Gene Symbol: CHN2
Description: chimerin 2
Alias: ARHGAP3, BCH, CHN2-3, RHOGAP3, beta-chimaerin, beta-chimerin, beta3-chimaerin, chimerin (chimaerin) 2, chimerin, beta-2, chimerin, testis-specific, rho-GTPase-activating protein 3
Species: human
Products:     CHN2

Top Publications

  1. Hashimoto R, Yoshida M, Kunugi H, Ozaki N, Yamanouchi Y, Iwata N, et al. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res. 2005;73:383-5 pubmed
  2. Nishiu M, Yanagawa R, Nakatsuka S, Yao M, Tsunoda T, Nakamura Y, et al. Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression. Jpn J Cancer Res. 2002;93:894-901 pubmed
    ..Increased expression of MPHOSPH1, RUVBL1, CHN2, PSA and CDC10 genes, and reduced expression of COL1A2, COL4A1, FBLN5, CLECSF6, MIC2, CAV1 and S100A10 genes in the ..
  3. Siliceo M, García Bernal D, Carrasco S, Diaz Flores E, Coluccio Leskow F, Leskow F, et al. Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells. J Cell Sci. 2006;119:141-52 pubmed
    ..These studies demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells and suggest a functional role for this protein in Rac-mediated cytoskeletal remodeling. ..
  4. Caloca M, Delgado P, Alarcon B, Bustelo X. Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling. Cell Signal. 2008;20:758-70 pubmed publisher
    ..Taken together, these results identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells. ..
  5. Siliceo M, Merida I. T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells. J Biol Chem. 2009;284:11354-63 pubmed publisher
    ..This study establishes the existence of TCR-dependent regulation of beta2-chimaerin and identifies a novel mechanism for its inactivation. ..
  6. Maeda S, Araki S, Babazono T, Toyoda M, Umezono T, Kawai K, et al. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes. 2010;59:2075-9 pubmed publisher
    ..We genotyped 11 singlenucleotide polymorphisms (SNPs) in four distinct loci (rs39059 and rs39075 in the CPVL/CHN2, rs1888747 and rs10868025 in FRMD3, rs739401 and rs451041 in CARS, and rs1041466, rs1411766, rs6492208, rs7989848, ..
  7. Yamane S, Nomura R, Yanagihara M, Nakamura H, Fujino H, Matsumoto K, et al. L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. Eur J Pharmacol. 2015;764:471-9 pubmed publisher
    ..2.1]heptane-2-carboxylate (BCH), an inhibitor of systems L and B°(,+)...
  8. Wells S, Shermont H, Hockman G, Hamilton S, Abecassis L, Blanchette S, et al. Standardized Tracheostomy Education Across the Enterprise. J Pediatr Nurs. 2018;43:120-126 pubmed publisher
    ..Boston Children's Hospital (BCH) is a free-standing urban tertiary pediatric hospital with 15 inpatient units...
  9. Costa L, Guimarães D, de Souza R, Bomfin R. Cooperative Spectrum Sensing with Coded and Uncoded Decision Fusion under Correlated Shadowed Fading Report Channels. Sensors (Basel). 2018;19: pubmed publisher
    ..Binary bch and Repetition codes are used to protect these decisions...

More Information

Publications125 found, 100 shown here

  1. Khan M, Khan S, Ding X, Khan A, Alam M. The effects of biochar and rice husk on adsorption and desorption of cadmium on to soils with different water conditions (upland and saturated). Chemosphere. 2018;193:1120-1126 pubmed publisher
    Hard wood derived biochar (BCH) and rice husk (RCH) were applied to soils having upland and saturated conditions to investigate their effects on adsorption and desorption of Cd by conducting incubation and batch experiments...
  2. Kaji M, Kabir Salmani M, Anzai N, Jin C, Akimoto Y, Horita A, et al. Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. Int J Gynecol Cancer. 2010;20:329-36 pubmed publisher
    ..Furthermore, we examined the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), the classic inhibitor of system L on the survival, the migration, and the uptake of l-leucine by human epithelial ..
  3. Wibowo M, Wang Q, Holst J, White J, Hofmann A, Davis R. Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors. Phytochemistry. 2018;148:71-77 pubmed publisher
    ..were more potent than the L-type amino acid transporter (LAT) family inhibitor 2-aminobicyclo[2,2,1]-heptane-2-carboxylic acid (BCH). Bilocularins D-F are the first examples of dihydro-β-agarofurans bearing a hydroxyacetate group.
  4. Hasan N, Longacre M, Stoker S, Kendrick M, Druckenbrod N, Laychock S, et al. Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. Arch Biochem Biophys. 2012;518:23-30 pubmed publisher
    ..enzyme activity (SK11 and SK14) exhibited lowered glucose- and 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) plus glutamine-stimulated insulin release and low insulin content associated with decreases in the mRNA of the ..
  5. Smith H, Smith T. Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase. Biochemistry. 2016;55:6568-6576 pubmed
    ..75-E10 is ?1000-fold more efficacious than the synthetic activator, BCH, and is at least as effective as ADP...
  6. Yorlets R, Busa K, Eberlin K, Raisolsadat M, Bae D, Waters P, et al. Fingertip Injuries in Children: Epidemiology, Financial Burden, and Implications for Prevention. Hand (N Y). 2017;12:342-347 pubmed publisher
    ..1807 patients with fingertip injuries who presented to the emergency department (ED) at Boston Children's Hospital (BCH) between 2005 and 2011. Billing records were analyzed for financial data...
  7. Pacheco N, Naal Ek M, Ayora Talavera T, Shirai K, Román Guerrero A, Fabela Morón M, et al. Effect of bio-chemical chitosan and gallic acid into rheology and physicochemical properties of ternary edible films. Int J Biol Macromol. 2018;: pubmed publisher
    The ternary edible films based on commercial or bio-chemical chitosan (CCh or BCh) and starch (S) with different concentration of gallic acid (GA) were produced by casting...
  8. Hu X, Deng K. Bladder cavernous hemangioma after pelvic radiotherapy in a female patient: A case report and literature review. Int J Surg Case Rep. 2018;53:479-482 pubmed publisher
    ..Here we reported a female patient diagnosed with bladder cavernous hemangioma (BCH) after recent pelvic radiotherapy for the cervical cancer and reviewed relevant literatures...
  9. He B, Zhang N, Zhao R. Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells. J Cell Physiol. 2016;231:233-42 pubmed publisher
    ..Similar cellular responses were observed in BeWo cells treated with BCH, a classical System L inhibitor which inactivates SLC7A5...
  10. Wibowo M, Wang Q, Holst J, White J, Hofmann A, Davis R. Celastrofurans A-G: Dihydro-β-agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells. J Nat Prod. 2017;80:1918-1925 pubmed publisher
    ..0 to 98.9 μM. Dihydro-β-agarofurans 1-9 showed better potency than the L-type amino acid transporter (LAT) family inhibitor, 2-aminobicyclo[2.2.1]-heptane-2-carboxylic acid (BCH).
  11. Hodgeman R, Kapur K, Paris A, Marti C, Can A, Kimia A, et al. Effectiveness of once-daily high-dose ACTH for infantile spasms. Epilepsy Behav. 2016;59:4-8 pubmed publisher
    ..our center's practice, we retrospectively reviewed 57 cases over the past four years at Boston Children's Hospital (BCH)...
  12. Gao C, Zhang R, Liu S, Zhao X, Cui L, Yue Z, et al. Low CREBBP expression is associated with adverse long-term outcomes in paediatric acute lymphoblastic leukaemia. Eur J Haematol. 2017;99:150-159 pubmed publisher
    ..We studied CREBBP mRNA expression in 349 patients treated with either the BCH-2003 or CCLG-2008 protocol...
  13. Bao Z, Sun Y, Rai K, Peng X, Wang S, Nian R, et al. The promising indicators of the thermal and mechanical properties of collagen from bass and tilapia: synergistic effects of hydroxyproline and cysteine. Biomater Sci. 2018;6:3042-3052 pubmed publisher
    ..35%). After incubation at different temperatures for 9 h, more degraded collagen bands appeared in the BC hydrogel (BCH) group than in the TC hydrogel (TCH) group, indicating that TCH exhibited better thermal stability than BCH...
  14. Yi P, Chew L, Zhang Z, Ren H, Wang F, Cong X, et al. KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation. Mol Biol Cell. 2015;26:29-42 pubmed publisher
    ..and far-Western study revealed that BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain...
  15. Karppinen K, Zoratti L, Sarala M, Carvalho E, Hirsimäki J, Mentula H, et al. Carotenoid metabolism during bilberry (Vaccinium myrtillus L.) fruit development under different light conditions is regulated by biosynthesis and degradation. BMC Plant Biol. 2016;16:95 pubmed publisher
    ..In this study, carotenoid biosynthetic genes, PSY, PDS, ZDS, CRTISO, LCYB, LCYE, BCH and CYP450-BCH, as well as a carotenoid cleavage dioxygenase CCD1 were identified from bilberry (V. myrtillus L...
  16. Hernandez Pigeon H, Garidou L, Galliano M, Delga H, Ariès M, Duplan H, et al. Effects of dextran sulfate, 4-t-butylcyclohexanol, pongamia oil and hesperidin methyl chalcone on inflammatory and vascular responses implicated in rosacea. Clin Cosmet Investig Dermatol. 2018;11:421-429 pubmed publisher
    ..We evaluated the activity of four compounds (dextran sulfate, 4-t-butylcyclohexanol [BCH; TRP-regulin®], pongamia oil, and hesperidin methyl chalcone [HMC]) on inflammatory and vascular ..
  17. Tade F, Wiles W, Lu G, Bilir B, Akin Akintayo O, Lee J, et al. Selective modification of fluciclovine (18F) transport in prostate carcinoma xenografts. Amino Acids. 2018;50:1301-1305 pubmed publisher
    ..Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43...
  18. Agardh E, Lundstig A, Perfilyev A, Volkov P, Freiburghaus T, Lindholm E, et al. Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. BMC Med. 2015;13:182 pubmed publisher
    ..DNA methylation of 349 CpG sites representing 233 unique genes including TNF, CHI3L1 (also known as YKL-40), CHN2, GIPR, GLRA1, GPX1, AHRR, and BCOR in cases with PDR compared with controls...
  19. Li Y, Liu X, Wu X, Dong F, Xu J, Pan X, et al. Effects of biochars on the fate of acetochlor in soil and on its uptake in maize seedling. Environ Pollut. 2018;241:710-719 pubmed publisher
    ..54??g1-nLn/kg (biochars made of crofton weed, BCH) and 2.27??g1-nLn/kg (biochars made of wood chips, BCW)...
  20. Zhen H, Nakamura K, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, et al. Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter. Biosci Biotechnol Biochem. 2015;79:2057-62 pubmed publisher
    ..amino acid profiles in mice with and without the treatment of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) or rapamycin as an inhibitor of system L or mammalian target of rapamycin complex 1, respectively...
  21. Ogihara K, Naya Y, Sato R, Onda K, Ochiai H. Analysis of L-type amino acid transporter in canine hepatocellular carcinoma. J Vet Med Sci. 2015;77:527-34 pubmed publisher
    ..628 ± 0.018 nmol/mg protein/min. The inhibitor of LAT 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduced 90% of the activity at 1 mM...
  22. Oelsner K, Guo Y, To S, Non A, Barkin S. Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. BMC Genomics. 2017;18:57 pubmed publisher
    ..Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway...
  23. Shave S, Blackburn E, Adie J, Houston D, Auer M, Webster S, et al. UFSRAT: Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11βHSD1. PLoS ONE. 2015;10:e0116570 pubmed publisher
    ..This demonstrates the valuable ability of the UFSRAT algorithm to perform scaffold hops. A web-based implementation of the algorithm is freely available at
  24. Silva T, Oliveira C, Faria E, Mauad E, Syrjänen K, Carvalho A. Development and validation of a nomogram to estimate the risk of prostate cancer in Brazil. Anticancer Res. 2015;35:2881-6 pubmed
    ..This was a cross-sectional observational study on a cohort of men screened for PCa at the Barretos Cancer Hospital (BCH) between January 2004 and December 2007...
  25. Tatsumi Y, Takano R, Islam M, Yokochi T, Itami M, Nakamura Y, et al. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell Death Dis. 2015;6:e1607 pubmed publisher
    BNIP2 and Cdc42GAP homology (BCH) motif-containing molecule at the carboxyl-terminal region 1 (BMCC1) gene is highly expressed in patients with favorable neuroblastoma (NB)...
  26. Ashraf N, Jain D, Vishwakarma R. Identification, cloning and characterization of an ultrapetala transcription factor CsULT1 from Crocus: a novel regulator of apocarotenoid biosynthesis. BMC Plant Biol. 2015;15:25 pubmed publisher
    ..expression of key pathway genes like phytoene synthase (PSY), phytoene desaturase (PDS), beta carotene hydroxylase (BCH) and carotenoid cleavage dioxygenases (CCDs) indicating its role in regulation of apocarotenoid biosynthesis...
  27. Khamwan K, Plyku D, O Reilly S, Goodkind A, Cao X, Fahey F, et al. Pharmacokinetic modeling of [(18)F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds. EJNMMI Res. 2016;6:28 pubmed publisher
  28. Hadjipieri M, Georgiadou E, MarIn A, Díaz Mula H, Goulas V, Fotopoulos V, et al. Metabolic and transcriptional elucidation of the carotenoid biosynthesis pathway in peel and flesh tissue of loquat fruit during on-tree development. BMC Plant Biol. 2017;17:102 pubmed publisher
    ..PSY1, ZDS, CYCB and BCH were up-regulated and CRTISO, LCYE, ECH and VDE were down-regulated in most of the developmental stages compared ..
  29. Krogman J, Bezpalko M, Foxman B, Thomas C. Multi-electron redox processes at a Zr(iv) center facilitated by an appended redox-active cobalt-containing metalloligand. Dalton Trans. 2016;45:11182-90 pubmed publisher
    ..diazo reagent ethyl diazoacetate affords a tetranuclear Zr(IV)/Co(0) complex, ((t)BuNC)Co((i)Pr2PNMes)3Zr(?2-?(1)-O-?(2)-N,N-OC(OEt)CHN2)Zr(MesNP(i)Pr2)3Co(CN(t)Bu) (), bridged through enolate and ?(2)-bound diazo functionalities.
  30. Surwase S, Deshpande K, Phugare S, Jadhav J. Biotransformation studies of textile dye Remazol Orange 3R. 3 Biotech. 2013;3:267-275 pubmed publisher
    ..of Remazol Orange 3R (RO3R) was studied using well-known bacterial isolate Pseudomonas aeruginosa strain BCH. The dye was decolorized up to 98 % within 15 min...
  31. Wu H, Shi N, An X, Liu C, Fu H, Cao L, et al. Candidate Genes for Yellow Leaf Color in Common Wheat (Triticum aestivum L.) and Major Related Metabolic Pathways according to Transcriptome Profiling. Int J Mol Sci. 2018;19: pubmed publisher
    ..e., ?-carotene hydroxylase (BCH) genes), photosynthesis, and carbon fixation in photosynthetic organisms...
  32. Liu X, Li W, Zhao X, Gao C, Zhao W, Jiang J, et al. [Clinical Characteristics and Treatment Efficacy of Children with SIL/TAL1 Positive T-Cell Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:681-6 pubmed publisher
    ..The treatment efficacy in children with SIL-TAL1 positive T-ALL was compared between BCH-2003 and CCLG-2008 protocol. Out of 101 cases, 22 cases (21.9%) of T-ALL carried SIL-TAL1 fusion gene...
  33. Spinato S, Rebaudi A, Bernardello F, Bertoldi C, Zaffe D. Piezosurgical treatment of crestal bone: quantitative comparison of post-extractive socket outcomes with those of traditional treatment. Clin Oral Implants Res. 2016;27:361-6 pubmed publisher
    ..Buccal (BCH) and palatal (PCH) cortex height, bucco-palatal ridge (BPR) width were monitored at tooth extraction and after the ..
  34. Geng J, Picker J, Zheng Z, Zhang X, Wang J, Hisama F, et al. Chromosome microarray testing for patients with congenital heart defects reveals novel disease causing loci and high diagnostic yield. BMC Genomics. 2014;15:1127 pubmed publisher
    ..assessed the detected CNVs in a total of 514 CHD cases (a 422-case clinical cohort from Boston Children's Hospital (BCH) and a 92-case research cohort from Shanghai Children's Medical Center (SCMC)) and conducted a genotype-phenotype ..
  35. Lingren T, Thaker V, Brady C, Namjou B, Kennebeck S, Bickel J, et al. Developing an Algorithm to Detect Early Childhood Obesity in Two Tertiary Pediatric Medical Centers. Appl Clin Inform. 2016;7:693-706 pubmed publisher
    ..were developed using structured and unstructured data from two EHR databases from Boston Children's Hospital (BCH) and Cincinnati Children's Hospital and Medical Center (CCHMC)...
  36. van Geldermalsen M, Quek L, Turner N, Freidman N, Pang A, Guan Y, et al. Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways. BMC Cancer. 2018;18:689 pubmed publisher
    ..These effects were not primarily leucine-mediated, as BenSer was more cytostatic than the LAT family inhibitor, BCH. Oocyte uptake assays with ectopically expressed amino acid transporters identified four additional targets of ..
  37. Ohshima Y, Kaira K, Yamaguchi A, Oriuchi N, Tominaga H, Nagamori S, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016;107:1499-1505 pubmed publisher
    ..A selective inhibitor of LAT, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), suppressed cellular uptake of l-14 C-leucine and cell proliferation in a dose-dependent manner...
  38. Xu S, Tang K, Meng L, Tang Y. Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci. 2013;33:632-635 pubmed publisher
    ..MTT) assay after blocking LAT3 expression with either shRNA targeted to LAT3 or a small molecular inhibitor BCH (2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid)...
  39. Dong Q, Zhang X, Yu Z, Yan J, Chen X. [Synthesis reduction of central neurotransmitter 5-hydroxytryptamine by branched chain amino acid and associated antagonists improves postoperative fatigue syndrome]. Zhonghua Wei Chang Wai Ke Za Zhi. 2014;17:985-9 pubmed
    ..C group and the M group were injected with normal saline, while other three groups were respectively injected with BCH, fluoxetine, BCAA(val:leucine:isoleucine=5:3:2), on preoperative 1 h, postoperative day 1, 2, 3, 4...
  40. Dolgodilina E, Imobersteg S, Laczko E, Welt T, Verrey F, Makrides V. Brain interstitial fluid glutamine homeostasis is controlled by blood-brain barrier SLC7A5/LAT1 amino acid transporter. J Cereb Blood Flow Metab. 2016;36:1929-1941 pubmed perfusion with α-(methylamino)-isobutyric acid (MeAIB) or 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) respectively, was tested...
  41. Chan T, Xie Z. The synthesis, structure and reactivity of an imine-stabilized carboranylphosphorus(i) compound. Chem Commun (Camb). 2016;52:7280-3 pubmed publisher
    ..Such a monovalent phosphorous(i) compound can undergo reactions with Cu(OAc)2, S, Se, (TMS)CHN2 and HCl to give various phosphorus(iii) species...
  42. Islam S, Ueda M, Nishida E, Wang M, Osawa M, Lee D, et al. Odor preference and olfactory memory are impaired in Olfaxin-deficient mice. Brain Res. 2018;1688:81-90 pubmed publisher
    Olfaxin, which is a BNIP2 and Cdc42GAP homology (BCH) domain-containing protein, is predominantly expressed in mitral and tufted (M/T) cells in the olfactory bulb (OB). Olfaxin and Caytaxin, which share 56...
  43. Al Ayubi S, Pelletier A, Sunthara G, Gujral N, Mittal V, Bourgeois F. A Mobile App Development Guideline for Hospital Settings: Maximizing the Use of and Minimizing the Security Risks of "Bring Your Own Devices" Policies. JMIR Mhealth Uhealth. 2016;4:e50 pubmed publisher
    ..development of an in-house mobile app called TaskList, pilot the TaskList app within Boston Children's Hospital (BCH), and refine the guideline based on the app pilot...
  44. Wang X, Tan D, Ma J, Liang H, Zhang Q, Tan Y, et al. Positive Regulation of Decidualization by l-Type Amino Acid Transporter 1 (lat1) in Pregnant Mice. Nutrients. 2016;8: pubmed
    ..RNA and by a competitive inhibitor of Leucine transport 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH). The effects of lat1 on decidualization in vivo were assessed by injecting BCH into the uterine horns...
  45. Wisutiamonkul A, Ampomah Dwamena C, Allan A, Ketsa S. Carotenoid accumulation in durian (Durio zibethinus) fruit is affected by ethylene via modulation of carotenoid pathway gene expression. Plant Physiol Biochem. 2017;115:308-319 pubmed publisher
    ..lycopene beta-cyclase (LCYB), chromoplast specific lycopene beta-cyclase (CYCB) and beta-carotene hydroxylase (BCH) genes was highly correlated with carotenoid content and pulp color...
  46. Grinsztejn E, Percy M, McClenaghan D, Quintana M, Cuthbert R, McMullin M. The prevalence of CALR mutations in a cohort of patients with myeloproliferative neoplasms. Int J Lab Hematol. 2016;38:102-6 pubmed publisher
    ..JAK2/MPL-non-mutated patients from the Belfast City Hospital (BCH) with either of the MPNs - ET or MF - and diagnosed between 1988 and 2014 were selected for CALR screen...
  47. Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, et al. Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography. J Pharmacol Sci. 2016;130:101-9 pubmed publisher
    ..The amino acid uptake inhibitor, 2-amino-2-norbornanecarboxylic acid (BCH), also inhibited the [(14)C]FAMT uptake, whereas OCTN2-mediated [(14)C]FAMT uptake was Na(+)-dependent...
  48. Bourezane Y. Analysis of trichoscopic signs observed in 24 patients presenting tinea capitis: Hypotheses based on physiopathology and proposed new classification. Ann Dermatol Venereol. 2017;144:490-496 pubmed publisher
    ..of the hair shaft have been described, with the main ones being: comma hair, corkscrew hair, bar code-like hair (BCH) and zigzag hair (ZZH). Herein we report on a retrospective study of 24 patients with tinea capitis (TC)...
  49. Sekine A, Kuroki Y, Urata T, Mori N, Fukuwatari T. Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain. Neurochem Res. 2016;41:2256-66 pubmed publisher
    ..was investigated in vitro and in vivo using an LATs inhibitor, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH)...
  50. Wang Y, Liu J, Wu H, Fang X, Chen H, Zhang C. Amino acids regulate mTOR pathway and milk protein synthesis in a mouse mammary epithelial cell line is partly mediated by T1R1/T1R3. Eur J Nutr. 2017;56:2467-2474 pubmed publisher
    ..Activation of the mTOR pathway was partially repressed by T1R1 siRNA or SLC7A5/SLC3A2 inhibitor (BCH, 10 mM), and the combination of these two treatments further repressed the activity of this pathway...
  51. Fornes F, Belda R. Acidification with nitric acid improves chemical characteristics and reduces phytotoxicity of alkaline chars. J Environ Manage. 2017;191:237-243 pubmed publisher
    ..We have studied three materials which combine these factors: two pyrolyzed biochars, one from forest waste (BCH-FW) and another from olive mill waste (BCH-OMW), and one hydrothermally carbonized hydrochar from forest waste (HYD-..
  52. Bøe T, Skogen J, Sivertsen B, Hysing M, Petrie K, Dearing E, et al. Economic volatility in childhood and subsequent adolescent mental health problems: a longitudinal population-based study of adolescents. BMJ Open. 2017;7:e017030 pubmed publisher
    ..Latent class analysis and the BCH approach in Mplus were used to examine associations between patterns of poverty exposure and mental health outcomes...
  53. Baldissera M, Souza C, Grando T, Da Silva A, Monteiro S. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microb Pathog. 2016;99:191-195 pubmed publisher
    ..decrease the activities of AChE, BChE and ADA in order to reduce the oxidative damage increasing the levels of ACh, BCh and adenosine. These alterations in the kidney may be contribute on pathophysiology of T. evansi infection.
  54. Resnick C, Dang R, Henderson L, Zander D, Daniels K, Nigrovic P, et al. Frequency and Morbidity of Temporomandibular Joint Involvement in Adult Patients With a History of Juvenile Idiopathic Arthritis. J Oral Maxillofac Surg. 2017;75:1191-1200 pubmed publisher included adults (>19 years of age) with JIA who were managed at Boston Children's Hospital (BCH) as children and at Brigham and Women's Hospital (BWH) as adults...
  55. Lee K, Kang Y. Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells). J Biomed Sci. 2017;24:28 pubmed publisher
    ..uptake in the cells was markedly inhibited by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), which is the inhibitor of the large neutral amino acid transporter 1 (LAT1), B0, B0,+ and ..
  56. Kane D, Friedman K, Fulton D, Geggel R, Saleeb S. Needles in Hay II: Detecting Cardiac Pathology by the Pediatric Chest Pain Standardized Clinical Assessment and Management Plan. Congenit Heart Dis. 2016;11:396-402 pubmed publisher
    ..embolus, pulmonary hypertension, pericarditis, or myocarditis were identified from the Boston Children's Hospital (BCH) cardiac database between July 1, 2010 and December 31, 2012...
  57. Manibalan K, Chen S, Mani V, Huang T, Huang S. A Sensitive Ratiometric Long-Wavelength Fluorescent Probe for Selective Determination of Cysteine/Homocysteine. J Fluoresc. 2016;26:1489-95 pubmed publisher
    ..Only cysteine/homocysteine able to react with BBCH to release fluorescence reporter (BCH, 1); while, glutathione and other amino acids unable to react with BBCH due to the absence of adjacent amino groups...
  58. Jiang T, Pan C, Low B. BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis. Oncogene. 2017;36:3178-3192 pubmed publisher
    ..Furthermore, we identify that BPGAP1 (a BCH domain-containing, Cdc42GAP-like Rho GTPase-activating protein) promotes MEK partner 1 (MP1)-induced ERK activation ..
  59. Kagawa S, Nishii R, Higashi T, Yamauchi H, Ogawa E, Okudaira H, et al. Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [3H]methionine uptake. Nucl Med Biol. 2017;49:8-15 pubmed publisher
    ..MeAIB was used to inhibit the A system and 2-amino-2-norbornane-carboxylic acid (BCH) was used to inhibit the L system...
  60. Bray B, Dziak J, Patrick M, Lanza S. Inverse Propensity Score Weighting with a Latent Class Exposure: Estimating the Causal Effect of Reported Reasons for Alcohol Use on Problem Alcohol Use 16 Years Later. Prev Sci. 2018;: pubmed publisher
    ..e., the BCH approach), in order to estimate the causal effects of reasons for alcohol use latent class membership during the ..
  61. Napolitano L, Scalise M, Galluccio M, Pochini L, Albanese L, Indiveri C. LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter. Int J Biochem Cell Biol. 2015;67:25-33 pubmed publisher
    ..LAT1 function was evaluated in intact cells as BCH sensitive [(3)H]His transport inhibited by hydrophobic amino acids...
  62. Eichenberger R, Ramakrishnan C, Russo G, Deplazes P, Hehl A. Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors. Sci Rep. 2017;7:3357 pubmed publisher
    ..canis genome sequence of a virulent Hungarian field isolate (strain BcH-CHIPZ) underpinned by extensive genome-wide RNA-seq analysis...
  63. Grignon D, Ro J, Ordonez N, Ayala A, Cleary K. Basal cell hyperplasia, adenoid basal cell tumor, and adenoid cystic carcinoma of the prostate gland: an immunohistochemical study. Hum Pathol. 1988;19:1425-33 pubmed
    Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland...
  64. Pankova O, Denisov E, Ponomaryova A, Gerashchenko T, Tuzikov S, Perelmuter V. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium. Tumour Biol. 2016;37:3599-607 pubmed publisher
    ..lung tissue from 104 patients with squamous NSCLC were used for the determination of basal cell hyperplasia (BCH) and squamous metaplasia (SM) and for the analysis of the expression of Ki-67, p53, Bcl-2, and CD138...
  65. Sugiyama K, Ebisawa M, Yamada M, Nagashima Y, Suzuki H, Maoka T, et al. Functional Lycopene Cyclase (CruA) in Cyanobacterium, Arthrospira platensis NIES-39, and its Role in Carotenoid Synthesis. Plant Cell Physiol. 2017;58:831-838 pubmed publisher
    ..coli, which contains ?-carotene. Among the ?-carotene hydroxylases, bacterial CrtZ and eukaryotic CrtR and BCH have similarities, whereas cyanobacterial CrtR appears to belong to another clade...
  66. Sessions K, Wheeler L, Shah A, Farrell D, Agaba E, Kuule Y, et al. Mental illness in Bwindi, Uganda: Understanding stakeholder perceptions of benefits and barriers to developing a community-based mental health programme. Afr J Prim Health Care Fam Med. 2017;9:e1-e7 pubmed publisher
    ..Bwindi Community Hospital (BCH) in south-west Uganda provides services through a team of community health workers to people in the Kanungu ..
  67. Caloca M, Garcia Bermejo M, Blumberg P, Lewin N, Kremmer E, Mischak H, et al. beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S A. 1999;96:11854-9 pubmed
    ..Our results demonstrate that beta2-chimaerin is a high affinity receptor for DAG through binding to its C1 domain and supports the emerging concept that multiple pathways transduce signaling through DAG and the phorbol esters. ..
  68. Takeuchi S, Yamaki N, Iwasato T, Negishi M, Katoh H. Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 2009;583:1237-42 pubmed publisher
    ..These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration. ..
  69. Hu C, Zhang R, Yu W, Wang J, Wang C, Pang C, et al. CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients. Diabetes. 2011;60:3085-9 pubmed publisher
    ..Fifty-five SNPs from four loci (CPVL/CHN2, FRMD3, CARS, and IRS2) were genotyped...
  70. Fame R, Dehay C, Kennedy H, Macklis J. Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017;27:1817-1830 pubmed publisher
    ..g., epha3, chn2)...
  71. Casado Medrano V, Barrio Real L, Garcia Rostan G, Baumann M, Rocks O, Caloca M. A new role of the Rac-GAP ?2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Oncotarget. 2016;7:28301-19 pubmed publisher
    ..Overall, our data redefine the role of ?2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression. ..
  72. O Callaghan Gordo C, Casabonne D, Carrilho C, Ferro J, Lorenzoni C, Zaqueu C, et al. Incidence of Endemic Burkitt Lymphoma in Three Regions of Mozambique. Am J Trop Med Hyg. 2016;95:1459-1462 pubmed
    ..from reports of the three main hospitals of Mozambique: Maputo Central Hospital (MCH), Beira Central Hospital (BCH), and Nampula Central Hospital (NCH) between 2004 and 2014...
  73. Domínguez Vías G, Segarra A, Martínez Cañamero M, Ramírez Sánchez M, Prieto I. Influence of a Virgin Olive Oil versus Butter Plus Cholesterol-Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats. Int J Mol Sci. 2017;18: pubmed publisher
    ..1%) (bch)...
  74. Ragogna P, Graham C, Millet C, Price A, Valijus J, Cowley M, et al. Preparation and characterization of P2BCh ring systems (Ch = S, Se) and their reactivity with N-heterocyclic carbenes. Chemistry. 2017;: pubmed publisher
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    ..In the mouse weaver mutant lacking mature granule cells, there is a corresponding decrease in beta 2-chimaerin, which could well serve as a marker of granule cell differentiation. ..
  76. Caloca M, Fernandez N, Lewin N, Ching D, Modali R, Blumberg P, et al. Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J Biol Chem. 1997;272:26488-96 pubmed
    ..The expansion of the family of phorbol ester receptors strongly suggests a potential for the "non-kinase" receptors as cellular mediators of the phorbol ester responses. ..
  77. Caloca M, Wang H, Delemos A, Wang S, Kazanietz M. Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem. 2001;276:18303-12 pubmed
    ..The identification of selective ligands for each phorbol ester receptor class represents an important step in dissecting their specific cellular functions. ..
  78. Wang H, Yang C, Leskow F, Sun J, Canagarajah B, Hurley J, et al. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006;25:2062-74 pubmed
    ..Our results represent the first direct evidence of divergence in DAG signaling downstream of a tyrosine-kinase receptor via a PKC-independent mechanism. ..
  79. Chen M, Lin W, Lu C, Chen C, Huang Y, Liao W, et al. Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients. J Diabetes Complications. 2014;28:460-3 pubmed publisher
    To investigate whether chimerin 2 (CHN2) genetic polymorphisms were associated with the susceptibility to diabetic retinopathy (DR) in Taiwanese individuals with type 2 diabetes...
  80. Hinz K, Neef D, Rutz C, Furkert J, Köhrle J, Schulein R, et al. Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids. Mol Cell Endocrinol. 2017;443:163-174 pubmed publisher
    ..3,3'-T2 import and focus here on import and export capacity for AA, T4, T3, BCH and derivatives thereof to delineate molecular features...
  81. Xu C, Yang Y, Wang Y, Yan J, Qian L. Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer. Oncotarget. 2017;8:22483-22489 pubmed publisher
    ..In conclusion, measurement of chemerin might be a useful diagnostic and prognostic biomarker for NSCLC patients. ..
  82. Zahedi E, Shaabani S, Shiroudi A. Following the Molecular Mechanism of Decarbonylation of Unsaturated Cyclic Ketones Using Bonding Evolution Theory Coupled with NCI Analysis. J Phys Chem A. 2017;121:8504-8517 pubmed publisher
    ..2.1]hept-2-en-7-one BCH by using hybrid functional MPWB1K in conjugation with aug-cc-pVTZ basis set...
  83. Nielsen C, Bjerg M, Ulaganathan N, Holm R. Oral and intravenous pharmacokinetics of taurine in sprague-dawley rats: the influence of dose and the possible involvement of the proton-coupled amino acid transporter, PAT1, in oral taurine absorption. Physiol Rep. 2017;5: pubmed publisher
    ..that is, 200 mg/kg proline (Pro) and sarcosine (Sar), and in the presence of 2-Amino-2-norbornanecarboxylic acid (BCH) (200 mg/kg)...
  84. Duarte González M, Echeverri O, Guevara J, Palazzo R. Cyclic Concatenated Genetic Encoder: A mathematical proposal for biological inferences. Biosystems. 2018;163:47-58 pubmed publisher
    ..A methodology for representing or identifying proteins by use of BCH codes over ?20 and F4×?5 is proposed and cytochrome b6-f complex subunit 6-OS ..
  85. Yuan S, Miller D, Barnett G, Hahn J, Williams B. Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. Cancer Res. 1995;55:3456-61 pubmed
    ..The down-regulation of beta 2-chimaerin expression in the high-grade gliomas suggests that decreased expression of this gene may be a feature of progression in the development of malignant glioma. ..
  86. Wang H, Kazanietz M. Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain. J Biol Chem. 2002;277:4541-50 pubmed
    ..In this setting, Tmp21-I serves as an anchoring protein that determines the intracellular localization of these novel phorbol ester receptors. ..
  87. Griner E, Caino M, Sosa M, Colon Gonzalez F, Chalmers M, Mischak H, et al. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010;285:16931-41 pubmed publisher
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    ..With small effect sizes expected in such complex traits, future studies may be able to capitalise on power by searching for 'generalist genes' using longitudinal and multivariate approaches. ..
  89. Naylor M, Weiss S, Lange C. A Bayesian approach to genetic association studies with family-based designs. Genet Epidemiol. 2010;34:569-74 pubmed publisher
    ..We then applied the approach to a genome-wide association scan to search for associations between single nucleotide polymorphisms and body mass index in the Childhood Asthma Management Program data. ..
  90. Finalet Ferreiro J, Rouhigharabaei L, Urbankova H, van der Krogt J, Michaux L, Shetty S, et al. Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma. PLoS ONE. 2014;9:e102977 pubmed publisher
    ..Instead, loss of 7p22.1p14.1 correlated with an enhanced expression of CHN2 (7p14.1) and the encoded ?2-chimerin. Gain and amplification of 7q22.11q31...
  91. Alvi M, McArt D, Kelly P, Fuchs M, Alderdice M, McCabe C, et al. Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility. Oncotarget. 2015;6:20863-74 pubmed
    ..01). Merging gene expression and DNA methylation data revealed CHN2 as consistently hypermethylated and downregulated in this disease (Spearman -0.71, p < 0.001)...
  92. Fornes F, Belda R, Fernández de Córdova P, Cebolla Cornejo J. Assessment of biochar and hydrochar as minor to major constituents of growing media for containerized tomato production. J Sci Food Agric. 2017;97:3675-3684 pubmed publisher
    ..The characteristics of coir mixed with 0%, 10%, 25%, 50%, 75%, and 100% (v/v) of two biochars, from forest waste (BCH-FW) and from olive mill waste (BCH-OMW), and one hydrochar, from forest waste (HYD-FW), and their effects on growth,..