chondroitin 6 sulfotransferase

Summary

Gene Symbol: chondroitin 6 sulfotransferase
Description: carbohydrate sulfotransferase 3
Alias: C6ST, C6ST1, HSD, carbohydrate sulfotransferase 3, C6ST-1, GST-0, carbohydrate (chondroitin 6) sulfotransferase 3, chondroitin 6 sulfotransferase 1, chondroitin 6-O-sulfotransferase 1, galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Species: human

Top Publications

  1. Takahashi N, Harada M, Hirota Y, Zhao L, Azhary J, Yoshino O, et al. A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women. Endocrinology. 2017;158:84-97 pubmed publisher
    ..hCG-stimulated expression of steroidogenic acute regulatory protein (StAR) and 3?-hydroxysteroid dehydrogenase (3?-HSD) messenger RNAs (mRNAs) without affecting expression of cytochrome P450 cholesterol side-chain cleavage enzyme (..
  2. Baker M, Nelson D, Studer R. Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors. J Steroid Biochem Mol Biol. 2015;151:12-24 pubmed publisher
    ..Amphioxus contains CYP11, CYP17, CYP19, 3β/Δ5-4-HSD and 17β-HSD14, which suffice for the synthesis of estradiol and Δ5-androstenediol...
  3. Sharma P, Aslam Khan I, Singh R. Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes. Int J Fertil Steril. 2018;12:72-80 pubmed publisher
    ..3β-hydroxyl steroid dehydrogenase (3β-HSD) and 17β-HSD, non-enzymatic antioxidant glutathione (GSH) and enzymatic antioxidants viz...
  4. Mizutani T, Ishikane S, Kawabe S, Umezawa A, Miyamoto K. Transcriptional regulation of genes related to progesterone production. Endocr J. 2015;62:757-63 pubmed publisher
    ..side-chain cleavage enzyme (P450scc), and 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) are well-known proteins essential for progesterone production...
  5. Verma R, Krishna A. Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study. Gen Comp Endocrinol. 2017;241:57-68 pubmed publisher
    ..proteases; caspase-3), steroidogenic (side chain cleavage; SCC, 3β-hydroxy steroid dehydrogenase enzyme; 3β HSD, steroidogenic acute regulatory protein; StAR, aromatase and luteinizing hormone receptor; LH-R) markers, glucose ..
  6. Bird A, Greatorex S, Reser D, Lavery G, Cole T. Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary-gonadal axis of primates. Endocr Connect. 2017;6:489-499 pubmed publisher
    ..activity and function of 11?-HSDs is thought to be understood, there exists an open reading frame for a distinct 11?HSD-like gene; HSD11B1L, which is present in human, non-human primate, sheep, pig and many other higher ..
  7. Alkhedaide A, Alshehri Z, Sabry A, Abdel Ghaffar T, Soliman M, Attia H. Protective effect of grape seed extract against cadmium-induced testicular dysfunction. Mol Med Rep. 2016;13:3101-9 pubmed publisher
    ..side‑chain cleavage enzyme, cytochrome P450 17A1, 3β‑hydroxysteroid dehydrogenase (3β‑HSD), 17β‑HSD, androgen receptor, steroidogenic acute regulatory protein, and follicle‑stimulating ..
  8. Hassan Smith Z, Morgan S, Sherlock M, Hughes B, Taylor A, Lavery G, et al. Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging. J Clin Endocrinol Metab. 2015;100:2673-81 pubmed publisher
    ..40; P = .009). No differences in expression of 11β-HSD type 2, glucocorticoid receptor, or hexose-6-phosphate dehydrogenase between age groups were observed in either sex...
  9. Tan X, Ji C, Zheng L, Zhang J, Yuan H, Gong S, et al. Corticotrophin-releasing hormone and corticosterone impair development of preimplantation embryos by inducing oviductal cell apoptosis via activating the Fas system: an in vitro study. Hum Reprod. 2017;32:1583-1597 pubmed publisher
    ..and expression of CRH receptor 1 (CRHR1), glucocorticoid receptor (GR), Fas and 11?-hydroxysteroid dehydrogenase (HSD) were observed in embryos recovered at different times of in vitro culture...

More Information

Publications148 found, 100 shown here

  1. Jallouli M, El Bini Dhouib I, Dhouib H, Lasram M, Gharbi N, El Fazaa S. Disruption of steroidogenesis after dimethoate exposure and efficacy of N-acetylcysteine in rats: an old drug with new approaches. Environ Sci Pollut Res Int. 2016;23:7975-84 pubmed publisher
    ..steroidogenic acute regulatory StAR protein, cytochrome P450scc, 3β-hydroxysteroid dehydrogenase (3β-HSD), and 17β hydroxysteroid dehydrogenase (17β-HSD) in the testis after DMT exposure...
  2. Ecker A, Gonzaga T, Seeger R, Santos M, Loreto J, Boligon A, et al. High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster: Protective role of Syzygium cumini and Bauhinia forficata. Biomed Pharmacother. 2017;89:605-616 pubmed publisher
    ..Here, the fruit fly was used to evaluate the detrimental effects caused by consumption of high-sucrose diets (HSD), namely phenotypic responses linked to insulin signaling and oxidative stress...
  3. Terao M, Katayama I. Local cortisol/corticosterone activation in skin physiology and pathology. J Dermatol Sci. 2016;84:11-16 pubmed publisher
    ..11-DHC) into active cortisol/corticosterone in cells is 11?-hydroxysteroid dehydrogenase (11?-HSD)...
  4. De Michele F, Poels J, Weerens L, Petit C, Evrard Z, Ambroise J, et al. Preserved seminiferous tubule integrity with spermatogonial survival and induction of Sertoli and Leydig cell maturation after long-term organotypic culture of prepubertal human testicular tissue. Hum Reprod. 2017;32:32-45 pubmed
    ..was determined by testosterone levels in supernatants and by 3β-hydroxysteroid dehydrogenase (3β-HSD) IHC...
  5. Heier E, Meier A, Julich Haertel H, Djudjaj S, Rau M, Tschernig T, et al. Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. J Hepatol. 2017;66:1241-1250 pubmed publisher
    ..towards steatohepatitis was analysed using multicolor FACS analyses, cytokine and qPCR array in high sucrose diet (HSD) and methionine and choline deficient diet (MCD) fed wild-type and basic leucine zipper transcription factor, ATF-..
  6. Sheweita S, Al Shora S, Hassan M. Effects of benzo[a]pyrene as an environmental pollutant and two natural antioxidants on biomarkers of reproductive dysfunction in male rats. Environ Sci Pollut Res Int. 2016;23:17226-35 pubmed publisher
    ..enzymes including CYP17A1 and CP19A1, and decreased the activity of 17-? hydroxysteroid dehydrogenase (17?-HSD)...
  7. Saunders D, Podaima M, Codling G, Giesy J, Wiseman S. A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka. Aquat Toxicol. 2015;158:14-21 pubmed publisher
    ..synthesis of cholesterol (HMGR), transport of cholesterol (HDLR), and sex hormone steroidogenesis (CYP 17 and 3β-HSD) were significantly lesser in male medaka, which might have implications for concentrations of sex hormones...
  8. Reshma R, Mishra S, Thakur N, Parmar M, Somal A, Bharti M, et al. Modulatory role of leptin on ovarian functions in water buffalo (Bubalus bubalis). Theriogenology. 2016;86:1720-39 pubmed publisher
    ..protein (STARD1), cytochrome P450 cholesterol side-chain cleavage (CYP11A1), 3?-hydroxysteroid dehydrogenase (3?-HSD), cytochrome P450 aromatase (CYP19A1), sterol regulatory element-binding protein 1 (SREBP1), steroidogenic factor-1 ..
  9. Wen L, Jiang X, Sun J, Li X, Li X, Tian L, et al. Cyanidin-3-O-glucoside promotes the biosynthesis of progesterone through the protection of mitochondrial function in Pb-exposed rat leydig cells. Food Chem Toxicol. 2018;112:427-434 pubmed publisher
    ..of the steroidogenic enzymes steroidogenic acute regulatory protein (StAR), 3?-hydroxysteroid dehydrogenase (3?-HSD) and cytochrome P450 enzyme cholesterol side chain cleavage enzyme (CYP11A1)...
  10. Sun S, Wang J, Lu Y, Dai J. Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis. Arch Toxicol. 2018;92:2013-2025 pubmed publisher
    ..cleavage enzyme (CYP11A1), 17?-hydroxylase/17,20 lyase (CYP17A1), and 3?-hydroxysteroid dehydrogenase (3?-HSD), which may be the mechanism behind increased progesterone...
  11. Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, et al. Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein. Endocrinology. 2017;158:2648-2658 pubmed publisher
    ..Other steroidogenic enzymes, including CYP11A1, 3?-HSD, and CYP17A1, were not decreased...
  12. Kadry M, Megeed R. Probiotics as a Complementary Therapy in the Model of Cadmium Chloride Toxicity: Crosstalk of ?-Catenin, BDNF, and StAR Signaling Pathways. Biol Trace Elem Res. 2018;185:404-413 pubmed publisher
    ..level in addition to steroidogenic acute regulatory protein (StAR) and 17-hydroxy steroid dehydrogenase (17-? HSD) gene expression...
  13. Zhao J, Zhao Y, Zhu W. A high-fat, high-protein diet attenuates the negative impact of casein-induced chronic inflammation on testicular steroidogenesis and sperm parameters in adult mice. Gen Comp Endocrinol. 2017;252:48-59 pubmed publisher
    ..compared with the control, whereas testicular mRNA and protein levels of 3?-hydroxysteroid dehydrogenase (3?-HSD) in groups HFPD+SI and HFPD+CS significantly increased...
  14. Sarkar D, Singh S. Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THR?1). Gen Comp Endocrinol. 2017;251:109-120 pubmed publisher
    ..blot analyses also showed reductions in both testicular mRNA and protein levels of SF-1, StAR, CYP11A1 and 3?-HSD in these mice...
  15. Yao X, Zhang G, Guo Y, Ei Samahy M, Wang S, Wan Y, et al. Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells. Theriogenology. 2017;102:162-173 pubmed publisher
    ..GCs caused an increase in VDR and in steroidogenic acute regulator (StAR) and 3?-hydroxysteroid dehydrogenase (3?-HSD) mRNA expression...
  16. Zhou X, Wang J, Sheng N, Cui R, Deng Y, Dai J. Subchronic reproductive effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFAES), an alternative to PFOS, on adult male mice. J Hazard Mater. 2018;358:256-264 pubmed publisher
    ..were also detected using Western blotting, and included steroidogenic proteins, STAR, CYP11A1, CYP17A1, and 3?-HSD and cell junction proteins, occludin, ?-catenin, and connexin 43; however, none were changed after 6:2 Cl-PFAES ..
  17. Lobo M, Arenas M, Huerta L, Sacristán S, Pérez Crespo M, Gutiérrez Adán A, et al. Liver growth factor induces testicular regeneration in EDS-treated rats and increases protein levels of class B scavenger receptors. Am J Physiol Endocrinol Metab. 2015;308:E111-21 pubmed publisher
    ..in cholesterol metabolism, such as hormone sensitive lipase (HSL), 3β-hydroxysteroid dehydrogenase (3β-HSD), scavenger receptor SR-BI, and other components of the SR family that could contribute to the recovery of ..
  18. Davé A, Krishna A, Tsutsui K. Direct effects of RFRP-1, a mammalian GnIH ortholog, on ovarian activities of the cyclic mouse. Gen Comp Endocrinol. 2017;252:193-199 pubmed publisher
    ..such as steroidogenic markers (luteinizing hormone receptors; LH-R and 3?-hydroxysteroid dehydrogenase; 3?-HSD), apoptotic markers [Poly(ADP-ribose) polymerase-1; PARP-1 and cysteine-aspartic protease; caspase-3], a cell ..
  19. Patnode M, Cheng C, Chou C, Singer M, Elin M, Uchimura K, et al. Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013;288:26533-45 pubmed publisher
    ..Gal6S, namely keratan sulfate galactose 6-O-sulfotransferase (KSGal6ST) and chondroitin 6-O-sulfotransferase 1 (C6ST-1)...
  20. Oh G, Yoon J, Lee G, Kwak J, Kim S. The Hexane Fraction of cyperus rotundus Prevents Non-Alcoholic Fatty Liver Disease Through the Inhibition of Liver X Receptor α-Mediated Activation of Sterol Regulatory Element Binding Protein-1c. Am J Chin Med. 2015;43:477-94 pubmed publisher
    ..ameliorated fatty liver disease and reduced the expression levels of hepatic lipogenic genes in high sucrose diet (HSD)-fed mice...
  21. Kilic S, Kolukcu E, Erdemir F, Benli I, Arıcı A. The Effects of Oral 5-alpha Reductase Inhibitors on Penile Intracavernosal Pressures and Penile Morphology in Rat Model. Urol J. 2018;: pubmed publisher
    ..05 was accepted as the level of statistical significance. For two group comparisons Tukey HSD test was used as post hoc test of one way analysis of variance...
  22. Scaia M, Volonteri M, Czuchlej S, Ceballos N. Estradiol and reproduction in the South American toad Rhinella arenarum (Amphibian, Anura). Gen Comp Endocrinol. 2018;: pubmed publisher
    ..protein levels or enzymatic activity, while it reduces 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD/I) activity during the post reproductive season...
  23. MacLeod A, Fallon P, Sharp S, Henderson C, Wolf C, Huang J. An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes. Mol Cell Proteomics. 2015;14:750-60 pubmed publisher
    ..2a, and glutathione S-transferases (Gst) m2 and m3, along with down-regulation of hydroxysteroid dehydrogenases (Hsd) 11b1 and 17b6...
  24. van den Driesche S, Walker M, McKinnell C, Scott H, Eddie S, Mitchell R, et al. Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents. PLoS ONE. 2012;7:e37064 pubmed publisher
    ..sites for SF-1 and COUP-TFII in their promoter regions, but does not affect an SF-1 dependent LC gene (3β-HSD) without overlapping sites...
  25. Torres Villalobos G, Hamdan Pérez N, Tovar A, Ordaz Nava G, Martínez Benítez B, Torre Villalvazo I, et al. Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model. Ann Hepatol. 2015;14:540-6 pubmed
    ..3) High-fat cornstarch diet (HFCO) + 5% sucrose in drinking water. 4) Chow diet + 20% sucrose in drinking water (HSD)...
  26. Miyata S, Kitagawa H. Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan. Neural Plast. 2016;2016:1305801 pubmed publisher
    ..Here we found that overexpression of chondroitin 6-sulfotransferase-1 (C6ST-1), which catalyzes 6-sulfation of CS chains, selectively decreased aggrecan, a major CSPG in PNNs, in the aged ..
  27. Altinok A, Yildirim S, Altug T, Sut N, Ober A, Ozsahin E, et al. Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study. Breast. 2016;28:174-7 pubmed publisher
    ..the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2...
  28. Pinelli L, Gimenes Olbera A, Candido L, Miotto L, Antonio S, Fais L. Effects of whitening dentifrice on yttria-stabilized tetragonal zirconia polycrystal surfaces after simulating brushing. J Prosthet Dent. 2017;117:158-163 pubmed publisher
    ..Baseline and posttreatment Ra were analyzed using the 1-way ANOVA and Tukey HSD multiple comparison test; the paired t test was used for intragroup comparison (all ?=.05)...
  29. Mandil R, Rahal A, Prakash A, Garg S, Gangwar N, Swain D. Ameliorative potential of ?-tocopherol against flubendiamide and copper-induced testicular-insult in Wistar rats. Chem Biol Interact. 2016;260:91-101 pubmed publisher
    ..ACP, ALP and SDH remain unaltered. Increase in LDH, ?-GT, abnormal sperm and reduced 17?-HSD, percent live and HOST +ve sperms and testosterone level was observed in all three exposed groups...
  30. Lampert C, Arcego D, de Sá Couto Pereira N, Dos Santos Vieira A, Toniazzo A, Krolow R, et al. Short post-weaning social isolation induces long-term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats. Int J Dev Neurosci. 2017;61:21-30 pubmed publisher
    ..the effects of a short post-weaning social isolation combined with a free access to a chronic high sugar diet (HSD) on the dopaminergic system, oxidative status and behavioral response to an amphetamine-like drug in adulthood...
  31. Torabi Ardakani M, Giti R, Taghva M, Javanmardi S. Effect of a zirconia primer on the push-out bond strength of zirconia ceramic posts to root canal dentin. J Prosthet Dent. 2015;114:398-402 pubmed publisher
    ..Three-way ANOVA and the Tukey HSD test was used to assess the effects of the zirconia primer, the 2 different resin luting cements, and different ..
  32. Funghi L, Damiani F, Yen C, Lee C, Lombardi A, Schatz F, et al. Expression and regulation of 11?-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia. Mol Cell Endocrinol. 2016;437:163-170 pubmed publisher
    ..Tissue concentration of active glucocorticoids depends on the expression of 11?-hydroxysteroid dehydrogenase (11?-HSD)...
  33. Chou C, Lin J, Hou H, Liu Y. Visualizing the Interrenal Steroidogenic Tissue and Its Vascular Microenvironment in Zebrafish. J Vis Exp. 2016;: pubmed publisher
    ..chromogenic histochemical staining of 3-β-Hydroxysteroid dehydrogenase /Δ5-4 isomerase (3β-Hsd) activity-positive cells is critical for monitoring the morphology and differentiation of adrenocortical and ..
  34. Raghavan A, Pottipalli Sathyanarayana H, Kailasam V, Padmanabhan S. Comparative evaluation of salivary bisphenol A levels in patients wearing vacuum-formed and Hawley retainers: An in-vivo study. Am J Orthod Dentofacial Orthop. 2017;151:471-476 pubmed publisher
    ..Statistical analyses were performed by using 2-way analysis of variance and post-hoc multiple-comparisons Tukey HSD tests. Statistically significant BPA levels in saliva were found for all groups (P ?0.05)...
  35. Lopes J, Grams S, da Silva E, de Medeiros L, de Brito C, Yamaguti W. Reference equations for handgrip strength: Normative values in young adult and middle-aged subjects. Clin Nutr. 2018;37:914-918 pubmed publisher
    ..HS was significantly higher for men compared to women, and also higher for the dominant hand (HSD) compared to the non-dominant hand (HSND) (p < 0.05)...
  36. Sun X, Kido T, Honma S, Koh E, Okamoto R, Manh H, et al. The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in Vietnamese men. Sci Total Environ. 2017;595:842-848 pubmed publisher
    ..Levels of testosterone, estradiol and 3?-hydroxysteroid dehydrogenase (3?-HSD) activity in the hotspot group were also significantly higher than in non-sprayed group...
  37. Tetsuka M, Takagi R, Ambo N, Myat T, Zempo Y, Onuma A. Glucocorticoid metabolism in the bovine cumulus-oocyte complex matured in vitro. Reproduction. 2016;151:73-82 pubmed publisher
    Glucocorticoid action in target organs is regulated by relative activities of 11β-HSD type 1 (HSD11B1) that mainly converts cortisone to active cortisol and type 2 (HSD11B2) that inactivates cortisol to cortisone...
  38. Dede D, Åžahin O, Koroglu A, Yilmaz B. Effect of sealant agents on the color stability and surface roughness of nanohybrid composite resins. J Prosthet Dent. 2016;116:119-28 pubmed publisher
    ..The data were statistically analyzed by 2-way ANOVA and by the Tukey HSD test (α=.05)...
  39. Lee A, Hsu C, Liu Y, Wei P, Chen J. Supermolecules of poly(N-isopropylacrylamide) complexating Herring sperm DNA with bio-multiple hydrogen bonding. Colloids Surf B Biointerfaces. 2016;148:422-430 pubmed publisher
    ..we used the poly(N-isopropylacrylamide) (PNIPAAm) as a medium to blend with an organic DNA, herring sperm DNA (HSD), to generate PNIPAAm-HSD supramolecular complexes...
  40. Ricci F, Masini F, Fossati B, Frascione P, De Waure C, Capizzi R, et al. Combination therapy with hydrogen peroxide (4%), salicylic acid (0.5%) and D-panthenol (4%): efficacy and skyn tolerability in common acne vulgaris during sun exposure period. Eur Rev Med Pharmacol Sci. 2016;20:232-6 pubmed
    ..5%) and D-panthenol (4%) (HSD) gel, in mild-moderate acne vulgaris, during the period of sun exposure...
  41. Adejumo O, Daniel O, Otesanya A, Adejumo E. Determinants of health system delay at public and private directly observed treatment, short course facilities in Lagos State, Nigeria: A cross-sectional study. Int J Mycobacteriol. 2016;5:257-264 pubmed publisher
    Despite several studies on health system delay (HSD) among tuberculosis (TB) patients in Nigeria, no study has compared HSD in private and public health facilities...
  42. Mohamad Asri S, Mohd Ramli E, Soelaiman I, Mat Noh M, Abdul Rashid A, Suhaimi F. Piper sarmentosum Effects on 11?-Hydroxysteroid Dehydrogenase Type 1 Enzyme in Serum and Bone in Rat Model of Glucocorticoid-Induced Osteoporosis. Molecules. 2016;21: pubmed
    ..between the effects of Ps leaf water extract with the regulation of 11?-hydroxysteroid dehydrogenase (HSD) type 1 enzyme activity in serum and bone of glucocorticoid-induced osteoporotic rats...
  43. Chowdhury I, Thomas K, Zeleznik A, Thompson W. Prohibitin regulates the FSH signaling pathway in rat granulosa cell differentiation. J Mol Endocrinol. 2016;56:325-36 pubmed publisher
    ..protein (StAR), p450 cholesterol side-chain cleavage enzyme (p450scc), 3?-hydroxysteroid dehydrogenase (3?-HSD), and aromatase (Cyp19a1); and decreased E2 and P4 synthesis and secretions in the presence of FSH stimulation...
  44. Cengiz Ã, Köksal B, Tatlı O, Sevim Ã, Ahsan U, Ãœner A, et al. Effect of dietary probiotic and high stocking density on the performance, carcass yield, gut microflora, and stress indicators of broilers. Poult Sci. 2015;94:2395-403 pubmed publisher
    ..Each treatment had 8 replicates of 15 chicks each. Two groups were subjected to a high stocking density (HSD) of 20 birds/m² and the other 2 groups were kept at low stocking density (LSD) of 10 birds/m²...
  45. Johnson J, Opiyo M, Thomson M, Gharbi K, Seckl J, Heger A, et al. 11?-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet. J Endocrinol. 2017;232:273-283 pubmed
    The enzyme 11?-hydroxysteroid dehydrogenase (11?-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms...
  46. Oktem O, Akin N, Bildik G, Yakin K, Alper E, Balaban B, et al. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Hum Reprod. 2017;32:643-652 pubmed publisher
    ..by up-regulating the expression and increasing enzymatic activity of 3β-hydroxysteriod dehydrogenoase (3β-HSD), which converts pregnenolone to P...
  47. Ristić N, Ajdžanović V, Manojlović Stojanoski M, Maliković J, Uscebrka G, Markovic Z, et al. Effects of Estradiol on Histological Parameters and Secretory Ability of Pituitary Mammotrophs in Ovariectomized Female Rats. Cell J. 2017;19:461-468 pubmed publisher
    ..between groups was performed using one-way analysis of variance (ANOVA) and Tukay (honest significant difference) HSD test. Ovariectomy caused significant (P<0...
  48. Matsumoto K, Imakawa K, Hayashi C. Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. BMC Pregnancy Childbirth. 2017;17:312 pubmed publisher
    ..in follicular fluids (FFs) are suggestive that aromatase and/or 17?-hydroxysteroid dehydrogenase (17?-HSD) could be low...
  49. Morris D. Why do humans have two glucocorticoids: A question of intestinal fortitude. Steroids. 2015;102:32-8 pubmed publisher
    ..In humans, these 5α-corticosterone metabolites are likely to influence blood pressure regulation and Na(+) retention by inhibiting the rate of deactivation of cortisol by 11β-HSD isoforms.
  50. Pham J, Will C, Mack V, Halbert M, Conner E, Bucholtz K, et al. Structure-function relationships for the selective inhibition of human 3?-hydroxysteroid dehydrogenase type 1 by a novel androgen analog. J Steroid Biochem Mol Biol. 2017;174:257-264 pubmed publisher
    ..In purified 3?-HSD inhibition studies, DiCN-AND competitively inhibited 3?- HSD1 with Ki=4...
  51. Ritschel F, Clas S, Geisler D, Haas V, Seidel M, Steding J, et al. Is hypercortisolism in anorexia nervosa detectable using hair samples?. J Psychiatr Res. 2017;98:87-94 pubmed publisher
    ..Given the drastic metabolic disturbances in acutely underweight AN our findings could be interpreted as disturbed cortisol incorporation or altered activity of 11-?-HSD-enzymes in the hair follicle.
  52. Yu Z, Wang T, Cui J, Song Y, Ma X, Su Y, et al. [Subcutaneous transplants of juvenile rat testicular tissues continue to develop and secret androgen in adult rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1652-1656 pubmed
    ..the grafts were examined by HE staining; the expression and distribution of hydroxysteroid 17-beta dehydrogenase 1 (HSD-17?1) were investigated by immunohistochemistry; and the serum androgen level was determined by ELISA...
  53. Lux L, Thompson G, Waliszewski K, Ziebert G. Comparison of the Kois Dento-Facial Analyzer System with an earbow for mounting a maxillary cast. J Prosthet Dent. 2015;114:432-9 pubmed publisher
    ..A randomized complete block design analysis of variance (RCBD) and post hoc tests (Tukey-Kramer HSD) (α=.05) were used to evaluate the occlusal plane angle and axis-central incisor distance...
  54. Zhu H, Qian Z, Liu H, Bao E. ACTH-induced stress in weaned sows impairs LH receptor expression and steroidogenesis capacity in the ovary. Reprod Biol Endocrinol. 2016;14:80 pubmed
    ..05) in the ACTH group than in the control group. The LHR, 3?-hydroxysteroid dehydrogenase (3?-HSD), cytochrome P450 aromatase (P450arom), and cytochrome P450 17a-hydroxylase (P450c17) mRNA levels were ..
  55. Ding H, Zheng W, Han H, Hu X, Hu B, Wang F, et al. Reproductive toxicity of linuron following gestational exposure in rats and underlying mechanisms. Toxicol Lett. 2017;266:49-55 pubmed publisher
    ..a significantly reduced expression of enzymes pertinent to the testosterone production including P450scc, 3?-HSD, and PCNA in Leydig cells (p<0.05)...
  56. Acosta D, Rivelli M, Skenandore C, Zhou Z, Keisler D, Luchini D, et al. Effects of rumen-protected methionine and choline supplementation on steroidogenic potential of the first postpartum dominant follicle and expression of immune mediators in Holstein cows. Theriogenology. 2017;96:1-9 pubmed publisher
    ..Gene expression of TLR4, TNF, IL1-β, IL8, IL6, LHCGR, STAR, 3β-HSD, P450scc, CYP19A1, IRS1, IGF, MAT1A, and SAHH, was measured in the follicular cells of the first DF...
  57. Fouad Mansour M, Pelletier M, Boulet M, Mayrand D, Brochu G, Lebel S, et al. Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2. Mol Cell Endocrinol. 2015;414:168-76 pubmed publisher
    Testosterone can be converted into androstenedione (4-dione) by 17β-hydroxysteroid dehydrogenase (HSD) activity likely performed by 17β-HSD type 2...
  58. İşyar M, Yilmaz I, Nusran G, Güler O, Yalcin S, Mahirogullari M. Safety of bioabsorbable implants in vitro. BMC Surg. 2015;15:127 pubmed publisher
    ..For the statistical evaluation of the data obtained in the present study, the groups were compared by Tukey HSD test following ANOVA. The significance level was set as p < 0.05...
  59. Habibyar A, Sharma N, Khurana N. PASS assisted prediction and pharmacological evaluation of hesperidin against scopolamine induced amnesia in mice. Eur J Pharmacol. 2016;789:385-394 pubmed publisher
    ..Among number of antioxidant compounds, hesperidin (HSD) was selected for this study on the basis of its reported antioxidant and neuroprotective effects...
  60. Dede D, ArmaÄŸanci A, Ceylan G, Celık E, Cankaya S, Yilmaz B. Influence of implant abutment material on the color of different ceramic crown systems. J Prosthet Dent. 2016;116:764-769 pubmed publisher
    ..The data were analyzed with 2-way analysis of variance (ANOVA) and compared with the Tukey HSD test (α=.05)...
  61. Liu P, Miao J, Song Y, Pan L, Yin P. Effects of 2,2',4,4'-tetrabromodipheny ether (BDE-47) on gonadogenesis of the manila clam Ruditapes philippinarum. Aquat Toxicol. 2017;193:178-186 pubmed publisher
    ..The mRNA expression of 3?-HSD in females exposed to BDE-47 was significantly decreased at day 5, while mRNA expression of 17?-HSD and CYP17 was ..
  62. Wen J, Pan L. Short-term exposure to benzo[a]pyrene disrupts reproductive endocrine status in the swimming crab Portunus trituberculatus. Comp Biochem Physiol C Toxicol Pharmacol. 2015;174-175:13-20 pubmed publisher
    ..concentrations in ovary and hemolymph, and (3) mRNA levels of genes involved in sex steroid synthesis (3β-HSD,17β-HSD) or reproduction (estrogen receptor (ER), OUT (Ovarian tumor gene) domain containing ubiquitin aldehyde-..
  63. Lian P, Li H, Zhang Y, Ji Z. [Effects of activity of 11β-hydroxysteroid dehydrogenase type 2 on serum potassium levels in Cushing's syndrome patients]. Zhonghua Yi Xue Za Zhi. 2015;95:929-32 pubmed
    ..It suggested that the deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD 2) was present in hypokalemic adults with hypercortisolism...
  64. Saker S, Özcan M. Retentive strength of fiber-reinforced composite posts with composite resin cores: Effect of remaining coronal structure and root canal dentin conditioning protocols. J Prosthet Dent. 2015;114:856-61 pubmed publisher
    ..Two-way ANOVA and the Tukey HSD post hoc test were used to analyze the data...
  65. Chu Q, Chi Z, Zhang X, Liang D, Wang X, Zhao Y, et al. A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells. Int J Mol Med. 2016;37:1619-26 pubmed publisher
    ..namely cholesterol side?chain cleavage enzyme (P450scc) and 3?-hydroxysteroid dehydrogenase/D5-D4 isomerase (3?-HSD) as well as decreased serum testosterone levels...
  66. Peralta O, Bucher D, Angulo C, Castro M, Ratto M, Concha I. Tissue localization of GM-CSF receptor in bovine ovarian follicles and its role on glucose uptake by mural granulosa cells. Anim Reprod Sci. 2016;170:157-69 pubmed publisher
    ..and ?-subunits of GM-CSF with follicle stimulating hormone receptor (FSHR) and 3?-hydroxysteroid dehydrogenase (3?-HSD), and the temporal associations with gene expression of hexose transporters (GLUTs) in granulosa cells of cattle ..
  67. Singh V, Lal B. Nitric oxide (NO) stimulates steroidogenesis and folliculogenesis in fish. Reproduction. 2017;153:133-146 pubmed
    ..vitellogenin contents in serum and ovary and activities of 5-ene-3β-hydroxysteroid dehydrogenases (3β-HSD) and 17β-hydroxysteroid dehydrogenases (17β-HSD) in ovary, whereas higher dose of SNP increased these ..
  68. da Silva E, de Sá Rodrigues C, de Oliveira Matos M, de Carvalho T, Dos Santos G, Amaral C. Experimental etch-and-rinse adhesive systems containing MMP-inhibitors: Physicochemical characterization and resin-dentin bonding stability. J Dent. 2015;43:1491-7 pubmed publisher
    ..Adper Single Bond 2 (SB2) was used as a commercial control. The data were analyzed using ANOVA and Tukey's HSD test. SB2 presented the highest DC% (p<0.05). CHX presented the lowest WS (p<0.05)...
  69. Graci V, Rabuffetti M, Frigo C, Ferrarin M. Is lower peripheral information weighted differently as a function of step number during step climbing?. Gait Posture. 2017;52:52-56 pubmed publisher
    ..Tukey's HSD test was used for post-hoc comparisons...
  70. Belani M, Shah P, Banker M, Gupta S. Dual effect of insulin resistance and cadmium on human granulosa cells - In vitro study. Toxicol Appl Pharmacol. 2016;313:119-130 pubmed publisher
    ..IR with 32?M Cd in granulosa cells demonstrated significant decrease in expression of StAR, CYP11A1, CYP19A1, 17?-HSD, 3?-HSD, FSH-R and LH-R...
  71. Adib S, Valojerdi M. Molecular assessment, characterization, and differentiation of theca stem cells imply the presence of mesenchymal and pluripotent stem cells in sheep ovarian theca layer. Res Vet Sci. 2017;114:378-387 pubmed publisher
    ..ALCs were positive for PPARα and LPL. TPCs expressed theca specific genes (GLI2, GLI3, PTCH1, CYP17A1, 3β-HSD and LHR) and secreted testosterone, dehydroepiandrostenedione (DHEA), androstenedione, progesterone and estradiol...
  72. Aziz N, Maxwell M, Brenner B. Coordinate regulation of 11 beta-HSD and Ke 6 genes in cpk mouse: implications for steroid metabolic defect in PKD. Am J Physiol. 1994;267:F791-7 pubmed
    ..6a protein to specific functional domains of the human and rat 11 beta-hydroxysteroid dehydrogenase enzyme (11 beta-HSD), which inactivates glucocorticoids, is substantial...
  73. t Hart L, Fritsche A, Nijpels G, van Leeuwen N, Donnelly L, Dekker J, et al. The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. Diabetes. 2013;62:3275-81 pubmed publisher
    ..Our data identify chymotrypsin in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment. ..
  74. Gopula B, Yang S, Kuo T, Hsieh J, Wu P, Henschke J, et al. Direct synthesis of chiral 3-arylsuccinimides by rhodium-catalyzed enantioselective conjugate addition of arylboronic acids to maleimides. Chemistry. 2015;21:11050-5 pubmed publisher
    ..Pyrrolidine 4, a biologically active compound, and pyrrolidine 5, an ent-precursor to an HSD-1 inhibitor, were synthesized to demonstrate the utility of this method.
  75. Chakraborty A, Mandal J, Mondal C, Sinha S, Chandra A. Effect of Excess Iodine on Oxidative Stress Markers, Steroidogenic-Enzyme Activities, Testicular Morphology, and Functions in Adult Male Rats. Biol Trace Elem Res. 2016;172:380-94 pubmed publisher
    ..imbalance in the pro-/antioxidant status inhibiting the activity of ∆(5) 3β- hydroxysteroid dehydrogenase (HSD) and 17β-HSD resulting to reduced synthesis of testosterone that causes structural and functional changes of the ..
  76. Azizi F, Shahidi Zandi V. Effect of different types of dental anchorage following first premolar extraction on mandibular third molar angulation. Int Orthod. 2018;16:82-90 pubmed publisher
    ..Third molar uprighting was significantly different among four groups using one-way ANOVA (P=0.004). Tukey (HSD: honestly significant difference) post hoc test indicated that difference in third molar angulation was ..
  77. Campos R, Soares P, Versluis A, de O Júnior O, Ambrosano G, Nunes I. Crown fracture: Failure load, stress distribution, and fractographic analysis. J Prosthet Dent. 2015;114:447-55 pubmed publisher
    ..Mean fracture loads from compressive tests were submitted to ANOVA and Tukey HSD test. Finite element and fractographic analyses were performed and associated with the fracture load and pattern...
  78. Das D, Nath P, Pal S, Hajra S, Ghosh P, Maitra S. Expression of two insulin receptor subtypes, insra and insrb, in zebrafish (Danio rerio) ovary and involvement of insulin action in ovarian function. Gen Comp Endocrinol. 2016;239:21-31 pubmed publisher
    ..of oocyte maturation was further manifested through up regulation of 20β-hydroxysteroid dehydrogenase (20β-hsd), MIS receptor (mPRα), insulin-like growth factor 3 (igf3) and IGF1 receptor (igf1rb), but not cyp19a expression ..
  79. Garay L, Gonzalez Giqueaux P, Guennoun R, Schumacher M, Gonzalez Deniselle M, De Nicola A. Progesterone treatment modulates mRNA OF neurosteroidogenic enzymes in a murine model of multiple sclerosis. J Steroid Biochem Mol Biol. 2017;165:421-429 pubmed publisher
    ..anion channel (VDAC), P450scc (cholesterol side-chain cleavage), 5?-reductase, 3?-hydroxysteroid dehydrogenase (3?-HSD) and aromatase, whereas levels of 3?-hydroxysteroid dehydrogenase (3?-HSD) showed a large intra-group variance...
  80. Antanasova M, Kocjan A, Kovac J, Zuzek B, Jevnikar P. Influence of thermo-mechanical cycling on porcelain bonding to cobalt-chromium and titanium dental alloys fabricated by casting, milling, and selective laser melting. J Prosthodont Res. 2018;62:184-194 pubmed publisher
    ..Data were analyzed using ANOVA, Tukey's HSD and t-tests (?=0.05). The SBS-means differed according to the metal-ceramic combination (p<0...
  81. Holbein W, Blackburn M, Andrade M, Toney G. Burst Patterning of Hypothalamic Paraventricular Nucleus-Driven Sympathetic Nerve Activity in Angiotensin II-Salt Hypertension. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00560.2017 pubmed publisher
    ..Here, integrated sSNA was elevated in AngII infused rats fed a high salt (2% NaCl) diet (AngII-HSD) compared to vehicle infused rats fed a normal salt (0.4% NaCl) diet (Veh-NSD) (P<0.01)...
  82. Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, et al. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. J Biochem. 2000;128:763-70 pubmed
    ..adenocarcinoma and peripheral blood leukocytes, whereas strong expression of human chondroitin 6-sulfotransferase (C6ST) is observed in aorta and testis...
  83. Gelberg L, Andersen R, Rico M, Vahidi M, Natera Rey G, Shoptaw S, et al. A pilot replication of QUIT, a randomized controlled trial of a brief intervention for reducing risky drug use, among Latino primary care patients. Drug Alcohol Depend. 2017;179:433-440 pubmed publisher
    ..Primary outcome was reduction in number of days of drug use in past 30days of the highest scoring drug (HSD) on the baseline ASSIST, from baseline to 3-month follow-up...
  84. Pavillard L, Cañadas Lozano D, Alcocer Gómez E, Marín Aguilar F, Pereira S, Robertson A, et al. NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget. 2017;8:99740-99756 pubmed publisher
    ..Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks...
  85. Horton J, Maass D, White J, Sanders B. Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes. Am J Physiol Heart Circ Physiol. 2001;280:H1591-601 pubmed
    Whereas hypertonic saline-dextran (HSD, 7.5% NaCl in 6% D70) improves cardiac contractile function after burn trauma, the mechanisms of HSD-related cardioprotection remain unclear...
  86. Searle C, Jewell R, Kraft J, Stoebe P, Chumas P, Titheradge H, et al. Craniosynostosis: a previously unreported association with CHST3-related skeletal dysplasia (autosomal recessive Larsen syndrome). Clin Dysmorphol. 2014;23:12-5 pubmed publisher
  87. Hatfield G, Charlton J, Cochrane C, Hammond C, Napier C, Takacs J, et al. The Biomechanical Demands on the Hip During Progressive Stepping Tasks. J Strength Cond Res. 2017;31:3444-3453 pubmed publisher
    ..and adduction moment impulses, and gluteus medius (GM) and quadriceps activity compared with half step-down (HSD) and SU...
  88. Givehchi S, Hemmativaghef E, Hoveidi H. Association between safety leading indicators and safety climate levels. J Safety Res. 2017;62:23-32 pubmed publisher
    ..38) to 2.98 in workers' safety priority and risk non-acceptance (SD=0.47). Tukey HSD tests indicated a statistically significant difference of mean scores among groups undergoing different number of ..
  89. Zang Z, Fang Y, Ji S, Gao Y, Zhu Y, Xia T, et al. Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J Sex Med. 2017;14:1297-1306 pubmed publisher
    ..regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme, and 3?-hydroxysteroid dehydrogenase (3?-HSD), also were decreased in the testes of mice exposed to formaldehyde...
  90. Konishi K, Ueda S, Kawano M, Osawa S, Tamura T, Hokazono E, et al. Characterization and application of a novel nicotinamide mononucleotide adenylyltransferase from Thermus thermophilus HB8. J Biosci Bioeng. 2018;125:385-389 pubmed publisher
    ..3.1.5) and (ii) an NAD cycling reaction using 12?-hydroxysteroid dehydrogenase (12?-HSD, EC 1.1.1.176) and diaphorase (DI, EC 1.6.99.3) to accumulate reduced WST-8...
  91. Regnier S, Kirkley A, Ruiz D, Kamau W, Wu Q, Kannan K, et al. Diet-dependence of metabolic perturbations mediated by the endocrine disruptor tolylfluanid. Endocr Connect. 2018;7:159-168 pubmed publisher
    ..Eight-week-old male C57BL/6 mice were fed a high-fat, high-sucrose diet (HFHSD) or a high-sucrose diet (HSD), with or without TF supplementation at 100??g/g, for 12 weeks...
  92. Hwang C, Chang P, Wang T. Contribution of remote substrate binding energy to the enzymatic rate acceleration for 3?-hydroxysteroid dehydrogenase/carbonyl reductase. Chem Biol Interact. 2017;276:133-140 pubmed publisher
    3?-Hydroxysteroid dehydrogenase/carbonyl reductase (3?-HSD/CR) catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH with the rate limiting step being the release of NADH...