CHN2

Summary

Gene Symbol: CHN2
Description: chimerin 2
Alias: ARHGAP3, BCH, CHN2-3, RHOGAP3, beta-chimaerin, beta-chimerin, beta3-chimaerin, chimerin (chimaerin) 2, chimerin, beta-2, chimerin, testis-specific, rho-GTPase-activating protein 3
Species: human

Top Publications

  1. ncbi Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression
    Mieko Nishiu
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 93:894-901. 2002
  2. ncbi Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells
    María Siliceo
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Cantoblanco, E 28049 Madrid, Spain
    J Cell Sci 119:141-52. 2006
  3. pmc T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells
    María Siliceo
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, E 28049 Madrid, Spain
    J Biol Chem 284:11354-63. 2009
  4. pmc Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling
    Maria Jose Caloca
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Cell Signal 20:758-70. 2008
  5. pmc Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes
    Shiro Maeda
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Japan
    Diabetes 59:2075-9. 2010
  6. ncbi Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes
    A D Dunn
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908
    Endocrinology 128:3073-80. 1991
  7. ncbi Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 1018:272-82. 2004
  8. ncbi Comparative evaluation of L-Fd4C and related nucleoside analogs as promising antiviral agents
    Shu Hui Chen
    Vion Pharmaceuticals, Inc, Four Science Park, New Haven, CT 06511, USA
    Curr Med Chem 9:899-912. 2002
  9. pmc Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase
    Chang Guo Zhan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Am Chem Soc 125:2462-74. 2003
  10. ncbi Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier
    Andreas Reichel
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    J Drug Target 10:277-83. 2002

Research Grants

  1. Rannar Airik; Fiscal Year: 2014
  2. MATTHEW DYLAN TISDALL; Fiscal Year: 2014
  3. Powered Knee Prosthesis Incorporating Battery-Capacitor Hybrid
    BADAWI M DWEIK; Fiscal Year: 2012
  4. ALYNA TUNG MEI CHIEN; Fiscal Year: 2014
  5. SHORT-CHAIN ACYLCARNITINES--FUNCTION AND ENZYMOLOGY
    LORAN BIEBER; Fiscal Year: 1993
  6. CONTROLLED STUDY OF INFANT HIV ENCEPHALOPATHY
    David Coulter; Fiscal Year: 1992
  7. Life Stories for Black Youth: Exploring Cultural Heritage through Storytelling
    Amanda Harrell; Fiscal Year: 2009
  8. RACIVIR FOR TREATMENT OF HEPATITIS B AND HIV INFECTIONS
    Michael Otto; Fiscal Year: 2000
  9. DEVELOPMENT OF A HAWAII AIDS CLINICAL TRIALS UNIT
    MARGO HEATH CHIOZZI; Fiscal Year: 1992
  10. TRIAL OF INTERVENTIONS TO REDUCE ASTHMA MORBIDITY
    GEORGE O CONNOR; Fiscal Year: 2001

Detail Information

Publications218 found, 100 shown here

  1. ncbi Microarray analysis of gene-expression profiles in diffuse large B-cell lymphoma: identification of genes related to disease progression
    Mieko Nishiu
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 93:894-901. 2002
    ..Increased expression of MPHOSPH1, RUVBL1, CHN2, PSA and CDC10 genes, and reduced expression of COL1A2, COL4A1, FBLN5, CLECSF6, MIC2, CAV1 and S100A10 genes in the ..
  2. ncbi Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells
    María Siliceo
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Cantoblanco, E 28049 Madrid, Spain
    J Cell Sci 119:141-52. 2006
    ..These studies demonstrate that beta2-chimaerin provides a novel, diacylglycerol-dependent mechanism for Rac regulation in T cells and suggest a functional role for this protein in Rac-mediated cytoskeletal remodeling...
  3. pmc T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells
    María Siliceo
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, E 28049 Madrid, Spain
    J Biol Chem 284:11354-63. 2009
    ..This study establishes the existence of TCR-dependent regulation of beta2-chimaerin and identifies a novel mechanism for its inactivation...
  4. pmc Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling
    Maria Jose Caloca
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Cell Signal 20:758-70. 2008
    ..Taken together, these results identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells...
  5. pmc Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes
    Shiro Maeda
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Japan
    Diabetes 59:2075-9. 2010
    ..In this study, we determined the association of the four loci with diabetic nephropathy in Japanese subjects with type 2 diabetes...
  6. ncbi Proteolytic processing of thyroglobulin by extracts of thyroid lysosomes
    A D Dunn
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908
    Endocrinology 128:3073-80. 1991
    ..Using pepstatin to inhibit cathepsin D, Z-Phe-Ala-CHN2 to inhibit both cathepsin B and L, and Z-Phe-Phe-CHN2 to selectively inhibit cathepsin L, we obtained the following ..
  7. ncbi Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats
    Wiliam A Prado
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Brain Res 1018:272-82. 2004
    ..used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced ..
  8. ncbi Comparative evaluation of L-Fd4C and related nucleoside analogs as promising antiviral agents
    Shu Hui Chen
    Vion Pharmaceuticals, Inc, Four Science Park, New Haven, CT 06511, USA
    Curr Med Chem 9:899-912. 2002
    ..The recent FDA approval of Lamivudine [L-BCH 189 (3TC)] for the treatment of HIV and HBV further supports these notions...
  9. pmc Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase
    Chang Guo Zhan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Am Chem Soc 125:2462-74. 2003
    ..for (-)-cocaine and (+)-cocaine are all similar to that of the corresponding prereactive BChE/butyrylcholine (BCh) complex...
  10. ncbi Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier
    Andreas Reichel
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College London, UK
    J Drug Target 10:277-83. 2002
    ..inhibition by large neutral amino acids (LNAA) such as L-phenylalanine and 2-aminobicyclo-heptanecarboxylic acid (BCH), whereas small neutral, basic and acidic amino acids had no significant effect...
  11. ncbi Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells
    Do Kyung Kim
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Tokyo 181 8611, Mitaka, Japan
    Biochim Biophys Acta 1565:112-21. 2002
    ..of [14C]L-leucine by T24 cells is Na(+)-independent and almost completely inhibited by system L selective inhibitor BCH. The profiles of the inhibition of [14C]L-leucine uptake by amino acids and amino acid-related compounds in T24 ..
  12. ncbi Cysteine proteinase plays a key role for the initiation of yolk digestion during development of Xenopus laevis
    N Yoshizaki
    Department of Biological Diversity, Faculty of Agriculture, Gifu University, Japan
    Dev Growth Differ 40:659-67. 1998
    ..8. These activities were completely inhibited by a mixture of pepstatin A and Z-Phe-Phe-CHN2, thus being identifiable as cathepsin D and cysteine proteinase...
  13. ncbi Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea
    Blisse Jain-Vakkalagadda
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri 64110 2499, USA
    Invest Ophthalmol Vis Sci 44:2919-27. 2003
    ..The objective of this research was to investigate the presence of an Na(+)-independent, large neutral amino acid transporter, LAT1, on rabbit corneal epithelium and human cornea...
  14. ncbi Acute exposure to methylmercury causes Ca2+ dysregulation and neuronal death in rat cerebellar granule cells through an M3 muscarinic receptor-linked pathway
    Tobi L Limke
    Department of Pharmacology and Toxicology, Institute for Environmental Toxicology, and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 80:60-8. 2004
    ..or down-regulation of muscarinic receptors and inositol-1,3,4-triphosphate (IP3) receptors with bethanechol (BCh) caused similar reductions in the amplitude of the MeHg-induced Ca2+ increase, suggesting that MeHg interacts with ..
  15. ncbi Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells
    Sheng Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Cell Physiol 292:C1263-71. 2007
    ..2.1)heptane-2-carboxylic acid (BCH) and by large neutral amino acids demonstrating functional system L transporters in each cell type...
  16. ncbi In vitro characterization of the thyroidal uptake of O-(2-[(18)F]fluoroethyl)-L-tyrosine
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, D 91054 Erlangen, Germany
    Nucl Med Biol 34:305-14. 2007
    ..We therefore studied several factors potentially governing the uptake of FET in the rat thyroid cell line FRTL-5 in comparison with thyroid tumor cell lines of human origin...
  17. ncbi Comparative study of a novel nucleoside analogue (Troxatyl, troxacitabine, BCH-4556) and AraC against leukemic human tumor xenografts expressing high or low cytidine deaminase activity
    H Gourdeau
    BioChem Pharma Inc, 275 Armand Frappier Blvd, Laval, Quebec H7V 4A7, Canada
    Cancer Chemother Pharmacol 47:236-40. 2001
    Troxacitabine (beta-L-dioxolane cytidine, BCH-4556; Troxatyl, BioChem Pharma Inc.) is a novel nucleoside analogue, which in experiments demonstrated potent antitumor activity against both leukemias and solid tumors...
  18. ncbi Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria
    H Ronald Zielke
    Department of Pediatrics, University of Maryland, Pediatric Research, 10 035 BRB, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Neurochem Int 40:347-54. 2002
    ..to determine the immediate effect of infused phenylalanine, tyrosine, 2-amino-2-norborane-carboxylic acid (BCH), and leucine and alpha-ketoisocaproate on extracellular levels of LNAA...
  19. ncbi Career development among residents completing primary care and traditional residencies in medicine at the Boston City Hospital, 1974-1983
    R A Witzburg
    Department of Medicine, Boston City Hospital, Boston University School of Medicine, Massachusetts 02118
    J Gen Intern Med 3:48-53. 1988
    A primary care (PC) pathway was initiated within the medical residency program at Boston City Hospital (BCH) in 1974...
  20. pmc Hierarchical regulation of photosynthesis gene expression by the oxygen-responsive PrrBA and AppA-PpsR systems of Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 190:8106-14. 2008
    ..proteins of the photosynthetic complexes, and to indirectly upregulate the photopigment biosynthesis genes bch and crt...
  21. ncbi Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini
    Natthawut Kaewpitoon
    Graduate School, Khon Kaen University, Khon Kaen, Thailand
    Parasitol Res 102:757-64. 2008
    ..0 and the activity was inhibited by the class-specific inhibitors, E-64 and Z-Ala-CHN2. Chromatographic purification of O...
  22. ncbi System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
    Do Kyung Kim
    Department of Oral Physiology, Chosun University College of Dentistry, 375 Seosuk dong, Dong Gu, Gwangju, 501 759, South Korea
    Neurosci Res 50:437-46. 2004
    ..and C6 glioma cells were Na+-independent and were completely inhibited by the system l selective inhibitor, BCH. These results suggest that the transport of neutral amino acids including several essential amino acids into rat ..
  23. ncbi Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan
    T Yamamoto
    Health Science Laboratory, Tezukayama University, Nara, Japan
    Brain Res Bull 52:35-8. 2000
    ..At the same time, NAR who received either BCAA or 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH, a specific inhibitor for the L-system transporter) had a considerably prolonged run time to exhaustion (by twofold)..
  24. ncbi Cleavage of immunoglobulin G by excretory-secretory cathepsin S-like protease of Spirometra mansoni plerocercoid
    Y Kong
    Department of Parasitology, College of Medicine, Chung Ang University, Seoul, Korea
    Parasitology 109:611-21. 1994
    ..butane (E-64) and 1 mM iodoacetamide (IAA), but by only 53% using the specific cathepsin L inhibitor, Z-Phe-Phe-CHN2 (5 x 10(-5) M)...
  25. ncbi L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter
    D B Shennan
    Hannah Research Institute, Ayr, Scotland, KA6 5HL, UK
    Biochim Biophys Acta 1664:206-16. 2004
    ..L-leucine uptake by MDA-MB-231 and MCF-7 cells was via a BCH-sensitive, Na+ -independent pathway...
  26. pmc Rubella reimmunization: comparative analysis of the immunoglobulin G response to rubella virus vaccine in previously seronegative and seropositive individuals
    L A Mitchell
    Department of Pathology, University of British Columbia, Vancouver, Canada
    J Clin Microbiol 34:2210-8. 1996
    ..Three different whole-RV enzyme immunoassays (EIAs) and an epitope-specific EIA with a synthetic peptide (BCH-178c) representing a heutralization domain on the RV E1 envelope protein were used. Before vaccination, 84.2, 87...
  27. ncbi Feasibility of high-volume screening sigmoidoscopy using a flexible fiberoptic endoscope and a disposable sheath system
    P C Schroy
    Department of Medicine, Boston City Hospital, Massachusetts, USA
    Am J Gastroenterol 91:1331-7. 1996
    ....
  28. ncbi Drug resistance and drug combination features of the human immunodeficiency virus inhibitor, BCH-10652 [(+/-)-2'-deoxy-3'-oxa-4'-thiocytidine, dOTC]
    D L Taylor
    Virogen Drug Discovery Ltd, Mill Hill, London, UK
    Antivir Chem Chemother 11:291-301. 2000
    The heterosubstituted nucleoside analogue dOTC [( )-2'-deoxy-3'-oxa-4'-thiocytidine, BCH-10652] is a racemic compound structurally related to 3TC (lamivudine), but has the oxygen and sulphur in the furanosyl ring transposed...
  29. doi Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome
    Jason R Treberg
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Am J Physiol Endocrinol Metab 298:E1219-25. 2010
    ..2-Aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) is a nonmetabolizable analog of the natural GDH allosteric activator leucine...
  30. ncbi Airway generation-dependent induction of muscarinic hyperresponsiveness by thromboxane mimetic in vitro
    L W Barger
    Department of Physiology and Biophysics, University of Vermont, Burlington 05405
    Am Rev Respir Dis 144:64-9. 1991
    ..Dose-response curves to the muscarinic agonist bethanechol (BCh) alone were compared with responses to BCh plus U46619...
  31. ncbi Didanosine in the treatment of AIDS and AIDS-related complex: a critical appraisal of the dose and frequency of administration
    H A Liebman
    Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Clin Infect Dis 16:S52-8. 1993
    ..School of Medicine and the University of Rochester School of Medicine, and by researchers at Boston City Hospital (BCH)...
  32. ncbi Rubella virus vaccine associated arthropathy in postpartum immunized women: influence of preimmunization serologic status on development of joint manifestations
    L A Mitchell
    Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    J Rheumatol 27:418-23. 2000
    ..To measure preimmunization rubella virus (RV)-specific IgG levels and to relate these to the development of acute and chronic (persistent or recurrent) joint manifestations following rubella vaccination...
  33. ncbi Progress on molecular breeding and metabolic engineering of biosynthesis pathways of C(30), C(35), C(40), C(45), C(50) carotenoids
    Fei Wang
    College of Food and Bioengineering, South China University of Technology, Guangzhou, PR China
    Biotechnol Adv 25:211-22. 2007
    ..by lycopene cyclase (CrtY or LYC) and other modifications by different modifying enzyme (CrtA, CrtU, CrtZ or BCH, CrtX, CrtO, etc.) of this C(40) backbone...
  34. doi System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line
    Kohichi Yamauchi
    Department of Otolaryngology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Cancer Lett 276:95-101. 2009
    ..An inhibitor of system L, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), inhibited leucine uptake by the cells...
  35. ncbi Basal cell hyperplasia, adenoid basal cell tumor, and adenoid cystic carcinoma of the prostate gland: an immunohistochemical study
    D J Grignon
    Department of Pathology, University of Texas M D Anderson Hospital and Tumor Institute, Houston 77030
    Hum Pathol 19:1425-33. 1988
    Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland...
  36. ncbi Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells
    M Barreto
    , Centro Asociado al Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Horm Metab Res 21:533-6. 1989
    ..metabolite 2-ketoisocaproate and its nonmetabolized analogue b(+/-)2-aminobicyclo[2,2,1]-heptane-2-carboxylic acid (BCH) upon protein labelling was examined in tumoral islet cells (RINm5F line) exposed to L-[4-3H]phenylalanine or L-[3-..
  37. pmc appA, a novel gene encoding a trans-acting factor involved in the regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1
    M Gomelsky
    Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston 77030, USA
    J Bacteriol 177:4609-18. 1995
    ..This result indicated that AppA is more likely involved in the regulation of expression of the bch genes than in the biosynthetic pathway per se...
  38. ncbi Antithrombotic effects of BCH 2763, a new direct thrombin inhibitor, in a canine model of venous thrombosis
    T B McClanahan
    Cardiovascular Therapeutics and Biometrics Sections, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    J Thromb Thrombolysis 7:301-6. 1999
    ..b>BCH 2763 is a potent, selective bifunctional thrombin inhibitor that blocks both the active catalytic site and the ..
  39. ncbi Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2
    B C Low
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, 30 Medical Dr, Singapore 117609, Republic of Singapore
    J Biol Chem 275:14415-22. 2000
    ..which includes the region of homology to the noncatalytic domain of Cdc42GAP, termed BNIP-2 and Cdc42GAP homology (BCH) domain...
  40. pmc Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles
    Y Kudo
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    J Physiol 531:405-16. 2001
    ..and is completely abolished by the L-system-specific substrate 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH)...
  41. pmc The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants
    Y Kudo
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    J Physiol 531:417-23. 2001
    ..and is substantially inhibited by the L-system-specific substrate 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) and also by 1-methyl-tryptophan which is also an inhibitor of indoleamine 2,3-dioxygenase...
  42. ncbi Intervention and follow-up on human esophageal precancerous lesions in Henan, northern China, a high-incidence area for esophageal cancer
    Li Dong Wang
    Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou, Henan, 450052, People s Republic of China
    Gan To Kagaku Ryoho 29:159-72. 2002
    ..Human esophageal carcinogensis has been considered as a multistep progressive process. The natural history for EC, however is not very clear...
  43. ncbi p53 Gene mutation and genetic instability in superficial multifocal esophageal squamous cell carcinoma
    Takehiro Fujiki
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Oncol 20:669-79. 2002
    ..A total of 38 target areas (TAs) were analyzed in SCC, dysplasia, basal cell hyperplasia (BCH) and normal squamous epithelium...
  44. ncbi Thiobaca trueperi gen. nov., sp. nov., a phototrophic purple sulfur bacterium isolated from freshwater lake sediment
    Gavin N Rees
    University of Canberra and CRCFE Murray Darling Freshwater Research Centre, Albury, NSW, Australia
    Int J Syst Evol Microbiol 52:671-8. 2002
    ..Photolithoautotrophic growth was not observed. One strain was designated BCH(T) (the type strain) and was studied in most detail...
  45. ncbi Bacteriochlorophyll-dependent expression of genes for pigment-binding proteins in Rhodobacter capsulatus involves the RegB/RegA two-component system
    E M Abada
    Institut fur Mikrobiologie und Molekularbiologie, Universitat Giessen, Heinrich Buff Ring 26 32, Germany
    Mol Genet Genomics 267:202-9. 2002
    ..In strains lacking bacteriochlorophyll (Bchl) due to mutations in bch genes, the rise in puf and puc mRNA levels observed on reduction of oxygen tension is much less pronounced than in ..
  46. ncbi A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2
    D B Shennan
    Hannah Research Institute, Ayr Scotland, UK
    Biochim Biophys Acta 1564:133-9. 2002
    ..The peak clearance of L-leucine was inhibited by BCH (65%) and D-leucine (58%) but not by L-proline...
  47. ncbi Phase II study of troxacitabine (BCH-4556) in patients with advanced and/or metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada-Clinical Trials Group
    C A Townsley
    Department of Medical Oncology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    J Clin Oncol 21:1524-9. 2003
    ....
  48. ncbi Complementary antineoplastic activity of the cytosine nucleoside analogues troxacitabine (Troxatyl) and cytarabine in human leukemia cells
    David Y Bouffard
    Shire BioChem Inc, 275 Armand Frappier Blvd, Laval, Quebec, H7V 4A7, Canada
    Cancer Chemother Pharmacol 52:497-506. 2003
    Troxacitabine (BCH-4556, l-(-)-OddC, Troxatyl) is a novel beta- l-nucleoside analogue with potent antineoplastic activity both in vitro and in several tumor models in vivo, and is presently in phase II clinical trials...
  49. ncbi Identification and functional characterization of a Na(+)-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells
    Mohit D Gandhi
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110 2499, USA
    Int J Pharm 275:189-200. 2004
    ..System L-specific inhibitor BCH produced partial inhibition of uptake. Neither acidic nor basic amino acids altered the uptake rate...
  50. ncbi High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells
    Patricio Soares-da-Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
    Am J Physiol Renal Physiol 287:F252-61. 2004
    ..to N-(methylamino)-isobutyric acid but competitively inhibited by 2-aminobicyclo(2,2,1)-heptane-2-carboxylic acid (BCH)...
  51. ncbi Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis
    Daniel T Merrick
    Department of Pathology, Denver Veteran s Affairs Medical Center, 1055 Clermont St, Denver, CO 80220, USA
    Lung Cancer 48:31-45. 2005
    ..and microvessel densities (MVDs) in 62 bronchoscopic biopsies from normal, reactive (basal cell hyperplasia (BCH)) and dysplastic bronchial epithelium and in tissue from twenty-seven invasive lung carcinomas in an effort to ..
  52. ncbi Amino acid transport system L is differently expressed in human normal oral keratinocytes and human oral cancer cells
    Jung Hoon Yoon
    Oral Biology Research Institute, Chosun University College of Dentistry, Gwangju 501 759, Korea
    Cancer Lett 222:237-45. 2005
    ..The [14C] L-leucine uptake by HNOK, as well as KB cells, was inhibited by the system L selective inhibitor BCH. The majority of [14C] L-leucine uptake was, therefore, mainly mediated by LAT2 in the HNOK and by LAT1 in the KB ..
  53. ncbi cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1
    Li Xie
    Shanghai Medical College, Fudan University, Shanghai 200032, China
    Acta Biochim Biophys Sin (Shanghai) 37:618-24. 2005
    ..laboratory, which can interact with Bcl-2 and Cdc42GAP and induce apoptosis via the BNIP-2 and Cdc42GAP homology (BCH) domain...
  54. ncbi L-serine uptake by human placental microvillous membrane vesicles
    R M Lewis
    Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
    Placenta 28:445-52. 2007
    ..into microvillous membrane (MVM) vesicles was primarily mediated by system A (MeAIB inhibitable) and system L (BCH inhibitable)...
  55. ncbi Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist
    Anders Larsson
    Orebro Life Science Center, Department of Natural Sciences, Orebro University, SE 701 82 Orebro, Sweden
    J Med Chem 49:7366-72. 2006
    ..Flexible alignment studies of the BFR compounds demonstrated that 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (BCH) closely overlap DHT...
  56. ncbi Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney
    Maria João Pinho
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal
    Am J Physiol Regul Integr Comp Physiol 293:R538-47. 2007
    ..In the presence of the system L inhibitor BCH, Na(+)-dependent l-alanine uptake in WKY and SHR PTE cells was inhibited by alanine, serine, and cysteine, which is ..
  57. pmc High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors
    Ming Li
    Donald Danforth Plant Science Center, 975 North Warson Road, St Louis, Missouri 63132, USA
    Biochemistry 46:15089-102. 2007
    ..a dominant mutation causes the loss of inhibition by GTP, and from studies that link leucine (and its analogue BCH) activation of GDH to stimulation of insulin secretion...
  58. pmc Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion
    Michael J MacDonald
    Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Biochim Biophys Acta 1780:966-72. 2008
    ..that contrasting leucine with its non-metabolizable analog 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) might provide new information about metabolic pathways involved in insulin secretion...
  59. doi Novel micro3-oxo complexes prepared from Cp*Zr(B(3R)3 (R = H, CH3) and B(C6F5)3 in diethyl ether
    Fu Chen Liu
    Department of Chemistry, National Dong Hwa University, Hualien, 974, Taiwan, ROC
    Dalton Trans . 2008
    ..ether produced the novel 14-electron ionic compounds [(micro(3)-O)(micro(2)-OC(2)H(5))(3){(Cp*Zr(OC(2)H(5)))(2)(BCH(3))}][HB(C(6)F(5))(3)], 4, and [(micro(3)-O)(micro(2)-OC(2)H(5))(3){(Cp*Zr(OC(2)H(5)))(2)(BOC(2)H(5))}][HB(C(6)F(5))..
  60. doi Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma
    Wing Lam
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cancer Ther 8:415-23. 2009
    Beta-L-dioxolane-cytidine (L-OddC; BCH-4556; troxacitabine), a novel L-configuration deoxycytidine analogue, was under clinical trials for treating cancer...
  61. pmc From QTL to candidate gene: genetical genomics of simple and complex traits in potato using a pooling strategy
    Bjorn Kloosterman
    Wageningen UR Plant Breeding, Wageningen University and Research Centre, PO Box 386, 6700 AJ Wageningen, The Netherlands
    BMC Genomics 11:158. 2010
    ..Extreme genotypes for a quantitative trait are collected and the RNA from contrasting bulks is then profiled with the aim of finding differentially expressed genes...
  62. doi A gene duplication/loss event in the ribulose-1,5-bisphosphate-carboxylase/oxygenase (rubisco) small subunit gene family among accessions of Arabidopsis thaliana
    Sandra Schwarte
    Evolutionary Biology, Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany
    Mol Biol Evol 28:1861-76. 2011
    ..In summary, we found the gene duplication/loss in 8 of 100 A. thaliana accessions, namely, Bch, Bu, Bur, Cvi, Fei, Lm, Sha, and Sorbo. We sequenced an about 1-kb promoter region for all Rubisco genes as well...
  63. pmc Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants
    Yan Lu
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 155:1589-600. 2011
    ..b>bch.msu.edu/2010_LIMS; www.plastid.msu.edu)...
  64. doi Modeling of cellular arginine uptake by more than one transporter
    Marietha J Nel
    Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
    J Membr Biol 245:1-13. 2012
    ..N-Ethylmaleimide inhibited only y⁺ transport, and BCH may be a selective inhibitor of y⁺L transport...
  65. pmc Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP
    Simon Mead
    MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Hum Mol Genet 21:1897-906. 2012
    ..A SNP in the CHN2 gene was associated with vCJD [P = 1.5 × 10(-7); odds ratio (OR), 2.36], but not in UK sCJD (P = 0.049; OR, 1...
  66. pmc Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily
    Anjali Bansal Gupta
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e33863. 2012
    ..We have previously demonstrated that the BNIP-2 and Cdc42GAP Homology (BCH) protein domain, which shares a low sequence homology with the CRAL_TRIO domain, can serve as a regulatory scaffold ..
  67. doi Inequalities in usage of a public bicycle sharing scheme: socio-demographic predictors of uptake and usage of the London (UK) cycle hire scheme
    F Ogilvie
    Public Health and Policy, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Prev Med 55:40-5. 2012
    Cycling confers individual and population-level health benefits, but uptake is not always equitable across socio-demographic groups. We sought to examine inequalities in uptake and usage of London's Barclays Cycle Hire (BCH) scheme.
  68. doi Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics
    Catherine Qiurong Pan
    MechanoBiology Institute Singapore, 5A Engineering Drive 1, National University of Singapore, 117411 Singapore, Singapore
    FEBS Lett 586:2674-91. 2012
    The BNIP-2 and Cdc42GAP Homology (BCH) domains constitute a new and expanding family of highly conserved scaffold protein domains that regulate Rho, Ras and MAPK signaling, leading to cell growth, apoptosis, morphogenesis, migration and ..
  69. pmc Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America Diabetes Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 9:e88273. 2014
    ..Nominal signals were observed in AGTR1, RPS12, CHN2 and CNDP1. Additional adjustment for APOL1 G1/G2 risk variants attenuated association at MYH9 (P(emp) = 0...
  70. doi Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS
    Wei Liu
    Institute of Chinese Materia Medica, Shanghai 201203, China
    J Pharm Biomed Anal 94:215-20. 2014
    ..0035 and 0.008unitmL(-1) for AChE and BChE, and substrates of 5.505 and 7.152μM for ACh and BCh in individual inhibition, respectively), and without matrix effect (90.00-105.03%)...
  71. doi Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: implications for drug access to cytoplasmic targets
    James E Biggs
    Neurosciences and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Neurosci Lett 584:397-402. 2015
    ..with an inhibitor of the neutral amino acid transporter, 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH 300 μM), showed the actions of GBP seen in the presence of capsaicin were independent of its entry by this route...
  72. pmc BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis
    Y Tatsumi
    1 Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chuoh ku, Chiba 260 8717, Japan 2 Children s Cancer Research Center, Chiba Cancer Center Research Institute, Chuoh ku, Chiba 260 8717, Japan
    Cell Death Dis 6:e1607. 2015
    BNIP2 and Cdc42GAP homology (BCH) motif-containing molecule at the carboxyl-terminal region 1 (BMCC1) gene is highly expressed in patients with favorable neuroblastoma (NB)...
  73. pmc Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility
    Muhammad A Alvi
    Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland, UK
    Oncotarget 6:20863-74. 2015
    ..01). Merging gene expression and DNA methylation data revealed CHN2 as consistently hypermethylated and downregulated in this disease (Spearman -0.71, p < 0.001)...
  74. doi Silver(I)-Catalyzed N-Trifluoroethylation of Anilines and O-Trifluoroethylation of Amides with 2,2,2-Trifluorodiazoethane
    Haiqing Luo
    Beijing National Laboratory of Molecular Sciences BNLMS and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 China
    Angew Chem Int Ed Engl 54:14503-7. 2015
    ..of anilines has been developed based on silver-catalyzed NH insertions with 2,2,2-trifluorodiazoethane (CF3 CHN2 ). Mechanistically, the reaction is proposed to involve migratory insertion of a silver carbene as the key step...
  75. doi Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?
    Shirin Pournourmohammadi
    Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel Servet, 1206 Geneva, Switzerland Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel Servet, 1206 Geneva, Switzerland
    Int J Biochem Cell Biol . 2017
    ..by EGCG upon glucose stimulation and blocked in response to glutamine combined with the allosteric GDH activator BCH (2-aminobicyclo-[2,2,1] heptane-2-carboxylic acid)...
  76. ncbi The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors
    M J North
    Department of Biological and Molecular Sciences, School of Natural Sciences, University of Stirling, U K
    Mol Biochem Parasitol 39:183-93. 1990
    ..The other proteinases were inhibited by low concentrations of E-64 and by Z-Phe-Ala-CHN2, and to a lesser extent by Z-Phe-Phe-CHN2. Differences between the proteinases of T. foetus were also demonstrated...
  77. ncbi Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrier
    M M Sanchez del Pino
    Department of Physiology and Biophysics, Finch University of Health Sciences, Chicago Medical School, Illinois 60064, USA
    J Biol Chem 270:14913-8. 1995
    ..values) toward leucine (17 +/- 3 microM), tryptophan (8 +/- 1), 2-aminobicyclo(2,2,1)-heptane-2-carboxylic acid (BCH) (11 +/- 2), alanine (628 +/- 117), and glutamine (228 +/- 51)...
  78. ncbi Pyrido [1,2a] indole derivatives identified as novel non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
    D L Taylor
    MRC Collaborative Centre, London, UK
    Antivir Chem Chemother 10:79-86. 1999
    ..The most potent compound of the series, BCH-1, had similar antiviral activity to the licensed NNRTI nevirapine against laboratory strains of HIV-1 cultured in ..
  79. ncbi Body and intestinal growth of broiler chicks on a commercial starter diet. 3. Development and characteristics of tryptophan transport
    P A Iji
    Department of Animal Science, The University of Adelaide, Glen Osmond, Australia
    Br Poult Sci 42:523-9. 2001
    ..was lower in the presence of D-tryptophan than in the presence of 2-aminobicyclo-[2,2,1]-heptane-2-carboxylic acid (BCH). The inclusion of BCH in the incubation medium at low concentrations significantly enhanced the uptake of 0...
  80. ncbi The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    Gyslaine Bertrand
    Unité d Endocrinologie et Métabolisme, University of Louvain Faculty of Medicine, B 1200 Brussels, Belgium
    J Biol Chem 277:32883-91. 2002
    ..Allosteric activation of glutamate dehydrogenase by BCH (2-amino 2-norbornane carboxylic acid) lowered islet glutamate but increased insulin secretion...
  81. ncbi Monophyletic HIV type 1 CRF02-AG in a nosocomial outbreak in Benghazi, Libya
    Ubaldo Visco-Comandini
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 18:727-32. 2002
    ..in Libya in 1999, involving 402 children admitted to "El-Fath" Children's Hospital in Benghazi (BCH) during 1998 and 19 of their mothers...
  82. ncbi Glutamine transport in isolated epithelial intestinal cells. Identification of a Na+-dependent transport mechanism, highly specific for glutamine
    Jesús R del Castillo
    Laboratorio de Fisiologia Gastrointestinal, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas, PO Box 21827, Caracas 1020 A, Venezuela
    Pflugers Arch 445:413-22. 2002
    ..2-Aminobicyclo(2,2,1)heptane-2-carboxylate (BCH), a system B(0) and B(0,+) substrate, had no effect on Na(+)-dependent influx...
  83. ncbi BCH-1868 [(-)-2-R-dihydroxyphosphinoyl-5-(S)-(guanin-9'-yl-methyl) tetrahydrofuran]: a cyclic nucleoside phosphonate with antitumor activity
    Lorraine Leblond
    Shire BioChem, Inc, Laval, Quebec, H7V 4A7 Canada
    Mol Cancer Ther 1:737-46. 2002
    ..phosphonate analogue of guanosine, (-)-2-R-dihydroxyphosphinoyl-5-(S)-(guanin-9'-ylmethyl) tetrahydrofuran (BCH-1868), previously reported as having antiviral activity, also displays antitumor activity...
  84. ncbi Functional and molecular characteristics of system L in human breast cancer cells
    D B Shennan
    Hannah Research Institute, Ayr, Scotland KA6 5HL, UK
    Biochim Biophys Acta 1611:81-90. 2003
    ..alpha-Aminoisobutyric acid (AIB) uptake by MDA-MB-231 and MCF-7 cells was almost abolished by BCH (2-amino-2-norbornane-carboxylic acid). AIB uptake by MDA-MB-231 cells was also inhibited by L-alanine (83...
  85. ncbi Molecular and enzymatic properties of a cathepsin L-like proteinase with distinct substrate specificity from northern shrimp (Pandalus borealis)
    H Aoki
    Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
    J Comp Physiol B 174:59-69. 2004
    ..The shrimp cathepsin was strongly inhibited by E-64, leupeptin and antipain, while benzyloxycarbonyl-Phe-Tyr(t-Bu)-CHN2, a specific inhibitor of cathepsin L, remained largely ineffective...
  86. ncbi Is benign cough headache caused by intraocular haemodynamic aberration?
    Vinod Kumar Gupta
    Dubai Police Medical Services, PO Box 12005, Dubai, United Arab Emirates
    Med Hypotheses 62:45-8. 2004
    Rise of intracranial pressure (ICP) is currently presumed to underlie benign cough headache (BCH). Cough normally increases ICP but very few patients develop BCH. Children, young adults and females are rarely affected...
  87. ncbi Characterization of uptake of 3-[(131)I]iodo-alpha-methyl-L-tyrosine in human monocyte-macrophages
    Olaf Prante
    Department of Nuclear Medicine, Laboratory of Molecular Imaging, Friedrich Alexander University, Erlangen, Germany
    Nucl Med Biol 31:365-72. 2004
    ..Transport into non-stimulated HMMs was exclusively sodium-independent and inhibitable by BCH, but not by MeAIB...
  88. ncbi Renal accumulation and excretion of radioiodinated 3-iodo-alpha-methyl-L-tyrosine
    Naoto Shikano
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki Gun, Japan
    Ann Nucl Med 18:263-70. 2004
    ..We investigated mechanisms of renal accumulation of radioiodinated 3-iodo-alpha-methyl-L-tyrosine (IMT), which has been used clinically for tumor imaging and as an amino acid transport marker in studies of brain and pancreas function...
  89. ncbi Adenoid-basal cell tumor of the prostate gland. A case report: histomorphologic and immunohistochemical features
    Ozden Tulunay
    Department of Pathology, Medical School of Ankara University Ankara, Turkey
    Int Urol Nephrol 36:51-3. 2004
    ..There seems to be a morphologic continuum ranging from focal basal cell hyperplasia (BCH) to florid adenoid basal cell tumor (ABCT)...
  90. ncbi Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons
    Wojciech Rzeski
    Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie Skodowska University, Lublin, Poland
    J Neurosci Res 80:677-82. 2005
    ..system [leucine (Leu); IC50: 19 and 42 microM, respectively] and 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH; IC50: 19 and 28 microM, respectively)...
  91. ncbi Phase II study of troxacitabine (BCH-4556) in patients with advanced non-small-cell lung cancer
    S F Dent
    National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada
    Lung 183:265-72. 2005
    ..Hematologic and biochemical toxicities, grade 3/4 (%) were: granulocytopenia (41), anemia (12), thrombocytopenia (6), and hyperglycemia (6). Troxacitabine appears to have little activity in NSCLC in the dose and schedule tested...
  92. ncbi Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism
    Susanne G Straub
    The Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Diabetes Metab Res Rev 23:146-51. 2007
    ....
  93. ncbi Current targets in irritable bowel syndrome: an interview with Eamonn Quigley. Interview by Emma Quigley
    Eamonn Quigley
    Expert Opin Ther Targets 10:351-3. 2006
    ..University of Ireland in 1984 and he received his medical education at University College Cork, graduating MB BCh BAO in 1976...
  94. ncbi Nutrient control of insulin secretion in isolated normal human islets
    Jean Claude Henquin
    Unité d Endocrinologie et Métabolisme, UCL 55 30, Ave Hippocrate 55, B 1200 Brussels, Belgium
    Diabetes 55:3470-7. 2006
    ..ineffective, but its combination with leucine or nonmetabolized 2-amino-bicyclo [2,2,1]-heptane-2-carboxylic acid (BCH) evoked rapid insulin secretion. The effect of BCH was larger in low glucose than in high glucose...
  95. ncbi Cleavage of BNIP-2 and BNIP-XL by caspases
    C Alexander Valencia
    School of Pharmacy and Carolina Center for Genome Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem Biophys Res Commun 364:495-501. 2007
    BNIP-2 and BNIP-XL are BCH domain-containing proteins that are implicated in programmed cell death...
  96. ncbi Contributions to 3D diffeomorphic atlas estimation: application to brain images
    Matias Bossa
    GTC, Aragon Institute of Engineering Research I3A, University of Zaragoza, Spain
    Med Image Comput Comput Assist Interv 10:667-74. 2007
    ..In this work we propose to apply the Baker-Campbell-Hausdorff (BCH) formula instead...
  97. doi Properties of L-type amino acid transporter 1 in epidermal ovarian cancer
    Masahiko Kaji
    Department of Obstetrics and Gynecology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Int J Gynecol Cancer 20:329-36. 2010
    ....
  98. doi Textile dye degradation by bacterial consortium and subsequent toxicological analysis of dye and dye metabolites using cytotoxicity, genotoxicity and oxidative stress studies
    Swapnil S Phugare
    Department of Biochemistry, Shivaji University, Kolhapur, India
    J Hazard Mater 186:713-23. 2011
    ..Providencia sp. SDS (PS) and Pseudomonas aeuroginosa strain BCH (PA) originally isolated from dye contaminated soil...
  99. doi Epidermal basaloid cell hyperplasia overlying dermatofibromas
    Christian Fredrik Lindboe
    Department of Pathology, Sørlandet Sykehus HF, Kristiansand, Norway
    Am J Dermatopathol 33:52-5. 2011
    ..2%) with basaloid cell hyperplasia (BCH) of the overlying epidermis...
  100. doi Rifampicin-monoresistant Mycobacterium tuberculosis disease among children in Cape Town, South Africa
    A Dramowski
    Department of Paediatrics and Child Health, Tygerberg Children s Hospital, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 16:76-81. 2012
    Tygerberg Children's Hospital (TCH) and Brooklyn Chest Hospital (BCH), South Africa.
  101. pmc A novel pathway underlying the inhibitory effects of melatonin on isolated rat urinary bladder contraction
    June Hyun Han
    Department of Urology, KEPCO Medical Foundation, Han il General Hospital, Seoul 132 703, Korea
    Korean J Physiol Pharmacol 16:37-42. 2012
    ..the effects of melatonin on the contractions induced by phenylephrine (PE), acetylcholine (ACh), bethanechol (BCh), KCl, and electrical field stimulation (EFS) in 20 detrusor smooth muscle samples from Sprague-Dawley rats...

Research Grants20

  1. Rannar Airik; Fiscal Year: 2014
    ..In March 2013 I will move to the Boston Children's Hospital (BCH)/Harvard Medical School (HMS) with Dr. Hildebrandt's laboratory...
  2. MATTHEW DYLAN TISDALL; Fiscal Year: 2014
    ..phase will be performed with pediatric volunteers on the clinical MRI systems at Boston Children's Hospital (BCH)...
  3. Powered Knee Prosthesis Incorporating Battery-Capacitor Hybrid
    BADAWI M DWEIK; Fiscal Year: 2012
    ..Capacitors, while having very low energy densities, have very high power densities. In a battery/capacitor hybrid (BCH), the capacitor handles most of the power spikes, allowing the battery to function under more constant conditions...
  4. ALYNA TUNG MEI CHIEN; Fiscal Year: 2014
    ..insured by BCBSMA and cared for by primary care physicians affiliated with Boston Children's Hospital (BCH) through 72 privately-owned community-based offices located across Massachusetts and 2 BCH-owned hospital-based ..
  5. SHORT-CHAIN ACYLCARNITINES--FUNCTION AND ENZYMOLOGY
    LORAN BIEBER; Fiscal Year: 1993
    ..Rev, BCH 57, 261 (1988(]; however, the roles for CAT and COT of liver microsomes are unknown due, in part, to the limited ..
  6. CONTROLLED STUDY OF INFANT HIV ENCEPHALOPATHY
    David Coulter; Fiscal Year: 1992
    ..When their infants are born at Boston City Hospital (BCH), they will also be tested for HIV. All HIV-positive infants will form the study group (16/year)...
  7. Life Stories for Black Youth: Exploring Cultural Heritage through Storytelling
    Amanda Harrell; Fiscal Year: 2009
    ..The proposed innovative product, LifeStories for Kids: Black Cultural Heritage Series (LS-BCH), is a school- based curriculum for upper elementary children focusing on Black heritage and culture featuring ..
  8. RACIVIR FOR TREATMENT OF HEPATITIS B AND HIV INFECTIONS
    Michael Otto; Fiscal Year: 2000
    ..Unlike (+)-BCH-189 (the plus-beta- enantiomer of 3TC), (+)- FTC is essentially non-toxic in various sophisticated in vitro ..
  9. DEVELOPMENT OF A HAWAII AIDS CLINICAL TRIALS UNIT
    MARGO HEATH CHIOZZI; Fiscal Year: 1992
    ..prior ACTG experience as a co-investigator at the Beth Israel Hospital subunit of the Harvard/Boston City Hospital (BCH) ACTU. The professional and support staff necessary to conduct HIV clinical research will be recruited and trained...
  10. TRIAL OF INTERVENTIONS TO REDUCE ASTHMA MORBIDITY
    GEORGE O CONNOR; Fiscal Year: 2001
    ..receiving care in five inner-city neighborhood health centers and in the Pediatric Clinic of Boston City Hospital (BCH). Using a factorial design, subjects will be randomized to receive one, both, or neither intervention...
  11. Molecular Characterization of Cayman Ataxia, ATCAY
    Margit Burmeister; Fiscal Year: 2007
    ..The C-terminus is also homologous to a BCH (BNIP2-CDC42GAP homology) domain present in CDC42GAP-like proteins...
  12. DIABETES MELLITUS IN URBAN CARIBBEAN LATINOS
    Stuart Chipkin; Fiscal Year: 1992
    ..is home to a significant number of Caribbean Latinos who receive their health care from the Boston City Hospital (BCH) and the South End Community Health Center (SECHC)...
  13. ACADEMIC NURSING HOME
    Jay Shapiro; Fiscal Year: 1992
    ..While centered in the institutions on the Baltimore City Hospitals (BCH) campus (the Mason F...
  14. CAUSE OF CARDIOVASCULAR COMPLICATIONS IN HIV INFECTION
    Jeffrey Towbin; Fiscal Year: 2002
    ..Complications of Vertically Acquired HIV infection (P2C2 HIV) Study at BCM and Boston Children's Hospital (BCH)...
  15. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
    ..physiological mechanisms such as time-dependent potentiation and biphasic insulin release. The method will also allow the study of some aspects of endocytosis. ..
  16. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  17. Localized modulation of RPE P-gp/MRP activity for back-of-the-eye drug delivery
    Soumyajit Majumdar; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  18. RELATIONSHIP BETWEEN PROTEIN STRUCTURE AND FUNCTION
    George Hess; Fiscal Year: 2006
    ..Caged serotonin will be used in studies of the serotonin 5HT3 receptor mechanism and its inhibition. The caged indicator will be used in a screening assay of neurotransmitter receptor ligands. ..
  19. Role of Vav family proteins in cell signaling and cancer
    XOSE BUSTELO; Fiscal Year: 2009
    ..abstract_text> ..
  20. CHEMICAL REACTIONS IN TRANSMISSION OF NERVE IMPULSES
    George Hess; Fiscal Year: 2004
    ..The ligands are isolated by a technique developed by the principal investigator's laboratory. ..