is needed to corroborate these findings...
  4. doi Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    E Scarr
    Centre for Neuroscience, The University of Melbourne, Parkville, Vic, Australia
    Mol Psychiatry 14:1017-23. 2009
    ..We have established that the CHRM1 is selectively decreased in the dorsolateral prefrontal cortex of subjects with schizophrenia...
  5. pmc Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors
    E G Peralta
    Department of Molecular Biology Genentech, Inc South San Francisco, CA 94080
    EMBO J 6:3923-9. 1987
    ..Subtype-specific mRNA expression was observed in the heart, pancreas and a neuronal cell line, indicating that the regulation of mAChR gene expression contributes to the differentiation of cholinergic activity...
  6. pmc Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene
    J L Lucas
    Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, CA 94143 0446, USA
    AAPS PharmSci 3:E31. 2001
    The gene encoding the human muscarinic receptor, type 1 (CHRM1), was genotyped from 245 samples of the Coriell Collection (Coriell Institute for Medical Research, Camden, NJ)...
  7. ncbi Determination of the rate of muscarinic M1 receptor plasma membrane delivery using a regulated secretion/aggregation system
    Gregory W Sawyer
    Department of Biochemistry and Microbiology, Center for Health Sciences, Oklahoma State University, 1111 W 17th Street, Tulsa, OK 74107 1898, USA
    J Pharmacol Toxicol Methods 53:219-33. 2006
    In this study, we used the regulated secretion/aggregation technology (RPD) to determine the rate of human muscarinic M1 (hM1) receptor plasma membrane delivery.
  8. doi Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor
    Catherine Marquer
    CEA, iBiTec S, Service d Ingenierie Moleculaire des Proteines SIMOPRO, Gif sur Yvette, F 91191, France
    Biol Cell 102:409-20. 2010
    ..We chose to focus our present study on the effect of MT7 (muscarinic toxin 7), a highly selective allosteric peptide ligand, on the oligomerization state of the hM1 (human M1 muscarinic acetylcholine receptor subtype).
  9. ncbi Inhibitory and lytic effects of phenothiazine derivatives and related tricyclic neuroleptic compounds, on Entamoeba histolytica HK9 and HM1 trophozoites
    R N Ondarza
    Center of Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Mor, Mexico, 62508
    Biotechnol Appl Biochem 32:61-7. 2000
    ..histolytica strains showed that normal cell proliferation under anaerobiosis was higher in strain HK9 than in HM1, which is highly virulent, but that metronidazol and clomipramine were less effective against HM1...
  10. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
    ..Overexpression of EhHMGB1 in HM1:IMSS trophozoites led to modulation of 33 transcripts involved in a variety of cellular functions...
  11. ncbi Development of a pharmacodynamic screening model with Entamoeba histolytica
    Oumaporn Tasanor
    Institute for Specific Prophylaxis und Tropical Medicine, Center for Physiology und Pathophysiology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:88-95. 2007
    ..with bovine serum, proved to be suitable for the maintenance of the stock cultures of Entamoeba histolytica strain HM1:1MSS. For sensitivity testing, Waymouth medium and cultivation under aerobic conditions were most reliable...
  12. doi Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist
    G Villetti
    Department of Preclinical Research and Development, Chiesi Farmaceutici SpA, Parma, Italy
    J Pharmacol Exp Ther 335:622-35. 2010
    ..2.2]octane bromide (CHF5407) showed subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2), and M3 (hM3) receptors and dissociated very slowly from hM3 receptors (t(½) = 166 min) with ..
  13. ncbi Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells
    T Ohtomo
    Chugai Pharmaceutical Co, Ltd, Fuji Gotemba Research Labs, 1 135 Komakado, Gotemba shi, Shizuoka, 412 8513, Japan
    Biochem Biophys Res Commun 258:583-91. 1999
    b>HM1.24 antigen has been identified as a surface molecule preferentially expressed on terminally differentiated B cells, and its overexpression is observed in multiple myeloma cells. The HM1...
  14. pmc Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen
    Francisco Silva
    Thoracic Diseases Research Unit, Stabile Bldg 8 56, Division of Pulmonary and Critical Care Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Autoimmun 35:299-308. 2010
    ..coated with recombinant human (H) and murine (M) PR3 and 10 custom-designed chimeric human/mouse rPR3-variants (Hm1-5/Mh1-5) identifying 5 separate non-conserved PR3 surface epitopes...
  15. ncbi Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6
    H Tsuga
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Pharmacol Exp Ther 284:1218-26. 1998
    ....
  16. doi Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia
    Adel Barakat
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Schizophr Res 124:200-7. 2010
    ..Having recently shown that CHRM1 levels are decreased selectively in frontal cortex regions of a subpopulation of schizophrenic patients (..
  17. ncbi Autoantibodies against four kinds of neurotransmitter receptors in psychiatric disorders
    Susumu Tanaka
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine D2, Yamada oka 2 2, Osaka 565 0871, Suita, Japan
    J Neuroimmunol 141:155-64. 2003
    ..radioligand assay, we detected serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1, 34.4%), mu-opioid receptor (OPRM1, 13.1%), 5-hydroxytryptamine receptor 1A (HTR1A, 7...
  18. doi New derivatives of 3,5-substituted-1,4,2-dioxazoles: synthesis and activity against Entamoeba histolytica
    Abdul R Bhat
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Eur J Med Chem 44:926-36. 2009
    ..and 3-p-chloro (23-33) dioxazoles having same substituents at 5-position of dioxazole ring, was performed against HM1:IMSS strain of Entamoeba histolytica...
  19. doi Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity
    Asha Budakoti
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Eur J Med Chem 44:1317-25. 2009
    ..derivatives (1b-8b) and evaluated for their in vitro antiamoebic activity against HM1:IMSS strain of E. histolytica...
  20. ncbi Induction of a proliferative response of T cells by a high-molecular antigen in Dermatophagoides farinae feces
    Airo Tategaki
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Kagamiyama 1 4 1, Higashi Hiroshima 739 8527, Japan
    Int Arch Allergy Immunol 127:276-84. 2002
    We have previously demonstrated that high-molecular mite antigen (HM1) from Dermatophagoides farinae feces is an allergen which binds to mite-allergic patients IgE...
  21. ncbi Cloning and mapping of a putative barley NADPH-dependent HC-toxin reductase
    F Han
    Department of Crop and Soil Sciences, Washington State University, Pullman 99164 6420, USA
    Mol Plant Microbe Interact 10:234-9. 1997
    The NADPH-dependent HC-toxin reductase (HCTR), encoded by Hm1 in maize, inactivates HC-toxin produced by the fungus Cochliobolus carbonum, and thus confers resistance to the pathogen. The fact that C...
  22. pmc Population genetics of duplicated disease-defense genes, hm1 and hm2, in maize (Zea mays ssp. mays L.) and its wild ancestor (Zea mays ssp. parviglumis)
    Liqing Zhang
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    Genetics 162:851-60. 2002
    ..Here we investigate the evolutionary dynamics of the duplicated defense genes hm1 and hm2 in maize and its wild ancestor Zea mays ssp. parviglumis...
  23. ncbi Anti-inflammatory, analgesic and antiamoebic activity evaluation of pyrimido[1,6-a]benzimidazole derivatives synthesized by the reaction of ketoisothiocyanates with mono and diamines
    Sham M Sondhi
    Department of Chemistry, I I T Roorkee, Roorkee 247667 UA, India
    Eur J Med Chem 37:835-43. 2002
    ..Antiamoebic activity evaluations (using microdilution method) of 2a-g against Entamoeba-histolytica (strain HM1: IMSS) were carried out and compounds 2a, 2b, 2d and 2g exhibited good antiamoebic activity in vitro.
  24. ncbi Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice
    Masaaki Takemura
    Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako 351 0198, Japan
    J Neurosci 22:6972-9. 2002
    ..Gfap(hm1/hm1) and Gfap(hm2/hm2) mice, which carry substitutions at three of five sites and in different combinations, showed ..
  25. pmc HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin
    Naoko Masuyama
    Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Biol Chem 284:15927-41. 2009
    b>HM1.24/Bst2/CD317 is a protein highly expressed in multiple myeloma cells and has unique topology with two membrane anchor domains, an NH2-terminal transmembrane domain and a glycosylphosphatidylinositol attached to the COOH terminus...
  26. ncbi Expression of the mouse gap junction gene Gjb3 is regulated by distinct mechanisms in embryonic stem cells and keratinocytes
    Achim Plum
    Institut fur Genetik, Romerstrasse 164, D 53117 Bonn, Germany
    Genomics 79:24-30. 2002
    ..of mouse Gjb3 as well as its transcriptional regulation by transient transfection of reporter gene constructs in HM1 mouse embryonic stem cells and a mouse keratinocytederived cell line, Hel37, as model systems for early development ..
  27. pmc HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation
    Bastien Mangeat
    Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland
    PLoS Pathog 5:e1000574. 2009
    ..Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells...
  28. doi Entamoeba histolytica: expression and localization of Gal/GalNAc lectin in virulent and non-virulent variants from HM1:IMSS strain
    R Lopez-Vancell
    Medicine Faculty, National Autonomus University of Mexico, General Hospital of Mexico, Mexico City, Mexico
    Exp Parasitol 125:244-50. 2010
    ..localization of the amoebic lectin in both virulent (vEh) and non-virulent (nvEh) variants of axenically cultured HM1:IMSS strain. vEh is able to induce liver abscesses in hamsters, whereas nvEh has lost this ability...
  29. pmc Plant-pathogen microevolution: molecular basis for the origin of a fungal disease in maize
    D S Multani
    Department of Agronomy, 205 Curtis Hall, University of Missouri, Columbia, MO 65211 7020, USA
    Proc Natl Acad Sci U S A 95:1686-91. 1998
    ..carbonum race 1 was found to be widespread in maize and is conferred by a pair of unlinked duplicate genes, Hm1 and Hm2. Here, we demonstrate that resistance is the wild-type condition in maize...
  30. ncbi Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry
    Miriam Vidal-Laliena
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Casanova 143, Barcelona E 08036, Spain
    Cell Immunol 236:6-16. 2005
    ..Our results have permitted us to characterize the expression of 10 new CD molecules: CD316 (HM1.24, BST2), CD268 (BAFF-R, TNFRSF13C), CD269 (BCMA, TNFRF17), CD267 (TACI, TNFRSF13B), CD275 (ICOSL, B7H2), CD254 (..
  31. ncbi Recognition of carbohydrate epitopes specific for electron-dense granule antigens from Entamoeba histolytica by monoclonal antibodies in the cecal content of infected hamsters
    S Arias-Negrete
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Universidad de Guanajuato, 36050 Guanajuato, Gto, Mexico
    Curr Microbiol 43:403-7. 2001
    ..E. histolytica HM1 axenic and monoxenic trophozoites were inoculated into the cecum according to the washed-closed cecal loop ..
  32. ncbi Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure
    Silvia Dei
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, via U Schiff 6, 50019 Sesto Fiorentino FI, Italy
    J Med Chem 50:1409-13. 2007
    ..All the tested compounds show a high affinity toward cloned human muscarinic hm1-hm5 receptors expressed in CHO cells and a good antagonistic activity on functional assays, with a modest ..
  33. doi Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus
    Michael S Samuel
    The Beatson Institute for Cancer Research, Glasgow, United Kingdom
    Genesis 47:440-6. 2009
    ..Homologous recombination into the Hprt locus, which is deleted for the promoter and first two exons in HM1 embryonic stem cells, reconstitutes a functional Hprt gene, allowing for growth in HAT (hypoxanthine-aminopterin-..
  34. doi Ultrastructural changes on Entamoeba histolytica HM1-IMSS caused by the flavan-3-ol, (-)-epicatechin
    Jacqueline Soto
    Laboratorio de Biomedicina Molecular 1, Escuela Nacional de Medicina y Homeopatía IPN, Mexico City, Mexico
    Planta Med 76:611-2. 2010
    ..These morphological alterations are identical to the cellular changes experienced by E. histolytica trophozoites undergoing programmed cell death (PCD), suggesting that epicatechin could be an alternative compound to treat amoebiasis...
  35. ncbi Molecular analysis of repetitive DNA elements from Entamoeba histolytica, which encode small RNAs and contain matrix/scaffold attachment recognition sequences
    Sulagna Banerjee
    Department of Biochemistry, Bose Institute, P1 12 CIT Scheme VIIM, Calcutta 700054, India
    Mol Biochem Parasitol 126:35-42. 2003
    ..histolytica HM1:IMSS, suggesting that the predicted S/MAR recognition sequences may indeed function as scaffold attachment regions ..
  36. ncbi [Analysis and mapping of homologous sequences of barley disease resistance gene Mlo and maize disease resistance gene Hm1 in rice]
    Wei Dong Liu
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Yi Chuan Xue Bao 29:875-9. 2002
    The encoding products of the disease resistance (R) gene of barley, Mlo, and the maize R gene, Hm1, do not contain the recognizable structural domains of most of the known plant R gene products...
  37. ncbi Homo- or hetero-dimerization of muscarinic receptor subtypes is not mediated by direct protein-protein interaction through intracellular and extracellular regions
    Yun Kyung Kang
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Arch Pharm Res 26:846-54. 2003
    ..loops (i1, i2 and i3) and the C-terminal cytoplasmic tails (C) of human muscarinic (Hm) receptor subtypes, Hm1, Hm2 and Hm3, were cloned into the vectors (pB42AD and pLexA) of a two-hybrid system and examined for heteromeric ..
  38. ncbi Inhibition of gene expression with double strand RNA interference in Entamoeba histolytica
    Gursharan Kaur
    Department of Biochemistry, Bose Institute, Kolkata, India
    Biochem Biophys Res Commun 320:1118-22. 2004
    ..histolytica expression vector pJST4. This construct was transformed in E. histolytica HM1:IMSS trophozoites and stable transformants were selected with 20microg/ml G418...
  39. ncbi [Expression of muscarinic acetylcholine receptor-1 in human scleral fibroblasts]
    Xiang Tian Zhou
    School of Optometry and Ophthalmology, Wenzhou Medical College, Wenzhou 325003, China
    Zhonghua Yan Ke Za Zhi 41:995-9. 2005
    ..The aim of this study was to identify the presence of muscarinic acetylcholine receptors-1 (mAChRs-1) in human sclera in order to determine whether the sclera is a potential site of action for mAChR antagonists...
  40. ncbi Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives
    Mohammad Abid
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Bioorg Med Chem Lett 16:2812-6. 2006
    ..The HM1:IMSS strain of Entamoeba histolytica parasite was cultured in vitro and the sensitivity of the parasite to the ..
  41. ncbi Synthesis, characterization and antiamoebic activity of new indole-3-carboxaldehyde thiosemicarbazones and their Pd(II) complexes
    Kakul Husain
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Eur J Med Chem 42:1300-8. 2007
    ..Among all the compounds evaluated for antiamoebic activity using HM1:IMSS strain of Entamoeba histolytica, all palladium complexes were found to be more active than their respective ..
  42. doi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..Using deductive constraints and gene expression analyses, we identify CD317 (also called BST2 or HM1.24), a membrane protein of previously unknown function, as a tetherin...
  43. pmc A guardian of grasses: specific origin and conservation of a unique disease-resistance gene in the grass lineage
    Anoop Sindhu
    Department of Botany and Plant Pathology, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 105:1762-7. 2008
    The maize Hm1 gene provides protection against a lethal leaf blight and ear mold disease caused by Cochliobolus carbonum race 1 (CCR1)...
  44. ncbi Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth
    Estelle Merck
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Immunol 182:183-92. 2009
    ..that Ly49D-transgenic CD8 T cells are able to control growth of CHO tumor cells or RMA cells transfected with Hm1-C4, the Ly49D ligand normally expressed by CHO...
  45. pmc Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia
    Hui Ju Lin
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Mol Vis 15:1774-80. 2009
    ..Our specific aim in this study was to examine the association between high myopia and polymorphisms within the muscarinic acetylcholine receptors 1 gene (CHRM1).
  46. pmc BST-2 diminishes HIV-1 infectivity
    Jianyong Zhang
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    J Virol 84:12336-43. 2010
    Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin/CD317/HM1.24) inhibits the release of human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses by tethering virus particles to the cell surface...
  47. doi Synthesis, characterization, antiamoebic activity and cytotoxicity of new pyrazolo[3, 4-d]pyrimidine-6-one derivatives
    Faisal Hayat
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    J Enzyme Inhib Med Chem 26:472-9. 2011
    ..In vitro antiamoebic activity was performed against HM1:IMSS strain of Entamoeba histolytica. The results showed that the compounds 2b, 2i, and 2j with IC(50) values of 0...
  48. pmc Tetherin restricts direct cell-to-cell infection of HIV-1
    Björn D Kuhl
    McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
    Retrovirology 7:115. 2010
    Tetherin (BST-2/CD317/HM1.24) is an interferon (IFN)-inducible factor of the innate immune system, recently shown to exert antiviral activity against HIV-1 and other enveloped viruses by tethering nascent viral particles to the cell ..
  49. pmc Tetherin and its viral antagonists
    Björn D Kuhl
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Neuroimmune Pharmacol 6:188-201. 2011
    ..interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1.24) was recently discovered to block the release of enveloped viruses from the cell surface, which is regarded as a ..
  50. ncbi 293 MASS PRODUCTION OF Nkx2.5-POSITIVE CARDIAC PROGENITOR CELLS DERIVED FROM MOUSE EMBRYONIC STEM CELLS IN SLOW-TURNING LATERAL VESSEL FOR CELL TRANSPLANTATION AND DRUG TESTING
    S Rungarunlert
    Applied Animal Biotechnology Group, Agricultural Biotechnology Center, Godollo, Hungary
    Reprod Fertil Dev 23:244. 2011
    ..To enhance the yield of cardiac progenitor cells, mouse ES cells (HM1; 129Sv/Ola, Magin et al. 1992 Nucl. Acids Res. 20, 3795-3796) were targeted with the cardiac-specific mouse Nkx2...
  51. pmc Tetherin inhibits prototypic foamy virus release
    Fengwen Xu
    Key Laboratory of Molecular Microbiology and Biotechnology Ministry of Education and Key Laboratory of Microbial Functional Genomics Tianjin, College of Life Sciences, Nankai University, Tianjin 300071, China
    Virol J 8:198. 2011
    Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses...
  52. pmc Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba
    Gareth D Weedall
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 5:e1209. 2011
    ..We present evidence that gene conversion has occurred in lineages leading to E. histolytica strain HM1:IMSS and E. dispar strain SAW760...
  53. doi Isolation of a new strain of Picochlorum sp and characterization of its potential biotechnological applications
    M de la Vega
    Lab Bioquímica, Departamento de Química y Ciencia de Materiales, Facultad de Ciencias Experimentales, University of Huelva, Avda Fuerzas Armadas s n, Huelva, Spain
    Biotechnol Prog 27:1535-43. 2011
    ..total lipid content is not particularly high, 23% of the dry weight, its fatty acid profile makes of Picochlorum sp HM1 a promising candidate for biodiesel production, and the high content in the carotenoids lutein and zeaxanthin ..
  54. pmc The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin
    Annika Kühl
    Institute of Virology, Hannover Medical School, Germany
    J Infect Dis 204:S850-60. 2011
    The antiviral protein tetherin/BST2/CD317/HM1.24 restricts cellular egress of human immunodeficiency virus (HIV) and of particles mimicking the Ebola virus (EBOV), a hemorrhagic fever virus...
  55. doi Porcine colon explants in the study of innate immune response to Entamoeba histolytica
    Fabienne Girard-Misguich
    Institut Pasteur, Unité Biologie Cellulaire du Parasitisme, Paris, France
    Vet Immunol Immunopathol 145:611-7. 2012
    ..Porcine colonic explants were cultured with two strains of E. histolytica, one virulent (HM1:IMSS) and one avirulent (Rahman)...
  56. pmc Influenza virus partially counteracts restriction imposed by tetherin/BST-2
    Bastien Mangeat
    Department of Dermatology and Wound Healing, Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:22015-29. 2012
    ..Interestingly, a recently identified IFN-induced cellular protein, tetherin (also known as CD317, BST-2, or HM1.24), exerts potent antiviral activity against a broad range of retroviruses, as well as several other enveloped ..
  57. doi Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors
    Md Mushtaque
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Eur J Med Chem 55:439-48. 2012
    ..The in vitro antiamoebic activity of these compounds was evaluated against HM1:IMSS strain of Entamoeba histolytica. Eight compounds exhibited promising activity with IC(50) values (0.11-0...
  58. pmc Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities
    Luis J Cocka
    Department of Microbiology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Pathog 8:e1002931. 2012
    Tetherin (BST-2/CD317/HM1.24) is an IFN induced transmembrane protein that restricts release of a broad range of enveloped viruses. Important features required for Tetherin activity and regulation reside within the cytoplasmic domain...
  59. pmc Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor
    Alaa Abdul-Ridha
    From Drug Discovery Biology and
    J Biol Chem 289:6067-79. 2014
    ..This new insight into the structural basis of binding and function of BQCA can guide the design of new allosteric ligands with tailored pharmacological properties. ..
  60. pmc Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking
    Holly R Yeatman
    From the Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia and
    J Biol Chem 289:15856-66. 2014
    ....
  61. pmc Counteraction of the multifunctional restriction factor tetherin
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center Ulm, Germany
    Front Microbiol 5:163. 2014
    The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1.24) has emerged as a key component of the antiviral immune response...
  62. pmc Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors
    Pavel Michal
    Institute of Physiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, 14220, Prague, Czech Republic
    Neurochem Res 40:2068-77. 2015
    ..On the other hand, modifications in agonist-stimulated GTP-γ(35)S binding in CHO-M3 membranes indicate that in this case changes in ligand-activated receptor/G-protein interaction may also play a role...
  63. pmc Structure-based computational study of two disease resistance gene homologues (Hm1 and Hm2) in maize (Zea mays L.) with implications in plant-pathogen interactions
    Budheswar Dehury
    Department of Agricultural Biotechnology, Assam Agricultural University, Jorhat, Assam, India Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India
    PLoS ONE 9:e97852. 2014
    ..HC-toxin reductases (HCTR1 and 2) encoded by enzymatic class of disease resistance homologous genes (Hm1 and Hm2) protect maize by detoxifying a cyclic tetrapeptide, HC-toxin, secreted by the fungus Cochliobolus carbonum ..
  64. pmc Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor
    Alaa Abdul-Ridha
    From the Departments of Drug Discovery Biology and
    J Biol Chem 289:33701-11. 2014
    ....
  65. doi Novel aryl carbamate derivatives of metronidazole as potential antiamoebic agents
    Faisal Hayat
    College of Pharmacy, Gachon University, 191 Hambakmoe ro, Yeonsu gu, Incheon, 406 799, South Korea
    Arch Pharm Res 39:33-42. 2016
    ..As compared to MNZ, most of the derivatives exhibited moderate to excellent activity against the HM1:IMSS strain of Entamoeba histolytica...
  66. doi 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor
    Shailesh N Mistry
    Medicinal Chemistry and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria Australia
    J Med Chem 59:388-409. 2016
    ..Thus, the 4-phenylpyridin-2-one scaffold offers an attractive starting point for further lead optimization. ..
  67. ncbi Comparison of the Anaerocult A and the oil blocking methods for the in vitro cultivation of Entamoeba histolytica
    Nurul Azira Mohd Shah
    Universiti Teknologi MARA, Faculty of Medicine, Sungai Buloh Campus, 47000 Sungai Buloh, Selangor, Malaysia
    Malays J Pathol 37:271-4. 2015
    ..histolytica. The trophozoites of E. histolytica HM1: IMSS strains were axenically cultivated in TYI-S-33 medium in culture incubated anaerobically by using Anaerocult ..
  68. doi Frequency of expression and generation of T-cell responses against antigens on multiple myeloma cells in patients included in the GMMG-MM5 trial
    Michael Schmitt
    Universitatsklinikum Heidelberg, Medizinische Klinik V, Heidelberg, Germany
    Oncotarget . 2016
    Raising T-cell response against antigens either expressed on normal and malignant plasma cells (e.g. HM1.24) or aberrantly on myeloma cells only (e.g...
  69. pmc DNA methylation profiling in human lung tissue identifies genes associated with COPD
    Jarrett D Morrow
    a Channing Division of Network Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Epigenetics . 2016
    ..The top differentially methylated sites from the intersection with previous GWAS were in CHRM1, GLT1D1, and C10orf11; sorted by GWAS P-value, the top sites included FRMD4A, THSD4, and C10orf11...
  70. ncbi Differential receptor dependencies: expression and significance of muscarinic M1 receptors in the biology of prostate cancer
    Abdul Mannan Baig
    aDepartment of Biological and Biomedical Sciences, Aga Khan University bDepartment of Surgery, Aga Khan University Hospital, Karachi, Pakistan cDepartment of Biological Sciences, Faculty of Science and Technology, Sunway University, Subang Jaya, Malaysia
    Anticancer Drugs 28:75-87. 2017
    ..This study shows that the type 1 acetylcholine muscarinic receptor (CHRM1) contributes toward the proliferation and growth of prostate cancer...
  71. doi Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics
    Masatoshi Miyauchi
    Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
    Neuropsychobiology 74:60-67. 2016
    ..This study sought to determine the effect of SNPs of the cholinergic muscarinic receptor (CHRM) gene on ANS activity in patients with schizophrenia receiving antipsychotic drugs...
  72. pmc A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica
    P R Cieslak
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 176:1605-9. 1992
    ..Seven of seven SCID mice developed liver abscesses when challenged intrahepatically with virulent HM1:IMSS strain E. histolytica trophozoites. Only one of seven similarly challenged immunocompetent congenic C...
  73. ncbi Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450
    K Ohta
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochim Biophys Acta 996:142-5. 1989
    ..P-450-MK2 catalyzed nifedipine and nilvadipine oxidations, at a rate comparable to human P-450-HM1. The N-terminal amino acid sequence of P-450-MK2 was highly homologous to those of P-450-HM1 and NF 25...
  74. ncbi Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C
    K Haga
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 271:2776-82. 1996
    Human muscarinic acetylcholine receptor m1 subtypes (m1 receptors) were expressed in and purified from insect Sf9 cells and then subjected to phosphorylation by G protein-coupled receptor kinase 2 (GRK2) expressed in and purified from Sf9 ..
  75. ncbi Entamoeba dispar: ultrastructure, surface properties and cytopathic effect
    M Espinosa-Cantellano
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico
    J Eukaryot Microbiol 45:265-72. 1998
    ..histolytica strain HM1:IMSS. Under the light microscope the periphery of the nucleus in E...
  76. ncbi Entamoeba histolytica disturbs the tight junction complex in human enteric T84 cell layers
    A Leroy
    Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, B 9000 Gent, Belgium
    FASEB J 14:1139-46. 2000
    ..Trophozoites of E. histolytica strain HM1:IMSS were seeded on the apical side of enteric T84 cell layers, which were established on filters in two-..
  77. ncbi Entamoeba histolytica: sequence conservation of the Gal/GalNAc lectin from clinical isolates
    David L Beck
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Exp Parasitol 101:157-63. 2002
    ..Interestingly, we observed only slight genetic diversity in the lectin gene as compared with the HM1:IMSS laboratory strain, originally a clinical isolate from Mexico...
  78. ncbi New immortalized human stromal cell lines enhancing in vitro expansion of cord blood hematopoietic stem cells
    Sergio De Angeli
    Cell Culture Laboratory, Transfusional Center, Treviso Regional Hospital, I 31100 Treviso, Italy
    Int J Mol Med 13:363-71. 2004
    ..with the temperature-sensitive SV40 large T antigen three new human cell lines, two derived from bone marrow (HM1-SV40 and HM2-SV40) and one from umbilical cord (HCB1-SV40), and investigated the inductive capacity of their ..
  79. ncbi Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters
    A Olivos-Garcia
    Department of Experimental Medicine, National Autonomous University of Mexico Medical School, Mexico City, Mexico
    Parasitology 129:19-25. 2004
    Axenic trophozoites of Entamoeba histolytica strain HM1-IMSS grown in vitro in the presence of E-64, a potent irreversible inhibitor of cysteine proteinases, preserved their viability, their rate of replication, their resistance to ..
  80. pmc Enhanced dihydroflavonol-4-reductase activity and NAD homeostasis leading to cell death tolerance in transgenic rice
    Mitsunori Hayashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 102:7020-5. 2005
    The maize Hm1 gene encoding the NADPH-dependent HC-toxin reductase is capable of detoxifying HC-toxin of fungus Cochliobolus carbonum...
  81. ncbi The anti-amoebic activity of some medicinal plants used by AIDS patients in southern Thailand
    Nongyao Sawangjaroen
    Natural Products Research Unit and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand
    Parasitol Res 98:588-92. 2006
    ..were screened, at a concentration of 1,000 microg/ml, against Entamoeba histolytica strain HTH-56:MUTM and strain HM1:IMSS growing in vitro. The extracts were incubated with 2x10(5) E...
  82. ncbi Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist
    Serena Scapecchi
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy
    J Med Chem 49:1925-31. 2006
    ..expressed in CHO cells show that the introduction of a fourth stereogenic center gives undetectable affinity for hm1, hm3, hm4 and hm5 subtypes while leaving a quite modest affinity only for hm2 subtypes...
  83. ncbi Androgen receptor-mediated repression of novel target genes
    Jennifer Prescott
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 67:1371-83. 2007
    ....
  84. doi Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells
    Silvia Reina
    Argentine National Research Council CONICET, Buenos Aires, Argentina
    J Cell Physiol 222:640-7. 2010
    ..These results may contribute to a better understanding of the modulatory role of the parasympathetic muscarinic system on the apoptotic human skin fibroblast process...
  85. doi The prevalence and the prognostic value of microvolt T-wave alternans in patients with hypertrophic cardiomyopathy
    Ewa Trzos
    Department of Cardiology, Bieganski Hospital, Medical University of Lodz, Lodz, Poland
    Ann Noninvasive Electrocardiol 16:276-86. 2011
    ..The aim of the study was to determine the significance of TWA in predicting nVT episodes and compare how other electrocardiographic parameters can predict the occurrence of nVT...
  86. pmc Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
    Bruce J Melancon
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 22:3467-72. 2012
    ..These results and the implications of a bitopic mode of action are presented...
  87. pmc Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits
    Briana J Davie
    Medicinal Chemistry and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
    ACS Chem Neurosci 4:1026-48. 2013
    ....
  88. doi Activation of intracellular phosphoinositide signaling after a single 600 nanosecond electric pulse
    Gleb P Tolstykh
    National Research Council, Fort Sam Houston, TX, USA
    Bioelectrochemistry 94:23-9. 2013
    ..that the nsPEF-induced activation mirrors the response of M1-acetylcholine Gq/11-coupled metabotropic receptor (hM1)...
  89. doi Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica
    Blanca Estela Duque-Montaño
    Laboratorio de Microbiologia, Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Av Universidad 1001, 62209 Cuernavaca, Mexico
    Bioorg Med Chem 21:4550-8. 2013
    ..Antiamoebic activity was evaluated in vitro against Entamoeba histolytica strain HM1:IMSS by the microdilution method, and the structure-activity relationship was analyzed...
  90. pmc Prostate cancer progression attributed to autonomic nerve development: potential for therapeutic prevention of localized and metastatic disease
    Elena V Fernández
    Molecular Pharmacology Section Medical Oncology Branch National Cancer Institute Bethesda, MD USA
    Cancer Biol Ther 14:1005-6. 2013
    ..Inhibition of the PNS by way of the cholinergic receptor, muscarinic 1 (Chrm1), caused mice to develop less metastases to the pelvic lymph nodes, intestines, and bones...
  91. doi Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets
    Soheil Keihan Falsafi
    Department of Pediatrics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Amino Acids 46:223-33. 2014
    ..Thus, the receptor deficits identified may be relevant for the design of experimental therapies. Therefore, specific pharmacological modulation of these receptors is within the pharmaceutical repertoire...
  92. doi Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms
    Alena Randáková
    Institute of Physiology Czech Academy of Sciences, v v i, 142 20 Prague, Czech Republic
    Pharmacol Res 97:27-39. 2015
    ..Our data show that both classical and atypical agonists activate hM1 receptors by the same molecular switch that involves D71 in the second transmembrane helix...
  93. pmc Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALB/c Mice
    Andrés Aceves-Cano
    Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Circuito No 1, Nuevo Campus Universitario, 31125 Chihuahua, Chih, Mexico
    Biomed Res Int 2015:898467. 2015
    ..5 × 10(5) trophozoites of E. histolytica strain HM1:IMSS and treated with 10(-4) M of MPL daily until sacrifice at 2, 4, and 7 days postinfection (p.i.)...
  94. doi The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia
    Vanessa L Cropley
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia Electronic address
    Psychiatry Res 234:182-7. 2015
    ..267C>A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test (WCST) than those who are heterozygous...
  95. doi Carbachol dimers as homobivalent modulators of muscarinic receptors
    Rosanna Matucci
    Department of Neuroscience, Psychology, Drug Research and Child s Health, Section of Pharmacology and Toxicology, University of Florence, Viale G Pieraccini 6, 50139 Firenze, Italy Electronic address
    Biochem Pharmacol 108:90-101. 2016
    ..The new compounds have been tested on the five cloned muscarinic receptors (hM1-5) expressed in CHO cells by means of equilibrium binding studies, showing an increase in affinity by rising the ..
  96. pmc Identification of wheat chromosomal regions containing expressed resistance genes
    Muharrem Dilbirligi
    Department of Crop and Soil Science, Washington State University, Pullman, Washington 99164, USA
    Genetics 166:461-81. 2004
    ..These include 87 NB/LRR types, 16 receptor-like kinases, and 13 Pto-like kinases. The remaining were seven Hm1 and two Hs1(pro-1) homologs, 17 pathogenicity related, and 42 unique NB/kinases...
  97. ncbi Synthesis and antiamoebic activity of new oxime ether derivatives containing 2-acetylpyridine/2-acetylfuran
    Mohammad Abid
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Bioorg Med Chem Lett 15:4375-9. 2005
    ..All the compounds were screened in vitro against the HM1:IMSS strain of Entamoeba histolytica...
  98. ncbi Dioxo- and oxovanadium(V) complexes of thiohydrazone ONS donor ligands: synthesis, characterization, reactivity, and antiamoebic activity
    Mannar R Maurya
    Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
    Inorg Chem 45:1260-9. 2006
    ..In vitro antiamoebic activities (against HM1:1MSS strain of Entamoeba histolytica) were established for all of the dioxo- and oxovanadium(V) complexes...
  99. doi Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives
    Prince Firdoos Iqbal
    Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    Eur J Med Chem 44:2252-9. 2009
    ..Subsequently, all the compounds were assessed for antiamoebic activity against HM1:IMMS strain of Entamoeba histolytica...
  100. doi HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody
    Wei Wang
    Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho, Tokushima, Japan
    Cancer Immunol Immunother 58:967-76. 2009
    b>HM1.24 antigen (CD317) was originally identified as a cell surface protein that is preferentially overexpressed on multiple myeloma cells. Immunotherapy using anti-HM1...
  101. pmc Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects
    A S Gibbons
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Affect Disord 116:184-91. 2009
    ..However, there is conflicting evidence regarding the association between individual muscarinic receptors and the two disorders...

Research Grants10

  1. Paul S Frenette; Fiscal Year: 2016
    ..We will also evaluate the role of the type 1 muscarinic receptor (Chrm1) using pharmacologic and genetic analyses since our preliminary studies suggest a role for this receptor in ..
  2. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
    ..We will also investigate the inherent virulence repertoire of E. histolytica HM1:IMSS by looking at differences at the transcriptional level between HM1:IMSS and the reduced virulence E...
  3. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..For example, the human leukocyte antigen (HLA)-A2 restricted MM-associated protein HM1.24, which is overexpressed in Multiple myeloma cells, has been shown to stimulate interferon gamma expression by ..
  4. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..histolytica strain HM1:IMSS, analyze and annotate the data and provide ready equal access to the sequence information and analysis through ..
  5. The Role of Lipid Rafts in Vpu Function
    EDWARD BRICE STEPHENS; Fiscal Year: 2011
    ..shown to antagonize the antiviral activities of bone marrow stromal cell antigen 2 (BST-2) also known as CD317, HM1.24, or tetherin...
  6. Development of M5 Selective Muscarinic Antagonists
    Guangrong Zheng; Fiscal Year: 2012
    ..Druggable virtual hits will be evaluated in receptor binding assays using CHO cells expressing hM1-hM5...
  7. Recruitment of BST-2/tetherin to HIV-1 assembly sites
    Akira Ono; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Recent studies showed that a cellular protein known as HM1.24, CD317, BST-2, or tetherin (hereafter referred to as BST-2/tetherin) inhibits HIV-1 particle release by tethering newly assembled virus ..
  8. HIV-1 Vpu and BST-2/CD317
    John C Guatelli; Fiscal Year: 2013
    ..of this inhibitor has recently been revealed: it is the transmembrane, GPI-anchored protein BST-2, also known as HM1.24, CD317, or "tetherin...
  9. Functional importance of RGS2/M1 AChR interactions
    KAREN NEITZEL; Fiscal Year: 2006
    ..Understanding the molecular interactions and functional significance of RGS/GPCR interactions will be critical in advancing our understanding of GPCR signaling and regulation in general. [unreadable] [unreadable]..
  10. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    ..3c) The mechanism whereby bile acids activate metalloproteases will be determined by exploring the roles of PKC, Ca2+, and Src in bile acid-induced HB-EGF release. ..