CFL1

Summary

Gene Symbol: CFL1
Description: cofilin 1
Alias: CFL, HEL-S-15, cofilin, cofilin-1, 18 kDa phosphoprotein, cofilin 1 (non-muscle), cofilin, non-muscle isoform, epididymis secretory protein Li 15, p18
Species: human
Products:     CFL1

Top Publications

  1. Gohla A, Bokoch G. 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin. Curr Biol. 2002;12:1704-10 pubmed
    ..Proteins of the ADF/cofilin family are essential for the high rates of actin filament turnover observed in motile cells through regulation of ..
  2. Yan H, Yang K, Xiao H, Zou Y, Zhang W, Liu H. Over-expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance. CNS Neurosci Ther. 2012;18:729-36 pubmed publisher
    ..A total of 36 proteins were expressed differently between the 2 groups, represented by cofilin-1 and phosphoglycerate kinase 1 (PGK1), which up-regulated significantly in radioresistant astrocytomas though ..
  3. Fazal F, Bijli K, Minhajuddin M, Rein T, Finkelstein J, Rahman A. Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. J Biol Chem. 2009;284:21047-56 pubmed publisher
    ..Here, we show a central role of cofilin-1, an actin-binding protein that promotes actin depolymerization, in linking RhoA/ROCK pathway to dynamic ..
  4. Xiang Y, Zheng K, Ju H, Wang S, Pei Y, Ding W, et al. Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication. J Virol. 2012;86:8440-51 pubmed publisher
    ..The active form of the actin-depolymerizing factor cofilin 1 was found to increase at an early stage of infection and then to continuously decrease in a manner that ..
  5. Jimenez Baranda S, Gomez Mouton C, Rojas A, Martinez Prats L, Mira E, Ana Lacalle R, et al. Filamin-A regulates actin-dependent clustering of HIV receptors. Nat Cell Biol. 2007;9:838-46 pubmed
    ..We found that gp120 binding to cell receptors induces transient cofilin-phosphorylation inactivation through a RhoA-ROCK-dependent mechanism...
  6. Stolp B, Reichman Fried M, Abraham L, Pan X, Giese S, Hannemann S, et al. HIV-1 Nef interferes with host cell motility by deregulation of Cofilin. Cell Host Microbe. 2009;6:174-86 pubmed publisher
    ..Nef strongly induces phosphorylation of cofilin, inactivating this evolutionarily conserved actin-depolymerizing factor that promotes cell motility when ..
  7. Klamt F, Zdanov S, Levine R, Pariser A, Zhang Y, Zhang B, et al. Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin. Nat Cell Biol. 2009;11:1241-6 pubmed publisher
    ..We found that the actin-binding protein cofilin is a key target of oxidation...
  8. Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher
    ..Mechanistic analysis revealed that this interaction results in deregulation of the actin-severing factor cofilin and thus blocks the chemokine-mediated actin remodeling required for cell motility...
  9. Birkenfeld J, Betz H, Roth D. Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta. Biochem J. 2003;369:45-54 pubmed
    ..Here we show that the 14-3-3 zeta isoform interacts with both the actin-depolymerizing factor cofilin and its regulatory kinase, LIM (Lin-11/Isl-1/Mec-3)-domain-containing protein kinase 1 (LIMK1)...

More Information

Publications93

  1. Toshima J, Toshima J, Takeuchi K, Mori R, Mizuno K. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001;276:31449-58 pubmed
    We previously identified testicular protein kinase 1 (TESK1), which phosphorylates cofilin and induces actin cytoskeletal reorganization...
  2. Toshima J, Toshima J, Amano T, Yang N, Narumiya S, Mizuno K. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell. 2001;12:1131-45 pubmed
    ..Like LIM-kinases, TESK1 phosphorylated cofilin specifically at Ser-3, both in vitro and in vivo...
  3. Ono S, Minami N, Abe H, Obinata T. Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle. J Biol Chem. 1994;269:15280-6 pubmed
    b>Cofilin is an actin-modulating protein of 20 kDa, which is widely distributed throughout muscle and non-muscle cells...
  4. von Blume J, Alleaume A, Cantero Recasens G, Curwin A, Carreras Sureda A, Zimmermann T, et al. ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1. Dev Cell. 2011;20:652-62 pubmed publisher
    Actin-severing proteins ADF/cofilin are required for the sorting of secretory cargo at the trans-Golgi network (TGN) in mammalian cells...
  5. Nebl G, Meuer S, Samstag Y. Dephosphorylation of serine 3 regulates nuclear translocation of cofilin. J Biol Chem. 1996;271:26276-80 pubmed
    Signal transduction processes in T-cells and other cell types alter the phosphorylation state of cofilin, an actin-binding phosphoprotein...
  6. Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, et al. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature. 1998;393:809-12 pubmed
    ..Little is known about the signalling pathways that link Rac activation to changes in actin filament dynamics. Cofilin is known to be a potent regulator of actin filament dynamics, and its ability to bind and depolymerize actin is ..
  7. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 1999;285:895-8 pubmed
    ..b>Cofilin exhibits actin-depolymerizing activity that is inhibited as a result of its phosphorylation by LIM-kinase...
  8. Lee K, Jung J, Kim M, Guidotti G. Interaction of the alpha subunit of Na,K-ATPase with cofilin. Biochem J. 2001;353:377-85 pubmed
    ..Several cDNA clones were isolated, some of which coded for cofilin, an actin-binding protein...
  9. Xu Y, Wang D. [Relationship between cofilin-1 expression and implantation capacity in eutopic endometrium of patient with endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2010;45:252-5 pubmed
    To investigate the relationship between expression of cofilin-1 and in vivo implantation capacity of eutopic endometrium of endometriosis...
  10. Wang Y, Kuramitsu Y, Ueno T, Suzuki N, Yoshino S, Iizuka N, et al. Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues. Oncol Rep. 2011;26:1595-9 pubmed publisher
    ..showed stronger intensity in cancerous compared to non-cancerous tissues was identified as non-muscle cofilin (cofilin-1). This up-regulation was validated by Western blot analysis...
  11. Gillett G, Fox M, Rowe P, Casimir C, Povey S. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. Ann Hum Genet. 1996;60:201-11 pubmed
    b>Cofilin is a widely-distributed, intracellular, actin binding protein which is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus...
  12. Zhang Y, Tong X. Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size. J Int Med Res. 2010;38:1042-8 pubmed
    This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of ..
  13. Bukrinsky M. How to engage Cofilin. Retrovirology. 2008;5:85 pubmed publisher
    ..the viral gp120 and cellular HIV co-receptor, CXCR4, during viral entry initiates signaling that activates cofilin, the main regulator of actin polymerization...
  14. Yoder A, Yu D, Dong L, Iyer S, Xu X, Kelly J, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008;134:782-92 pubmed publisher
    ..signaling from the chemokine coreceptor CXCR4 to activate a cellular actin-depolymerizing factor, cofilin, to overcome this restriction...
  15. Estornes Y, Gay F, Gevrey J, Navoizat S, Nejjari M, Scoazec J, et al. Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. Int J Cancer. 2007;121:2162-71 pubmed
    Actin depolymerizing factor (ADF)/cofilin family proteins are key regulators of actin filament turnover and cytoskeleton reorganization...
  16. Niwa R, Nagata Ohashi K, Takeichi M, Mizuno K, Uemura T. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell. 2002;108:233-46 pubmed
    The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of actin dynamics...
  17. Peterburs P, Heering J, Link G, Pfizenmaier K, Olayioye M, Hausser A. Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like. Cancer Res. 2009;69:5634-8 pubmed publisher
    ..In this study, we provide evidence that the cofilin phosphatase slingshot 1 like (SSH1L), an important regulator of the complex actin remodeling machinery, is a ..
  18. Amano T, Kaji N, Ohashi K, Mizuno K. Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis. J Biol Chem. 2002;277:22093-102 pubmed
    ..LIM motif-containing protein kinase 1 (LIMK1) regulates actin reorganization by phosphorylating and inactivating cofilin, an actin-depolymerizing and -severing protein...
  19. Rüegg J, Holsboer F, Turck C, Rein T. Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells. Mol Cell Biol. 2004;24:9371-82 pubmed
    ..An unexpected candidate, cofilin 1, inhibited receptor activity. Cofilin is known to promote actin depolymerization and filament severing...
  20. Garg P, Verma R, Cook L, Soofi A, Venkatareddy M, George B, et al. Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. J Biol Chem. 2010;285:22676-88 pubmed publisher
    ..junction receptor Nephrin plays a role in regulating actin dynamics, and given the described role of cofilin in actin filament polymerization and severing, we hypothesized that cofilin-1 activity is regulated by Nephrin ..
  21. Castro M, Dal Pizzol F, Zdanov S, Soares M, Muller C, Lopes F, et al. CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer. Cancer. 2010;116:3645-55 pubmed publisher
    ..metastasis, and this behavior requires great cell motility, herein the authors assessed the potential value of CFL1 gene (main member of the invasion/metastasis pathway) as a prognostic and predictive NSCLC biomarker...
  22. Pope B, Zierler Gould K, Kühne R, Weeds A, Ball L. Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. J Biol Chem. 2004;279:4840-8 pubmed
    Human actin-depolymerizing factor (ADF) and cofilin are pH-sensitive, actin-depolymerizing proteins. Although 72% identical in sequence, ADF has a much higher depolymerizing activity than cofilin at pH 8...
  23. Katafigioti A, Katafigiotis I, Sfoungaristos S, Alamanis C, Stravodimos K, Anastasiou I, et al. In the search of novel urine biomarkers for the early diagnosis of prostate cancer. Intracellular or secreted proteins as the target group? Where and how to search for possible biomarkers useful in the everyday clinical practice. Arch Ital Urol Androl. 2016;88:195-200 pubmed publisher
    ..in the urine samples with Western-blot, as possible biomarkers, were Glutathione peroxidase 3 precursor (GPx3), Cofilin-1 (CFL1), Heat shock protein-90? (HSP 90?), Zinc alpha 2-glycoprotein (ZAG) and secreted protein acidic and rich ..
  24. Abe H, Nagaoka R, Obinata T. Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes. Exp Cell Res. 1993;206:1-10 pubmed
    We used immunofluorescence methods to examine the cellular distribution of cofilin in chicken myotubes in primary culture...
  25. Orejarena Pacheco J, Lipp A, Nauth A, Acke F, Dietz J, Opatz T. A Highly Active System for the Metal-Free Aerobic Photocyanation of Tertiary Amines with Visible Light: Application to the Synthesis of Tetraponerines and Crispine A. Chemistry. 2016;22:5409-15 pubmed publisher
    ..as terminal oxidant offers an improved safety profile compared with pure oxygen, the used compact fluorescent lamp (CFL) light sources are highly economical, and no halogenated solvents are required...
  26. Zhou T, Wang C, Yan H, Zhang R, Zhao J, Qian C, et al. Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells. Mol Med Rep. 2016;13:4414-20 pubmed publisher
    ..b>Cofilin?1 (CFL?1), which is regulated by the Rac1?WAVE2?Arp2/3 signaling pathway, may promote radioresistance in glioma...
  27. Michels F, Cordier G, Guillo S, Stockmans F. Endoscopic Ankle Lateral Ligament Graft Anatomic Reconstruction. Foot Ankle Clin. 2016;21:665-80 pubmed publisher
    ..This article describes an endoscopic technique, using a step-by-step approach, to reconstruct the ATFL and CFL with a gracilis graft...
  28. Elam W, Kang H, De La Cruz E. Biophysics of actin filament severing by cofilin. FEBS Lett. 2013;587:1215-9 pubmed publisher
    ..b>Cofilin induces net structural changes in filaments that render them more compliant in bending and twisting...
  29. Becker M, De Bastiani M, Muller C, Markoski M, Castro M, Klamt F. High cofilin-1 levels correlate with cisplatin resistance in lung adenocarcinomas. Tumour Biol. 2014;35:1233-8 pubmed publisher
    High cofilin-1 levels have been shown to be an accurate prognostic biomarker in non-small cell lung cancer (NSCLC) and a predictive factor in drug resistance...
  30. Xu X, Gera N, Li H, Yun M, Zhang L, Wang Y, et al. GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis. Mol Biol Cell. 2015;26:874-86 pubmed publisher
    ..reveal a novel signaling pathway, including Gαi, PLC, PKCβ, protein kinase D (PKD), and SSH2, in control of cofilin phosphorylation and actin cytoskeletal reorganization, which is essential for neutrophil chemotaxis...
  31. Chen L, Shi K, Frary C, Ditzel N, Hu H, Qiu W, et al. Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells. Stem Cell Res. 2015;15:281-9 pubmed publisher
    ..stabilizing actin filaments by inhibiting gene expression of the two main actin depolymerizing factors (ADFs): Cofilin 1 (CFL1) and Destrin (DSTN) in hMSCs, enhanced cell viability and differentiation into osteoblastic cells (OB) in ..
  32. Grzanka D, Kowalczyk A, Izdebska M, Klimaszewska Wisniewska A, Gagat M. The interactions between SATB1 and F-actin are important for mechanisms of active cell death. Folia Histochem Cytobiol. 2015;53:152-61 pubmed publisher
    ..The amount and localization of F-actin were altered by changes of cofilin-1 (CFL1) expression in MCF-7 cells...
  33. Liu Z, Chu S, Yao S, Li Y, Fan S, Sun X, et al. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. Oncotarget. 2016;7:68303-68313 pubmed publisher
    ..Moreover, CD74 overexpression promoted the phosphorylation of the actin-severing protein cofilin (CFL1), resulting in actin polymerization in breast cancer cells...
  34. Sumi T, Matsumoto K, Shibuya A, Nakamura T. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J Biol Chem. 2001;276:23092-6 pubmed
    LIM kinases (LIMK1 and LIMK2) regulate actin cytoskeletal reorganization through cofilin phosphorylation downstream of distinct Rho family GTPases...
  35. Wang F, Wu D, He F, Fu H, Xu J, Chen J, et al. Study on the significance of Cofilin 1 overexpression in human bladder cancer. Tumori. 2016;: pubmed publisher
    b>Cofilin 1 is a type of cytoskeletal protein. The overexpression of this gene has been regarded to hold a special relationship with the development and progress of some cancers...
  36. Jansen S, Collins A, Chin S, Ydenberg C, Gelles J, Goode B. Single-molecule imaging of a three-component ordered actin disassembly mechanism. Nat Commun. 2015;6:7202 pubmed publisher
    ..cells destabilize and rapidly disassemble filamentous actin networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated in this process...
  37. Nishimura S, Tsuda H, Kataoka F, Arao T, Nomura H, Chiyoda T, et al. Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy. Hum Pathol. 2011;42:516-21 pubmed publisher
    The aim of this study was to examine the relation between cofilin 1 expression and progression-free survival in advanced epithelial ovarian cancer...
  38. Zierler Gould K, Pope B, Weeds A, Ball L. Backbone and sidechain 1H, 13C and 15N resonance assignments of human cofilin. J Biomol NMR. 2004;29:429-30 pubmed
  39. Zoudilova M, Kumar P, Ge L, Wang P, Bokoch G, DeFea K. Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem. 2007;282:20634-46 pubmed
    ..PAR-2 promotes beta-arrestin-dependent dephosphorylation and activation of the actin filament-severing protein (cofilin) independently of Galpha(q)/Ca(2+) signaling...
  40. Pinho D, Campo Deaño L, Lima R, Pinho F. In vitro particulate analogue fluids for experimental studies of rheological and hemorheological behavior of glucose-rich RBC suspensions. Biomicrofluidics. 2017;11:054105 pubmed publisher
    ..In addition, the well-known cell-free layer (CFL) phenomenon occurring in microchannels was investigated in detail to provide comparisons between healthy and ..
  41. Bijelic Donova J, Garoushi S, Vallittu P, Lassila L. Mechanical properties, fracture resistance, and fatigue limits of short fiber reinforced dental composite resin. J Prosthet Dent. 2016;115:95-102 pubmed publisher
    ..The purpose of this study was to determine the fracture resistance and the compressive fatigue limits (CFL) of anterior crown restorations made of a short-fiber reinforced composite resin (SFC), to investigate selected ..
  42. Lee B, Choi K, Seo D, Choi S, Kim G. Diagnostic validity of alternative manual stress radiographic technique detecting subtalar instability with concomitant ankle instability. Knee Surg Sports Traumatol Arthrosc. 2016;24:1029-39 pubmed publisher
    ..Sixty-six patients with combined injuries of the anterior talofibular (ATFL) and calcaneofibular ligament (CFL) underwent three bilateral manual stress radiographs, and mean increments of anterior talar translation (mm), talar ..
  43. Pahari S, Pal P, Srivastava D, Ghosh S, Panda A. Efficient photocatalytic selective nitro-reduction and C-H bond oxidation over ultrathin sheet mediated CdS flowers. Chem Commun (Camb). 2015;51:10322-5 pubmed publisher
    ..8 nm) sheet mediated uniform CdS flowers as catalyst under a household 40 W CFL lamp and molecular oxygen as oxidant...
  44. Yao J, Hennessey T, Flynt A, Lai E, Beal M, Lin M. MicroRNA-related cofilin abnormality in Alzheimer's disease. PLoS ONE. 2010;5:e15546 pubmed publisher
    Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients...
  45. Ren X, Yang X, Hong W, Huang P, Wang Y, Liu W, et al. Identification of the proteins related to SET-mediated hepatic cytotoxicity of trichloroethylene by proteomic analysis. Toxicol Lett. 2014;227:12-9 pubmed publisher
    ..proteins identified, 8 were found to be modulated by SET in TCE-induced cytotoxicity and three of them (cofilin-1, peroxiredoxin-2 and S100-A11) were validated by Western-blot analysis...
  46. Foletta V, Lim M, Soosairajah J, Kelly A, Stanley E, Shannon M, et al. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol. 2003;162:1089-98 pubmed
    ..LIM kinase (LIMK) 1 is a key regulator of actin dynamics as it phosphorylates and inactivates cofilin, an actin depolymerizing factor...
  47. Tsai C, Chiu S, Liu C, Sheu T, Hsieh C, Keng P, et al. Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. Cell Cycle. 2009;8:2365-74 pubmed
    b>Cofilin, a ubiquitously expressed actin binding protein, is responsible for the formation of the actin cytoskeleton and is indispensable for cell cycle control...
  48. Kim T, Vidal G, Djurisic M, William C, Birnbaum M, Garcia K, et al. Human LilrB2 is a ?-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science. 2013;341:1399-404 pubmed publisher
    ..two extracellular immunoglobulin (Ig) domains of PirB and LilrB2 mediate this interaction, leading to enhanced cofilin signaling, also seen in human AD brains...
  49. Ngo K, Kodera N, Katayama E, Ando T, Uyeda T. Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy. elife. 2015;4: pubmed publisher
    High-speed atomic force microscopy was employed to observe structural changes in actin filaments induced by cofilin binding...
  50. Zhao J, Gao Z, Ji Q, Wang H, Zhang H, Yang Y, et al. Regulation of cofilin activity by CaMKII and calcineurin. Am J Med Sci. 2012;344:462-72 pubmed publisher
    b>Cofilin promotes actin filament turnover by severing and depolymerizing actin filaments...
  51. Sha Y, Wang H, Ding J, Tang H, Li C, Luo H, et al. A novel patient-specific navigational template for anatomical reconstruction of the lateral ankle ligaments. Int Orthop. 2016;40:59-64 pubmed publisher
    ..American Orthopaedic Foot and Ankle Society (AOFAS) scores for patients in the calcaneofibular ligament (CFL) plus anterior talofibular ligament (ATFL) repair group were 48.3 ± 5.1 and 88...
  52. Nagumo Y, Han J, Bellila A, Isoda H, Tanaka T. Cofilin mediates tight-junction opening by redistributing actin and tight-junction proteins. Biochem Biophys Res Commun. 2008;377:921-5 pubmed publisher
    We previously found that capsaicin induces tight-junction (TJ) opening accompanied with cofilin dephosphorylation/activation in intestinal Caco-2 cells...
  53. Ashworth S, Teng B, Kaufeld J, Miller E, Tossidou I, Englert C, et al. Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans. PLoS ONE. 2010;5:e12626 pubmed publisher
    ..Since the actin binding protein, cofilin-1, plays a significant role in the regulation of actin dynamics, we examined its role in podocytes to determine ..
  54. Wang Y, Shibasaki F, Mizuno K. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J Biol Chem. 2005;280:12683-9 pubmed
    b>Cofilin, an essential regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 and reactivated by dephosphorylation...
  55. Huang L, Kuwahara I, Matsumoto K. EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA. Oncogene. 2014;33:2995-3003 pubmed publisher
    ..EWS binds to the 3'-untranslated region in another mRNA target, cofilin 1 (CFL1), and negatively regulates the expression of CFL1...
  56. Shaheed S, Rustogi N, Scally A, Wilson J, Thygesen H, Loizidou M, et al. Identification of stage-specific breast markers using quantitative proteomics. J Proteome Res. 2013;12:5696-708 pubmed publisher
    ..Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in invasive carcinoma),..
  57. Vitolo M, Boggs A, Whipple R, Yoon J, Thompson K, Matrone M, et al. Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin. Oncogene. 2013;32:2200-10 pubmed publisher
    ..One such actin-severing protein, cofilin, is activated in detached PTEN(-/-) cells that could weaken the actin cortex to promote McTNs...
  58. Ishaq M, Lin B, Bosche M, Zheng X, Yang J, Huang D, et al. LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes. BMC Mol Biol. 2011;12:41 pubmed publisher
    ..Overexpression or siRNA-induced knockdown of cofilin-1 (CFL1), a key regulator of F-actin assembly, induced the loss of receptor function...
  59. Sudnitsyna M, Seit Nebi A, Gusev N. Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20). Arch Biochem Biophys. 2012;521:62-70 pubmed publisher
    It has been previously reported that phosphorylated cofilin interacted with 14-3-3? protein to generate a sub-micromolar K(d) binary complex...
  60. Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, et al. Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration. J Cell Sci. 2009;122:787-97 pubmed publisher
    ..Using the yeast two-hybrid approach to gain insight into Memo function, an interaction between Memo and cofilin, a regulator of actin dynamics, was uncovered...
  61. Li M, Yin J, Mao N, Pan L. Upregulation of phosphorylated cofilin 1 correlates with taxol resistance in human ovarian cancer in vitro and in vivo. Oncol Rep. 2013;29:58-66 pubmed publisher
    ..In this study, we demonstrated that the protein, phosphorylated cofilin 1 (p-CFL1) correlates with taxol resistance in human ovarian cancer cells...
  62. Tsai C, Lin L, Wang C, Chiu Y, Chou Y, Chiu S, et al. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. Biochim Biophys Acta. 2015;1852:851-61 pubmed publisher
    b>Cofilin-1, a non-muscle isoform of actin regulatory protein that belongs to the actin-depolymerizing factor (ADF)/cofilin family is known to affect cancer development...
  63. Tabur S, Oztuzcu S, Oguz E, Demiryürek S, Dağlı H, Alasehirli B, et al. Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome. Endocrine. 2016;53:465-70 pubmed publisher
    ..96 dynamic array system. We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in MetS patients...
  64. Chin S, Jansen S, Goode B. TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover. J Mol Biol. 2016;428:1604-16 pubmed publisher
    ..and turnover of cellular actin networks requires actin filament severing by actin-depolymerizing factor (ADF)/Cofilin proteins...
  65. Sheng N, Tan G, You W, Chen H, Gong J, Chen D, et al. MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway. Cancer Med. 2017;6:1331-1340 pubmed publisher
    ..invasion ability of SW1116 cells was affected through the down-regulation of phosphorylation level of LIMK1 and cofilin in a PAK4-dependent manner...
  66. Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T. Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. Biochem Biophys Res Commun. 2004;314:396-402 pubmed
    ..We showed here that Hsp105alpha interacted with several cellular proteins, such as cofilin, dynein light chain 2A, alpha-adducin, ubiquitin activating enzyme E1, phosphoglycerate kinase 1, and platelet-..
  67. Yeoh S, Pope B, Mannherz H, Weeds A. Determining the differences in actin binding by human ADF and cofilin. J Mol Biol. 2002;315:911-25 pubmed
    The actin-depolymerizing factor (ADF)/cofilin family of proteins play an essential role in actin dynamics and cytoskeletal re-organization...
  68. Ott D, Coren L, Kane B, Busch L, Johnson D, Sowder R, et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol. 1996;70:7734-43 pubmed
    ..relative to the molar level of Gag: actin (approximately 10 to 15%), ezrin and moesin (approximately 2%), and cofilin (approximately 2 to 10%)...
  69. Lederer F, Curtis S, Bachmann S, Dunbar W, MacGillivray R. Identification of lanthanum-specific peptides for future recycling of rare earth elements from compact fluorescent lamps. Biotechnol Bioeng. 2017;114:1016-1024 pubmed publisher
    ..phosphate doped with cerium and terbium as part of the fluorescent phosphors of spent compact fluorescent lamps (CFL) was used as a target material of economic interest to test the suitability of the phage display method to the ..
  70. Shanidze N, Heinen S, Verghese P. Monocular and binocular smooth pursuit in central field loss. Vision Res. 2017;141:181-190 pubmed publisher
    Macular degeneration results in heterogeneous central field loss (CFL) and often has asymmetrical effects in the two eyes. As such, it is not clear to what degree the movements of the two eyes are coordinated...
  71. Piña Medina A, Hansberg Pastor V, González Arenas A, Cerbón M, Camacho Arroyo I. Progesterone promotes cell migration, invasion and cofilin activation in human astrocytoma cells. Steroids. 2016;105:19-25 pubmed publisher
    ..to deregulation of cell motility-dependent cytoskeletal dynamics that involves actin-binding proteins such as cofilin. Progesterone (P4) has been found to induce migration and invasion of cells derived from breast cancer and ..
  72. Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, et al. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J. 2005;24:473-86 pubmed
    ..dynamics via a reversible phosphorylation (inactivation) of serine 3 in actin-depolymerizing factor (ADF) and cofilin. Here we demonstrate that a multi-protein complex consisting of SSH-1L, LIMK1, actin, and the scaffolding protein,..
  73. Koga R, Sugita Y, Noda T, Yanagi Y, Ohno S. Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region. J Virol. 2015;89:10524-31 pubmed publisher
    ..In this report, we show that cofilin, an actin-modulating host protein, interacts with the MV N protein and aids in the formation of the RNP complex...
  74. Lee Y, Sheu T, Keng P. Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin. Biochem Biophys Res Commun. 2005;335:286-91 pubmed
    b>Cofilin is an actin-associated protein that belongs to the actin depolymerization factor/cofilin family and is important for regulation of actin dynamics...
  75. Zhang H, Lechuga T, Tith T, Wang W, Wing D, Chen D. S-nitrosylation of cofilin-1 mediates estradiol-17β-stimulated endothelial cytoskeleton remodeling. Mol Endocrinol. 2015;29:434-44 pubmed publisher
    ..b>Cofilin-1 (CFL1) is a small actin-binding protein essential for actin dynamics and cytoskeleton remodeling...
  76. Zhang H, Wang W, Feng L, Yang Y, Zheng J, Huang L, et al. S-nitrosylation of Cofilin-1 Serves as a Novel Pathway for VEGF-Stimulated Endothelial Cell Migration. J Cell Physiol. 2015;230:406-17 pubmed publisher
    ..The small actin-binding protein cofilin-1 (CFL1) is essential for actin cytoskeleton remodeling...
  77. Palavicini J, Wang H, Minond D, Bianchi E, Xu S, Lakshmana M. RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain. J Alzheimers Dis. 2014;39:727-40 pubmed publisher
    ..Most importantly, AP?E9/RanBP9 mice also showed significantly reduced levels of the phosphorylated form of cofilin in the hippocampus...
  78. Klejnot M, Gabrielsen M, Cameron J, Mleczak A, Talapatra S, Kozielski F, et al. Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding. Acta Crystallogr D Biol Crystallogr. 2013;69:1780-8 pubmed publisher
    ..One of the major actin-remodelling families are the cofilin proteins, made up of cofilin 1, cofilin 2 and actin-depolymerizing factor (ADF), which sever aged ADP-associated actin filaments to reduce ..
  79. Zhang H, Ghai P, Wu H, Wang C, Field J, Zhou G. Mammalian adenylyl cyclase-associated protein 1 (CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion. J Biol Chem. 2013;288:20966-77 pubmed publisher
    ..In vitro actin polymerization assays show that both mammalian and yeast CAP homologues facilitate cofilin-driven actin filament turnover. We generated HeLa cells with stable CAP1 knockdown using RNA interference...
  80. Scott G, McClelland L, Fricke A, Fender A. Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression. J Invest Dermatol. 2009;129:954-63 pubmed publisher
    ..Sema7A activated mitogen-activated protein kinase and inactivated cofilin, an actin-binding protein involved in cell migration...
  81. Anand A, Zhao H, Nagaraja T, Robinson L, Ganju R. N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton. Retrovirology. 2013;10:2 pubmed publisher
    ..that Slit2N specifically attenuated the HIV-1 envelope-induced signaling pathway consisting of Rac1, LIMK and cofilin that regulates actin polymerization. ..
  82. Feldmeyer N, Wabnitz G, Leicht S, Luckner Minden C, Schiller M, Franz T, et al. Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes. Int Immunol. 2012;24:303-13 pubmed publisher
    ..Our proteomic analysis revealed an impaired dephosphorylation of the actin-binding protein cofilin upon T-cell activation in the absence of arginine...
  83. Juno J, Fowke K. Clarifying the role of G protein signaling in HIV infection: new approaches to an old question. AIDS Rev. 2010;12:164-76 pubmed
  84. Okada K, Takano Ohmuro H, Obinata T, Abe H. Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood. Exp Cell Res. 1996;227:116-22 pubmed
    We show that human and porcine polymorphonuclear leukocytes express significant amounts of cofilin, a low-molecular-weight actin regulatory protein, as well as profilin...