chondroitin 6 sulfotransferase

Summary

Gene Symbol: chondroitin 6 sulfotransferase
Description: carbohydrate sulfotransferase 3
Alias: C6ST, C6ST1, HSD, carbohydrate sulfotransferase 3, C6ST-1, GST-0, carbohydrate (chondroitin 6) sulfotransferase 3, chondroitin 6 sulfotransferase 1, chondroitin 6-O-sulfotransferase 1, galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Species: human

Top Publications

  1. Antanasova M, Kocjan A, Kovac J, Zuzek B, Jevnikar P. Influence of thermo-mechanical cycling on porcelain bonding to cobalt-chromium and titanium dental alloys fabricated by casting, milling, and selective laser melting. J Prosthodont Res. 2017;: pubmed publisher
    ..Data were analyzed using ANOVA, Tukey's HSD and t-tests (?=0.05). The SBS-means differed according to the metal-ceramic combination (p<0...
  2. Holbein W, Blackburn M, Andrade M, Toney G. Burst Patterning of Hypothalamic Paraventricular Nucleus-Driven Sympathetic Nerve Activity in Angiotensin II-Salt Hypertension. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00560.2017 pubmed publisher
    ..Here, integrated sSNA was elevated in AngII infused rats fed a high salt (2% NaCl) diet (AngII-HSD) compared to vehicle infused rats fed a normal salt (0.4% NaCl) diet (Veh-NSD) (P<0.01)...
  3. Gelberg L, Andersen R, Rico M, Vahidi M, Natera Rey G, Shoptaw S, et al. A pilot replication of QUIT, a randomized controlled trial of a brief intervention for reducing risky drug use, among Latino primary care patients. Drug Alcohol Depend. 2017;179:433-440 pubmed publisher
    ..Primary outcome was reduction in number of days of drug use in past 30days of the highest scoring drug (HSD) on the baseline ASSIST, from baseline to 3-month follow-up...
  4. Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, et al. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. J Biochem. 2000;128:763-70 pubmed
    ..adenocarcinoma and peripheral blood leukocytes, whereas strong expression of human chondroitin 6-sulfotransferase (C6ST) is observed in aorta and testis...
  5. Pavillard L, Cañadas Lozano D, Alcocer Gómez E, Marín Aguilar F, Pereira S, Robertson A, et al. NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget. 2017;8:99740-99756 pubmed publisher
    ..Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks...
  6. Hatfield G, Charlton J, Cochrane C, Hammond C, Napier C, Takacs J, et al. The Biomechanical Demands on the Hip During Progressive Stepping Tasks. J Strength Cond Res. 2017;31:3444-3453 pubmed publisher
    ..and adduction moment impulses, and gluteus medius (GM) and quadriceps activity compared with half step-down (HSD) and SU...
  7. Zang Z, Fang Y, Ji S, Gao Y, Zhu Y, Xia T, et al. Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J Sex Med. 2017;14:1297-1306 pubmed publisher
    ..regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme, and 3?-hydroxysteroid dehydrogenase (3?-HSD), also were decreased in the testes of mice exposed to formaldehyde...
  8. Givehchi S, Hemmativaghef E, Hoveidi H. Association between safety leading indicators and safety climate levels. J Safety Res. 2017;62:23-32 pubmed publisher
    ..38) to 2.98 in workers' safety priority and risk non-acceptance (SD=0.47). Tukey HSD tests indicated a statistically significant difference of mean scores among groups undergoing different number of ..
  9. Searle C, Jewell R, Kraft J, Stoebe P, Chumas P, Titheradge H, et al. Craniosynostosis: a previously unreported association with CHST3-related skeletal dysplasia (autosomal recessive Larsen syndrome). Clin Dysmorphol. 2014;23:12-5 pubmed publisher
  10. Konishi K, Ueda S, Kawano M, Osawa S, Tamura T, Hokazono E, et al. Characterization and application of a novel nicotinamide mononucleotide adenylyltransferase from Thermus thermophilus HB8. J Biosci Bioeng. 2017;: pubmed publisher
    ..3.1.5) and (ii) an NAD cycling reaction using 12?-hydroxysteroid dehydrogenase (12?-HSD, EC 1.1.1.176) and diaphorase (DI, EC 1.6.99.3) to accumulate reduced WST-8...

Detail Information

Publications62

  1. Antanasova M, Kocjan A, Kovac J, Zuzek B, Jevnikar P. Influence of thermo-mechanical cycling on porcelain bonding to cobalt-chromium and titanium dental alloys fabricated by casting, milling, and selective laser melting. J Prosthodont Res. 2017;: pubmed publisher
    ..Data were analyzed using ANOVA, Tukey's HSD and t-tests (?=0.05). The SBS-means differed according to the metal-ceramic combination (p<0...
  2. Holbein W, Blackburn M, Andrade M, Toney G. Burst Patterning of Hypothalamic Paraventricular Nucleus-Driven Sympathetic Nerve Activity in Angiotensin II-Salt Hypertension. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00560.2017 pubmed publisher
    ..Here, integrated sSNA was elevated in AngII infused rats fed a high salt (2% NaCl) diet (AngII-HSD) compared to vehicle infused rats fed a normal salt (0.4% NaCl) diet (Veh-NSD) (P<0.01)...
  3. Gelberg L, Andersen R, Rico M, Vahidi M, Natera Rey G, Shoptaw S, et al. A pilot replication of QUIT, a randomized controlled trial of a brief intervention for reducing risky drug use, among Latino primary care patients. Drug Alcohol Depend. 2017;179:433-440 pubmed publisher
    ..Primary outcome was reduction in number of days of drug use in past 30days of the highest scoring drug (HSD) on the baseline ASSIST, from baseline to 3-month follow-up...
  4. Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, et al. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. J Biochem. 2000;128:763-70 pubmed
    ..adenocarcinoma and peripheral blood leukocytes, whereas strong expression of human chondroitin 6-sulfotransferase (C6ST) is observed in aorta and testis...
  5. Pavillard L, Cañadas Lozano D, Alcocer Gómez E, Marín Aguilar F, Pereira S, Robertson A, et al. NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget. 2017;8:99740-99756 pubmed publisher
    ..Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks...
  6. Hatfield G, Charlton J, Cochrane C, Hammond C, Napier C, Takacs J, et al. The Biomechanical Demands on the Hip During Progressive Stepping Tasks. J Strength Cond Res. 2017;31:3444-3453 pubmed publisher
    ..and adduction moment impulses, and gluteus medius (GM) and quadriceps activity compared with half step-down (HSD) and SU...
  7. Zang Z, Fang Y, Ji S, Gao Y, Zhu Y, Xia T, et al. Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J Sex Med. 2017;14:1297-1306 pubmed publisher
    ..regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme, and 3?-hydroxysteroid dehydrogenase (3?-HSD), also were decreased in the testes of mice exposed to formaldehyde...
  8. Givehchi S, Hemmativaghef E, Hoveidi H. Association between safety leading indicators and safety climate levels. J Safety Res. 2017;62:23-32 pubmed publisher
    ..38) to 2.98 in workers' safety priority and risk non-acceptance (SD=0.47). Tukey HSD tests indicated a statistically significant difference of mean scores among groups undergoing different number of ..
  9. Searle C, Jewell R, Kraft J, Stoebe P, Chumas P, Titheradge H, et al. Craniosynostosis: a previously unreported association with CHST3-related skeletal dysplasia (autosomal recessive Larsen syndrome). Clin Dysmorphol. 2014;23:12-5 pubmed publisher
  10. Konishi K, Ueda S, Kawano M, Osawa S, Tamura T, Hokazono E, et al. Characterization and application of a novel nicotinamide mononucleotide adenylyltransferase from Thermus thermophilus HB8. J Biosci Bioeng. 2017;: pubmed publisher
    ..3.1.5) and (ii) an NAD cycling reaction using 12?-hydroxysteroid dehydrogenase (12?-HSD, EC 1.1.1.176) and diaphorase (DI, EC 1.6.99.3) to accumulate reduced WST-8...
  11. Regnier S, Kirkley A, Ruiz D, Kamau W, Wu Q, Kannan K, et al. Diet-dependence of metabolic perturbations mediated by the endocrine disruptor tolylfluanid. Endocr Connect. 2018;7:159-168 pubmed publisher
    ..Eight-week-old male C57BL/6 mice were fed a high-fat, high-sucrose diet (HFHSD) or a high-sucrose diet (HSD), with or without TF supplementation at 100??g/g, for 12 weeks...
  12. Horton J, Maass D, White J, Sanders B. Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes. Am J Physiol Heart Circ Physiol. 2001;280:H1591-601 pubmed
    Whereas hypertonic saline-dextran (HSD, 7.5% NaCl in 6% D70) improves cardiac contractile function after burn trauma, the mechanisms of HSD-related cardioprotection remain unclear...
  13. Sun Z, Fan Q, Wang X, Guo Y, Wang H, Dong X. High stocking density alters bone-related calcium and phosphorus metabolism by changing intestinal absorption in broiler chickens. Poult Sci. 2017;: pubmed publisher
    ..70% or 0.90%) and NPP (0.28% or 0.36%) content at 1 of 2 stocking densities [28.6 (LSD, 13 broilers/m2) and 39.6 (HSD, 18 broilers/m2) kg of predicted final BW/m2 floor space], according to a 2 × 2 × 2 factorial design with 6 ..
  14. Tixi Verdugo W, Contreras Ramos J, Sicilia Argumedo G, German M, Fernandez Mejia C. Effects of Biotin Supplementation During the First Week Postweaning Increases Pancreatic Islet Area, Beta-Cell Proportion, Islets Number, and Beta-Cell Proliferation. J Med Food. 2017;: pubmed publisher
    ..Female BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 1 week after weaning...
  15. Hwang C, Chang P, Wang T. Contribution of remote substrate binding energy to the enzymatic rate acceleration for 3?-hydroxysteroid dehydrogenase/carbonyl reductase. Chem Biol Interact. 2017;276:133-140 pubmed publisher
    3?-Hydroxysteroid dehydrogenase/carbonyl reductase (3?-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH...
  16. Marques I, Alfaro M, Cruz N, Mesquita M, Takoudis C, Sukotjo C, et al. Tribocorrosion behavior of biofunctional titanium oxide films produced by micro-arc oxidation: Synergism and mechanisms. J Mech Behav Biomed Mater. 2016;60:8-21 pubmed publisher
    ..ANOVA and Tukey?s HSD tests were used (?=0.05). Biofunctional porous oxide layers were obtained...
  17. Arita S, Suzuki M, Kazama Koide M, Shinkai K. Shear bond strengths of tooth coating materials including the experimental materials contained various amounts of multi-ion releasing fillers and their effects for preventing dentin demineralization. Odontology. 2017;: pubmed publisher
    ..ANOVA and Tukey's HSD test were used for statistical analysis...
  18. Priyadarshini -, Lal B. Seasonal ovarian immunolocalization of neuropeptide Y and its role in steriodogenesis in Asian catfish, Clarias batrachus. Gen Comp Endocrinol. 2018;255:32-39 pubmed publisher
    ..and the ovarian levels of 17?-estradiol, testosterone, and activities of 3?-hydroxysteroid dehydrogenase (3?-HSD) and 17?-hydroxysteroid dehydrogenase (17?-HSD) in the ovary...
  19. Ren Y, Wen H, Li Y, Li J, He F, Ni M. Effects of stocking density on lipid deposition and expression of lipid-related genes in Amur sturgeon (Acipenser schrenckii). Fish Physiol Biochem. 2017;43:1707-1720 pubmed publisher
    ..5 kg/m3, MSD 8.0 kg/m3, and HSD 11...
  20. Yao X, Zhang G, Guo Y, Ei Samahy M, Wang S, Wan Y, et al. Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells. Theriogenology. 2017;102:162-173 pubmed publisher
    ..GCs caused an increase in VDR and in steroidogenic acute regulator (StAR) and 3?-hydroxysteroid dehydrogenase (3?-HSD) mRNA expression...
  21. Pinto Fochi M, Pytlowanciv E, Reame V, Rafacho A, Ribeiro D, Taboga S, et al. A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells. Reproduction. 2016;152:795-808 pubmed
    ..index, hyperleptinemia, reduced testosterone and estradiol testicular levels, and decreased testicular 17?-HSD enzyme . Morphometrical analyses indicated atrophy of Leydig cells in the O2 group...
  22. Filgo A, Foley J, Puvanesarajah S, Borde A, Midkiff B, Reed C, et al. Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat. Toxicol Pathol. 2016;44:1034-58 pubmed publisher
    There are currently no reports describing mammary gland development in the Harlan Sprague-Dawley (HSD) rat, the current strain of choice for National Toxicology Program (NTP) testing...
  23. Tsutsumi K, Shimakawa H, Kitagawa H, Sugahara K. Functional expression and genomic structure of human chondroitin 6-sulfotransferase. FEBS Lett. 1998;441:235-41 pubmed
    The cDNA and gene encoding human chondroitin 6-sulfotransferase (C6ST) have been cloned...
  24. Liebermann A, Roos M, Stawarczyk B. The Effect of Different Storage Media on Color Stability of Self-Adhesive Composite Resin Cements for up to One Year. Materials (Basel). 2017;10: pubmed publisher
    ..Data were analyzed using Kolmogorov-Smirnov, partial-eta-squared/?P², 3-/1-way ANOVA with Tukey-HSD post-hoc test (? = 0.05). Significant differences occurred between all SACRCs for WA (p ? 0...
  25. Bernstein H, Compans R. Sulfation of the human immunodeficiency virus envelope glycoprotein. J Virol. 1992;66:6953-9 pubmed
    ..Sulfation is a major determinant of negative charge and could play a role in biological functions and antigenic properties of HIV glycoproteins. ..
  26. Beck N, Balanay J, Johnson T. Assessment of occupational exposure to heat stress and solar ultraviolet radiation among groundskeepers in an eastern North Carolina university setting. J Occup Environ Hyg. 2017;: pubmed publisher
    ..was conducted using descriptive statistics, analysis of variance (ANOVA), Tukey Honestly Significant Difference (HSD) and Pearson Correlation tests. The mean (±SD) WBGT index was the highest in the afternoon (25.4±5...
  27. Kanimozhi V, Palanivel K, Akbarsha M, Kadalmani B. Molecular Mechanisms of Tributyltin-Induced Alterations in Cholesterol Homeostasis and Steroidogenesis in Hamster Testis: In Vivo and In Vitro Studies. J Cell Biochem. 2017;: pubmed publisher
    ..Changes in testis morphology, immunohistochemistry of iNOS, 3?-HSD and 17?-HSD, cholesterol transport receptor, nuclear receptors, and transcription factors were analyzed...
  28. Poluzzi E, Diemberger I, De Ridder M, Koci A, Clo M, Oteri A, et al. Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project. Eur J Clin Pharmacol. 2017;73:1499-1510 pubmed publisher
    ..Data on 1997-2010 were retrieved from seven healthcare databases: AARHUS (Denmark), GEPARD (Germany), HSD and ERD (Italy), PHARMO and IPCI (Netherlands) and THIN (UK)...
  29. Altinci P, Mutluay M, Tezvergil Mutluay A. Repair bond strength of nanohybrid composite resins with a universal adhesive. Acta Biomater Odontol Scand. 2018;4:10-19 pubmed publisher
    ..Data were analyzed with ANOVA and Tukey's HSD tests (p?=?.05)...
  30. Waryah A, Shahzad M, Shaikh H, Sheikh S, Channa N, Hufnagel R, et al. A novel CHST3 allele associated with spondyloepiphyseal dysplasia and hearing loss in Pakistani kindred. Clin Genet. 2016;90:90-5 pubmed publisher
    ..802G>T; p.Glu268*) in CHST3 associated with the phenotype. CHST3 encodes a chondroitin 6-O-sulfotransferase-1 (C6ST-1) enzyme that is essential for the sulfation of proteoglycans found in cartilages...
  31. Yang S, Chen D, Chen F, Zhao X, Zhang Y, Li Z, et al. Deletion of protein kinase B2 preserves cardiac function by blocking interleukin-6-mediated injury and restores blood pressure during angiotensin II/high-salt-diet-induced hypertension. J Hypertens. 2017;: pubmed publisher
    ..Therefore, we sought to determine whether the deletion of AKT2 protects cardiac function during angiotensin II/high-salt-diet (AngII/HSD) treatment and find out the signaling pathway.
  32. Ye X, Wang H, Kan J, Li J, Huang T, Xiong G, et al. A novel 17?-hydroxysteroid dehydrogenase in Rhodococcus sp. P14 for transforming 17?-estradiol to estrone. Chem Biol Interact. 2017;276:105-112 pubmed publisher
    17?-hydroxysteroid dehydrogenases (17?-HSD) are a group of oxidoreductase enzymes that exhibit high specificity for 17C reduction/oxidation...
  33. Bird A, Greatorex S, Reser D, Lavery G, Cole T. Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary-gonadal axis of primates. Endocr Connect. 2017;6:489-499 pubmed publisher
    ..activity and function of 11?-HSDs is thought to be understood, there exists an open reading frame for a distinct 11?HSD-like gene; HSD11B1L, which is present in human, non-human primate, sheep, pig and many other higher ..
  34. Xing W, Chen X, Ren D, Zhan K, Wang Y. The effect of ceramic thickness and resin cement shades on the color matching of ceramic veneers in discolored teeth. Odontology. 2017;: pubmed publisher
    ..50-mm-thick ceramic veneers that exhibited higher ?E values compared with veneers that were 0.75-mm thick. Tukey's HSD test showed that the average ?E values in body region were significantly smaller than that in cervical and incisal ..
  35. Zhang Q, Chen Z, Chen S, Xu Y, Deng H. Intraindividual stability of cortisol and cortisone and the ratio of cortisol to cortisone in saliva, urine and hair. Steroids. 2017;118:61-67 pubmed publisher
    ..reliably assess the activity of hypothalamic-pituitary-adrenal (HPA) axis and 11?-hydroxysteroid dehydrogenase (11?-HSD). One key issue is whether these biomarkers have intraindividual relative stability...
  36. Unger S, Lausch E, Rossi A, Megarbane A, Sillence D, Alcausin M, et al. Phenotypic features of carbohydrate sulfotransferase 3 (CHST3) deficiency in 24 patients: congenital dislocations and vertebral changes as principal diagnostic features. Am J Med Genet A. 2010;152A:2543-9 pubmed publisher
    We recently reported on the deficiency of carbohydrate sulfotransferase 3 (CHST3; chondroitin-6-sulfotransferase) in six subjects diagnosed with recessive Larsen syndrome or humero-spinal dysostosis [Hermanns et al...
  37. Guo X, Qiu W, Liu Y, Zhang Y, Zhao H, Chen J. Effects of Refined Xiaoyaosan on Depressive-Like Behaviors in Rats with Chronic Unpredictable Mild Stress through Neurosteroids, Their Synthesis and Metabolic Enzymes. Molecules. 2017;22: pubmed publisher
    ..The mRNA expressions of 3?-hydroxysteroid dehydrogenase (3?-HSD), 3?-hydroxysteroid dehydrogenase (3?-HSD), cholesterol side-chain cleavage enzyme (P450scc) and 5?-reductase (5a-R)..
  38. Struss W, Tan Z, Zachkani P, Moskalev I, Jackson J, Shademani A, et al. Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study. Prostate. 2017;77:1356-1365 pubmed publisher
    ..Post hoc Tukey HSD test results showed that the mean tumor growth rate of our device cohort was significantly lower than SC and ..
  39. Al Thobity A, Al Khalifa K, Gad M, Al Hariri M, Ali A, Alnassar T. In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..A multivariate analysis of variance (MANOVA) and the post-hoc Tukey's Honestly Significant Difference (HSD) test were performed to compare the difference of means between the observations taken at various intervals with ..
  40. Kubo M, Komada W, Otake S, Inagaki T, Omori S, Miura H. The effect of glass fiber posts and ribbons on the fracture strength of teeth with flared root canals restored using composite resin post and cores. J Prosthodont Res. 2018;62:97-103 pubmed publisher
    ..Average fracture loads were compared with a one-way ANOVA and Tukey HSD test (?=.05)...
  41. Shahin S, Singh S, Chaturvedi C. Mobile phone (1800MHz) radiation impairs female reproduction in mice, Mus musculus, through stress induced inhibition of ovarian and uterine activity. Reprod Toxicol. 2017;73:41-60 pubmed publisher
    ..levels of pituitary gonadotrophins (LH, FSH), sex steroids (E2 and P4) and expression of SF-1, StAR, P-450scc, 3?-HSD, 17?-HSD, cytochrome P-450 aromatase, ER-? and ER-? were observed in all the exposed groups of mice, compared to ..
  42. Sánchez Mendoza M, López Lorenzo Y, Matus Meza A, Arrieta J. Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls. Drug Dev Res. 2017;: pubmed publisher
    ..5?±?7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11?-hydroxysteroid dehydrogenase (11?-HSD) inhibitor administered at 30 mg kg-1 showed 63.5?±?9.4% gastroprotection...
  43. Verma H, Singh S. An insight into the possible mechanisms of antispermatogenic action of Dalbergia sissoo in male mice. Andrologia. 2017;: pubmed publisher
    ..weight day-1 for 35 days) and various testicular indices such 3?- and 17?-hydroxysteroid dehydrogenase (HSD) activities, Western blot analyses of StAR, cytochrome P450scc and caspase-3, germ cell apoptosis by TUNEL, and ..
  44. Srivastava P, Pandey H, Agarwal D, Mandal K, Phadke S. Spondyloepiphyseal dysplasia Omani type: CHST3 mutation spectrum and phenotypes in three Indian families. Am J Med Genet A. 2017;173:163-168 pubmed publisher
    ..CHST3 gene encodes the enzyme chondroitin 6-O-sulfotransferase-1 (C6ST-1) which mediates the sulfation of proteoglycans, (chondroitin sulfate), in the extracellular matrix of cartilage...
  45. Tuysuz B, Mizumoto S, Sugahara K, Celebi A, Mundlos S, Turkmen S. Omani-type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3. Clin Genet. 2009;75:375-83 pubmed publisher
    ..Mutation analysis in CHST3, the gene encoding for the chondroitin 6-O-sulfotransferase-1 (C6ST-1), revealed a homozygous missense mutation (T141M) in exon 3 in all three affected members of the family...
  46. Niemuth N, Klaper R. Low-dose metformin exposure causes changes in expression of endocrine disruption-associated genes. Aquat Toxicol. 2017;195:33-40 pubmed publisher
    ..6?±?0.9-fold), 3?-HSD (3.9?±?0.8-fold), 17?-HSD (17?±?4-fold), CYP19A1 (40?±?20-fold), and SULT2A1 (2.3?±?0...
  47. Lazo de la Vega Monroy M, Larrieta E, Tixi Verdugo W, Ramírez Mondragón R, Hernández Araiza I, German M, et al. Effects of dietary biotin supplementation on glucagon production, secretion, and action. Nutrition. 2017;43-44:47-53 pubmed publisher
    ..Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet (1.76 or 97.7 mg biotin/kg diet) for 8 wk postweaning...
  48. Miyata S, Komatsu Y, Yoshimura Y, Taya C, Kitagawa H. Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat Neurosci. 2012;15:414-22, S1-2 pubmed publisher
    ..Our results indicate that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons. ..
  49. Ding J, Li Z, Feng T, Liu J. A new cadinane sesquiterpenoid from cultures of the Basidiomycete Panus conchatus. Nat Prod Res. 2017;:1-5 pubmed publisher
    ..Compound 1 was tested for its cytotoxicity against five human cancer cell lines and for its inhibitory activity against isozymes of 11?-hydroxysteroid dehydrogenases (11?-HSD).
  50. Kitagawa H, Tsutsumi K, Ikegami Kuzuhara A, Nadanaka S, Goto F, Ogawa T, et al. Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008;283:27438-43 pubmed publisher
    ..267, 6027-6035). In this study, we investigated whether a recombinant human chondroitin 6-sulfotransferase-1 (C6ST-1) catalyzes the sulfation of C6 on both galactose residues in the linkage region using structurally defined ..
  51. Vernet Maury E, Alaoui Ismaïli O, Dittmar A, Delhomme G, Chanel J. Basic emotions induced by odorants: a new approach based on autonomic pattern results. J Auton Nerv Syst. 1999;75:176-83 pubmed
    ..Two-by-two odorant comparisons for autonomic responses using Tukey's HSD multiple comparison test only permitted differentiation between 'pleasant' and 'unpleasant' odors...
  52. Ahmad S, Khan M, Parvez S, Akhtar M, Raisuddin S. Molecular docking reveals the potential of phthalate esters to inhibit the enzymes of the glucocorticoid biosynthesis pathway. J Appl Toxicol. 2017;37:265-277 pubmed publisher
    ..enzymes of the GC biosynthesis pathway (GBP) such as CYP11A1, CYP11B2, CYP19A1, CYP17A1, CYP21A2 and 3?/20?-HSD. Binding affinities of the PAEs were compared with known inhibitors of these enzymes...
  53. Brüggemann M, Licht O, Fetter E, Teigeler M, Schäfers C, Eilebrecht E. KNOTTING NETS-MOLECULAR JUNCTIONS OF INTERCONNECTING ENDOCRINE AXES IDENTIFIED BY APPLICATION OF THE ADVERSE OUTCOME PATHWAY (AOP) CONCEPT. Environ Toxicol Chem. 2017;: pubmed publisher
    ..aromatase activity, and altered expression and function of the proteins 11?-hydroxysteroid dehydrogenase (11?-HSD) and steroidogenic acute regulatory (StAR) protein...
  54. Gao X, Sun L, Zhang N, Li C, Zhang J, Xiao Z, et al. Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring. Toxins (Basel). 2017;9: pubmed publisher
    ..with the inhibited mRNA and protein levels of oestrogen receptor-alpha (Esr1) and 3?-hydroxysteroid dehydrogenase (HSD) in the adult uterus and/or ovaries...
  55. Swizdor A, Panek A, Milecka Tronina N. Hydroxylative activity of Aspergillus niger towards androst-4-ene and androst-5-ene steroids. Steroids. 2017;126:101-106 pubmed publisher
    ..that incubated 5-ene steroids underwent bioconversion within two metabolic pathways: oxidation by the action of 3?-HSD (3?-hydroxysteroid dehydrogenase) to 4-ene steroids, and minor allylic hydroxylation to epimeric 7-alcohols...
  56. Emanuelsson I, Almokhtar M, Wikvall K, Grönbladh A, Nylander E, Svensson A, et al. Expression and regulation of CYP17A1 and 3?-hydroxysteroid dehydrogenase in cells of the nervous system: Potential effects of vitamin D on brain steroidogenesis. Neurochem Int. 2017;113:46-55 pubmed publisher
    ..of different cell types in the nervous system for expression of CYP17A1 and 3?-hydroxysteroid dehydrogenase (3?-HSD). 3?-HSD is important in all basic steroidogenic pathways and CYP17A1 is required to form sex hormones...
  57. Hassan H, Mazen I, Gad Y, Ali O, Mekkawy M, Essawi M. Mutational Profile of 10 Afflicted Egyptian Families with 17-?-HSD-3 Deficiency. Sex Dev. 2016;10:66-73 pubmed publisher
    ..at the detection of HSD17B3 gene mutations in Egyptian patients with suspected diagnosis of 46,XY DSD due to 17-?-HSD-3 deficiency and at evaluation of phenotype/genotype relationship of these mutations...
  58. Bossi G, Giordano G, Rispoli G, Maggiore G, Naturale M, Marchetti D, et al. Atypical clinical presentation and successful treatment with oral cholic acid of a child with defective bile acid synthesis due to a novel mutation in the HSD3B7 gene. Pediatr Rep. 2017;9:7266 pubmed publisher
    ..cholic acid in one Italian male child affected by 3?-hydroxy-?5-C27-steroid dehydrogenase (3?-HSD) deficiency...
  59. Araújo I, Prado C, Raposo L, Soares C, Zanatta R, Torres C, et al. Influence of Hemostatic Solution on Bond Strength and Physicochemical Properties of Resin Cement. Braz Dent J. 2017;28:624-631 pubmed publisher
    ..The mean values, except for the elemental chemical evaluation and failure mode, were evaluated by ANOVA and Tukey's HSD test. The color stability was influenced by storage time (p<0...
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    ..AD) to give testosterone (TS) as the sole product by the constitutive 17?-hydroxysteroid dehydrogenase (17?-HSD). The optimal conditions for the reduction were pH 8...
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    ..the colon, glucocorticoid metabolism is regulated by the isoenzymes of 11ß-hydroxysteroid dehydrogenase (11?-HSD)...