Gene Symbol: CHMP1A
Description: charged multivesicular body protein 1A
Alias: CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A, charged multivesicular body protein 1a, charged multivesicular body protein 1/chromatin modifying protein 1, chromatin modifying protein 1A, procollagen (type III) N-endopeptidase, protease, metallo, 1, 33kD, vacuolar protein sorting-associated protein 46-1
Species: human
Products:     CHMP1A

Top Publications

  1. Howard T, Stauffer D, Degnin C, Hollenberg S. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. J Cell Sci. 2001;114:2395-404 pubmed
    ..We have identified a conserved eukaryotic protein, human CHMP1, which is strongly implicated in multivesicular body formation...
  2. Li J, Belogortseva N, Porter D, Park M. Chmp1A functions as a novel tumor suppressor gene in human embryonic kidney and ductal pancreatic tumor cells. Cell Cycle. 2008;7:2886-93 pubmed
    Chmp1A (Chromatin modifying protein 1A/Charged multivesicular protein 1A) is a member of the ESCRT-III (Endosomal Sorting Complex Required for Transport) family that was shown to function in endosome-mediated trafficking via ..
  3. You Z, Xin Y, Liu Y, Sun J, Zhou G, Gao H, et al. Chmp1A acts as a tumor suppressor gene that inhibits proliferation of renal cell carcinoma. Cancer Lett. 2012;319:190-196 pubmed publisher
    Renal cell carcinoma (RCC) is a highly malignant and often fatal disease of the kidney. Chmp1A is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family, and plays a role in the cytoplasm in sorting proteins ..
  4. Stauffer D, Howard T, Nyun T, Hollenberg S. CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression. J Cell Sci. 2001;114:2383-93 pubmed
    ..Protein; CHarged Multivesicular body Protein), which is encoded by an alternative open reading frame in the PRSM1 gene and is conserved in both complex and simple eukaryotes...
  5. Stuchell Brereton M, Skalicky J, Kieffer C, Karren M, Ghaffarian S, Sundquist W. ESCRT-III recognition by VPS4 ATPases. Nature. 2007;449:740-4 pubmed
    ..Structures of VPS4A MIT-CHMP1A and VPS4B MIT-CHMP2B complexes reveal that the C-terminal CHMP motif forms an amphipathic helix that binds in a ..
  6. Solomons J, Sabin C, Poudevigne E, Usami Y, Hulsik D, Macheboeuf P, et al. Structural basis for ESCRT-III CHMP3 recruitment of AMSH. Structure. 2011;19:1149-59 pubmed publisher complex with AMSHΔC, revealing a novel MIT domain interacting motif (MIM) that does not overlap with the CHMP1-AMSH binding site. ITC and SPR measurements demonstrate an unusual high-affinity MIM-MIT interaction...
  7. Brune T, Kunze Schumacher H, Kölling R. Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae. Curr Genet. 2019;65:607-619 pubmed publisher
    ..Our analysis is in line with previous data pointing to a complex containing Did2/CHMP1 and Ist1/IST1...
  8. McCullough J, Fisher R, Whitby F, Sundquist W, Hill C. ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A. 2008;105:7687-91 pubmed publisher
    ..The homologous CHMP1-3 classes of ESCRT-III proteins also have C-terminal amphipathic helices, but, in those cases, the three ..
  9. Spitzer C, Li F, Buono R, Roschzttardtz H, Chung T, Zhang M, et al. The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 2015;27:391-402 pubmed publisher
    ..Here, we show that the ESCRT-III subunit paralogs CHARGED MULTIVESICULAR BODY PROTEIN1 (CHMP1A) and CHMP1B are required for autophagic degradation of plastid proteins in Arabidopsis thaliana...

More Information


  1. Coulter M, Dorobantu C, Lodewijk G, Delalande F, Cianférani S, Ganesh V, et al. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018;24:973-986.e8 pubmed publisher
    ..We recently showed human loss-of-function (LOF) mutations in ESCRT-III member CHMP1A cause autosomal recessive microcephaly with pontocerebellar hypoplasia, but its mechanism was unclear...
  2. Chassefeyre R, Martínez Hernández J, Bertaso F, Bouquier N, Blot B, Laporte M, et al. Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci. 2015;35:3155-73 pubmed publisher
    The charged multivesicular body proteins (Chmp1-7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helical polymers that change the curvature of cellular membrane domains...
  3. Jacomin A, Fauvarque M, Taillebourg E. A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila. BMC Cell Biol. 2016;17:36 pubmed
    ..either dsRNAs or dominant negative mutants targeting components of the endosomal machinery: Shibire, Rab4, Rab5, Chmp1 and Rab7...
  4. Park M, Upton D, Blackmon M, Dixon V, Craver S, Neal D, et al. Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway. BMC Complement Altern Med. 2018;18:71 pubmed publisher
    ..b>Chromatin Modifying Protein 1A (Chmp1A), Ataxia Telangiectasia Mutated (ATM), and p53 were the primary signaling molecules examined...
  5. Rollinson S, Young K, Bennion Callister J, Pickering Brown S. Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis. Eur J Neurosci. 2016;44:2214-25 pubmed publisher
    ..spliceosome and proteasome in response to PGRN treatment, as well as the lysosomal pathway constituents such as CHMP1A, further supporting the role of PGRN in lysosomal function...
  6. Bartusch C, Prange R. ESCRT Requirements for Murine Leukemia Virus Release. Viruses. 2016;8:103 pubmed publisher
    ..In case of CHMP1, we unexpectedly observed that the CHMP1A isoform was specifically required for virus budding, but dispensable for VLP release...
  7. Buono R, Paez Valencia J, Miller N, Goodman K, Spitzer C, Spalding E, et al. Role of SKD1 Regulators LIP5 and IST1-LIKE1 in Endosomal Sorting and Plant Development. Plant Physiol. 2016;171:251-64 pubmed publisher
    ..the ISTL1-6 group, ISTL1 showed the strongest interaction with LIP5, SKD1, and the ESCRT-III-related proteins CHMP1A in yeast two hybrid assays...
  8. Martin Serrano J, Yarovoy A, Perez Caballero D, Bieniasz P, Yaravoy A. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:12414-9 pubmed
  9. von Schwedler U, Stuchell M, Muller B, Ward D, Chung H, Morita E, et al. The protein network of HIV budding. Cell. 2003;114:701-13 pubmed
    ..These studies define a protein network required for human MVB biogenesis and indicate that the entire network participates in the release of HIV and probably many other viruses. ..
  10. Agromayor M, Carlton J, Phelan J, Matthews D, Carlin L, Ameer Beg S, et al. Essential role of hIST1 in cytokinesis. Mol Biol Cell. 2009;20:1374-87 pubmed publisher
    ..KIAA0174 as the human homologue of IST1 (hIST1), and we report its conserved interaction with VPS4, CHMP1A/B, and LIP5...
  11. Tandon R, AuCoin D, Mocarski E. Human cytomegalovirus exploits ESCRT machinery in the process of virion maturation. J Virol. 2009;83:10797-807 pubmed publisher
    ..Both Vps4A and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in ..
  12. Manohar S, Harlow M, Nguyen H, Li J, Hankins G, Park M. Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition. Cell Cycle. 2011;10:2529-39 pubmed
    b>Chromatin modifying protein 1A (Chmp1A) is a member of the Endosormal sorting complex required for transport (ESCRT)-III family whose over-expression induces growth inhibition, chromatin condensation, and p53 phosphorylation...
  13. Scott I, Halila R, Jenkins J, Mehan S, Apostolou S, Winqvist R, et al. Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1). Gene. 1996;174:135-43 pubmed
    ..We have named this novel protein PRSM1 (PRoteaSe, Metallo, number 1)...
  14. Yoshida H, Haze K, Yanagi H, Yura T, Mori K. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem. 1998;273:33741-9 pubmed
    ..These results suggest that, as in yeast, bZIP proteins are involved in mammalian UPR, acting through newly defined ERSE. ..
  15. Hadders M, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, et al. ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes. Proc Natl Acad Sci U S A. 2012;109:17424-9 pubmed publisher
    ..These results suggest a model whereby MITD1 coordinates the activity of ESCRT-III during abscission with earlier events in the final stages of cell division. ..
  16. Mochida G, Ganesh V, de Michelena M, Dias H, Atabay K, Kathrein K, et al. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012;44:1260-4 pubmed publisher
    b>Charged multivesicular body protein 1A (CHMP1A; also known as chromatin-modifying protein 1A) is a member of the ESCRT-III (endosomal sorting complex required for transport-III) complex but is also suggested to localize to the nuclear ..
  17. Bajorek M, Morita E, Skalicky J, Morham S, Babst M, Sundquist W. Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell. 2009;20:1360-73 pubmed publisher
    ..IST1 binding interactions with VPS4, CHMP1, LIP5, and ESCRT-I were characterized, and the IST1-VPS4 interaction was investigated in detail...
  18. Tong W, Nagano Fujii M, Hidajat R, Deng L, Takigawa Y, Hotta H. Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta. Biochem Biophys Res Commun. 2002;299:366-72 pubmed
    ..Collectively, our results imply the possibility that NS4B modulates certain cellular responses upon ER stress through the physical interaction with CREB-RP/ATF6beta and ATF6alpha...
  19. Fang W, Wei Y, Kang Y, Landweber L. Detection of a common chimeric transcript between human chromosomes 7 and 16. Biol Direct. 2012;7:49 pubmed publisher
    ..Here we report the computational detection of an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A from RNA-seq data of normal human mammary epithelial cells, and experimental confirmation of the chimeric ..
  20. Hao Y, Liu X, Lu X, Yang X, Wang L, Chen S, et al. Genome-wide association study in Han Chinese identifies three novel loci for human height. Hum Genet. 2013;132:681-9 pubmed publisher
    ..80 × 10(-10)). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height. ..
  21. Maemoto Y, Shibata H, Maki M. Identification of phosphorylation sites in the C-terminal region of charged multivesicular body protein 1A (CHMP1A). Biosci Biotechnol Biochem. 2013;77:1317-9 pubmed
    Human charged multivesicular body protein 1A (CHMP1A) displayed two bands on SDS-PAGE and differences in efficiency of complex formation with IST1...
  22. Morita E, Colf L, Karren M, Sandrin V, Rodesch C, Sundquist W. Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A. 2010;107:12889-94 pubmed publisher
  23. Rigden D, Liu H, Hayes S, Urbé S, Clague M. Ab initio protein modelling reveals novel human MIT domains. FEBS Lett. 2009;583:872-8 pubmed publisher
    ..As a proof of principle, we have confirmed the novel MIT annotation for USP54 by in vitro profiling of binding to CHMP proteins. ..
  24. Row P, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem. 2007;282:30929-37 pubmed
    ..CHMP family between the UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY ..
  25. Agromayor M, Martin Serrano J. Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo. J Biol Chem. 2006;281:23083-91 pubmed
    ..endosomal deubiquitinating enzyme, with the endodomal sorting complex required for transport (ESCRT-III) subunits CHMP1A, CHMP1B, CHMP2A, and CHMP3...
  26. Strack B, Calistri A, Craig S, Popova E, Gottlinger H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003;114:689-99 pubmed
    ..These observations identify AIP1 as a component of the viral budding machinery, which serves to link a distinct region in the L domain of HIV-1 p6 and EIAV p9 to ESCRT-III...