Gene Symbol: CHMP1B
Description: charged multivesicular body protein 1B
Alias: C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2, Vps46B, hVps46-2, charged multivesicular body protein 1b, chromatin modifying protein 1B, chromatin-modifying protein 1b, vacuolar protein sorting 46-2, vacuolar protein sorting-associated protein 46-2
Species: human
Products:     CHMP1B

Top Publications

  1. Jouvenet N, Zhadina M, Bieniasz P, Simon S. Dynamics of ESCRT protein recruitment during retroviral assembly. Nat Cell Biol. 2011;13:394-401 pubmed publisher
  2. Shim S, Merrill S, Hanson P. Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell. 2008;19:2661-72 pubmed publisher
    ..that LIP5 binds tightly to CHMP5, but also find that it binds well to additional ESCRT-III proteins including CHMP1B, CHMP2A/hVps2-1, and CHMP3/hVps24 but not CHMP4A/hSnf7-1 or CHMP6/hVps20...
  3. Bajorek M, Schubert H, McCullough J, Langelier C, Eckert D, Stubblefield W, et al. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009;16:754-62 pubmed publisher
    ..IST1 and its ESCRT-III binding partner, CHMP1B, both form higher-order helical structures in vitro, and IST1-CHMP1 interactions are required for abscission...
  4. Strack B, Calistri A, Craig S, Popova E, Gottlinger H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003;114:689-99 pubmed
    ..These observations identify AIP1 as a component of the viral budding machinery, which serves to link a distinct region in the L domain of HIV-1 p6 and EIAV p9 to ESCRT-III...
  5. Martin Serrano J, Yarovoy A, Perez Caballero D, Bieniasz P, Yaravoy A. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:12414-9 pubmed
  6. Xiao J, Chen X, Davies B, Saltiel A, Katzmann D, Xu Z. Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell. 2009;20:3514-24 pubmed publisher
    ..This arrangement indicates a mechanism for intermolecular ESCRT-III subunit association and may also suggest one form of ESCRT-III subunit autoinhibition via intramolecular interaction. ..
  7. Rigden D, Liu H, Hayes S, Urbé S, Clague M. Ab initio protein modelling reveals novel human MIT domains. FEBS Lett. 2009;583:872-8 pubmed publisher
    ..As a proof of principle, we have confirmed the novel MIT annotation for USP54 by in vitro profiling of binding to CHMP proteins. ..
  8. Agromayor M, Carlton J, Phelan J, Matthews D, Carlin L, Ameer Beg S, et al. Essential role of hIST1 in cytokinesis. Mol Biol Cell. 2009;20:1374-87 pubmed publisher
    ..Last, we show that the hIST1 MIM activity is essential for cytokinesis, suggesting possible mechanisms to explain the role of hIST1 in the last step of mammalian cell division. ..
  9. Agromayor M, Martin Serrano J. Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo. J Biol Chem. 2006;281:23083-91 pubmed
    ..deubiquitinating enzyme, with the endodomal sorting complex required for transport (ESCRT-III) subunits CHMP1A, CHMP1B, CHMP2A, and CHMP3...

More Information


  1. Bajorek M, Morita E, Skalicky J, Morham S, Babst M, Sundquist W. Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell. 2009;20:1360-73 pubmed publisher
    ..In contrast, IST1 depletion did not inhibit human immunodeficiency virus-1 budding. Thus, IST1 and CHMP1 act together to recruit and modulate specific VPS4 activities required during the final stages of cell division. ..
  2. Renvoisé B, Parker R, Yang D, Bakowska J, Hurley J, Blackstone C. SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell. 2010;21:3293-303 pubmed publisher
    ..These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis. ..
  3. Howard T, Stauffer D, Degnin C, Hollenberg S. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. J Cell Sci. 2001;114:2395-404 pubmed
    ..These observations identify the conserved CHMP/Chmp family as a set of proteins fundamental to understanding multivesicular body sorting in eukaryotic organisms. ..
  4. von Schwedler U, Stuchell M, Muller B, Ward D, Chung H, Morita E, et al. The protein network of HIV budding. Cell. 2003;114:701-13 pubmed
    ..These studies define a protein network required for human MVB biogenesis and indicate that the entire network participates in the release of HIV and probably many other viruses. ..
  5. Reid E, Connell J, Edwards T, Duley S, Brown S, Sanderson C. The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum Mol Genet. 2005;14:19-38 pubmed
    ..Using full-length spastin as bait, we identified CHMP1B, a protein associated with the ESCRT (endosomal sorting complex required for transport)-III complex, as a binding ..
  6. Yang D, Rismanchi N, Renvoisé B, Lippincott Schwartz J, Blackstone C, Hurley J. Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol. 2008;15:1278-86 pubmed publisher
    ..The ESCRT-III protein charged multivesicular body protein 1B (CHMP1B) is required for recruitment of the MIT domain-containing protein spastin, a microtubule-..
  7. Row P, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem. 2007;282:30929-37 pubmed
    ..between the UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7...
  8. Morita E, Colf L, Karren M, Sandrin V, Rodesch C, Sundquist W. Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A. 2010;107:12889-94 pubmed publisher
  9. Stuchell Brereton M, Skalicky J, Kieffer C, Karren M, Ghaffarian S, Sundquist W. ESCRT-III recognition by VPS4 ATPases. Nature. 2007;449:740-4 pubmed
    ..Thus, our studies reveal how the VPS4 ATPases recognize their CHMP substrates to facilitate the membrane fission events required for the release of viruses, endosomal vesicles and daughter cells. ..
  10. Weiss E, Gottlinger H. The role of cellular factors in promoting HIV budding. J Mol Biol. 2011;410:525-33 pubmed publisher
    ..Surprisingly, HIV-1 requires only a subset of ESCRT-III components, indicating that the membrane fission reaction that occurs during HIV-1 budding differs in crucial aspects from topologically related cellular abscission events. ..
  11. Prasad C, Melancon S, Rupar C, Prasad A, Nunez L, Rosenblatt D, et al. Exome sequencing reveals a homozygous mutation in TWINKLE as the cause of multisystemic failure including renal tubulopathy in three siblings. Mol Genet Metab. 2013;108:190-4 pubmed publisher
    ..Exome sequencing, revealed a homozygous novel mutation c.1183T>C (p.F395L) in exon 1 of the C10orf2 TWINKLE gene...
  12. Crespo Yanez X, Aguilar Gurrieri C, Jacomin A, Journet A, Mortier M, Taillebourg E, et al. CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis. PLoS Genet. 2018;14:e1007456 pubmed publisher
    ..Here, we show that the ESCRT-III member CHMP1B can be ubiquitinated within a flexible loop known to undergo conformational changes during polymerization...
  13. Bharti S, Sommers J, Zhou J, Kaplan D, Spelbrink J, Mergny J, et al. DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase. J Biol Chem. 2014;289:29975-93 pubmed publisher
    ..A biochemical analysis of purified recombinant human Twinkle protein (gene product of c10orf2) showed that the mitochondrial replicative helicase inefficiently unwinds well characterized intermolecular and ..
  14. Ma D, Liu Q, Zhang M, Feng J, Li X, Zhou Y, et al. iTRAQ-based quantitative proteomics analysis of the spleen reveals innate immunity and cell death pathways associated with heat stress in broilers (Gallus gallus). J Proteomics. 2019;196:11-21 pubmed publisher
    ..related to cell death were enriched in apoptosis (CTSD, PARP3 and IAP3), ferroptosis (FTH) and necroptosis (FTH, CHMP1B, TNFAIP3, PARP3 and IAP3)...
  15. Vild C, Li Y, Guo E, Liu Y, Xu Z. A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5. J Biol Chem. 2015;290:7291-303 pubmed publisher
    ..with the MIT (microtubule-interacting and transport)-interacting motifs of CHMP5 and a second ESCRT-III protein, CHMP1B, was determined at 1 Ã… resolution...
  16. Morino H, Pierce S, Matsuda Y, Walsh T, Ohsawa R, Newby M, et al. Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features. Neurology. 2014;83:2054-61 pubmed publisher
    ..In family 1, affected individuals were compound heterozygous for chromosome 10 open reading frame 2 (C10orf2) p.Arg391His and p.Asn585Ser. In family 2, affected individuals were compound heterozygous for C10orf2 p...
  17. Copeland W. Defects in mitochondrial DNA replication and human disease. Crit Rev Biochem Mol Biol. 2012;47:64-74 pubmed publisher
    ..This review focuses on our current knowledge of genetic defects of mtDNA replication (POLG, POLG2, C10orf2) and nucleotide metabolism (TYMP, TK2, DGOUK, and RRM2B) that cause instability of mtDNA and mitochondrial ..
  18. Remtulla S, Emilie Nguyen C, Prasad C, Campbell C. Twinkle-Associated Mitochondrial DNA Depletion. Pediatr Neurol. 2019;90:61-65 pubmed publisher
    Autosomal recessive mutations in the nuclear Twinkle (C10orf2) gene cause a mitochondrial DNA depletion syndrome (MDS) characterized by early onset hepatoencephalopathy...
  19. Luna B, Bhatia S, Yoo C, Felty Q, Sandberg D, Duchowny M, et al. Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. Mol Neurobiol. 2015;52:1341-1363 pubmed publisher
    ..fibrillary acidic protein isoform 2; phosphoserine aminotransferase isoform 1; Sirt2 histone deacetylase; and C10orf2 protein, mitochondrial DNA helicase...
  20. Ahmed S, Jelani M, Alrayes N, Mohamoud H, Almramhi M, Anshasi W, et al. Exome analysis identified a novel missense mutation in the CLPP gene in a consanguineous Saudi family expanding the clinical spectrum of Perrault Syndrome type-3. J Neurol Sci. 2015;353:149-54 pubmed publisher
    ..Mutations in five genes, HSD17B4, HARS2, CLPP, LARS2, and C10orf2, have been reported in five subtypes of PRLTS...
  21. Copeland W. Defects of mitochondrial DNA replication. J Child Neurol. 2014;29:1216-24 pubmed publisher
    ..This review focuses on our current knowledge of genetic defects of mitochondrial DNA replication (POLG, POLG2, C10orf2, and MGME1) that cause instability of mitochondrial DNA and mitochondrial disease.
  22. Spitzer C, Li F, Buono R, Roschzttardtz H, Chung T, Zhang M, et al. The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 2015;27:391-402 pubmed publisher
    ..Here, we show that the ESCRT-III subunit paralogs CHARGED MULTIVESICULAR BODY PROTEIN1 (CHMP1A) and CHMP1B are required for autophagic degradation of plastid proteins in Arabidopsis thaliana...
  23. Lindgren U, Roos S, Hedberg Oldfors C, Moslemi A, Lindberg C, Oldfors A. Mitochondrial pathology in inclusion body myositis. Neuromuscul Disord. 2015;25:281-8 pubmed publisher
    ..POLG was analyzed in all patients by Sanger sequencing and C10orf2 (Twinkle), DNA2, MGME1, OPA1, POLG2, RRM2B, SLC25A4 and TYMP in six patients by next generation sequencing...
  24. Horga A, Pitceathly R, Blake J, Woodward C, Zapater P, Fratter C, et al. Peripheral neuropathy predicts nuclear gene defect in patients with mitochondrial ophthalmoplegia. Brain. 2014;137:3200-12 pubmed publisher
    ..DNA deletion, 12 (10%) had a point mutation of mitochondrial DNA and 26 (22%) had mutations in either POLG, C10orf2 or RRM2B, or had multiple mitochondrial DNA deletions in muscle without an identified nuclear gene defect...
  25. Sanchez Martinez A, Calleja M, Peralta S, Matsushima Y, Hernández Sierra R, Whitworth A, et al. Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS ONE. 2012;7:e43954 pubmed publisher
    The human gene C10orf2 encodes the mitochondrial replicative DNA helicase Twinkle, mutations of which are responsible for a significant fraction of cases of autosomal dominant progressive external ophthalmoplegia (adPEO), a human ..
  26. Khan I, Crouch J, Bharti S, Sommers J, Carney S, Yakubovskaya E, et al. Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING. J Biol Chem. 2016;291:14324-39 pubmed publisher
    Mutations in the c10orf2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare genetic diseases characterized by mitochondrial defects...
  27. Zhang Y, Zhang J, Liu Z, Liu Y, Tuo S. A network-based approach to identify disease-associated gene modules through integrating DNA methylation and gene expression. Biochem Biophys Res Commun. 2015;465:437-42 pubmed publisher
    ..expression and methylation values of these genes between cases and controls, we find some genes, such as VASN, SNRPD3, and gene modules, targeted by POLR2C, CHMP1B and TAF9, which might be novel breast cancer-related biomarkers.
  28. Tzoulis C, Schwarzlmüller T, Biermann M, Haugarvoll K, Bindoff L. Mitochondrial DNA homeostasis is essential for nigrostriatal integrity. Mitochondrion. 2016;28:33-7 pubmed publisher
    ..mtDNA deletions, nuclear-encoded disorders of mtDNA replication and maintenance due to mutations in POLG or C10orf2 (Twinkle), and mutations in other nuclear mitochondrial genes including the mitochondrial aspartyl-tRNA ..
  29. Soldà G, Caccia S, Robusto M, Chiereghin C, Castorina P, Ambrosetti U, et al. First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family. J Hum Genet. 2016;61:295-300 pubmed publisher
    ..Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2 and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all cases of this ..
  30. Paramasivam A, Meena A, Pedaparthi L, Jyothi V, Uppin M, Jabeen S, et al. Novel mutation in C10orf2 associated with multiple mtDNA deletions, chronic progressive external ophthalmoplegia and premature aging. Mitochondrion. 2016;26:81-5 pubmed publisher
    ..12 unrelated patients with CPEO for mutation/multiple deletions in mtDNA and mutations in the coding regions of C10orf2, which is essential for mtDNA replication...
  31. Tafakhori A, Yu Jin Ng A, Tohari S, Venkatesh B, Lee H, Eskin A, et al. Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change. Arch Iran Med. 2016;19:87-91 pubmed publisher
    TWINKLE (c10orf2) gene is responsible for autosomal dominant progressive external ophthalmoplegia (PEO)...
  32. Bouchereau J, Barrot S, Dupre T, Moore S, Cardaş R, Capri Y, et al. Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants. JIMD Rep. 2016;29:109-113 pubmed
    The C10orf2 gene encodes Twinkle, a protein involved in mitochondrial DNA (mtDNA) replication...
  33. Yang H, Liu J, Lin J, Deng L, Fan S, Guo Y, et al. Overexpression of CHMP7 from rapeseed and Arabidopsis causes dwarfism and premature senescence in Arabidopsis. J Plant Physiol. 2016;204:16-26 pubmed publisher
    ..2 (CHMP4B), but also with VPS2.2 and CHMP1B. As expected, microarray analysis revealed that the expression of ESCRT transport genes is significantly affected...
  34. Wang M, An S, Wang D, Ji H, Geng M, Guo X, et al. Quantitative Proteomics Identify the Possible Tumor Suppressive Role of Protease-Activated Receptor-4 in Esophageal Squamous Cell Carcinoma Cells. Pathol Oncol Res. 2018;: pubmed publisher
    ..g. CHMP1B, PURA, PARG and HIST1H2AH)...
  35. Ołdak M, Oziębło D, Pollak A, Stepniak I, Lazniewski M, Lechowicz U, et al. Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome. J Transl Med. 2017;15:25 pubmed publisher
    ..Mutations in one of five different genes HSD17B4, HARS2, LARS2, CLPP or TWNK (previous symbol C10orf2) cause the autosomal recessive disorder but they are found only in about half of the patients...
  36. Demain L, Urquhart J, O SULLIVAN J, Williams S, Bhaskar S, Jenkinson E, et al. Expanding the genotypic spectrum of Perrault syndrome. Clin Genet. 2017;91:302-312 pubmed publisher
    ..Biallelic variants in five genes are reported to be causative: HSD17B4, HARS2, LARS2, CLPP and C10orf2. Here we present eight families affected by Perrault syndrome...
  37. Dursun F, Mohamoud H, Karim N, Naeem M, Jelani M, Kirmizibekmez H. A Novel Missense Mutation in the CLPP Gene Causing Perrault Syndrome Type 3 in a Turkish Family. J Clin Res Pediatr Endocrinol. 2016;8:472-477 pubmed publisher
    ..Mutations in five genes, i.e. HSD17B4, HARS2, CLPP, LARS2, and C10orf2, have been reported in five subtypes of PRLTS...
  38. Alkhateeb A, Aburahma S, Habbab W, Thompson I. Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability. Metab Brain Dis. 2016;31:901-7 pubmed publisher
    ..p.G410C in WWOX, p.H530Y in RARS2, and p.I69F in C10orf2 are novel changes that affect protein function and could give new insights into the development and function of ..
  39. Baumgärtel V, Muller B, Lamb D. Quantitative live-cell imaging of human immunodeficiency virus (HIV-1) assembly. Viruses. 2012;4:777-99 pubmed publisher
  40. Hadders M, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, et al. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. Proc Natl Acad Sci U S A. 2012;109:17424-9 pubmed publisher
    ..These results suggest a model whereby MITD1 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of cell division. ..
  41. Maemoto Y, Osako Y, Goto E, Nozawa E, Shibata H, Maki M. Calpain-7 binds to CHMP1B at its second ?-helical region and forms a ternary complex with IST1. J Biochem. 2011;150:411-21 pubmed publisher
    ..While two types of MIMs (MIM1 and MIM2) have been reported, CHMP1B has MIM1 and IST1 has both MIM1 and MIM2...
  42. Skalicky J, Arii J, Wenzel D, Stubblefield W, Katsuyama A, Uter N, et al. Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem. 2012;287:43910-26 pubmed publisher
    ..and show that the first microtubule-interacting and trafficking (MIT) module of the tandem LIP5 MIT domain binds CHMP1B (and other ESCRT-III proteins) through canonical type 1 MIT-interacting motif (MIM1) interactions...
  43. de Moor M, Liu Y, Boomsma D, Li J, Hamilton J, Hottenga J, et al. Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc. 2009;41:1887-95 pubmed publisher
    ..These can be detected by GWA as was shown here for the PAPSS2 gene, but larger samples with genome-wide genotypes and high-quality exercise data are needed for further progress. ..
  44. Solomons J, Sabin C, Poudevigne E, Usami Y, Hulsik D, Macheboeuf P, et al. Structural basis for ESCRT-III CHMP3 recruitment of AMSH. Structure. 2011;19:1149-59 pubmed publisher
    ..Our results indicate a tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III. ..
  45. Lee S, Chang J, Renvoisé B, Tipirneni A, Yang S, Blackstone C. MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Mol Biol Cell. 2012;23:4347-61 pubmed publisher
    ..ESCRT-III interactions of the MIT-domain family member MITD1 and identify strong interactions with charged multivesicular body protein 1B (CHMP1B), CHMP2A, and increased sodium tolerance-1 (IST1)...
  46. Cashikar A, Shim S, Roth R, Maldazys M, Heuser J, Hanson P. Structure of cellular ESCRT-III spirals and their relationship to HIV budding. elife. 2014;3: pubmed publisher
    ..Interpolating between the observed structures suggests a new role for Vps4 in separating ESCRT-III from Gag or other cargo to allow centripetal growth of a neck constricting ESCRT-III spiral...
  47. McNabb L, Moore K, Scena J, Buono R, Berrettini W. Association analysis of CHMP1.5 genetic variation and bipolar disorder. Psychiatr Genet. 2005;15:211-4 pubmed
    ..Variation in the CHMP1.5 gene does not appear to be associated with bipolar disorder. A systematic assessment of genetic variation in the region using association studies will be necessary. ..
  48. McCullough J, Clippinger A, Talledge N, Skowyra M, Saunders M, Naismith T, et al. Structure and membrane remodeling activity of ESCRT-III helical polymers. Science. 2015;350:1548-51 pubmed publisher
    ..a one-start, double-stranded helical copolymer composed of two different human ESCRT-III subunits, charged multivesicular body protein 1B (CHMP1B) and increased sodium tolerance 1 (IST1)...
  49. Bailey J, Fields A, Cheng K, Lee A, Wagenaar E, Lagrois R, et al. WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. J Biol Chem. 2015;290:8987-9001 pubmed publisher
    ..Taken together, these data suggest that WDR5 is specifically targeted to the midbody in the absence of chromatin and that it promotes abscission, perhaps by facilitating midbody microtubule disassembly. ..
  50. Stauffer D, Howard T, Nyun T, Hollenberg S. CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression. J Cell Sci. 2001;114:2383-93 pubmed
    ..In combination, these observations suggest that CHMP1 plays a role in stable gene silencing within the nucleus. ..
  51. Vuoristo J, Berrettini W, Ala Kokko L. C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11. Cytogenet Cell Genet. 2001;93:19-22 pubmed
    We have characterized a novel intronless human gene (C18orf2) which is embedded in intron 5 of the G-protein gene (GNAL) on chromosome 18p11. This gene codes for a 199 amino acid polypeptide with a predicted molecular weight of 22.1 kDa...
  52. Jouvenet N, Simon S, Bieniasz P. Visualizing HIV-1 assembly. J Mol Biol. 2011;410:501-11 pubmed publisher
    ..Overall, the particular advantages of individual particle imaging in living cells have yielded findings that would have been difficult or impossible to obtain using macroscopic or fixed-cell microscopic techniques. ..
  53. Jermy A. Virology: ESCRTing retroviruses to the exit. Nat Rev Microbiol. 2011;9:314 pubmed publisher
  54. Scott A, Gaspar J, Stuchell Brereton M, Alam S, Skalicky J, Sundquist W. Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc Natl Acad Sci U S A. 2005;102:13813-8 pubmed
    ..MIT) domain and demonstrate that the VPS4A MIT domain binds the C-terminal half of the ESCRT-III protein, CHMP1B (Kd = 20 +/- 13 microM)...
  55. Kuang Z, Seo E, Leis J. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. J Virol. 2011;85:7153-61 pubmed publisher
    ..CHMP5 is the primary switch to initiate the antiviral mechanism, because removal of CHMP5 from cells prevents ISGylation of CHMP2A and CHMP6. ..
  56. Kosaki R, Horikawa R, Fujii E, Kosaki K. Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms. Am J Med Genet A. 2018;176:404-408 pubmed publisher
    ..Causative genes include HARS2, HSD17B4, CLPP, C10orf2, and LARS2...