cholecystokinin

Summary

Gene Symbol: cholecystokinin
Description: cholecystokinin
Alias: cholecystokinin, cholecystokinin triacontatriapeptide, prepro-cholecystokinin
Species: human
Products:     cholecystokinin

Top Publications

  1. Sturm K, MacIntosh C, Parker B, Wishart J, Horowitz M, Chapman I. Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women. J Clin Endocrinol Metab. 2003;88:3747-55 pubmed
    ..To investigate possible contributions of enhanced satiating effects of cholecystokinin (CCK) and reduced stimulation of food intake by ghrelin, eight undernourished older women [age, 80.4 +/- 2...
  2. Cremonini F, Camilleri M, McKinzie S, Carlson P, Camilleri C, Burton D, et al. Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. Am J Gastroenterol. 2005;100:652-63 pubmed
    b>Cholecystokinin (CCK) is involved in gastrointestinal motor response to meals. The potential role of CCK receptor antagonists in functional gastrointestinal disorders is unclear...
  3. Wu W, Ouyang B, Lu Z, Liu H, Tan Y, Cui P. CCK1 receptor is involved in the regulation of protein lysine acetylation in GBC-SD cells and gallbladder carcinoma. Ir J Med Sci. 2017;186:883-888 pubmed publisher
    CCK1 (cholecystokinin receptor 1) and protein lysine acetylation were associated with several cancers, respectively. However, whether they are involved in the alternation of gallbladder carcinoma is unknown...
  4. Zhou Y, Ru Y, Shi H, Wang Y, Wu B, Upur H, et al. Cholecystokinin receptors regulate sperm protein tyrosine phosphorylation via uptake of HCO3-. Reproduction. 2015;150:257-68 pubmed publisher
    b>Cholecystokinin (CCK), a peptide hormone and a neurotransmitter, was detected in mature sperm two decades ago. However, the exact role of CCK and the types of CCK receptors (now termed CCK1 and CCK2) in sperm have not been identified...
  5. Brzozowski T, Ptak Belowska A, Kwiecien S, Krzysiek Maczka G, Strzalka M, Drozdowicz D, et al. Novel concept in the mechanism of injury and protection of gastric mucosa: role of renin-angiotensin system and active metabolites of angiotensin. Curr Med Chem. 2012;19:55-62 pubmed
    ..oxide (NO) and calcitonin gene related peptide (CGRP) as well as appetite gut hormones including gastrin and cholecystokinin (CCK), leptin and recently ghrelin...
  6. Lipiński P, Garnuszek P, Maurin M, Stoll R, Metzler Nolte N, Wodyński A, et al. Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor. EJNMMI Res. 2018;8:33 pubmed publisher
    The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g...
  7. Rong Z, Chen H, Wang X, WANG Z, Xian G, Ma B, et al. Effects of sphincter of Oddi motility on the formation of cholesterol gallstones. World J Gastroenterol. 2016;22:5540-7 pubmed publisher
    ..b>Cholecystokinin-A receptor (CCKAR) expression levels in SO smooth muscle were detected by quantitative real-time PCR (qRT-PCR)..
  8. Duraisamy A, Bayen S, Saini S, Sharma A, Vats P, Singh S. Changes in ghrelin, CCK, GLP-1, and peroxisome proliferator-activated receptors in a hypoxia-induced anorexia rat model. Endokrynol Pol. 2015;66:334-41 pubmed publisher
    ..Ghrelin, cholecystokinin (CCK), and glucagon like peptide-1 (GLP-1), are gut hormones involved in the regulation of food intake and ..
  9. Mao J, Wu P, Huang J, Wu J, Yang G. Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma. World J Gastroenterol. 2014;20:12542-50 pubmed publisher
    ..mRNA expression of pentagastrin receptor/cholecystokinin-B receptor (CCK-BR), ERK1/2 and K-ras were detected by reverse transcriptase polymerase chain reaction...

More Information

Publications163 found, 100 shown here

  1. Wu W, Sheng K, Xu X, Zhang H, Zhou G. Potential roles for glucagon-like peptide-17-36 amide and cholecystokinin in anorectic response to the trichothecene mycotoxin T-2 toxin. Ecotoxicol Environ Saf. 2018;153:181-187 pubmed publisher
    ..to elucidate the roles of two gut satiety hormones, glucagon-like peptide-17-36 amide (GLP-1) and cholecystokinin (CCK) in T-2 toxin-evoked anorectic response using a mouse anorexia bioassay...
  2. Dong C, Liu Z, Wang F. Peptide-based radiopharmaceuticals for targeted tumor therapy. Curr Med Chem. 2014;21:139-52 pubmed
    ..tumors, such as integrin ?v?3, gastrin-releasing peptide receptor (GRPR), melanocortin-1 receptor (MC1-R), cholecystokinin (CCK) receptor, and glucagon-like peptide-1 receptor (GLP-1R)...
  3. Meng L, Wang J, Xu S, Zu L, Yan Z, Zhang J, et al. Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling. BMC Cancer. 2018;18:824 pubmed publisher
    ..Cellular and molecular experiments indicated that reduction of gastrin is associated with inactivation of cholecystokinin B receptor (CCKBR)/ERK/P65 signaling in BC cells which is corresponding to molecular type of estrogen ..
  4. Yamazaki T, Morimoto Kobayashi Y, Koizumi K, Takahashi C, Nakajima S, Kitao S, et al. Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue. J Nutr Biochem. 2019;64:80-87 pubmed publisher
    ..cells increases Ca2+ levels and induces the secretion of the gastrointestinal hormone, cholecystokinin (CCK), in a dose-dependent manner...
  5. Webb D, Rudholm Feldreich T, Gillberg L, Halim M, Theodorsson E, Sanger G, et al. The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:41-9 pubmed publisher
    ..from the proton pump inhibitor (PPI) esomeprazole in mode of action by antagonizing the type 2 receptor of cholecystokinin/gastrin (CCK-2R)...
  6. Smith J, Wang S, Nadella S, Jablonski S, Weiner L. Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice. Cancer Immunol Immunother. 2018;67:195-207 pubmed publisher
    ..b>Cholecystokinin (CCK) has been shown to stimulate growth of pancreatic cancer...
  7. Hornigold D, Roth E, Howard V, Will S, Oldham S, Coghlan M, et al. A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Appetite. 2018;127:334-340 pubmed publisher
    ..Co-administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist with a cholecystokinin receptor-1 (CCKR1) agonist exert synergistic effects on weight loss in obese rodents...
  8. Desai A, Dong M, Harikumar K, Miller L. Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function. Am J Physiol Gastrointest Liver Physiol. 2015;309:G377-86 pubmed publisher
    Dysfunction of the type 1 cholecystokinin (CCK) receptor (CCK1R) as a result of increased gallbladder muscularis membrane cholesterol has been implicated in the pathogenesis of cholesterol gallstones...
  9. Yang Y, Li Q, He Q, Han J, Su L, Wan Y. Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide. Exp Mol Med. 2018;50:64 pubmed publisher
    Activation of the cholecystokinin type B receptor (CCKBR) by cholecystokinin octapeptide (CCK-8) inhibits opioid analgesia...
  10. Svane M, Bojsen Møller K, Martinussen C, Dirksen C, Madsen J, Reitelseder S, et al. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2019;156:1627-1641.e1 pubmed publisher
    ..and amino acids were accompanied by higher secretion of insulin, glucagon-like peptide 1, peptide YY, and cholecystokinin after RYGB, whereas levels of ghrelin were lower after SG, compared with RYGB and controls...
  11. Ortinau L, Linden M, Dirkes R, Rector R, Hinton P. Exercise initiated after the onset of insulin resistance improves trabecular microarchitecture and cortical bone biomechanics of the tibia in hyperphagic Otsuka Long Evans Tokushima Fatty rats. Bone. 2017;103:188-199 pubmed publisher
    ..The OLETF rat is hyperphagic due to a loss-of-function mutation in cholecystokinin-1 receptor (CCK-1 receptor), which leads to progressive obesity, insulin resistance and T2D after the ..
  12. Nishimura S, Bilguvar K, Ishigame K, Sestan N, Gunel M, Louvi A. Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. PLoS ONE. 2015;10:e0124295 pubmed publisher
    b>Cholecystokinin (CCK), a peptide hormone and one of the most abundant neuropeptides in vertebrate brain, mediates its actions via two G-protein coupled receptors, CCKAR and CCKBR, respectively active in peripheral organs and the central ..
  13. Liang T, Dolai S, Xie L, Winter E, Orabi A, Karimian N, et al. Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology. J Biol Chem. 2017;292:5957-5969 pubmed publisher
    ..was assessed for physiologic and pathologic responses to the cholinergic agonist carbachol (Cch) and cholecystokinin (CCK-8), including 1) amylase secretion, 2) exocytosis, 3) intracellular Ca2+ responses, 4) ..
  14. Jacobsen S, Olesen S, Dirksen C, Jørgensen N, Bojsen Møller K, Kielgast U, et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes Surg. 2012;22:1084-96 pubmed publisher
    ..glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2 (GLP-2), peptide YY(3-36) (PYY), cholecystokinin (CCK), total and active ghrelin, gastrin, somatostatin, pancreatic polypeptide (PP), amylin, leptin, free ..
  15. Rai R, Kim J, Tewari M, Shukla H. Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: An immunohistochemical study. J Cancer Res Ther. 2016;12:411-6 pubmed publisher
    b>Cholecystokinin (CCK) and gastrin (Gs) are a well known trophic factor for the gastrointestinal tract and their trophic effects are shown mainly toward pancreas and stomach, respectively...
  16. Sonne D, Hare K, Martens P, Rehfeld J, Holst J, Vilsbøll T, et al. Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients. Am J Physiol Gastrointest Liver Physiol. 2013;304:G413-9 pubmed publisher
    ..glucagon, GLP-1, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2 (GLP-2), cholecystokinin (CCK), and gastrin were measured...
  17. Jin G, Ramanathan V, Quante M, Baik G, Yang X, Wang S, et al. Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. J Clin Invest. 2009;119:2691-701 pubmed publisher
    ..b>Cholecystokinin-2 receptor (CCK2R) is the primary receptor for cholecystokinin (CCK) and amidated gastrin...
  18. Wölnerhanssen B, Cajacob L, Keller N, Doody A, Rehfeld J, Drewe J, et al. Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab. 2016;310:E1053-61 pubmed publisher
    ..Glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) are released from the gut in response to food intake, promote satiation, reduce gastric emptying (GE), ..
  19. Sellam F, Harir N, Khaled M, Mrabent N, Belkralladi H, Tou A, et al. Immunohistochemical examination of cholecystokinin and gastrin receptors (CCK-2/gastrin-R) expression in normal and exocrine cancerous human pancreatic tissues. Pancreatology. 2015;15:661-6 pubmed publisher
  20. Kaufmann A, Rössler O, Thiel G. Expression of the transcription factor Egr-1 in pancreatic acinar cells following stimulation of cholecystokinin or Gαq-coupled designer receptors. Cell Physiol Biochem. 2014;33:1411-25 pubmed publisher
    BACKGOUND/AIMS: The injection of cerulein, an analogue of the pancreatic secretagogue cholecystokinin (CCK), induces acute pancreatitis in mice that is accompanied by the synthesis of the transcription factor Egr-1...
  21. Ansquer C, Kraeber Bodéré F, Chatal J. Current status and perspectives in peptide receptor radiation therapy. Curr Pharm Des. 2009;15:2453-62 pubmed
    ..Other peptides such as minigastrin, glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), bombesin (BN)/gastrin-releasing peptide (GRP), substance P, neurotensin (NT), neuropeptide Y (NPY) and ..
  22. Staljanssens D, Rico C, Park M, Van Camp J, Yu N, Huber T, et al. Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides. Peptides. 2015;68:219-27 pubmed publisher
    The cholecystokinin receptor type 1 (CCK1R) is a G protein-coupled receptor (GPCR) that is involved in several biological processes including the regulation of the secretion of digestive enzymes...
  23. Schroeter J, Fenn C, Small B. Elucidating the roles of gut neuropeptides on channel catfish feed intake, glycemia, and hypothalamic NPY and POMC expression. Comp Biochem Physiol A Mol Integr Physiol. 2015;188:168-74 pubmed publisher
    ..objective of this project was to elucidate the effects of ghrelin (GHRL), gastrin-releasing peptide (GRP), cholecystokinin (CCK), glucagon-like peptide (GLP), pancreatic polypeptide (PP), and peptide YY (PYY) on appetite, glycemia, ..
  24. Wen D, An M, Gou H, Liu X, Liu L, Ma C, et al. Cholecystokinin-8 inhibits methamphetamine-induced neurotoxicity via an anti-oxidative stress pathway. Neurotoxicology. 2016;57:31-38 pubmed publisher
    ..We found that pretreatment of cholecystokinin-8 (CCK-8) inhibited METH-induced brain cellular dopaminergic (DA) damage in the striatum and substantia nigra,..
  25. Olli K, Salli K, Alhoniemi E, Saarinen M, Ibarra A, Vasankari T, et al. Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants. Nutr J. 2015;14:2 pubmed publisher
    ..Postprandial plasma concentrations of satiety-related peptides, namely ghrelin, cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY), as well as SCFAs and lactic acid were assessed...
  26. Konno K, Takahashi Iwanaga H, Uchigashima M, Miyasaka K, Funakoshi A, Watanabe M, et al. Cellular and subcellular localization of cholecystokinin (CCK)-1 receptors in the pancreas, gallbladder, and stomach of mice. Histochem Cell Biol. 2015;143:301-12 pubmed publisher
    Information concerning the cellular localization of cholecystokinin (CCK)-1 receptors has been discrepant and remained scanty at ultrastructural levels...
  27. Saydam B, Yildiz B. Gut-Brain Axis and Metabolism in Polycystic Ovary Syndrome. Curr Pharm Des. 2016;22:5572-5587 pubmed
    ..peptides include glucagon like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY) and cholecystokinin (CCK)...
  28. Woods S, Leonard M, Hayden J, Brophy M, Bernert K, Lavoie B, et al. Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous "black" pigment gallstone formation in germfree Swiss Webster mice. Am J Physiol Gastrointest Liver Physiol. 2015;308:G335-49 pubmed publisher
    ..Aged GF and SPF SW mice had deficits in gallbladder smooth muscle activity. In response to cholecystokinin (CCK), gallbladders of fasted GF SW mice showed impaired emptying (females: 29%; males: 1% emptying), whereas ..
  29. van der Stelt I, Hoevenaars F, Siroká J, de Ronde L, Friedecky D, Keijer J, et al. Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality. Front Physiol. 2017;8:179 pubmed publisher
    ..Decreased expression of tryptophan hydroxylase 2 (Tph2) and cholecystokinin (Cck) might represent altered neuroendocrine signaling...
  30. Bai B, Chen X, Zhang R, Wang X, Jiang Y, Li D, et al. Dual-agonist occupancy of orexin receptor 1 and cholecystokinin A receptor heterodimers decreases G-protein-dependent signaling and migration in the human colon cancer cell line HT-29. Biochim Biophys Acta Mol Cell Res. 2017;1864:1153-1164 pubmed publisher
    The orexin (OX1R) and cholecystokinin A (CCK1R) receptors play opposing roles in the migration of the human colon cancer cell line HT-29, and may be involved in the pathogenesis and pathophysiology of cancer cell invasion and metastasis...
  31. Pitts P, Volkoff H. Characterization of appetite-regulating factors in platyfish, Xiphophorus maculatus (Cyprinodontiformes Poeciliidae). Comp Biochem Physiol A Mol Integr Physiol. 2017;208:80-88 pubmed publisher
    ..These signals include anorexigenic (e.g. cholecystokinin (CCK) and cocaine- and amphetamine-regulated transcript (CART)) as well as orexigenic (e.g...
  32. Bai M, Bornhop D. Recent advances in receptor-targeted fluorescent probes for in vivo cancer imaging. Curr Med Chem. 2012;19:4742-58 pubmed
    ..reported to target cancer-specific receptors, such as somatostatin receptors (SSTRs), integrin receptors, cholecystokinin-2 (CCK(2)) receptor, gastrin-releasing peptide (GRP) receptor, endothelin A (ET(A)) receptor, translocator ..
  33. Shen L, Wang D, Lo C, Arnold M, Tso P, Woods S, et al. Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats. Physiol Behav. 2015;152:62-7 pubmed publisher
    ..ip) administered Rb1 exerts its anorectic action by enhancing sensitivity to satiation signals, such as cholecystokinin (CCK), and/or that it acts through vagal afferent nerves that relay the satiating signaling to the hindbrain...
  34. Moguel Hernández I, Pena R, Andree K, Tovar Ramirez D, Bonacic K, Dumas S, et al. Ontogeny changes and weaning effects in gene expression patterns of digestive enzymes and regulatory digestive factors in spotted rose snapper (Lutjanus guttatus) larvae. Fish Physiol Biochem. 2016;42:1319-34 pubmed publisher
    ..phospholipase A and pepsinogen) and their relation with orexigenic (neuropeptide Y, NPY) and anorexigenic (cholecystokinin, CCK) factors during the larval development and to evaluate the effect of weaning in their expression...
  35. Desai A, Henke B, Miller L. Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity. Bioorg Med Chem Lett. 2015;25:1849-55 pubmed publisher
    b>Cholecystokinin (CCK) acts at the type 1 cholecystokinin receptor (CCK1R) to elicit satiety and is a well-established drug target for obesity...
  36. Maina T, Konijnenberg M, KolencPeitl P, Garnuszek P, Nock B, Kaloudi A, et al. Preclinical pharmacokinetics, biodistribution, radiation dosimetry and toxicity studies required for regulatory approval of a phase I clinical trial with (111)In-CP04 in medullary thyroid carcinoma patients. Eur J Pharm Sci. 2016;91:236-42 pubmed publisher
    From a series of radiolabelled cholecystokinin (CCK) and gastrin analogues, (111)In-CP04 ((111)In-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) was selected for further translation as a diagnostic radiopharmaceutical towards a first-in-..
  37. Gales C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, et al. Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies. Mol Pharmacol. 2003;63:973-82 pubmed
    The cholecystokinin (CCK) receptors CCK1R and CCK2R exert important central and peripheral functions by binding the neuropeptide cholecystokinin...
  38. Chen N, Jiang X, Wang J, Wu T, Cheng B, Xia J. CXCL12-CXCR4/CXCR7 axis contributes to cell motilities of oral squamous cell carcinoma. Tumour Biol. 2016;37:567-75 pubmed publisher
    ..Exogenous CXCL12 could promote cell migration and invasion. In conclusion, our results indicated that CXCL12 which combined its receptor CXCR4 and CXCR7 together could promote cell motilities of OSCC. ..
  39. Huang W, Cui X, Chen Y, Shao M, Shao X, Shen Y, et al. High VRK1 expression contributes to cell proliferation and survival in hepatocellular carcinoma. Pathol Res Pract. 2016;212:171-8 pubmed publisher
    ..On the basis of these findings, we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of HCC. ..
  40. Luttikhold J, Van Norren K, Rijna H, Buijs N, Ankersmit M, Heijboer A, et al. Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial. Am J Clin Nutr. 2016;103:435-43 pubmed publisher
    ..05). The postprandial rise in plasma cholecystokinin, peptide YY (PYY), glucagon-like peptide 1 (GLP-1), and glucagon-like peptide 2 (GLP-2) concentrations was ..
  41. Zhu Y, Zhang F, Zhang S, Deng W, Fan H, Wang H, et al. Regulatory mechanism and functional analysis of S100A9 in acute promyelocytic leukemia cells. Front Med. 2017;11:87-96 pubmed publisher
    ..Collectively, our data indicated that PML/RAR? and PU.1 were necessary for the ATRA-induced expression of S100A9 in APL cells. Furthermore, S100A9 promoted apoptosis in APL cells and affected cell growth. ..
  42. Just S, Chenard B, Ceci A, Strassmaier T, Chong J, Blair N, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS ONE. 2018;13:e0191225 pubmed publisher
    ..It also inhibits TRPC1/5 and TRPC1/4 heteromultimers with similar potency and reduces responses evoked by cholecystokinin tetrapeptide (CCK-4) in the amygdala...
  43. Feng J, Chen X, Wang Y, Du Y, Sun Q, Zang W, et al. Myricetin inhibits proliferation and induces apoptosis and cell cycle arrest in gastric cancer cells. Mol Cell Biochem. 2015;408:163-70 pubmed publisher
    ..Myricetin bound to RSK2, leading to increased expression of Mad1, and contributed to inhibition of HGC-27 and SGC7901 cell proliferation. Our results suggest the therapeutic potential of myricetin in GC. ..
  44. Nobile V, Duclos E, Michelotti A, Bizzaro G, Negro M, Soisson F. Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion. Food Nutr Res. 2016;60:29857 pubmed publisher
    ..whiting (Micromesistius poutassou) muscle by enzymatic hydrolysis, on body composition and on stimulating cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) secretion...
  45. Yan X, Zhang X, Ao R, Guan L. Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells. J Cell Biochem. 2017;118:4792-4803 pubmed publisher
    ..J. Cell. Biochem. 118: 4792-4803, 2017. © 2017 Wiley Periodicals, Inc. ..
  46. Son E, Kim Y, Park C, Park K, Jeong S, Park J, et al. Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. BMC Complement Altern Med. 2017;17:486 pubmed publisher
    ..CLSE inhibited migration, invasion, and adhesion of colon cancer cells and tube formation by HUVECs via repression of the ERK1/2 and AKT pathways under hypoxic conditions. Therefore, CLSE may be used to treat patients with colon cancer. ..
  47. Kakimoto T, Kanemoto H, Fukushima K, Ohno K, Tsujimoto H. Effect of a high-fat-high-cholesterol diet on gallbladder bile acid composition and gallbladder motility in dogs. Am J Vet Res. 2017;78:1406-1413 pubmed publisher
    ..Before and at the end of each feeding period, the concentrations of each of the gallbladder bile acids, cholecystokinin (CCK)-induced gallbladder motility, and bile acid metabolism-related hepatic gene expression were examined in ..
  48. Wang Z, Hu M, Dai M, Xiong J, Zhang S, Wu H, et al. Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway. Mol Cancer. 2018;17:3 pubmed publisher
    ..Taken together, our findings present a road map for targeting the newly identified lncRNA AFAP1-AS1 to suppress TSCC progression, and these results elucidate a novel potential therapeutic strategy for TSCC. ..
  49. Ruland T, Domschke K, Schütte V, Zavorotnyy M, Kugel H, Notzon S, et al. Neuropeptide S receptor gene variation modulates anterior cingulate cortex Glx levels during CCK-4 induced panic. Eur Neuropsychopharmacol. 2015;25:1677-82 pubmed publisher
    ..glutamate+glutamine (Glx) levels in the bilateral anterior cingulate cortex (ACC) during a pharmacological cholecystokinin tetrapeptide (CCK-4) panic challenge were assessed depending on the functional neuropeptide S receptor gene (..
  50. Wang R, Li R, Wen Q, Peng K, Tan X, Chen Z. [Expression of LXR-β in human gastric cancer tissue and the effect of GW3965 on the proliferation of gastric cancer cell line SGC-7901]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016;41:127-33 pubmed publisher
  51. Xu F, Xu C, Gu J, Liu X, Liu R, Huang E, et al. Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating β-catenin signaling pathway. Oncotarget. 2016;7:43401-43411 pubmed publisher
    ..EIF3B might serve as a novel marker for predicting prognosis of ESCC patients and as a potential therapeutic target, individually or together with other subunits of EIF3 complex. ..
  52. Hu D, Jiang Z. [Phospholipase C ?1 (PLCD1) inhibits the proliferation, invasion and migration of CAPAN-1 and BXPC-3 pancreatic cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:739-45 pubmed
    ..Conclusion PLCD1 transfection can induce the apoptosis of CAPAN-1 and BXPC-3 cells, arrest the cell cycle in G0 /G1 phase. Meanwhile, it inhibits the abilities of cell proliferation, invasion and migration of CAPAN-1 and BXPC-3 cells. ..
  53. Wang X, Qi N, Ma S, Yan Z, Wu Q, Wang L, et al. [Effect of BRD4 Inhibitor GSK525762A on Proliferation and Apoptosis of SUP-B15 Cells In Vitro and Its Possible Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1654-1658 pubmed publisher
    ..The GSK525762A can remarkably inhibit proliferation and induce apoptosis of SUP-B15 cells. The down-regulation of apoptosis-related genes C-MYC,CDK6 and BCL-2 may be involved in the process of apoptosis. ..
  54. Geng T, Zhao X, Ma M, Zhu G, Yin L. Resveratrol-Loaded Albumin Nanoparticles with Prolonged Blood Circulation and Improved Biocompatibility for Highly Effective Targeted Pancreatic Tumor Therapy. Nanoscale Res Lett. 2017;12:437 pubmed publisher
    ..These results demonstrate that HRP-RGD NPs with prolonged blood circulation and improved biocompatibility have high anti-cancer effects with promising future applications in cancer therapy. ..
  55. Dong X, Wang C, Zhang J, Wang S, Li H, Kang Y, et al. Cholecystokinin Expression in the Development of Postinfarction Heart Failure. Cell Physiol Biochem. 2017;43:2479-2488 pubmed publisher
    b>Cholecystokinin (CCK) is expressed in cardiomyocytes and may also play an important role in cardiovascular regulation...
  56. Deng W, Li Y, Jia Y, Tang L, He Q, Liu D. [Over-expression of thioredoxin-interacting protein promotes apoptosis of MIN6 cells via activating p38MAPK pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1323-1327 pubmed
    ..Conclusion TXNIP over-expression might promote the apoptosis of MIN6 cells via activating the p38 MAPK pathway. ..
  57. Yeomans M, Re R, Wickham M, Lundholm H, Chambers L. Beyond expectations: the physiological basis of sensory enhancement of satiety. Int J Obes (Lond). 2016;40:1693-1698 pubmed publisher
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    ..The results of the present study identified a crucial tumor promotive role of BCAR4 in the progression of osteosarcoma, and suggested that BCAR4 may be a potential therapeutic agent for the treatment of osteosarcoma. ..
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    ..Our results provide the new evidence supporting the tumor-suppressive role of miR-511 in GC by suppressing TRIM24, suggesting that this novel miR-511/TRIM24 axis is critical in the control of gastric cancer tumorigenesis. ..
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    ..increased P-glycoprotein (P-gp) mRNA level and transport activity via release of the gastrointestinal hormone cholecystokinin-8 (CCK-8) at 9 h...
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    ..We demonstrate Neto1/2 expression in somatostatin (SOM)-, cholecystokinin/cannabinoid receptor 1 (CCK/CB1)-, and parvalbumin (PV)-containing interneurons...
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    ..71±1.64)%, and the apoptosis rate of U266 cells was significantly elevated in NUPR1 knockdown group. Conclusion Down-regulating the expression of NUPR1 in U266 cells can inhibit cell proliferation and promote its apoptosis. ..
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    ..LncRNA-CRNDE promotes the proliferation and cell cycle of U937 cells, and inhibits cell apoptosis, which is expected to become a molecular marker for predicting and treating AML. ..
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    ..These findings demonstrated that miR-138 inhibited cervical cancer cells proliferation via c-Met, providing a novel target for the molecular treatment of cervical cancer. ..
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    ..b>Conclusions: These findings suggest that aberrant expression of lncRNA AFAP1-AS, a ceRNA of miR-181a, may involve in the onset and progression of HSCR by augmenting the miR-181a target gene, RAP1B. ..
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    ..These data uncovered an essential function of miR-377/XIAP signaling axis in regulating cisplatin resistance of OS. MiR-377 may have potential therapeutic values in tackling OS chemoresistance. ..
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    ..7 cells. Effususin B exhibited moderate to strong cytotoxic activities against the tested cancer cell lines and moderate anti-inflammatory activity. ..
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    ..These results indicated that SOX18 may function as an oncogene, and may provide a novel and promising therapeutic strategy for osteosarcoma. ..
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    ..The protein level of p21 was not significantly regulated by miR-15a overexpression or suppression. These results indicated that miR-15a played a role for inhibition of proliferation and induction of apoptosis in CNE1 cells. ..
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    ..Bupivacaine induced neurotoxicity by activating apoptosis via the mitochondrial pathway, and this was inhibited by GM-1 pretreatment. ..
  78. Volkoff H, Estevan Sabioni R, Coutinho L, Cyrino J. Appetite regulating factors in pacu (Piaractus mesopotamicus): Tissue distribution and effects of food quantity and quality on gene expression. Comp Biochem Physiol A Mol Integr Physiol. 2017;203:241-254 pubmed publisher
    ..In this study, transcripts for orexin, cocaine and amphetamine regulated transcript (CART), cholecystokinin (CCK) and leptin were isolated in pacu...
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    b>Background: Cholecystokinin (CCK) is an important satiety factor, acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clinical trials for obesity...
  81. Guo X, Yan F, Shan X, Li J, Yang Y, Zhang J, et al. SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through ?-catenin/PPAR-? signaling. Life Sci. 2017;186:111-117 pubmed publisher
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    ..Cellular imaging results indicated P1 could be utilized as cellular imaging of HeLa cells, where red fluorescence was observed in the partial cytoplasm. Moreover, CCK-8 assay showed P1 had a low cytotoxicity. ..
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    ..IL-17 also increased the migration of LLC cells in vitro. In conclusion, IL-17 exhibited the ability to promote tumor growth by increasing angiogenesis, metastasis and increasing CCR2+ macrophage infiltration into tumors. ..
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    ..CLDN1 activates autophagy through up-regulation of ULK1 phosphorylation and promotes drug resistance of NSCLC cells to CDDP. ..
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    ..In conclusion, miR-424 could suppress the bFGF/FGFR1 pathway, thereby inhibit ERK1/2 phosphorylation, and thus inhibit cell proliferation, migration and tube formation capabilities and the development of infantile skin hemangioma. ..
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    ..05).? Conclusion: Atmospheric PM2.5 can cause inflammatory response in human bronchial epithelial cells. They can reduce cell viability, which may be related to the PM2.5 trigger and aggravation of bronchopulmonary inflammatory diseases...
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